WO2018131526A1 - Hydrogen gas inhalator and hydrogen gas inhalation method - Google Patents

Abstract

Provided is a hydrogen gas inhalator and a hydrogen gas inhalation method that allow easy inhalation of a sufficient amount of hydrogen gas into the body. A hydrogen gas inhalator (1) comprises a hydrogen gas-containing material (10), an aluminum pouch (12) (container) housing the hydrogen gas-containing material (10), and a mask (14) (inhalator) enabling inhalation of hydrogen gas generated from the hydrogen gas-containing material (10) inside the aluminum pouch (12). The hydrogen gas-containing material (10) includes: hydrogen gas dissolved in a base material that includes a liquid solvent; and hydrogen gas in the form of gas bubbles contained in the base material. The content ratio of hydrogen gas in the form of gas bubbles in the hydrogen gas-containing material (10) is 0.1 to 70 vol% [v/w].

Description

Hydrogen gas inhaler and hydrogen gas inhalation method

The present invention relates to a hydrogen gas inhaler and a hydrogen gas inhalation method.
This application claims priority based on Japanese Patent Application No. 2017-002991 for which it applied to Japan on January 12, 2017, and uses the content here.

In recent years, hydrogen gas is expected to have various functions such as a function of removing active oxygen (such as hydroxy radicals) (see Non-Patent Document 1) and a function of enhancing biological activity.
Therefore, foods, beverages, cosmetics and the like containing hydrogen gas have attracted attention. It has also been proposed to inhale hydrogen gas and take it into the body.

As the hydrogen gas inhaler, for example, the following are proposed.
(1) A hydrogen gas inhaler comprising a hydrogen gas generator that generates hydrogen gas by electrolysis of water and a cannula for inhaling the hydrogen gas generated by the hydrogen gas generator into the body (Patent Document 1).
(2) A hydrogen gas inhaler comprising an aluminum cheer pack containing hydrogen water and a mask for inhaling hydrogen gas generated from the hydrogen water in the aluminum cheer pack (Patent Document 2).
(3) A hydrogen gas inhaler comprising a container containing a hydrogen generating agent and a cannula or mask for inhaling hydrogen gas generated from the hydrogen generating agent in the container (Patent Document 3).

JP 2005-087257 A JP 2009-039482 A JP 2014-061275 A

The hydrogen gas inhaler (1) has a heavy hydrogen gas generator and requires a power source. Therefore, the hydrogen gas inhaler is difficult to carry and cannot easily inhale hydrogen gas.
The hydrogen gas content of hydrogen water in the hydrogen gas inhaler (2) is at most about 1.6 ppm (2% by volume [v / w]) of the saturation solubility of hydrogen gas in water at 20 ° C. For this reason, the hydrogen gas inhaler of (2) cannot inhale a sufficient amount of hydrogen gas.
In the hydrogen gas inhaler of (3), a gas cleaning device (trap) is provided between the container and the cannula or mask so as not to inhale the powdered hydrogen generator and the impurity gas generated from the hydrogen generator. ) Must be provided. Therefore, the hydrogen gas inhaler (3) is difficult to carry and cannot easily inhale hydrogen gas into the body.

The present invention provides a hydrogen gas inhaler and a hydrogen gas inhalation method capable of easily inhaling a sufficient amount of hydrogen gas into the body.

The present invention has the following aspects.
[1] A hydrogen gas-containing material, a container for containing the hydrogen gas-containing material, and an inhaler for inhaling hydrogen gas generated from the hydrogen gas-containing material in the container; The contained material includes hydrogen gas dissolved in a base material containing a liquid medium and a hydrogen gas in a bubble state contained in the base material; a content rate of the hydrogen gas in the bubble state in the hydrogen gas-containing material is A hydrogen gas inhaler that is 0.1 to 70% by volume [v / w].
[2] The hydrogen gas inhaler according to [1], wherein the base material of the hydrogen gas-containing material further includes a gelling agent or a thickener.
[3] The gelling agent or thickener is selected from the group consisting of gelatin, agar, carrageenan, pectin, guar gum, tamarind gum, glucomannan, carob bean gum, xanthan gum, pullulan, carboxymethylcellulose, alginic acid, alginates, and alginic acid derivatives. The hydrogen gas inhaler according to [2], which is at least one selected.
[4] The hydrogen gas inhaler according to any one of [1] to [3], wherein the container is a glass container or a pouch having an aluminum foil layer.
[5] The hydrogen gas dissolved in the base material containing the liquid medium and the hydrogen gas in the bubble state contained in the base material, and the content rate of the hydrogen gas in the bubble state in the hydrogen gas-containing material is A method for inhaling hydrogen gas, in which hydrogen gas generated from a hydrogen gas-containing material of 0.1 to 70% by volume [v / w] is inhaled into the body.
[6] The hydrogen gas inhalation method according to [5], wherein the base material of the hydrogen gas-containing material further includes a gelling agent or a thickener.
[7] The gelling agent or thickener is selected from the group consisting of gelatin, agar, carrageenan, pectin, guar gum, tamarind gum, glucomannan, carob bean gum, xanthan gum, pullulan, carboxymethylcellulose, alginic acid, alginates, and alginic acid derivatives. [6] The hydrogen gas suction method according to [6], which is at least one selected.
[8] The hydrogen gas inhalation method according to any one of [5] to [7], wherein the hydrogen gas-containing material is orally ingested while inhaling or inhaling hydrogen gas generated from the hydrogen gas-containing material.

According to the hydrogen gas inhaler of the present invention, a sufficient amount of hydrogen gas can be easily inhaled into the body.
According to the hydrogen gas inhalation method of the present invention, a sufficient amount of hydrogen gas can be easily inhaled into the body.

It is a schematic block diagram which shows an example of the hydrogen gas inhaler of this invention.

The following term definitions apply throughout this specification and the claims.
The “gelling agent” refers to a compound capable of forming a network structure capable of holding a liquid medium by physical aggregation by hydrogen bonding or the like or crosslinking by covalent bonding or the like.
“Thickener” refers to a compound capable of imparting viscosity to a liquid medium.
“Hydrogen gas content in the hydrogen gas-containing material (volume% [v / w])” is the volume of hydrogen gas (cm) contained in the predetermined mass (100 g) of the hydrogen gas-containing material in the bubble state. ³ ) The ratio.
“Liquid composition” refers to a composition before gelation or thickening, which includes a gelling agent or thickener and a liquid medium.
The “gel composition” refers to a composition obtained by gelling a liquid composition containing a gelling agent.
“Viscous composition” refers to a composition obtained by thickening a liquid composition containing a thickener.
“Saturated solubility of hydrogen gas in a liquid medium” refers to the saturated solubility of hydrogen gas in a liquid medium (water or the like) under atmospheric pressure. The “dissolution of gas” that defines the saturation solubility is a state in which Henry's law is established and the gas is dissolved in a molecular form according to the pressure.

The content rate of the hydrogen gas in the bubble state in the hydrogen gas-containing material is determined as follows. Under conditions of atmospheric pressure and 25 ° C, 0.5 to 1 g of hydrogen gas-containing material is precisely weighed into a headspace GC analysis sample bottle (capacity: 20 mL) used for GC analysis, and 10 mL of water is added and sealed. To do. After shaking the sample bottle well by hand, mix thoroughly with an ultrasonic cleaner. The sample bottle is heated to 70 ° C. and heating is continued at 70 ° C. until the bubbles disappear from the hydrogen gas containing material. After the bubbles disappear, the gas phase gas in the sample bottle is collected, the hydrogen gas is quantified by gas chromatograph (GC) analysis (TCD detector), and the content of hydrogen gas in the bubble state in the hydrogen gas-containing material (Volume% [v / w%]) is calculated. The saturation solubility of hydrogen gas in water is 1.6 ppm (2% by volume [v / w]) at 20 ° C. and 1.5 ppm (1.8% by volume [v / w]) at 70 ° C., which is almost unchanged. That is, since the amount of dissolved hydrogen gas in the base material (substantially water) of the hydrogen gas-containing material is almost the same before and after the measurement, the hydrogen gas content determined by the above method is the state of bubbles contained in the base material. It can be regarded as the hydrogen gas content.
In the present specification and claims, “to” indicating a numerical range means that numerical values described before and after the numerical value are included as a lower limit value and an upper limit value.

[Hydrogen gas inhaler]
The hydrogen gas inhaler according to the present invention includes a hydrogen gas-containing material, a container for storing the hydrogen gas-containing material, and an inhaler for inhaling hydrogen gas generated from the hydrogen gas-containing material in the container.

(Material containing hydrogen gas)
The hydrogen gas-containing material includes a base material including a liquid medium, hydrogen gas dissolved in the base material, and hydrogen gas in a bubble state contained in the base material.
That is, the hydrogen gas-containing material is, as hydrogen gas, dissolved hydrogen corresponding to a saturated solubility of hydrogen gas in a liquid medium (1.6 ppm (2 vol% [v / w]) at 20 ° C. when the liquid medium is water). The gas and hydrogen gas in a bubble state, which is excess hydrogen gas that could not be dissolved in the liquid medium of the substrate, are included.

<Hydrogen gas>
The hydrogen gas content in the hydrogen gas-containing material is 0.1 to 70% by volume [v / w], preferably 2 to 60% by volume [v / w], and 6 to 50% by volume [v / w]. v / w] is more preferable, and 10 to 45% by volume [v / w] is further preferable. If the hydrogen gas content in the gas state in the hydrogen gas-containing material is equal to or greater than the lower limit of the above range, the total hydrogen gas content in the hydrogen gas-containing material combined with the amount of dissolved hydrogen gas in the substrate is Compared with hydrogen water in a conventional hydrogen gas inhaler that uses only dissolved hydrogen gas, a sufficient amount of hydrogen gas can be supplied. If the content rate of the hydrogen gas in a bubble state in the hydrogen gas-containing material is equal to or less than the upper limit of the above range, the hydrogen gas bubbles can be dispersed in the base material.

The hydrogen gas content in the hydrogen gas-containing material is determined based on the amount of the gelling agent or thickener, the supply of hydrogen gas when the liquid composition contains the hydrogen gas in the bubble state in the production method described later. It can be adjusted by adjusting the amount and the stirring conditions (rotation speed, time, etc.) of the liquid composition.

<Base material>
The base material is a base for dissolving the hydrogen gas in the hydrogen gas-containing material and including the hydrogen gas in a bubble state, and includes a liquid medium as an essential component.
It is preferable that the base material further contains a gelling agent or a thickening agent from the viewpoint that hydrogen gas in a bubble state can be included for a long time and the release rate of the hydrogen gas from the hydrogen gas-containing material can be controlled.
The base material is preferably made of a gel composition or a viscous composition from the viewpoint that a large amount of hydrogen gas in a bubble state can be included for a long time.
The base material may further contain other components other than the liquid medium and the gelling agent or thickener, if necessary.
The substrate can be either solid or liquid.
When the gel composition or viscous composition is liquid, the viscosity of the substrate at 25 ° C. is preferably 1,000 to 300,000 mPa · s, more preferably 5,000 to 200,000 mPa · s, and 10,000. More preferred is 100,000 mPa · s. If the viscosity at 25 ° C. of the base material composed of the gel composition or the viscous composition is equal to or higher than the lower limit value, it is easy to hold the hydrogen gas in the bubble state included in the base material. Moreover, if the viscosity at 25 ° C. of the base material composed of the gel composition or the viscous composition is not more than the above upper limit value, the base material has high fluidity and is easily ingested when taken orally.
The viscosity can be measured using a viscometer (BROOKFIELD, VISCOMETER).
You may adjust a viscosity using the following gelling agent, a thickener, etc.

<Liquid medium>
The liquid medium serves as a medium for dissolving or dispersing the gelling agent, the thickening agent, and other components.
The liquid medium is at least one liquid selected from water capable of dissolving the gelling agent or thickener, a lower alcohol having 1 to 5 carbon atoms, and glycol from the viewpoint of dissolving the gelling agent or thickener. A medium is preferred. Examples of water include purified water. Examples of the lower alcohol include ethyl alcohol and isopropyl alcohol. Examples of the glycol include ethylene glycol, diethylene glycol, propylene glycol, dipropylene glycol, 1,3-butanediol, 1,4-butanediol, and the like.

As the liquid medium, an aqueous medium containing water is preferable. The aqueous medium may further contain a lower alcohol. The proportion of water in the aqueous medium is preferably 50% by mass or more, more preferably 70% by mass or more, and particularly preferably 100% by mass in the aqueous medium (100% by mass).

<Gelling agent, thickener>
Examples of the gelling agent include proteins or polysaccharides derived from natural products, polymers having a hydrogen bonding group, polymers having an aggregating hydrophobic group, polymers having a crosslinkable functional group, polyfunctional monomers, monofunctional Monomers, silicone-based polymers, carboxyvinyl polymers, derivatives thereof, and the like.
Examples of proteins or polysaccharides derived from natural products include gelatin, agar, carrageenan, pectin, glucomannan, pullulan, alginic acid, sodium alginate, potassium alginate, calcium alginate, alginate, propylene glycol alginate, etc. Alginate derivative, aureobasidium culture solution, succinoglycan, ama seed gum, gum arabic, arabinogalactan, welan gum, cassia gum, gati gum, curdlan, caraya gum, carob bean gum, xanthan gum, chitosan, guar gum, guar gum enzyme degradation product, yeast cell wall, Psyllium seed gum, mackerel mugwort seed gum, gellan gum, tamarind seed gum, tara gum, dextran, tragacanth gum, toro Aoi, Microfibrous cellulose, Far celerane, Fukuronori extract, Macrohomopsis gum, Ramzan gum, Levan, Okra extract, Seaweed cellulose, Brown algae extract, Konjac potato extract, Sweet potato cellulose, Soy polysaccharide, Nata de coco, Carboxymethyl cellulose, Agarose Etc.
A gelling agent may be used individually by 1 type, and may use 2 or more types together.

Examples of the thickener include water-soluble polymers. Examples of the water-soluble polymer include organic water-soluble polymers and inorganic water-soluble polymers.
Organic water-soluble polymers include natural polymers (xanthan gum, mannan, pectin, etc.), cellulose semisynthetic polymers (carboxymethylcellulose, sodium carboxymethylcellulose, etc.), synthetic polymers (carboxyvinyl polymer, carboxyvinyl polymer derivatives, Polyvinyl alcohol, polyvinyl alcohol derivatives, polyvinyl pyrrolidone, polyvinyl pyrrolidone derivatives, polyhydroxyethyl methacrylate, polyacrylic acid, polystyrene sulfonic acid, silicone (dimethicone, cyclic dimethicone, methylphenyl polysiloxane, cross-linked dimethylpolysiloxane, methylsiloxane network heavy Coalesced, polyether-modified silicone, acrylic-modified silicone, amedicon, etc.)).
Examples of the inorganic water-soluble polymer include bentonite, which is a kind of clay mineral.
A thickener may be used individually by 1 type and may use 2 or more types together.

As a gelling agent or thickener, gelatin, agar, carrageenan, pectin, glucomannan, pullulan, alginic acid, alginate, alginic acid derivative, aureobasidium broth, succino Glycan, amase gum, arabic gum, arabinogalactan, welan gum, cassia gum, gati gum, curdlan, karaya gum, carob bean gum, xanthan gum, chitosan, guar gum, guar gum enzymatic degradation product, yeast cell wall, psyllium seed gum, mackerel mugwort seed gum, gellan gum, tamarind Seed gum, tara gum, dextran, tragacanth gum, troolloi, microfibrous cellulose, fur celeran, fukuronori extract, macrohomopsis gum, ramzan gum, leva , Okra extract, seaweed cellulose, brown algae extract, konjac potato extract, sweet potato cellulose, soybean polysaccharide, nata de coco, carboxymethyl cellulose, and preferably one or more selected from the group consisting of agarose, gelatin, More preferably, it is one or more selected from the group consisting of agar, carrageenan, pectin, guar gum, tamarind gum, glucomannan, carob bean gum, xanthan gum, pullulan, carboxymethylcellulose, alginic acid, alginates, and alginic acid derivatives. More preferably, it is gelatin.

<Other ingredients>
Examples of other components include food additives, amino acids, amino acid derivatives, nucleic acids, lipids, fats and oils, and surfactants.
Food additives include sweeteners, colorants, preservatives, thickening stabilizers (excluding gelling agents and thickeners), antioxidants, color formers, bleaches, fungicides, yeast foods. , Gum base, cane, bitter, enzyme, brightener, fragrance, acidulant, softener, seasoning, coagulant for tofu, emulsifier, hydrogen ion concentration adjuster (pH adjuster), swelling agent, nutrient enhancer, etc. Food additives.

<Ratio of each component in the substrate>
The proportion of the liquid medium in the substrate is preferably 50 to 99% by mass, more preferably 55 to 97% by mass, and further preferably 65 to 95% by mass in the substrate (100% by mass). If the ratio of the liquid medium is equal to or less than the upper limit of the above range, the liquid composition is sufficiently gelled, and it is easy to hold a large amount of hydrogen gas in a bubble state in the substrate for a long time. If the ratio of the liquid medium is equal to or higher than the lower limit of the above range, the fluidity of the liquid composition is maintained, so that hydrogen gas in a bubble state can be contained in the liquid composition in a large amount for a long time.

When the base material contains a gelling agent, the ratio of the gelling agent is preferably 1 to 50% by weight, more preferably 3 to 45% by weight, and more preferably 5 to 35% by weight in the base material (100% by weight). Further preferred. When the ratio of the gelling agent is at least the lower limit of the above range, the liquid composition is sufficiently gelled, and it is easy to hold a large amount of hydrogen gas in a bubble state in the substrate for a long time. If the ratio of the gelling agent is not more than the upper limit of the above range, the fluidity of the liquid composition is maintained, so that hydrogen gas in a bubble state can be contained in the liquid composition in a large amount for a long time.

When the substrate contains a thickener, the proportion of the thickener is preferably 0.01 to 10% by mass, more preferably 0.02 to 5% by mass in the substrate (100% by mass). If the ratio of the thickener is equal to or more than the lower limit of the above range, the thickening effect is sufficiently exhibited, and it is easy to hold a large amount of hydrogen gas in the base material for a long time. If the ratio of the thickener is less than or equal to the upper limit of the above range, the fluidity of the liquid composition is maintained, so that hydrogen gas in a bubble state can be contained in the liquid composition in a large amount for a long time.

When the substrate contains other components, the proportion of the other components may be appropriately selected within the range of known blending proportions according to the characteristics, functions, etc. required for the hydrogen gas-containing material.

(Method for producing hydrogen gas-containing material)
The hydrogen gas-containing material can be produced, for example, by a method having the following steps (I) to (III) in order.
Step (I): Preparation of a liquid composition containing a gelling agent or thickener and a liquid medium.
Step (II): Inclusion of hydrogen gas in a bubble state in the liquid composition.
Step (III): Production of a hydrogen gas-containing material by gelation or thickening of a liquid composition containing hydrogen gas in a bubble state.

<Process (I)>
Step (I) is a step of preparing a liquid composition containing a gelling agent or thickener and a liquid medium.
The liquid composition can be prepared, for example, by charging a gelling agent or thickener and a liquid medium in a dissolution tank and dissolving the gelling agent or thickener in the liquid medium by stirring. Other components other than the gelling agent or thickener and the liquid medium may be further added to the liquid composition.

Examples of the apparatus used for preparing the liquid composition include a tank or a kettle equipped with a stirrer.
The material of the apparatus is within the range that does not impair the effects of the present invention, taking into consideration the corrosion resistance to gelling agent, thickener, liquid medium, hydrogen gas, etc .; heat resistance at operating temperature; elution into liquid composition, etc. You can choose. Examples of the material for the apparatus include stainless steel, glass lining, fluororesin lining, and plastic. In addition, since flammable hydrogen gas is used, it is also necessary to consider equipment that has taken safety measures to prevent ignition or explosion.

<Process (II)>
Step (II) is a step in which hydrogen gas in a bubble state is included in the liquid composition after step (I).
By supplying hydrogen gas to the liquid composition, a liquid composition containing hydrogen gas in a bubble state is obtained. Other components other than the gelling agent or thickener and the liquid medium may be further added to the liquid composition containing the hydrogen gas in the bubble state.

The viscosity of the liquid composition upon supply of hydrogen gas is preferably 1 to 30,000 mPa · s, more preferably 10 to 20,000 mPa · s, and still more preferably 100 to 10,000 mPa · s.
When the viscosity of the liquid composition is less than the lower limit of the above range, hydrogen gas is likely to be dispersed as bubbles in the liquid composition, but hydrogen gas is likely to float and hardly stay in the liquid composition. When the viscosity of the liquid composition exceeds the upper limit of the above range, it is difficult to disperse hydrogen gas as bubbles in the liquid composition, and it is difficult to uniformly disperse hydrogen gas.
That is, if the viscosity of the liquid composition is equal to or higher than the lower limit value, it is easy to suppress the floating of the hydrogen gas in the dispersion of the hydrogen gas as bubbles in the liquid composition, and it is easy to keep the hydrogen gas in the liquid composition. Moreover, if the viscosity of a liquid composition is below the said upper limit, it will be easy to disperse | distribute hydrogen gas uniformly as a bubble in a liquid composition.
About the temperature of the liquid composition at the time of hydrogen gas supply, what is necessary is just the temperature which can achieve the viscosity range of an above described liquid composition, and should just set it suitably.

The supply amount of the hydrogen gas is an amount such that the total amount of the hydrogen gas dissolved in the liquid composition and the hydrogen gas in the bubble state exceeds the saturation solubility of the hydrogen gas in the liquid medium (water, etc.) The hydrogen gas-containing material thus obtained has a gas content of 0.1 to 70% by volume [v / w].

The charging amount of the gelling agent or thickener and the liquid medium, and the supply amount of hydrogen gas may be appropriately set according to the content of the hydrogen gas in the bubble state in the desired hydrogen gas-containing material. Moreover, what is necessary is just to set suitably about the temperature and the viscosity of a liquid composition according to the kind of gelling agent or thickener, the kind of liquid medium, and the content rate of the gaseous hydrogen gas in the desired hydrogen gas containing material.

As an apparatus used in the step (II), any apparatus and equipment used for a known gas-liquid dispersion operation can be used as long as the apparatus can uniformly disperse hydrogen gas as desired bubbles in the liquid composition. The material of the apparatus is within the range that does not impair the effects of the present invention, taking into consideration the corrosion resistance to gelling agent, thickener, liquid medium, hydrogen gas, etc .; heat resistance at operating temperature; elution into liquid composition, etc. You can choose.

In step (II), hydrogen gas is supplied to the liquid composition while the liquid composition is stirred; or, after the hydrogen gas is supplied to the liquid composition without stirring the liquid composition, the liquid composition is shaken. It is preferable to do.
Examples of the stirring method include a method using a stirrer, a method using a homomixer, a method using a line mixer, and the like.
Examples of the shaking method include a method using a shaker.

<Step (III)>
Step (III) is a step of obtaining a hydrogen gas-containing material by gelling or thickening a liquid composition containing hydrogen gas in a bubble state after step (II).
A liquid composition containing hydrogen gas in a bubble state is placed in a container as necessary and gelled or thickened to obtain a hydrogen gas-containing material.
In order to reduce the volatilization loss of the gaseous hydrogen contained in the liquid composition as much as possible, the liquid composition is preferably gelled or thickened as quickly as possible.

When the liquid composition contains a gelling agent, the substrate made of the gel composition is formed by gelling the liquid composition.
As the gelling method, a method corresponding to the type of the gelling agent may be appropriately selected.
As a gelling method, when the gelling agent has a gelling temperature like proteins or polysaccharides derived from natural products, the liquid composition is cooled by cooling the liquid composition below the gelling temperature of the gelling agent. The method of gelling is mentioned.
As a gelling method, when the gelling agent has a crosslinkable group like a polymer having a crosslinkable functional group, a method of gelling the liquid composition by a crosslinking reaction of the gelling agent can be mentioned.

When a liquid composition contains a thickener, the base material which consists of a thickening composition is formed by thickening a liquid composition.
What is necessary is just to select the method according to the kind of thickener suitably as a thickening method.
As a thickening method, when the thickener has a gelation temperature like a natural polymer, there is a method of thickening the liquid composition by cooling the liquid composition below the gelation temperature of the thickener. Can be mentioned.
As a thickening method, when the thickener is at least one selected from the group consisting of carboxyvinyl polymer and derivatives thereof, polyvinyl alcohol, polyvinylpyrrolidone and derivatives thereof, the thickener is neutralized with a neutralizing agent. The method of thickening a liquid composition by doing is mentioned.
Examples of the neutralizing agent include sodium hydroxide, potassium hydroxide, ammonia, amines (triethanolamine, triethylamine, diisopropanolamine, di (2-ethylhexyl) amine, etc.) and the like. As the neutralizing agent, sodium hydroxide or potassium hydroxide is preferable.
As the gelling agent and the thickener, those derived from natural products are preferable because the hydrogen gas-containing material can be taken orally while inhaling or after inhaling the hydrogen gas generated from the hydrogen gas-containing material.

(container)
The container is preferably a sealed container except for an opening for supplying hydrogen gas in the container to the inhaler from the viewpoint of holding hydrogen gas in the container for a long time.
The container is preferably made of a material that is difficult to permeate hydrogen gas from the viewpoint of suppressing permeation loss of hydrogen gas. Examples of the container made of a material that does not easily transmit hydrogen gas include a glass container, a metal container, a plastic container, and a pouch having an aluminum foil layer (aluminum pouch). As the container, a glass container or an aluminum pouch is preferable, and an aluminum pouch is more preferable because hydrogen gas can be held in the container for a long time and it is easy to carry.

(Inhaler)
Any inhaler may be used as long as it can inhale hydrogen gas into the body, and various inhalers for medical use (tubes, cannulae, masks, combinations thereof, etc.) may be used.

(Specific example of hydrogen gas inhaler)
FIG. 1 is a schematic configuration diagram showing an example of a hydrogen gas inhaler according to the present invention.
The hydrogen gas inhaler 1 includes a hydrogen gas-containing material 10; an aluminum pouch 12 (container) that houses the hydrogen gas-containing material 10; and hydrogen gas generated from the hydrogen gas-containing material 10 in the aluminum pouch 12. A mask 14 (inhaler) for inhaling into the body; and a tube 16 having one end connected to the opening 12 a of the aluminum pouch 12 and the other end connected to the mask 14.

The hydrogen gas inhaler of the present invention contains hydrogen gas dissolved in a base material containing a liquid medium and gas-state hydrogen gas contained in the base material, and the content rate of the gas-state hydrogen gas is 0. A hydrogen gas-containing material of 1 to 70% by volume [v / w]; a container for storing the hydrogen gas-containing material; and an inhaler for inhaling hydrogen gas generated from the hydrogen gas-containing material in the container; As long as it is provided, it is not limited to the illustrated example.

(Mechanism of action)
In the hydrogen gas inhaler of the present invention described above, the hydrogen gas dissolved in the base material containing the liquid medium and the hydrogen gas in the bubble state contained in the base material, and containing the hydrogen gas in the bubble state Since the hydrogen gas-containing material having a rate of 0.1 to 70% by volume [v / w] is provided, the hydrogen gas-containing material has a saturated solubility of hydrogen gas in a liquid medium (water or the like) in the base material of the hydrogen gas-containing material. An equal amount of hydrogen gas is dissolved. That is, the total amount of hydrogen gas dissolved in the substrate and hydrogen gas in the bubble state exceeds the saturation solubility of hydrogen gas in the liquid medium (the amount of hydrogen gas contained in hydrogen water in the conventional hydrogen gas inhaler). Amount. Thus, according to the hydrogen gas inhaler provided with a hydrogen gas-containing material containing a large amount of hydrogen gas, a sufficient amount of hydrogen gas can be inhaled into the body as compared with a conventional hydrogen gas inhaler using hydrogen water. Can fully express in the body various functions (such as a function of removing active oxygen and a function of enhancing biological activity).

In the hydrogen gas inhaler of the present invention described above, since a hydrogen gas-containing material is provided as a hydrogen gas supply source, there is no need to provide a hydrogen gas generator or a gas cleaning device (trap). Therefore, the hydrogen gas inhaler of the present invention is easy to carry and can easily inhale hydrogen gas into the body.

[Hydrogen gas inhalation method]
The hydrogen gas inhalation method of the present invention includes hydrogen gas dissolved in a base material containing a liquid medium and gas-state hydrogen gas contained in the base material, and the inclusion of gas-state hydrogen gas in the hydrogen gas-containing material. This is a method of inhaling hydrogen gas generated from a hydrogen gas-containing material having a rate of 0.1 to 70% by volume [v / w].
As a hydrogen gas containing material, the thing similar to the hydrogen gas containing material in the hydrogen gas inhaler of this invention is mentioned, A preferable form is also the same.

In the hydrogen gas suction method of the present invention, it is preferable to use the hydrogen gas suction device of the present invention.
Hereinafter, a hydrogen gas suction method using the hydrogen gas suction device 1 shown in FIG. 1 will be described.

(Specific example of hydrogen gas inhalation method)
An aluminum pouch 12 (container) containing the hydrogen gas-containing material 10 is prepared. At this time, the opening 12a of the aluminum pouch 12 is sealed by a cap (not shown).
Also, a mask 14 (inhaler) with a tube 16 that has been separately stored is prepared.
The cap is removed from the opening 12a of the aluminum pouch 12, and one end of the tube 16 is immediately connected to the opening 12a of the aluminum pouch 12.
The mask 14 is attached to the face of the user 20 so as to cover the nose and mouth of the user 20, and the user 20 inhales hydrogen gas generated from the hydrogen gas-containing material 10 in the aluminum pouch 12.

When the base material in the hydrogen gas-containing material 10 is made of a gel composition having a gel melting temperature, the hydrogen gas-containing material 10 is heated to a hydrogen gas by heating the hydrogen gas-containing material 10 to a temperature equal to or higher than the gel melting temperature. Can be generated efficiently.
As a method of heating the hydrogen gas-containing material 10 to a temperature equal to or higher than the gel melting temperature, a method in which the aluminum pouch 12 containing the hydrogen gas-containing material 10 is left for a while in an atmosphere equal to or higher than the gel melting temperature; Examples include a method of heating the aluminum pouch 12 by hand; a method of heating the aluminum pouch 12 containing the hydrogen gas-containing material 10 with a heater, a warmer, a container with a heating function, or the like.

The hydrogen gas-containing material 10 may be taken orally while inhaling or inhaling the hydrogen gas generated from the hydrogen gas-containing material 10. For example, the mask 14 is removed from the face of the user 20, the tube 16 is removed from the opening 12 a of the aluminum pouch 12, the opening 12 a of the aluminum pouch 12 is then held in the mouth, and the hydrogen gas-containing material 10 in the aluminum pouch 12. Inhale through the mouth.

Hereinafter, the present invention will be specifically described by way of examples, but the present invention is not limited to these examples.

[Measurement]
The measuring method of the physical property in an Example is shown below.

(Content of hydrogen gas in the bubble state in the hydrogen gas-containing material)
Under conditions of atmospheric pressure and 25 ° C., 0.5 to 1 g of the hydrogen gas-containing material is precisely weighed into a head space GC analysis sample bottle (capacity: 20 mL) used for GC analysis, and 10 mL of water is added and sealed. . The sample bottle was shaken well by hand and then thoroughly mixed with an ultrasonic cleaner. The sample bottle was heated to 70 ° C. and continued to be heated at 70 ° C. until the bubbles disappeared from the hydrogen gas-containing material. After the bubbles disappear, the gas phase gas in the sample bottle is collected, the hydrogen gas is quantified by GC analysis (TCD detector), and the content of hydrogen gas in the bubble state in the hydrogen gas-containing material (volume% [ v / w%]).

(Content of hydrogen gas dissolved in hydrogen water)
The content of dissolved hydrogen gas in hydrogen water is determined by directly collecting hydrogen water from an aluminum pouch containing hydrogen water, quantifying the hydrogen gas in hydrogen water by GC analysis (TCD detector), The content (% by volume [v / w%]) of dissolved hydrogen gas was calculated.

Example 1
7 kg of gelatin and 13 kg of water were placed in a dissolution tank and heated to 40 ° C. to prepare an aqueous gelatin solution (liquid composition). While stirring the gelatin aqueous solution, hydrogen gas was passed through the gelatin aqueous solution to obtain a highly viscous gelatin aqueous solution containing hydrogen gas in a bubble state. An aqueous gelatin solution was filled in an aluminum pouch, and immediately immersed in water at 5 ° C. to be cooled and solidified to obtain an aluminum pouch containing a hydrogen gas-containing material (gel composition). The hydrogen gas-containing material contained hydrogen gas dissolved in the base material and hydrogen gas in a bubble state. The content of hydrogen gas in a bubble state in the hydrogen gas-containing material was 40.0% by volume [v / w].
The hydrogen gas-containing material was taken out from the aluminum pouch and left in an atmosphere at 37 ° C. for 1 hour. The hydrogen gas content in the hydrogen gas-containing material is 3.1 vol% [v / w], and 36.9 vol% [v / w] hydrogen gas may be released in one hour. I understood.

Comparative Example 1
0.5 kg of water was put into the dissolution tank. While stirring the water, hydrogen gas was passed through the water to obtain hydrogen water. Hydrogen water was filled in an aluminum pouch to obtain an aluminum pouch containing hydrogen water. The content rate of the hydrogen gas in hydrogen water was 1.24 volume% [v / w].
Hydrogen water was taken out from the aluminum pouch and left in an atmosphere at 25 ° C. for 1 hour. The hydrogen gas content in the hydrogen water was 0.53 volume% [v / w], and it was found that 0.71 volume% [v / w] hydrogen gas was released in one hour.

The hydrogen gas inhaler of the present invention can inhale a large amount of hydrogen gas into the body and fully develop various functions of the hydrogen gas.

DESCRIPTION OF SYMBOLS 1 Hydrogen gas inhaler 10 Hydrogen gas containing material 12 Aluminum pouch 12a Opening part 14 Mask 16 Tube 20 User

Claims (8)

1. Hydrogen gas-containing material,
   A container containing the hydrogen gas-containing material;
   An inhaler for inhaling hydrogen gas generated from the hydrogen gas-containing material in the container,
   The hydrogen gas-containing material includes a hydrogen gas dissolved in a base material containing a liquid medium and a hydrogen gas in a bubble state contained in the base material,
   A hydrogen gas inhaler, wherein a content rate of the hydrogen gas in a bubble state in the hydrogen gas-containing material is 0.1 to 70% by volume [v / w].
2. The hydrogen gas inhaler according to claim 1, wherein the base material of the hydrogen gas-containing material further includes a gelling agent or a thickener.
3. The gelling agent or thickener is at least selected from the group consisting of gelatin, agar, carrageenan, pectin, guar gum, tamarind gum, glucomannan, carob bean gum, xanthan gum, pullulan, carboxymethylcellulose, alginic acid, alginates, and alginic acid derivatives. The hydrogen gas inhaler according to claim 2, which is one type.
4. The hydrogen gas inhaler according to any one of claims 1 to 3, wherein the container is a glass container or a pouch having an aluminum foil layer.
5. The hydrogen gas dissolved in the base material containing the liquid medium and the hydrogen gas in the bubble state contained in the base material, and the content of the hydrogen gas in the bubble state in the hydrogen gas-containing material is 0.1. A hydrogen gas inhalation method in which hydrogen gas generated from a hydrogen gas-containing material having a volume of 70% by volume [v / w] is inhaled into the body.
6. The hydrogen gas inhalation method according to claim 5, wherein the base material of the hydrogen gas-containing material further includes a gelling agent or a thickener.
7. The gelling agent or thickener is at least selected from the group consisting of gelatin, agar, carrageenan, pectin, guar gum, tamarind gum, glucomannan, carob bean gum, xanthan gum, pullulan, carboxymethylcellulose, alginic acid, alginates, and alginic acid derivatives. The method for inhaling hydrogen gas according to claim 6, which is one type.
8. The method for inhaling hydrogen gas according to any one of claims 5 to 7, wherein the hydrogen gas-containing material is orally ingested while inhaling or inhaling hydrogen gas generated from the hydrogen gas-containing material.

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