JP4545196B2 - 有糸分裂キネシン阻害剤 - Google Patents

有糸分裂キネシン阻害剤 Download PDF

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Publication number
JP4545196B2
JP4545196B2 JP2007552192A JP2007552192A JP4545196B2 JP 4545196 B2 JP4545196 B2 JP 4545196B2 JP 2007552192 A JP2007552192 A JP 2007552192A JP 2007552192 A JP2007552192 A JP 2007552192A JP 4545196 B2 JP4545196 B2 JP 4545196B2
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JP
Japan
Prior art keywords
alkyl
compounds
aryl
cycloalkyl
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2007552192A
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English (en)
Japanese (ja)
Other versions
JP2008527038A5 (enExample
JP2008527038A (ja
Inventor
コールマン，ポール・ジエイ
ハートマン，ジヨージ・デイー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
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Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JP2008527038A publication Critical patent/JP2008527038A/ja
Publication of JP2008527038A5 publication Critical patent/JP2008527038A5/ja
Application granted granted Critical
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Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2007552192A 2005-01-19 2006-01-13 有糸分裂キネシン阻害剤 Expired - Fee Related JP4545196B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64493305P 2005-01-19 2005-01-19
PCT/US2006/001364 WO2006078574A2 (en) 2005-01-19 2006-01-13 Mitotic kinesin inhibitors

Publications (3)

Publication Number Publication Date
JP2008527038A JP2008527038A (ja) 2008-07-24
JP2008527038A5 JP2008527038A5 (enExample) 2009-03-05
JP4545196B2 true JP4545196B2 (ja) 2010-09-15

Family

ID=36692758

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007552192A Expired - Fee Related JP4545196B2 (ja) 2005-01-19 2006-01-13 有糸分裂キネシン阻害剤

Country Status (7)

Country Link
US (1) US20080102068A1 (enExample)
EP (1) EP1856128A4 (enExample)
JP (1) JP4545196B2 (enExample)
CN (1) CN101107253A (enExample)
AU (1) AU2006206738A1 (enExample)
CA (1) CA2595127A1 (enExample)
WO (1) WO2006078574A2 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GT200600371A (es) * 2005-08-17 2007-03-21 Formas de dosis sólidas de valsartan y amlodipina y método para hacer las mismas
WO2009001214A2 (en) * 2007-06-28 2008-12-31 Pfizer Products Inc. Thieno[2,3-d]pyrimidin-4(3h)-one, isoxazolo[5,4-d]pyrimidin-4(5h)-one and isothiazolo[5,4-d]pyrimidin-4(5h)-one derivatives as calcium receptor antagonists
WO2009062199A1 (en) * 2007-11-09 2009-05-14 Fox Chase Cancer Center EGFR/NEDD9/TGF-β LNTERACTOME AND METHODS OF USE THEREOF FOR THE IDENTIFICATION OF AGENTS HAVING EFFICACY IN THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS
US20130331294A1 (en) 2007-11-09 2013-12-12 Fox Chase Cancer Center Egfr/nedd9/tgf-beta interactome and methods of use thereof for the identification of agents having efficacy in the treatment of hyperproliferative disorders
MX353500B (es) 2010-02-17 2018-01-16 Takeda Pharmaceuticals Co Compuesto heterociclico.
JP2013525290A (ja) * 2010-04-15 2013-06-20 ノバルティス アーゲー Ｋｓｐ阻害剤としてのオキサゾールおよびチアゾール化合物
MX2012011910A (es) * 2010-04-15 2012-11-29 Novartis Ag Compuestos de triazol como inhibidores de ksp.
US12084462B2 (en) 2016-09-14 2024-09-10 Janssen Pharmaceutica Nv Spiro bicyclic inhibitors of menin-MLL interaction
AU2017326487B2 (en) 2016-09-14 2021-08-05 Janssen Pharmaceutica Nv Spiro bicyclic inhibitors of menin-MLL interaction
US10611778B2 (en) * 2016-09-14 2020-04-07 Janssen Pharmaceutica Nv Fused bicyclic inhibitors of menin-MLL interaction
MX391405B (es) 2016-12-15 2025-03-21 Janssen Pharmaceutica Nv Inhibidores de azepano de la interacción menina-mll.
US11396517B1 (en) 2017-12-20 2022-07-26 Janssen Pharmaceutica Nv Exo-aza spiro inhibitors of menin-MLL interaction
MX2022007278A (es) * 2019-12-18 2022-09-19 Univ Montreal Moduladores del adaptador kbtbd4 de cullin 3 como compuestos anti-cáncer.
AU2020404305A1 (en) 2019-12-19 2022-08-04 Janssen Pharmaceutica Nv Substituted straight chain spiro derivatives
AU2024265078A1 (en) 2023-05-04 2025-12-11 Revolution Medicines, Inc. Combination therapy for a ras related disease or disorder
WO2025034702A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Rmc-6291 for use in the treatment of ras protein-related disease or disorder
WO2025080946A2 (en) 2023-10-12 2025-04-17 Revolution Medicines, Inc. Ras inhibitors
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors
WO2025255438A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2388646C (en) * 1999-10-27 2009-01-27 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
US7244723B2 (en) * 2001-12-06 2007-07-17 Merck & Co., Inc. Substituted furopyrimidinones as a mitotic kinesin inhibitors
AU2002351183B2 (en) * 2001-12-06 2008-05-08 Merck Sharp & Dohme Corp. Mitotic kinesin inhibitors
WO2003050064A2 (en) * 2001-12-06 2003-06-19 Merck & Co., Inc. Mitotic kinesin inhibitors
WO2003049678A2 (en) * 2001-12-06 2003-06-19 Merck & Co., Inc. Mitotic kinesin inhibitors
EP1551962A4 (en) * 2002-07-08 2007-08-01 Merck & Co Inc MITOTIC KINESIN BINDING CENTER
JP2006515886A (ja) * 2003-01-17 2006-06-08 サイトキネティクス・インコーポレーテッド 化合物、組成物、および方法
WO2004078758A1 (en) * 2003-03-07 2004-09-16 Astrazeneca Ab Novel fused heterocycles and uses thereof

Also Published As

Publication number Publication date
WO2006078574A3 (en) 2007-03-22
EP1856128A4 (en) 2009-12-23
CN101107253A (zh) 2008-01-16
AU2006206738A1 (en) 2006-07-27
CA2595127A1 (en) 2006-07-27
JP2008527038A (ja) 2008-07-24
EP1856128A2 (en) 2007-11-21
US20080102068A1 (en) 2008-05-01
WO2006078574A2 (en) 2006-07-27

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