JP4615315B2 - 内皮依存性血管作用を決定するための方法 - Google Patents
内皮依存性血管作用を決定するための方法 Download PDFInfo
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- JP4615315B2 JP4615315B2 JP2004558325A JP2004558325A JP4615315B2 JP 4615315 B2 JP4615315 B2 JP 4615315B2 JP 2004558325 A JP2004558325 A JP 2004558325A JP 2004558325 A JP2004558325 A JP 2004558325A JP 4615315 B2 JP4615315 B2 JP 4615315B2
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43173902P | 2002-12-09 | 2002-12-09 | |
| PCT/IL2003/001025 WO2004052196A1 (en) | 2002-12-09 | 2003-12-03 | Method for determining endothelial dependent vasoactivity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006516000A JP2006516000A (ja) | 2006-06-15 |
| JP2006516000A5 JP2006516000A5 (https=) | 2007-01-25 |
| JP4615315B2 true JP4615315B2 (ja) | 2011-01-19 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004558325A Expired - Fee Related JP4615315B2 (ja) | 2002-12-09 | 2003-12-03 | 内皮依存性血管作用を決定するための方法 |
Country Status (8)
| Country | Link |
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| US (2) | US7374541B2 (https=) |
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Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60333120D1 (de) * | 2002-12-09 | 2010-08-05 | Univ Ramot | Verfahren zur bestimmung derendothel-abhängigen vasoaktivität |
| US7771364B2 (en) | 2004-01-27 | 2010-08-10 | Spirocor Ltd. | Method and system for cardiovascular system diagnosis |
| US7131949B2 (en) * | 2004-04-13 | 2006-11-07 | Omron Healthcare Co., Ltd. | Method and apparatus for examining vascular endothelial functions |
| US7664551B2 (en) * | 2004-07-07 | 2010-02-16 | Medtronic Transneuronix, Inc. | Treatment of the autonomic nervous system |
| EP1785088A1 (en) * | 2005-11-14 | 2007-05-16 | Congener Wellness Corp. | A system and method for the management and control of cardiovascular related diseases, such as hypertension |
| RU2309668C1 (ru) | 2006-02-20 | 2007-11-10 | Александр Сергеевич Парфенов | Способ неинвазивного определения функции эндотелия и устройство для его осуществления |
| JP4802324B2 (ja) * | 2006-02-22 | 2011-10-26 | 国立大学法人 名古屋工業大学 | 脈診解析のための脈波測定装置 |
| US7894900B2 (en) * | 2006-08-30 | 2011-02-22 | Smartimplant OÜ | Device and method for monitoring cardiac pacing rate |
| EP2096994B1 (en) | 2006-12-09 | 2018-10-03 | Masimo Corporation | Plethysmograph variability determination |
| US8100834B2 (en) * | 2007-02-27 | 2012-01-24 | J&M Shuler, Inc. | Method and system for monitoring oxygenation levels of a compartment for detecting conditions of a compartment syndrome |
| EP2163202A4 (en) * | 2007-06-04 | 2013-10-30 | Panasonic Corp | ULTRASONIC DIAGNOSTICS AND ULTRASONIC SOUND FOR ULTRASONIC DIAGNOSTICS |
| JP2009178456A (ja) * | 2008-01-31 | 2009-08-13 | Nippon Koden Corp | 自律神経活動計測装置及び計測方法 |
| JP5192859B2 (ja) * | 2008-03-17 | 2013-05-08 | 株式会社ユネクス | 生体血管状態測定装置 |
| US20110301500A1 (en) * | 2008-10-29 | 2011-12-08 | Tim Maguire | Automated vessel puncture device using three-dimensional(3d) near infrared (nir) imaging and a robotically driven needle |
| JP5167156B2 (ja) * | 2009-01-19 | 2013-03-21 | 株式会社デンソー | 生体状態評価装置、生体状態評価システム、プログラム、及び記録媒体 |
| US8057400B2 (en) * | 2009-05-12 | 2011-11-15 | Angiologix, Inc. | System and method of measuring changes in arterial volume of a limb segment |
| ITPI20090099A1 (it) * | 2009-07-31 | 2011-02-01 | Cnr Consiglio Naz Delle Ric Erche | Apparecchiatura per la misura della velocità di propagazione di un'onda pressoria nel sistema arterioso |
| US8668649B2 (en) * | 2010-02-04 | 2014-03-11 | Siemens Medical Solutions Usa, Inc. | System for cardiac status determination |
| GB2478291A (en) * | 2010-03-02 | 2011-09-07 | Univ Lancaster | Endothelium assessment probe |
| US9307928B1 (en) | 2010-03-30 | 2016-04-12 | Masimo Corporation | Plethysmographic respiration processor |
| JP5518554B2 (ja) * | 2010-04-16 | 2014-06-11 | 酒井医療株式会社 | 血管硬さ評価システム及び血管硬さ指標の算出方法 |
| WO2012021765A2 (en) * | 2010-08-12 | 2012-02-16 | Board Of Trustees Of Michigan State University | Methods and apparatus for determining arterial pulse wave velocity |
| US9320445B2 (en) | 2011-05-17 | 2016-04-26 | Siemens Medical Solutions Usa, Inc. | System for cardiac condition detection responsive to blood pressure analysis |
| US10398323B2 (en) * | 2012-08-28 | 2019-09-03 | Board Of Trustees Of Michigan State University | Methods and apparatus for determining pulse transit time as a function of blood pressure |
| JP5571234B2 (ja) * | 2013-06-26 | 2014-08-13 | 日本光電工業株式会社 | 自律神経活動計測装置 |
| JP6349075B2 (ja) | 2013-11-22 | 2018-06-27 | 三星電子株式会社Ｓａｍｓｕｎｇ Ｅｌｅｃｔｒｏｎｉｃｓ Ｃｏ．，Ｌｔｄ． | 心拍数測定装置及び心拍数測定方法 |
| US10945612B2 (en) | 2014-04-03 | 2021-03-16 | The Regents Of The University Of California | Assessing endothelial function using a blood pressure cuff |
| US10105089B2 (en) | 2014-06-18 | 2018-10-23 | Hong Kong Applied Science And Technology Research Institute Co., Ltd. | Systems and methods for blood pressure measurement with psychological status validation |
| US10588577B2 (en) | 2015-01-29 | 2020-03-17 | Siemens Healthcare Gmbh | Patient signal analysis based on affine template matching |
| US9737217B2 (en) * | 2015-08-14 | 2017-08-22 | The Regents Of The University Of California | Assessing endothelial function and providing calibrated UFMD data using a blood pressure cuff |
| KR20190094214A (ko) | 2016-12-15 | 2019-08-12 | 백스터 인터내셔널 인코포레이티드 | 감지된 정맥 파형으로부터 환자 파라미터들을 모니터링하고 결정하기 위한 시스템 및 방법 |
| US20180192916A1 (en) * | 2017-01-10 | 2018-07-12 | General Electric Company | Imaging system for diagnosing patient condition |
| US11039754B2 (en) | 2018-05-14 | 2021-06-22 | Baxter International Inc. | System and method for monitoring and determining patient parameters from sensed venous waveform |
| EP3782542B1 (en) * | 2019-08-20 | 2024-04-10 | Stichting IMEC Nederland | A method and system for microcirculation function assessment |
| JP7560822B2 (ja) * | 2020-02-25 | 2024-10-03 | 日本光電工業株式会社 | 生体情報処理装置、生体情報処理方法、プログラム及び記憶媒体 |
| RU2751817C1 (ru) * | 2020-08-31 | 2021-07-19 | Закрытое Акционерное Общество "Ес-Лизинг" | Компьютеризированный способ неинвазивного выявления нарушений углеводного обмена по вариабельности сердечного ритма и носимое автономное устройство для его реализации |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3623476A (en) * | 1970-02-16 | 1971-11-30 | Philips Corp | Blood pressure measurement apparatus |
| US5111826A (en) * | 1984-12-07 | 1992-05-12 | Nasiff Roger E | Indirect continuous blood pressure method |
| JP2979933B2 (ja) * | 1993-08-03 | 1999-11-22 | セイコーエプソン株式会社 | 脈波解析装置 |
| JPH08266489A (ja) * | 1995-03-29 | 1996-10-15 | Nippon Ham Kk | 動脈硬化部位の検出方法 |
| JPH11128185A (ja) * | 1997-10-31 | 1999-05-18 | Matsushita Electric Ind Co Ltd | 心拍変動解析方法および装置 |
| IL124787A0 (en) * | 1998-06-07 | 1999-01-26 | Itamar Medical C M 1997 Ltd | Pressure applicator devices particularly useful for non-invasive detection of medical conditions |
| IL128482A (en) | 1999-02-11 | 2003-06-24 | Ultrasis Internat 1993 Ltd | Method and device for continuous analysis of cardiovascular activity of a subject |
| JP3027750B1 (ja) | 1999-05-17 | 2000-04-04 | 日本コーリン株式会社 | 下肢上肢血圧指数測定装置および下肢血圧測定装置 |
| US6616613B1 (en) * | 2000-04-27 | 2003-09-09 | Vitalsines International, Inc. | Physiological signal monitoring system |
| NZ524765A (en) * | 2000-07-19 | 2006-10-27 | Nigel E Sharrock | Non-invasive measurement of suprasystolic signals |
| WO2002034105A2 (en) | 2000-10-23 | 2002-05-02 | Itamar Medical Ltd. | Non-invasive endothelial activity evaluation |
| JP3590583B2 (ja) * | 2000-12-28 | 2004-11-17 | フクダ電子株式会社 | 血管内皮機能測定装置 |
| US20020149152A1 (en) | 2001-02-23 | 2002-10-17 | Alan Taylor | Multiple-stage game of chance and method of and system for playing the game |
| JP2002253519A (ja) * | 2001-03-01 | 2002-09-10 | Nippon Koden Corp | 血液量測定方法及び生体信号モニタ装置 |
| JP2002291709A (ja) | 2001-03-30 | 2002-10-08 | Nippon Colin Co Ltd | 圧脈波検出装置 |
| JP3533406B2 (ja) | 2001-07-02 | 2004-05-31 | コーリンメディカルテクノロジー株式会社 | 動脈硬化評価装置 |
| GB0205653D0 (en) | 2002-03-11 | 2002-04-24 | Micro Medical Ltd | A method of measuring endothelial function in a person |
| DE60333120D1 (de) | 2002-12-09 | 2010-08-05 | Univ Ramot | Verfahren zur bestimmung derendothel-abhängigen vasoaktivität |
| US20060195035A1 (en) * | 2005-02-28 | 2006-08-31 | Dehchuan Sun | Non-invasive radial artery blood pressure waveform measuring apparatus system and uses thereof |
| JP4752673B2 (ja) * | 2005-10-06 | 2011-08-17 | コニカミノルタセンシング株式会社 | 脈波データ解析方法、システム、プログラム |
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- 2003-12-03 EP EP03812666A patent/EP1569550B1/en not_active Expired - Lifetime
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- 2003-12-03 WO PCT/IL2003/001025 patent/WO2004052196A1/en not_active Ceased
- 2003-12-03 JP JP2004558325A patent/JP4615315B2/ja not_active Expired - Fee Related
- 2003-12-03 CA CA002508590A patent/CA2508590A1/en not_active Abandoned
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| Publication number | Publication date |
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| CA2508590A1 (en) | 2004-06-24 |
| US7374541B2 (en) | 2008-05-20 |
| AU2003302882A1 (en) | 2004-06-30 |
| AU2003302882B2 (en) | 2008-06-19 |
| ATE471692T1 (de) | 2010-07-15 |
| EP1569550B1 (en) | 2010-06-23 |
| EP1569550A1 (en) | 2005-09-07 |
| JP2006516000A (ja) | 2006-06-15 |
| US8187196B2 (en) | 2012-05-29 |
| US20080200820A1 (en) | 2008-08-21 |
| US20060149152A1 (en) | 2006-07-06 |
| DE60333120D1 (de) | 2010-08-05 |
| WO2004052196A1 (en) | 2004-06-24 |
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