JP4836454B2 - 疼痛、特に痛覚過敏治療のための、スポンゴシン（２−メトキシアデノシン）の使用。 - Google Patents
疼痛、特に痛覚過敏治療のための、スポンゴシン（２−メトキシアデノシン）の使用。 Download PDFInfo
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- JP4836454B2 JP4836454B2 JP2004558826A JP2004558826A JP4836454B2 JP 4836454 B2 JP4836454 B2 JP 4836454B2 JP 2004558826 A JP2004558826 A JP 2004558826A JP 2004558826 A JP2004558826 A JP 2004558826A JP 4836454 B2 JP4836454 B2 JP 4836454B2
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- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Engineering & Computer Science (AREA)
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- Immunology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0228723.3 | 2002-12-09 | ||
| GBGB0228723.3A GB0228723D0 (en) | 2002-12-09 | 2002-12-09 | Treatment of pain |
| PCT/GB2003/005379 WO2004052377A1 (en) | 2002-12-09 | 2003-12-09 | Use of spongosine (2-methoxyadenosein) for the treatment of pain, in particular hyperalgesia |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2010270287A Division JP2011132229A (ja) | 2002-12-09 | 2010-12-03 | 疼痛、特に痛覚過敏治療のための、スポンゴシン（２−メトキシアデノシン）の使用。 |
Publications (3)
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| JP2010270287A Withdrawn JP2011132229A (ja) | 2002-12-09 | 2010-12-03 | 疼痛、特に痛覚過敏治療のための、スポンゴシン（２−メトキシアデノシン）の使用。 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010270287A Withdrawn JP2011132229A (ja) | 2002-12-09 | 2010-12-03 | 疼痛、特に痛覚過敏治療のための、スポンゴシン（２−メトキシアデノシン）の使用。 |
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| EP (1) | EP1581235B1 (enExample) |
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| GB (2) | GB0228723D0 (enExample) |
| NO (1) | NO20053042L (enExample) |
| NZ (1) | NZ540353A (enExample) |
| PT (1) | PT1581235E (enExample) |
| SI (1) | SI1581235T1 (enExample) |
| WO (1) | WO2004052377A1 (enExample) |
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| GB0228723D0 (en) | 2002-12-09 | 2003-01-15 | Cambridge Biotechnology Ltd | Treatment of pain |
| GB0305149D0 (en) * | 2003-03-07 | 2003-04-09 | Cambridge Biotechnology Ltd | Compounds for the treatment of pain |
| WO2005084653A2 (en) * | 2004-03-05 | 2005-09-15 | Cambridge Biotechnology Limited | Adenosine receptor agonists |
| AR049384A1 (es) | 2004-05-24 | 2006-07-26 | Glaxo Group Ltd | Derivados de purina |
| US8603779B2 (en) | 2004-12-01 | 2013-12-10 | Syntaxin, Ltd. | Non-cytotoxic protein conjugates |
| US8778634B2 (en) | 2004-12-01 | 2014-07-15 | Syntaxin, Ltd. | Non-cytotoxic protein conjugates |
| US8512984B2 (en) | 2004-12-01 | 2013-08-20 | Syntaxin, Ltd. | Non-cytotoxic protein conjugates |
| US8399400B2 (en) | 2004-12-01 | 2013-03-19 | Syntaxin, Ltd. | Fusion proteins |
| GB0426394D0 (en) * | 2004-12-01 | 2005-01-05 | Health Prot Agency | Fusion proteins |
| GB0514809D0 (en) | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
| GB0610867D0 (en) | 2006-06-01 | 2006-07-12 | Syntaxin Ltd | Treatment of pain |
| EP2081932A2 (en) | 2006-06-27 | 2009-07-29 | BIOVITRUM AB (publ) | 2-o'-methyladenosine derivatives and their use as agonists or antagonists of an adenosine receptor |
| CA2657973A1 (en) | 2006-06-27 | 2008-01-03 | Biovitrum Ab (Publ) | Therapeutic compounds |
| JP2009541438A (ja) * | 2006-06-27 | 2009-11-26 | ビオヴィトルム・アクチボラゲット（プブリクト） | 治療用化合物 |
| US20090181920A1 (en) * | 2008-01-09 | 2009-07-16 | Pgxhealth, Llc | Intrathecal treatment of neuropathic pain with a2ar agonists |
| US8221791B1 (en) | 2008-12-10 | 2012-07-17 | University Of Central Florida Research Foundation, Inc. | Silica-based antibacterial and antifungal nanoformulation |
| CA2766937A1 (en) * | 2009-07-09 | 2011-01-13 | Cbt Development Limited | Combined preparation for use as a medicament |
| WO2011143442A1 (en) * | 2010-05-12 | 2011-11-17 | Trovis Pharmaceuticals, Llc. | A method of treating multiple sclerosis with adenosine receptor agonists |
| EP2631345B1 (en) * | 2012-02-27 | 2019-09-04 | Electrolux Home Products Corporation N.V. | Washing tub unit and washing machine |
| US20140056870A1 (en) | 2012-08-27 | 2014-02-27 | Allergan, Inc. | Fusion proteins |
| CN113999281A (zh) * | 2016-02-04 | 2022-02-01 | 约翰霍普金斯大学 | 平衡型核苷转运蛋白1的抑制剂Rapadocin及其用途 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE792155A (fr) | 1971-12-01 | 1973-05-30 | Takeda Chemical Industries Ltd | Nouveaux derives de l'adenosine et leur procede de production |
| JPS4861498A (enExample) | 1971-12-01 | 1973-08-28 | ||
| JPS5549594B2 (enExample) | 1972-12-08 | 1980-12-12 | ||
| DE2359536C2 (de) * | 1972-12-08 | 1984-08-02 | Takeda Chemical Industries, Ltd., Osaka | 2,6-Diaminonebularinderivate |
| JPS5461194A (en) | 1977-10-21 | 1979-05-17 | Takeda Chem Ind Ltd | Preparation of n22substituted 2*66diaminonebularin |
| JPS5461195A (en) * | 1977-10-21 | 1979-05-17 | Takeda Chem Ind Ltd | N2-substituted phenyl-2,6-diaminonebularin |
| US4705758A (en) * | 1984-06-19 | 1987-11-10 | Warner-Lambert Company | Adenosine receptor assay and kit |
| US5231086A (en) * | 1985-09-24 | 1993-07-27 | Item Development Aktiebolag | Continuous administration adenosine to increase myocardial blood flow |
| US5104859A (en) * | 1985-09-24 | 1992-04-14 | Solimedco Aktiebolag | Continuous administration of adenosine to reduce pulmonary vascular resistance |
| US5310732A (en) * | 1986-02-03 | 1994-05-10 | The Scripps Research Institute | 2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis |
| US5140015A (en) | 1990-02-20 | 1992-08-18 | Whitby Research, Inc. | 2-aralkoxy and 2-alkoxy adenosine derivatives as coronary vasodilators and antihypertensive agents |
| US6180616B1 (en) * | 1990-05-10 | 2001-01-30 | Atsuo F. Fukunaga | Use of purine receptor agonists to alleviate or normalize physiopathologically excited sensory nerve function |
| US6004945A (en) * | 1990-05-10 | 1999-12-21 | Fukunaga; Atsuo F. | Use of adenosine compounds to relieve pain |
| US5679650A (en) * | 1993-11-24 | 1997-10-21 | Fukunaga; Atsuo F. | Pharmaceutical compositions including mixtures of an adenosine compound and a catecholamine |
| US5677290A (en) * | 1990-05-10 | 1997-10-14 | Fukunaga; Atsuo F. | Therapeutic use of adenosine compounds as surgical anesthetics |
| WO1994023723A1 (en) | 1993-04-15 | 1994-10-27 | New York University | Adenosine receptor agonists for the promotion of wound healing |
| US5683989A (en) * | 1993-12-17 | 1997-11-04 | Novo Nordisk A/S | Treatment of ischemias by administration of 2,N6 -substituted adenosines |
| SE9401499D0 (sv) | 1994-05-02 | 1994-05-02 | Item Dev Ab | New method of treatment |
| PL316985A1 (en) | 1994-05-10 | 1997-03-03 | Sandoz Ltd | Derivatives of adenosine |
| US5596094A (en) * | 1994-05-26 | 1997-01-21 | Sandoz Ltd. | Process for preparing 2' -0- alkyl adenosine derivatives |
| US5877180A (en) * | 1994-07-11 | 1999-03-02 | University Of Virginia Patent Foundation | Method for treating inflammatory diseases with A2a adenosine receptor agonists |
| IT1275420B (it) | 1995-06-02 | 1997-08-05 | Schering Plough S P A | Metodo per misurare l'affinita' di legame al recettore a2a dell'adenosina di componenti di interesse farmacologico mediante l'uso del ligando triziato (3h)-sch 58261 |
| AU7449598A (en) | 1997-05-23 | 1998-12-11 | Nippon Shinyaku Co. Ltd. | Medicinal composition for prevention or treatment of hepatopathy |
| US6110902A (en) * | 1997-06-23 | 2000-08-29 | Moehler; Hanns | Method for the inhibition of neuronal activity leading to a focal epileptic seizure by local delivery of adenosine |
| CA2296485A1 (en) | 1997-07-29 | 1999-02-11 | Medco Research, Inc. | N6-substituted-adenosine-5'-uronamides as adenosine receptor modulators |
| US6440455B1 (en) | 1997-09-02 | 2002-08-27 | Children's Medical Center Corporation | Methods for modulating the axonal outgrowth of central nervous system neurons |
| GB9723590D0 (en) * | 1997-11-08 | 1998-01-07 | Glaxo Group Ltd | Chemical compounds |
| EP1044004A1 (en) | 1998-01-08 | 2000-10-18 | The University Of Virginia Patent Foundation | A2a adenosine receptor agonists in combination with a type iv phosphodiesterase inhibitors |
| GB9913932D0 (en) | 1999-06-15 | 1999-08-18 | Pfizer Ltd | Purine derivatives |
| US20030008841A1 (en) * | 2000-08-30 | 2003-01-09 | Rene Devos | Anti-HCV nucleoside derivatives |
| GB0228723D0 (en) | 2002-12-09 | 2003-01-15 | Cambridge Biotechnology Ltd | Treatment of pain |
| WO2004056180A1 (en) | 2002-12-23 | 2004-07-08 | Global Cardiac Solutions Pty Ltd | Organ preconditioning, arrest, protection, preservation and recovery (1) |
| GB0305153D0 (en) | 2003-03-07 | 2003-04-09 | Cambridge Biotechnology Ltd | Identification of therapeutic compounds |
| GB0305150D0 (en) | 2003-03-07 | 2003-04-09 | Cambridge Biotechnology Ltd | Use of therapeutic compounds |
| GB0305149D0 (en) | 2003-03-07 | 2003-04-09 | Cambridge Biotechnology Ltd | Compounds for the treatment of pain |
| WO2005084653A2 (en) | 2004-03-05 | 2005-09-15 | Cambridge Biotechnology Limited | Adenosine receptor agonists |
| US8407664B2 (en) | 2005-12-30 | 2013-03-26 | Sap Ag | Software model business objects |
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2002
- 2002-12-09 GB GBGB0228723.3A patent/GB0228723D0/en not_active Ceased
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- 2003-12-09 CN CNB2003801055073A patent/CN100471503C/zh not_active Expired - Fee Related
- 2003-12-09 KR KR1020057010441A patent/KR101122495B1/ko not_active Expired - Fee Related
- 2003-12-09 NZ NZ540353A patent/NZ540353A/en not_active IP Right Cessation
- 2003-12-09 PT PT03780370T patent/PT1581235E/pt unknown
- 2003-12-09 DK DK03780370T patent/DK1581235T3/da active
- 2003-12-09 AT AT03780370T patent/ATE430572T1/de active
- 2003-12-09 AU AU2003288451A patent/AU2003288451B2/en not_active Ceased
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- 2003-12-09 EP EP03780370A patent/EP1581235B1/en not_active Expired - Lifetime
- 2003-12-09 JP JP2004558826A patent/JP4836454B2/ja not_active Expired - Fee Related
- 2003-12-09 CA CA002507918A patent/CA2507918A1/en not_active Abandoned
- 2003-12-09 US US10/537,564 patent/US8252766B2/en not_active Expired - Fee Related
- 2003-12-09 GB GB0328548A patent/GB2396108B/en not_active Expired - Fee Related
- 2003-12-09 ES ES03780370T patent/ES2326532T3/es not_active Expired - Lifetime
- 2003-12-09 WO PCT/GB2003/005379 patent/WO2004052377A1/en not_active Ceased
- 2003-12-09 SI SI200331633T patent/SI1581235T1/sl unknown
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2005
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2009
- 2009-07-14 CY CY20091100733T patent/CY1109229T1/el unknown
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- 2010-12-03 JP JP2010270287A patent/JP2011132229A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CN101264097A (zh) | 2008-09-17 |
| GB0228723D0 (en) | 2003-01-15 |
| GB2396108A (en) | 2004-06-16 |
| CN100471503C (zh) | 2009-03-25 |
| CA2507918A1 (en) | 2004-06-24 |
| EP1581235A1 (en) | 2005-10-05 |
| SI1581235T1 (sl) | 2009-10-31 |
| AU2003288451A1 (en) | 2004-06-30 |
| DE60327557D1 (de) | 2009-06-18 |
| JP2011132229A (ja) | 2011-07-07 |
| KR20050089815A (ko) | 2005-09-08 |
| GB2396108B (en) | 2005-08-03 |
| US20070010475A1 (en) | 2007-01-11 |
| AU2003288451B2 (en) | 2009-06-04 |
| JP2006514638A (ja) | 2006-05-11 |
| WO2004052377A1 (en) | 2004-06-24 |
| CN101264097B (zh) | 2011-10-05 |
| ATE430572T1 (de) | 2009-05-15 |
| HK1086186A1 (zh) | 2006-09-15 |
| GB0328548D0 (en) | 2004-01-14 |
| CN1723026A (zh) | 2006-01-18 |
| PT1581235E (pt) | 2009-07-07 |
| DK1581235T3 (da) | 2009-08-31 |
| US8252766B2 (en) | 2012-08-28 |
| EP1581235B1 (en) | 2009-05-06 |
| KR101122495B1 (ko) | 2012-03-15 |
| US20110184065A1 (en) | 2011-07-28 |
| ES2326532T3 (es) | 2009-10-14 |
| NZ540353A (en) | 2006-11-30 |
| CY1109229T1 (el) | 2013-09-04 |
| NO20053042L (no) | 2005-06-21 |
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