JP4809217B2 - Sheet having elastic characteristics and sliding characteristics, and container for taking in and out solvent using the sheet - Google Patents

Description

  The present invention relates to a sheet used for a liquid inlet / outlet container for a dispensing robot used in a chemical experiment or the like, and a container using the sheet.

  2. Description of the Related Art Conventionally, in a solution dispensing robot used in a chemical experiment or the like, a liquid in a liquid inlet / outlet container (hereinafter referred to as “tank” in the present specification) is used as a pipette tip (hereinafter referred to as the present specification). In this case, it was simply put in and out (dispensed) via the “chip” and used for the subsequent test.

When dispensing relatively low-volatility liquids (water, various salt solutions, etc.) into the tank, it is unlikely that the liquid will be lost even if the tank is open. As shown in FIG. 14, a tank 50 having an open top was used.
On the other hand, when a relatively highly volatile liquid (an organic solvent such as ethanol, methanol, or acetonitol) is dispensed into the tank 50, the solvent volatilizes from the opening, and the solvent may be reduced. Normally, the opening is closed with a lid 52, and when the liquid in the tank 50 is dispensed with the chip 51, the lid 52 is removed and used.

  However, when the tank shown in FIG. 14 is used, this type of lid 52 cannot seal the tank 50 and cannot prevent the organic solvent from being reduced due to volatilization. When the organic solvent in the tank 50 is reduced, the solvent injected first is reduced, which causes a problem that the result of quantitative analysis cannot be accurately obtained. In recent years, trace analysis technology has been developed, and it is considered that the influence of the volatilization of the solvent in the container on the analysis result is particularly large. In addition, it is necessary to perform the attaching and detaching operations of the lid 52 for each dispensing operation. As a result, there is a problem that the working efficiency of dispensing and the subsequent test is lowered.

  Furthermore, since pipette tips 51 themselves are made of resin having higher chemical resistance than metal ones, so-called septums have been considered in consideration of the hermeticity of tanks. However, since only a metal tip (needle) can be penetrated, it cannot withstand a plurality of insertions and removals and cannot be employed.

  Therefore, when using a resin chip, it is considered that the opening of the tank 50 is covered with a sheet 53 having a single slit 54 as shown in FIG. However, if the number of insertions / disconnections of the chip 51 is large and a plurality of chips 51 are provided, wear around the slit 54 becomes significant, the slit 54 itself is not opened and sealed, and volatilization of the liquid cannot be prevented. It was not possible to prevent the liquid in the tank from being lost.

As the above improvement measure, as shown in FIG. 16, a tank 50 whose opening is covered with a sheet 53 provided with radial slits 55 has been proposed.
The radial slits 55 provided in the sheet 53 are provided in correspondence with the chips 51. If the chips 51 are eight, the sheet 53 has eight radials corresponding thereto. The slit 55 is provided.

  However, if the sheet 53 is also frequently inserted and removed, the radial pieces 55a, 55b,... Of the slits 55 are deformed due to frictional resistance with the chip 51, and the sealing performance of the tank 50 is lowered. There wasn't.

  It is an object of the present invention to facilitate the insertion and removal of chips when used to seal the opening of a container for dispensing liquid used for dispensing robots used in chemical experiments and the like. The object is to obtain a sheet capable of preventing the natural volatilization of the liquid in the container even if the frequency is high.

As a result of intensive studies to achieve the above object, the present inventors have obtained the knowledge that a sheet formed by laminating a specific sheet can achieve the above object, thereby completing the present invention.
The present invention has been made based on the above findings, and provides a sheet obtained by laminating a sheet having elastic characteristics and a sheet having slipping characteristics.
Further, the present invention is a container for taking in and out the liquid stored inside through an opening, and the opening is sealed with a sheet formed by laminating a sheet having elastic characteristics and a sheet having sliding characteristics. A container for liquid in / out is provided.

  In other words, when inserting and removing the chip, the sliding characteristic works and the resistance is low. On the other hand, the resilience is demonstrated by the elastic characteristic and the original state is restored, so that the container can be sealed regardless of the number of times the chip is inserted and removed. Is done. After aspirating the liquid in the tank, when the pipette tip is pulled up, the slit portion of the sheet wipes off the outer surface of the tip. Since it leaves, there is an effect that the specified amount can be measured more accurately.

Hereinafter, the sheet | seat of this invention is demonstrated.
The sheet of the present invention is formed by laminating a sheet having elastic characteristics and a sheet having slipping characteristics.
The sheet | seat of this invention is used in order to seal the opening of the container for liquid in / out for the dispensing robot used by a chemical | medical experiment etc. Specifically, it is used to seal the opening of a container through which liquid stored inside is taken in and out through the opening. That is, the present invention can be used as an opening-sealing sheet for liquid containers.
Hereinafter, the case where the sheet | seat of this invention is used in order to seal the opening of the said container is demonstrated, referring drawings.

  FIG. 1 is an exploded perspective view showing a state in which a sheet 20 is attached to a liquid container 10 (hereinafter referred to as “tank” in this specification), and FIG. It is a partially broken figure which shows the operation | work which takes in and out the liquid 12 through the chip | tip 51 (dispensing).

As shown in the figure, the tank 10 is covered with a sheet 20 so as to close the opening 11 thereof.
Usually, a base plate 30 for supporting the sheet 20 is provided in the opening 11, and the sheet 20 is disposed on the base plate 30.
On the other hand, the clamp plate 40 is placed on the upper surface of the sheet 20.
As the material of the tank 10, conventionally, the material of the container used in the solution dispensing robot used in the chemical experiment or the like is used without particular limitation. However, since the organic solvent may be used, the organic solvent Those which are resistant to Examples of such a material include polyethylene, polypropylene, and polycarbonate.

In addition, as the material of the base plate 30, conventionally, the material of the base plate used in a solution dispensing robot used in a chemical experiment or the like is used without particular limitation,
Examples of such a material include polyethylene, polypropylene, polycarbonate, polytetrafluoroethylene, stainless steel, aluminum, and polyimide.
Further, the clamp plate 40 is made of a metal plate material, and the sheet 20 is sandwiched between the clamp plate 40 and the base plate 30 by its own weight, thereby restricting bending and movement.

The base plate 30 has a hole 30a, and the clamp plate 40 has a hole 40a.
Each of the holes 30a and 40a is disposed at the same position in the vertical direction as a later-described slit.

For example, the sheet 20 is formed by laminating an A sheet 21 and a B sheet 22.
As the A sheet 21, a sheet material having a low resistance when the chip 51 is inserted and withdrawn, that is, a sheet having a sliding characteristic is used. As a specific example of the sheet having slip characteristics, a sheet having a dynamic friction coefficient and a static friction coefficient of 0.2 or less is preferable although it depends on the material and shape of the chip and the slit shape. In addition, a dynamic friction coefficient and a static friction coefficient can be measured according to ASTM-01894-63.
Specific examples of the sheet material having a sliding property include polypropylene (PP), polyethylene (PE), polymethylpentene (PMP) having a thickness of 0.5 mm or less, or polytetrafluoroethylene (PMP) having a thickness of 1 mm or less ( PTFE). In particular, PTFE has a friction coefficient of 0.1 to 0.05 or less and is used as an ideal sheet material.

Further, as the B sheet 22, an elastic sheet material that restores the slit piece (see FIG. 3) to the original position even when the chip 51 is repeatedly inserted and removed, that is, a sheet having elastic characteristics is used.
As a sheet material having an elastic property, a sheet having a hardness Hs of 30 ° to 90 ° and a rebound resilience of 20% to 50% is preferable, corresponding to the material / shape of the chip, the slit shape, and the sheet thickness. Selected. Specifically, a silicone rubber material having a thickness of 0.5 to 1.0 mm is used. The hardness can be measured according to JIS K 6253, and the impact resilience can be measured according to JIS K 6253. ,

Examples of the sheet material that replaces the silicone rubber material include fluororubber, perfluoro (perfluoroelastomer) rubber, nitrile rubber, chloroprene rubber, ethylene propylene rubber, and polyimide resin. Which sheet material is used can be selected in consideration of heat resistance, chemical resistance, oil resistance, etc. in relation to the liquid stored in the tank. When used in a facility that requires light shielding (RI or the like), the sheet material can be shielded by using a material that does not allow light to pass through, such as black silicone rubber or fluorine rubber.
In order to further improve the sealing performance, a support tool that is not completely cut or perforated from above the B sheet may be used. Examples of the material for the support at that time include polyimide and aluminum.

  In such A sheet 21 and B sheet 22, the laminated state may be a state in which both sheets are simply overlapped, or may be a state in which the sheets are adhered with an adhesive or the like. In particular, when both sheets are integrated, at least one of them may be applied by a coating technique.

  The sheet is preferably provided with slits (cuts) in each of the sheets, the A sheet 21 and the B sheet 22, and the slit shape is radial (FIGS. 3A and 3B). )) And a cross shape (see FIG. 4 (a)), and those formed to extend in one direction (see FIG. 4 (b)). The slits formed in both sheets are preferably arranged in a state where they are overlapped between the upper and lower sides. That is, it is preferable that the slit provided in the sheet having the elastic characteristics and the slit provided in the sheet having the slip characteristics are provided so as to substantially overlap.

  On the other hand, the slit may be in a state that is not cut in advance and is not completely cut. That is, the cut line may not penetrate in the thickness direction of the sheet, and the cut line may stop in the middle of the sheet thickness direction. FIG. 5 is a cross-sectional view of the sheet of the present invention, showing various modes of slit slitting. As shown in FIG. 5 (a), it may be a state with almost no cut width, or it may be cut with a certain width as shown in FIG. 5 (b). As shown in d), various cuts such as a V-groove cut may be used.

By using such a cut sheet, the container has a sealing property because the cut does not penetrate during the reaction process, that is, when the operation of taking out the liquid stored in the tank by the chip is not performed. In addition, the tip of the tip can be easily inserted into the container through this notch in the operation of taking out the liquid after the reaction with the tip. That is, when the chip is inserted into the notch, the notch is formed halfway in the thickness direction of the sheet, so that the chip is inserted and the notch is easily broken so that the chip can penetrate the sheet.
In addition, after aspirating the liquid stored in the tank, when the pipette tip is pulled up, the slit part of the sheet wipes off the outer surface of the tip. It has the effect of removing the excess solution that has adhered. With this effect, the specified amount can be measured more accurately.

  A suitable example for the use of such a container is an experimental technique essential for manipulating genes in the field of molecular biology, namely PCR (polymerase chain reaction). This PCR is a method of amplifying a specific target DNA sequence from a very small amount in a container using a heat-resistant DNA polymerase.

  Usually, in this type of PCR, the liquid is repeatedly treated in a container about 25 times in a temperature cycle of, for example, about 55 ° C. to 94 ° C. By this treatment, the inside of the container becomes high temperature and pressure. Therefore, the container is tightly sealed with a lid or the like until the end of the reaction process so that the liquid does not volatilize.

However, in this way, it is not easy to take out the liquid from a container that is firmly clamped by a lid or the like. That is, it is necessary to remove a tightly-tightened lid or the like when taking it out, which makes the experiment work cumbersome.
Therefore, in order to eliminate this bothersomeness, if the container is sealed using the above-mentioned “sheet that is not completely cut”, the sealed state during the reaction treatment and the cut-out at the time of solvent removal are removed. Ease of inserting the chip into the non-existing part can be secured.

Next, a dispensing operation using the sheet 20 having the radial slits will be described with reference to FIGS.
The dispensing operation will be described with reference to one chip 51. First, the tip of the chip 51 is inserted into the radial slit 21a of the A sheet 21 from the hole 40a of the clamp plate 40. At this time, the cut pieces 21b, 21c,... Of the radial slit 21a shown in FIG.

Next, similarly, it enters the slit 22a (see FIG. 3B) of the B sheet 22, and after a predetermined amount of the liquid 12 in the tank 10 is injected by the chip 51, the chip 51 is pulled out.
At the time of drawing, the B sheet 22 is made of a highly elastic sheet, so that the cut pieces 21b, 21c,... Of the slit 22a are also rich in elastic force and easily return to the original position. That is, the slits are closed by the cut pieces 21b, 21c. On the other hand, the A sheet 21 is not worn with no resistance to the chip 51 that is pulled out due to its sliding characteristics.

  Thus, even if the chip 51 is repeatedly inserted and removed, the ease of insertion and extraction and the sealing property in the tank can be ensured without loss.

  The above description is naturally one, and even when a plurality of chips 51 (eight in the illustrated example, 24, 96, 384, 1536, etc.) are used, the radial slit corresponding to any chip 51 is used. Since 21a and 22a each ensure the ease of insertion and extraction and airtightness, the liquid stored in the tank 10 can be prevented from volatilizing naturally.

  The radial slits 21a and 22a provided in the A sheet 21 and the B sheet 22 are cut radially from the centers 21o and 22o, respectively. The cuts are extended depending on the sheet thickness, for example, adjacent radials. It may be combined with the slit, and the slit spreads over the entire sheet, causing operability to deteriorate. Therefore, the ends of the slits are holed or lined as necessary. 3 (a) and 3 (b) show radial slits that are secured by holes, and FIG. 3 (c) shows radial slits that are secured by lines.

  Further, the positional relationship between the slits 21a and 22a is such that the centers 21o and 22o are located at the same position in the vertical direction and the notches (slits) are substantially overlapped in order to smoothly insert and remove the chip 51. Further, as shown in FIGS. 3A and 3B, in order to maintain hermeticity, for example, the slits 21a and 22a may be arranged so as not to overlap each other. That is, the cuts shown in FIGS. 3A and 3B are provided at an angle of about 45 °. Arranging the cuts so as not to overlap each other means that the slits 21a and the slits 22a are displaced by about 22.5 °. As described above, the slits 21a and 22a are arranged so as to be shifted by about 22.5 ° C., thereby further improving the sealing performance of the tank.

The shape of the slit is not particularly limited as long as the chip can be smoothly inserted and removed. In addition to the radial shape shown in FIG. 3, for example, as shown in FIG. You may make it a shape. For example, FIG. 6 (a) is a bowl shape, (b) is a spiral shape, (c) is a V shape, (d) is an arrow shape, (e) is an H shape, and (f) is a shape of (e). A shape with a single cut, (g) is U-shaped, and (h) is an S-shaped cut. The shape of the cut formed in the sheet of the present invention is not limited to that described above, and may be any shape as long as the chip can be smoothly inserted and extracted.
The sheet of the present invention is formed by laminating a sheet having elastic characteristics and a sheet having slipping characteristics, and each of the two sheets may have the same shape or a combination of different shapes. May be. Moreover, when two sheets are of the same shape, the respective cuts may overlap each other, and the respective cuts may be shifted.

  In the above description, the liquid inlet / outlet container (tank) 10 has one opening 11, that is, the so-called one liquid storage part. However, the liquid inlet / outlet container of the present invention is the above-described one. It is not limited.

  That is, it is meaningful even in the case where the storage part is formed corresponding to the opening part 11 by being partitioned by the plurality of opening parts 11 like the tank 10 shown in FIG. Such a tank can improve the efficiency and speed of the dispensing work by being used in a robot for dispensing different solutions.

  In the sheet 20 attached to the tank 10, the same slits (21 a, 22 a) are provided corresponding to the openings 11 as shown in FIG. In the dispensing operation, an operation is performed in which a chip is inserted into each slit, a liquid is injected into the storage portion, and then extracted.

  Furthermore, the liquid in / out container shown in FIG. 7B is composed of a plurality of tubular tanks 10. In this container, the tank 10 has a plurality of openings 11 and is an independent storage portion. A plurality of tubular tanks 10 are arranged (accumulated) vertically and horizontally as required (see FIG. 7). In the liquid container shown in FIG. 7 (b), the tube has 8 rows and 12 rows and has 96 tubes.

  Although not shown in the drawing, the sheet-like tank 10 has a sheet slit corresponding to the opening 11 corresponding thereto. The minimum number of tube-like tanks 10 may be one, and when a plurality of dispensing operations are performed, a plurality of tanks 10 corresponding to the number can be accumulated. In any case, it greatly contributes to high efficiency and high speed of the dispensing work.

  As described above, the clamp plate 40 is made of a metallic plate material, and the sheet 20 is sandwiched between the clamp plate 40 and the base plate 30 by its own weight to restrict bending and movement, but a plurality of chips 51 (FIG. 7 ( In the example shown in b), the number is 96, but the friction between the sheet 20 and the tip 51 is determined at the time of simultaneous dispensing (for example, including tubes having 8, 16, 24, 48, 384, 1536, etc.). As a result, the base plate 30, the sheet 20, and the clamp plate 40 may float upward. Another embodiment of the clamp plate 40 for solving such a problem will be described with reference to the drawings.

FIG. 8 is a diagram for explaining another embodiment of the clamp plate 40. In order to prevent the base plate 30, the sheet 20, and the clamp plate 40 from floating upward at the time of dispensing, the clamp plate 40 is illustrated. A support plate 80 to which an elastic member 82 such as a spring can be attached is attached to the side surface. The tank 10 can be moved, for example, when an experiment is performed while changing the temperature by reaction, and this movement is performed by a solution dispensing robot. When the solution dispensing robot moves the tank, it comes into contact with the tank. At this time, the elastic member 82 attached to the clamp plate 40 comes into contact with another member of the solution dispensing robot (not shown), When the chip is pulled out, the member of the solution dispensing robot is pushed back by the action of the elastic member 82, so that the solution dispensing robot is easily separated from the clamp plate 40, and the clamp plate 40, the base plate 30, the sheet 20 has the effect of preventing the lifting of the tank 20 and the weight of the tank 10 increases due to the weight of the elastic member itself. Therefore, the adhesion between the sheet 20 and the tank 10 when the chip 51 is pulled out can be improved. The sealing performance can be improved.
FIG. 9 shows another embodiment of the clamp plate 40. In FIG. 9, an elastic member 82 is attached to the clamp plate 40 itself. Also in this embodiment, the same effect as FIG. 8 can be expected.
FIG. 10 shows another embodiment of the clamp plate 40. In this case, the clamp plate 40 is fixed to the tank 10 with screws 94 that are fixing members. Since the clamp plate 40 is fixed to the tank 10, it is possible to prevent the clamp plate 40, the base plate 30 and the sheet 20 from being lifted.

In the liquid in / out container having a plurality of tubular tanks 10 shown in FIG. 7B, as the number of tubes increases, the edges of the opening portions 11 of the individual tubes of the sheet 20 and the tank 10 The sealing performance of the tank may be reduced, and the solvent in the tank may volatilize. The edge part of the opening part 11 of each tube is formed so that it may rise rather than the periphery. That is, since a protrusion may be formed, a gap is formed between the base plate 30 and the opening 11 of the tube when the base plate 30, the sheet 20, and the clamp plate 40 are placed thereon. From here, the solvent in the tank volatilizes. FIG. 11A is a perspective view of a base plate 30 according to another embodiment, and FIG. 11B is an enlarged cross-sectional view when the base plate 30 is placed on the tank 10. A partially enlarged perspective view is shown in a circle in the figure. As shown in FIG. 11, a groove 92 is formed in a portion of the base plate 30 that comes into contact with the liquid inlet / outlet container, and this groove 92 overlaps the protrusion formed on the edge of the opening 11 of the container described above. , No gap is formed, and the solvent in the tank can be prevented from volatilizing. As shown in FIG. 11B, when the protrusion 94 is formed at the edge of the opening of the tank 10, it contacts the opening 11 of the tank 10 of the base plate 30 so as to be substantially the same as the shape of the protrusion. By forming the groove 92 in the portion, the gap between the base plate 30 and the tank 10 can be closed, and the liquid can be prevented from volatilizing.

Hereinafter, the present invention will be described more specifically with reference to examples. However, the present invention is not limited thereto.
Example 1
Using the container shown in FIG. 1, a test was conducted on the volatility of the tank in the container. Into a container, 20 ml of acetonitrile is placed, a base plate is placed on the tank, a sheet of the present invention is placed thereon, a polytetrafluoroethylene lid is further placed thereon, and the container is placed at 4 ° C. The sample is left in a refrigerator, and after 1 hour, 3 hours, 8 hours, and 22 hours, the weight of acetonitrile remaining in the tank is measured, and the volume of acetonitrile that decreases within a certain time is determined. Went.
The sheet used was formed with a radial cut (shaped as shown in FIG. 3C), and had a shape such that the cuts of the two sheets overlapped. In addition, as a sheet | seat which has the thickness made from silicone rubber as a sheet | seat which has an elastic characteristic, the sheet | seat made from polytetrafluoroethylene used the sheet | seat which has a thickness of 0.1 mm as a sheet | seat which has a sliding characteristic. (Hereafter referred to as overlap type).

Also, using sheets made of the same material, the cuts of the two sheets do not overlap, that is, the two sheets are overlapped by shifting the cuts of both about 22.5 °, and the same as above Were tested (hereinafter referred to as cross-type).
Further, the same test was performed without making a cut on a sheet made of the same material (hereinafter referred to as a sealed type). Further, 20 ml of acetonitrile was put in a container without placing the sheet on top, and left as it was in a refrigerator at 4 ° C. (hereinafter referred to as “no lid”).
The results are shown in Table 1. The numbers in Table 1 are the volume (ml) of acetonitrile remaining in the tank. The results are shown in FIG. FIG. 12 is a graph showing the results of a volatility test when a sheet is placed on a container. In the graph, the horizontal axis represents time, and the vertical axis represents the residual amount in the container.

  As shown in Table 1 and FIG. 12, when left at 4 ° C. without a lid, it was found that more than half of acetonitrile volatilized in 22 hours. Moreover, 19.5 ml of acetonitrile remained even after 22 hours had passed in the case where the sheet was placed and sealed. In the sheet on which the sheet of the present invention was placed, 18.2 ml of acetonitrile remained in the overlap type, and 19.1 ml of acetonitrile remained in the cross type. From this result, it can be seen that the sheet of the present invention has an effect of suppressing volatilization of the solvent in the tank.

Example 2
Next, the durability of the sheet with respect to chip insertion / extraction was examined. The test was performed using the container used in Example 1. The test was performed in the crossing type in Example 1. 10 ml of acetonitrile was put in the tank, the chip was inserted into the sheet cut, 0.2 ml of acetonitrile in the tank was sucked, and then this acetonitrile was returned to the tank. Next, the chip was removed from the cut, and the chip was inserted into the sheet cut again. This operation was repeated 100 times at a temperature of 20 ° C. This operation was performed for 200 seconds. This operation was performed three times. The amount of acetonitrile remaining in the tank was determined by measuring the weight of acetonitrile remaining in the tank. The results are shown in Table 2.

  When the cross-type sheet was examined with the naked eye whether or not the sheet was deformed, some deformation of the sheet having slipping characteristics was recognized, but no deformation was recognized in the sheet having elastic characteristics, and the present invention. It was found that the test sheet was smoothly deformed with little deformation even when the sheet was inserted and removed about 100 times. As for the volatilization of the liquid, a little volatilization was observed in only 200 seconds without the lid, but almost no volatilization of acetonitrile was observed when the sheet of the present invention was used. That is, it was confirmed that the airtightness was maintained even during repeated insertion and removal of the chip.

Example 3
Using the container shown in FIG. 7, the volatility of water in the tank in the container was tested. Place 300 μl of water in the container, place the base plate made of polytetrafluoroethylene on the tank, place the sheet of the present invention on it, and place a stainless steel lid on it. Was placed in a constant temperature bath at 37 ° C. and stirred at 400 cm ⁻¹ rpm. After 0.5 hours, 1 hour, 2 hours, 4 hours, 6 hours and 22 hours, weigh the water remaining in the tank, determine the volume of water that decreases within a certain time, and test the volatility Went.
The sheet used was formed with a radial cut (shaped as shown in FIG. 3C), and had a shape such that the cuts of the two sheets overlapped. In addition, as a sheet | seat which has the thickness made from silicone rubber as a sheet | seat which has an elastic characteristic, the sheet | seat made from polytetrafluoroethylene used the sheet | seat which has a thickness of 0.1 mm as a sheet | seat which has a sliding characteristic. (Hereafter referred to as overlap type). In addition, the same operation was performed without creating a cut in a sheet made of the same material (hereinafter referred to as a sealed type). Further, the sheet was left as it was in a constant temperature bath at 37 ° C. without being placed on top (hereinafter referred to as “no lid”).

  The results are shown in Table 3. The numbers in Table 3 are numbers representing the percentage of the amount of water remaining in the tank as a percentage of the remaining volume with respect to the initially charged volume. The results are shown in FIG. FIG. 13 is a graph showing the results of a volatility test when a sheet is placed on a container. In the graph, the horizontal axis represents time, and the vertical axis represents the residual amount in the container.

  As shown in Table 3 and FIG. 13, when it was shaken in an environment of 37 ° C. without a lid, it was found that about half of the water volatilized in 22 hours. In addition, in the case where the sheet was placed and sealed, most of the water remained even after 22 hours. The sheet on which the sheet of the present invention was placed had 93% water remaining. Therefore, when the sheet | seat of this invention was mounted on the container and mounted so that opening might be sealed, it turned out that the volatilization effect of the outstanding solvent is shown.

It is a disassembled perspective view explaining the container for liquid in / out. It is a partially broken figure explaining dispensing work. It is explanatory drawing of a radial slit. It is explanatory drawing which shows the other example of a slit. It is sectional drawing of the sheet | seat of this invention. It is explanatory drawing which shows the other example of a slit. It is explanatory drawing which shows the other example of the container for liquid in / out. It is explanatory drawing of the base board which attached the elastic member for prevention of lifting. It is explanatory drawing of the base board which attached the elastic member for prevention of lifting. It is explanatory drawing of the base board which attached the screw | thread for prevention of lifting. It is explanatory drawing of the base plate which formed the groove | channel in the contact surface. It is a graph which shows the result of a volatility test. It is a graph which shows the result of a volatility test. It is explanatory drawing of the conventional open type tank. It is explanatory drawing of the conventional sealed tank. It is explanatory drawing of another conventional sealed tank.

Explanation of symbols

10 Liquid In / Out Container 20 Sheet 21 A Sheet 22 B Sheet
21a Radial slit 22a Radial slit 21o Center 22o Center 30 Base plate 40 Clamp plate 51 Chip 80 Support plate 82 Elastic member 84 Screw 92 Groove 94 Protrusion

Claims (6)

A sheet having elastic properties made of silicone rubber, fluoro rubber, perfluoro (perfluoroelastomer) rubber, nitrile rubber, chloroprene rubber, ethylene propylene rubber, or polyimide resin, and made of polypropylene, polyethylene, polymethylpentene, or polytetrafluoroethylene A sheet formed by laminating sheets having slipping characteristics ,
A radial slit is provided in each of the sheet having the elastic property and the sheet having the sliding property, and the center of the radial slit of the sheet having the elastic property and the center of the radial slit of the sheet having the sliding property are the same in the vertical direction. The sheet is arranged so that the cuts of the radial slits of the sheet having the elastic characteristics do not overlap the cuts of the radial slits of the sheet having the sliding characteristics . The sheet having the elastic property is made of a silicone rubber having a thickness of 0.5 to 1.0 mm, and the sheet having the sliding property is a polypropylene, polyethylene, polymethylpentene or polytetrafluoro having a thickness of 0.1 to 0.5 mm. The sheet according to claim 1, comprising ethylene. The sheet according to claim 1 or 2, wherein a notch of the radial slit of the sheet having the elastic characteristic and a notch of the sheet radial slit having the slip characteristic are shifted by 22.5 °.   The sheet | seat of any one of Claims 1-3 whose sheet | seat which has the said elastic characteristic is a sheet | seat whose dynamic friction coefficient and static friction coefficient are 0.2 or less.   The sheet according to any one of claims 1 to 4, wherein the sheet having the slip property is a sheet having a hardness Hs of 30 ° to 90 ° and a rebound resilience of 20% to 50%. A container for taking in and out the liquid stored therein through the opening,
A sheet having elastic properties made of silicone rubber, fluoro rubber, perfluoro (perfluoroelastomer) rubber, nitrile rubber, chloroprene rubber, ethylene propylene rubber, or polyimide resin, and made of polypropylene, polyethylene, polymethylpentene, or polytetrafluoroethylene A sheet formed by laminating sheets having slipping characteristics ,
A radial slit is provided in each of the sheet having the elastic property and the sheet having the sliding property, and the center of the radial slit of the sheet having the elastic property and the center of the radial slit of the sheet having the sliding property are the same in the vertical direction. The liquid is characterized in that it is sealed with a sheet that is arranged so that the cuts of the radial slits of the sheet having the elastic characteristics and the cuts of the sheet radial slits having the sliding characteristic do not overlap. Container for entry and exit.

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