JP4550051B2 - 全身性エリテマトーデスの同定およびモニタリング - Google Patents
全身性エリテマトーデスの同定およびモニタリング Download PDFInfo
- Publication number
- JP4550051B2 JP4550051B2 JP2006513114A JP2006513114A JP4550051B2 JP 4550051 B2 JP4550051 B2 JP 4550051B2 JP 2006513114 A JP2006513114 A JP 2006513114A JP 2006513114 A JP2006513114 A JP 2006513114A JP 4550051 B2 JP4550051 B2 JP 4550051B2
- Authority
- JP
- Japan
- Prior art keywords
- individual
- complement
- bound
- lupus erythematosus
- systemic lupus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000012544 monitoring process Methods 0.000 title claims abstract description 15
- 201000000596 systemic lupus erythematosus Diseases 0.000 title claims description 103
- 238000000034 method Methods 0.000 claims abstract description 58
- 230000000295 complement effect Effects 0.000 claims abstract description 10
- 108010042293 complement C4d Proteins 0.000 claims description 75
- 230000027455 binding Effects 0.000 claims description 22
- 230000009266 disease activity Effects 0.000 claims description 22
- 101001070790 Homo sapiens Platelet glycoprotein Ib alpha chain Proteins 0.000 claims description 19
- 102100034173 Platelet glycoprotein Ib alpha chain Human genes 0.000 claims description 19
- 238000000684 flow cytometry Methods 0.000 claims description 17
- 238000011002 quantification Methods 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 2
- 238000002372 labelling Methods 0.000 claims 7
- 210000001772 blood platelet Anatomy 0.000 description 75
- 201000010099 disease Diseases 0.000 description 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 15
- 230000037361 pathway Effects 0.000 description 14
- 239000000306 component Substances 0.000 description 12
- 238000003556 assay Methods 0.000 description 11
- 206010025135 lupus erythematosus Diseases 0.000 description 11
- 239000000523 sample Substances 0.000 description 11
- 210000004369 blood Anatomy 0.000 description 8
- 239000008280 blood Substances 0.000 description 8
- 208000024891 symptom Diseases 0.000 description 8
- 238000003745 diagnosis Methods 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 239000012634 fragment Substances 0.000 description 7
- 206010015150 Erythema Diseases 0.000 description 5
- 241000219061 Rheum Species 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 210000000056 organ Anatomy 0.000 description 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 4
- 230000000875 corresponding effect Effects 0.000 description 4
- 230000014509 gene expression Effects 0.000 description 4
- 238000010166 immunofluorescence Methods 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 238000003127 radioimmunoassay Methods 0.000 description 4
- 238000002965 ELISA Methods 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 238000001994 activation Methods 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 230000024203 complement activation Effects 0.000 description 3
- 102000006834 complement receptors Human genes 0.000 description 3
- 108010047295 complement receptors Proteins 0.000 description 3
- 230000008021 deposition Effects 0.000 description 3
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
- 210000003743 erythrocyte Anatomy 0.000 description 3
- 210000004408 hybridoma Anatomy 0.000 description 3
- 210000004789 organ system Anatomy 0.000 description 3
- 239000002953 phosphate buffered saline Substances 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 2
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 2
- 208000024827 Alzheimer disease Diseases 0.000 description 2
- 208000023275 Autoimmune disease Diseases 0.000 description 2
- 108090001008 Avidin Proteins 0.000 description 2
- 108010078015 Complement C3b Proteins 0.000 description 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 102000003992 Peroxidases Human genes 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 208000001647 Renal Insufficiency Diseases 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 208000007502 anemia Diseases 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 229960002685 biotin Drugs 0.000 description 2
- 235000020958 biotin Nutrition 0.000 description 2
- 239000011616 biotin Substances 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 208000037976 chronic inflammation Diseases 0.000 description 2
- 230000006020 chronic inflammation Effects 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- 206010016256 fatigue Diseases 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 201000006370 kidney failure Diseases 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- 108040007629 peroxidase activity proteins Proteins 0.000 description 2
- 230000000644 propagated effect Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- 239000012103 Alexa Fluor 488 Substances 0.000 description 1
- 201000004384 Alopecia Diseases 0.000 description 1
- 102000013455 Amyloid beta-Peptides Human genes 0.000 description 1
- 108010090849 Amyloid beta-Peptides Proteins 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- 108010069112 Complement System Proteins Proteins 0.000 description 1
- 102000000989 Complement System Proteins Human genes 0.000 description 1
- 101710137943 Complement control protein C3 Proteins 0.000 description 1
- 206010012289 Dementia Diseases 0.000 description 1
- 201000010374 Down Syndrome Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 208000031220 Hemophilia Diseases 0.000 description 1
- 208000009292 Hemophilia A Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 description 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 description 1
- 102000004856 Lectins Human genes 0.000 description 1
- 108090001090 Lectins Proteins 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 208000034486 Multi-organ failure Diseases 0.000 description 1
- 208000010718 Multiple Organ Failure Diseases 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 206010068786 Overlap syndrome Diseases 0.000 description 1
- 206010034960 Photophobia Diseases 0.000 description 1
- 101710132637 Protein C2 Proteins 0.000 description 1
- 101710132632 Protein C4 Proteins 0.000 description 1
- 201000004681 Psoriasis Diseases 0.000 description 1
- 208000003782 Raynaud disease Diseases 0.000 description 1
- 208000012322 Raynaud phenomenon Diseases 0.000 description 1
- 101710136899 Replication enhancer protein Proteins 0.000 description 1
- 102000012479 Serine Proteases Human genes 0.000 description 1
- 108010022999 Serine Proteases Proteins 0.000 description 1
- 208000021386 Sjogren Syndrome Diseases 0.000 description 1
- 201000009594 Systemic Scleroderma Diseases 0.000 description 1
- 206010042953 Systemic sclerosis Diseases 0.000 description 1
- 101710195626 Transcriptional activator protein Proteins 0.000 description 1
- 206010044688 Trisomy 21 Diseases 0.000 description 1
- 208000025851 Undifferentiated connective tissue disease Diseases 0.000 description 1
- 208000017379 Undifferentiated connective tissue syndrome Diseases 0.000 description 1
- 238000011497 Univariate linear regression Methods 0.000 description 1
- 208000024780 Urticaria Diseases 0.000 description 1
- 206010047115 Vasculitis Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000002744 anti-aggregatory effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 230000006472 autoimmune response Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000004154 complement system Effects 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 230000001086 cytosolic effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000008260 defense mechanism Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000009795 derivation Methods 0.000 description 1
- 201000001981 dermatomyositis Diseases 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- BFMYDTVEBKDAKJ-UHFFFAOYSA-L disodium;(2',7'-dibromo-3',6'-dioxido-3-oxospiro[2-benzofuran-1,9'-xanthene]-4'-yl)mercury;hydrate Chemical compound O.[Na+].[Na+].O1C(=O)C2=CC=CC=C2C21C1=CC(Br)=C([O-])C([Hg])=C1OC1=C2C=C(Br)C([O-])=C1 BFMYDTVEBKDAKJ-UHFFFAOYSA-L 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229940071106 ethylenediaminetetraacetate Drugs 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 238000001917 fluorescence detection Methods 0.000 description 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 1
- 208000024963 hair loss Diseases 0.000 description 1
- 230000003676 hair loss Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 208000007475 hemolytic anemia Diseases 0.000 description 1
- 208000010710 hepatitis C virus infection Diseases 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 239000002523 lectin Substances 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 230000002025 microglial effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000003068 molecular probe Substances 0.000 description 1
- 208000029744 multiple organ dysfunction syndrome Diseases 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 230000008816 organ damage Effects 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 208000005987 polymyositis Diseases 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 238000001338 self-assembly Methods 0.000 description 1
- 230000000405 serological effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 238000002562 urinalysis Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
- G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
- G01N2800/104—Lupus erythematosus [SLE]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/967—Standards, controls, materials, e.g. validation studies, buffer systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/973—Simultaneous determination of more than one analyte
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/821—Chemistry: analytical and immunological testing involving complement factors or complement systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/101666—Particle count or volume standard or control [e.g., platelet count standards, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Rheumatology (AREA)
- Rehabilitation Therapy (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Dc Digital Transmission (AREA)
- Small-Scale Networks (AREA)
- Testing Of Coins (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46344703P | 2003-04-16 | 2003-04-16 | |
| PCT/US2004/011982 WO2004093647A2 (en) | 2003-04-16 | 2004-04-16 | Identification and monitoring of systematic lupus erythematosus |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006524342A JP2006524342A (ja) | 2006-10-26 |
| JP2006524342A5 JP2006524342A5 (https=) | 2007-06-07 |
| JP4550051B2 true JP4550051B2 (ja) | 2010-09-22 |
Family
ID=33310779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006513114A Expired - Lifetime JP4550051B2 (ja) | 2003-04-16 | 2004-04-16 | 全身性エリテマトーデスの同定およびモニタリング |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US7588905B2 (https=) |
| EP (1) | EP1618379B1 (https=) |
| JP (1) | JP4550051B2 (https=) |
| AT (1) | ATE552501T1 (https=) |
| AU (1) | AU2004232007B2 (https=) |
| CA (1) | CA2522261A1 (https=) |
| WO (1) | WO2004093647A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA200510325B (en) | 2003-06-13 | 2008-04-30 | Univ Pittsburgh | Monitoring immunologic, hematologic and inflammatory diseases |
| US20080131914A1 (en) * | 2005-09-14 | 2008-06-05 | Ahearn Joseph M | Assessing risk of cerebrovascular thrombosis by measuring c4d |
| US8062852B2 (en) | 2007-10-01 | 2011-11-22 | The Children's Hospital And Regional Medical Center | Detection and treatment of autoimmune disorders |
| US20100233752A1 (en) * | 2008-10-16 | 2010-09-16 | Cypress Bioscience, Inc. | Method for diagnosis and monitoring of disease activity and response to treatment in systemic lupus erythematosus (sle) and other autoimmune diseases |
| JP5625155B2 (ja) * | 2010-07-30 | 2014-11-19 | 国立大学法人 東京大学 | ホスファチジルセリン特異的ホスホリパーゼａ１測定による全身性エリテマトーデスの検査方法および検査薬 |
| EP2673644B1 (en) | 2011-02-11 | 2016-02-10 | Exagen Diagnostics, Inc. | Methods for diagnosing systemic lupus erythematosus |
| RU2019103573A (ru) | 2013-02-08 | 2019-03-15 | Аллегени-Сингер Рисерч Инститьют | Клеточно-связанные продукты активации комплемента в качестве диагностических биомаркеров волчанки в доклинической стадии |
| US9863946B2 (en) | 2013-02-08 | 2018-01-09 | Allegheny-Singer Research Institute | Cell-bound complement activation products as diagnostic biomarkers for pre-lupus |
| WO2014151238A1 (en) | 2013-03-15 | 2014-09-25 | Exagen Diagnostics, Inc. | Methods for treating and diagnosing systemic lupus erythematosus |
| US10105413B2 (en) | 2013-06-13 | 2018-10-23 | Medical Research & Development Fund for Health Services Bnai Zion Medical Center | Semaphorin 3A for treatment of systemic lupus erythematosus |
| CA2990722C (en) | 2015-07-31 | 2022-07-05 | Allegheny-Singer Research Institute | Cell-bound complement activation product assays as companion diagnostics for antibody-based drugs |
| US12130288B2 (en) | 2016-05-24 | 2024-10-29 | Allegheny Singer Research Institute | Methods and systems using C4 gene copy number and cell-bound complement activation products for identification of lupus and pre-lupus |
| CA3203051A1 (en) * | 2020-12-21 | 2022-06-30 | Zaverio M. Ruggeri | Method for evaluating blood parameters |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0666987A4 (en) | 1992-10-30 | 1997-08-27 | T Cell Diagnostics Inc | EVALUATION OF THE TOTAL QUANTITY OF A MOLECULE IN A SAMPLE AND METHODS BASED ON SAME. |
| WO1999045094A1 (en) * | 1998-03-02 | 1999-09-10 | Compucyte Corp. | Selective cell analysis |
| JP4570872B2 (ja) * | 2001-09-10 | 2010-10-27 | ユニヴァーシティ オブ ピッツバーグ | 全身性紅斑性狼瘡および強皮症の診断およびモニタリング方法 |
| ZA200510325B (en) * | 2003-06-13 | 2008-04-30 | Univ Pittsburgh | Monitoring immunologic, hematologic and inflammatory diseases |
| EP1756571B8 (en) * | 2004-04-09 | 2010-10-13 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Real time method of detecting acute inflammatory conditions |
| CA2564492C (en) * | 2004-05-11 | 2012-05-22 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Diagnosing and monitoring inflammatory diseases by measuring complement components on white blood cells |
| US7679298B2 (en) * | 2006-08-17 | 2010-03-16 | General Electric Company | Locomotive wheel speed control |
-
2004
- 2004-04-16 AU AU2004232007A patent/AU2004232007B2/en not_active Ceased
- 2004-04-16 AT AT04759986T patent/ATE552501T1/de active
- 2004-04-16 EP EP04759986A patent/EP1618379B1/en not_active Expired - Lifetime
- 2004-04-16 WO PCT/US2004/011982 patent/WO2004093647A2/en not_active Ceased
- 2004-04-16 US US10/552,177 patent/US7588905B2/en not_active Expired - Lifetime
- 2004-04-16 JP JP2006513114A patent/JP4550051B2/ja not_active Expired - Lifetime
- 2004-04-16 CA CA002522261A patent/CA2522261A1/en not_active Abandoned
-
2009
- 2009-08-07 US US12/538,001 patent/US8126654B2/en not_active Expired - Lifetime
-
2012
- 2012-01-25 US US13/358,428 patent/US20120122241A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20120122241A1 (en) | 2012-05-17 |
| US8126654B2 (en) | 2012-02-28 |
| JP2006524342A (ja) | 2006-10-26 |
| EP1618379B1 (en) | 2012-04-04 |
| US20070178536A1 (en) | 2007-08-02 |
| AU2004232007A1 (en) | 2004-11-04 |
| EP1618379A4 (en) | 2008-05-07 |
| WO2004093647A2 (en) | 2004-11-04 |
| US20090299948A1 (en) | 2009-12-03 |
| WO2004093647A3 (en) | 2005-03-10 |
| AU2004232007B2 (en) | 2009-10-22 |
| ATE552501T1 (de) | 2012-04-15 |
| US7588905B2 (en) | 2009-09-15 |
| CA2522261A1 (en) | 2004-11-04 |
| EP1618379A2 (en) | 2006-01-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US8126654B2 (en) | Identification and monitoring of systemic lupus erythematosus | |
| JP4906898B2 (ja) | 全身性紅斑性狼瘡および強皮症の診断およびモニタリング方法 | |
| US11761965B2 (en) | Methods for diagnosing systemic lupus erythematosus | |
| US20110275060A1 (en) | Diagnosing and monitoring inflammatory diseases by measuring complement components on white blood cells | |
| AU2002323691A1 (en) | Diagnosis and monitoring of systemic lupus erythematosus and of scleroderma | |
| US6140065A (en) | Methods for diagnosing benign prostatic diseases and prostatic adenocarcinoma using an algorithm | |
| Waldherr et al. | Basophil activation in insect venom allergy: comparison of an established test using liquid reagents with a test using 5-color tubes with dried antibody reagents | |
| Thomas et al. | Analytical and clinical performance of improved Abbott IMx CA 125 assay: comparison with Abbott CA 125 RIA |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20070330 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20070330 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20091207 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20100105 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100402 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20100616 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20100707 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 4550051 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130716 Year of fee payment: 3 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| EXPY | Cancellation because of completion of term |