JP4399588B2 - Integrated radiogravimetric and concentration monitor for radiopharmaceuticals - Google Patents

Description

  The present invention relates to the quantitative measurement of radiopharmaceutical concentrations with a short half-life in a substance.

Radiation detectors are used in various fields. Radiation detectors that measure the amount of radiation in a material are important. A positron (positron) is an antiparticle of an electron having a charge opposite to that of the electron, and disappears by colliding with the electron, and annihilates by emitting two gamma rays having energy of 511 keV in the opposite direction. The decaying nuclei that emit positrons are called positron nuclides, and ¹¹ C, ¹⁸ F, ¹³ N, ¹⁵ O, etc. are known. Positron nuclides have a short half-life of about 20 minutes at ¹¹ C and 122 seconds at ¹⁵ O. In inspections and measurements using radionuclides with a short half-life, such as ¹⁵ O, as the labeling compound, ¹⁵ O decays rapidly, so the measurement is time limited. On the other hand, it is used for living body diagnosis in the nuclear medicine field because of the following advantages.
(1) Since these positron nuclides are isotopes of elements constituting molecules existing in the living body, their functions can be observed as labeling agents without modifying the molecules existing in the living body.
(2) Since the half-life is short, there is little exposure to the living body. Therefore, repeated inspection and activation inspection are easy.
(3) Since the half-life is short, the specific activity is high, and diagnosis is possible with a very small amount of nuclide.

^As a diagnostic method by positron emission tomography (PET) using ¹⁵ O ₂ , the following diagnosis has been put into practical use.
Diagnostic purpose: Labeled compound Brain local oxygen metabolism: ¹⁵ O ₂ gas regional blood volume: C ¹⁵ O gas Local blood flow: C ¹⁵ O ₂ gas Local blood flow: H ₂ ¹⁵ O

  In the PET examination, it is necessary to know the blood concentration of the labeled drug administered to the living body. In particular, when quantitatively grasping the behavior (physiological action) of labeled drugs in tissues such as the brain and myocardium, not only changes in the labeled drug concentration in the tissue but also how the labeled drugs Information on whether the tissue has been supplied, that is, measurement of arterial blood concentration is essential. The arterial blood concentration of the labeled drug varies depending on the amount of the labeled drug administered to the living body and the state of the living body. Therefore, the arterial blood concentration of the labeled drug cannot be accurately predicted based on the dose of the labeled drug. In order to accurately grasp the concentration of the labeled drug in the living body, it is necessary to measure the concentration of the labeled drug in the body of the actual subject.

There are two main methods for measuring the concentration of a labeled drug in blood. The first method is a method of continuously collecting blood from an artery through a tube and continuously measuring the concentration of the labeled drug in the tube as the arterial blood concentration. In a PET examination using ¹⁵ O as a labeling agent, it is necessary to measure the arterial blood concentration of the labeling agent with an accuracy of about 1 second, and thus measurement by this method is generally performed. The second method is to measure the blood concentration of the labeled drug using a well-type radiation counter (or gamma counter, hereinafter referred to as well counter) (see, for example, JP-A-11-52061). The well counter measures, for example, the concentration of radiopharmaceuticals in blood as an accessory for examination by a positron emission tomography CT apparatus (PET apparatus) using ¹⁵ O as a labeled compound. The two blood radioactivity concentration measurement methods are appropriately performed in parallel in an actual PET examination.

JP-A-11-52061

In a method of measuring the blood concentration of a labeled drug (such as ¹⁵ O) using a well counter, the collected blood is transferred to a dedicated container and a measurement time of about 10 seconds is required for at least one sample. measure. Furthermore, the mass of the sample is measured each time. In addition, the blood is separated into plasma by a centrifugal separation method, and both the whole blood and plasma may be measured. Since the radioactivity of a radiopharmaceutical has a short half-life, radiation is attenuated between the time when blood is collected and the time when radiation measurement is performed. For this reason, it is necessary to accurately record and correct the time from blood collection to measurement with a stopwatch or the like for all blood collection samples. The work from blood collection to measurement may be performed 10 times or more for one test and 30 times or more depending on the test. For this reason, the time required for the measurement is long and troublesome.

  In addition to the continuous blood radiation measurement device described above, measurement of blood radioactivity concentration (input function) required for conventional PET examinations, well counters, electronic balances for sample weight measurement, and start of examinations Many stopwatches are used to manage time and time from blood collection to measurement of radiopharmaceutical concentration, or footswitches connected to a computer that performs time management, and a panel that displays the progress of the examination to the operator. . Since these apparatuses function separately in the PET inspection, it takes a lot of labor, complexity, and time to proceed the inspection smoothly.

  An object of the present invention is to reduce the work load in measuring the concentration of a radiopharmaceutical having a short half-life in a substance and to facilitate the measurement.

Radiation weighing device according to the present invention is composed of a balance for measuring the weight of an object placed on the pan, and the scintillator of the well-shaped, and photomultiplier tubes for detecting the light of the scintillator, the balance of the dish, cantilevered an arm portion, the arm portion cantilevered insertable into the interior of the scintillator of the well-shaped, and characterized by the Turkey includes a container support portion of the support can be shaped sample containers. Preferably, the radiation weight measuring apparatus further includes a radiation shielding portion disposed outside the scintillator, and the radiation shielding portion includes a through hole through which the cantilever arm portion of the dish of the electronic balance is passed.

  A radiopharmaceutical concentration monitor integrated device according to the present invention is a first signal processing electron that processes a signal from the above-mentioned radiation weight measuring device and a photomultiplier tube of the radiation weight measuring device and discriminates a gamma ray having a specific energy. A circuit, a first measurement control unit that processes, counts and records the signal of the first signal processing electronic circuit, a time recording switch, the radiation weight measuring device, the first signal processing electronic circuit, and the first measurement It consists of a control part and a control part which controls operation of a switch. The control unit records the test start time and the blood sampling time each time a signal is input from the switch at the start of the test and each blood sampling for the same subject, and after the blood sampling time is recorded, the first measurement is performed. When the recording of the blood sample is completed by the control unit, measurement data for the blood sample is input from the first measurement control unit. Preferably, a barcode reader capable of reading a barcode attached to each sample container into which a blood sample is inserted is further provided, and the control unit records the number read by the barcode reader as a sample identification number.

  The radiopharmaceutical concentration monitor integrated device preferably further comprises a blood radiation continuous measurement device for continuously measuring the radiopharmaceutical concentration in the arterial blood of the subject, and a signal processed from the blood radiation continuous measurement device for specific processing. A second signal processing electronic circuit that discriminates gamma rays with energy and processes the signal by a coincidence method; processes and counts the signal of the second signal processing electronic circuit; And a second measurement control unit that records a count value of a signal from a single detector. The control unit controls operations of the blood radiation continuous measurement device, the second signal processing electronic circuit, and the second measurement control unit, and when the continuous measurement of the radiopharmaceutical concentration for the subject is completed, the second measurement is performed. Input measurement data from the controller.

  A measurement management method according to the present invention includes the radiation weight measuring apparatus described above, a first signal processing electronic circuit that processes a signal from a photomultiplier tube of the radiation weight measuring apparatus and discriminates gamma rays having specific energy, A first measurement control unit for processing, counting and recording signals of the first signal processing electronic circuit; a time recording switch; the radiation weight measuring device; the first signal processing electronic circuit; the first measurement control unit; In the radiopharmaceutical concentration monitor integrated device comprising a control unit for controlling the operation of the switch, when a signal is input from the switch at the start of the test for the subject, the test start time is recorded, and each blood sample is collected for the same subject. Sometimes when a signal is input from the above switch, the blood collection time is recorded, the blood collection time is recorded, and then the radiation using the sample container into which the blood sample collected at the blood collection time is inserted When the measurement by the quantity measuring device becomes possible, the measurement is performed in a predetermined time range. When the measurement of the blood sample by the radiation weight measuring device is completed, the measurement data about the blood sample is input from the first measurement control unit. To do. The above processing from recording of blood collection time to input of measurement data is repeated for each blood sample. Preferably, the radiopharmaceutical concentration monitor integrated device further includes a barcode reader capable of reading a barcode attached to each sample container into which a blood sample is inserted, and the number read by the barcode reader is Stored as the identification number of the blood sample.

  The radiopharmaceutical concentration monitor integrated device preferably further comprises a blood radiation continuous measurement device for continuously measuring the radiopharmaceutical concentration in the arterial blood of the subject, and a signal processed from the blood radiation continuous measurement device for specific processing. A second signal processing electronic circuit that discriminates gamma rays with energy and processes the signal by a coincidence method; processes and counts the signal of the second signal processing electronic circuit; And a second measurement control unit that records a count value of a signal from a single detector. Then, before the test start time for the subject, the measurement by the blood radiation continuous measurement device is started, and after the measurement for the last blood sample is completed, the radiopharmaceutical concentration for the subject is continuously measured. The measurement is terminated, and measurement data is input from the second measurement control unit.

Since gravimetry and radiation measurement can be performed simultaneously using a radiation gravimetric apparatus, the concentration and weight of the radiopharmaceutical in the blood sample can be measured under conditions that use a labeled drug with a short half-life, that is, in a limited time. Since it can be measured automatically, the radiation dose in the blood sample can be measured frequently. Thereby, the work load is reduced.
Conventionally, the time is recorded manually (stopwatch) for each blood collection, and the data is corrected manually. For this reason, in the inspection in which the number of samples is more than several tens, it was extremely confusing. However, automatic time management using the blood radiopharmaceutical concentration monitor integrated device greatly reduces the work, eliminates confusion when the number of samples increases, and improves the reliability of the test.
In addition, since the continuous measurement of the concentration of the labeled drug in arterial blood and the measurement of the concentration of the labeled drug for each blood sample can be managed, two types of measurements can be performed in cooperation.

  Hereinafter, embodiments of the present invention will be described with reference to the accompanying drawings. In the drawings, the same reference symbols denote the same or equivalent.

The blood radiopharmaceutical concentration monitor integrated device according to the embodiment of the present invention is used for grasping the blood concentration of a labeled drug administered to a living body in a PET test using a labeled drug containing ¹⁵ O having a short half-life. It is done. In this device, the radiation dose of the labeled drug in the blood can be quantitatively measured in parallel by two methods. In the first method, the arterial blood concentration of the labeled drug in the blood continuously collected from the artery is continuously measured. In the second method, the blood concentration of the labeled drug is measured for each blood sample using a well counter and an electronic balance. Information on the continuous arterial blood concentration (input function) obtained by continuous measurement (first method), and the amount of radioactivity in the collected blood obtained by the well counter and the sample obtained by the electronic balance Collectively manage mass. In the second method, for each sample, the sample is managed by a barcode in order to unify complicated procedures related to the measurement of radioactivity from blood collection and mass measurement of the sample. In addition, using a foot switch, the time management from blood collection to measurement is managed accurately and simply in a batch. Also, the progress of the inspection is displayed on the panel.

  FIG. 1 shows an integrated part for measuring the weight and radiation of a sample (blood sample) in a blood radiopharmaceutical concentration monitor integrated apparatus. An electronic balance 10 for measuring the mass of a sample has the same configuration as that of a normal electronic balance except for a plate 12 on which a sample container is placed. The pan 12 includes a cantilever arm 14 shown on the left side of the drawing, and a cylindrical recess 16 is provided near the end of the arm 14. The concave portion 16 has a cylindrical shape, and accommodates and supports the sample container 18 inserted in the measurement. The amount of radioactivity of the sample 20 in the sample container 18 is measured by a radiation measuring instrument comprising a NaI scintillator 22 and a photomultiplier tube 24. The scintillator 22 has a well shape surrounding the side and bottom of the recess 16. Radiation shielding portions 24 and 26 made of radiation shielding material (lead) are installed on the side and upper portions of the arm 14 and the scintillator 22. Since the radiation shielding parts 24 and 26 form a through hole through which the cantilever arm part 14 of the dish 12 of the electronic balance 10 passes, the radiation shielding parts 24 and 26 do not contact the arm part 14 at the time of weight measurement. These radiation and weight measuring parts are mounted on a common base 28.

One feature of this configuration is that the portion (arm 14) that accommodates the sample (blood collection blood) 20 to be measured for radiation is made a part of the dish of the electronic balance 10 so that the radiation is limited in a limited space. That is, the measuring instrument and the electronic balance 10 for measuring the weight of the sample are integrated. Therefore, when the collected blood is put in the sample container 18 and accommodated in the recess 16, radiation measurement is started and simultaneously the weight of the sample can be measured. That is, under the condition using ¹⁵ O-labeled drug with a short half-life of about 122 seconds, the radiation dose in the sample can be measured frequently by a well counter in a limited short time, and the sample weight measurement can be performed simultaneously. Is possible.

  FIG. 2 shows a part of a blood radiopharmaceutical concentration monitor integrated device. The well counter and the electronic balance shown in FIG. 1 are set on the base of the apparatus main body. A monitor display panel 48 (not shown) and a keyboard 50 are placed on the table. A control device 30 for controlling the entire device is also installed. On the other hand, the blood radiation continuous measuring device 36 (not shown) that continuously measures the arterial blood radiopharmaceutical concentration continuously collects blood from the artery via a tube and measures the amount of radioactivity in the tube. The signal is sent near the subject.

FIG. 3 shows the entire measurement system of the blood radiopharmaceutical concentration monitor integrated apparatus. The signal processing electronic circuit 32 processes the output signal of the photomultiplier tube 24 and discriminates gamma rays having specific energy (511 keV when using ¹⁵ O-labeled drug). The configuration of the signal processing electronic circuit 32 is the same as the conventional one. The first measurement control device 34 is a computer having a CPU (not shown), and processes, counts and records the output signal from the signal processing electronic circuit 30 using a measurement control program, and outputs from the electronic balance 10. Record measurement data. It should be noted that blood sampled blood can be centrifuged using a centrifuge device (not shown).

The blood radiation continuous measuring device 36 continuously measures the arterial blood radiopharmaceutical concentration using two detectors using GSO crystals. The signal processing electronic circuit 38 discriminates gamma rays (511 keV when using a ¹⁵ O-labeled drug) having a specific energy from the signals from the two detectors of the continuous blood radiation measuring device 36, and performs simultaneous counting. Signal processing. The configuration of the signal processing electronic circuit 38 is the same as the conventional one. The second measurement control device 34 is a computer having a CPU, processes and counts output signals from the signal processing electronic circuit 38 using a measurement control program, and counts of individual coincidence counts every second and Record the signal count from a single detector. In this blood radiation continuous measurement, the blood radiation continuous measurement device 36 and the signal processing electronic circuit 38 are installed in the immediate vicinity of the subject, and the output signal from the signal processing electronic circuit 38 is separated from the subject. It is sent to the control device 30 at the position.

  Further, a bar code is attached to the sample container 18 for management of the sample 20. In order to identify the sample in the sample container 18, the barcode is read by the barcode reader 42 when the sample 20 is measured, and the read data is input to the control device 30. Thereby, since the sample 20 can be managed with a barcode, the sample can be easily identified.

  Further, the output signal of the foot switch 44 is input to the control device 30. When the operator steps on the foot switch 44 at the start of the examination, blood collection, etc., the control device 30 records the examination start time, the blood collection time, and the like.

  The measurement using this blood radiopharmaceutical concentration monitor integrated device is performed in parallel with the examination by the positron emission tomography apparatus (PET) 46. For this reason, the control device 30 is also connected to a positron tomography device 46.

  The control device 30 has, for example, a configuration of a personal computer, and includes a display panel 48 for a monitor, a keyboard 50 as an input device, a hard disk device as a mass storage device, and the like in addition to a CPU, ROM, RAM, HDD, and the like. . The control device 30 uses a time management program 52 that performs collective management of each connected unit, and manages these records in an integrated manner to facilitate the progress of the inspection, and displays the progress of the inspection on the display panel 48. . Also, the inspection result is easily calculated.

As shown in the timing chart of FIG. 4, in the blood radiopharmaceutical concentration monitor integrated device, after initial setting of a signal processing electronic circuit or the like, continuous blood collection from the artery of the subject is started, and blood radiation The continuous measurement device 36 is operated. Thereby, the measurement by the blood radiation continuous measuring device 36 is started for blood continuously collected through the tube. Next, a ¹⁵ O-labeled drug is administered to the subject. The foot switch 44 is pushed at the timing of the start of administration, and scanning of the PET measuring device 46 is started and the examination start time is recorded. Thereby, while the imaging of the PET measuring device 46 is continued, the measurement of the continuous blood collection through the tube is simultaneously performed, and the measurement control device 40 processes and counts the signal from the signal processing electronic circuit 38. And every other second, the counts of the individual coincidence counts and the signal counts from a single detector are recorded.

On the other hand, blood is collected sequentially from the subject for measurement of the collected blood, but the foot switch 44 is stepped on each blood collection to record the blood collection time. A part of the collected blood sample is separated into plasma by centrifugation, and then both the whole blood (w) and plasma (p) samples are sequentially placed on the electronic balance 10 to simultaneously measure the weight and radiation dose. . The control circuit 30 receives the output signal from the signal processing electronics 32 and counts the time change of the gamma ray having a specific energy (511 keV when using ¹⁵ O-labeled drug).

  The measurement by the blood radiopharmaceutical concentration monitor integrated device will be further described in detail with reference to FIG. In the figure, the flow of processing for various devices is shown as time advances from top to bottom.

  First, the initial setting described above is performed. In the initial setting, the following processing is performed. In the control device (computer) 30, the examination number and the patient number are registered. Next, the initial weight of a pot (sample container) 18 on which a barcode for inserting a sample liquid to be measured is inserted is measured by the following procedure. First, in order to identify the pot 18, the barcode (sample number) is read by the barcode reader 42, and immediately after that, the weight of the pot 18 is measured by the electronic balance 10. Here, the control device 30 senses that the pot 18 is placed on the barcode reading portion with a sensor (not shown), and reads the barcode number via the barcode reader 42. Next, the pot 18 is within a predetermined time. When the electronic balance 10 is placed on the measurement site, weight measurement is started. When these operations are completed, the measurement time, barcode number (A-1 in the figure) and pot weight (I-1 in the figure) are recorded. The above operation is repeated for the number of samples. Thus, the initial weight of the pot 18 used for measurement is measured. Separately, measurement and recording of the blood labeling drug concentration continuous measuring device 36 is started.

  Next, the inspection will be described. The foot switch 44 is depressed at the start of the inspection, and the time at this time (D-1 in the figure) is recorded. Blood is collected at a predetermined time interval (20 seconds to 1 minute) during the examination, the blood collection time is recorded by pressing a foot switch at the time of collection, and then plasma separation is performed with a centrifuge. Each component of the separated blood is inserted into the pot 18 as a sample, and the sample identification number (bar code) of the pot 18 is read and stored by the barcode reader 42. Next, the pot (sample) is set in a gamma ray detector part (labeled drug concentration measuring device), and weight measurement is started with the electronic balance 10, and radiation dose measurement is started with a gamma ray detector (well counter). If the radiation dose is within a countable range (approximately 20,000 counts or less per second), the switch is pressed and counting is started within a predetermined time range (approximately 10 seconds to 1 minute). When these operations are completed, radiation dose counting start time (D-2 in the figure), identification number by bar code (A-2 in the figure), measured weight (B-2 in the figure), counting time and radiation dose meter Record the numerical value (c in the figure). The above operation is repeated for the number of samples. During this time, the blood labeled drug concentration continuous measurement device 36 continuously measures the radiation dose in the blood that continuously passes through the measurement site, and records the measurement value and time in units of one second.

  When the inspection is completed, the foot switch 44 is depressed at the end of the inspection, and the time at this time is recorded. The computer 30 calculates the labeled drug concentration in the sample in the following procedure. First, referring to the sample identification numbers (a-1 and a-2), the weight (e) of the sample is calculated from the difference in weight before and after the sample measurement (a-1 and i-2). In addition, the radiopharmaceutical attenuation correction count (f) is calculated from the time difference between the radiation dose count start time (D-2 in the figure) and the test start time (D-1) of the sample. The concentration of the labeled drug in the blood is calculated from the radiation dose count value (c in the figure), the weight (v) and the attenuation correction count (f), and the result is recorded and displayed. When the test is completed, the measurement and recording of the blood labeled drug concentration continuous measurement device 36 is terminated.

  FIG. 6 shows a measurement control program of the measurement control device 40. When the measurement start instruction is received after the initial setting (S10), the signal processing electronic circuit 38 starts measurement, and the output data is received and recorded from the signal processing electronic circuit 38 (S12). Then, the obtained data is sent to the control device 30 (S14).

  FIG. 7 shows a measurement control program of the measurement control device 34. When the measurement start instruction is received after the initial setting (S20), the measurement start is reported to the control circuit, the measurement is started by the signal processing electronic circuit 32 and the electronic balance 10, and the measurement is performed from the signal processing electronic circuit 34 and the electronic balance 10. Data is received and recorded (S22). Then, the obtained data is sent to the control device 30 (S24).

  8 and 9 show the time management program 52 executed by the control device 30. FIG. First, the examination number and patient number input by the operator from the keyboard 50 are recorded (S100, S102). Next, when the operator of the pot 18 for putting the sample is put on the electronic balance 10, the initial weight of the pot is measured by the electronic balance 10. First, when the operator operates the barcode reader 42, the barcode attached to the pot 18 is recorded (S104), and then the pot 18 is placed on the electronic balance 10 and the weight value is recorded (S106). ). This is repeated until the measurement is completed for all pots (YES in S108). Moreover, when the measurement start by the blood radiation continuous measuring device 36 is started by the operator, the report is received (S110).

When the operator presses the foot switch 44 at the start of the inspection, a signal is received from the foot switch 44 and recorded as the inspection start time (S112).
Next, blood collection and plasma separation by a centrifuge are performed by the operator. The operator presses the foot switch 44 during blood collection. Thus, a signal is received from the foot switch 44 and recorded as a blood collection time (S114). When the operator operates the barcode reader 42 for sample identification, the barcode attached to the pot 18 is read and recorded as a sample identification number (S116). Next, when the sample placed in the pot 18 by the operator is positioned on the well counter, the weight measurement and the radiation count are performed simultaneously. When the measurement for a predetermined time is completed, the measured weight, the counting time, and the radiation dose count value are input and recorded (S118). The above operation is repeated until the measurement of all samples is completed (S120).

  When the operator presses the foot switch 44 at the end of the inspection, a signal is received from the foot switch 44 and recorded as the inspection end time (S122). When the operator instructs the end of measurement by the continuous blood radiation measuring device 36, the report is received (S124). Next, the above-described various data processing is performed based on the measurement data (S126).

  In the above-described example, the control device 30 and the measurement control devices 34 and 40 are configured as separate computers. However, measurement control and time management can be combined in various forms.

  In the above-described example, the continuous measurement of the concentration of the labeled drug in arterial blood and the measurement of the concentration of the labeled drug for each blood sample are performed in parallel. However, the above-described blood radiopharmaceutical concentration monitor integrated device can perform only one of the measurements.

  Although not specifically described, the progress of the above-described inspection is displayed on the display panel 48. Coordination with the display panel makes it easier for staff involved in inspections to unify their intentions.

  By using a radiation gravimetric measuring device in which the electronic balance 10, the scintillator 22 and the photomultiplier tube 24 are integrated as described above, the concentration of the radiopharmaceutical in a blood sample having a short half-life in the substance and its concentration The weight could be measured automatically.

  In addition, before the above-mentioned blood radiopharmaceutical concentration monitor integrated device was completed, the time was recorded manually (stopwatch) for each blood collection and corrected by manual calculation. For this reason, in the inspection in which the number of samples is more than several tens, it was extremely confusing. However, the automatic time management based on the development of this device has greatly reduced the work, eliminated confusion when the number of samples increased, and improved the reliability of the inspection. For example, the cross calibration factor (CCF) can be calculated automatically and the data can be corrected during the measurement.

  In addition, since the continuous measurement of the concentration of the labeled drug in arterial blood and the measurement of the concentration of the labeled drug for each blood sample can be managed, two types of measurements can be performed in cooperation.

  In addition, automatic input control and optimal administration became possible by performing real-time evaluation of arterial blood concentration in conjunction with an automatic administration device for radiopharmaceuticals.

  In addition, a dedicated engineer is no longer needed due to the simplified and fully automated testing.

Part of the radiopharmaceutical concentration measurement device The figure which shows the whole radiopharmaceutical concentration measuring device Block diagram showing outline of measurement system of radiopharmaceutical concentration measuring device Measurement timing chart Timing chart summarized on different aspects of measurement Measurement control flowchart Measurement control flowchart Flow chart of part of time management Flow chart for the rest of time management

Explanation of symbols

DESCRIPTION OF SYMBOLS 10 Electronic balance, 12 dishes, 14 Cantilever arm 14, 16 Recessed part, 18 Sample container, 20 Sample, 22 Scintillator, 24 Photomultiplier tube, 24, 26 Radiation shielding part, 30 Control apparatus, 32 1st signal processing electronic circuit 34 First measurement control device, 36 Blood radiation continuous measurement device, 38 Second signal processing electronic circuit, 40 Second measurement control device, 42 Bar code reader, 44 Foot switch, 46 Positron tomography examination device, 48 Display panel 52 hours management program.

Claims (8)

A balance for measuring the weight of an object placed on a plate;
A well-shaped scintillator;
It consists of a photomultiplier tube that detects the light of the scintillator,
Balance pan is provided with an arm portion cantilevered, arm portions cantilevered insertable into the interior of the scintillator of the well-shaped, and the features and Turkey provided with a container support portion of the support can be shaped sample containers Radiation weight measuring device.   The radiation weighing unit according to claim 1, further comprising a radiation shielding unit disposed outside the scintillator, wherein the radiation shielding unit includes a through hole through which the cantilever arm portion of the dish of the electronic balance passes. apparatus. Radiation weight measuring device according to claim 1 or 2,
A first signal processing electronic circuit for processing a signal from a photomultiplier tube of a radiation gravimetric apparatus and discriminating gamma rays having a specific energy;
A first measurement controller for processing, counting and recording signals of the first signal processing electronics;
A time recording switch,
The radiation weight measuring device, the first signal processing electronic circuit, the first measurement control unit, and a control unit for controlling the operation of the switch,
The control unit records the test start time and the blood sampling time each time a signal is input from the switch at the start of the test and each blood sampling for the same subject, and after the blood sampling time is recorded, the first measurement is performed. A radiopharmaceutical concentration monitor integrated device that inputs measurement data about a blood sample from the first measurement control unit when the control unit finishes recording the blood sample.   Furthermore, a barcode reader capable of reading the barcode attached to each sample container into which the blood sample is inserted is provided, and the control unit records the number read by the barcode reader as a sample identification number. The radiopharmaceutical concentration monitor integrated device according to claim 3. further,
A continuous blood radiation measuring device for continuously measuring the concentration of a radiopharmaceutical in arterial blood of a subject;
A second signal processing electronic circuit that processes a signal from a continuous blood radiation measuring device, discriminates a gamma ray having a specific energy, and performs signal processing by a coincidence method;
A second measurement control unit that processes and counts the signal of the second signal processing electronic circuit and records the count value of each simultaneous count and the count value of the signal from a single detector every second;
The control unit controls operations of the blood radiation continuous measurement device, the second signal processing electronic circuit, and the second measurement control unit, and when the continuous measurement of the radiopharmaceutical concentration for the subject is completed, the second measurement is performed. The radiopharmaceutical concentration monitor integrated device according to claim 3 or 4, wherein measurement data is input from the control unit. Radiation weight measuring device according to claim 1 or 2,
A first signal processing electronic circuit for processing a signal from a photomultiplier tube of a radiation gravimetric apparatus and discriminating gamma rays having a specific energy;
A first measurement controller for processing, counting and recording signals of the first signal processing electronics;
A time recording switch,
In the radiopharmaceutical concentration monitor integrated device comprising the radiation weight measuring device, the first signal processing electronic circuit, the first measurement control unit, and the control unit for controlling the operation of the switch,
When a signal is input from the above switch at the start of the test for the subject, the test start time is recorded,
When a signal is input from the above switch during each blood collection for the same subject, the blood collection time is recorded,
After recording the blood collection time, when measurement by a radiation weight measuring device using a sample container into which a blood sample collected at the blood collection time is possible, measurement is performed in a predetermined time range,
When the measurement of the blood sample by the radiation weight measuring apparatus is completed, the measurement data about the blood sample is input from the first measurement control unit,
A measurement management method in which the processing from the recording of the blood sampling time to the input of measurement data is repeated for each blood sample. The radiopharmaceutical concentration monitor integrated device further includes a barcode reader capable of reading the barcode attached to each sample container into which the blood sample is inserted.
The measurement management method according to claim 6, wherein a number read by a barcode reader is stored as an identification number of the blood sample. Radiopharmaceutical concentration monitor integrated device
A continuous blood radiation measuring device for continuously measuring the concentration of a radiopharmaceutical in arterial blood of a subject;
A second signal processing electronic circuit that processes a signal from a continuous blood radiation measuring device, discriminates a gamma ray having a specific energy, and performs signal processing by a coincidence method;
A second measurement control unit that processes and counts the signal of the second signal processing electronic circuit and records the count value of each simultaneous count and the count value of the signal from a single detector every second;
Prior to the test start time for the subject, measurement by the continuous blood radiation measuring device is started, and after the measurement for the last blood sample is completed, the radiopharmaceutical concentration for the subject is continuously measured. The measurement management method according to claim 6, wherein measurement data is input from the second measurement control unit.

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