JP4773157B2 - サンプルマニピュレータ - Google Patents
サンプルマニピュレータ Download PDFInfo
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- JP4773157B2 JP4773157B2 JP2005235873A JP2005235873A JP4773157B2 JP 4773157 B2 JP4773157 B2 JP 4773157B2 JP 2005235873 A JP2005235873 A JP 2005235873A JP 2005235873 A JP2005235873 A JP 2005235873A JP 4773157 B2 JP4773157 B2 JP 4773157B2
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- Prior art keywords
- traveling wave
- manipulator
- sample
- specimen
- reagent
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/23—Magnetic separation acting directly on the substance being separated with material carried by oscillating fields; with material carried by travelling fields, e.g. generated by stationary magnetic coils; Eddy-current separators, e.g. sliding ramp
- B03C1/24—Magnetic separation acting directly on the substance being separated with material carried by oscillating fields; with material carried by travelling fields, e.g. generated by stationary magnetic coils; Eddy-current separators, e.g. sliding ramp with material carried by travelling fields
- B03C1/253—Magnetic separation acting directly on the substance being separated with material carried by oscillating fields; with material carried by travelling fields, e.g. generated by stationary magnetic coils; Eddy-current separators, e.g. sliding ramp with material carried by travelling fields obtained by a linear motor
Landscapes
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Sampling And Sample Adjustment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Description
[数1]
fTHRESHOLD=μE/4p
により求めることができる。この式中、Eは進行波の電界強度、pは進行波電極のピッチである。図2に、その分子量が似通っている2個の標本(それぞれ分子量がMW1又はMW2)について、周波数応答曲線を示す。しきい周波数fTHRESHOLDより低い周波数レンジにて発生する同期状態の特徴は、移送速度が高いこと、周波数上昇に対し移送速度が直線的に増加すること、分子量の違いによる移送速度の差が小さいこと等である。従って、同期状態を初期分離に利用すれば、標本乃至種を迅速に分離できる。これに対して、しきい周波数fTHRESHOLDより高い周波数レンジにて発生する非同期状態の特徴は、移送速度が低いこと、分子量の違いによる移送速度の差ΔVが大きいこと等である。従って、非同期状態を利用すれば、分子量が似通っている標本乃至種同士をより精密に分離できる。なお、移送条件をより好適なものにすれば、周波数応答曲線のうちの同期状態部分がより急峻になり、またそのピークがより高くなる。
[数2]
E(w/2)=kT/q
により求めることができる。この式中、Eは進行波の電界強度、wは溶質例えばタンパク質のバンドの幅、kはボルツマン定数、Tは温度、qは電荷である。局所的に電界強度Eが一桁強まると、バンド幅wは最大で1/10程まで狭まる。先に述べた例においては、バンド幅wの最小値は、進行波電極を個別アドレシングする場合は約40μm、グループアドレシングする場合は約160μmである。
[数3]
μ=q/(6pvR)
から、総電荷計算値=16eが得られる。なお、この式中、qは電荷、vは粘度、Rは半径である。またリボゾームの分子量は25MDaである。これらの数値から、本マニピュレータがなぜ個別のタンパク質、例えばその分子量が10〜250kDaで総電荷が単位電荷eの数倍程に小さいタンパク質を錯体に対し相対移動させ得るかを、理解することができよう。錯体の例にはタンパク質錯体、タンパク質核酸錯体、リボゾーム、膜フラグメントのようなタンパク質脂質錯体、小胞体フラグメント、ゴルジ体標本、ウイルス、多酵素錯体、並びにそれらの任意の組合せが含まれる。
Claims (4)
- 基板及びこの基板上に配置された複数個の進行波電極を備えるサンプルマニピュレータを用い標本と試薬とを反応させる方法であって、
前記サンプルマニピュレータ上の第1の位置に前記標本を載せるステップと、
前記サンプルマニピュレータ上の第2の位置に前記試薬を載せるステップと、
前記サンプルマニピュレータの進行波電極に印加する電圧波形について適切な周波数を決定するステップと、
前記決定した周波数を有する電圧波形を前記サンプルマニピュレータの進行波電極に印加することにより静電進行波を発生させ、前記標本及び前記試薬のうち少なくとも一方を他方に接近していくよう動かし反応させるステップと、
を有する方法。 - 請求項1に記載の方法であって、
蛍光染料によりラベリングされた前記標本が前記基板上に固定され、前記試薬が蛍光共鳴エネルギ移動効果を生じる第2の蛍光染料によりラベリングされている方法。 - 請求項2に記載の方法であって、
前記サンプルマニピュレータ上の進行波によって前記試薬が前記標本に接近し、離れることにより、蛍光共鳴エネルギ移動効果が前記試薬と前記標本との間に起こったかどうかを決定する方法。 - 請求項1に記載の方法であって、
前記試薬として二種類の異なる分子が進行波によって動いて、第3の固定された分子である前記標本に接近し、それら3つの分子が相互作用して信号を発生する方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/921,556 US7126134B2 (en) | 2004-08-19 | 2004-08-19 | Sample manipulator |
US10/921,556 | 2004-08-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2006058302A JP2006058302A (ja) | 2006-03-02 |
JP4773157B2 true JP4773157B2 (ja) | 2011-09-14 |
Family
ID=35406990
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005235873A Expired - Fee Related JP4773157B2 (ja) | 2004-08-19 | 2005-08-16 | サンプルマニピュレータ |
Country Status (3)
Country | Link |
---|---|
US (1) | US7126134B2 (ja) |
EP (1) | EP1628130B1 (ja) |
JP (1) | JP4773157B2 (ja) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
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US8304238B2 (en) * | 2003-03-24 | 2012-11-06 | Nat'l Institute for Environmental Studies | Cell culture medium and immobilized preparation of cell adhesion protein or peptide |
JP4792338B2 (ja) * | 2006-07-04 | 2011-10-12 | 株式会社日立製作所 | 液体搬送装置 |
US7764005B2 (en) | 2006-08-08 | 2010-07-27 | Palo Alto Research Center Incorporated | Traveling wave grids with agitated surface using piezoelectric effect and acoustic traveling waves |
US7771580B2 (en) * | 2006-08-30 | 2010-08-10 | Palo Alto Research Center Incorporated | Particle extraction methods and systems for a particle concentrator |
US7448287B2 (en) * | 2006-10-02 | 2008-11-11 | Palo Alto Research Center Incorporated | Pipette with agitation feature |
US8354076B2 (en) * | 2006-10-02 | 2013-01-15 | Palo Alto Research Center Incorporated | Fluid stirring mechanism |
US8854505B2 (en) * | 2008-11-13 | 2014-10-07 | Nikon Corporation | Dust-removal optical device, a dust-removal imaging device, and method of manufacturing an optical device for removing dust |
JP5115538B2 (ja) * | 2008-11-13 | 2013-01-09 | 株式会社ニコン | 光学装置、撮像装置および光学装置の製造方法 |
JP5195330B2 (ja) * | 2008-11-13 | 2013-05-08 | 株式会社ニコン | 光学装置及び撮像装置 |
JP5397043B2 (ja) * | 2009-06-26 | 2014-01-22 | 株式会社ニコン | 光学装置および光学機器 |
US9647523B2 (en) | 2010-12-03 | 2017-05-09 | Sri International | Levitated-micro manipulator system |
US8593016B2 (en) * | 2010-12-03 | 2013-11-26 | Sri International | Levitated micro-manipulator system |
WO2016142681A1 (en) | 2015-03-06 | 2016-09-15 | Micromass Uk Limited | Spectrometric analysis of microbes |
CN107646089B (zh) | 2015-03-06 | 2020-12-08 | 英国质谱公司 | 光谱分析 |
WO2016142674A1 (en) | 2015-03-06 | 2016-09-15 | Micromass Uk Limited | Cell population analysis |
US10861627B2 (en) | 2015-04-20 | 2020-12-08 | Sri International | Microrobot and microrobotic train self-assembly with end-effectors |
GB201517195D0 (en) * | 2015-09-29 | 2015-11-11 | Micromass Ltd | Capacitively coupled reims technique and optically transparent counter electrode |
WO2017178833A1 (en) | 2016-04-14 | 2017-10-19 | Micromass Uk Limited | Spectrometric analysis of plants |
EP3631414A4 (en) * | 2017-05-22 | 2021-03-10 | Bioelectronica Corporation | ASSAY SYSTEMS AND METHODS FOR PROCESSING SAMPLE ENTITIES |
WO2020076872A1 (en) | 2018-10-08 | 2020-04-16 | Bioelectronica Corporation | Systems and methods for optically processing samples |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
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US4896174A (en) | 1989-03-20 | 1990-01-23 | Xerox Corporation | Transport of suspended charged particles using traveling electrostatic surface waves |
US6149789A (en) * | 1990-10-31 | 2000-11-21 | Fraunhofer Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Process for manipulating microscopic, dielectric particles and a device therefor |
JPH05296894A (ja) * | 1992-04-15 | 1993-11-12 | Nikon Corp | 顕微鏡用試料セルおよびその使用方法 |
NZ331865A (en) | 1996-03-18 | 1999-04-29 | Univ Wales Bangor Change Of Na | Apparatus with electrode arrays for carrying out chemical, physical or physico-chemical reactions |
US5893015A (en) | 1996-06-24 | 1999-04-06 | Xerox Corporation | Flexible donor belt employing a DC traveling wave |
WO1999063332A1 (en) * | 1998-06-05 | 1999-12-09 | Sarnoff Corporation | Apparatus for separating molecules |
US6290342B1 (en) | 1998-09-30 | 2001-09-18 | Xerox Corporation | Particulate marking material transport apparatus utilizing traveling electrostatic waves |
US6294063B1 (en) * | 1999-02-12 | 2001-09-25 | Board Of Regents, The University Of Texas System | Method and apparatus for programmable fluidic processing |
US6134412A (en) | 1999-05-17 | 2000-10-17 | Xerox Corporation | Method for loading dry xerographic toner onto a traveling wave grid |
GB9916848D0 (en) * | 1999-07-20 | 1999-09-22 | Univ Wales Bangor | Travelling wave dielectrophoretic apparatus and method |
JP2001165905A (ja) * | 1999-09-30 | 2001-06-22 | Wako Pure Chem Ind Ltd | 誘電泳動力を用いた物質の分離方法 |
US6272296B1 (en) | 1999-12-10 | 2001-08-07 | Xerox Corporation | Method and apparatus using traveling wave potential waveforms for separation of opposite sign charge particles |
US6137979A (en) | 1999-12-10 | 2000-10-24 | Xerox Corporation | Toner transport using superimposed traveling electric potential waves |
US6219515B1 (en) | 1999-12-17 | 2001-04-17 | Xerox Corporation | Vibrating travel wave grid |
EP1263532A2 (en) * | 2000-03-16 | 2002-12-11 | Sri International | Microlaboratory devices and methods |
US6246855B1 (en) | 2000-05-30 | 2001-06-12 | Xerox Corporation | Apparatus for loading dry xerographic toner onto a traveling wave grid |
WO2002036464A1 (en) | 2000-11-03 | 2002-05-10 | Technology Innovations, Llc | Powder conveying and dispensing method and apparatus using traveling wave transport |
US6351623B1 (en) | 2000-11-27 | 2002-02-26 | Xerox Corporation | Toner dispensing apparatus employing a traveling wave transport grid |
US6706163B2 (en) | 2001-03-21 | 2004-03-16 | Michael Seul | On-chip analysis of particles and fractionation of particle mixtures using light-controlled electrokinetic assembly of particles near surfaces |
GB0129374D0 (en) * | 2001-12-07 | 2002-01-30 | Univ Brunel | Test apparatus |
JP4039201B2 (ja) * | 2002-08-20 | 2008-01-30 | ソニー株式会社 | ハイブリダイゼーション検出部とセンサーチップ及びハイブリダイゼーション方法 |
US7156970B2 (en) * | 2003-06-12 | 2007-01-02 | Palo Alto Research Center Incorporated | Distributed multi-segmented reconfigurable traveling wave grids for separation of proteins in gel electrophoresis |
US7309410B2 (en) * | 2003-12-03 | 2007-12-18 | Palo Alto Research Center Incorporated | Traveling wave grids and algorithms for biomolecule separation, transport and focusing |
-
2004
- 2004-08-19 US US10/921,556 patent/US7126134B2/en active Active
-
2005
- 2005-08-10 EP EP05254973.0A patent/EP1628130B1/en not_active Ceased
- 2005-08-16 JP JP2005235873A patent/JP4773157B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2006058302A (ja) | 2006-03-02 |
EP1628130A1 (en) | 2006-02-22 |
EP1628130B1 (en) | 2016-03-09 |
US7126134B2 (en) | 2006-10-24 |
US20060038120A1 (en) | 2006-02-23 |
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