JP2007307414A - Discharge method of medical agent - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a medical agent discharge member and a medical dual-chamber container surely preventing the outflow of medical agents before mixture from a discharge section. <P>SOLUTION: A medical agent discharge member is attached to the medical dual-chamber container having a container body provided with a plurality of storage chambers for storing medical agents and a partitioning weak seal portion partitioning the storage chambers and constituted to be opened in use, and can discharge the medical agents in the container body. The medical agent discharge member has the body part formed into a tubular shape and having its one end attachable to either of the storage chambers, a sealing member sealing the other end side of the body part and being opened in the use, and a medical agent discharge mechanism sealing one end side of the body part and restricting the inflow of the medical agent from the storage chamber. When a prescribed pressure is applied from the storage chamber, the medical agent discharge mechanism releases the sealing state and allows the inflow of the medical agents from the container body to the body part inside. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention provides a plurality of storage chambers that individually store various unstable drugs (liquid, powder, or solid agent) that change with time when mixed simultaneously, and a container main body having a sealing part for partitioning each storage chamber And a medicine discharge method that is attached to the container body and discharges the medicine.

  Among drugs administered to patients by intravenous injection, there are unstable drugs that cause undesirable changes over time when pre-mixed. For example, when an amino acid infusion solution and a glucose infusion solution are blended and stored, the mixed solution browns by a so-called Maillard reaction. In addition, if fat emulsion and electrolyte solution are blended and stored, the fat will aggregate, and if phosphoric acid-containing liquid and calcium-containing liquid are blended, calcium phosphate will precipitate and undesirable changes will occur. Wake up.

  For such drugs, medical multi-chamber containers that individually store components before mixing are often used. This medical multi-chamber container includes a plurality of storage chambers for individually storing medicines, and a partition weak seal portion that can be opened by partitioning each storage chamber by applying pressure from the outside.

  FIG. 10 is a plan view showing an example of such a conventional medical multi-chamber container, and FIG. 11 is a sectional view taken along line XX of FIG.

  In each of the storage chambers 10 and 11 of the medical multi-chamber container, various drugs a and b which are undesirable when mixed or dissolved in advance are stored, respectively, and these drugs a and b are isolated by the weak seal portion 20 for partitioning. It is stored safely and reliably in the used state until it is used. When the storage chamber 10 or 11 is pressed in use, the pressure in the storage chamber increases and the partition weak seal portion 20 is opened. Thereby, the inside of both the storage chambers 10 and 11 will be in a communication state, and both chemical | medical agents a and b will be mixed or melt | dissolved rapidly.

  Further, the medical multi-chamber container 1 includes a hanging hole 30 at one end and a drug discharge member 32 having a rubber stopper at the other end. When administering a mixed medicine to a patient, the container is suspended from a support column or the like through the hanging hole 30 and then a piercing needle provided with a conduit is inserted into the rubber stopper of the discharge member 32. In this way, the drug in the container can be administered to the patient via the conduit.

  However, such a medical multi-chamber container often stores the liquid medicine in the storage chamber 11 to which the medicine discharge member 32 is attached. Therefore, before opening the partition weak seal portion 20, the rubber plug is opened. If the conduit is inserted into the medicine, the medicine before mixing may be discharged from the medicine discharging member 32.

  The present invention has been made to solve the above problem, and an object of the present invention is to provide a medicine discharge method that can reliably prevent the medicine before mixing from flowing out from the discharge section.

  The present invention includes a plurality of storage chambers for storing a drug, a container main body having a sealing part for partitioning each of the storage chambers, and a drug discharge member that is attached to the container main body and discharges the drug from the container main body. A method for discharging a medicine in a medical multi-chamber container provided, wherein the medicine discharging member is formed in a tubular shape, and has one end portion of any of the storage chambers. A main body that can be attached to, a sealing member that seals the other end of the main body and can be opened for use, and is provided on the main body, and seals one end of the main body, And a medicine discharge mechanism for restricting the inflow of medicine from the storage chamber. When the pressure in any of the storage chambers increases, the partition sealing portion is opened and pressure is applied to the medicine discharge member. By the drug discharge mechanism Is released stopped state, conduit by insertion needle connected is piercing the sealing member, to discharge the medication in the container body to the conduit.

  According to the present invention, the drug discharge member is provided with a drug discharge mechanism that regulates the inflow of the drug from the storage chamber in addition to the sealing member. Therefore, even if an attempt is made to accidentally insert a piercing needle into the sealing member before opening the partition sealing portion, the medicine discharge mechanism can prevent the medicine from flowing out of the storage chamber. . Therefore, discharge of the medicine before mixing can be surely prevented.

  In order to solve the above problems, the present invention provides a medical compound comprising a container body having a plurality of storage chambers for storing a medicine and a partition sealing portion configured to be able to be opened when the storage chambers are partitioned. A medicine discharge member attached to the chamber container and capable of discharging the medicine in the container body, wherein the medicine discharge member is formed in a tubular shape, and one end portion of the medicine discharge member can be attached to any of the storage chambers, A sealing member that seals the other end and can be opened for use; and a medicine discharge mechanism that seals one end of the main body and restricts the inflow of the medicine from the storage chamber. The discharge mechanism provides a drug discharge member that releases the sealed state when a predetermined pressure is applied from the storage chamber and allows the drug to flow from the container main body into the main body. It is.

  In addition to the sealing member, the medicine discharge member configured as described above includes a drug discharge mechanism that regulates the inflow of the medicine from the storage chamber. Therefore, when such a medicine discharge member is attached to a medical multi-chamber container, before opening the sealing part for partitioning, even if an insertion of a puncture needle into the sealing member is attempted by mistake, The discharge mechanism can prevent the medicine from flowing out of the storage chamber. Therefore, discharge of the medicine before mixing can be surely prevented. In addition, if such a medicine discharge member is prepared, it is not necessary to provide a mechanism for preventing the discharge of the medicine before mixing in the medical multi-chamber container. As a result, the manufacturing process can be simplified and the manufacturing time can be shortened.

  Various examples of the drug discharge mechanism used for the drug discharge member as described above can be given. For example, the following can be given as examples. That is, the medicine discharge mechanism is arranged in the main body part, seals one end side thereof, and includes a movable member that moves in the main body part by pressure from the container main body, and when the movable member moves to a predetermined position, The sealed state of the medicine discharge mechanism can be released.

  At this time, the medicine discharge mechanism includes a holding member that holds the movable member in a predetermined position, and can be configured to release the sealed state when the movable member is detached from the holding member due to pressure from the storage chamber. .

  Moreover, a medicine discharge | emission mechanism can also be comprised as follows. That is, the medicine discharge mechanism can be provided with a sealing sheet that is disposed in the main body, seals one end thereof, and opens when a predetermined pressure is applied.

  Moreover, the medical multi-chamber container which attached the above medicine discharge | emission members can be comprised as follows, for example. That is, a container main body having a plurality of storage chambers for storing medicines, and a partition sealing portion for partitioning each storage chamber, and the medicine discharge member attached to the container main body, the partition sealing portion being The storage chamber is configured to be openable so as to communicate with each other in use, and the unsealing strength of the partition sealing portion is equal to or smaller than the unsealing strength of the medicine discharge mechanism. be able to.

  Thus, since the opening strength of the partition sealing portion is higher than the sealing release strength of the medicine discharge mechanism, the sealed state of the medicine discharge mechanism can be released after the partition sealing portion is opened. Therefore, only the medicine after mixing can be discharged from the medicine discharge member. The “sealing release strength” refers to the magnitude of the force required to release the sealed state of the medicine discharge mechanism and start the medicine from the storage chamber into the main body. Further, “opening strength” refers to a force required to open even a part of the partition sealing portion and connect adjacent storage chambers. These intensities can be expressed as follows, for example. That is, it can be expressed by the pressing force of the disk when the partition sealing part is unsealed and the medicine discharge mechanism is unsealed by pressing the same capacity portion of the container body with a disk having a diameter of 100 mm. . At this time, it is preferable that the pressing force required for opening the partition sealing portion is 5 to 10 kg larger than the pressing force required for releasing the seal of the medicine discharge mechanism.

  Further, from the viewpoint of preventing the discharge of the medicine before mixing, the medical multi-chamber container can be configured as follows. That is, a container main body having a plurality of storage chambers for storing a drug and a partition sealing portion for partitioning the storage chambers, and a drug discharge member attached to the container main body and capable of discharging the drug from the storage chamber. The partition sealing portion is configured to be openable so as to allow the storage chambers to communicate with each other in use, wherein the medicine discharge member is formed in a tubular shape and has one end thereof. A main body portion attachable to any one of the storage chambers, a sealing member that seals the other end portion of the main body portion and can be opened for use, and is provided on one end portion side of the main body portion; A communication part that allows the medicine from the container to flow in, and the communication part is sealed by adhering a part of the peripheral edge of the container main body to the main body part from the storage chamber. Consists of adhesives that restrict the inflow of chemicals The adhesive portion is opened when a predetermined pressure is applied from the storage chamber, and the opening strength of the partition sealing portion is equal to or smaller than the opening strength of the adhesive portion. it can.

  Even with such a configuration, the communication part is sealed by the adhesive part even if, for example, the puncture needle is mistakenly inserted into the sealing member before opening the partition sealing part. This medicine can be prevented from flowing into the medicine discharge member from the storage chamber. Therefore, the medicine before mixing is reliably prevented from being discharged.

  ADVANTAGE OF THE INVENTION According to this invention, it can prevent reliably that the chemical | medical agent before mixing flows out from a discharge part.

  Hereinafter, embodiments of a medical multi-chamber container according to the present invention will be described with reference to the drawings. In the following description, the same or similar parts may be denoted by the same reference numerals throughout the plurality of embodiments, and description thereof may be omitted.

(First embodiment)
First, a first embodiment of a medical multi-chamber container according to the present invention will be described with reference to the drawings. FIG. 1 is a plan view of a medical multi-chamber container according to the first embodiment, and FIG. 2 is a cross-sectional view of a principal part showing a medicine discharge member in the medical multi-chamber container of FIG.

  As shown in FIG. 1, the medical multi-chamber container 1 includes a container body 3 having a peripheral portion 2 fused and formed in a rectangular shape, and a drug discharge member 32 attached to the container body 3 and discharging a drug. It has. The container body 3 has a first storage chamber 10 and a second storage chamber 11 arranged side by side in the longitudinal direction, and the two storage chambers 10, 11 are partition weak seal portions (partition seal portions) 20. It is partitioned by. The medicine discharge member 32 described above is fused to the peripheral edge 2 of the container body at the stage of manufacture, and is attached so that one end thereof enters the second storage chamber 11. A hanging hole 30 is formed on the container body peripheral edge 2 on the second storage chamber 11 side. The storage chambers 10 and 11 store various drugs a and b, which are undesirable when mixed or dissolved in advance. For example, amino acid infusion and glucose infusion can be stored. Note that a solid or powdered medicine can be stored in one storage chamber.

  The medical multi-chamber container 1 can be a bag-like container formed by heat-sealing or bonding the peripheral portions of two flat layers or multi-layer films. As the material of the film, various resins such as thermoplastic resins such as polyethylene, polypropylene, and polystyrene can be employed.

  Alternatively, if at least the innermost layer of the film constituting the container body 3 is composed of two or more thermoplastics having poor compatibility and different melting points, the weak seal portion 20 for partitioning can be easily formed as described later. Can be formed. Examples of such plastics include those obtained by mixing a resin selected from styrene-based resins, methacrylic ester-based resins, poly-4-methylpentene, polyester, polyamide, and polypropylene with polyethylene. Among these, polyethylene and polypropylene are particularly preferable since safety is confirmed for medical use and a handling method in production is established. The mixing ratio of the two is not particularly limited, but is generally selected from the range of 1: 9 to 9: 1.

  The partition weak seal portion 20 can be configured to be openable in various manners. For example, the partition weak seal portion 20 can be configured by bonding the opposing film surfaces of the container body 3 by heat-sealing. And this weak seal part 20 for partitions is comprised so that both the storage chambers 10 and 11 may be opened when the pressure in the storage chambers 10 and 11 increases and reaches a predetermined pressure.

  As shown in FIG. 2A, the medicine discharge member 32 includes a main body portion 36 formed in a circular tube shape, and restricts the inflow of the medicine from the second storage chamber 11 to one end portion side of the main body portion 36. A drug discharge mechanism 37 is provided. The other end of the main body 36 is sealed with a rubber plug (sealing member) 39 that can be opened with a puncture needle.

  The medicine discharge mechanism 37 is configured as follows. That is, a cylindrical movable member 38 that seals one end of the main body 36 in a liquid-tight state and is slidable within the main body 36 is provided. A first inflow hole 40 through which a medicine can flow is formed at one end of the main body 36, and four second inflow holes 42 are formed on the outer peripheral surface. The diameter of the first inflow hole 40 is smaller than the outer diameter of the movable member 38, and the movement of the movable member 38 into the second storage chamber 11 is restricted by the peripheral edge of the first inflow hole 40. The movable member 38 is formed with an opening 44 at an end facing the rubber plug 39, and the opening 44 communicates with four communication holes 46 formed on the outer peripheral surface of the movable member 38.

  Further, in the initial state, the movable member 38 is disposed at a position in contact with the peripheral edge of the first inflow hole 40 as shown in FIG. 2A, and increases the pressure in the second storage chamber 11. Thus, the inside of the main body 36 is moved by the medicine entering from the first inflow hole 40. And it is comprised so that the communicating hole 46 and the 2nd inflow hole 42 of the main-body part 36 may communicate in the position of FIG.2 (b) which moved the predetermined distance from the initial state. At this time, the force (sealing release strength) necessary for moving the movable member 38 is set to be larger than the opening strength necessary for opening the partition weak seal portion 20.

  Here, the unsealing strength is a force necessary to open a part of the partition weak seal portion 20 and to connect the storage chambers 10 and 11 partitioned by the partition weak seal portion 20. The unsealing strength and the unsealing strength can be expressed by various methods. For example, when the portion having the same capacity of the container body 2 is pressed with a disk having a diameter of 100 mm and the weak sealing portion 20 for partitioning is opened. Or a pressing force when the movable member 38 moves and the communication hole 46 and the second inflow hole 42 communicate with each other. At this time, it is preferable that the pressing force required for opening the partition weak seal portion 20 is 5 to 10 kg smaller than the pressing force required to move the movable member 38.

  Next, the usage method of the medical multi-chamber container comprised as mentioned above is demonstrated. In order to administer the drug in the container 1 to the patient, first, the first storage chamber 10 storing the liquid drug a is pressed by hand or the like, and the pressure in the storage chamber 10 is increased. Thereby, the weak seal part 20 for a partition is opened, the 1st and 2nd storage chambers 10 and 11 are connected, and the chemical | medical agents a and b in each storage chamber 10 and 11 are mixed. Subsequently, the entire first and second storage chambers 10 and 11 are pressed to increase the pressure in the entire communication storage chambers 10 and 11 to operate the medicine discharge mechanism 34. That is, when the pressure in the storage chambers 10 and 11 increases, the movable member 38 of the medicine discharge mechanism 37 is pressed by the medicine that has entered from the first inflow hole 40 as shown in FIG. Move to. When the movable member 38 moves a predetermined distance and the communication hole 46 and the second inflow hole 42 communicate with each other, the mixed medicine flows out from the second storage chamber 11 into the main body 36. Thereafter, when the puncture needle connected with the conduit is inserted into the rubber plug 39, the mixed medicine in the container 1 is administered from the medicine discharge member 32 to the patient through the conduit.

  As described above, according to the present embodiment, since the communication between the second storage chamber 11 and the drug discharge member 32 is regulated by the drug discharge mechanism 37, for example, before the drug discharge mechanism 37 is activated, Even when a puncture needle is inserted into the rubber plug 39, the medicine before mixing in the second storage chamber 11 is prevented from being discharged from the discharge member 32. In this case, since the medicine is not discharged from the medicine discharge member 32 even if the puncture needle is inserted, the user does not operate the medicine discharge mechanism 37 and the partition weak seal portion 20 is not activated. You can recognize that they are not opened. Therefore, by providing such a medicine discharge mechanism 37 in the medicine discharge member 32, the puncture needle is inserted after an appropriate usage, that is, after opening the partition weak seal portion 20 and operating the medicine discharge mechanism 37. Can be used in the correct order.

  Further, when the liquid medicine is stored in the second storage chamber 11, the following advantages are obtained. That is, since the pressing force required for the medicine discharge mechanism 37 to operate is larger than the pressing force required to open the partition weak seal portion 20, when the second storage chamber 11 is pressed, the partition weak seal is pressed. After the part 20 is opened, the medicine discharge mechanism 37 is activated. Therefore, the mixing or dissolution of the drugs a and b stored in the storage chambers 10 and 11 can be terminated before the drug discharge mechanism 37 is activated and the drug can be administered to the patient. Therefore, it can be ensured that the medicine discharged from the medicine discharge member 32 is the one after mixing.

  Further, if the medicine discharge mechanism 37 as described above is provided in the medicine discharge member 32, a mechanism for restricting discharge of the medicine before mixing may not be provided on the container body 3 side. Therefore, if such a medicine discharge member 32 is prepared and attached to the container main body 3, the manufacturing equipment for the multi-chamber container 1 can be simplified and the manufacturing time can be shortened.

  In the present embodiment, an example in which the movable member 38 is used for the medicine discharge mechanism 37 has been shown, but examples of the medicine discharge mechanism having a movable member include the following.

  As shown in FIG. 3A, the drug discharge mechanism 37 of the drug discharge member 32 is provided with an annular holding member 47 on the inner wall surface at one end of the main body 36, and the main body 36 is provided by the holding member 47. The inner diameter is narrowed. A spherical movable member 48 is held by the holding member 47, and the movable member 48 serves as a stopper to prevent the medicine in the second storage chamber 11 from flowing into the main body 36. The holding member 47 is elastically deformed to hold the movable member 48, and when a predetermined pressure is applied from the second storage chamber 11 side, the movable member 48 is detached from the holding member 47. Further, between the holding member 47 and the rubber plug 39, a regulating plate 49 having a large number of small holes 49a is provided. The regulating plate 49 plays a role of regulating the movement of the movable member 48 detached from the holding member 47 to the rubber plug 39 side. However, since the small hole 49a is formed, the regulating plate 49 allows the liquid flowing from the container body 3 to flow. Distribution is possible.

  Even with such a configuration, discharge of the drug before mixing can be prevented. Further, in the above, the restricting plate 49 is provided so that the movable member 48 does not move to the rubber plug 39 side. However, if the movable member 48 is configured as shown in FIG. 49 may not be provided. That is, as shown in the figure, the movable member 48 is attached to the spherical portion 48a constituting the stopper, the rod-shaped portion 48b extending from the spherical portion 48a to the second storage chamber 11 side, and the tip of the rod-shaped portion 48b. And a regulating rod 48c. The restriction rod 48 c extends in the radial direction of the main body portion 36, and its length is longer than the inner diameter of the holding member 47. According to this configuration, when the spherical portion 48 a is detached from the holding member 47, the restriction rod 48 c is caught on the periphery of the holding member 47 and is prevented from coming off. As a result, the movable member 48 can be prevented from moving to the rubber plug 39 side.

  In addition, even if it is a structure other than the above-mentioned, if it is comprised so that the main-body part 36 of the chemical | medical agent discharge member 32 and the 2nd storage chamber 11 may communicate when a movable member moves to a predetermined | prescribed position, the above-mentioned The same effect can be obtained.

(Second Embodiment)
Next, a second embodiment of the medical multi-chamber container according to the present invention will be described with reference to the drawings. FIG. 4 is a cross-sectional view of the medicine discharge member of the medical multi-chamber container according to the second embodiment. Since this embodiment is different from the first embodiment in the configuration of the medicine discharge mechanism in the medicine discharge member, the difference will be mainly described here.

  In the medicine discharge member 32 of the medical multi-chamber container according to this embodiment, the medicine discharge mechanism 50 is configured as follows. As shown in FIG. 4A, a sealing sheet 56 that regulates the outflow of the medicine is disposed at one end of the main body 36 facing the second storage chamber 11, and this sealing sheet 56 is a ring member. It is fixed to the inner wall surface of the main body portion 36 through 54. The sealing sheet 56 is made of an elastic material, and is elastically deformed when the pressure in the storage chambers 10 and 11 is increased.

  An insertion member 58 is fixed between the sealing sheet 56 and the rubber plug 39 at a position away from the sealing sheet 56 by a predetermined distance. The insertion member 58 includes a rod-like support portion 58a fixed to the inner wall surface of the main body portion 36, and a needle portion 58b disposed on the support portion 58a, as shown in FIG. 4 (b). The needle portion 58b can be inserted into the elastically deformable sealing sheet 56 and broken. Here, in order to break the sealing sheet 56, it is necessary to increase the pressure in the storage chambers 10 and 11 and to elastically deform the sealing sheet 56 to reach the insertion member 58, but this pressure is generated. Therefore, the force which presses the container main body 3 is set so that it may become larger than the force required in order to open the weak seal part 20 for partitions. The details are the same as in the first embodiment.

  In order to use this multi-chamber container, as in the first embodiment, after pressing the first storage chamber 10 to open the partition weak seal portion 20, the entire storage chambers 10, 11 communicated are pressed. Then, the medicine discharge mechanism 50 is operated. That is, as shown in FIG. 4B, by increasing the pressure in the storage chambers 10 and 11, the sealing sheet 56 is elastically deformed and bulged toward the rubber plug 39 side. Then, when the sealing sheet 56 swells to a predetermined position, it comes into contact with the needle portion 58b and breaks, whereby the medicine in the storage chambers 10 and 11 flows out from the medicine discharge member 32.

  Thus, according to the present embodiment, since the drug discharge mechanism 37 is provided at one end of the drug discharge member 32 on the second storage chamber 11 side, the drug before mixing is the same as in the first embodiment. It is possible to prevent the medicine discharge member 32 from flowing out. Further, the medicine discharged from the medicine discharge member 32 is adjusted by adjusting the sealing release strength force for operating the medicine discharge mechanism 50 and the opening strength for opening the partition weak seal portion 20 as described above. Can be ensured after mixing.

  If such a medicine discharge member 32 is prepared, the manufacture of the multi-chamber container can be simplified as in the first embodiment.

(Third embodiment)
Next, a third embodiment of the medical multi-chamber container according to the present invention will be described with reference to the drawings. FIG. 5 is a cross-sectional view of the medicine discharge mechanism of the medical multi-chamber container according to the third embodiment. Since this embodiment is different from the first embodiment in the configuration of the medicine discharge mechanism in the medicine discharge member, the difference will be mainly described here.

  In the medicine discharge member of the medical multi-chamber container according to the present embodiment, the medicine discharge mechanism is configured as follows. As shown in FIG. 5A, the medicine discharge mechanism 60 includes a cylindrical member 64 that is held by the main body 36. A flange 64 a is provided at one end of the cylindrical member 64, and the flange 64 a is locked in a liquid-tight state to an annular holding portion 66 formed on the inner wall surface of the main body 36.

  A sealing sheet 68 for sealing the inside of the cylinder is attached to the end of the cylindrical member 64 on the flange 64a side. The sealing sheet 68 is composed of two sheets, and a part of them is superposed and heat-sealed or bonded to form a weak seal portion 68a. The weak seal 68a is opened when a predetermined pressure is applied, and the medicine in the storage chambers 10 and 11 flows out to the rubber plug 39 side. The force required to open the weak seal portion 68a is set larger than the force required to open the partition weak seal portion 20 as in the above embodiments.

  In order to use this multi-chamber container, as in the first embodiment, after pressing the first storage chamber 10 to open the partition weak seal portion 20, the entire storage chambers 10, 11 communicated are pressed. Then, the medicine discharge mechanism 60 is operated. That is, as shown in FIG. 5B, when the pressure in the storage chambers 10 and 11 is increased, the weak seal portion 68a of the sealing sheet 68 is opened, and the medicine in the storage chambers 10 and 11 is moved to the rubber plug 39 side. Flows out.

  Thus, according to this embodiment, since the medicine discharge mechanism having the above-described configuration is provided, it is possible to prevent the medicine before mixing from flowing out of the medicine discharge member 32 as in the first embodiment. . In addition, the use of such a medicine discharge member 60 facilitates the manufacture of the multi-chamber container.

  In this embodiment, the sealing sheet 68 is configured by superimposing two sheets. However, the present invention is not limited to this, and it is only necessary that the sealing sheet is opened by the action of pressure. . For example, as shown in FIG. 6, the sealing sheet 68 may be constituted by a single sheet, and a part 68 b having a thickness smaller than that of the other part may be provided in a part thereof. In this case, when a pressure is applied to the thin portion, the sealing sheet 68 is broken and the medicine can flow out.

  Further, in the present embodiment, the medicine discharge mechanism 60 is configured by providing the cylindrical member 64 having the sealing sheet 68 in the medicine discharge member 32. However, the following may be used. That is, as shown in FIG. 7A, a sealing sheet 69 may be directly attached to the main body portion 36 of the medicine discharge member 32. Even if it is such a structure, the effect similar to the above can be acquired. As shown in FIG. 7 (b), the sealing sheet 69 has a structure in which a single sealing sheet 69 is fused to the opening periphery of the main body 36, and when a predetermined pressure is applied, The sealing sheet 69 can be removed. Alternatively, as shown in FIG. 7C, a fragile portion 69 a may be formed, and a sealing sheet 69 that can be easily opened from that portion may be attached to the opening of the main body 36. Further, as shown in FIG. 7 (d), two sheets can be overlapped and fused, and the fused portion can be opened as a weak seal portion 69b.

  In the said 2nd and 3rd embodiment, although the sealing sheet 56,68 was used for the chemical | medical agent discharge | emission mechanism 50,60, the structure of the sealing sheet is not limited to these, A predetermined | prescribed pressure acts Then, what is necessary is just to be comprised so that it may open. Further, the position where the sealing sheet is disposed is not particularly limited as long as the sealing sheet is disposed at a position where pressure from the storage chamber acts and discharge of the medicine from the rubber plug 39 is restricted.

(Fourth embodiment)
Next, a fourth embodiment of the medical multi-chamber container according to the present invention will be described with reference to the drawings. FIG. 8 is a cross-sectional view of the medical multi-chamber container according to the fourth embodiment. In the present embodiment, unlike each of the above embodiments, the medicine discharge member itself is not provided with means for regulating the discharge of the medicine before mixing, but by combining the medicine discharge member and the container body, It constitutes a means to regulate emissions.

  As shown in FIG. 8A, in the medicine discharge member 32 of the medical multi-chamber container according to the present embodiment, the following communicating portion 72 is provided at one end portion of the main body portion 36. The communication portion 72 includes a first tube portion 74 connected to the main body portion 36 and a second tube portion 76 that is connected to the first tube portion 74 and has an outer peripheral surface formed in a taper shape. Sealed with a member 78. A plurality of communication holes 76 a communicating with the inside are formed on the outer peripheral surface of the second pipe portion 76. Moreover, this communication part 72 is connected to the container main body 3 as follows. That is, the peripheral edge portion 2 of the container body 3 is heat-sealed to the outer peripheral surfaces of the first tube portion 74 and the second tube portion 76. Here, the peripheral edge portion 2 of the container body 3 is firmly fused to the first tube portion 74 to form the strong seal portion 2a, while the second tube portion 76 is weaker than this, and a weak seal for partitioning. The weak seal part (adhesion part) 2b fuse | melted by the intensity | strength stronger than the part 20 is comprised.

  In order to manufacture the multi-chamber container 1, for example, the peripheral edge portion 2 of the container body 3 and the weak seal portion 20 for partitioning are fused together with one side edge of each of the storage chambers 10 and 11 open. The medicine discharge member 32 is fused to the peripheral edge 2. At this time, the fusion strength between the first tube portion 74 and the second tube portion 76 and the peripheral edge portion 2 is adjusted as described above. Next, the lid member 78 is inserted from the other end side of the main body, the tip of the communication portion 72 is sealed, and the rubber plug 39 is sealed. Finally, a medicine is injected from the openings at the side edges of the storage chambers 10 and 11, and the openings are sealed to complete the multi-chamber container.

  It should be noted that the medicine discharge member 32 to which the rubber plug 39 and the lid member 78 are attached in advance can be used for fusion to the peripheral portion 2 of the container body as described above. At this time, a rubber stopper can also be provided by injection-molding the thermoplastic elastomer at the other end of the medicine discharge part 32.

  In order to use this multi-chamber container, as in the first embodiment, after pressing the first storage chamber 10 to open the weak seal portion 20 for partitioning, the entire storage chambers 10 and 11 communicated are pressed. . That is, as shown in FIG. 8B, the weak seal portion 2 b is peeled off from the second pipe portion 76 by increasing the pressure in the storage chambers 10 and 11. Thereby, the medicine in the storage chambers 10 and 11 flows into the main body 36 through the communication hole 76a. In addition, since the strong seal | sticker part 2a is melt | fused firmly to the 1st pipe part 74, a chemical | medical agent does not flow out from this part.

  Thus, according to this embodiment, since the communication part 72 of the chemical | medical agent discharge member 32 is melt | fused by the container main body peripheral part 2, unless this fusion | melting part, ie, the weak seal part 2b, is opened, a storage chamber The drug does not flow from 11 into the drug discharge member 32. Therefore, similarly to the first embodiment, it is possible to reliably prevent the medicine before mixing from flowing out of the discharge member 32.

  In the present embodiment, the communication portion 72 is formed in a cylindrical shape, but may be formed as follows. That is, as shown in FIG. 9, a relatively sharp corner is provided on the outer periphery of the communication portion 72 to form an elliptical cross section. By doing so, the adhesion between the outer peripheral surface of the communicating portion 72 and the container main body peripheral edge portion 2 is enhanced, and the container can be easily manufactured because it is easily fused.

  It should be noted that the adhesion between the container body peripheral edge 2 and the communication portion 72 is not necessarily heat-sealed as described above, and any method can be used as long as it can be adhered with appropriate strength. Further, the weak seal portion is not provided on the peripheral edge portion 2 of the container body 3, the communication pipe 72 and the peripheral edge portion 2 are firmly fused, and the lid member 78 is applied with a predetermined pressure stronger than the opening pressure of the partition weak seal portion. It is also possible to configure so as to be removed. In addition, when taking this structure, the cover member 78 comprises the movable member of 1st Embodiment.

  In each of the above embodiments, the pressure for operating the medicine discharge mechanism is set to be larger than the pressure for opening the partition weak seal portion 20, but the pressure for opening the partition weak seal portion. The drug discharge mechanism can be configured to operate with a pressure equal to.

  Moreover, in each said embodiment, although the other end part of the chemical | medical agent discharge member 32 is sealed with the rubber stopper 39, if it can open in use, it will not specifically limit.

  Moreover, in the medical multi-chamber container of each said embodiment, although it is comprised so that two types of chemical | medical agents can be mixed, it is not limited to this, It can also be made to provide three or more storage chambers. .

  The container main body to which the medicine discharge member 32 according to the present invention is attached is not limited to the one described above, and a container configured to partition two or more storage chambers in which medicines are stored by a partition sealing portion. If it is a main body, it will not specifically limit. For example, the opening strength of the partition weak seal portion may be smaller than the sealing release strength of the medicine discharge mechanism. Further, in the container body of each of the above embodiments, the partition sealing portion of the present invention is configured as a weak seal portion by fusing the film surface, but is not limited to this, and a predetermined external force acts. It may be configured to be opened when it is done. For example, the partition sealing portion can also be configured by concave-convex fitting between a ridge and a concave provided on the film surface.

  Moreover, in the said 1st-3rd embodiment, although the chemical | medical agent discharge member 32 is attached to the container main body peripheral part 2 by heat fusion, depending on the material which comprises the container main body 3, high frequency welding, an ultrasonic seal, etc. A method can also be used. Even in other methods, the connection method is not particularly limited as long as the storage chamber 11 of the container body 3 and the medicine discharge member 32 are connected in a liquid-tight state.

1 is a plan view of a first embodiment of a medical multi-chamber container according to the present invention. It is sectional drawing of the chemical | medical agent discharge member which concerns on the medical multiple chamber container of FIG. It is sectional drawing which shows the modification of the chemical | medical agent discharge member of FIG. It is sectional drawing of the chemical | medical agent discharge member which concerns on the medical multiple chamber container of 2nd Embodiment. It is sectional drawing of the chemical | medical agent discharge member which concerns on the medical multiple chamber container of 3rd Embodiment. It is sectional drawing which shows the other example of the sealing sheet in the chemical | medical agent discharge member of FIG. It is sectional drawing which shows the modification of the chemical | medical agent discharge member of FIG. It is sectional drawing which shows 4th Embodiment of the medical multi-chamber container which concerns on this invention. It is a perspective view which shows the other example of the chemical | medical agent discharge member of FIG. It is a top view which shows an example of the conventional medical multiple chamber container. FIG. 9 is a cross-sectional view taken along line XX in FIG. 8.

Explanation of symbols

1 Medical multi-chamber container 2 Peripheral part 2b Weak seal part (adhesion part)
3 Container body 10, 11 Storage chamber 20 Weak seal part for partition (sealing part for partition)
32 Drug discharge member 37, 50, 60 Drug discharge mechanism 36 Main body 38 Movable member 56, 68, 69 Sealing sheet

Claims (4)

A medical use comprising: a plurality of storage chambers for storing medicines; a container body having a sealing portion for partitioning each of the storage rooms; and a medicine discharge member attached to the container body and discharging the medicine from the container body. A method for discharging a drug in a multi-chamber container,
The medicine discharge member is formed in a tubular shape, and has a main body part whose one end part can be attached to any of the storage chambers, and a sealing member that seals the other end part side of the main body part and can be opened for use. A medicine discharge mechanism that is provided in the main body portion, seals one end portion side of the main body portion, and regulates the inflow of the medicine from the storage chamber,
When the pressure in any of the storage chambers is increased, the partition sealing portion is opened, pressure is applied to the drug discharge member, and the sealed state by the drug discharge mechanism is released,
A method for discharging a drug from a medical multi-chamber container, wherein a drug inserted in the container body is discharged into the conduit by inserting a needle into which the conduit is connected into the sealing member.   The medicine discharge mechanism includes a movable member that is disposed in the main body, seals one end thereof, and moves in the main body by pressure from the container main body, and the movable member moves to a predetermined position. Then, the medicine discharging method according to claim 1, which is configured to release the sealing state.   The medicine discharge mechanism includes a holding member that holds the movable member in a predetermined position, and releases the sealed state when the movable member is detached from the holding member due to pressure from the storage chamber. The method for discharging a medicine according to claim 2, which is constituted. The drug discharge method according to claim 1, wherein the drug discharge mechanism includes a sealing sheet that is disposed in the main body portion, seals one end thereof, and opens when a predetermined pressure is applied.

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