JP4740676B2 - Drug discharging device, medical multi-chamber container equipped with the same, and method for manufacturing the same - Google Patents

Description

  The present invention relates to a medical multi-chamber container provided with a plurality of storage chambers that individually store various unstable drugs (solutions, powders, or solid agents) that change with time when mixed simultaneously.

  Among drugs such as ophthalmic perfusate and peritoneal dialysis fluid that are administered to a patient by intravenous injection, there are unstable drugs that cause undesirable changes over time when pre-mixed. For example, when an amino acid infusion solution and a glucose infusion solution are blended and stored, the mixed solution browns by a so-called Maillard reaction. In addition, if fat emulsion and electrolyte solution are blended and stored, the fat will aggregate, and if phosphoric acid-containing liquid and calcium-containing liquid are blended, calcium phosphate will precipitate and undesirable changes will occur. Wake up.

  The following medical multi-chamber containers are often used for such drugs. The medical multi-chamber container includes a plastic film container main body having two storage chambers for storing medicines, and a medicine discharge portion for discharging the medicines from the container main body. The two storage chambers are partitioned by a partition sealing portion in which the inner wall surfaces of the container body are heat-sealed. In use, the vicinity of the center of one of the storage chambers is pressed to increase the pressure in the storage chamber to open the partition sealing portion. As a result, the two storage chambers communicate with each other and the two drugs are mixed. Thereafter, the medicine discharge part is opened by insertion or the like, and the mixed medicine is administered to the patient.

By the way, in the multi-chamber container as described above, there is a problem that the medicine before mixing is discharged when the discharge part is opened before the partition sealing part is opened. In order to solve this problem, for example, Patent Document 1 proposes a medical container in which a discharge restricting sealing portion is provided between a medicine discharging portion and a storage chamber adjacent thereto. This discharge restricting sealing portion is formed by heat-sealing the inner wall surfaces of the container main body in the same manner as the partition sealing portion, and its opening strength is equivalent to that of the partition sealing portion or More than that. Providing this discharge regulation sealing part prevents the medicine from being discharged from the storage chamber by the discharge regulation sealing part even if the medicine discharge part is opened before the partition sealing part is opened. Can do.
JP-A-9-327498

  However, since the medical multi-chamber container described in Patent Document 1 has the following problems, it has not been widely spread. That is, the vicinity of the discharge part in the container body is not flattened due to the film rising. Therefore, when the discharge restricting sealing portion is formed by heat fusion, there is a problem that wrinkles and pinholes are likely to occur. Due to this, the variation in the heat-sealing strength of the discharge restricting sealing portion increases, and it is not easy to adjust the opening strength of both sealing portions. In addition, a space is formed between the medicine discharge part and the discharge regulation sealing part, but since this medicine does not contain the medicine, sterilization in this space is guaranteed even if heat sterilization is performed. There is also a problem that it cannot be done.

  The present invention has been made to solve the above-described problems, and is a drug discharger capable of easily preventing discharge of a drug before mixing, a medical multi-chamber container provided with the same, and a An object is to provide a manufacturing method.

  The present invention is a medical multiple chamber provided with a container body having a plurality of storage chambers for storing a medicine and a partition sealing portion for partitioning each of the storage chambers, wherein the partition sealing portion is opened for use. A drug discharger attached to a container and capable of discharging a drug in the container main body, formed in a tubular shape, one end of which can be attached to any storage chamber, and the other end of the main body A sealing member that seals the portion side and can be opened in use, and a regulating member that seals one end of the main body and regulates the inflow of the medicine from the storage chamber, It protrudes from one end of the main body, and the restriction state is released when the restriction member enters the main body by a predetermined force, so that the medicine can flow into the main body from the storage chamber. It is configured.

  According to this configuration, since the communication between the storage chamber and the medicine discharger is restricted by the restriction member, for example, before opening the partition sealing portion, the puncture needle is inserted into the sealing member by mistake. Even in this case, the medicine before mixing in the storage chamber is prevented from being discharged from the discharge tool.

  Further, since the restricting member protrudes from the main body portion toward the storage chamber, the restricting member can be pushed in by hand. For example, when the storage chamber is pressed but the regulating member cannot be moved by the pressure, the regulated state of the medicine inflow can be forcibly released, which is effective. Moreover, since it can push in by hand, the delicate adjustment of the force for regulation cancellation becomes unnecessary, and a manufacturing process can be simplified.

  In addition, although the main body mentioned above is formed in the tubular shape, the cross-sectional shape is not specifically limited, For example other than circular cross section, it can be set as rectangular shape, polygonal shape, etc.

  The main body described above can have various forms. For example, the main body has a small-diameter portion that is attached to the storage chamber and a large-diameter portion that is connected to the small-diameter portion, and the regulating member is the storage chamber. A restricted state can be formed by being press-fitted into the small diameter portion so as to protrude to the side, and the restricted state can be released by moving to the large diameter portion with a predetermined force.

  It is preferable that the regulating member is formed in a cylindrical shape and has a target shape with respect to an intermediate point in the axial direction. In addition, this control member can be made into a rectangular shape, a polygonal shape, etc. according to the cross-sectional shape of a main body, when the main body mentioned above is formed in cross sections other than circular.

  Further, the regulating member can be colored in a color different from that of the main body. By doing so, it becomes easy to visually recognize the regulating member.

  The medical multi-chamber container according to the present invention includes a plurality of storage chambers for storing a drug, a container main body having a partition sealing portion for partitioning each of the storage chambers, and the above-described drug discharger attached to the container main body. The partition sealing portion is configured to be openable so as to allow the storage chambers to communicate with each other during use, and the predetermined force is greater than the opening strength of the partition sealing portion. It is configured.

  According to this configuration, the above-described effect of the medicine discharge tool can be obtained, and when the storage chamber to which the medicine discharge tool is attached is pressed, the partition sealing portion can be opened first. Therefore, it is possible to prevent the restriction state from being released before the partition sealing portion is opened, and it is possible to prevent the medicine before mixing from being discharged. The “opening strength” refers to a force required to open even a part of the partition sealing portion and connect adjacent storage chambers.

  A first method for producing a medical multi-chamber container according to the present invention comprises a step of preparing a container body capable of storing a medicine and having a medicine inlet formed in a part of a peripheral edge, and the medicine inlet. A step of injecting the first medicine into the container body, and dividing the internal space of the container body into two above the liquid surface of the first medicine, so that the first medicine is stored. A step of providing a partition sealing portion forming a second storage chamber communicating with the first storage chamber and the drug injection port; and a step of injecting a second drug into the second storage chamber via the drug injection port And a step of inserting the above-described medicine discharge tool into the medicine injection port and fixing the main body portion to the peripheral edge portion in a state where the regulating member protrudes into the second storage chamber.

  Moreover, the second method for producing a medical multi-chamber container according to the present invention includes a step of preparing a tubular main body portion having a small diameter portion and a large diameter portion, a step of preparing a container main body capable of storing a medicine, Attaching the main body to the container main body with the small diameter portion facing the container main body, injecting a first drug into the container main body via the main body, and the first A partition seal that divides the internal space of the container main body into two above the liquid surface of the medicine, and forms a first storage chamber in which the first medicine is stored and a second storage chamber in communication with the main body. A step of providing a stopper, a step of injecting a second medicine into the second storage chamber via the main body, and a regulation for restricting communication between the large diameter portion and the second storage chamber in the small diameter portion Press-fitting a member, and projecting the regulating member from the small diameter portion to the second storage chamber; And a step of sealing by the sealing member and the other end side of the main body portion.

  It is preferable that the restricting member is configured to move to the large diameter portion side and release the restricted state when the pressure in the storage chamber increases.

  Moreover, it is preferable that the force required to move the regulating member to release the regulated state of the inflow of medicine is larger than the opening strength of the partition sealing portion.

  According to the medicine discharge tool, the medical multi-chamber container and the manufacturing method thereof according to the present invention, it is possible to reliably prevent the medicine before mixing from flowing out from the discharge portion.

  Hereinafter, an embodiment of a medical multi-chamber container according to the present invention will be described with reference to the drawings. FIG. 1 is a plan view of the medical multi-chamber container according to the first embodiment, and FIG. 2 is a cross-sectional view of a principal part showing a medicine discharge tool in the medical multi-chamber container of FIG.

  As shown in FIG. 1, the medical multi-chamber container 1 includes a container main body 3 having a peripheral portion 2 fused and formed in a rectangular shape, and a drug discharger 32 attached to the container main body 3 for discharging a drug. It has. The container body 3 includes a first storage chamber 10 and a second storage chamber 11 arranged side by side in the longitudinal direction, and the two storage chambers 10 and 11 are partitioned by a partition sealing portion 20. The medicine discharge tool 32 described above is fused to the peripheral edge 2 of the container body and attached so that one end thereof enters the second storage chamber 11. Further, a hanging hole 30 is formed on the container body peripheral edge 2 on the first storage chamber 10 side. Each of the storage chambers 10 and 11 stores various drugs a and b which are not desirable when mixed or dissolved in advance. For example, amino acid infusion and glucose infusion are stored. Note that a solid or powdered medicine can be stored in one storage chamber.

  The medical multi-chamber container 1 can be a bag-like container formed by heat-sealing or bonding the peripheral portions of two flat layers or multi-layer films. As the material of the film, various resins such as thermoplastic resins such as polyethylene, polypropylene, and polystyrene can be employed.

  Alternatively, if at least the innermost layer of the film constituting the container body 3 is composed of two or more thermoplastics having poor compatibility and different melting points, the partition sealing portion 20 can be easily formed as described later. Can be formed. Examples of such plastics include those obtained by mixing a resin selected from styrene-based resins, methacrylic ester-based resins, poly-4-methylpentene, polyester, polyamide, and polypropylene with polyethylene. Among these, polyethylene and polypropylene are particularly preferable since safety is confirmed for medical use and a handling method in production is established. The mixing ratio of the two is not particularly limited, but is generally selected from the range of 1: 9 to 9: 1.

  The partition sealing portion 20 can be configured to be openable in various modes. For example, the partition sealing portion 20 can be configured by adhering opposing film surfaces of the container body 3 by heat fusion. The partition sealing portion 20 is configured to be opened when the pressure in the storage chambers 10 and 11 increases to reach a predetermined pressure, and the storage chambers 10 and 11 communicate with each other.

  As shown in FIG. 2A, the medicine discharge tool 32 includes a main body portion 36 formed in a circular tube shape, and the main body portion 36 is provided with one end side (upper side in FIG. 2) from the second storage chamber 11. A regulating member 37 that regulates the inflow of medicine is attached. On the other hand, the other end of the main body 36 is sealed with a rubber plug (sealing member) 39 that can be opened with a piercing needle.

  The main body portion 36 is configured by connecting a small diameter portion 41 and a large diameter portion 43, and the small diameter portion 41 is disposed on the storage chamber 11 side. The restricting member 37 is formed in a cylindrical shape, and the diameter of the intermediate portion 37a in the axial direction is larger than both end portions. That is, the shape is a target with respect to the axial intermediate point. Further, the outer diameter of the intermediate portion 37a is slightly larger than the inner diameter of the small diameter portion 41. In the initial state, as shown in FIG. 2A, the regulating member 37 is press-fitted into the small diameter portion 41, and the intermediate portion 37 a is engaged with the inner wall surface of the small diameter portion 41. As a result, one end of the main body 36 is sealed in a liquid-tight state by the regulating member 37, and the inflow of the medicine from the second storage chamber 11 into the main body 36 is restricted. At this time, one end portion of the restricting member 37 protrudes from the small diameter portion 41 to the storage chamber 11.

  The large diameter portion 43 has an inner diameter larger than that of the regulating member 37, and the opening end portion thereof is sealed with a rubber plug 39. Then, as will be described later, when the restricting member 37 moves and the engagement with the small-diameter portion 41 is released, it is accommodated in the large-diameter portion 43 as shown in FIG. The restricting member 37 is configured such that the engagement state with the small diameter portion 41 is released when the protruding portion enters the small diameter portion 41. Here, the regulating member 37 and the large diameter portion 43 are sized so as not to hinder the flow of the medicine from the small diameter portion 41 toward the rubber plug 39 when the regulating member 37 is accommodated in the large diameter portion 43. Has been.

  The force for moving the restricting member 37 to release the engagement state between the restricting member 37 and the small diameter portion 41 is greater than the opening strength necessary for opening the partition sealing portion 20. The opening strength referred to here is a force necessary to open a part of the partition sealing portion 20 and to allow the storage chambers 10 and 11 partitioned by the partition sealing portion 20 to communicate with each other. .

  Next, the usage method of the medical multi-chamber container comprised as mentioned above is demonstrated. In order to administer the drug in the container 1 to the patient, first, the second storage chamber 11 in which the liquid drug b is stored is pressed by hand or the like to increase the pressure in the storage chamber 11. Thereby, the sealing part 20 for partitions opens, the 1st and 2nd storage chambers 10 and 11 are connected, and the chemical | medical agents a and b in each storage chamber 10 and 11 are mixed. As described above, since the opening strength of the partition sealing portion 20 is smaller than the force for releasing the engagement state between the regulating member 37 and the small diameter portion 41, even if the partition sealing portion 20 is opened. The engagement state between the regulating member 37 and the small diameter portion 41 is not released, and the medicine does not flow into the main body portion.

  Subsequently, the entire first and second storage chambers 10 and 11 communicated are pressed to increase the pressure, and the regulating member 37 is moved. That is, when the pressure in the storage chambers 10 and 11 is increased, the regulating member 37 is pressed by the mixed medicine and moved to the large diameter portion 43 side. Thus, when the regulating member 37 enters the large diameter portion 43, the sealed state of the small diameter portion 41 is released, so that the second storage chamber 11 and the large diameter portion 43 communicate with each other, and the mixed medicine is in the small diameter portion 41. Flows into the main body 36 from the opening. Thereafter, when the puncture needle connected to the conduit is inserted into the rubber stopper 39, the mixed medicine in the container 1 is administered from the medicine discharge tool 32 to the patient through the conduit.

  If the restricting member 37 does not move when the storage chambers 10 and 11 are pressed, the restricting member 37 is pushed into the main body portion 36 by hand to release the engagement state with the small diameter portion 41. As shown in FIG. 1, since the regulating member 37 protrudes from the main body portion 36 toward the second storage chamber 11, the regulating member 37 can be pushed from above the film constituting the container body 3. At this time, since the film is soft, the pressing operation of the regulating member 37 is not hindered.

  As described above, according to the present embodiment, since the communication between the second storage chamber 11 and the medicine discharge tool 32 is restricted by the restriction member 37, for example, before the partition sealing portion 20 is opened, an error may occur. Thus, even when a puncture needle is inserted into the rubber plug 39, the medicine before mixing in the second storage chamber 11 is prevented from being discharged from the discharge tool 32. In this case, since the medicine is not discharged from the medicine discharge tool 32 even if the puncture needle is inserted, the user does not push in the regulating member 37 and the partition sealing portion 20 is opened. Can recognize that not. Therefore, by providing such a regulating member 37 in the medicine discharge tool 32, it is possible to insert a puncture needle properly after an appropriate usage method, that is, after opening the partition sealing portion 20 and pushing the regulating member 37. Can be used in order.

  Further, if the regulation member 37 as described above is provided in the medicine discharge tool 32, a mechanism for regulating the discharge of the medicine before mixing as in the conventional example may not be provided on the container body 3 side. Therefore, if such a medicine discharge tool 32 is prepared and attached to the container body 3, the manufacturing equipment for the multi-chamber container 1 can be simplified and the manufacturing time can be shortened.

  Furthermore, since the regulating member 37 protrudes from the main body portion 36 toward the second storage chamber 11 side, when the regulating member 37 does not move when the storage chambers 10 and 11 are pressed, the regulating member 37 is pushed in by hand. be able to. Therefore, there are the following advantages. That is, the regulating member 37 and the small diameter portion 41 are adjusted so that the engagement state is released when the pressure in the storage chambers 10 and 11 is increased and a force larger than the opening strength of the partition sealing portion 20 is applied. However, if the restricting member 37 does not move, the engaged state can be released by pushing it in by hand. Therefore, when press-fitting the regulating member 37 at the time of manufacture, it is not always necessary to make an accurate adjustment as described above. Therefore, the manufacture of the multi-chamber container can be facilitated.

  Further, since the restricting member 37 has a target shape with respect to the intermediate point in the axial direction, the same effect can be obtained even if it is inserted into the main body 36 from any end in the axial direction. The regulating member 37 can also be colored in a color different from that of the main body portion 36. By doing so, the regulating member 37 can be easily seen and the operation efficiency is improved.

  Next, an example of a method for manufacturing the multi-chamber container will be described with reference to FIG. First, the container body 3 is formed by strongly heat-sealing the peripheral edges of the two films (FIG. 3A). At this time, a medicine injection port 2a for injecting medicine at one end of the peripheral edge 2 is formed. Next, one drug (first drug) is injected into the container body 3 through the drug injection port 2a (FIG. 3B). This medicine accumulates at a position where the first storage chamber 10 on the side opposite to the medicine injection port 2a is formed. Subsequently, in the middle part of the container main body 3, that is, above the liquid level of the previously injected medicine, the films are heat-sealed to form the partition sealing part 20 (FIG. 3C). As a result, the first storage chamber 10 and the second storage chamber 11 are formed in the container body 3, and the medicine previously injected is sealed in the first storage chamber 10.

  Then, another drug (second drug) is injected into the second storage chamber through the drug injection port 2a (FIG. 3D). Following this, after inserting the above-described drug discharge tool into the drug injection port 2a, the film and the drug discharge tool 32 are heat-sealed to fix the drug discharge tool 32 to the peripheral edge 2 (FIG. 3 (e)). . Thus, the multi-chamber container is completed.

  It can also be formed by the following method. As shown in FIG. 4, first, the peripheral edge of the film is strongly heat-sealed in a state where the main body portion 36 of the medicine discharge tool 32 is sandwiched between the two films. Thereby, while the container main body peripheral part 2 is formed, the main-body part 36 is connected with the container main body 3 (FIG. 4 (a)). Next, one chemical | medical agent is inject | poured in the container main body 3 through the main-body part 36 (FIG.4 (b)). Subsequently, in the middle part of the container main body 3, that is, above the liquid level of the previously injected medicine, the films are thermally fused to form the partition sealing part 20 (FIG. 4C). As a result, the first storage chamber 10 and the second storage chamber 11 are formed in the container body 3, and the medicine previously injected is sealed in the first storage chamber 10.

  And another chemical | medical agent is inject | poured into a 2nd storage chamber through the main-body part 36 (FIG.4 (d)). Subsequently, the restricting member 37 is inserted from the large diameter portion 43 of the main body portion 36, and press-fitted into the small diameter portion 43 until the end portion of the restricting member 37 protrudes from the main body portion 36 (FIG. 4E). Finally, when the rubber stopper 39 is attached to the large diameter portion 43, the multi-chamber container is completed.

  In any of the above-described methods, it is not always necessary to accurately adjust the force when the restricting member 37 is press-fitted. Therefore, since it is not necessary to adjust the delicate force, the manufacture of the multi-chamber container can be facilitated.

  As mentioned above, although one Embodiment of this invention was described, this invention is not limited to the said embodiment, A various change is possible unless it deviates from the meaning. For example, in the above embodiment, the main body portion 36 is configured by connecting the small diameter portion 41 and the large diameter portion 43, and the connection portion has a stepped portion, but the present invention is not limited to this. The storage chambers 10 and 11 and the main body 36 may be configured to communicate with each other when the restriction member 37 is pushed in from the restriction state where the medicine flows. For example, the main body 36 can be configured to gradually increase in inner diameter as it goes from the storage chamber side to the rubber plug side. In addition, the regulating member 37 is not necessarily limited to a target shape in the axial direction, and is not limited as long as it can be press-fitted into the small-diameter portion 41 of the main body portion 36. For example, it can be formed in a prismatic shape, and the main body 36 can be shaped to correspond to this.

  In the above embodiment, the pressure for moving the regulating member 37 is set to be larger than the pressure for opening the partition sealing portion 20, but the pressure for opening the partition sealing portion is The restricting member 37 can also be configured to move with equal pressure.

  Moreover, in each said embodiment, although the other end part of the chemical | medical agent discharge tool 32 is sealed with the rubber stopper 39, if it can open in use, it will not specifically limit.

  Moreover, in the medical multi-chamber container of each said embodiment, although it is comprised so that two types of chemical | medical agents can be mixed, it is not limited to this, It can also be made to provide three or more storage chambers. .

  In the container body of the above embodiment, the partition sealing portion of the present invention is configured as a sealing portion by fusing the film surface, but is not limited to this, and when a predetermined external force is applied What is necessary is just to be comprised so that it may open. For example, the partition sealing portion can also be configured by concave-convex fitting between a ridge and a concave provided on the film surface.

  Moreover, in the said embodiment, although the chemical | medical agent discharge tool 32 is attached to the container main body peripheral part 2 by heat fusion, depending on the material which comprises the container main body 3, methods, such as high frequency welding and ultrasonic sealing, should be used. You can also. Even in other methods, the connection method is not particularly limited as long as the storage chamber 11 of the container body 3 and the medicine discharge tool 32 are connected in a liquid-tight state.

It is a top view of one embodiment of a medical multi-chamber container according to the present invention. It is principal part sectional drawing of the chemical | medical agent discharge tool which concerns on the medical multiple chamber container of FIG. It is a figure which shows an example of the manufacturing method of the medical multiple-chamber container of FIG. It is a figure which shows the other example of the manufacturing method of the medical multiple chamber container of FIG.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Medical multiple-chamber container 3 Container main body 10,11 Storage chamber 20 Partition sealing part 32 Drug discharge tool 36 Main body part 37 Restriction member 39 Rubber stopper (sealing member)
41 Small diameter part 43 Large diameter part

Claims (10)

A container body having a plurality of storage chambers for storing medicines and a partition sealing portion for partitioning the storage chambers is attached to a medical multi-chamber container in which the partition sealing portion is opened in use. , A drug discharger capable of discharging the drug in the container body,
A main body part that is formed in a tubular shape and can be attached to one of the storage chambers at one end thereof;
A sealing member that seals the other end of the main body and can be opened for use;
A sealing member that seals one end of the main body and regulates the inflow of medicine from the storage chamber,
The restricting member protrudes from one end of the main body so that it can be pushed by hand from the outside of the container main body,
A medicine discharge tool that allows the inflow of medicine from a storage chamber into the main body when the restriction member enters the main body by the force of the hand and the restriction state of the inflow of medicine is released. The main body portion has a small diameter portion attached to the storage chamber, and a large diameter portion connected to the small diameter portion,
The restricting member forms the restricting state by being press-fitted into the small diameter portion so as to protrude toward the storage chamber, and the restricting state is released by moving to the large diameter portion by the force of the hand. The medicine discharge tool according to claim 1.   The medicine discharge tool according to claim 1 or 2, wherein the restricting member is formed in a cylindrical shape and has a shape that is a target at an intermediate point in the axial direction.   The medicine discharge tool according to any one of claims 1 to 3, wherein the regulating member is colored in a color different from that of the main body. A plurality of storage chambers for storing medicines, and a container body having a partition sealing portion for partitioning each of the storage chambers;
The drug discharger according to any one of claims 1 to 4, which is attached to the container body,
The multi-chamber container for medical use, wherein the partition sealing portion is configured to be openable so that the storage chambers communicate with each other in use. A step of preparing a container body capable of storing a medicine and having a medicine inlet formed in a part of the peripheral edge;
Injecting a first drug into the container body through the drug injection port;
Above the liquid surface of the first drug, an internal space of the container body is divided into two, a first storage chamber in which the first drug is stored, and a second storage chamber in communication with the drug injection port. Providing a partition sealing portion to be formed;
Injecting a second drug into the second storage chamber via the drug injection port;
Inserting the medicine discharge tool according to any one of claims 1 to 4 into the medicine injection port, and fixing the main body to the peripheral edge in a state where the regulating member protrudes into the second storage chamber. A method for producing a medical multi-chamber container. Preparing a tubular main body portion having a small diameter portion and a large diameter portion;
Preparing a container body capable of storing a medicine;
Attaching the main body to the container main body with the small diameter portion facing the container main body;
Injecting a first drug into the container body via the body part;
Above the liquid surface of the first drug, the internal space of the container main body is divided into two, and a first storage chamber for storing the first drug and a second storage chamber communicating with the main body portion are formed. Providing a partition sealing portion to be performed;
Injecting a second drug into the second storage chamber via the main body;
A step of press-fitting a regulating member that regulates communication between the large-diameter portion and the second storage chamber into the small-diameter portion, and projecting the regulating member from the small-diameter portion to the second storage chamber;
Sealing the other end of the main body with a sealing member,
After the partition sealing portion is opened , the restricting member is manually pushed from the outside of the container body to release the engagement state with the small diameter portion, and the partition sealing portion is opened. A method of manufacturing a medical multi-chamber container configured to allow a drug to flow into the main body from the container main body . The regulating member, by the pressure in the container body to the partitioning seal portion is opened is increased, to release the restricted state of the drug inflow moves to the other end of the body portion, according to claim 6 Manufacturing method for medical multi-chamber containers. The medical device according to claim 7 , wherein the regulating member moves toward the large-diameter portion and releases the regulated state of medicine inflow by increasing the pressure in the container main body in which the partition sealing portion is opened. Of manufacturing a multi-chamber container. The method for producing a medical multi-chamber container according to claim 8 or 9 , wherein a force required to move the regulating member to release the regulated state is larger than an opening strength of the partition sealing portion. .

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