JP4765057B2 - PTP package and manufacturing method thereof - Google Patents

Description

  The present invention relates to a method for manufacturing a package including a thermoplastic resin layer including a container for individually storing a drug such as a tablet and food such as confectionery, and a metal thin film that seals an opening of the thermoplastic resin layer. More specifically, the present invention relates to a method for manufacturing a PTP (Press Through Packaging) package.

  In the pharmaceutical packaging field, a PTP package for packaging solid tablets such as tablets and capsules is basically composed of a molding material thin film such as a thermoplastic resin layer and a lid material such as aluminum foil. Yes.

  1 and 2 show schematic perspective views of the PTP package. As described above, the PTP package 1 is composed of the molding material thin film 10 and the lid material 40. The molding material thin film 10 includes a storage portion 20 that stores tablets and the like, and a cutout portion 30 for facilitating division of the storage portion 20. Here, as the molding material thin film 10, a thermoplastic resin is usually used.

  FIG. 3 shows a schematic plan view of the PTP package. In the PTP package 1 shown in FIG. 3, a package having two accommodating portions 20 in parallel with the cutout portions 30 is illustrated, but the number of the accommodating portions 20 can be arbitrarily changed. With such a configuration, the PTP package includes a packaging form that can be pushed out from the storage unit 20 side to break the lid member 40 and take out the contents tablets and the like.

  As the molding material thin film of the PTP package, a hard polyvinyl chloride thin film is mainly used because it is excellent in moldability, stiffness, cost, chemical resistance, gas barrier properties, and the like. However, recently, the use of a polypropylene thin film is becoming mainstream from the viewpoint of environment and disposal (for example, see Patent Document 1).

  By the way, the manufacturing process of the PTP package mainly includes (1) a step of heating a polypropylene film, which is a thermoplastic resin, to form a container, and (2) a step of filling a drug such as a solid preparation, 3) Heat sealing the aluminum foil, which is a lid, and sealing the medicine in the container; (4) Forming a notch for dividing the medicine etc. into one tablet, and making the package an appropriate length And a step of cutting.

Since the above-mentioned polypropylene improves various physical properties by stretching, biaxially stretched polypropylene is used in addition to unstretched polypropylene. Here, stretching refers to aligning polypropylene molecules along the stretching direction by performing an operation of heating at a temperature equal to or lower than the melting point and stretching the film in a certain direction and then rapidly cooling it. In general, stretched polypropylene has characteristics such as high strength and elastic modulus and high gas barrier properties. On the other hand, the stretched polypropylene has a characteristic that the tearing strength in the direction perpendicular to the stretching is extremely high although it is easy to tear in the stretching direction. In addition, when polypropylene is reheated, the stretched polypropylene molecule tends to return to its original state, so that a remarkable stretching phenomenon occurs.
JP 2002-321710 A

  On the other hand, as illustrated in FIGS. 1 to 3, the PTP package 1 is provided with a notch 30 so that the accommodating parts 20 including tablets and the like can be separated one by one. As described above, by changing from polyvinyl chloride to polypropylene as the molding material thin film 10, when polypropylene is used, it may be difficult to separate the notched portion 30 by bending compared to polyvinyl chloride. .

  Under such background, a first object of the present invention is to provide a method for producing a PTP package having good splitting properties at the notch of the PTP package. The second object of the present invention is to provide a PTP package having good splitting properties at the notch.

  Then, in view of the above problems, the present inventor has intensively studied a method for manufacturing a PTP package, and as a result, when forming a storage part of the PTP package, one storage part and a storage part adjacent to the one storage part. The region where the notch is to be formed is heated in advance, and then the accommodating portion is formed to obtain the knowledge that the notch has excellent splitting properties, and the present invention has been completed.

  That is, according to the first aspect of the present invention, a thermoplastic resin layer having at least two notches and a housing portion disposed between the two notches, and the thermoplastic resin layer A method of manufacturing a PTP package comprising: a metal thin film laminated on an opening of the housing portion; (1) a heating step of heating the thermoplastic resin layer; and (2) forming the housing portion. As described above, a molding step for molding the heated thermoplastic resin layer by the housing part molding die, (3) a filling step for filling the housing part with a medicine, and (4) heat sealing the metal thin film In the manufacturing method including a sealing step of sealing a medicine in the housing portion, and (5) a forming step of forming the notch portion in the thermoplastic resin layer, prior to the step (1), the thermoplastic resin layer A manufacturing method including a preheating process for preheating That. By providing such a preheating step, when the accommodating portion is molded in the step (2), the region corresponding to the notch portion is preheated and then gradually cooled, whereby the thermoplastic resin layer is It is presumed that the crystallization of the region proceeds and a notched portion that is hard but easily broken is formed.

  In a preferred aspect of the manufacturing method according to the present invention, the preheating step is executed by hot air providing means for sending hot air to the thermoplastic resin layer from the side on which the metal thin film is formed on the thermoplastic resin layer. By adopting such hot air providing means, it becomes possible to heat the region of the thermoplastic resin layer where the notch is formed.

  In a preferred aspect of the manufacturing method according to the present invention, the hot air providing means includes a hot air source and an enclosure connected to the hot air source so that the hot air is uniformly sent from the hot air source to the thermoplastic resin layer. With. With this configuration, the thermoplastic resin layer that flows during the manufacturing process can be uniformly heated.

  In a preferred aspect of the manufacturing method according to the present invention, the preheating step is executed by a heat retaining chamber from the side on which the metal thin film is formed on the thermoplastic resin layer. Using such a heat retaining chamber, it is possible to heat the region of the thermoplastic resin layer where the notch is formed.

  In the preferable aspect of the manufacturing method which concerns on this invention, the said formation process (2) is performed by the some heating convex part for heating the area | region corresponded to the said accommodating part. By using such a heating convex portion, the accommodating portion can be efficiently formed in the thermoplastic resin layer.

  According to the second aspect of the present invention, (a) a heating step of heating the thermoplastic resin layer, and (b) the thermoplastic resin heated by the housing part mold so as to form the housing part. A molding step of molding a layer, (c) a filling step of filling the container with a drug, and (d) heat-sealing the metal thin film laminated on the opening of the container of the thermoplastic resin layer, In the manufacturing method including a sealing step of sealing the medicine in the housing portion, and (e) a forming step of forming a notch in the thermoplastic resin layer, prior to the step (a), the thermoplastic resin layer The PTP package manufactured by the manufacturing method including the preheating process which preheats is provided.

  According to a preferred aspect of the PTP package according to the present invention, the preheating step is executed by hot air providing means for sending hot air to the thermoplastic resin layer from the side on which the metal thin film is formed on the thermoplastic resin layer. .

  According to a preferred aspect of the PTP package according to the present invention, the hot air providing means is connected to the hot air source and the hot air source so that the hot air is uniformly sent from the hot air source to the thermoplastic resin layer. An enclosed body.

  According to a preferred aspect of the PTP package according to the present invention, the preheating step is executed by a heat retaining chamber from the side on which the metal thin film is formed on the thermoplastic resin layer.

  In addition, the term “preheating” used in the present invention refers to heating in advance prior to heating when forming the housing portion of the PTP package.

  According to the manufacturing method which concerns on this invention, the PTP package body which the splitting property in the notch part improved is provided.

  Next, embodiments of the present invention will be described with reference to the drawings. The following embodiment is an example for explaining the present invention, and is not intended to limit the present invention only to this embodiment. The present invention can be implemented in various forms without departing from the gist thereof.

  FIG. 4 is a schematic side view of a manufacturing apparatus that executes the manufacturing method according to the present invention. As shown in FIG. 4, an original fabric roll 120 around which a thermoplastic resin layer 110 that is a molding material thin film constituting a PTP package is wound is rotatably arranged on the upstream side of the manufacturing apparatus 100. The thermoplastic resin layer 110 is continuously drawn out from the original fabric roll 120, and is subjected to a heat treatment for forming a housing portion. The material of the thermoplastic resin layer used in the present invention is not limited to the following, but from the viewpoint of transparency, mechanical strength, and heat resistance as a package, polyethylene, polypropylene, polystyrene, polyethylene terephthalate, etc. Of these, polypropylene is particularly preferable. The thickness of the thermoplastic resin layer used in the present invention is not particularly limited, but is preferably 100 to 500 μm, more preferably 200 to 400 μm, and further preferably 250 to 350 μm. . And the heat processing by this invention is comprised from the preheating process of only one side of a thermoplastic resin, and (2) the heating process of both surfaces of a thermoplastic resin so that it may mention later.

  FIG. 5 is a flowchart showing the steps of the manufacturing method according to the present invention. As shown in FIG. 5, in step S10, only one surface of the thermoplastic resin layer 110 is subjected to the preheat treatment according to the present invention. Thereafter, in step S11, the thermoplastic resin layer 110 is directly sandwiched between the upper and lower plates of the heating plate 140 in order to heat-treat both surfaces of the thermoplastic resin layer 110 corresponding to the housing portion in the PTP package. Subsequently, in order to form the accommodating part 160 of a PTP package, the heated thermoplastic resin layer 110 is shape | molded by the accommodating part shaping | molding die 150 (refer process S12). The container 160 formed in this way is filled with a solid medicine (not shown in FIG. 4, refer to step S13), and as shown in step S14, the metal thin film 170 as a lid is formed on the thermoplastic resin layer. 110 is supplied so as to cover the opening of the accommodating portion 160, and is heat-sealed to the thermoplastic resin layer through the non-accommodating portion region portion of the thermoplastic resin layer 110, thereby sealing the medicine in the accommodating portion 160 (step S14). reference). This heat sealing is performed by the action of a roller 175 (see FIG. 4) containing a heater (not shown) shown in FIG. 4 and a roller 176 having a concave portion aligned with the accommodating portion 160 on the surface.

  As the material of the metal foil film, it is preferable to select a material with good extrudability because the container of the PTP package is pressed to break the metal thin film as the lid material and push out the drug and the like. Specifically, hard aluminum etc. are mentioned as a material with favorable extrudability. Although the thickness of the metal thin film used by this invention is not specifically limited, It is preferable that it is 10-50 micrometers, It is more preferable that it is 15-40 micrometers, It is further more preferable that it is 20-35 micrometers.

  Next, in step S15, a notch (not shown in FIG. 4) is formed by an appropriate cutting means 180, and necessary information is stamped on the thermoplastic resin layer 110 by a stamping device 190 that prints the date of manufacture. The Thereafter, the PTP package sealed with the drug is cut to a desired length.

(First embodiment of the present invention)
With reference to FIG. 4 again, a first embodiment of the present invention using hot air providing means will be described. By the hot air providing means 130 according to the present invention, preheating is performed from one surface of the thermoplastic resin layer 110 without directly contacting the thermoplastic resin layer 110. The temperature of this pre-heat treatment is, for example, 70 ° C. to 155 ° C., more preferably 85 ° C. to 145 ° C., and further preferably 100 ° C. to 140 ° C. as the outlet temperature in the hot air apparatus. FIG. 6 shows a schematic perspective view of the hot air providing means 130 according to the present invention. As shown in FIG. 6, the hot air providing means 130 according to the present invention includes a hot air source 200 and an enclosure 210 that controls the direction of the hot air of the hot air source 200. By providing the enclosure 210, the hot air from the hot air source 200 can be sent uniformly to the thermoplastic resin layer 110 flowing from the upstream side to the downstream side of the manufacturing apparatus 100 according to the present invention. Become. Although not shown in FIG. 6, the temperature of the hot air can be controlled by disposing a temperature sensor at the lowermost end of the enclosure. Furthermore, although FIG. 6 illustrates the configuration in which two hot air sources 200 are arranged, one or three or more hot air sources may be arranged.

  Next, the thermoplastic resin layer 110 that has been preheated as described above passes through the heating plate 140 in order to heat both surfaces of the portion corresponding to the accommodating portion of the layer 110. At this time, either the upper plate or the lower plate of the heating plate 140 or both of them move up and down, and the thermoplastic resin 110 is sandwiched between the convex portion of the upper plate and the convex portion of the lower plate, and intermittently corresponds to the accommodating portion. Heat both sides of the part. The temperature of the heating plate is 125 ° C to 150 ° C, more preferably 130 ° C to 145 ° C, and still more preferably 135 ° C to 140 ° C. When the temperature is 120 ° C. or lower, the housing portion may be difficult to form when molding the housing portion, which will be described later. When the temperature is 155 ° C. or higher, the thermoplastic resin layer may be melted, making it difficult to mold the housing portion. . After that, as shown in Step 12 of FIG. 5, the thermoplastic resin layer 100 sufficiently heated by the heating plate forms the accommodating portion 160 in the thermoplastic resin layer 110 by the action of the accommodating portion molding die 150.

  FIG. 7 shows a schematic side view of the housing mold 150 used in the present invention. The housing portion molding die 160 used in the present invention is composed of an upper molding portion 162 and a lower molding portion 164, and the upper molding portion 162 has a plurality of convex portions so as to correspond to the housing portion to be formed. . Then, while the thermoplastic resin layer 110 passes between the upper molded portion 162 and the lower molded portion 164, any one of the molded portions 162 and 164 moves up and down, and the thermoplastic resin layer 110 is predetermined. The accommodating portion 160 is formed in contact with and away from the position. In addition, when the shape of the chemical | medical agent etc. which are accommodated is considered, it is preferable that the convex part shown in FIG. 7 is a substantially cylindrical convex part.

(Second embodiment of the present invention)
FIG. 8 is a diagram for explaining a second embodiment of the manufacturing method according to the present invention. 8 shows an enlarged view of the preheating process using the heat insulation chamber 300, unlike the hot air providing means 130 shown in FIG. 4, and the processes after the heat treatment by the heating plate 140 (see step S11 in FIG. 5). Are omitted since they are common to the first embodiment of the present invention.

  The thermoplastic resin layer 110 delivered from the raw roll 120 is preheated in the heat retaining chamber 300 according to the present invention without directly contacting the chamber. The heat retaining chamber 300 includes a heating element 320 using far infrared rays or the like as a heating means, and can be controlled by setting the atmospheric temperature in the chamber to a constant temperature. For example, in FIG. 9, the heating element is installed on the top surface of the chamber, but is not particularly limited, and can be installed on the side surface in the chamber. In addition, the heating element may be a plate type or a tube type, and they can be installed inside the chamber continuously or intermittently. Specific examples of the heating element 320 include an electric ceramic heater (Noritake Co., Ltd.), an oil heater, a steam heater, and the like as a far infrared heater. A near infrared heater (USHIO Inc.) such as a halogen lamp can be used. The temperature in the chamber at this time may be the same as the hot air outlet temperature. In addition, in the present invention, it is possible to attach fins that circulate the atmosphere in the chamber.

  Here, in the 1st and 2nd embodiment by this invention, when the accommodating part 160 is formed in the thermoplastic resin layer 110, the area | region in which an accommodating part is not formed by the above-mentioned preheating process is heated, and the accommodating part 160 is also heated. Is formed. And after the formation of the accommodating part 160, the thermoplastic resin layer 110 is cooled to room temperature. In the region where the accommodating portion 160 is not formed by the preheating process, a heat history at an appropriate temperature is added as compared with the thermoplastic resin not subjected to the preheating process. Here, using the heating plate 140, heating other portions simultaneously with the heating of the housing portion forming portion is only instantaneous heating and a sufficient effect cannot be obtained. In this case, if the temperature of the heating plate 140 is increased in order to add a heat history, or if the heating time in the heating plate 140 is sufficiently long, the moldability of the housing portion is affected, and the PTP package is easily curled. The productivity will also be significantly reduced. On the other hand, the preheating step according to the present invention can achieve the object of the present invention without lowering the productivity, ensuring the formability of the accommodating portion, and preventing the curling property of the sheet.

  Considering from the normal crystallization process of the polymer film, generally, when the resin layer is rapidly heated and rapidly cooled, crystals of molecules constituting the resin hardly grow, so that a flexible resin layer is formed. On the other hand, when the resin layer is sufficiently heated and then slowly cooled, the crystals of the components constituting the resin are likely to grow, so that a resin layer that is hard and brittle, that is, easily cracked is formed. In the present invention, by adopting a preheating step prior to the heating and molding step, the thermoplastic resin layer other than the region in which the housing portion is to be formed is gradually cooled, so that it is given a hard and brittle property. Guessed. In the present invention, by providing a notch portion, which will be described later, in a region where the thermoplastic resin layer is gradually cooled after heating, that is, between the accommodating portion and the adjacent accommodating portion, it is possible to obtain a property of being easily broken by bending. .

  FIG. 10 shows a schematic cross-sectional view of a notch formed in the present invention. FIG. 10 shows a sectional view in the thickness direction of the thermoplastic resin. The notch 30 is provided in the thermoplastic resin layer 110, and a lower part of the notch 30 is formed in the metal thin film 170 that functions as a lid. Preferably not. The notch 30 functions as a “trigger” when dividing the housing 160 (not shown in FIG. 10).

  The present invention will be described in more detail with reference to the following examples, but the scope of the present invention is not limited thereto. Various changes and modifications can be made by those skilled in the art based on the description of the present invention, and these changes and modifications are also included in the present invention.

(Evaluation methods)
The splitting property of the notch in the PTP sheet manufactured by the manufacturing method according to the present invention was performed as follows. That is, with the PTP sheet containing part side up and holding with both hands so as to sandwich the notch part to be divided, the state of the sheet when folded once on the aluminum side and then folded again on the polypropylene side, Evaluated as separability. As a test sample, 20 sheets were used, and five notches were formed per sheet, for a total of 100 notches. At this time, for each notch, the ratio of the length of the notch that could be divided with respect to the total length of the notch was determined, and the ratios were totaled.

Example 1
A PTP sheet was produced using a PTP filling machine having the production line configuration shown in FIG. In this example, in order to use for the test, the medicine was not filled into the container. The conditions of the PTP sheet were as follows. The shape of the PTP sheet: long side 10 cm x short side 4 cm, the number of accommodating parts 10 (2 x 5 rows), and an ear part 420 having no accommodating part at one end (see FIG. 11). Cutout portion: 5 lines perpendicular to the long side, shape of the housing portion: oval shape (for hard capsule), major axis 17 mm x minor axis 4 mm x depth 5 mm. Moreover, the conditions of each apparatus of a production line were as follows. Heating plate and container forming machine; sheet heating temperature (container) 130 to 140 ° C., heat sheet drum; seal temperature 230 ° C., excision part; hot blade temperature 94 ° C. Hot air supply means; hot air source 3600 W x 2 units, distance between enclosure and sheet; 5 cm, outlet temperature of enclosure (outlet central part of enclosure) 83 to 146 ° C. Cover material: Aluminum foil, thickness 0.02 mm, width 195 mm, total length 1000 m, original coil, made by Toyo Aluminum. Polypropylene sheet film: Polypropylene single layer sheet, thickness 0.3 mm, width 200 mm, full length 300 m original fabric coil, trade name Sumilite, NS-3450 (manufactured by Sumitomo Bakelite) was used. When the crystallinity of this sheet was measured, the crystallinity was 22.

  FIG. 12 is a diagram showing the evaluation results of the splitability of the PTP sheet produced in Example 1 of the present invention. In particular, the results of PTP sheet splitting were compared while comparing with the case of no hot air treatment. As is clear from the results shown in FIG. 12, the splitting property of the PTP sheet was improved by applying the hot air treatment, in contrast to the case where the hot air was not applied to the PTP sheet. 12 indicates that the greater the value, the better the partitionability. On the other hand, curl property (particularly, a phenomenon in which the polypropylene layer is warped), which is a problem in the PTP production line, was not recognized at all, and good productivity was exhibited.

Example 2
A PTP sheet was produced using a PTP filling machine having the production line configuration of FIG. In this example, in order to use for the test, the medicine was not filled into the container. The conditions of the PTP sheet were as follows. The shape of the PTP sheet: long side 10 cm x short side 4 cm, the number of accommodating parts 10 (2 x 5 rows), and an ear part 420 having no accommodating part at one end (see FIG. 11). Cutout portion: 5 lines perpendicular to the long side, shape of the housing portion: oval shape (for hard capsule), major axis 17 mm x minor axis 4 mm x depth 5 mm. Moreover, the conditions of each apparatus of a production line were as follows. Heating plate and container forming machine; sheet heating temperature (container) 130 to 140 ° C., heat sheet drum; seal temperature 230 ° C., excision part; hot blade temperature 57 ° C. 97 ° C when hot air supply means is not used. Hot air supply means; hot air source 3600 W x 2 units, distance between the enclosure and the sheet; 5 cm, outlet temperature of the enclosure (outlet central part of the enclosure) 72 to 156 ° C. Cover material: Aluminum foil, thickness 0.02 mm, width 195 mm, total length 1000 m, original coil, made by Toyo Aluminum. Polypropylene sheet film: Polypropylene single layer sheet, thickness 0.3 mm, width 200 mm, full length 300 m original fabric coil, trade name Sumilite, PX413 (manufactured by Sumitomo Bakelite) was used. When the crystallinity of this sheet was measured, it was 44.

  FIG. 13 shows the evaluation results of the splitting property of the PTP sheet produced in Example 2 of the present invention. The splitting properties of the PTP sheets were compared using the case where no hot air treatment was performed as a control. From the results shown in FIG. 13, by performing the hot air treatment, the splitting property of the PTP sheet was improved as compared with the case where the hot air was not applied to the PTP sheet. Moreover, curl property which is a problem of the production line of PTP was not recognized at all, and good manufacturability was shown.

Example 3
A PTP sheet was produced using a PTP filling machine having the production line configuration of FIG. In this example, in order to use for the test, the medicine was not filled into the container. The conditions of the PTP sheet were as follows. The shape of the PTP sheet: long side 10 cm x short side 4 cm, the number of accommodating parts 10 (2 x 5 rows), and an ear part 420 having no accommodating part at one end (see FIG. 11). Cutout portion: 5 lines perpendicular to the long side, shape of the storage portion: cylindrical shape (for tablets), diameter 10 mm x depth 5 mm. Moreover, the conditions of each apparatus of a production line were as follows. Heating plate and container forming machine; sheet heating temperature (container) 130 to 140 ° C., heat sheet drum; seal temperature 230 ° C., excision part; hot blade temperature 125 ° C. Hot air supply means; hot air source 3600 W x 2 units, distance between the enclosure and the sheet; 5 cm, outlet temperature of the enclosure (outlet central part of the enclosure) 72 to 156 ° C Cover material: Aluminum foil, thickness 0.02 mm, width 195 mm, total length 1000 m, original coil, made by Toyo Aluminum. Polypropylene sheet film: Polypropylene single layer sheet, thickness 0.3 mm, width 200 mm, total length 300 m raw fabric coil, trade name Sumilite, PX368 (manufactured by Sumitomo Bakelite) was used. The crystallinity of this sheet was measured and found to be 41.

  FIG. 14 shows the evaluation results of the splitability of the PTP sheet produced in Example 3 of the present invention. The test was conducted on 2 lots of polypropylene film sheets, and the average value was calculated. The splitting properties of the PTP sheets were compared with a case where no hot air treatment was performed as a control. As is clear from the results shown in FIG. 14, the splitting property of the PTP sheet was improved by performing the hot air treatment as compared with the case where the hot air was not applied to the PTP sheet. On the other hand, the curl property which is the subject of the production line of PTP was not recognized at all, and good manufacturability was shown.

Example 4
A PTP sheet was produced using a PTP filling machine having the production line configuration of FIG. In this example, in order to use for the test, the medicine was not filled into the container. The conditions of the PTP sheet were as follows. The shape of the PTP sheet: long side 10 cm x short side 4 cm, the number of accommodating parts 10 (2 x 5 rows), and an ear part 420 having no accommodating part at one end (see FIG. 11). Cutout portion: 5 lines perpendicular to the long side, shape of the housing portion: oval shape (for hard capsule), major axis 18.5 mm x minor axis 8.2 mm x depth 6.3 mm. Moreover, the conditions of each apparatus of a production line were as follows. Heating plate and container forming machine; sheet heating temperature (container) 130 to 140 ° C., heat sheet drum; seal temperature 230 ° C., excision part; hot blade temperature 80 ° C. Hot air supply means; hot air source 3600 W x 2 units, distance between the enclosure and the sheet; 5 cm, outlet temperature of the enclosure (outlet central part of the enclosure) 72 to 156 ° C. Cover material: Aluminum foil, thickness 0.02 mm, width 195 mm, total length 1000 m, original coil, made by Toyo Aluminum. Polypropylene sheet film: Polypropylene single layer sheet, thickness 0.3 mm, width 200 mm, full length 300 m original fabric coil, trade name Sumilite, PX413 (manufactured by Sumitomo Bakelite) was used. When the crystallinity of this sheet was measured, it was 44.

  FIG. 15 shows the evaluation results of the splitability of the PTP sheet created in Example 4. It was confirmed that the splitting property was improved by performing the hot air treatment in contrast to the case where the heat treatment was not performed as in Examples 1 to 3. Further, as a comparative example, as an alternative heating method for hot air treatment, a heating plate that can heat the entire surface of the heating plate including notches as well as a heating plate that heats only the housing portion used in the heating step of Example 4 (no protrusion) A PTP sheet was produced instead of the flat plate. That is, in the comparative example as well as in the fourth embodiment, the housing portion is heated on both sides, but only the opposite surface where the cutout portion is to be formed is heated except for the main portion. However, in the comparative example, improvement in splitting property was not recognized. Further, the PTP sheet produced in the comparative example also curled.

  From the above results, it was confirmed that the hot air treatment was excellent as a heating means for the film sheet for improving the splitting property.

FIG. 1 shows a schematic perspective view of a PTP package without a lid. FIG. 2 shows a schematic perspective view of a PTP package including a lid. FIG. 3 is a schematic plan view of the PTP package. FIG. 4 is a schematic side view of a manufacturing apparatus for executing the first embodiment of the manufacturing method according to the present invention. FIG. 5 shows a flowchart of each step of the manufacturing method according to the present invention. FIG. 6 shows a schematic perspective view of hot air providing means used in the present invention. The arrows shown in FIG. 6 indicate the direction in which the thermoplastic resin layer flows. FIG. 7 shows a schematic side view of a housing mold used in the present invention. FIG. 8 is an enlarged view of the preheat treatment of the present invention in the second embodiment of the production method according to the present invention. FIG. 9 shows a schematic cross-sectional view along line A-A ′ of FIG. 8. FIG. 10 shows a schematic cross-sectional view of a notch formed in the present invention. FIG. 11 is a schematic front view of the shape of the PTP sheet used in the example of the present invention, and has an ear portion that does not have a storage portion at one end portion. FIG. 12 shows the evaluation results of the splitting property of the PTP sheet produced in Example 1 of the present invention. FIG. 13 shows the evaluation results of the splitting property of the PTP sheet produced in Example 2 of the present invention. FIG. 14 shows the evaluation results of the splitability of the PTP sheet produced in Example 3 of the present invention. FIG. 15 shows the evaluation results of the splitting property of the PTP sheet produced in Example 3 of the present invention, together with a comparative example.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 ... PTP package body, 10 ... Molding material thin film, 20 ... Housing part, 30 ... Notch part, 40 ... Cover material, 1000 ... Manufacturing apparatus which performs the manufacturing method which concerns on this invention, 110 ... Thermoplastic resin layer, 120 ... Raw material roll, 130 ... hot air providing means, 140 ... heating plate, 150 ... housing part molding die, 160 ... housing part, 162 ... upper molding part, 164 ... lower molding part, 166 ... top part, 170 ... metal thin film, 175 ... Roll: 176: Roller having a recess, 180: Cutting means, 190 ... Marking device, 200 ... Hot air source, 210 ... Enclosure, 300 ... Insulation chamber, 320 ... Heating element, 420 ... Ear part

Claims (9)

A thermoplastic resin layer having at least two notches, and an accommodating portion disposed between the two notches, and a metal thin film laminated on an opening of the accommodating portion of the thermoplastic resin layer. A method for producing a PTP package comprising:
(1) a heating step of heating the thermoplastic resin layer;
(2) a molding step of molding the heated thermoplastic resin layer by a housing part mold so as to form the housing part;
(3) a filling step of filling the container with a medicine;
(4) a sealing step of heat-sealing the metal thin film to seal the drug in the container;
(5) In the manufacturing method including the forming step of forming the notch in the thermoplastic resin layer,
Prior to the step (1), seen including a preheating step of preheating the thermoplastic resin layer, wherein the preheating step, from the side where the metal thin film is formed on the thermoplastic resin layer, and sends the heated air to the thermoplastic resin layer The manufacturing method which is performed by the hot air providing means, one surface of the thermoplastic resin layer is preheated, and both surfaces of the thermoplastic resin layer are heated . The manufacturing method according to claim 1 , wherein the hot air providing unit includes a hot air source and an enclosure connected to the hot air source so that the hot air is uniformly sent from the hot air source to the thermoplastic resin layer. Method. The manufacturing method of Claim 2 with which a hot air is sent uniformly with respect to the thermoplastic resin layer which flows from an upstream side to a downstream side. A thermoplastic resin layer having at least two notches, and an accommodating portion disposed between the two notches, and a metal thin film laminated on an opening of the accommodating portion of the thermoplastic resin layer. A method for producing a PTP package comprising:
(1) a heating step of heating the thermoplastic resin layer;
(2) a molding step of molding the heated thermoplastic resin layer by a housing part mold so as to form the housing part;
(3) a filling step of filling the container with a medicine;
(4) a sealing step of heat-sealing the metal thin film to seal the drug in the container;
(5) In the manufacturing method including the forming step of forming the notch in the thermoplastic resin layer,
Prior to the step (1), a preheating step of preheating the thermoplastic resin layer is included, and the preheating step is executed by a heat insulation chamber from the side on which the metal thin film is formed on the thermoplastic resin layer, and the thermoplastic resin A production method , wherein one side of the layer is preheated and both sides of the thermoplastic resin layer are heated . The manufacturing method according to any one of claims 1 to 4, wherein the preheating step is a step of adding a thermal history at an appropriate temperature.   The manufacturing method according to any one of claims 1 to 5, wherein the forming step (2) is performed by a plurality of heating projections for heating a region corresponding to the housing portion. (A) a heating step of heating the thermoplastic resin layer;
(B) a molding step of molding the heated thermoplastic resin layer by a housing part mold so as to form a housing part;
(C) a filling step of filling the container with a medicine;
(D) a sealing step of heat-sealing the metal thin film laminated on the opening of the housing portion of the thermoplastic resin layer and sealing the drug in the housing portion;
(E) a forming step of forming a notch in the thermoplastic resin layer,
Wherein prior to step (a), the saw including a preheating step of preheating the thermoplastic resin layer, wherein the preheating step, from the side where the metal thin film is formed on the thermoplastic resin layer, the hot air to the thermoplastic resin layer A PTP package manufactured by a manufacturing method , which is executed by a hot air supplying means to be sent, and one surface of the thermoplastic resin layer is preheated and both surfaces of the thermoplastic resin layer are heated .   The PTP according to claim 7, wherein the hot air providing means includes a hot air source and an enclosure connected to the hot air source so that the hot air is uniformly sent from the hot air source to the thermoplastic resin layer. Packaging body. (A) a heating step of heating the thermoplastic resin layer;
(B) a molding step of molding the heated thermoplastic resin layer by a housing part mold so as to form a housing part;
(C) a filling step of filling the container with a medicine;
(D) a sealing step of heat-sealing the metal thin film laminated on the opening of the housing portion of the thermoplastic resin layer and sealing the drug in the housing portion;
(E) a forming step of forming a notch in the thermoplastic resin layer,
Prior to the step (a), the method includes a preheating step of preheating the thermoplastic resin layer, and the preheating step is performed by a heat retaining chamber from a side on which a metal thin film is formed on the thermoplastic resin layer, and the thermoplastic A PTP package manufactured by a manufacturing method in which one surface of a resin layer is preheated and both surfaces of the thermoplastic resin layer are heated .

Images