JP4750539B2 - Radiopharmaceutical dispensing device - Google Patents

Description

  The present invention relates to a dispensing device for a radioactive drug solution.

A nuclear medicine diagnostic method for diagnosing diseases and the like by administering a radiopharmaceutical solution containing a compound labeled with a radionuclide (RI) into the body and imaging the state in which the labeled compound is collected at a specific location in the body with a dedicated device. Has been developed. In this diagnostic method, a relatively short-lived radionuclides (e.g., as a positron-emitting nuclide, ¹³ N 10 min, ¹¹ C is 20 minutes, ¹⁸ F has a half-life of 110 minutes) labeled with, ¹³ N -Ammonia, ¹¹ C-methionine, ¹⁸ F-FDG (fluorodeoxyglucose) or the like is used as the radioactive chemical solution.

Conventionally, in order to administer a radioactive drug solution to a subject, for example, a dispensing administration device 20 disclosed in Patent Document 1 has been used. In the case of administering a radiopharmaceutical solution by the dispensing device 20, first, the radioactive drug solution synthesized by the synthesizer is dispensed into the vial bottle 70, and the vial bottle 70 is transported from the synthesizer to the dispensing device 20 to be dispensed. Set in the radiation shielding container 71 of the dosing device 20. Next, a predetermined amount of the radioactive drug solution is dispensed from the vial bottle 70 into the drug solution syringe 82. Then, the drug solution in the drug solution syringe 82 is extruded to be administered to the subject via the attachment needle 52.
JP 2002-306609 A

However, in the conventional method described above, the radioactive drug solution is dispensed from the synthesizer to the vial, the vial is transported to the dispensing device, and the radioactive drug solution is further transferred from the vial to the drug syringe in the dispensing device. Because it was necessary to dispense, it took time to administer to the subjects. Therefore, as described above, when using a radioactive drug solution labeled with ¹³ N having a half-life of 10 minutes or ¹¹ C having a half-life of 20 minutes, the amount of radioactivity was attenuated in a short time and wasted. In addition, since the conventional dispensing apparatus is relatively heavy, it is troublesome to carry to a desired position and the handling is poor.

  The present invention has been made in view of the above-described circumstances, and provides a dispensing device for a radioactive chemical solution that is capable of efficiently dispensing a radioactive chemical solution in a short time and that has excellent handling properties. For the purpose.

A dispensing device for a radioactive chemical solution according to the present invention includes a first container that contains a radioactive chemical solution from a synthesizer, a second container that contains a diluted solution that dilutes the radioactive chemical solution, and the radioactive chemical solution from the first container. A syringe mounting part for removably attaching a syringe as a dispensing destination of a radioactive drug solution for extracting and extracting the diluent from the second container, and a radioactivity amount of the radioactive drug solution dispensed in the syringe and the first container A sensor that measures at least one of the radioactivity levels of the stored radiopharmaceutical solution, and the required amount of the radiopharmaceutical solution is extracted from the first container based on the detection value of the sensor, and the necessary liquid is extracted from the second container. And a syringe driving device for driving the syringe so as to extract an amount of the diluent .

  In this dispensing device, the radioactive chemical solution is introduced from the synthesizer into the first container, and the radioactive chemical solution is directly dispensed to the syringe while measuring the amount of radioactivity by the sensor. Can be used. Therefore, it becomes possible to dispense the radioactive drug solution efficiently in a short time. In addition, since it is the syringe that is moved during administration to the subject, it is not particularly necessary to move heavy objects, and handling can be improved.

  The dispensing apparatus includes a radiation shielding housing having a first storage unit that stores an object, and the first storage unit stores a first container, a second container, a syringe attachment unit, a sensor, and a driving device. And preferred. Thus, by storing each member in the first storage unit, it is possible to make the dispensing device compact and prevent radiation leakage.

  It is preferable that the dispensing device includes a distribution device that extracts the radioactive liquid from the first container and distributes it to the quality verification device, and the distribution device is stored in the first storage unit. Thus, by storing the dispensing device in the first storage unit, the dispensing device can be made more compact.

  The radiation shielding housing preferably has a second storage unit for storing the synthesis device. The dispensing device preferably includes an introduction path that connects the first container of the first storage unit and the synthesis device of the second storage unit and guides the radioactive chemical from the synthesis device to the first container. If it does in this way, a radioactive chemical | medical solution will be directly introduce | transduced into a 1st container via an introduction path from a synthesis | combination apparatus, and the efficiency improvement of dispensing work will be achieved further.

  ADVANTAGE OF THE INVENTION According to this invention, while being able to perform dispensing of a radioactive chemical | medical solution efficiently in a short time, the dispensing apparatus of the radioactive chemical | medical solution excellent in the handleability can be provided.

  Hereinafter, embodiments of the present invention will be described with reference to the drawings. In the following description, the same reference numerals are used for the same elements, and duplicate descriptions are omitted.

  FIG. 1 is a front view schematically showing a configuration of a synthetic dispensing apparatus for a radioactive chemical solution according to the present embodiment. 1A shows an external configuration with the door closed, and FIG. 1B shows an internal configuration with the door removed.

As shown in FIG. 1, the synthetic dispensing apparatus 10 includes a synthesizing apparatus 12 that synthesizes ¹³ N-ammonia as a radioactive chemical solution, and a dispensing apparatus 14 that dispenses the synthesized ¹³ N-ammonia into a syringe. ing.

As shown in FIGS. 1 and 2, the dispensing device 14 includes an undiluted solution vial (first container) 16, a saline container (second container) 18, a syringe attachment unit 20, a sensor 22, and a syringe drive device 24. A distribution device 26, a radiation shield (radiation shielding housing) 28, and an introduction path 30. The stock solution vial 16 contains ¹³ N-ammonia from the synthesizer 12. As shown in FIG. 2, the stock solution vial 16 is a double-ended vial that can introduce ¹³ N-ammonia from the top and extract ¹³ N-ammonia from the bottom. An imaging device 32 is provided above the stock solution vial 16 so that the liquid level can be monitored. Saline vial 18 contains physiological saline as a diluent for diluting ¹³ N-ammonia.

  The stock solution vial 16 and the saline vial 18 are mounted on the Y stage 34 with the take-out port facing downward. The Y stage 34 is mounted on the X stage 36. The X stage 36 is mounted on the base 38. A liner 40 extending in the Y direction is provided below the Y stage 34. On the other hand, a rail 42 extending in the Y direction is provided on the X stage 36. The liner 40 and the rail 42 are slidably fitted, and the Y stage 34 is movable in the Y direction by driving the Y-axis motor 44. A liner 46 extending in the X direction is provided below the X stage 36. On the other hand, a rail 48 extending in the X direction is provided on the base 38. The liner 46 and the rail 48 are slidably fitted, and the X stage 36 can be moved in the X direction by driving the X-axis motor 50.

The syringe attachment portion 20 is provided below the base 38. This syringe attachment part 20 attaches so that the syringe 52 as a dispensing destination of ¹³ N-ammonia can be removed. As shown in FIGS. 2 and 3, the syringe 52 is fixed to an operation handle 58 having a grip portion 54 and a fixing portion 56. The grip part 54 has a handle having a substantially U-shaped cross section, and a fixing part 56 is provided on the upper side surface. The fixing portion 56 is made of a substantially cylindrical radiation shield, and is fixed through the syringe 52 inside. A part of the fixing portion 56 is cut off in the axial direction, and the portion is sealed with lead glass and provided with a window portion (not shown). Thereby, a part of the radiation is allowed to pass through the window, and the radioactivity amount can be measured by the sensor 22. Thus, since the syringe 52 is fixed to the operation handle 58, the syringe mounting portion 20 has a substantially L-shaped base 60 on which the operation handle 58 is mounted. On the upper side surface of the pedestal 60, a detection sensor 62 for detecting reception of the operation handle 58 to which the syringe 52 is fixed is provided.

The sensor 22 is provided on the back of the syringe 52 in FIG. 2 and measures the amount of radioactivity of ¹³ N-ammonia dispensed into the syringe 52. The syringe driving device 24 is controlled by the control device 64 to drive the syringe 52 so as to extract a necessary amount of liquid from the raw solution vial 16 and the saline vial 18 based on the detection value of the sensor 22. The syringe drive device 24 can displace the pedestal 60 itself in the Z direction, and can displace the piston 52 a of the syringe 52 in the Z direction independently of the pedestal 60.

As shown in FIG. 1, the distributor 26 extracts a part of ¹³ N-ammonia from the stock solution vial 16 and distributes it to a quality tester (not shown). The distribution device 26 has five three-way stopcocks 66 and a distribution syringe 68. This dispensing syringe 68 extracts a predetermined amount of ¹³ N-ammonia from the stock solution vial 16, and switches the five-way three-way stopcock 64 as desired to extrude the extracted drug solution from the dispensing syringe 68, to the quality verification device. A sample of ¹³ N-ammonia is sent. The quality verification apparatus is an apparatus for verifying the quality of ¹³ N-ammonia as a radioactive chemical solution, and performs a pH test, a purity test, and the like.

  The radiation shield 28 is a casing having a substantially rectangular parallelepiped shape formed from a radiation shielding medium such as lead, and has a first storage portion 28a provided at the lower stage and a second storage portion 28b provided at the upper stage. is doing. The first and second storage portions 28a and 28b have doors 29a and 29b that can be opened and closed independently, and an operation handle 58 to which a syringe 52 is further fixed is attached to the door 29a of the first storage portion 28a. And the small door 70 for performing removal is provided. And the above-mentioned dispensing apparatus 14 is stored in the 1st storage part 28a. The synthesizing device 12 is stored in the second storage unit 28b. The second storage unit 28b in which the synthesizer 12 is stored is provided with a filter 72 for keeping the room clean.

The introduction path 30 connects the stock solution vial 16 of the first storage unit 28 a and the synthesis device 12 of the second storage unit 28 b, and directly guides ¹³ N-ammonia from the synthesis device 12 to the stock solution vial 16. The introduction path 30 is composed of, for example, a silicone tube.

Next, a method for synthesizing and dispensing ¹³ N-ammonia using the above-described synthesizing and dispensing apparatus 10 will be described.

  First, the synthesis device 12 and the stock solution vial 16 are connected by the introduction path 30, and the three-way cock 64 of the distribution device 26 and the stock solution vial 16 are connected by the tube 74. Further, the three-way cock 64 of the distributor 26 is connected to a quality inspection device (not shown) by a tube 76. And the operation handle 58 which fixed the syringe 52 to the syringe attaching part 20 of the dispensing apparatus 14 is attached.

Next, ¹³ N-ammonia is synthesized in the synthesizer 12 and introduced into the stock solution vial 16 via the introduction path 30. Then, a part of ¹³ N-ammonia is extracted by the distributor 26 and sent to a quality tester (not shown).

  On the other hand, in the first storage portion 28 a, the pedestal 60 is raised in the Z direction by the syringe drive device 24, and the needle of the syringe 52 is pierced into the stock solution vial 16. The stock solution vial 16 is previously positioned at a desired position by the X-axis motor 50 and the Y-axis motor 44, but an XY provided on the lower surface of the Y stage 34 so that the needle pierces the center of the stock solution vial 16. The sensor 78 performs fine positioning in the XY directions. The positioning in the Z direction is performed by a Z sensor 80 provided on the lower surface of the base 38.

Then, the piston 52 a of the syringe 52 is pulled out by the syringe driving device 24, and a predetermined amount of ¹³ N-ammonia is dispensed from the stock solution vial 16. At this time, the radioactivity amount of ¹³ N-ammonia is measured by the sensor 22, and the necessary liquid amount is accurately extracted from the stock solution vial 16 based on the detection value of the sensor 22. Next, the pedestal 60 is lowered by the syringe drive device 24, the needle of the syringe 52 is extracted from the stock solution vial 16, the X stage 36 is moved in the X direction, and the saline vial 18 is positioned immediately above the syringe 52.

Next, the pedestal 60 is raised in the Z direction again by the syringe drive device 24, and the needle of the syringe 52 is pierced into the saline container 18. Next, the piston 52 a of the syringe 52 is pulled out by the syringe driving device 24, and a predetermined amount of physiological saline is extracted from the saline vial 18, and ¹³ N-ammonia is diluted to a predetermined concentration in the syringe 52. Next, the pedestal 60 is lowered by the syringe drive device 24 and the needle of the syringe 52 is extracted from the raw food vial 18.

  And the small door 70 of the 1st storage part 28a is opened, the operation handle 58 which fixed the syringe 52 from the syringe attachment part 20 of the dispensing apparatus 14 is removed, and it uses for a test subject.

As described above in detail, the combining dispensing device 10 according to the present embodiment, synthesizing unit 12 the ¹³ N-ammonia in stock vial 16 is introduced directly from, ¹³ to the syringe 52 while measuring the radioactivity of the sensor 22 N -Ammonia can be directly dispensed, and the syringe 52 can be removed from the syringe mounting portion 20 for administration to a subject. Therefore, it is possible to efficiently dispense ¹³ N-ammonia in a short time. In addition, since it is the syringe 52 that is moved during administration to the subject, it is not particularly necessary to move a heavy object, and the handleability can be improved.

  Further, since the dispensing device 14 is stored in the first storage portion 28a of the radiation shield 28, the dispensing device 14 can be made compact and radiation leakage can be prevented. In addition, since the dispensing device 26 is also stored in the first storage unit 28a, the dispensing device 14 can be further downsized.

Since the synthesizing device 12 is stored in the second storage portion 28b of the radiation shield 28, the synthesizing / dispensing device 10 can be made compact. The stock solution vial 16 in the first storage unit 28a and the synthesizer 12 in the second storage unit 28b are connected to each other by the introduction path 30, so that ¹³ N is supplied from the synthesizer 12 to the stock solution vial 16 through the introduction path 30. -By introducing ammonia directly, the efficiency of dispensing work can be further improved.

The present invention is not limited to the above-described embodiment, and various modifications can be made. For example, in the above-described embodiment, the case where ¹³ N-ammonia is synthesized and dispensed as the radioactive chemical solution has been described. However, the radioactive chemical solution may be ¹¹ C-methionine. As an apparatus configuration in this case, as shown in FIG. 4, a methyl iodide synthesis apparatus 80 is newly added. The second storage portion 28b of the radiation shield 28 may be divided into four, and the methionine synthesizer 12 may be stored in each of the four boxes so as to synthesize continuous methionine. The distribution of methyl iodide into each box is through a distributor 82. The first storage portion 28 a is provided with five three-way stopcock continuum 84, and ¹¹ C-methionine is introduced into the stock solution vial 16 through the three-way stopcock continuum 84.

As the radioactive solution, particularly short half-life ¹³ N and ¹¹ have been ¹³ N-ammonia, ¹¹ C-without being restricted to methionine-labeled in C, and the present invention is longer for example a more half-life ¹⁸ F- The present invention can also be applied to a case where FDG (fluorodeoxyglucose) is synthesized and dispensed.

  The sensor 22 may measure the amount of radioactivity of the radiopharmaceutical contained in the stock solution vial 16. In this way, it is possible to detect the radioactivity amount of the radiopharmaceutical solution dispensed in the syringe 52 from the decrease in the radioactivity amount in the stock solution vial 16. The sensor 22 may measure the amount of radioactivity of both the syringe 52 and the radiopharmaceutical solution stored in the stock solution vial 16. In this way, the amount of radioactivity of the radiopharmaceutical dispensed in the syringe 52 can be detected with higher accuracy.

It is a front view which shows typically the synthetic | combination dispensing apparatus of ¹³ N-ammonia. It is a figure which shows the principal part structure of a dispensing apparatus. It is a front view which shows the operation handle which fixed the syringe. It is a front view which shows typically the synthetic | combination dispensing apparatus of < ¹¹ > C-methionine.

Explanation of symbols

  DESCRIPTION OF SYMBOLS 10 ... Synthetic dispensing apparatus, 12 ... Synthetic apparatus, 14 ... Dispensing apparatus, 16 ... Stock solution vial, 18 ... Saline vial, 20 ... Syringe attachment part, 22 ... Sensor, 24 ... Syringe drive device, 26 ... Dispensing apparatus, 28 ... Radiation shield, 28a ... First storage section, 28b ... Second storage section, 30 ... Introduction path, 52 ... Syringe.

Claims (4)

A first container containing a radioactive chemical solution from the synthesizer;
A second container for containing a diluent for diluting the radioactive drug solution;
The syringe as dispensing destination of the radioactive solution for extracting the diluent from the second container while extracting the radioactive solution from the first container, a syringe mounting portion for mounting detachably,
A sensor for measuring at least one of radioactivity of the radioactive solution contained in the radioactivity level and the first container of the radioactive solution was dispensed into the syringe,
A syringe that drives the syringe so as to extract the required amount of the radioactive chemical from the first container and extract the required amount of the diluent from the second container based on the detection value of the sensor. A driving device;
A dispensing device for a radioactive chemical solution, comprising: A radiation shielding housing having a first storage for storing an object;
2. The dispensing of the radiopharmaceutical solution according to claim 1, wherein the first container, the second container, the syringe attachment unit, the sensor, and the driving device are stored in the first storage unit. apparatus. Comprising a dispensing device for dispensing to the quality detecting device extracts the radioactive liquid from said first container,
3. The dispensing device for a radiopharmaceutical solution according to claim 2, wherein the distribution device is stored in the first storage unit. The radiation shielding housing has a second storage unit for storing the synthesis device,
Said first container of the first storage unit, and said synthesizing device of the second storage unit connected, characterized in that it comprises the introduction path for guiding the radioactive solution from the synthesizer to the first container The dispensing device for a radioactive chemical solution according to claim 2 or 3.

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