JP4583372B2 - 検査領域内における非凝集状態の磁性粒子の空間的な分布の、改善された特定のための方法および装置 - Google Patents

検査領域内における非凝集状態の磁性粒子の空間的な分布の、改善された特定のための方法および装置 Download PDF

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JP4583372B2
JP4583372B2 JP2006506855A JP2006506855A JP4583372B2 JP 4583372 B2 JP4583372 B2 JP 4583372B2 JP 2006506855 A JP2006506855 A JP 2006506855A JP 2006506855 A JP2006506855 A JP 2006506855A JP 4583372 B2 JP4583372 B2 JP 4583372B2
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magnetic field
magnetic
particles
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magnetization
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JP2006523496A (ja
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ベルンハルド グレイヒ
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Koninklijke Philips NV
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/0515—Magnetic particle imaging

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Radiology & Medical Imaging (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
JP2006506855A 2003-04-15 2004-04-15 検査領域内における非凝集状態の磁性粒子の空間的な分布の、改善された特定のための方法および装置 Expired - Fee Related JP4583372B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03101019 2003-04-15
PCT/IB2004/050450 WO2004091398A2 (en) 2003-04-15 2004-04-15 Method and apparatus for improved determination of spatial non-agglomerated magnetic particle distribution in an area of examination

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JP2006523496A JP2006523496A (ja) 2006-10-19
JP4583372B2 true JP4583372B2 (ja) 2010-11-17

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JP2006506855A Expired - Fee Related JP4583372B2 (ja) 2003-04-15 2004-04-15 検査領域内における非凝集状態の磁性粒子の空間的な分布の、改善された特定のための方法および装置

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US (1) US20060248945A1 (de)
EP (1) EP1615557B1 (de)
JP (1) JP4583372B2 (de)
WO (1) WO2004091398A2 (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060248944A1 (en) * 2003-04-15 2006-11-09 Koninklijke Philips Electronics N.V. Method to determine the spatial distribution of magnetic particles and magnetic particle administering compositions
US20070003977A1 (en) 2003-08-20 2007-01-04 Amorfix Life Sciences Ltd Epitope protection assay and method for detecting protein conformations
US7482807B2 (en) * 2004-09-28 2009-01-27 Koninklijke Philips Electronics N.V. Method of determining a spatial distribution of magnetic particles
US7794692B2 (en) 2005-12-02 2010-09-14 Amorfix Life Sciences Ltd. Methods and compositions for detecting amyotrophic lateral sclerosis
US7887803B2 (en) 2005-12-02 2011-02-15 Amorfix Life Sciences Methods and compositions to treat misfolded-SOD1 mediated diseases
EP1989308B1 (de) 2006-03-03 2017-05-31 ProMIS Neurosciences Inc. Verfahren und zusammensetzungen zum behandeln und erkennen von missgefaltetem sod1-herbeigeführte erkrankungen
WO2008078276A1 (en) * 2006-12-20 2008-07-03 Philips Intellectual Property & Standards Gmbh Arrangement and method for detecting and/or locating a magnetic material in a region of action, use of an arrangement in the examination of buildings
CN101563164B (zh) * 2006-12-20 2012-06-13 皇家飞利浦电子股份有限公司 用于分离磁性粒子的方法和设备、磁性粒子以及磁性粒子的用途
DE102007009210A1 (de) * 2007-02-26 2008-08-28 Siemens Ag Bildgebendes tomographisches Verfahren und zugehörige Anordnung
JP5100212B2 (ja) 2007-06-15 2012-12-19 株式会社東芝 磁性微粒子イメージング装置、検出コイル配設方法および磁束検出装置
EP2231273A2 (de) * 2007-12-13 2010-09-29 Koninklijke Philips Electronics N.V. Anordnung und verfahren zur beeinflussung und/oder erkennung magnetischer partikel in einem wirkungsbereich
RU2524974C2 (ru) * 2008-12-12 2014-08-10 Конинклейке Филипс Электроникс Н.В. Устройство и способ измерения локальной скорости жидкости
RU2542780C2 (ru) 2009-07-20 2015-02-27 Конинклейке Филипс Электроникс Н.В. Устройство и способ для оказания влияния и обнаружения магнитных частиц
CN102469952B (zh) 2009-08-07 2014-11-12 皇家飞利浦电子股份有限公司 用于确定至少一个电磁量的设备和方法
RU2570288C2 (ru) 2009-08-21 2015-12-10 Конинклейке Филипс Электроникс Н.В. Устройство и способ генерации и перемещения магнитного поля, имеющего линию отсутствия поля
WO2011024137A1 (en) 2009-08-31 2011-03-03 Koninklijke Philips Electronics N.V. Multi-level inverter apparatus and inversion method
US9192320B2 (en) 2009-09-11 2015-11-24 Koninklijke Philips N.V. Apparatus and method for influencing and/or detecting magnetic particles in a field of view
RU2552689C2 (ru) * 2009-09-11 2015-06-10 Конинклейке Филипс Электроникс Н.В. Устройство и способ для воздействия на магнитные частицы и/или их выявления
WO2011030249A1 (en) 2009-09-14 2011-03-17 Koninklijke Philips Electronics N.V. Apparatus and method for measuring the internal pressure of an examination object
EP2477540B1 (de) 2009-09-14 2015-02-25 Koninklijke Philips N.V. Vorrichtung und verfahren für nicht-invasive intrakardiale elektrokardiografie mit mpi
EP2477542B1 (de) 2009-09-14 2016-04-13 Koninklijke Philips N.V. Vorrichtung und verfahren zur steuerung der bewegung und zur positionsbestimmung eines katheters
BR112012019482A2 (pt) 2010-02-08 2018-07-24 Koninl Philips Electronics Nv aparelho para influenciar e\ou detectar partículas magnéticas em um campo de visão, metodo para influenciar e/ou detectar partículas magneticas em um campo de visão e programa de computador
WO2011095924A1 (en) 2010-02-08 2011-08-11 Koninklijke Philips Electronics N.V. Apparatus and method for detecting magnetic particles
WO2011121511A1 (en) 2010-04-01 2011-10-06 Koninklijke Philips Electronics N.V. Apparatus and method for forming a concentration image of the concentration of magnetic particles arranged in a field of view field of the invention
WO2011121487A1 (en) 2010-04-01 2011-10-06 Koninklijke Philips Electronics N.V. Apparatus and method for forming a concentration image of the concentration of magnetic particles arranged in a field of view
WO2012007871A1 (en) 2010-07-13 2012-01-19 Koninklijke Philips Electronics N.V. System and method for generating a system function for use in the reconstruction of images
WO2012046157A1 (en) 2010-10-05 2012-04-12 Koninklijke Philips Electronics N.V. Apparatus and method for locating magnetic particles
EP2648611B1 (de) 2010-12-10 2015-02-25 Koninklijke Philips N.V. Vorrichtung und verfahren zur beeinflussung und/oder erkennung magnetischer partikel
BR112013013882A2 (pt) 2010-12-10 2016-09-13 Koninkl Philips Electronics Nv aparelho para operação em um modo de imagem da partículas magnética para influenciar e/ou detectar partículas magnéticas em um campo de visão e para operação em um modo de imagem de ressonância magnética, método para operar um aparelho e programa de computador
WO2012122216A1 (en) * 2011-03-07 2012-09-13 Yadong Yin Magnetically responsive photonic nanochains
BR112014011533A2 (pt) 2011-11-16 2017-05-09 Koninklijke Philips Nv aparelho de influência e/ou detecção de partículas magnéticas em um campo de visão
EP2748623B1 (de) 2011-12-02 2016-09-07 Koninklijke Philips N.V. Spulenanordnung für mpi
BR112014014284A2 (pt) 2011-12-15 2017-06-13 Koninklijke Philips Nv aparelho e método para detecção de partículas magnéticas em um campo de visão, e, programa de computador
WO2013114247A2 (en) 2012-02-01 2013-08-08 Koninklijke Philips N.V. Multimodal fiducial marker and marker arrangement
WO2014057396A1 (en) 2012-10-12 2014-04-17 Koninklijke Philips N.V. Dynamic background correction in mpi
EP2916731A1 (de) 2012-11-07 2015-09-16 Koninklijke Philips N.V. Magnetische vorrichtung zur verwendung in einer mpi-vorrichtung
EP2994769A4 (de) * 2013-03-21 2017-03-01 Weinberg Medical Physics LLC Verfahren und vorrichtung für hochauflösende physiologische bildgebung von neuronen
WO2014147589A1 (en) 2013-03-21 2014-09-25 Koninklijke Philips N.V. Apparatus and method for influencing and/or detecting magnetic particles comprising compensation unit
EP3043703A1 (de) 2013-09-11 2016-07-20 Koninklijke Philips N.V. Mpi-vorrichtung mit schneller sichtfeldbewegung
JP5815902B1 (ja) 2014-05-14 2015-11-17 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． ブリッジユニットを有し、磁性粒子に影響を与える及び／又は検出する装置及び方法
WO2016023743A2 (en) * 2014-08-13 2016-02-18 Koninklijke Philips N.V. Apparatus and method for targeted drug delivery
PL3198348T3 (pl) 2014-09-24 2020-10-05 Quantum Valley Investment Fund LP Generowanie sekwencji sterującej do sterowania kwantowego
WO2016054518A1 (en) * 2014-10-02 2016-04-07 Weinberg Medical Physics Llc Pulsed gradient field method to counteract a static magnetic field for magnetic particle focusing
CN104473642B (zh) * 2014-11-27 2016-08-31 华中科技大学 一种基于磁纳米粒子交流磁化率虚部的成像方法
WO2017032903A1 (en) 2015-08-27 2017-03-02 Koninklijke Philips N.V. Magnet arrangement and magnetic particle imaging device
CN112513660A (zh) 2018-07-25 2021-03-16 量子谷投资基金有限合伙公司 非线性共振器的模型不敏感控制

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2365178C2 (de) * 1973-12-29 1982-07-01 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von magnetischen Materialien mit Austauschanisotropieverhalten
US4849210A (en) * 1985-05-08 1989-07-18 Molecular Biosystems, Inc. Magnetic resonance imaging of liver and spleen with superparamagnetic contrast agents
US5597531A (en) * 1985-10-04 1997-01-28 Immunivest Corporation Resuspendable coated magnetic particles and stable magnetic particle suspensions
US5122418A (en) * 1985-12-09 1992-06-16 Shiseido Company Ltd. Composite powder and production process
US4827945A (en) * 1986-07-03 1989-05-09 Advanced Magnetics, Incorporated Biologically degradable superparamagnetic materials for use in clinical applications
US5370901A (en) * 1991-02-15 1994-12-06 Bracco International B.V. Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients
US6726650B2 (en) * 1997-12-04 2004-04-27 Bracco Research S.A. Automatic liquid injection system and method
US6056872A (en) * 1998-02-06 2000-05-02 The Magnetizer Group, Inc. Magnetic device for the treatment of fluids
WO2000009170A1 (en) * 1998-08-10 2000-02-24 Bracco Research S.A. Combination of a positive mri contrast agent with a negative mri contrast agent
ES2315238T3 (es) * 1999-07-19 2009-04-01 Biomerieux B.V. Metodo para mezclar particulas magneticas con un fluido.
US7731648B2 (en) * 2001-07-25 2010-06-08 Aduro Biotech Magnetic nanoscale particle compositions, and therapeutic methods related thereto
DE10151778A1 (de) * 2001-10-19 2003-05-08 Philips Corp Intellectual Pty Verfahren zur Ermittlung der räumlichen Verteilung magnetischer Partikel
GB0130284D0 (en) * 2001-12-19 2002-02-06 Glaxo Group Ltd Medicament dispenser
DE10238853A1 (de) * 2002-08-24 2004-03-04 Philips Intellectual Property & Standards Gmbh Verfahren zur lokalen Erwärmung mit magnetischen Partikeln
US7351194B2 (en) * 2003-04-15 2008-04-01 Koninklijke Philips Electronics N.V. Arrangement for influencing magnetic particles
WO2004091390A2 (en) * 2003-04-15 2004-10-28 Philips Intellectual Property & Standards Gmbh Device and method for examination and use of an electrical field in an object under examination containing magnetic particles
EP1615544B1 (de) * 2003-04-15 2012-02-01 Philips Intellectual Property & Standards GmbH Anordnung sowie verfahren zur räumlich aufgelösten bestimmung von zustandsgrössen in einem untersuchungsbereich

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Publication number Publication date
EP1615557B1 (de) 2012-09-19
WO2004091398A3 (en) 2005-03-17
WO2004091398A2 (en) 2004-10-28
JP2006523496A (ja) 2006-10-19
US20060248945A1 (en) 2006-11-09
EP1615557A2 (de) 2006-01-18

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