JP4734093B2 - Cosmetics - Google Patents
Cosmetics Download PDFInfo
- Publication number
- JP4734093B2 JP4734093B2 JP2005326715A JP2005326715A JP4734093B2 JP 4734093 B2 JP4734093 B2 JP 4734093B2 JP 2005326715 A JP2005326715 A JP 2005326715A JP 2005326715 A JP2005326715 A JP 2005326715A JP 4734093 B2 JP4734093 B2 JP 4734093B2
- Authority
- JP
- Japan
- Prior art keywords
- extract
- brown rice
- germinated brown
- rice bran
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Cosmetics (AREA)
Description
本発明は、皮膚の老化防止や肌荒れの予防・改善に有効な化粧料に関し、詳しくは、真皮線維芽細胞賦活作用とコラーゲン合成促進作用とを併せ持ち、それら作用の相乗的効果により皮膚の老化防止や肌荒れの予防・改善に高い有効性を示すと共に、生体安全性にもすぐれた天然物由来成分を含んでなり、皮膚を健常で且つ若々しい状態に保持し或いは改善するために用いて有用な化粧料に関する。 The present invention relates to a cosmetic effective for preventing skin aging and preventing or improving rough skin. More specifically, the present invention has both a dermal fibroblast activation action and a collagen synthesis promoting action, and the synergistic effect of these actions prevents skin aging. It has a high effectiveness in preventing and improving rough skin and contains natural ingredients with excellent biological safety, and is useful for maintaining or improving the skin in a healthy and youthful state. Related to cosmetics.
皮膚の老化は、加齢に伴う細胞増殖・分化の不活化、ホルモン分泌の低下などの内的要因と、太陽光(紫外線)に誘発される活性酸素による細胞・組織の損傷或いは細胞外マトリックス成分の量的低下、炎症などの外的要因が複雑に絡み合って生ずる現象である。それらのうち、内的要因に基づく皮膚の老化は、真皮線維芽細胞の活性低下や増殖能の低下、さらにはコラーゲン、エラスチン、ヒアルロン酸などの細胞外マトリックス成分の減少により、皮膚組織が柔軟性や弾力を失うことや、表皮基底細胞の不活化により、皮膚角質層のバリア機能、皮脂分泌機能、水分保持機能が低下することによって生じ、皮膚の形態的・生理的変化としては、シワ、タルミ、肌荒れなどの症状として現れる。
この皮膚の老化を防ぎ、皮膚を健全で若々しい状態に保持するため、従来より種々の活性成分の使用が提案され、それら成分を配合した化粧品が上市されている。例えば、ビタミンC類、ビタミンE類などの抗酸化剤、グリチルリチン酸などの抗炎症剤、各種紫外線吸収剤、α-ヒドロキシカルボン酸、胎盤抽出液、γ-アミノ-β-ヒドロキシ酪酸などの細胞賦活成分、コラーゲン、エラスチン、ヒアルロン酸などの細胞外マトリックス成分、尿素などの保湿剤等がそれである。
しかしながら、それら成分は一般に、上述した皮膚老化要因のうちの一つを防止或いは改善することに与るに過ぎないため、それら成分を配合した従来の化粧料によっては、真に満足し得る皮膚老化防止効果は得られないのが現状である。 また、成分の種類によっては、皮膚刺激性や皮膚感作性を有するなど生体に対する安全性に問題があったり、或いは細胞の活性化、増殖作用が十分では無いなどの難点もある。
Skin aging is caused by internal factors such as inactivation of cell proliferation / differentiation with age, decreased hormone secretion, and damage of cells / tissues caused by active oxygen induced by sunlight (ultraviolet rays) or extracellular matrix components. This is a phenomenon that is caused by complex intertwining of external factors such as quantitative decrease in inflammation and inflammation. Of these, aging of the skin based on internal factors causes skin tissue flexibility due to decreased activity of dermal fibroblasts and decreased proliferation ability, as well as decreased extracellular matrix components such as collagen, elastin, and hyaluronic acid. Loss of elasticity and inactivation of the epidermal basal cells, resulting in a decrease in the skin's stratum corneum barrier function, sebum secretion function, and water retention function. Skin morphological and physiological changes include wrinkles and tarmi. Appears as symptoms such as rough skin.
In order to prevent this skin aging and keep the skin healthy and youthful, the use of various active ingredients has been proposed and cosmetics containing these ingredients have been put on the market. For example, antioxidants such as vitamin C and vitamin E, anti-inflammatory agents such as glycyrrhizic acid, various ultraviolet absorbers, α-hydroxycarboxylic acid, placental extract, and cell activation such as γ-amino-β-hydroxybutyric acid Ingredients, extracellular matrix components such as collagen, elastin and hyaluronic acid, humectants such as urea, and the like.
However, since these ingredients generally only serve to prevent or improve one of the above-mentioned skin aging factors, depending on the conventional cosmetics containing these ingredients, the skin aging that is truly satisfactory At present, the prevention effect cannot be obtained. In addition, depending on the type of component, there are problems such as having skin irritation and skin sensitization, and there are problems with safety against living bodies, or cell activation and proliferation are not sufficient.
本発明者らは、従来の化粧料にみられる上述のごとき問題点に鑑み、皮膚の老化、肌荒れ等の諸要因に対して複合的、多面的に作用することにより皮膚の老化防止や肌荒れの予防・改善に高い有効性を示すと共に、皮膚に対する安全性の点でも十分満足し得る新たな化粧料配合成分を見出すべく鋭意研究を行った結果、発芽玄米の糠のエキス、さらにはその酵素分解物或いは発酵物が、真皮線維芽細胞の賦活作用と真皮に於けるコラーゲン合成の促進作用とを併せ持つと共に、米由来の成分であることから生体安全性にもすぐれ、上記の目的に合致するものであることを知り、本発明を完成するに至った。 In view of the above-mentioned problems seen in conventional cosmetics, the present inventors have combined and multifaceted action against various factors such as skin aging and rough skin, thereby preventing skin aging and rough skin. As a result of diligent research to find new cosmetic ingredients that are highly effective for prevention and improvement, and that are also sufficiently safe for the skin, germinated brown rice koji extract and its enzymatic degradation The product or fermented product has both the dermal fibroblast activation effect and the collagen synthesis promotion effect in the dermis, and is also an ingredient derived from rice, so it has excellent biological safety and meets the above objectives. As a result, the present invention has been completed.
米糠或いは米糠由来成分を化粧料配合原料として利用することについては、従来より種々の提案がなされている。
例えば、特開昭53-015434号公報には、米糠に麹菌を接種、培養して得られる培養物を含み、皮膚の新陳代謝を促進する効果を有する皮膚化粧料が、特開昭59-154971号公報には、米糠を炒ってアルコールで抽出した美肌剤が、特開昭62-187404号公報には米糠から得られるスフィンゴ糖脂質とステロイド配糖体或いはトリテルペノイド配糖体を含み、皮膚の老化防止に有効な化粧料が、特開昭62-106008号公報及び特開平01- 093521号公報には米糠からの浴剤が、特開平01-066106号公報には、米糠に含まれる多糖類を配合した肌荒れ改善に有効な化粧料が、特開平02-053705公報には、米糠原料から得られる水溶性抗酸化物を含有してなり、酸化による皮膚の老化や皮膚機能の損傷の予防・改善に有効な化粧料が、特開平04-368314号公報には、米糠或いはそのエキスを含み、皮膚改善作用と美肌化作用を示す貼付剤が、特開平05-221844号公報には、米糠のアルカリ抽出液の酵素分解物を含む老化防止化粧料が、特開平07-304648号公報及び特開2000-264834号公報には、米糠の中性媒体抽出物及び酸性水性媒体抽出物をそれぞれ有効成分として含む美白化粧料が、又特開平2004-083594号公報には、米糠の中性媒体抽出物の酵素処理分解物を配合した美白化粧料がそれぞれ開示されている。
しかしながらそれら公知文献には、米糠として本発明に云う発芽玄米から得られる糠を使用することを具体的に開示したものは全く見当たらない。
又、後に試験例1及び2に示す通り、糠のエキスの有する線維芽細胞賦活作用とコラーゲン合成促進作用は、米糠のなかでも特に発芽玄米の糠に顕著に認められるが、かかる事実についても、当然ながら公知文献中には何らの記載もなされておらず又これを示唆するものすら示されていない。
Various proposals have been made for using rice bran or rice bran-derived ingredients as cosmetic ingredients.
For example, Japanese Patent Application Laid-Open No. Sho 53-015434 discloses a skin cosmetic that has an effect of promoting metabolism of skin, including a culture obtained by inoculating and culturing koji mold on rice bran. The gazette includes a skin beautifying agent obtained by roasting rice bran and extracted with alcohol, and Japanese Patent Application Laid-Open No. 62-187404 contains a sphingoglycolipid obtained from rice bran and a steroid glycoside or triterpenoid glycoside. An effective cosmetic material is disclosed in JP-A-62-106008 and JP-A-01-093521 in which a bath agent from rice bran is incorporated, and in JP-A-01-066106, a polysaccharide contained in rice bran is incorporated. Japanese Patent Laid-Open No. 02-053705 discloses a cosmetic material effective for improving rough skin, which contains a water-soluble antioxidant obtained from rice bran raw material, and is used to prevent and improve skin aging and skin function damage due to oxidation. An effective cosmetic is disclosed in JP 04-368314 A which contains rice bran or an extract thereof. In addition, a patch exhibiting a skin improving action and a skin beautifying action is disclosed in Japanese Patent Laid-Open No. 05-221844, an anti-aging cosmetic containing an enzymatic degradation product of an alkaline extract of rice bran is disclosed in Japanese Patent Laid-Open No. 07-304648 and Japanese Laid-Open Patent Publication No. 2000-264834 discloses a whitening cosmetic containing a neutral rice medium extract and an acidic aqueous medium extract as active ingredients, and Japanese Laid-Open Patent Publication No. 2004-083594 discloses a neutral rice bran medium. Whitening cosmetics containing enzyme-decomposed degradation products of the extract are disclosed.
However, none of these known documents specifically disclose the use of rice bran obtained from germinated brown rice according to the present invention as rice bran.
Moreover, as shown in Test Examples 1 and 2 later, the fibroblast activation action and collagen synthesis promoting action of the koji extract are remarkably recognized in the koji of the germinated brown rice, especially in the rice koji. Of course, there is no description in the known literature, nor is there any suggestion of this.
一方、発芽米を化粧料配合原料として用いることに関してもいくつかの提案がなされており、例えば特開平07-002628号、同07-10733号、同07-41426号、同07-187992、同07-252129号及び同08-119870号の各公報には、発芽米の抽出物、発芽米或るいはその抽出物の酵素もしくは麹処理物、さらにはそれらの発酵物などを、育毛剤、保湿・老化防止化粧料、活性酸素消去剤、入浴剤、表皮角質層健全化剤及びターンオーバー正常化剤の有効成分としてそれぞれ用いることが開示されている。
しかしながら、それら公知発明の奏する化粧効果は、入浴剤や表皮角質層健全化剤或いはターンオーバー正常化剤の場合はもとより、特開07-010733号の保湿・老化防止化粧料にしても、その効果として皮膚表面の皮溝及び皮丘の健常化効果が挙げられているに過ぎないことから明らかな通り、いずれも表皮の健全、健常化に関わるものであるか、もしくは特開平07-41426号の活性酸素消去剤のように、紫外線によって誘発される活性酸素などの外的要因に基づく皮膚の老化や肌荒れの改善に関わるものであって、発芽玄米の糠由来の成分の示す真皮線維芽細胞賦活作用によって、加齢などの内的要因に起因する真皮の老化、細胞・組織の活性低下を防ぎ、さらにはコラーゲンの合成を促進することで、皮膚の弾力を保ち、肌荒れやツヤの低下、さらには皺の発生を防ぐなど、皮膚を内部から健全、健常なものとする本発明の化粧料とは、明らかに作用機序並びにそれによって得られる効果を異にしている。
しかも、それら公知発明に於いて上記の角質層健全化作用などの有効性が確認されているのは、もっぱら発芽米の胚乳部についてであって、糠部の有する有効性に関しては具体的に何も示されておらず、従ってそれら公知発明からは、発芽玄米の糠を積極的に化粧料配合成分として利用するとの技術思想は、これを全く読み取ることができない。
On the other hand, several proposals have also been made regarding the use of germinated rice as a raw material for cosmetics, such as JP-A Nos. 07-002628, 07-10733, 07-41426, 07-187992, and 07. -252129 and 08-119870 disclose germinated rice extract, germinated rice or enzyme or koji-treated product of the extract, fermented product thereof, hair restorer, moisturizer, It is disclosed that they are used as active ingredients of anti-aging cosmetics, active oxygen scavengers, bathing agents, epidermal stratum corneum cleansing agents and turnover normalizing agents, respectively.
However, the cosmetic effect exhibited by these known inventions is not limited to bathing agents, epidermal stratum corneum cleansing agents, or turnover normalizing agents, but also to moisturizing and anti-aging cosmetics described in JP 07-010733 A. As it is clear from the fact that only the skin groove and skin mound health effects are mentioned, both are related to the health and health of the epidermis, or JP 07-41426 A Like active oxygen scavengers, it is related to the improvement of skin aging and rough skin based on external factors such as active oxygen induced by ultraviolet rays, and it activates dermal fibroblasts, which is indicated by the components derived from rice bran The action prevents aging of the dermis due to internal factors such as aging, cell and tissue activity decline, and further promotes the synthesis of collagen to maintain skin elasticity and reduce skin roughness and gloss. It sounds like preventing the occurrence of wrinkles, the skin from the inside to the cosmetic and the of the present invention to healthy ones, are different from the effect obtained clearly action mechanism and thereby.
In addition, in these known inventions, the effectiveness of the above-mentioned stratum corneum sounding action has been confirmed only for the endosperm portion of germinated rice, and what specifically is the effectiveness of the buttocks? Therefore, from these known inventions, the technical idea that the germinated brown rice bran is actively used as a cosmetic ingredient cannot be read at all.
以上の従来技術の現状よりすれば、本発明で有効成分として用いる発芽玄米の糠のエキスやその酵素分解物或いは発酵物が、顕著な真皮線維芽細胞賦活作用とコラーゲン合成促進作用とを併せ持ち、それら両作用の相乗効果によって真皮を健全、健常化することによって、すぐれた皮膚老化防止効果、肌荒れの予防、改善効果を奏することについては、これを到底予測し得ないことが明らかである。 According to the current state of the above prior art, the germinated brown rice bran extract used as an active ingredient in the present invention and its enzymatic degradation product or fermented product have a remarkable dermal fibroblast activation action and collagen synthesis promoting action, It is clear that it cannot be predicted at all about the excellent effect of preventing skin aging, preventing rough skin, and improving the skin by making the dermis healthy and healthy by the synergistic effect of these two actions.
即ち本発明は、発芽玄米の糠、そのエキス、それら糠又はエキスの酵素分解物及びそれら糠又はエキスの発酵物から選ばれた1種又は2種以上を配合したことを特徴とする化粧料に関するものである。
ここで発芽玄米の糠とは、発芽玄米を精米して発芽米とする際に得られる胚芽と胚乳の外皮を主体としてなるものを言うが、これに胚乳の成分が多少含まれていても差し支えない。
又、本発明に於いて化粧料なる文言は、所謂化粧料のほかに医薬部外品をも含む広義で用いる。
That is, the present invention is bran of brown rice, a cosmetic which is characterized in that the extract was formulate one or more kinds selected from enzymatic degradation thereof bran or extract and fermentation thereof bran or extract Is .
Here, the germinated brown rice refers to a rice mainly composed of germ and endosperm obtained when the germinated brown rice is made into germinated rice, but it may contain some components of endosperm. Absent.
In the present invention, the term cosmetic is used in a broad sense including so-called cosmetics and quasi-drugs.
発芽玄米の糠或いはそのエキスは、真皮線維芽細胞の活性化作用とコラーゲン産生促進作用とを併せ持っており、それら作用の複合に基づく相乗的な抗老化作用により、本発明の化粧料は、皮膚の弾力性やハリを向上させて、シワやタルミなどの皮膚の老化や不健全化の症状を予防或いは改善し、皮膚を真に健全で若々しい状態に維持する効果を奏する。又、上記の糠或いはそのエキスの酵素分解物或いは発酵物は、いずれも糠或いはエキスそれ自体と同様の強い真皮線維芽細胞賦活作用及びコラーゲン合成促進作用を有するだけでなく、酵素処理或いは発酵処理を施されたことによって、糠特有の匂いが軽減され或いは消失するという利点を有しており、さらにそれに加えて、エキスの特性、例えば抽出液であればその流動特性が改善される結果、ろ過などの固液分離操作が容易となり、製造工程に於ける作業効率が大幅に向上するとの利点をも有している。
又、本発明化粧料で用いる上記の活性成分は、皮膚に対する刺激性がなく、このため本発明の化粧料は生体安全性にも大変すぐれている。
The germinated brown rice bran or extract thereof has both the dermal fibroblast activation effect and the collagen production promoting effect. By the synergistic anti-aging effect based on the combination of these effects, the cosmetic of the present invention Improves the elasticity and firmness of the skin, prevents or ameliorates skin aging and unhealthy symptoms such as wrinkles and tarmi, and maintains the skin in a truly healthy and youthful state. In addition, the enzyme decomposition product or fermented product of the above koji or its extract not only has the strong dermal fibroblast activation action and collagen synthesis promoting action similar to koji or the extract itself, but also an enzyme treatment or fermentation treatment. As a result, the characteristics of the extract, for example, the flow characteristics of an extract solution are improved. The solid-liquid separation operation such as the above becomes easy, and there is an advantage that the working efficiency in the manufacturing process is greatly improved.
Further, the above-mentioned active ingredient used in the cosmetic of the present invention has no irritation to the skin, and therefore the cosmetic of the present invention is very excellent in biological safety.
以下、本発明について詳細に説明する。
本発明に於いて、発芽玄米の糠としては、例えばコシヒカリ、ササニシキ、アキタコマチ、ヒトメボレなどの粳米や糯米を常法に従って発芽処理して得られる発芽玄米を、通常行われる精米方法によって精米した際に得られる糠を用いることができる。
発芽玄米の精米に当たって、精米歩合をどの範囲とするかについては特に制限はないものの、糠或るいはそのエキスの示す有効性の観点からは、精米歩合を一般に80%以上、特に90%以上とすることが好ましく、かかる精米歩合として得られる糠が本発明に於いて好適に用いられる。
Hereinafter, the present invention will be described in detail.
In the present invention, germinated brown rice, such as Koshihikari, Sasanishiki, Akitakomachi, human mebore, etc. The resulting soot can be used.
Although there is no particular limitation on the range of the milling ratio in germination brown rice, the milling ratio is generally 80% or more, particularly 90% or more, from the viewpoint of the effectiveness of the rice bran or the extract. It is preferable to use rice bran obtained as such a rice milling ratio in the present invention.
本発明の化粧料には、上記の発芽玄米の糠それ自体或いはこれを抽出溶媒で抽出して得られるエキス、さらにはそれら糠或いは抽出エキスの酵素分解物もしくは発酵物の1種又は2種以上が有効成分として配合される。
酵素分解物或いは発酵物は、先に述べた通り、糠或いは抽出エキスと同様のすぐれた線維芽細胞賦活作用及びコラーゲン合成促進作用を有するだけでなく、酵素処理或いは発酵処理を施されたことによって、米糠特有の匂いが軽減されたり、或いは抽出エキスの流動特性が改善されて製造効率が向上するなどの利点を有している。
The cosmetics of the present invention include the above germinated brown rice koji itself or an extract obtained by extracting this with an extraction solvent, and further, one or more of these koji or an enzymatic degradation product or fermented product of the extract. Is blended as an active ingredient.
As described above, the enzyme-decomposed product or fermented product not only has excellent fibroblast activation and collagen synthesis promoting effects similar to those of koji or extract, but also has been subjected to enzyme treatment or fermentation treatment. In addition, the odor peculiar to rice bran is reduced, or the flow characteristics of the extract are improved, and the production efficiency is improved.
発芽玄米の糠の抽出エキスは、発芽玄米の糠を、必要に応じて予めこれに微粉末化処理、脱脂処理などを施した上、浸漬法、向流抽出法など適宜の手段により抽出溶媒と接触させることによって調製することができる。又、超臨界抽出法を用いてもよい。 The extract of germinated brown rice bran is obtained by subjecting germinated brown rice bran to an extraction solvent by an appropriate method such as a dipping method or a countercurrent extraction method after subjecting it beforehand to a pulverization treatment and a degreasing treatment. It can be prepared by contacting. A supercritical extraction method may also be used.
抽出溶媒としては、水;メタノール、エタノール、プロパノールなどの低級アルコール類、オレイルアルコール、ステアリルアルコール、オクチルドデカノールなどの高級アルコール類;エチレングリコール、プロピレングリコール、1,3−ブチレングリコール、グリセリンなどの多価アルコール類;酢酸エチル、酢酸ブチル、プロピオン酸メチル、トリオクタン酸グリセリルなどのエステル類;アセトン、メチルエチルケトンなどのケトン類;エチルエーテル、イソプロピルエーテルなどのエーテル類;n−ヘキサン、トルエン、クロロホルムなどの炭化水素系溶媒などが挙げられ、それらは単独でもしくは二種以上混合して用いられる。
なお、得られる抽出エキスの線維芽細胞賦活作用或いはコラーゲン産生促進作用の観点から、本発明に於いては、それら溶媒のうちでも特に高極性のものが好適に使用される。さらには化粧料への幅広い適用が可能であるという点からも、水、低級アルコール類及び多価アルコール類から選ばれた一種の単独溶媒又は二種以上の混合溶媒の使用が好ましく、なかでも水の単独使用が最も好ましい。
As an extraction solvent, water; lower alcohols such as methanol, ethanol, and propanol; higher alcohols such as oleyl alcohol, stearyl alcohol, and octyldodecanol; many solvents such as ethylene glycol, propylene glycol, 1,3-butylene glycol, and glycerin Monohydric alcohols; esters such as ethyl acetate, butyl acetate, methyl propionate and glyceryl trioctanoate; ketones such as acetone and methyl ethyl ketone; ethers such as ethyl ether and isopropyl ether; carbonization such as n-hexane, toluene and chloroform Examples thereof include hydrogen-based solvents, which are used alone or in combination of two or more.
In addition, from the viewpoint of the fibroblast activation action or collagen production promotion action of the obtained extract, in the present invention, among these solvents, those having a particularly high polarity are preferably used. Furthermore, it is preferable to use one kind of single solvent or two or more kinds of mixed solvents selected from water, lower alcohols and polyhydric alcohols from the viewpoint that they can be widely applied to cosmetics. Is most preferably used alone.
混合溶媒を用いる場合の混合比は、例えば水とエチルアルコールとの混合溶媒であれば、容量比(以下同じ)で1:1〜25:1、水とグリセリンとの混合溶媒であれば1:1〜20:1、又水と1,3−ブチレングリコールとの混合溶媒であれば、1:1〜20:1の範囲とすることが好ましい。 The mixing ratio in the case of using a mixed solvent is, for example, 1: 1 to 25: 1 by volume ratio (hereinafter the same) if the mixed solvent is water and ethyl alcohol, and 1: if the mixed solvent is water and glycerin. In the case of a mixed solvent of 1 to 20: 1, or water and 1,3-butylene glycol, it is preferably in the range of 1: 1 to 20: 1.
本発明の抽出エキスの調製に際して、抽出液のpHは5〜9の範囲に保持されることが好ましく、かかる意味で、必要ならば上記の抽出溶媒に、水酸化ナトリウム、炭酸ナトリウム、水酸化カリウム、アルギニンなどのアルカリ性調整剤や、クエン酸、塩酸、リン酸、硫酸などの酸性調整剤等を配合し、所望のpHとなるように調整してもよい。 In the preparation of the extract of the present invention, the pH of the extract is preferably maintained in the range of 5 to 9. In this sense, if necessary, the above extraction solvent may contain sodium hydroxide, sodium carbonate, potassium hydroxide. Alternatively, an alkaline adjusting agent such as arginine, an acidic adjusting agent such as citric acid, hydrochloric acid, phosphoric acid, sulfuric acid, or the like may be blended to adjust to a desired pH.
又、抽出温度、時間等の抽出条件は、用いる溶媒の種類、抽出方法等によっても異なるが、例えば浸漬法の場合であれば、抽出温度は、一般に1〜100℃、好ましくは30〜80℃の範囲であり、又抽出時間は、0.1〜24時間程度、特に0.5〜3時間程度が好適である。 Extraction conditions such as extraction temperature and time vary depending on the type of solvent used, the extraction method, and the like. For example, in the case of the immersion method, the extraction temperature is generally 1 to 100 ° C., preferably 30 to 80 ° C. In addition, the extraction time is preferably about 0.1 to 24 hours, particularly about 0.5 to 3 hours.
以上の抽出処理が終わったならば、ろ過、遠心分離などの固液分離手段を施して液相を分取し、一般にはそのpHを化粧料配合成分として好ましい範囲である4〜8に調整した上、これをそのまま、もしくは希釈或いは減圧濃縮等により適宜の濃度に調整して化粧料に配合する。又必要ならば、この液相をスプレードライ法、凍結乾燥法など常法に従って粉末化して化粧料に配合してもよい。さらに場合によっては、上記の固液分離手段を施す前の抽出原液を用いることもできる。 When the above extraction process is completed, the liquid phase is separated by applying solid-liquid separation means such as filtration and centrifugation, and the pH is generally adjusted to 4 to 8 which is a preferable range as a cosmetic ingredient. In addition, it is blended in cosmetics as it is or after adjusting to an appropriate concentration by dilution or vacuum concentration. If necessary, this liquid phase may be pulverized according to a conventional method such as a spray drying method or a freeze drying method and then blended into a cosmetic. Further, depending on the case, an extraction stock solution before applying the above-described solid-liquid separation means can be used.
発芽玄米の糠或いはそのエキスに酵素分解処理を施して酵素分解物を調製する場合、酵素としては、アクチナーゼ、パパインなどの蛋白分解酵素、グルコアミラーゼ、α-アミラーゼなどの澱粉分解酵素、セルラーゼ、ヘミセルラーゼ、ペクチナーゼなどの繊維素分解酵素及びリパーゼなどの脂肪分解酵素から選ばれた1種又は2種以上が用いられ、特にそれら4種の酵素群からそれぞれ選ばれた1種又は2種以上の酵素を組み合わせ用いることが好ましい。 In the case of preparing an enzymatic degradation product by subjecting germinated brown rice bran or its extract to enzymatic degradation, enzymes include proteolytic enzymes such as actinase and papain, starch degrading enzymes such as glucoamylase and α-amylase, cellulase, hemi One or more selected from fibrinolytic enzymes such as cellulase and pectinase and lipolytic enzymes such as lipase are used, and in particular one or more enzymes selected from these four enzyme groups, respectively. Are preferably used in combination.
それらの酵素による発芽玄米の糠或いはそのエキスの酵素分解処理は、被処理物として糠それ自体或いはエキス粉末を用いる場合であれば、それらを水或いは水と低級アルコールもしくは多価アルコールとの混液などの媒体、好適には水に懸濁或いは溶解した上、又エキス溶液を用いる場合であれば、これをそのままか、もしくは必要に応じて濃度調整等を施した上、これに酵素を添加し、酵素の至適温度付近に1〜24時間保持することによって行われる。
この場合、エキス溶液の調製に用いた抽出溶媒が、酵素反応の妨げとなる恐れのあるときには、該溶媒を一旦留去した上、ここに得られるエキス粉末を好ましくは水に再溶解或いは分散させて酵素処理を行うようにする。
酵素の添加量は、被処理物として糠それ自体を用いる場合であれば、その固形分に対して、合計で0.01〜10重量%、好ましくは0.1〜5重量%の範囲であり、又糠のエキスを用いる場合は、同じく固形分に対して合計で0.001〜5重量%、好ましくは0.01〜2重量%の範囲である。
Enzymatic degradation treatment of germinated brown rice bran or its extract with those enzymes, if the bran itself or extract powder is used as the object to be treated, such as water or a mixture of water and lower alcohol or polyhydric alcohol, etc. Medium, preferably suspended or dissolved in water, and if an extract solution is used, it is used as it is, or after adjusting the concentration if necessary, an enzyme is added thereto, It is carried out by keeping the temperature around the optimum temperature of the enzyme for 1 to 24 hours.
In this case, if the extraction solvent used to prepare the extract solution may interfere with the enzyme reaction, the solvent is once distilled off, and the extract powder obtained here is preferably redissolved or dispersed in water. Enzyme treatment.
The amount of the enzyme added is in the range of 0.01 to 10% by weight in total, preferably 0.1 to 5% by weight, based on the solid content, when cocoon itself is used as an object to be treated. Moreover, when using the extract of persimmon, it is similarly 0.001-5 weight% in total with respect to solid content, Preferably it is the range of 0.01-2 weight%.
以上の酵素分解処理が終わったならば、処理液に加熱処理を施して酵素を失活させた後、ここに得られる液をそのまま、もしくはろ過、遠心分離などによって液相を分取し、さらに必要ならばpH調整、濃度調整或いは粉末化処理等を施した上、化粧料の配合原料として供する。 When the above enzymatic decomposition treatment is completed, the treatment liquid is subjected to a heat treatment to deactivate the enzyme, and then the liquid obtained here is collected as it is or by filtration, centrifugation, etc. If necessary, after pH adjustment, concentration adjustment, or powdering treatment, etc., it is used as a raw material for cosmetics.
一方、発芽玄米の糠或いはそのエキスの発酵処理は、例えば以下のようにして行われる。
即ち、まず被発酵物を媒体に溶解もしくは懸濁させた発酵処理液を調製する、この場合、被発酵物として糠それ自体もしくはエキス粉末を用いるのであれば、酵素分解処理の場合と同様に、それらを水、水/低級アルコール混液或いは水/多価アルコール混液などの媒体、好適には水に懸濁或いは溶解して発酵処理液とする。 一方、エキス溶液を発酵する場合であれば、これをそのまま、もしくは必要ならば濃度調整や溶媒置換等を行って、発酵処理液とすればよい。
On the other hand, the fermentation treatment of germinated brown rice bran or its extract is performed, for example, as follows.
That is, firstly, a fermented solution is prepared by dissolving or suspending the fermented material in the medium. In this case, if the persimmon itself or the extract powder is used as the fermented product, as in the case of the enzymatic decomposition treatment, They are suspended or dissolved in a medium such as water, a water / lower alcohol mixture or a water / polyhydric alcohol mixture, preferably water, to obtain a fermentation treatment solution. On the other hand, if the extract solution is to be fermented, it may be used as it is, or if necessary, by adjusting the concentration, replacing the solvent, etc. to obtain a fermentation treatment solution.
次に、この発酵処理液に、発酵に先立って殺菌処理を施し、発酵の障害となる雑菌を除去する。
この雑菌の除去方法としては、発酵処理液を加熱処理する加熱殺菌法を用いるのが一般的であるが、これに代えて、発酵処理液自体を元々無菌状態のものとして調製する方法、例えば発芽玄米の糠それ自体を発酵する場合であれば、糠を予め殺菌エタノールで殺菌した後、無菌水等の無菌媒体に懸濁する方法を用いるようにしてもよい。
加熱殺菌処理としては、発酵処理液を120〜130℃で10〜20分間加熱するオートクレーブ殺菌法や、80〜90℃に60〜120分間保持することを1日1回2〜3日間繰り返す間断殺菌法といった方法が一般に用いられる。
Next, this fermentation treatment liquid is subjected to a sterilization treatment prior to fermentation to remove various germs that hinder fermentation.
As a method for removing this germ, it is common to use a heat sterilization method in which the fermentation treatment liquid is heat-treated, but instead, a method of preparing the fermentation treatment liquid itself as originally sterile, for example, germination If the brown rice bran itself is to be fermented, a method may be used in which the bran is sterilized in advance with sterilized ethanol and then suspended in a sterile medium such as sterile water.
As the heat sterilization treatment, the autoclave sterilization method in which the fermentation treatment solution is heated at 120 to 130 ° C. for 10 to 20 minutes, or the intermittent sterilization of holding at 80 to 90 ° C. for 60 to 120 minutes is repeated once a day for 2 to 3 days. A method such as the method is generally used.
次に、この発酵処理液を発酵タンクに入れ、菌を植菌して発酵を行わせしめる。菌としては、例えば乳酸菌、麹菌、酵母、納豆菌、テンペ菌などから選ばれた1種又は2種以上の菌が用いられる。植菌量は、発酵処理液に対して一般に107〜108/mLの範囲である。 Next, this fermentation treatment liquid is put into a fermentation tank, inoculated with bacteria and fermented. As the fungus, for example, one or two or more fungi selected from lactic acid bacteria, koji molds, yeasts, natto fungi, tempeh fungi and the like are used. The amount of inoculation is generally in the range of 10 7 to 10 8 / mL with respect to the fermentation treatment solution.
発酵に用いる乳酸菌としては、例えばラクトバシルス プランタラム(Lactobacillus plantarum)、ラクトバシルス ブレビス(L. brevis)、ラクトバシルス カゼイ(L. casei)等のラクトバシルス(Lactobacillus)属の乳酸菌;カルノバクテリウム ディバージェンス(Carnobacterium divergens)、カルノバクテリウム ピシコーラ(C. piscicola)等のカルノバクテリウム(Carnobacterium)属の乳酸菌;ロイコノストック メセンテロイズ(Leuconostoc mesenteroides)、ロイコノストック シトレウム(L. citreum)等のロイコノストック(Leuconostoc)属の乳酸菌;ストレブトコッカス フェーカリス(Streptococcus faecalis)、ストレブトコッカス ピオジェネス(S. pyogenes)等のストレブトコッカス(Streptococcus)属の乳酸菌;エンテロコッカス・カゼリフラバス(Enterococcus caseliflavus)、エンテロコッカス サルフレウス(E. sulfreus)等のエンテロコッカス(Enterococcus)属の乳酸菌;ラクトコッカス・プランタラム(Lactococcus plantarum)、ラクトコッカス ラフィノラクティス(L. rafinolactis)等のラクトコッカス(Lactococcus)属の乳酸菌;ヴェイセラ コンフューザ(Weissella confusa)、ヴェイセラ カンドゥレリ(W. kandleri)等のヴェイセラ(Weissella)属の乳酸菌;アトポビウム ミニュタム(Atopobium minutum)、アトポビウム パービュラス(A. parvulus)等のアトポビウム(Atopobium)属の乳酸菌;バゴコッカス フルビアリス(Vagococcus fluvialis)、バゴコッカス サーモニナラム(V. salmoninarum)等のバゴコッカス(Vagococcus)属の乳酸菌;ペディオコッカス ダムノサス(Pediococcus damnosus)、ペディオコッカス ペントサセウス(P. pentosaceus)等のペディオコッカス(Pediococcus)属の乳酸菌等が挙げられるが、それら乳酸菌のうちでも、得られる発酵物の作用効果の観点と取り扱いのし易さの点から、ラクトバチルス プランタラム(Lactobacillus plantarum)の使用が好ましい。 Examples of lactic acid bacteria used for fermentation include Lactobacillus plantarum, L. brevis, Lactobacillus Lactobacillus lactic acid bacteria such as Lactobacillus casei; Carnobacterium divergens ), Lactic acid bacteria of the genus Carnobacterium such as C. piscicola; Leuconostoc genus such as Leuconostoc mesenteroides and L. citreum Lactic acid bacteria; Streptococcus faecalis, Streptococcus pyogenes, and other Streptococcus lactic acid bacteria; Enterococcus caseliflavus, Enterococcus caseliflavus, Ento Lactococcus genus Enterococcus such as E. sulfreus; Lactococcus plantarum Lactococcus lactic acid bacteria such as Lactococcus plantarum Lactococcus lactic acid bacteria Weissella confusa, lactic acid bacteria of the genus Weissella (W. kandleri), etc .; lactic acid bacteria of the genus Atopobium (Atopobium minutum), Atopobium (A. parvulus), etc .; Vagocovia cc ), Lactic acid bacteria of the genus Vagococcus (V. salmoninarum); Pediococcus damnosus, pediococcus Pedosaceus (P. pentosaceus), etc. Among these lactic acid bacteria, the use of Lactobacillus plantarum is preferable from the viewpoint of the action effect of the obtained fermented product and the ease of handling. .
発酵に用いる麹菌としては、例えばアスペルギルス・オリゼー(Aspergillus oryzae)、アスペルギルス・フラバス(Aspergillus flavus)アスペルギルス・ポリオキソジェネス(Aspergillus polyoxogenes)、アスペルギルス・ソーヤ(Aspergillus sojae)等の黄麹菌、アスペルギルス・アワモリ(Aspergillus awamori)、アスペルギルス・カワウチ(Aspergillus kawauchii)、アスペルギルス・ウサミ(Aspergillus usami)、アスペルギルス・ニガー(Aspergillus niger)等の黒麹菌、モナスカス・アンカ(Monascus anka)、モナスカス・ビロサス(monascus pilosus)等の紅麹菌など、いずれの麹菌でも使用可能であるが、中でも発酵液の色が薄いことや発酵臭が比較的少ないといった点で、アスペルギルス・オリゼー(Aspergillus oryzae)が最も好ましい。 As the koji mold used for fermentation, for example, Aspergillus oryzae, Aspergillus flavus, Aspergillus polyoxogenes, Aspergillus sojae, Aspergillus sojae, Aspergillus sperm awamori), Aspergillus kawauchii, Aspergillus usami, Aspergillus niger and other black koji molds, Monascus anka, Monascus pilosus, etc. Any Aspergillus oryzae can be used, but among them, Aspergillus oryzae is most preferable because the color of the fermentation broth is light and the fermentation odor is relatively small.
発酵に用いる酵母としては、例えばサッカロミセス・セレビシエ(Saccharomy
ces cerevisiae)、サッカロミセス・アワモリ(Saccharomyces awamori)、サッカロミセス・チェバリエリ(Saccharomyces chevalieri)、サッカロミセス・カールスバージェンシス(Saccharomyces carlsbergensis)、サッカロミセス・バヨナス(Saccharomyces bayonus)等のサッカロミセス属の酵母、トルラスポラ・デルブルエキ(Torulaspora delbruekii)、トルラスポラ・ファーメンタチ(Torulaspora fermentati)、トルラスポラ・ロゼィ(Torulaspora rosei)等のトルラスポラ属の酵母、ジゴサッカロミセス・ローキシ(Zygosaccharomyces rouxii)、ジゴサッカロミセス・ソーヤ(Zygosaccharomyces soya)ジゴサッカロミセス・サケ(Zygosaccharomyces sake)、ジゴサッカロミセス・ミソ(Zygosaccharomyces miso)、ジゴサッカロミセス・ラクティス(Zygosaccharomyces lactis)等のジゴサッカロミセス属の酵母、カンディダ・ベルサチリス(Candida versatilis)、カンディダ・エチェリシィ(Candida etchellsii)、カンディダ・ケフィール(Candida kefyr)、カンディダ・サケ(Candida sake)、カンディダ・スコッティ(Candida scottii)等のカンディダ属の酵母など、いずれの酵母でも使用可能であるが、中でも食品に最も広く利用され、発酵力が強いといった点で、サッカロミセス・セレビシエ(Saccharomyces cerevisiae)が最も好ましい。
Examples of yeast used for fermentation include Saccharomyces cerevisiae (Saccharomy
ces cerevisiae), Saccharomyces awamori, Saccharomyces chevalieri, Saccharomyces carlsbergensis, Saccharomyces baorus, Saccharomyces baorus, etc. delbruekii), Torulaspora fermentati, Torulaspora rosei, and other yeasts of the genus Torlaspora; Zygosaccharomyces rouxii; , Yeasts belonging to the genus Digosaccharomyces such as Zygosaccharomyces miso and Zygosaccharomyces lactis Any yeast, including Candida versatilis, Candida etchellsii, Candida kefyr, Candida sake, Candida scottii, and other Candida scottii yeasts However, Saccharomyces cerevisiae is most preferable because it is most widely used for foods and has a strong fermenting power.
発酵に用いる納豆菌としては、例えばバシルス・ナットー(Bacillus natto)、バシルス・サブチルス(Bacillus subtilis)、バシルス・サーキュランス(Bacillus circulans)等のバシルス属の細菌が使用可能であるが、中でも食品に広く使用されており、安全性が高い点で、バシルス・ナットー(Bacillus natto)が最も好ましい。 As Bacillus natto used for fermentation, for example, bacteria of the genus Bacillus such as Bacillus natto, Bacillus subtilis, Bacillus circulans, etc. can be used. Bacillus natto is most preferable because it is used and has high safety.
発酵に用いるテンペ菌としては、例えばリゾプス・アジゴスポラス(Rhizopus azygosporus)、リゾプス・ミクロスボラス チネンシス(Rhizopus microsporus chinensis)、リゾプス・ミクロスポラス オリゴスポラス(Rhizopus microsporus oligosporus)、リゾプス・ニベウス(Rhizopus niveus)、リゾプス・オリゼー(Rhizopus oryzae)等のリゾプス属の真菌(カビ)が使用可能であるが、中でもインドネシアをはじめ東南アジア地域で発酵食品に広く使用されており安全性が高い点で、リゾプス・ミクロスポラス オリゴスポラス(Rhizopus microsporus oligosporus)やリゾプス・オリゼー(Rhizopus oryzae)が最も好ましい。 Examples of tempeh bacteria used for fermentation include Rhizopus azygosporus, Rhizopus microsporus chinensis, Rhizopus microsporus oligosporus, Rhizopus microsporus oligosporus, Rhizopus microsporus oligosporus, (Rhizopus oryzae) and other fungi of the genus Rhizopus can be used. Among them, Rhizopus microsporus is widely used in fermented foods in Indonesia and other Southeast Asian regions. oligosporus) and Rhizopus oryzae are most preferred.
発酵温度は一般には5〜50℃の範囲であり、好ましくは乳酸菌、麹菌、納豆菌及びテンペ菌であれば、その生育至適温度である35〜40℃の範囲、酵母であれば同じく生育至適温度である25〜35℃の範囲である。発酵期間は、いずれの菌も、至適温度に於いて一般に3時間〜10日、好ましくは10時間〜3日の範囲である。 The fermentation temperature is generally in the range of 5 to 50 ° C., preferably in the range of 35 to 40 ° C., which is the optimal temperature for lactic acid bacteria, koji molds, natto and tempe bacteria, and in the case of yeast, It is the range of 25-35 degreeC which is suitable temperature. The fermentation period is generally in the range of 3 hours to 10 days, preferably 10 hours to 3 days, at any optimum temperature.
なお、以上の発酵処理を行うに当たって、発芽玄米の糠の成分が各菌の資化源としてより有効に利用されるようにするため、各菌の植菌前もしくは植菌と同時に前酵素を添加して、発芽玄米の糠或いはそのエキスに酵素による加水分解処理を施すことが好ましく、特に発芽玄米の糠それ自体を被発酵物とする場合には、かかる酵素処理を併用することが有効である。
この処理に用いる酵素種及び処理条件は、前記した酵素分解処理の場合と同様であって何ら差し支えない。
In addition, in performing the above fermentation treatment, pre-enzyme is added before or simultaneously with the inoculation of each fungus so that the germinated brown rice bran component can be used more effectively as an assimilation source of each fungus. In addition, it is preferable to subject the germinated brown rice bran or its extract to an enzymatic hydrolysis treatment, and in particular, when the germinated brown rice bran itself is to be fermented, it is effective to use such enzyme treatment in combination. .
The enzyme species and treatment conditions used for this treatment are the same as in the case of the above-described enzymatic decomposition treatment, and there is no problem.
以上の発酵処理が終わったならば、各菌の殺菌と酵素処理を併用した場合であれば酵素の失活を兼ねて、発酵液に70〜100℃で10〜120分程度の加熱殺菌処理を施した後、これをそのまま、或いは一般且つ好適にはろ過或いは遠心分離などの固液分離手段によって液相を分取し、必要ならばpHを通常の化粧料のpH領域であるpH6〜8に調整し、さらに必要ならば希釈もしくは濃縮によって適宜の濃度とした上、化粧料の配合原料として供する。又、場合によっては、固液分離後の液相をスプレードライ法、凍結乾燥法など常法に従って粉末化した上化粧料に配合してもよい。 If the above fermentation treatment is completed, if the sterilization of each bacterium and the enzyme treatment are used in combination, the enzyme is deactivated and the fermentation broth is subjected to a heat sterilization treatment at 70 to 100 ° C. for about 10 to 120 minutes. After application, the liquid phase is separated as it is, or generally and preferably by solid-liquid separation means such as filtration or centrifugation, and if necessary, the pH is adjusted to pH 6-8, which is the pH range of ordinary cosmetics. It is adjusted and, if necessary, adjusted to an appropriate concentration by dilution or concentration, and then used as a cosmetic raw material. In some cases, the liquid phase after solid-liquid separation may be blended into a cosmetic after being powdered according to a conventional method such as spray drying or freeze drying.
本発明の発芽玄米の糠、そのエキス或いはそれらの酵素分解物もしくは発酵物を配合してなる化粧料としては、例えば乳液、クリーム、ローション、エッセンス、パック、洗顔料などの基礎化粧料、口紅、ファンデーション、リキッドファンデーション、メイクアッププレスパウダーなどのメイクアップ化粧料、ヘアーシャンプー、ヘアーリンス、ヘアートリートメント、コンディショナー、染毛料、整髪料などの頭髪化粧料、洗顔料、ボディーシャンプー、石けんなどの清浄用化粧料、さらには浴剤等が挙げられる。又、貼付剤の形とすることもできる。 Examples of cosmetics comprising the germinated brown rice bran of the present invention, its extract, or their enzymatic degradation product or fermented product include basic cosmetics such as emulsions, creams, lotions, essences, packs, facial cleansers, lipsticks, Makeup cosmetics such as foundations, liquid foundations, makeup press powders, hair shampoos, hair rinses, hair treatments, conditioners, hair dyes, hair conditioners, and other hair cosmetics, facial cleansers, body shampoos, soaps, etc. And bath additives. It can also be in the form of a patch.
本発明の化粧料中に於ける発芽玄米の糠、そのエキス或いはそれらの酵素分解物もしくは発酵物の配合量は、固形分として、例えば基礎化粧料については、一般に0.001〜5重量%、好ましくは0.01〜3重量%の範囲、メイクアップ化粧料ついては、一般に0.001〜5重量%、好ましくは0.01〜2重量%の範囲、頭髪化粧料については、一般に0.001〜10重量%、好ましくは0.01〜5重量%の範囲、又清浄用化粧料については、一般に0.001〜10重量%、好ましくは0.01〜5重量%の範囲である。 The blended amount of germinated brown rice bran, its extract or enzymatic degradation product or fermented product thereof in the cosmetic composition of the present invention is generally 0.001 to 5% by weight, for example, for basic cosmetics, Preferably in the range of 0.01 to 3% by weight, for makeup cosmetics generally in the range of 0.001 to 5% by weight, preferably in the range of 0.01 to 2% by weight, for hair cosmetics in general 0.001 to In the range of 10% by weight, preferably 0.01-5% by weight, and for cosmetics for cleaning, it is generally in the range of 0.001-10% by weight, preferably 0.01-5% by weight.
本発明の化粧料には、上記の必須成分のほかに、通常化粧料に用いられる成分、例えば油性成分、界面活性剤、保湿剤、増粘剤、防腐・殺菌剤、粉体成分、紫外線吸収剤、抗酸化剤、色素、香料等を必要に応じて適宜配合することができる。
又、本発明の必須成分の有効性や特長を損なわない限り、他の生理活性成分を併せ配合することも何ら差し支えない。
In addition to the above essential components, the cosmetics of the present invention include components usually used in cosmetics, such as oily components, surfactants, moisturizers, thickeners, antiseptic / disinfectants, powder components, ultraviolet absorption. Agents, antioxidants, pigments, fragrances and the like can be appropriately blended as necessary.
Moreover, as long as the effectiveness and the features of the essential components of the present invention are not impaired, other physiologically active components may be blended together.
ここで、油性成分としては、例えばオリーブ油、ホホバ油、ヒマシ油、大豆油、米油、米胚芽油、ヤシ油、パーム油、カカオ油、メドウフォーム油、シアーバター、ティーツリー油、アボガド油、マカデミアナッツ油、植物由来スクワランなどの植物由来の油脂類;ミンク油、タートル油などの動物由来の油脂類;ミツロウ、カルナウバロウ、ライスワックス、ラノリンなどのロウ類;流動パラフィン、ワセリン、パラフィンワックス、スクワランなどの炭化水素類;ミリスチン酸、パルミチン酸、ステアリン酸、オレイン酸、イソステアリン酸、cis−11−エイコセン酸などの脂肪酸類;ラウリルアルコール、セタノール、ステアリルアルコールなどの高級アルコール類;ミリスチン酸イソプロピル、パルミチン酸イソプロピル、オレイン酸ブチル、2−エチルヘキシルグリセライド、高級脂肪酸オクチルドデシル(ステアリン酸オクチルドデシル等)などの合成エステル類及び合成トリグリセライド類等が挙げられる。 Here, as the oil component, for example, olive oil, jojoba oil, castor oil, soybean oil, rice oil, rice germ oil, palm oil, palm oil, cacao oil, meadow foam oil, sheer butter, tea tree oil, avocado oil, Oils derived from plants such as macadamia nut oil and plant-derived squalane; Fats derived from animals such as mink oil and turtle oil; waxes such as beeswax, carnauba wax, rice wax, lanolin; liquid paraffin, petrolatum, paraffin wax, squalane, etc. Hydrocarbons; fatty acids such as myristic acid, palmitic acid, stearic acid, oleic acid, isostearic acid, cis-11-eicosenoic acid; higher alcohols such as lauryl alcohol, cetanol, stearyl alcohol; isopropyl myristate, palmitic acid Isopropyl, me Butyl phosphate, 2-ethylhexyl glycerides, higher fatty acid octyldodecyl (octyl stearate dodecyl and the like), and the synthetic esters and synthetic triglycerides such like.
界面活性剤としては,例えばポリオキシエチレンアルキルエーテル、ポリオキシエチレン脂肪酸エステル、ポリオキシエチレンソルビタン脂肪酸エステル、グリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル、ポリオキシエチレングリセリン脂肪酸エステル、ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレンソルビトール脂肪酸エステルなどの非イオン界面活性剤;脂肪酸塩、アルキル硫酸塩、アルキルベンゼンスルホン酸塩、ポリオキシエチレンアルキルエーテル硫酸塩、ポリオキシエチレン脂肪酸アミン硫酸塩、ポリオキシエチレンアルキルフェニルエーテル硫酸塩、ポリオキシエチレンアルキルエーテル燐酸塩、α−スルホン化脂肪酸アルキルエステル塩、ポリオキシエチレンアルキルフェニルエーテル燐酸塩などのアニオン界面活性剤;第四級アンモニウム塩、第一級〜第三級脂肪酸アミン塩、トリアルキルベンジルアンモニウム塩、アルキルピリジニウム塩、2−アルキル−1−アルキル−1−ヒドロキシエチルイミダゾリニウム塩、N,N−ジアルキルモルフォルニウム塩、ポリエチレンポリアミン脂肪酸アミド塩などのカチオン界面活性剤;N,N−ジメチル−N−アルキル−N−カルボキシメチルアンモニオベタイン、N,N,N−トリアルキル−N−アルキレンアンモニオカルボキシベタイン、N−アシルアミドプロピル−N′,N′−ジメチル−N′−β−ヒドロキシプロピルアンモニオスルホベタインなどの両性界面活性剤等を使用することができる。
又、乳化剤乃至乳化助剤として、酵素処理ステビアなどのステビア誘導体、レシチン及びその誘導体、乳酸菌発酵米、乳酸菌発酵発芽米、乳酸菌発酵穀類(麦類、豆類、雑穀など)、ジュアゼイロ(Zizyphus juazeiro:Rhamnaceae)抽出物等を配合することもできる。
Examples of the surfactant include polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene hydrogenated castor oil, polyoxyethylene Nonionic surfactants such as oxyethylene sorbitol fatty acid esters; fatty acid salts, alkyl sulfates, alkylbenzene sulfonates, polyoxyethylene alkyl ether sulfates, polyoxyethylene fatty acid amine sulfates, polyoxyethylene alkyl phenyl ether sulfates, Polyoxyethylene alkyl ether phosphates, α-sulfonated fatty acid alkyl ester salts, polyoxyethylene alkyl phenyl ether phosphates, etc. ON surfactant: quaternary ammonium salt, primary to tertiary fatty acid amine salt, trialkylbenzylammonium salt, alkylpyridinium salt, 2-alkyl-1-alkyl-1-hydroxyethylimidazolinium salt, N N, N-dimethyl-N-alkyl-N-carboxymethylammoniobetaine, N, N, N-trialkyl-N-, N, N-dimethyl-N-alkyl-N-carboxymethylammoniobetaine Amphoteric surfactants such as alkylene ammoniocarboxybetaine and N-acylamidopropyl-N ′, N′-dimethyl-N′-β-hydroxypropylammoniosulfobetaine can be used.
In addition, as emulsifiers or emulsifiers, stevia derivatives such as enzyme-treated stevia, lecithin and derivatives thereof, lactic acid bacteria fermented rice, lactic acid bacteria fermented germinated rice, lactic acid bacteria fermented cereals (wheat, beans, millet, etc.), juiziro (Rhamnaceae ) An extract or the like can also be blended.
保湿剤としては、例えばグリセリン、プロピレングリコール、ジプロピレングリコール、1,3−ブチレングリコール、ポリエチレングリコール、ソルビトール、キシリトール、ピロリドンカルボン酸ナトリウム、N−(3,4,5,6−テトラヒドロキシ−2−オキソヘキシル)ピログルタミン酸等があり、さらにトレハロース等の糖類、乳酸菌発酵米、ムコポリサッカライド(例えば、ヒアルロン酸及びその誘導体、コンドロイチン及びその誘導体、ヘパリン及びその誘導体など)、エラスチン及びその誘導体、コラーゲン及びその誘導体、加水分解シルク蛋白質、NMF関連物質、乳酸、尿素、高級脂肪酸オクチルドデシル、フィトステロール、大豆リン脂質、イソステアリン酸コレステリル、海藻抽出物、魚介類由来コラーゲン及びその誘導体、各種アミノ酸及びそれらの誘導体(例えばトリメチルグリシンなど)、ビャッキュウ抽出物、豆乳発酵液、納豆エキス、米由来抽出物及びその発酵物等が挙げられる。 Examples of the humectant include glycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, polyethylene glycol, sorbitol, xylitol, sodium pyrrolidonecarboxylate, N- (3,4,5,6-tetrahydroxy-2- Oxohexyl) pyroglutamic acid, etc., sugars such as trehalose, lactic acid bacteria fermented rice, mucopolysaccharides (for example, hyaluronic acid and its derivatives, chondroitin and its derivatives, heparin and its derivatives, etc.), elastin and its derivatives, collagen and Its derivatives, hydrolyzed silk protein, NMF related substances, lactic acid, urea, higher fatty acid octyldodecyl, phytosterol, soybean phospholipid, cholesteryl isostearate, seaweed extract, seafood-derived collagen and Derivatives, various amino acids and their derivatives (such as trimethyl glycine, etc.), Byakkyuu extract, soybean milk fermented liquor, natto extract, rice-derived extract and fermented, and the like.
増粘剤としては、例えばアルギン酸、寒天、カラギーナン、フコイダン等の褐藻、緑藻或いは紅藻由来成分、ビャッキュウ抽出物、ペクチン、ローカストビーンガム、アロエ多糖体等の多糖類、キサンタンガム、トラガントガム、グアーガム等のガム類、カルボキシメチルセルロース、ヒドロキシエチルセルロース等のセルロース誘導体、ポリビニルアルコール、ポリビニルピロリドン、カルボキシビニルポリマー、アクリル酸・メタクリル酸共重合体等の合成高分子類;ヒアルロン酸及びその誘導体、ポリグルタミン酸及びその誘導体、グルコシルトレハロースと加水分解水添デンプンを主体とする糖化合物等が挙げられる。 Examples of thickeners include, for example, brown algae such as alginic acid, agar, carrageenan, fucoidan, green algae or red algae-derived components, beech extract, pectin, locust bean gum, polysaccharides such as aloe polysaccharide, xanthan gum, tragacanth gum, guar gum, etc. Synthetic polymers such as gums, cellulose derivatives such as carboxymethylcellulose, hydroxyethylcellulose, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, acrylic acid / methacrylic acid copolymer; hyaluronic acid and its derivatives, polyglutamic acid and its derivatives, Examples thereof include sugar compounds mainly composed of glucosyl trehalose and hydrolyzed hydrogenated starch.
防腐・殺菌剤としては、例えば尿素;パラオキシ安息香酸メチル、パラオキシ安息香酸エチル、パラオキシ安息香酸プロピル、パラオキシ安息香酸ブチルなどのパラオキシ安息香酸エステル類;フェノキシエタノール、ジクロロフェン、ヘキサクロロフェン、塩酸クロルヘキシジン、塩化ベンザルコニウム、サリチル酸、エタノール、ウンデシレン酸、フェノール類、ジャーマル(イミダゾデイニールウレア)、1,2−ペンタンジオール、各種精油類、樹皮乾留物、プロポリスエキス、メチルイソチアゾリノン等がある。 Examples of the antiseptic / bactericidal agent include urea; paraoxybenzoates such as methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, and butyl paraoxybenzoate; phenoxyethanol, dichlorophene, hexachlorophene, chlorhexidine hydrochloride, benzaza chloride Examples thereof include Luconium, Salicylic acid, Ethanol, Undecylenic acid, Phenols, Jamal (Imidazodenyl urea), 1,2-pentanediol, various essential oils, bark dry product, propolis extract, methylisothiazolinone.
粉体成分としては、例えばセリサイト、酸化チタン、タルク、カオリン、ベントナイト、酸化亜鉛、炭酸マグネシウム、酸化マグネシウム、酸化ジルコニウム、硫酸バリウム、無水ケイ酸、雲母、6−又は12−ナイロンパウダー、ポリエチレンパウダー、シルクパウダー、セルロース系パウダー、穀類(米、麦、トウモロコシ、キビなど)のパウダー、豆類(大豆、小豆など)のパウダー等がある。 Examples of the powder component include sericite, titanium oxide, talc, kaolin, bentonite, zinc oxide, magnesium carbonate, magnesium oxide, zirconium oxide, barium sulfate, silicic anhydride, mica, 6- or 12-nylon powder, polyethylene powder. , Silk powder, cellulosic powder, grains (rice, wheat, corn, millet, etc.) powder, beans (soybean, red beans, etc.) powder, etc.
紫外線吸収剤としては、例えばパラアミノ安息香酸エチル、パラジメチルアミノ安息香酸エチルヘキシル、サリチル酸アミル及びその誘導体、パラメトキシ桂皮酸2−エチルヘキシル、桂皮酸オクチル、オキシベンゾン、2,4−ジヒドロキシベンゾフェノン、2−ヒドロキシ−4−メトキシベンゾフェノン−5−スルホン酸塩、4−ターシャリーブチル−4−メトキシベンゾイルメタン、2−(2−ヒドロキシ−5−メチルフェニル)ベンゾトリアゾール、ウロカニン酸、ウロカニン酸エチル、アロエ抽出物等がある。 Examples of the ultraviolet absorber include ethyl paraaminobenzoate, ethylhexyl paradimethylaminobenzoate, amyl salicylate and derivatives thereof, 2-ethylhexyl paramethoxycinnamate, octyl cinnamate, oxybenzone, 2,4-dihydroxybenzophenone, 2-hydroxy-4 -Methoxybenzophenone-5-sulfonate, 4-tertiarybutyl-4-methoxybenzoylmethane, 2- (2-hydroxy-5-methylphenyl) benzotriazole, urocanic acid, ethyl urocanate, aloe extract, etc. .
抗酸化剤としては、例えばブチルヒドロキシアニソール、ブチルヒドロキシトルエン、没食子酸プロピル、ビタミンE及びその誘導体、ユビデカキノン(ユビキノン)、ルチン、ルチングルコシド、白芥子抽出物、イネ抽出物、ムラサキシキブ抽出物、シラカバ抽出物、ハマメリス抽出物、ウーロン茶抽出物、黒豆加水分解抽出液、ハゴロモグサ抽出液等がある。 Antioxidants include, for example, butylhydroxyanisole, butylhydroxytoluene, propyl gallate, vitamin E and its derivatives, ubidecaquinone (ubiquinone), rutin, rutin glucoside, white coconut extract, rice extract, murasakikibu extract, birch extract Products, hamamelis extract, oolong tea extract, black bean hydrolyzed extract, hagoromogusa extract and the like.
生理活性成分としては、例えば美白成分として、t−シクロアミノ酸誘導体、コウジ酸及びその誘導体、アスコルビン酸及びその誘導体、ハイドロキノン誘導体、エラグ酸及びその誘導体、レゾルシノール誘導体、ソウハクヒ抽出物、ユキノシタ抽出物、米糠抽出物、米糠抽出物加水分解物、乳酸菌発酵米、乳酸菌発酵発芽米、乳酸菌発酵穀類(麦類、豆類、雑穀類)、白芥子加水分解抽出物、ムラサキシキブ抽出物、ハスの実発酵物、党参抽出物、パンダヌス・アマリリフォリウス(Pandanus amaryllifolius Roxb.)抽出物、アルカンジェリシア・フラバ(Arcangelicia flava Merrilli)抽出物、カミツレ抽出物(商品名:カモミラET)、ジンコウ抽出物、ハマメリス抽出物、イタドリ抽出物、サワヒヨドリ抽出物、甘草抽出物、フキタンポポ抽出物、アルテア抽出物、ゲンノショウコ抽出物、ユキノシタ抽出物、ナツメ抽出物、シャクヤク抽出物、トウキ抽出物、モモ抽出物、柑橘類(例えばミカン、ユズ、ダイダイ、ザボンなど)の抽出物及びその単離物質(例えばナリルチン、ヘスペリジンなど)、緑藻類、紅藻類又は褐藻類の海藻の抽出物、アマモ等の海草の抽出物、リノール酸及びその誘導体もしくは加工物(例えばリポソーム化リノール酸など)、2,5−ジヒドロキシ安息香酸誘導体等が、又皮膚老化防止・美肌化成分として、動物又は魚由来のコラーゲン及びその誘導体、エラスチン及びその誘導体、ニコチン酸及びその誘導体、グリチルリチン酸及びその誘導体(ジカリウム塩等)、t−シクロアミノ酸誘導体、ビタミンA及びその誘導体、ビタミンE及びその誘導体、アラントイン、α−ヒドロキシ酸類、ジイソプロピルアミンジクロロアセテート、γ−アミノ−β−ヒドロキシ酪酸、コエンザイムQ−10、α−リポ酸、ゲンチアナエキス、甘草エキス、ハトムギエキス、カミツレエキス、ニンジンエキス、アロエエキスなどの生薬抽出エキス、米抽出物加水分解物、低アレルゲン米抽出物加水分解物、米糠抽出物加水分解物、米発酵エキス、緑藻類、紅藻類又は褐藻類の海藻の抽出物、アマモ等の海草の抽出物、ソウハクヒエキス、ジュアゼイロ(Zizyphus juazeiro)抽出物、ブナ抽出物、キダチアロエ抽出物、マンネンロウ抽出物、イチョウ抽出物、スギナ抽出物、ベニバナ抽出物、オタネニンジン抽出物、セイヨウニワトコ抽出物、ハゴロモグサ抽出物、レンゲ抽出物、マンゴー抽出物、チェリモヤ抽出物、マンゴスチン抽出物、タベブイア・インペチギノサ抽出物、柑橘類(例えばミカン、ユズ、ダイダイ、ザボンなど)の抽出物及びその単離物質(例えばナリルチン、ヘスペリジンなど)、酵母抽出物、卵殻膜抽出タンパク質、デオキシリボ核酸カリウム塩、ハス発酵液、紫蘭根抽出物、ムラサキシキブ抽出物、イネ抽出物、サンゴ草抽出物、花粉荷エキス、ユリ全草抽出物等がある。 Examples of physiologically active ingredients include whitening ingredients such as t-cycloamino acid derivatives, kojic acid and derivatives thereof, ascorbic acid and derivatives thereof, hydroquinone derivatives, ellagic acid and derivatives thereof, resorcinol derivatives, sucha akuhi extract, yukinoshita extract, rice bran Extract, rice bran extract hydrolyzate, lactic acid bacteria fermented rice, lactic acid bacteria fermented germinated rice, lactic acid bacteria fermented cereals (wheat, legumes, minor grains), white coconut hydrolyzed extract, murasakixikibu extract, lotus seed fermented product, party participation Extract, Pandanus amaryllifolius Roxb extract, Arcangelicia flava Merrilli extract, chamomile extract (trade name: Chamomile ET), ginger extract Japanese knotweed extract, Sahby foliage extract, licorice extract, dandelion extract, artea extract, genus shochu extract, yukinoshita extract, jujube extract, peonies extract, suzuki extract, peach extract, citrus (e.g. mandarin orange, citrus) , Daidai, pomelo, etc.) and its isolated substances (eg, nariltin, hesperidin, etc.), green algae, red algae or brown algae seaweed extracts, seaweed extracts such as sea eels, linoleic acid and its derivatives or processing Products (for example, liposomal linoleic acid), 2,5-dihydroxybenzoic acid derivatives, etc., and skin aging preventing / beautifying components such as collagen derived from animals or fish and derivatives thereof, elastin and derivatives thereof, nicotinic acid and derivatives thereof Derivatives, glycyrrhizic acid and its derivatives (dipotassium salts, etc.), t-cycloa Mino acid derivatives, vitamin A and derivatives thereof, vitamin E and derivatives thereof, allantoin, α-hydroxy acids, diisopropylamine dichloroacetate, γ-amino-β-hydroxybutyric acid, coenzyme Q-10, α-lipoic acid, gentian extract, Herbal extracts such as licorice extract, pearl barley extract, chamomile extract, carrot extract, aloe extract, rice extract hydrolyzate, low allergen rice extract hydrolysate, rice bran extract hydrolyzate, rice fermented extract, green algae, red Seaweed extract of algae or brown algae, seagrass extract such as sea cucumber, Sakuhakuhi extract, Zizyhus juazeiro extract, beech extract, Kidachi aloe extract, mannenrou extract, ginkgo extract, horsetail extract, safflower Extract, ginseng extract, sei Elderberry extract, Chrysalis extract, Astragalus extract, Mango extract, Cherimoya extract, Mangosteen extract, Tabebuia impetiginosa extract, citrus (eg, mandarin orange, yuzu, Daidai, pomelo etc.) extract and its isolated substance (E.g., nariltin, hesperidin, etc.), yeast extract, eggshell membrane extract protein, potassium deoxyribonucleic acid, lotus fermentation broth, purple orchid root extract, murasakikibu extract, rice extract, coral grass extract, pollen extract, lily whole There are herbal extracts.
上記のコウジ酸誘導体としては、例えばコウジ酸モノブチレート、コウジ酸モノカプレート、コウジ酸モノパルミテート、コウジ酸ジブチレートなどのコウジ酸エステル類、コウジ酸エーテル類、コウジ酸グルコシドなどのコウジ酸糖誘導体等が、アスコルビン酸誘導体としては、例えばL−アスコルビン酸−2−リン酸エステルナトリウム、L−アスコルビン酸−2−リン酸エステルマグネシウム、L−アスコルビン酸−2−硫酸エステルナトリウム、L−アスコルビン酸−2−硫酸エステルマグネシウムなどのアスコルビン酸エステル塩類、L−アスコルビン酸−2−グルコシド(2−O−α−D−グルコピラノシル−L−アスコルビン酸)、L−アスコルビン酸−5−グルコシド(5−O−α−D−グルコピラノシル−L−アスコルビン酸)などのアスコルビン酸糖誘導体、それらアスコルビン酸糖誘導体の6位アシル化物(アシル基は、ヘキサノイル基、オクタノイル基、デカノイル基など)、L−アスコルビン酸テトライソパルミチン酸エステル、L−アスコルビン酸テトララウリン酸エステルなどのL−アスコルビン酸テトラ脂肪酸エステル類、3−O−エチルアスコルビン酸、L−アスコルビン酸−2−リン酸−6−O−パルミテートナトリウム等が、ハイドロキノン誘導体としては、アルブチン(ハイドロキノン−β−D−グルコピラノシド)、α−アルブチン(ハイドロキノン−α−D−グルコピラノシド)等が、レゾルシノール誘導体としては、例えば4−n−ブチルレゾルシノール、4−イソアミルレゾルシノール等が、2,5−ジヒドロキシ安息香酸誘導体としては、例えば2,5−ジアセトキシ安息香酸、2−アセトキシ−5−ヒドロキシ安息香酸、2−ヒドロキシ−5−プロピオニルオキシ安息香酸等が、ニコチン酸誘導体としては、例えばニコチン酸アミド、ニコチン酸ベンジル等が、ビタミンE誘導体としては、例えばビタミンEニコチネート、ビタミンEリノレート、ビタミンEリン酸エステルナトリウム塩等が、α−ヒドロキシ酸としては、例えば乳酸、リンゴ酸、コハク酸、クエン酸、α−ヒドロキシオクタン酸等がある。 Examples of the kojic acid derivative include kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, kojic acid esters such as kojic acid dibutyrate, kojic acid sugar derivatives such as kojic acid ethers, and kojic acid glucoside. However, as the ascorbic acid derivatives, for example, L-ascorbic acid-2-phosphate sodium, L-ascorbic acid-2-phosphate magnesium, L-ascorbic acid-2-sulfate sodium, L-ascorbic acid-2 -Ascorbic acid ester salts such as magnesium sulfate, L-ascorbic acid-2-glucoside (2-O-α-D-glucopyranosyl-L-ascorbic acid), L-ascorbic acid-5-glucoside (5-O-α) -D-glucopyranosyl-L-ascorbine Acid) ascorbic acid sugar derivatives, acylated 6-positions of these ascorbic acid sugar derivatives (acyl groups are hexanoyl, octanoyl, decanoyl, etc.), L-ascorbic acid tetraisopalmitate, L-ascorbic acid tetra L-ascorbic acid tetrafatty acid esters such as lauric acid ester, 3-O-ethylascorbic acid, L-ascorbic acid-2-phosphate-6-O-palmitate sodium and the like are hydroquinone derivatives such as arbutin (hydroquinone). -Β-D-glucopyranoside), α-arbutin (hydroquinone-α-D-glucopyranoside) and the like, and as resorcinol derivatives, for example, 4-n-butylresorcinol, 4-isoamylresorcinol and the like are 2,5-dihydroxybenzoic acid. Derivatives and For example, 2,5-diacetoxybenzoic acid, 2-acetoxy-5-hydroxybenzoic acid, 2-hydroxy-5-propionyloxybenzoic acid, etc., and nicotinic acid derivatives include, for example, nicotinic acid amide, nicotinic acid benzyl, etc. However, examples of vitamin E derivatives include vitamin E nicotinate, vitamin E linoleate, and sodium salt of vitamin E phosphate. Examples of α-hydroxy acids include lactic acid, malic acid, succinic acid, citric acid, and α-hydroxyoctane. There are acids.
次に、製造例、試験例及び実施例(化粧料の処方例)を挙げて本発明をさらに具体的に説明するが、本発明はそれらに限定されるものではない。なお、以下に於いて、部はすべて重量部を、又%はすべて重量%を意味する。 Next, although a manufacture example, a test example, and an Example (formulation example of cosmetics) are given and this invention is demonstrated further more concretely, this invention is not limited to them. In the following, all parts are parts by weight, and all% are% by weight.
製造例1.発芽玄米の糠のエキスの調製
発芽玄米の糠100gに精製水1000gを混合し、50℃で3時間抽出を行った後ろ過し、淡褐色透明の発芽玄米の糠のエキス溶液323gを得た(固形分濃度1.52%)。
Production Example 1 Preparation of germinated brown rice bran extract 100 g of germinated brown rice bran was mixed with 1000 g of purified water, extracted at 50 ° C. for 3 hours, and then filtered to obtain 323 g of a light brown transparent germinated brown rice bran extract solution ( Solid content concentration 1.52%).
製造例2.発芽玄米の糠のエキスの調製
発芽玄米の糠330gに精製水1000gを混合し、30℃で24時間抽出を行った後ろ過し、淡褐色透明の抽出物溶液245gを得た(固形分濃度4.21%)。これを、固形分濃度が1.50%となるように精製水で希釈して、発芽玄米の糠のエキス溶液を得た。
Production Example 2 Preparation of Sprouted Brown Rice Bran Extract 1000 g of purified water was mixed with 330 g of germinated brown rice bran, extracted at 30 ° C. for 24 hours, and then filtered to obtain 245 g of a light brown transparent extract solution (solid content 4) .21%). This was diluted with purified water so that the solid content concentration would be 1.50% to obtain an extract solution of germinated brown rice bran.
製造例3.発芽玄米の糠のエキスの調製
発芽玄米の糠100gに精製水とエタノールの8:2(重量比)混液1000gを混合し、4℃で72時間抽出を行った後ろ過し、淡褐色透明の発芽玄米の糠のエキス溶液650gを得た(固形分濃度1.44%)。
Production Example 3 Preparation of germinated brown rice bran extract 100 g of germinated brown rice bran mixed with 1000 g of 8: 2 (weight ratio) mixture of purified water and ethanol, extracted at 4 ° C. for 72 hours, filtered, and germinated in a light brown transparent 650 g of brown rice bran extract solution was obtained (solids concentration 1.44%).
製造例4.発芽玄米の糠のエキスの調製
発芽玄米の糠200gに精製水と1,3‐ブチレングリコールの7:3(重量比)混液1200gを混合し、80℃で2時間抽出を行った後ろ過し、淡褐色透明の発芽玄米の糠のエキス溶液820gを得た(固形分濃度1.25%)。
Production Example 4 Preparation of germinated brown rice koji extract 200 g of germinated brown rice koji is mixed with 1200 g of a 7: 3 (weight ratio) mixture of purified water and 1,3-butylene glycol, filtered at 80 ° C. for 2 hours, filtered. 820 g of a light brown transparent germinated brown rice koji extract solution was obtained (solid content concentration 1.25%).
製造例5.発芽玄米の糠のエキスの調製
製造例1と同様にして調製した発芽玄米の糠のエキス溶液500gを凍結乾燥した後粉砕し、黄褐色の発芽玄米の糠のエキス粉末7.0gを得た。
Production Example 5 Preparation of germinated brown rice bran extract 500 g of a germinated brown rice bran extract solution prepared in the same manner as in Production Example 1 was lyophilized and pulverized to obtain 7.0 g of yellow brown germinated brown rice bran extract powder.
製造例6.発芽玄米の糠のエキスの酵素分解物溶液の調製
発芽玄米の糠100gに精製水1000gを混合し、50℃で3時間抽出を行った後ろ過し、発芽玄米の糠のエキス溶液340gを得た。この溶液に対して、0.5gのリパーゼを添加し、50℃で3時間加水分解処理を行い、次いで80℃で1時間加熱して酵素を失活させた後ろ過し、淡褐色透明の発芽玄米の糠エキスの酵素分解物溶液301gを得た(固形分濃度2.11%)。
Production Example 6 Preparation of Enzymatic Decomposition Solution of Germinated Brown Rice Koji Extract 100 g of Germinated Brown Rice Koji was mixed with 1000 g of purified water, extracted at 50 ° C. for 3 hours and then filtered to obtain 340 g of a germinated brown rice koji extract solution. . To this solution, 0.5 g of lipase was added, hydrolyzed at 50 ° C. for 3 hours, then heated at 80 ° C. for 1 hour to inactivate the enzyme, filtered, and light brown transparent germination 301 g of enzyme degradation product solution of brown rice bran extract was obtained (solid content concentration 2.11%).
製造例7.発芽玄米の糠のエキスの酵素分解物溶液の調製
発芽玄米の糠100gに精製水1000gを混合し、50℃で3時間抽出を行った後ろ過し、発芽玄米の糠のエキス溶液340gを得た。この溶液に対して、リパーゼ、パパイン、グルコアミラーゼ、セルラーゼを各々0.1gずつ添加し、50℃で3時間加水分解処理を行い、次いで80℃で1時間加熱して酵素を失活させた後ろ過し、淡褐色透明の発芽玄米の糠のエキスの酵素分解物溶液311gを得た(固形分濃度1.90%)。
Production Example 7 Preparation of Enzymatic Decomposition Solution of Germinated Brown Rice Koji Extract 100 g of Germinated Brown Rice Koji was mixed with 1000 g of purified water, extracted at 50 ° C. for 3 hours and then filtered to obtain 340 g of a germinated brown rice koji extract solution. . After adding 0.1 g each of lipase, papain, glucoamylase and cellulase to this solution, hydrolyzing at 50 ° C. for 3 hours, and then heating at 80 ° C. for 1 hour to deactivate the enzyme As a result, 311 g of an enzyme degradation product solution of a light brown transparent germinated brown rice bran extract was obtained (solid content concentration 1.90%).
製造例8.発芽玄米の糠のエキスの乳酸菌発酵物溶液の調製
発芽玄米の糠100gに精製水900gを混合し、80℃で2時間抽出を行った後ろ過し、約500gの淡黄色透明のエキス溶液を得た(固形分濃度3.87%)。この得られたエキス溶液を加熱殺菌した。この抽出物溶液にリパーゼ0.2g、パパイン0.2g、グルコアミラーゼ0.2g及びペクチナーゼ0.2gを加えた後、乳酸菌(ラクトバチルス プランタラム)を108個/mL接種し、窒素気流下に37℃で18時間静置培養した。培養終了後加熱殺菌し、培養液をろ過して、脱色処理を行い、発芽玄米の糠のエキスの乳酸菌発酵物溶液322g(固形分濃度3.67%)を得た。
Production Example 8 Preparation of fermented lactic acid bacteria solution of germinated brown rice bran extract Mix 100 g of germinated brown rice bran with 900 g of purified water, extract at 80 ° C. for 2 hours, and filter to obtain about 500 g of a pale yellow transparent extract solution. (Solid content concentration 3.87%). The obtained extract solution was sterilized by heating. After adding 0.2 g of lipase, 0.2 g of papain, 0.2 g of glucoamylase and 0.2 g of pectinase to this extract solution, inoculate 10 8 cells / mL of lactic acid bacteria (Lactobacillus plantarum) under nitrogen stream. The culture was allowed to stand at 37 ° C. for 18 hours. After culturing, the mixture was sterilized by heating, and the culture solution was filtered and decolorized to obtain 322 g (solid content concentration: 3.67%) of a fermented lactic acid bacterium solution of germinated brown rice bran extract.
製造例9.発芽玄米の糠のエキスの麹菌発酵物溶液の調製
発酵に用いる菌として乳酸菌に代えて麹菌(アスペルギルス オリゼー)を用いる他は製造例8と同様にして、発芽玄米の糠のエキスの麹菌発酵物溶液330g(固形分濃度3.69%)を得た。
Production Example 9 Preparation of a koji mold fermented solution of germinated brown rice koji extract A koji mold fermented solution of germinated brown rice koji extract as in Production Example 8 except that koji mold (Aspergillus oryzae) is used instead of lactic acid bacteria as the fungus used for fermentation 330 g (solid content concentration 3.69%) was obtained.
製造例10.発芽玄米の糠のエキスの酵母発酵物溶液の調製
発酵に用いる菌として乳酸菌に代えて酵母(サッカロミセス セレビシエ)を用いる他は製造例8と同様(但し、培養温度は30℃)にして、発芽玄米の糠のエキスの酵母発酵物溶液380g(固形分濃度3.22%)を得た。
Production Example 10 Preparation of fermented yeast solution of germinated brown rice koji extract Same as in Production Example 8 except that lactic acid bacteria are used instead of lactic acid bacteria as a bacterium used for fermentation (however, the culture temperature is 30 ° C.) 380 g (solid content concentration 3.22%) of yeast fermented product solution of koji extract was obtained.
製造例11.発芽玄米の糠のエキスの納豆菌発酵物溶液の調製
発酵に用いる菌として乳酸菌に代えて納豆菌(バシルス ナットー)を用いる他は製造例8と同様にして、発芽玄米の糠のエキスの納豆菌発酵物溶液312g(固形分濃度3.59%)を得た。
Production Example 11 Preparation of fermented natto fermented solution of germinated brown rice koji extract Natto fungus of germinated brown rice koji extract in the same manner as in Production Example 8, except that lactic acid bacteria were used as the fungus used for fermentation. 312 g of fermented product solution (solid content concentration 3.59%) was obtained.
製造例12.発芽玄米の糠のエキスのテンペ菌発酵物溶液の調製
発酵に用いる菌として麹菌に代えてテンペ菌(リゾプス ミクロスポラス オリゴスポラス)を用いる他は製造例8と同様にして、発芽玄米の糠のエキスのテンペ菌発酵物溶液392g(固形分濃度3.18%)を得た。
Production Example 12. Preparation of Tempe Bacteria Fermented Product Solution of Germinated Brown Rice Bran Extract Similar to Production Example 8, except for using Tempe Bacteria (Rhizopus microsporus oligospora) instead of Aspergillus as the fungus used for fermentation, 392 g (solid content concentration 3.18%) of a Tempe fungus fermentation product solution was obtained.
製造例13.発芽玄米の糠のエキスの乳酸菌発酵物溶液の調製
酵素の添加を行わず、又発酵日数を3日とする他は製造例8と同様にして、発芽玄米の糠のエキスの乳酸菌発酵物溶液332g(固形分濃度3.44%)を得た。
Production Example 13 Preparation of fermented lactic acid bacteria solution of germinated brown rice bran extract 332g of fermented lactic acid bacteria solution of germinated brown rice bran extract in the same manner as in Production Example 8 except that no enzyme was added and the fermentation period was 3 days. (Solid content concentration 3.44%) was obtained.
製造例14.発芽玄米の糠のエキスの麹菌発酵物溶液の調製
酵素の添加を行わず、又発酵日数を3日とする他は製造例9と同様にして、発芽玄米の糠のエキスの麹菌発酵物溶液339g(固形分濃度3.22%)を得た。
Production Example 14 Preparation of a koji mold fermented solution of germinated brown rice koji extract 339 g of a koji mold fermented solution of sprouted brown rice koji extract in the same manner as in Production Example 9 except that no enzyme was added and the fermentation period was 3 days. (Solid content concentration 3.22%) was obtained.
製造例15.発芽玄米の糠のエキスの酵母発酵物溶液の調製
酵素の添加を行わず、又発酵日数を3日とする他は製造例10と同様にして、発芽玄米の糠のエキスの酵母発酵物溶液360g(固形分濃度3.36%)を得た。
Production Example 15. Preparation of yeast fermented solution of germinated brown rice koji extract 360 g of yeast fermented solution of germinated brown rice koji extract in the same manner as in Production Example 10 except that no enzyme was added and the fermentation period was 3 days. (Solid content concentration 3.36%) was obtained.
製造例16.発芽玄米の糠のエキスの納豆菌発酵物溶液の調製
酵素の添加を行わず、又発酵日数を3日とする他は製造例11と同様にして、発芽玄米の糠のエキスの納豆菌発酵物溶液382g(固形分濃度3.45%)を得た。
Production Example 16. Preparation of fermented natto bacteria fermented solution of germinated brown rice bran extract In the same manner as in Production Example 11, except that no enzyme was added and the fermentation period was 3 days, fermented natto fungus of germinated brown rice bran extract 382 g of solution (solid content concentration 3.45%) was obtained.
製造例17.発芽玄米の糠のエキスのテンペ菌発酵物溶液の調製
酵素の添加を行わず、又発酵日数を3日とする他は製造例12と同様にして、発芽玄米の糠のエキスの発酵物溶液322g(固形分濃度3.39%)を得た。
Production Example 17 Preparation of fermented tempeh fungus solution of germinated brown rice pod extract 322 g of fermented solution of germinated brown rice bud extract in the same manner as in Production Example 12 except that no enzyme was added and the fermentation period was 3 days. (Solid content 3.39%) was obtained.
製造例18.発芽玄米の糠のエキスの乳酸菌発酵物溶液の調製
乳酸菌としてラクトバチルス プランタラムに代えてカルノバクテリウム ディバージェンスを用いる他は製造例8と同様にして、発芽玄米の糠のエキスの乳酸菌発酵物溶液304g(固形分濃度3.82%)を得た。
Production Example 18. Preparation of lactic acid bacteria fermented product solution of germinated brown rice pod extract Lactobacillus fermented product of germinated brown rice bud extract in the same manner as in Production Example 8 except that Lactobacillus plantarum is used as lactic acid bacteria instead of Lactobacillus plantarum 304 g of solution (solid content concentration 3.82%) was obtained.
製造例19.発芽玄米の糠のエキスの乳酸菌発酵物溶液の調製
乳酸菌としてラクトバチルス プランタラムに代えてロイコノストック メセンテロイズを用いる他は製造例8と同様にして、発芽玄米の糠のエキスの乳酸菌発酵溶液310g(固形分濃度3.61%)を得た。
Production Example 19. Preparation of lactic acid bacteria fermented product solution of germinated brown rice pod extract 310 g of lactic acid bacteria fermented solution of germinated brown rice bud extract in the same manner as in Production Example 8 except that Leuconostoc mesenteroids is used instead of Lactobacillus plantarum as lactic acid bacteria Solid content concentration 3.61%) was obtained.
製造例20.発芽玄米の糠の乳酸菌発酵物溶液の調製
発芽玄米の糠100gに精製水900gを混合して懸濁液を調製し、加熱殺菌した。この懸濁液にリパーゼ1.0g、パパイン1.0g、グルコアミラーゼ1.0g及びペクチナーゼ1.0gを加えた後、乳酸菌(ラクトバチルス プランタラム)を108個/mL接種し、窒素気流下に37℃で3日間静置培養した。培養終了後加熱殺菌し、培養液をろ過して、脱色処理を行い、発芽玄米の糠の乳酸菌発酵物溶液632g(固形分濃度4.12%)を得た。
Production Example 20. Preparation of fermented lactic acid bacteria solution of germinated brown rice pods A suspension was prepared by mixing 900 g of purified water with 100 g of germinated brown rice buds, and sterilized by heating. After adding 1.0 g of lipase, 1.0 g of papain, 1.0 g of glucoamylase and 1.0 g of pectinase to this suspension, inoculate 10 8 cells / mL of lactic acid bacteria (Lactobacillus plantarum) under nitrogen stream. The culture was stationary at 37 ° C. for 3 days. After completion of the culture, the mixture was sterilized by heating, the culture solution was filtered, and decolorization treatment was performed to obtain 632 g (solid content concentration: 4.12%) of a lactic acid bacteria fermentation product of germinated brown rice bran.
製造例21.発芽玄米の糠の酵母発酵物溶液の調製(2)
発芽玄米の糠100gに精製水900gを混合して懸濁液を調製し、加熱殺菌した。この懸濁液にリパーゼ1.0g、パパイン1.0g、グルコアミラーゼ1.0g及びペクチナーゼ1.0gを加えた後、酵母(サッカロミセス セレビシエ)を108個/mL接種し、30℃で3日間静置培養した。培養終了後加熱殺菌し、培養液をろ過して、脱色処理を行い、発芽玄米の糠の酵母発酵物溶液522g(固形分濃度3.99%)を得た。
Production Example 21. Preparation of yeast fermented solution of germinated brown rice bran (2)
A suspension was prepared by mixing 900 g of purified water with 100 g of germinated brown rice straw and sterilized by heating. To this suspension, 1.0 g of lipase, 1.0 g of papain, 1.0 g of glucoamylase and 1.0 g of pectinase were added, followed by inoculation of 10 8 cells / mL of yeast (Saccharomyces cerevisiae), and the mixture was allowed to stand at 30 ° C. for 3 days. Incubated. After culturing, the mixture was sterilized by heating, the culture solution was filtered, and decolorization treatment was performed to obtain 522 g (solid content concentration 3.99%) of a fermented brown rice bran yeast fermentation product.
製造例22.発芽玄米の糠のエキスの乳酸菌発酵物粉末の調製
製造例8と同様にして得た発芽玄米の糠のエキスの乳酸菌発酵物溶液300gを凍結乾燥し、これを粉砕して発芽玄米の糠のエキスの乳酸菌発酵物粉末12gを得た。
Production Example 22. Preparation of fermented lactic acid bacteria powder of germinated brown rice bran extract 300 g of lactic acid bacteria fermented solution of germinated brown rice bran extract obtained in the same manner as in Production Example 8 was freeze-dried and ground to extract germinated brown rice bran extract 12 g of lactic acid bacteria fermented powder was obtained.
製造例23.発芽玄米の糠のエキスの麹菌発酵物粉末の調製
製造例9と同様にして得た発芽玄米の糠のエキスの麹菌発酵物溶液300gを凍結乾燥し、これを粉砕して発芽玄米の糠のエキスの麹菌発酵物粉末11gを得た。
Production Example 23. Preparation of germinated brown rice koji extract powder of germinated brown rice koji extract 300 g of a germinated brown rice koji extract solution obtained in the same manner as in Production Example 9 was freeze-dried and pulverized to extract germinated brown rice koji extract 11 g of a koji mold powder was obtained.
製造例24.発芽玄米の糠のエキスの酵母発酵物粉末の調製
製造例10と同様にして得た発芽玄米の糠のエキスの酵母発酵物溶液300gを凍結乾燥し、これを粉砕して発芽玄米の糠のエキスの酵母発酵物粉末10gを得た。
Production Example 24. Preparation of fermented yeast rice powder of germinated brown rice pod extract 300 g yeast fermented yeast solution of germinated brown rice bud extract obtained in the same manner as in Production Example 10 was freeze-dried and pulverized to extract germinated brown rice potato extract 10 g of yeast fermented product powder was obtained.
製造例25.発芽玄米の糠のエキスの納豆菌発酵物粉末の調製
製造例11と同様にして得た発芽玄米の糠のエキスの納豆菌発酵物溶液300gを凍結乾燥し、これを粉砕して発芽玄米の糠のエキスの納豆菌発酵物粉末11gを得た。
Production Example 25. Preparation of fermented natto bacteria fermented powder of germinated brown rice koji extract 300 g of fermented natto fungus solution of germinated brown rice koji extract obtained in the same manner as in Production Example 11 was freeze-dried, pulverized, and germinated brown rice koji 11 g of fermented natto fermented powder was obtained.
製造例26.発芽玄米の糠のエキスのテンペ菌発酵物粉末の調製
製造例12と同様にして得た発芽玄米の糠のエキスのテンペ菌発酵物溶液300gを凍結乾燥し、これを粉砕して発芽玄米の糠のエキスのテンペ菌発酵物粉末11gを得た。
Production Example 26. Preparation of tempeh bacteria fermented powder of germinated brown rice koji extract 300 g of sprouting brown rice koji extract solution of sprouting brown rice koji extract obtained in the same manner as in Production Example 12 was freeze-dried and pulverized to give germinated brown rice koji 11 g of a tempe fungus fermentation powder was obtained.
比較製造例1.米糠エキスの調製
製造例1において、発芽玄米の糠に代えて、発芽していない普通米由来の米糠を使用する他は製造例1と同様にして、米糠エキス溶液を得た(固形分2.60%)。
Comparative Production Example 1 Preparation of rice bran extract In Production Example 1, a rice bran extract solution was obtained in the same manner as in Production Example 1 except that rice germ derived from non-germinated ordinary rice was used instead of germinated brown rice. 60%).
比較製造例2.米糠エキスの乳酸菌発酵物溶液の調製。
製造例8において、発芽玄米の糠に代えて、発芽していない普通米由来の米糠を使用する他は製造例8と同様にして、米糠エキスの乳酸菌発酵物溶液を得た。(固形分3.96%)。
Comparative Production Example 2 Preparation of fermented lactic acid bacteria solution of rice bran extract.
In Production Example 8, a lactic acid bacteria fermented solution of rice bran extract was obtained in the same manner as in Production Example 8, except that instead of germinated brown rice koji, rice germ derived from non-germinated ordinary rice was used. (Solid content 3.96%).
実施例1.クリーム
[A成分] 部
流動パラフィン 5.0
ヘキサラン (注1) 4.0
パラフィン 5.0
グリセリルモノステアレート 2.0
ポリオキシエチレン(20)ソルビタンモノステアレート 6.0
ブチルパラベン 0.1
(注1)株式会社テクノーブル製 トリオクタン酸グリセリル
[B成分]
製造例1の発芽玄米の糠のエキス溶液 10.0
グリセリン 5.0
メチルパラベン 0.1
モイストン・C (注2) 1.0
精製水 全量が100部となる量
(注2)株式会社テクノーブル製 NMF成分
[C成分]
香料 適量
上記のA成分とB成分をそれぞれ80℃以上に加熱した後、攪拌混合した。これを50℃まで冷却した後、C成分を加えてさらに攪拌混合してクリームを得た。
Example 1. Cream [Component A] Liquid paraffin 5.0
Hexalan (Note 1) 4.0
Paraffin 5.0
Glyceryl monostearate 2.0
Polyoxyethylene (20) sorbitan monostearate 6.0
Butylparaben 0.1
(Note 1) Technoble Co., Ltd. glyceryl trioctanoate
[B component]
Germination brown rice bran extract solution of Production Example 1 10.0
Glycerin 5.0
Methylparaben 0.1
Moiston C (Note 2) 1.0
Amount of purified water totaling 100 parts
(Note 2) NMF component manufactured by Technoble Co., Ltd.
[C component]
Perfume
The components A and B were each heated to 80 ° C. or higher and then mixed by stirring. After this was cooled to 50 ° C., component C was added and further stirred and mixed to obtain a cream.
実施例2.クリーム
実施例1のB成分中、製造例1の発芽玄米の糠のエキス溶液に代えて製造例3の発芽玄米の糠のエキス溶液を用いるほかは実施例1と同様にしてクリームを得た。
Example 2 Cream A cream was obtained in the same manner as in Example 1 except that the germinated brown rice bran extract solution of Production Example 1 was used instead of the germinated brown rice bran extract solution of Production Example 1 in the component B of Example 1.
実施例3.クリーム
実施例1のB成分中、製造例1の発芽玄米の糠のエキス溶液に代えて製造例4の発芽玄米の糠のエキス溶液を用いるほかは実施例1と同様にしてクリームを得た。
Example 3 Cream A cream was obtained in the same manner as in Example 1 except that the germinated brown rice bran extract solution of Production Example 1 was used instead of the germinated brown rice bran extract solution of Production Example 1 in the component B of Example 1.
実施例4.クリーム
実施例1のB成分中、製造例1の発芽玄米の糠のエキス溶液に代えて製造例8の発芽玄米の糠のエキスの乳酸菌発酵物溶液を用いるほかは実施例1と同様にしてクリームを得た。
Example 4 Cream In the same manner as in Example 1, except that the lactic acid bacteria fermented solution of the germinated brown rice bran extract of Production Example 8 is used instead of the germinated brown rice bran extract solution of Production Example 1 in the component B of Example 1 Got.
実施例5.クリーム
実施例1のB成分中、製造例1の発芽玄米の糠のエキス溶液に代えて製造例11の発芽玄米の糠のエキスの納豆菌発酵物溶液を用いるほかは実施例1と同様にしてクリームを得た。
Example 5 FIG. Cream In the same manner as in Example 1, except that the B component of Example 1 was replaced with the germinated brown rice bran extract solution of Production Example 1 and the fermented natto fermentation solution of germinated brown rice bran extract of Production Example 11 was used. A cream was obtained.
実施例6.クリーム
実施例1のB成分中、製造例1の発芽玄米の糠のエキス溶液に代えて製造例10の発芽玄米の糠のエキスの酵母発酵物溶液を用いるほかは実施例1と同様にしてクリームを得た。
Example 6 Cream In the same manner as in Example 1, except that the fermented brown rice bran extract solution of Production Example 10 was used instead of the germinated brown rice bran extract solution of Production Example 1 in the component B of Example 1. Got.
実施例7.クリーム
実施例1のB成分中、製造例1の発芽玄米の糠のエキス溶液に代えて製造例12の発芽玄米の糠のエキスのテンペ菌発酵物溶液を用いるほかは実施例1と同様にしてクリームを得た。
Example 7 Cream In the same manner as in Example 1, except that the tempered fungus solution of the germinated brown rice bran extract of Production Example 12 was used in the component B of Example 1 instead of the germinated brown rice bran extract solution of Production Example 1. A cream was obtained.
実施例8.クリーム
実施例1のB成分中、製造例1の発芽玄米の糠のエキス溶液液に代えて製造例18の発芽玄米の糠のエキスの乳酸菌発酵物溶液を用いるほかは実施例1と同様にしてクリームを得た。
Example 8 FIG. Cream In the same manner as in Example 1, except that in the component B of Example 1, the germinated brown rice bran extract solution of Production Example 1 was used instead of the germinated brown rice bran extract of Production Example 18 A cream was obtained.
実施例9.クリーム
実施例1のB成分中、製造例1の発芽玄米の糠のエキス溶液に代えて製造例6の発芽玄米の糠のエキスの酵素分解物溶液を用いるほかは実施例1と同様にしてクリームを得た。
Example 9 Cream In the same manner as in Example 1, except that the enzyme decomposed product solution of the germinated brown rice bran extract of Production Example 6 was used in the component B of Example 1 instead of the germinated brown rice bran extract solution of Production Example 1 Got.
実施例10.クリーム
実施例1のB成分中、製造例1の発芽玄米の糠のエキス溶液に代えて製造例7の発芽玄米の糠のエキスの酵素分解物溶液を用いるほかは実施例1と同様にしてクリームを得た。
Example 10 Cream In the same manner as in Example 1 except that the enzyme decomposed product solution of germinated brown rice bran extract of Production Example 7 was used in the component B of Example 1 instead of the germinated brown rice bran extract solution of Production Example 1 Got.
実施例11.クリーム
実施例1のB成分中、製造例1の発芽玄米の糠のエキス溶液に代えて製造例20の発芽玄米の糠の乳酸菌発酵物溶液を用いるほかは実施例1と同様にしてクリームを得た。
Example 11 Cream In the component B of Example 1, a cream was obtained in the same manner as in Example 1 except that the germinated brown rice bran lactic acid bacteria fermented solution of Production Example 20 was used instead of the germinated brown rice bran extract solution of Production Example 1. It was.
実施例12.乳液
[A成分] 部
流動パラフィン 6.0
ヘキサラン 4.0
ホホバ油 1.0
ポリオキシエチレン(20)ソルビタンモノステアレート 2.0
大豆レシチン 1.5
メチルパラベン 0.15
エチルパラベン 0.03
[B成分]
製造例1の発芽玄米の糠のエキス溶液 10.0
グリセリン 3.0
1、3−ブチレングリコール 2.0
カルボキシメチルセルロース 0.3
ヒアルロン酸ナトリウム 0.01
精製水 全量が100部となる量
[C成分]
香料 適量
上記のA成分とB成分をそれぞれ80℃以上に加熱した後、攪拌混合した。これを50℃まで冷却した後、C成分を加えてさらに攪拌混合して乳液を得た。
Example 12 Emulsion [component A] part liquid paraffin 6.0
Hexalan 4.0
Jojoba oil 1.0
Polyoxyethylene (20) sorbitan monostearate 2.0
Soy lecithin 1.5
Methylparaben 0.15
Ethylparaben 0.03
[B component]
Germination brown rice bran extract solution of Production Example 1 10.0
Glycerin 3.0
1,3-butylene glycol 2.0
Carboxymethylcellulose 0.3
Sodium hyaluronate 0.01
Amount of purified water totaling 100 parts
[C component]
Perfume
The components A and B were each heated to 80 ° C. or higher and then mixed by stirring. After cooling this to 50 ° C., component C was added and further stirred and mixed to obtain an emulsion.
実施例13.ローション
[成分] 部
製造例9の発芽玄米の糠のエキスの麹菌発酵物溶液 10.0
エタノール 10.0
グリセリン 3.0
1、3−ブチレングリコール 2.0
メチルパラベン 0.2
クエン酸 0.1
クエン酸ナトリウム 0.3
カルボキシビニルポリマー 0.1
香料 適量
水酸化カリウム 適量
精製水 全量が100部となる量
上記の成分を混合してローションを得た。
Example 13 Lotion [Ingredients] part Bacteria fermented fermented solution of germinated brown rice bran extract of Production Example 10.0 10.0
Ethanol 10.0
Glycerin 3.0
1,3-butylene glycol 2.0
Methylparaben 0.2
Citric acid 0.1
Sodium citrate 0.3
Carboxyvinyl polymer 0.1
Perfume
Potassium hydroxide appropriate amount Purified water Amount that makes 100 parts in total
The above ingredients were mixed to obtain a lotion.
実施例14.化粧水
[A成分] 部
オリーブ油 1.0
ポリオキシエチレン(5.5)セチルエーテル 0.5
ブチルパラベン 0.1
[B成分]
製造例12の発芽玄米の糠のエキスのテンペ菌発酵物溶液 10.0
エタノール 5.0
グリセリン 5.0
1,3−ブチレングリコール 5.0
メチルパラベン 0.1
水酸化カリウム 適量
精製水 全量が100部となる量
[C成分]
香料 適量
A成分及びB成分をそれぞれ80℃以上に加温後、A成分にB成分を加えて攪拌し、さらにヒスコトロン(5000rpm)で2分間ホモジナイズを行った。
これを50℃まで冷却した後、C成分を加えて攪拌混合し、さらに30℃以下まで冷却して化粧水を得た。
Example 14 Lotion [component A] part olive oil 1.0
Polyoxyethylene (5.5) cetyl ether 0.5
Butylparaben 0.1
[B component]
Tempered Bacteria Fermentation Solution of Germinated Brown Rice Bran Extract of Production Example 12 10.0
Ethanol 5.0
Glycerin 5.0
1,3-butylene glycol 5.0
Methylparaben 0.1
Potassium hydroxide appropriate amount Purified water Amount that makes 100 parts in total
[C component]
Perfume
After each component A and component B was heated to 80 ° C. or higher, the component B was added to the component A and stirred, and further homogenized with Hiscotron (5000 rpm) for 2 minutes.
After cooling this to 50 degreeC, C component was added and stirred and mixed, and also it cooled to 30 degrees C or less, and the lotion was obtained.
実施例15.乳液
実施例12のB成分中、製造例1の発芽玄米の糠のエキス溶液に代えて製造例21の発芽玄米の糠の酵母発酵物溶液を用いるほかは実施例12と同様にして乳液を得た。
Example 15. Emulsion Emulsion is obtained in the same manner as in Example 12 except that the fermented brown rice bran extract solution of Production Example 21 is used in the component B of Example 12 instead of the germinated brown rice bran extract solution of Production Example 1. It was.
実施例16.乳液
実施例12のB成分中、製造例1の発芽玄米の糠のエキス溶液に代えて製造例13の発芽玄米の糠のエキスの乳酸菌発酵物溶液を用いるほかは実施例12と同様にして乳液を得た。
Example 16 Emulsion In the same manner as in Example 12, except that the germinated brown rice bran extract solution of Production Example 13 was used in the component B of Example 12 instead of the germinated brown rice bran extract solution of Production Example 13. Got.
実施例17.乳液
実施例12のB成分中、製造例1の発芽玄米の糠のエキス溶液に代えて製造例14の発芽玄米の糠のエキスの麹菌発酵物溶液を用いるほかは実施例12と同様にして乳液を得た。
Example 17. Emulsion In the same manner as in Example 12, except that the germinated brown rice koji extract solution of Production Example 14 was used instead of the germinated brown rice koji extract solution of Production Example 1 in the component B of Example 12. Got.
実施例18.乳液
実施例12のB成分中、製造例1の発芽玄米の糠のエキス溶液に代えて製造例15の発芽玄米の糠のエキスの酵母発酵物溶液を用いるほかは実施例12と同様にして乳液を得た。
Example 18 Emulsion Emulsion in the same manner as in Example 12 except that the fermented brown rice bran extract solution of Production Example 15 was used instead of the fermented brown rice bran extract solution of Production Example 1 in the component B of Example 12. Got.
実施例19.乳液
実施例12のB成分中、製造例1の発芽玄米の糠のエキス溶液に代えて製造例16の発芽玄米の糠の納豆菌発酵物溶液を用いるほかは実施例12と同様にして乳液を得た。
Example 19. Emulsion In the component B of Example 12, the milk solution was prepared in the same manner as in Example 12, except that the germinated brown rice bran natto fermentation solution of Production Example 16 was used instead of the germinated brown rice bran extract solution of Production Example 1. Obtained.
実施例20.乳液
[A成分] 部
流動パラフィン 6.0
ヘキサラン 4.0
ホホバ油 1.0
ポリオキシエチレン(20)ソルビタンモノステアレー 2.0
大豆レシチン 1.5
メチルパラベン 0.15
エチルパラベン 0.03
[B成分]
製造例1の発芽玄米の糠のエキス溶液 10.0
L−アスコルビン酸−2−グルコシド 2.0
グリセリン 3.0
1、3−ブチレングリコール 2.0
カルボキシメチルセルロース 0.3
ヒアルロン酸ナトリウム 0.01
水酸化カリウム 適量
精製水 全量が100部となる量
[C成分]
香料 適量
上記のA成分とB成分をそれぞれ80℃以上に加熱した後、攪拌混合した。これを50℃まで冷却した後、C成分を加えてさらに攪拌混合して乳液を得た。
Example 20. Emulsion [component A] part liquid paraffin 6.0
Hexalan 4.0
Jojoba oil 1.0
Polyoxyethylene (20) sorbitan monosteare 2.0
Soy lecithin 1.5
Methylparaben 0.15
Ethylparaben 0.03
[B component]
Germination brown rice bran extract solution of Production Example 1 10.0
L-ascorbic acid-2-glucoside 2.0
Glycerin 3.0
1,3-butylene glycol 2.0
Carboxymethylcellulose 0.3
Sodium hyaluronate 0.01
Potassium hydroxide Appropriate amount Purified water Amount that makes the total amount 100 parts [Component C]
Fragrance Appropriate amount Each of the above components A and B was heated to 80 ° C. or higher, and then mixed by stirring. After cooling this to 50 ° C., component C was added and further stirred and mixed to obtain an emulsion.
実施例21.乳液
実施例20のB成分中、L−アスコルビン酸−2−グルコシド2.0部及び水酸化カリウム0.5部に代えてL−アスコルビン酸−2−リン酸エステルマグネシウム2.0部を用いるほかは実施例20と同様にして乳液を得た。
Example 21. Emulsion In addition to using 2.0 parts of L-ascorbic acid-2-phosphoside magnesium in place of 2.0 parts of L-ascorbic acid-2-glucoside and 0.5 parts of potassium hydroxide in the component B of Example 20 Obtained an emulsion in the same manner as in Example 20.
実施例22.乳液
実施例20のB成分中、L−アスコルビン酸−2−グルコシド2.0部及び水酸化カリウム0.5部に代えてL−アスコルビン酸−2−リン酸エステルナトリウム2.0部を用いるほかは実施例20と同様にして乳液を得た。
Example 22. Emulsion In addition to using 2.0 parts of L-ascorbic acid-2-phosphate sodium salt in place of 2.0 parts of L-ascorbic acid-2-glucoside and 0.5 part of potassium hydroxide in the component B of Example 20 Obtained an emulsion in the same manner as in Example 20.
実施例23.乳液
実施例20のB成分中、L−アスコルビン酸−2−グルコシド2.0部及び水酸化カリウム0.5部に代えてアルブチン2.0部を用いるほかは実施例20と同様にして乳液を得た。
Example 23. Emulsion In the component B of Example 20, the emulsion was prepared in the same manner as in Example 20 except that 2.0 parts of arbutin was used instead of 2.0 parts of L-ascorbic acid-2-glucoside and 0.5 parts of potassium hydroxide. Obtained.
実施例24.乳液
実施例20のB成分中、L−アスコルビン酸−2−グルコシド2.0部及び水酸化カリウム0.5部に代えて米糠抽出物加水分解物(株式会社テクノーブル製、商品名「グレイスノウ*雪*AE」、固形分濃度3.5%)5.0部を用いるほかは実施例20と同様にして乳液を得た。
Example 24. Latex In the component B of Example 20, in place of 2.0 parts of L-ascorbic acid-2-glucoside and 0.5 part of potassium hydroxide, a rice bran extract hydrolyzate (trade name “Grace Snow” manufactured by Technoble Co., Ltd.) An emulsion was obtained in the same manner as in Example 20 except that 5.0 parts of * Snow * AE ", solid concentration 3.5%) were used.
実施例25.乳液
実施例20のB成分中、L−アスコルビン酸−2−グルコシド2.0部及び水酸化カリウム0.5部に代えて白芥子(Brassica Alba)種子抽出物(株式会社テクノーブル製、商品名「シナブランカ−WH」、固形分濃度1.0%)5.0部を用いるほかは実施例20と同様にして乳液を得た。
Example 25. Latex In the component B of Example 20, instead of 2.0 parts of L-ascorbic acid-2-glucoside and 0.5 part of potassium hydroxide, white seed (Brassica Alba) seed extract (trade name, manufactured by Technoble Co., Ltd.) An emulsion was obtained in the same manner as in Example 20 except that 5.0 parts of “Sinablanca-WH” (solid content concentration 1.0%) were used.
実施例26.乳液
実施例20のB成分中、L−アスコルビン酸−2−グルコシド2.0部及び水酸化カリウム0.5部に代えてγ−アミノ−β−ヒドロキシ酪酸1.0部を用いるほかは実施例20と同様にして乳液を得た。
Example 26. Emulsion Example 20 except for using 2.0 parts of L-ascorbic acid-2-glucoside and 0.5 part of potassium hydroxide in the component B of Example 20 except that 1.0 part of γ-amino-β-hydroxybutyric acid is used. In the same manner as in No. 20, an emulsion was obtained.
実施例27.乳液
実施例20のB成分中、L−アスコルビン酸−2−グルコシド2.0部及び水酸化カリウム0.5部に代えて米抽出物加水分解物(株式会社テクノーブル製、商品名「オリゼノーブル」、固形分濃度1.5%)5.0部を用いるほかは実施例20と同様にして乳液を得た。
Example 27. Latex In the component B of Example 20, instead of 2.0 parts of L-ascorbic acid-2-glucoside and 0.5 parts of potassium hydroxide, a rice extract hydrolyzate (trade name “Orisenoble, manufactured by Technoble Co., Ltd.) A solid emulsion of 1.5% was obtained in the same manner as in Example 20 except that 5.0 parts were used.
実施例28.ローション
[成分] 部
製造例1の発芽玄米の糠のエキス溶液 10.0
L−アスコルビン酸−2−グルコシド 2.0
エタノール 10.0
グリセリン 3.0
1、3−ブチレングリコール 2.0
メチルパラベン 0.2
クエン酸 0.1
クエン酸ナトリウム 0.3
アルギン酸ナトリウム 0.1
水酸化カリウム 適量
香料 適量
精製水 全量が100部となる量
上記の成分を混合してローションを得た。
Example 28. Lotion [Ingredient] part Germinated brown rice bran extract solution of Production Example 1 10.0
L-ascorbic acid-2-glucoside 2.0
Ethanol 10.0
Glycerin 3.0
1,3-butylene glycol 2.0
Methylparaben 0.2
Citric acid 0.1
Sodium citrate 0.3
Sodium alginate 0.1
Potassium hydroxide Appropriate amount Perfume Appropriate amount Purified water An amount that makes the total amount 100 parts The above ingredients were mixed to obtain a lotion.
実施例29.プレストパウダー
[A成分 部
ベンガラ 0.5
黄酸化鉄 1.5
黒酸化鉄 0.1
酸化チタン 10.0
6−ナイロンパウダー 4.0
セリサイト 全量が100部となる量
マイカ 23.0
タルク 25.0
製造例5の発芽玄米の糠のエキス粉末 0.2
[B成分]
スクワラン 1.0
メチルポリシロキサン 4.0
プロピルパラベン 0.1
デヒドロ酢酸 0.1
流動パラフィン 2.0
香料 適量
上記のA成分とB成分をそれぞれ混合攪拌し混合した後、200メッシュのタイラーメッシュの篩にかけ、得られた混合粉末を金型に打型してプレストパウダーを得た。
Example 29. Pressed powder [A component part Bengala 0.5
Yellow iron oxide 1.5
Black iron oxide 0.1
Titanium oxide 10.0
6-Nylon powder 4.0
Amount that makes 100 parts of sericite Mica 23.0
Talc 25.0
Germinated brown rice bran extract powder of Production Example 5 0.2
[B component]
Squalane 1.0
Methylpolysiloxane 4.0
Propylparaben 0.1
Dehydroacetic acid 0.1
Liquid paraffin 2.0
Perfume
The above A component and B component were mixed and agitated, mixed, then passed through a 200 mesh Tyler mesh sieve, and the resulting mixed powder was cast into a mold to obtain a pressed powder.
実施例30.リキッドファンデーション
[A成分] 部
ステアリン酸 2.4
モノステアリン酸プロピレングリコール 2.0
セトステアリルアルコール 0.2
液状ラノリン 2.0
流動パラフィン 3.0
ミリスチン酸イソプロピル 8.5
プロピルパラベン 0.05
[B成分]
製造例12の発芽玄米の糠のエキスのテンペ菌発酵物溶液 5.0
カルボキシメチルセルロースナトリウム 0.2
ベントナイト 0.5
プロピレングリコール 4.0
トリエタノールアミン 1.1
メチルパラベン 0.1
精製水 全量が100部となる量
[C成分]
酸化チタン 8.0
タルク 4.0
着色顔料 適量
上記のA成分とB成分をそれぞれ加温した後混合攪拌した。これを再加温し、上記のC成分を添加して型に流し込み、室温になるまで攪拌してリキッドファンデーションを得た。
Example 30. FIG. Liquid foundation [component A] part Stearic acid 2.4
Propylene glycol monostearate 2.0
Cetostearyl alcohol 0.2
Liquid lanolin 2.0
Liquid paraffin 3.0
Isopropyl myristate 8.5
Propylparaben 0.05
[B component]
Tempe Fungus Fermented Solution of Germinated Brown Rice Bran Extract of Production Example 12 5.0
Sodium carboxymethylcellulose 0.2
Bentonite 0.5
Propylene glycol 4.0
Triethanolamine 1.1
Methylparaben 0.1
Purified water Amount that makes the total amount 100 parts [C component]
Titanium oxide 8.0
Talc 4.0
Coloring pigment appropriate amount The components A and B were heated and mixed and stirred. This was reheated, the above C component was added, poured into a mold, and stirred until it reached room temperature to obtain a liquid foundation.
実施例31.クリームファンデーション
[A成分] 部
ステアリン酸 5.0
セタノール 2.0
モノステアリン酸グリセリル 3.0
流動パラフィン 5.0
スクワラン 3.0
ミリスチン酸イソプロピル 8.0
ポリオキシエチレン(20)モノステアリン酸グリセリル 2.0
プロピルパラベン 0.1
[B成分]
製造例1の発芽玄米の糠のエキス溶液 5.0
ソルビトール 3.0
1,3−ブチレングリコール 5.0
トリエタノールアミン 1.5
メチルパラベン 0.1
精製水 全量が100部となる量
[C成分]
酸化チタン 8.0
タルク 2.0
カオリン 5.0
ベントナイト 1.0
着色顔料 適 量
[D成分]
香料 0.3
C成分を混合し、粉砕機で粉砕した。B成分を混合し、これに粉砕したC成分を加え、コロイドミルで均一分散させた。A成分及び均一分散させたB、C成分をそれぞれ80℃に加温後、B、C成分にA成分を攪拌しながら加え、さらにヒスコトロン(5000rpm)で2分間ホモジナイズを行った。これを50℃まで冷却した後、D成分を加えて攪拌混合し、さらに攪拌しながら30℃以下まで冷却してクリームファンデーションを得た。
Example 31. Cream foundation [component A] part Stearic acid 5.0
Cetanol 2.0
Glyceryl monostearate 3.0
Liquid paraffin 5.0
Squalane 3.0
Isopropyl myristate 8.0
Polyoxyethylene (20) glyceryl monostearate 2.0
Propylparaben 0.1
[B component]
Germinated brown rice bran extract solution of Production Example 1 5.0
Sorbitol 3.0
1,3-butylene glycol 5.0
Triethanolamine 1.5
Methylparaben 0.1
Purified water Amount of 100 parts [component C]
Titanium oxide 8.0
Talc 2.0
Kaolin 5.0
Bentonite 1.0
Coloring pigment appropriate amount [component D]
Fragrance 0.3
Component C was mixed and pulverized with a pulverizer. The component B was mixed, and the pulverized component C was added thereto and uniformly dispersed in a colloid mill. The components A and B and C dispersed uniformly were each heated to 80 ° C., and then the components A were added to the components B and C while stirring, and further homogenized with Hiscotron (5000 rpm) for 2 minutes. After cooling this to 50 degreeC, D component was added and stirred and mixed, and also it cooled to 30 degrees C or less, stirring, and obtained the cream foundation.
実施例32.ヘアートニック
[A成分] 部
エタノール 60.0
O−メチルセファラノリン 0.002
l−メントール 0.5
香料 0.1
メチルパラベン 0.1
[B成分]
グリセリン 2.0
1,3−ブチレングリコール 2.0
製造例17の発芽玄米の糠のエキスのテンペ菌発酵物溶液 10.0
精製水 全量が100部となる量
上記のA成分とB成分をそれぞれ常温で溶解した後、A成分にB成分を攪拌しながら加え溶解させてヘアートニックを得た。
Example 32. Hair artic [component A] part ethanol 60.0
O-methylcephalanoline 0.002
l-Menthol 0.5
Fragrance 0.1
Methylparaben 0.1
[B component]
Glycerin 2.0
1,3-butylene glycol 2.0
Tempered Bacteria Fermented Solution of Germinated Brown Rice Bran Extract of Production Example 17 10.0
Purified water in an amount of 100 parts The above A component and B component were each dissolved at room temperature, then the B component was added to the A component with stirring and dissolved to obtain a hair-tonic.
実施例33.ヘアートリートメント
[成分] 部
塩化ステアリルトリメチルアンモニウム 6.0
ポリビニルピロリドン 4.0
グリセリン 1.0
エチルパラベン 0.1
製造例8の発芽玄米の糠のエキスの乳酸菌発酵物溶液 5.0
精製水 全量が100部となる量
上記の成分を80℃に加温した後混合攪拌してヘアートリートメントを得た。本品はヘアーパックとしても好適なものであった。
Example 33. Hair treatment [ingredient] part stearyltrimethylammonium chloride 6.0
Polyvinylpyrrolidone 4.0
Glycerin 1.0
Ethylparaben 0.1
Lactic acid bacteria fermented solution of germinated brown rice bran extract of Production Example 8 5.0
Purified water in a total amount of 100 parts The above ingredients were heated to 80 ° C and then mixed and stirred to obtain a hair treatment. This product was also suitable as a hair pack.
実施例34.ヘアーシャンプー
[A成分] 部
N−ヤシ油脂肪酸メチルタウリンナトリウム 10.0
ポリオキシエチレン(3)アルキルエーテル硫酸ナトリウム 20.0
ラウリルジメチルアミノ酢酸ベタイン 10.0
ヤシ油脂肪酸ジエタノールアミド 4.0
メチルパラベン 0.1
[B成分]
クエン酸 0.1
製造例1の発芽玄米の糠のエキス溶液 5.0
1,3−ブチレングリコール 2.0
精製水 全量が100部となる量
A成分及びB成分をそれぞれ80℃に加温して均一に溶解した後、A成分にB成分を加え、攪拌を続けて室温まで冷却してヘアーシャンプーを得た。
Example 34. Hair shampoo [component A] part N-coconut oil fatty acid methyl taurine sodium 10.0
Polyoxyethylene (3) sodium alkyl ether sulfate 20.0
Lauryldimethylaminoacetic acid betaine 10.0
Palm oil fatty acid diethanolamide 4.0
Methylparaben 0.1
[B component]
Citric acid 0.1
Germinated brown rice bran extract solution of Production Example 1 5.0
1,3-butylene glycol 2.0
Purified water Amounts of 100 parts in total A and B components were each heated to 80 ° C and dissolved uniformly, then B component was added to A component and stirring continued to cool to room temperature to obtain a hair shampoo It was.
実施例35.ヘアーリンス
[A成分] 部
ポリオキシエチレン(10)硬化ヒマシ油 1.0
塩化ジステアリルジメチルアンモニウム 1.5
塩化ステアリルトリメチルアンモニウム 2.0
2−エチルヘキサン酸グリセリル 1.0
セタノール 3.2
ステアリルアルコール 1.0
メチルパラベン 0.1
[B成分]
製造例19の発芽玄米の糠のエキスの乳酸菌発酵物溶液 5.0
1,3−ブチレングリコール 5.0
精製水 全量が100部となる量
A成分及びB成分をそれぞれ80℃に加温して均一に溶解した後、A成分にB成分を加え、攪拌を続けて室温まで冷却してヘアーリンスを得た。
Example 35. Hair rinse [component A] Part Polyoxyethylene (10) hydrogenated castor oil 1.0
Distearyldimethylammonium chloride 1.5
Stearyltrimethylammonium chloride 2.0
Glyceryl 2-ethylhexanoate 1.0
Cetanol 3.2
Stearyl alcohol 1.0
Methylparaben 0.1
[B component]
Lactic acid bacteria fermented product solution of germinated brown rice bran extract of Production Example 19 5.0
1,3-butylene glycol 5.0
Purified water Amount to be 100 parts A component and B component are each heated to 80 ° C and dissolved uniformly, then B component is added to A component and stirring is continued to cool to room temperature to obtain hair rinse It was.
実施例36.ボディシャンプー
[A成分] 部
N−ラウロイルメチルアラニンナトリウム 25.0
ヤシ油脂肪酸カリウム液(40%) 26.0
ヤシ油脂肪酸ジエタノールアミド 3.0
メチルパラベン 0.1
[B成分]
製造例1の発芽玄米の糠のエキス溶液 10.0
1,3−ブチレングリコール 2.0
精製水 全量が100部となる量
A成分及びB成分をそれぞれ80℃に加温して均一に溶解した後、A成分にB成分を加え、攪拌を続けて室温まで冷却してボディシャンプーを得た。
Example 36. Body shampoo [component A] part N-lauroylmethylalanine sodium 25.0
Palm oil fatty acid potassium liquid (40%) 26.0
Palm oil fatty acid diethanolamide 3.0
Methylparaben 0.1
[B component]
Germination brown rice bran extract solution of Production Example 1 10.0
1,3-butylene glycol 2.0
Purified water Amount to be 100 parts A component and B component are each heated to 80 ° C and dissolved uniformly, then B component is added to A component and stirring is continued to cool to room temperature to obtain a body shampoo It was.
実施例37.石けん
[A成分] 部
硬化ヒマシ油 26.0
ヤシ油 10.0
オリーブ油 4.0
[B成分]
水酸化ナトリウム 6.0
砂糖 10.0
グリセリン 5.0
製造例22の発芽玄米の糠のエキスの乳酸菌発酵物粉末 0.5
精製水 全量が100部となる量
[C成分]
エタノール 20.0
香料 適量
A成分及びB成分をそれぞれ80℃に加温して均一に溶解した後、A成分にB成分を加えてケン化した。これを攪拌しながら50℃まで冷却し、C成分を加えた。これを型に流し込み冷却した後、室温下で数日間乾燥させ、充分に乾燥したものを型から取りだして石けんを得た。
Example 37. Soap [component A] part hardened castor oil 26.0
Coconut oil 10.0
Olive oil 4.0
[B component]
Sodium hydroxide 6.0
Sugar 10.0
Glycerin 5.0
Fermented lactic acid bacteria powder of germinated brown rice bran extract of Production Example 22 0.5
Purified water Amount of 100 parts [component C]
Ethanol 20.0
Fragrance Appropriate amounts of A component and B component were each heated to 80 ° C. and dissolved uniformly, and then B component was added to A component to saponify. This was cooled to 50 ° C. with stirring, and component C was added. This was poured into a mold and cooled, and then dried at room temperature for several days. A sufficiently dried product was taken out from the mold to obtain soap.
比較実施例1.クリーム
実施例1のB成分中、製造例1の発芽玄米の糠のエキス溶液に代えて比較製造例1の普通米由来の糠のエキス溶液を用いるほかは実施例1と同様にしてクリームを得た。
Comparative Example 1 Cream In the component B of Example 1, a cream was obtained in the same manner as in Example 1 except that instead of the germinated brown rice koji extract solution of Production Example 1, the koji extract solution derived from plain rice of Comparative Production Example 1 was used. It was.
比較実施例2.クリーム
実施例1のB成分中、製造例1の発芽玄米の糠のエキス溶液に代えて比較製造例2の普通米由来の糠エキスの乳酸菌発酵物溶液を用いるほかは実施例1と同様にしてクリームを得た。
Comparative Example 2 Cream In the same manner as in Example 1 except that, in the component B of Example 1, the sprouting brown rice koji extract solution of Production Example 1 was used instead of the common rice-derived koji extract of Comparative Production Example 2. A cream was obtained.
試験例1.線維芽細胞賦活試験
製造例1〜3、6及び8〜12で得られた発芽玄米の糠のエキス、その酵素処理物溶液及びその発酵物溶液(以上、本発明例)と比較製造例1及び2で得られた普通米の糠のエキスおよびその発酵物溶液(以上、比較例)を試料として用い、それらを各々精製水で希釈して固形分が1%となるように調整した溶液について線維芽細胞の活性に対する亢進作用を調べた。
Test Example 1 Fibroblast activation test Germinated brown rice bran extract obtained in Production Examples 1 to 3, 6 and 8 to 12, its enzyme-treated product solution and its fermented product solution (invention example) and Comparative Production Example 1 and The solution of the ordinary rice bran extract obtained in 2 and its fermented product solution (hereinafter referred to as Comparative Example) as a sample and diluted with purified water to adjust the solid content to 1%. The enhancing effect on blast activity was examined.
[試験方法]
ヒト皮膚真皮由来線維芽細胞NB1RGBを、0.5%NCS含有最小必須培地を入れた96穴マイクロプレートに1×104個/穴播種し、37℃で1日間プレ培養した後、培地に試料溶液を2.5又は5.0%の濃度(溶液濃度として)になるように添加して、37℃でさらに3日間培養した。次に培地を除去し界面活性剤(TRITON X−100)を添加した細胞処理液に、0.2%のMTTを添加して37℃に保持した後、波長370〜630nmでMTTが還元されて生成するホルマザンを測定した。また、試験系が正常に機能しているかを確認するために、試験試料の代わりにグルコースを100mM添加した場合及び試料無添加の場合(コントロール)について同様の試験を行った。
各試料の線維芽細胞賦活効果は、波長370〜630nmに於ける吸光度(MTT活性)を以て示した。
[Test method]
Human skin dermis-derived fibroblasts NB1RGB are seeded at 1 × 10 4 cells / well in a 96-well microplate containing 0.5% NCS-containing minimum essential medium, pre-cultured at 37 ° C. for 1 day, and then sampled in the medium The solution was added to a concentration of 2.5 or 5.0% (as a solution concentration) and cultured at 37 ° C. for another 3 days. Next, 0.2% of MTT was added to the cell treatment solution to which the medium was removed and the surfactant (TRITON X-100) was added and maintained at 37 ° C., and then MTT was reduced at a wavelength of 370 to 630 nm. The formazan produced was measured. Moreover, in order to confirm whether the test system is functioning normally, the same test was performed when 100 mM of glucose was added instead of the test sample and when no sample was added (control).
The fibroblast activation effect of each sample was shown by absorbance (MTT activity) at a wavelength of 370 to 630 nm.
[結果]
結果を表1に示す。表1に於いて、MTT活性率とは、試料無添加(コントロール)のMTT活性を100としたときの、各試料添加時のMTT活性の相対値を表す。
これに対して、比較例として実施した普通米の糠のエキス(比較製造例1)及びその発酵物(比較製造例2)にも、線維芽細胞を活性化する作用が僅かに認められたものの、その作用は本発明の試料より遙かに弱いものであった。
[result]
The results are shown in Table 1. In Table 1, the MTT activity rate represents the relative value of the MTT activity when each sample was added, where the MTT activity when no sample was added (control) was 100.
In contrast, the extract of common rice bran extracted as a comparative example (Comparative Production Example 1) and its fermented product (Comparative Production Example 2) also showed a slight activation of fibroblasts. The action was much weaker than that of the sample of the present invention.
試験例2.コラーゲン産生促進試験
試験例1と同様の試料(固形分濃度を1.0%としたもの)について、コラーゲン産生促進作用を調べた。
[試験方法]
ヒト皮膚真皮由来線維芽細胞NB1RGBを、0.5%NCS含有最小必須培地を入れた96穴マイクロプレートに1×104個/穴播種し、37℃で1日間プレ培養した後、培地に試料溶液を2.5又は5.0%の濃度(溶液濃度として)になるように添加して、37℃でさらに5日間培養した。
次に培養液を除去し、0.04%ファストグリーン、0,05%シリウスレッド溶液を添加し、細胞内のコラーゲン及び非コラーゲンを染色した後、充分に洗浄した。次に0.1%NaOH含有メタノールで抽出し、コラーゲン量を波長540nmで測定した。また、試験系が正常に機能しているかを確認するために、試験試料の代わりにL−アスコルビン酸−2−リン酸エステルマグネシウム(APM)を2mM添加した場合及び試料無添加の場合(コントロール)について同様の試験を行った。
結果は、試料無添加(コントロール)の場合の波長520nmに於ける吸光度を100としたときの各試料添加時の吸光度の相対値(コラーゲン合成率)を以て示した。
Test Example 2 Collagen production promotion test Collagen production promotion action was examined for the same sample as in Test Example 1 (solid content concentration 1.0%).
[Test method]
Human skin dermis-derived fibroblasts NB1RGB are seeded at 1 × 10 4 cells / well in a 96-well microplate containing 0.5% NCS-containing minimum essential medium, pre-cultured at 37 ° C. for 1 day, and then sampled in the medium The solution was added to a concentration of 2.5 or 5.0% (as a solution concentration) and cultured at 37 ° C. for another 5 days.
Next, the culture solution was removed, 0.04% fast green, 0.05% sirius red solution was added, and intracellular collagen and non-collagen were stained, and then washed thoroughly. Next, extraction was performed with 0.1% NaOH-containing methanol, and the amount of collagen was measured at a wavelength of 540 nm. Moreover, in order to confirm whether the test system is functioning normally, when 2 mM of L-ascorbic acid-2-phosphate magnesium (APM) is added instead of the test sample and when no sample is added (control) A similar test was conducted.
The results are shown as relative values (collagen synthesis rate) of the absorbance when each sample was added when the absorbance at a wavelength of 520 nm in the case where no sample was added (control) was taken as 100.
[結果]
結果を表2に示す。
The results are shown in Table 2.
表2に示すように、本発明の発芽玄米の糠のエキス(製造例1〜3)には、正常ヒト由来線維芽細胞におけるコラーゲン産生を顕著に亢進する効果が確認された。又、発芽玄米の糠エキスの酵素分解物(製造例6)及び発酵物(製造例8〜12)にも、上記エキスと同等のコラーゲン合成促進作用が認められた。
これに対して、普通米の糠のエキス(比較製造例1)及び発酵物(比較製造例2)の示すコラーゲン合成促進作用は本発明試料に遠く及ばないものであった。
As shown in Table 2, the effect of significantly enhancing collagen production in normal human-derived fibroblasts was confirmed in the germinated brown rice koji extract of the present invention (Production Examples 1 to 3). In addition, the enzyme degradation product (Production Example 6) and fermented product (Production Examples 8 to 12) of germinated brown rice koji extract showed the same collagen synthesis promoting action as the above extract.
On the other hand, the collagen synthesis promoting action of ordinary rice bran extract (Comparative Production Example 1) and fermented product (Comparative Production Example 2) was far from that of the sample of the present invention.
試験例3.皮膚刺激性
[試料]
(1)製造例1のエキスを日局親水ワセリンに5%の濃度となるように練合したもの(本発明試料1)
(2)製造例2のエキスを日局親水ワセリンに5%の濃度となるように練合したもの(本発明試料2)
(3)製造例6の酵素分解物溶液を日局親水ワセリンに5%の濃度となるように練合したもの(本発明試料3)
(4)製造例8の発酵物溶液を日局親水ワセリンに5%の濃度となるように練合したもの(本発明試料4)
(5)製造例12の発酵物溶液を日局親水ワセリンに5%の濃度となるように練合したもの(本発明試料5)
(6)日局親水ワセリン(対照)
Test Example 3 Skin irritation [sample]
(1) The kneaded extract of Production Example 1 in JP Hydrophilic Petrolatum to a concentration of 5% (Invention Sample 1)
(2) Kneaded extract of Production Example 2 to JP Hydrophilic Vaseline to a concentration of 5% (Invention Sample 2)
(3) A product obtained by kneading the enzyme degradation product solution of Production Example 6 with JP Vaseline to a concentration of 5% (Invention Sample 3)
(4) Kneaded fermented product solution of Production Example 8 in JP Hydrophilic Petrolatum to a concentration of 5% (Invention Sample 4)
(5) Kneaded fermented product solution of Production Example 12 in JP Hydrophilic Petrolatum to a concentration of 5% (Invention Sample 5)
(6) JP Hydrophilic Petrolatum (control)
[試験方法]
年齢20〜50歳の成人男子5名を被験者とし、各々の上腕部内側をエタノールで拭って皮脂を除去し、該部位に、フィンチャンバーのアルミ板に本発明試料1〜5及び対照の日局親水ワセリンをそれぞれ0.2g宛塗布したものを貼付した。24時間後にフィンチャンバーを除去し、皮膚刺激の程度をつぎに述べる方法並びに基準により判定した。
[判定]
パッチ除去後1時間後、24時間後及び48時間後に、貼付部位の紅斑及び浮腫の状況を、以下の「ドレイズ法による皮膚刺激性判定基準」に基づき目視判定し、被験者5名の平均値を求めた。
(紅斑)
スコア 皮膚の状態
0 : 紅斑なし
1 : 極軽度の紅斑
2 : 明らかな紅斑
3 : 中程度から強い紅斑
4 : 深紅色の強い紅斑に軽い痂皮形成
(浮腫)
スコア 皮膚の状態
0 : 浮腫なし
1 : 極軽度の浮腫
2 : 明らかな浮腫(周囲と明らかに区別可能)
3 : 中程度の浮腫(1mm以上の盛り上がり)
4 : 強い浮腫(さらに周囲にも広がり)
[Test method]
Five adult males aged 20 to 50 years were used as subjects, and the inner side of each upper arm was wiped with ethanol to remove sebum. What applied each 0.2g of hydrophilic petrolatum was stuck. After 24 hours, the fin chamber was removed, and the degree of skin irritation was determined by the method and criteria described below.
[Judgment]
After 1 hour, 24 hours and 48 hours after removing the patch, the state of erythema and edema at the applied site was visually determined based on the following “skin irritation criteria by dreze method”, and the average value of 5 subjects Asked.
(Erythema)
Score Skin condition 0: No erythema 1: Extremely mild erythema 2: Clear erythema 3: Moderate to strong erythema 4: Light crust formation in strong crimson erythema (edema)
Score Skin condition 0: No edema 1: Extremely mild edema 2: Clear edema (clearly distinguishable from surroundings)
3: Moderate edema (swelling of 1 mm or more)
4: Strong edema (further spread around)
結果を表3に示す。
表3の結果から明らかな通り、本発明の発芽玄米の糠のエキス、その酵素分解物及びその発酵物は、皮膚刺激がなく安全性に極めてすぐれている。 As apparent from the results in Table 3, the germinated brown rice bran extract of the present invention, its enzymatic degradation product and its fermented product have no skin irritation and are extremely safe.
試験例1.モニターテスト
実施例1及び4のクリームと比較実施例1及び2のクリームについて、モニターテストにより皮膚に対する効果を調べた。
[試験方法]
無作為に抽出した年齢18〜50歳の女性40名を被験者として20名ずつ2つのグループ(A、B)に分け、各グループに、実施例1と比較実施例1のクリーム又は実施例4と比較実施例2のクリームの2種の組み合わせのいずれかを割り振り、それぞれ左右の頬部に、実施例又は比較実施例のクリームを1日2回(朝、晩)、1ヵ月間塗布してもらった後、小ジワに対する改善効果及び肌のはり、艶に対する改善効果を、以下の評価基準に基づいて評価した。
Test Example 1 Monitor Test The effects of the creams of Examples 1 and 4 and the creams of Comparative Examples 1 and 2 on the skin were examined by a monitor test.
[Test method]
Randomly extracted 40 women aged 18-50 were divided into two groups (A, B) of 20 subjects as subjects, and each group was divided into Example 1 and Comparative Example 1 cream or Example 4. One of the two combinations of the cream of Comparative Example 2 was allocated, and the cream of the Example or Comparative Example was applied to the left and right cheeks twice a day (morning and evening) for one month. Then, the improvement effect with respect to fine wrinkles and the improvement effect with respect to skin tension and gloss were evaluated based on the following evaluation criteria.
[評価基準]
(小ジワに対する改善効果)
A:殆ど目立たなくなった
B:かなり目立たなくなった
C:わずかに目立たなくなった
D:変わらない
E:かえって増えた
(肌のはり、艶に対する改善効果)
A:明らかに改善された
B:かなり改善された
C:僅かに改善された
D:変わらない
E:かえって悪くなった
[Evaluation criteria]
(Improvement effect on small wrinkles)
A: Almost inconspicuous B: Almost inconspicuous C: Slightly inconspicuous D: Unchanged E: On the contrary (Improvement effect on skin elasticity and gloss)
A: Clearly improved B: Much improved C: Slightly improved D: No change E: On the contrary
[結果]
結果を表4に示す。なお、表中のA〜Eの各評価欄の数字は、被験者20名中当該評価を行った被験者の数を示す。
The results are shown in Table 4. In addition, the number of each evaluation column of AE in a table | surface shows the number of the test subjects who performed the said evaluation in 20 test subjects.
表4に示す通り、発芽玄米の糠のエキス或いはその発酵物を活性成分として配合してなる本発明のクリームは、皮膚の老化或いは不健全化の典型的な症状であるシワ、たるみ等に対してすぐれた改善作用を示す。
これに対して、普通米の糠のエキス或いはその発酵物を配合した比較実施例のクリームでは、殆ど改善効果が見られず、明らかに有効性に違いがある結果となった。
As shown in Table 4, the cream of the present invention comprising an extract of germinated brown rice bran extract or a fermented product thereof as an active ingredient prevents wrinkles, sagging, etc., which are typical symptoms of aging or unhealthy skin. Excellent improvement effect.
On the other hand, in the cream of the comparative example which mix | blended the extract of the common rice bran, or its fermented product, the improvement effect was hardly seen but it resulted in a difference in effectiveness clearly.
Claims (3)
A rice bran or extract thereof mainly composed of germ and endosperm shell obtained by polishing germinated brown rice into a germinated rice is at least one selected from lactic acid bacteria, koji molds, yeast, natto bacteria, and tempeh bacteria. A cosmetic comprising a fermented product obtained by fermentation.
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JP2009183276A (en) * | 2007-07-13 | 2009-08-20 | Akita Univ | Rice bran leachate having enzyme activity, product obtained from the same rice bran leachate, and method for producing the same |
KR101259589B1 (en) * | 2010-10-25 | 2013-04-30 | 경상북도(농업기술원) | A method of making fermented rice extract for inhibiting skin aging, fermented rice extract obtained therefrom and a skin-aging inhibiting cosmetic composition containing the extract |
CN103841956B (en) * | 2011-03-27 | 2016-11-09 | 奥麒化工有限公司 | Regulation epigenetic DNA methylation is to cause cell to take the DNA methylation pattern relevant to young cell |
JP5773356B2 (en) * | 2011-05-20 | 2015-09-02 | 共栄化学工業株式会社 | Cosmetics |
JP5403638B2 (en) * | 2011-12-26 | 2014-01-29 | 敏 新川 | Composition exhibiting collagen producing action |
KR101403523B1 (en) * | 2012-02-22 | 2014-06-11 | 이은영 | Making Method of Facial moisturizer. |
JP6474186B2 (en) * | 2012-11-26 | 2019-02-27 | 共栄化学工業株式会社 | Cosmetics |
JP6718202B2 (en) * | 2014-06-20 | 2020-07-08 | 共栄化学工業株式会社 | Topical skin |
JP7025113B2 (en) * | 2016-04-19 | 2022-02-24 | 株式会社テクノーブル | Cosmetics |
JP6662726B2 (en) * | 2016-06-28 | 2020-03-11 | 株式会社ファンケル | Germinated brown rice Saccharomyces verona fermented liquid |
KR20180064185A (en) * | 2016-12-05 | 2018-06-14 | 유한회사 아이에스티케이3 | Process for producing fermented rice bran lactic acid bacteria fermentation liquid and The cosmetic composition containing the same |
JP2019014669A (en) * | 2017-07-05 | 2019-01-31 | 共栄化学工業株式会社 | External composition for skin |
CN108324633B (en) * | 2018-03-01 | 2021-08-13 | 华熙生物科技股份有限公司 | Preparation method of brown rice fermentation stock solution for cosmetics and product thereof |
JP6651084B1 (en) | 2018-04-10 | 2020-02-19 | 株式会社Stardust Hd. | Composition containing extract of yuzu seed and brown rice |
KR102096444B1 (en) * | 2018-10-08 | 2020-04-03 | 선문대학교 산학협력단 | A cosmetic compositon comprising rice bran protein |
JP7382622B2 (en) * | 2019-05-13 | 2023-11-17 | 株式会社東洋新薬 | Composition |
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