JP4829558B2 - Insect repellent - Google Patents

Description

The present invention relates to an improvement of an insect repellent containing a drug carrier in which a room temperature volatile drug is supported on a sublimable substance.

Conventionally, as insect repellents for clothing, in addition to sublimable insect repellents such as solid paradichlorobenzene, naphthalene, camphor, etc., liquid room temperature volatile agents such as empentrin are impregnated into a carrier such as paper or plastic in a container. Housed insect repellent is known.
The former sublimable insect repellent has a weak effect on clothing pests such as moths and chickworms, and is problematic in terms of toxicity and environmental pollution. On the other hand, room temperature volatile pyrethroids such as empentrin have a higher insect repellent effect than the former sublimable insect repellents and show a repellent effect in a small amount, but in a form impregnated on a carrier such as paper or plastic, it is effective. There is no change in appearance even at the end point, and the end point of use cannot be clearly recognized.

In view of this, there has been a proposal that a liquid room temperature volatile chemical such as empentrin is supported on a sublimable substance and the disappearance of the sublimable substance is used as an indicator. For example, Japanese Patent Application Laid-Open No. 61-83102 discloses an oil-based insect repellent such as empentrin contained in a molding substrate of a sublimable substance such as paradichlorobenzene or naphthalene and packaged with breathable Japanese paper. Yes. However, in this case, since the drug diffuses through the breathable Japanese paper without restriction, the insect repellent effect does not last long. JP-A-7-285805 discloses a tablet comprising a combination of a room temperature volatile drug and a sublimable substance, part of which is made of a transparent resin film, and the other part is a breathable material such as nonwoven fabric or paper, and Disclosed is an insect pest for clothing pests housed in a packaging container made of a breathable material having a gas permeation suppressing layer formed on a part of its inner surface. This insect repellent is intended so that the end of volatilization of the room temperature volatile chemical and the end of sublimation of the sublimable substance are almost simultaneously, but as shown in the Examples, (4,6-triisopropyl-1,3,5-trioxane) The content of empentrin is high, and even if a non-woven fabric with a large basis weight is used, the risk of oozing out of the drug cannot be avoided. It is also difficult to adjust the sublimation speed.

Japanese Patent Application Laid-Open No. 2004-143146 describes a pest control composition for clothing containing profluthrin or methfluthrin in sunflower. Profluthrin or metofluthrin provides a more effective insecticide than empentrin and provides a useful insecticide, but it is costly and has a lower vapor pressure compared to empentrin and controls volatility when combined with a sublimable substance. However, the current situation is not necessarily efficient.
JP 61-83102 A Japanese Patent Laid-Open No. 7-285805 JP 2004-143146 A

The present invention is an end point of use because the volatilization of the room temperature volatile drug is efficiently controlled and has a high insect-repellent effect, and the volatilization of the room temperature volatile drug and the sublimation of the sublimable substance end almost at the same time. An object is to provide an insect repellent with a clear label.

In order to solve the above problems, the present invention employs the following configuration.
(1) and (a) empenthrin, and (b) Purofurutori down, as the weight ratio of (a) :( b) 10: 1~1: sublimable substance cold volatile pharmaceutical compositions containing in a ratio of 1 An insect repellent comprising 0.5% to 3.0% by weight and containing the drug carrier.
(2) The insect repellent according to (1), wherein the sublimable substance is 2,4,6-triisopropyl-1,3,5-trioxane or adamantane.
(3) An insect repellent in which a drug carrier is housed in a flexible bag, and both surfaces or one side of the flexible bag are internally laminated with a drug permeable film having a thickness of 10 to 30 μm to a weight of 10 to 50 g The insect repellent according to (1) or (2), which is a Japanese paper or non-woven fabric of / m ² , or a long-fiber non-woven fabric having a basis weight of 10 to 50 g / m ² manufactured by a laminate spreading method.

The insect repellent of the present invention has a synergistically high insect repellent effect by efficiently controlling the volatilization of two or three kinds of room temperature volatile chemicals, and also the volatilization and sublimation substances of these room temperature volatile chemicals. Since sublimation ends almost at the same time, the end point display for use is clear, so its practicality is extremely high.

The present invention contains (a) empentrin and (b) profluthrin and / or metfluthrin in a ratio of 10: 1 to 1: 1 as a weight ratio of (a) :( b) as a room temperature volatile chemical. A mixed composition is used. In other words, although profluthrin and metofluthrin exhibit insecticidal and insecticidal effects superior to empentrin, the vapor pressure is lower than that of empentrin, and the insecticide carried on a sublimable carrier is more efficient in volatilizing the chemical and sublimating the sublimable substance. However, by using the mixture composition in the above ratio, volatilization of two or three kinds of drugs and sublimation of the sublimable substance are in an ideal pattern based on the interaction. It has been found that it progresses and has a remarkable synergistic effect in terms of insecticidal and insecticidal effects. Such actions and effects are characteristic in combination with a sublimable carrier, and cannot be obtained with, for example, a paper carrier, and cannot be achieved even if the mixing ratio of both in the sublimable carrier is outside the above range. Was recognized.
Of course, in the acid or alcohol component of the compound, when there are optical isomers and geometric isomers based on asymmetric carbon, these and any mixtures thereof are also included in the present invention.

In the present invention, as long as it does not interfere with the volatilization of the room temperature volatile chemicals, other insecticides, insect repellent components, repellent components, antibacterial components, antifungal components, deodorant components, aromatic components, etc. excellent in volatility Can be blended. For example, antibacterial ingredients such as hinokitiol, tetrahydrolinalool, eugenol, citronellal, allyl isothiocyanate, antifungal ingredients such as isopropylmethylphenol, orthophenylphenol, citronella oil, orange oil, lemon oil, lime oil, yuzu oil, lavender oil, Aroma components such as peppermint oil, eucalyptus oil, jasmine oil, coconut oil, green tea essential oil, limonene, α-pinene, linalool, geraniol, phenylethyl alcohol, amylcinnamic aldehyde, cuminaldehyde, benzyl acetate, “green aroma” and Examples include fragrance ingredients containing Aoba alcohol and Aoba aldehyde.

In the present invention, a sublimable substance is used as a carrier for the room temperature volatile drug. Examples of sublimable substances include 2,4,6-triisopropyl-1,3,5-trioxane [trade name: Sunsaburi (manufactured by Ogawa Fragrance Co., Ltd.)], adamantane, tricyclododecane [trade name: Aisawa D (Idemitsu Oil Co., Ltd.). Chemical Co., Ltd.)], 2-hydroxycamphor (common name: borneol), 2,2-dimethyl-1,3-propanediol (common name: neopentyl glycol), among others, 2,4 , 6-Triisopropyl-1,3,5-trioxane and adamantane are easy to use.

In the present invention, the loading amount of the room temperature volatile drug with respect to the sublimable substance (usually 0.5 to 25 g) is set to 0.5 to 3.0% by weight. If the loading amount is less than 0.5% by weight, the durability of the insect repellent effect may be insufficient. On the other hand, if the loading amount exceeds 3.0% by weight, the drug carrier is accommodated, for example, Japanese paper or non-woven fabric. In order to prevent this, if the weight of the Japanese paper or the nonwoven fabric is excessively increased, it is difficult to control the volatilization of the room temperature volatile chemical and the sublimation of the sublimable substance.
The shape of the sublimable substance is arbitrary, but tablets formed into a plate shape, a rod shape, a disk shape, a donut shape, etc. are common.
As a method for supporting a room temperature volatile chemical, a sublimable substance may be impregnated with a solvent, a surfactant, a dispersant, or the like, if necessary, or a mixture of a chemical and a sublimable substance. It can be cooled after melting, or formed into a tablet using a pressurizer.

A stabilizer, a colorant, an antistatic agent, and the like may be appropriately blended in the drug carrier of the present invention. The addition of color is preferable because it not only increases the commercial value but also makes it possible to clearly see the end point of volatilization of the room temperature volatile chemical.

In addition, a substance other than a sublimable substance can be used as a part of the carrier. Examples thereof include cellulosic carriers such as paper, pulp and viscose, synthetic resin carriers such as ethylene-vinyl acetate resin, polyester and olefin polymer, and inorganic carriers such as calcium silicate. However, these carriers are auxiliary to the volatilization of the drug, and of course the display function is left to the sublimable substance.

The insect repellent of the present invention is used by storing the drug carrier in various bags and containers. For example, a Japanese paper or nonwoven fabric having a basis weight of 10 to 50 g / m ² laminated on the inner surface with a drug permeable film having a thickness of 10 to 30 μm on both sides or one side, or a length of 10 to 50 g / m ² per unit area manufactured by a laminate spreading method Examples thereof include a flexible bag formed of a fiber nonwoven fabric. In the case of one side, a flexible bag in which the other side is formed of a drug-impermeable film is easy to use.
If the drug carrier is housed and used in such a flexible bag, even if the drug carrier shrinks with sublimation of the sublimable substance, at least a part of the drug carrier is a Japanese paper or non-woven fabric in the flexible bag. Because of contact with the inner surface of the material, the room temperature volatile chemical leached from the sublimable substance diffuses into the Japanese paper or the nonwoven fabric, and the volatilization control becomes easy.
The end of volatilization of the room temperature volatile chemical and the end of sublimation of the sublimable substance can be adjusted almost at the same time, and a clear end point display function for use can be achieved.

As the material of the Japanese paper or the nonwoven fabric, any material can be used as long as it can be impregnated and diffused with a room temperature volatile chemical leached from a sublimable substance. However, if the basis weight of the Japanese paper or non-woven fabric is less than 10 g / m ² , the migration and diffusion of the room temperature volatile chemical leached onto the surface of the sublimable substance to the Japanese paper or non-woven fabric is not sufficient, and the volatilization efficiency of the room temperature volatile chemical May decrease as compared with the sublimation efficiency of the sublimable substance.
On the other hand, when the basis weight of Japanese paper or non-woven fabric exceeds 50 g / m ² , flexibility is impaired or opacity increases, making it difficult to visually recognize the disappearance of the sublimation substance from the outside, which is not preferable.

As the material of the drug permeable film laminated on the inner surface of Japanese paper or non-woven fabric, polyolefin such as polyethylene (PE) and polypropylene (PP), or ethylene vinyl acetate (EVA) is suitable, and the wall thickness is 10 to 30 μm. The range of is appropriate.

Moreover, as a raw material for both sides or one side of the flexible bag, a long fiber nonwoven fabric having a basis weight of 10 to 50 g / m ² manufactured by a lamination spreading method can be used.
For example, Teijin's long-fiber nonwoven fabric (trade name: Melfit), which has a multilayer structure of special polyester and special polypropylene, can be used, and has excellent breathability and heat sealability.

When one side of the flexible bag is the Japanese paper, non-woven fabric or long-fiber non-woven fabric, the other side may be formed of a drug-impermeable film. Here, examples of the drug-impermeable film include polyester (PET, PBT, etc.), polyamide, polyacetal, polyacrylonitrile and the like, and the thickness thereof is determined within a range that does not impair flexibility. Further, the film may be colored or printed in order to impart design and character properties.
Then, usually, both surfaces are bonded by means such as heat sealing to produce a flexible bag.

A bag containing a drug carrier (preferably a flexible bag as described above) may be used by being housed in a plastic container having an opening. The shape and size of the plastic container are not limited at all. For example, when the container is used in a clothes chiffon, a closet, a walk-in closet, etc., it is generally provided with a hanging means.

The amount of the insect repellent of the present invention can be determined as appropriate depending on the period of use (6 months, 1 year, etc.), the size of the space to be controlled, etc. What is necessary is just to make the sublimable substance contain about 20-300 mg of room temperature volatile chemicals.

The insect repellent of the present invention thus obtained can be used in large space storage facilities such as chests, costume boxes, closets and walk-in closets. Excellent insecticidal and insecticidal effects against various pests such as chironomid. And since the replacement | exchange time of a chemical | medical agent support body can be easily recognized only by visually observing the disappearance state of a chemical | medical agent support body, it is very useful and practical.

Next, the insect repellent of the present invention will be described in more detail based on specific examples and test examples.

A drug carrier in which 40 mg of empentrin and 10 mg of profluthrin as a room temperature volatile drug are supported on 3.0 g of disc-shaped sunsably (colored in blue) with a thickness of 9 mm (the amount of drug supported on a sublimable substance: 1.7%) ) And stored in a flexible bag (both sides: composed of Japanese paper and a drug-permeable film laminated on the inner surface thereof). These two were designed to be used for one year by putting them in a drawer with a volume of about 50L. The weight of Japanese paper was 20 g / m ² , and the thickness of polyethylene used for the inner surface laminate was 15 μm.

This insect repellent was used by putting it in a drawer with clothes. Over the course of one year, there was no damage from clothing pests and no problems such as bleeding on clothing were observed. In addition, the blue sunsably gradually decreased with the progress of use, and all disappeared after about one year. This insect repellent 1 was very practical because it was easy to use and the end point display was clear.

A drug carrier in which 80 mg of empentrin, which is a room temperature volatile drug, 10 mg of profluthrin and 5 mg of metfurthrin, is carried on 8 g of a disc-shaped adamantane (colored blue) (amount of drug supported on a sublimable substance: 1.2) %) Was prepared, and each was stored in a flexible bag (one side: composed of Japanese paper and a drug-permeable film laminated on the inner surface thereof, the other side: a drug-impermeable polyester film). Each of the two pieces was housed in two plastic containers, and then hung on a clothes chest having a volume of about 800 L, and designed to be used for one year. Moreover, the basis weight of Japanese paper was 25 g / m ² , and the thickness of polyethylene used for the inner surface lamination was 12 μm.

This insect repellent was hung on a clothes chiffon and used for one year. Meanwhile, clothing can be completely protected from clothing pests, and the remaining amount of room temperature volatile chemicals and adamantane are both small and have an excellent end point display function after about one year. Was recognized.

According to Example 1, various drug carriers shown in Table 1 were prepared and then housed in a flexible bag to produce the insect repellent of the present invention. Table 2 shows the results of the volatilization test and the insect repellent test conducted in a 50 L costume box under the condition of 25 ° C.
(1) Volatilization test: The remaining amount of the room-temperature volatile drug and the sublimable substance over time was shown as a relative ratio to the initial value.
(2) Insect repellent test: A woolen cloth was folded in a 23 L transparent costume case. Two samples after the elapse of two months in the volatilization test of (1) were taken out and placed on a woolen cloth in the costume case. After leaving for 2 weeks, a net cage containing 10 moth larvae was placed in the middle layer of the folded woolen cloth, and then the mortality (including knockdown) of the squid larvae was observed after 7 days. Net baskets were installed at two locations.

In the insect repellent of the present invention, the volatilization of empentrin and profluthrin and the sublimation of the sublimation substance proceed almost in parallel by interaction over one year, and as shown in FIG. It became clear that there was a synergistic effect. Moreover, since the volatilization of the room-temperature volatile chemical and the sublimation of the sublimable substance are completed almost at the same time, the excellent end point display function of the present invention was confirmed.
On the other hand, as in Comparative Examples 1 to 4, when the mixing ratio of empentrin and profluthrin carried on the sublimable substance is out of the range of 10: 1 to 1: 1, the volatilization of the room temperature volatile drug is caused by the sublimable substance. It became difficult to control efficiently according to sublimation, and a synergistic insect repellent effect could not be expected.
Further, when the loading amount of the room temperature volatile drug with respect to the sublimable substance exceeded 3.0%, the bleeding into the flexible bag as in Comparative Example 5 was inevitable. Further, as in Comparative Example 6, when two kinds of room temperature volatile chemicals are supported on a pulp mat instead of a sublimable substance, the room temperature volatile chemicals are volatilized even within the range of the mixing ratio. As a result, it was proved that the effects and effects of the examples are based on a combination of a specific room temperature volatile chemical and a sublimable carrier. It was done.

It is drawing which shows the result of the insect repellent test of an insect repellent.

Explanation of symbols

The vertical axis indicates the mortality rate (%), and the horizontal axis indicates the example number (mixing ratio of empentrin and profluthrin). A solid line indicates an actual measurement value, and a broken line indicates a theoretical value.

Claims (3)

(A) and empenthrin, and (b) Purofurutori down, 10 as a weight ratio of (a) :( b): 1~1 : 0 to room temperature volatile pharmaceutical composition sublimable substances contained in a ratio of 1. An insect repellent which is supported by 5 to 3.0% by weight and contains the drug carrier. The insect repellent according to claim 1, wherein the sublimable substance is 2,4,6-triisopropyl-1,3,5-trioxane or adamantane. An insect repellent in which a drug carrier is housed in a flexible bag, and a basis weight of 10 to 50 g / m ² in which both sides or one side of the flexible bag is internally laminated with a drug permeable film having a thickness of 10 to 30 μm. The insect repellent according to claim 1 or 2, wherein the insecticide is a long-fiber nonwoven fabric having a basis weight of 10 to 50 g / m ² , which is a Japanese paper or a nonwoven fabric.