JP4503849B2 - Ｐｇｅシンターゼおよびその活性をモジュレートする方法及び手段 - Google Patents

Ｐｇｅシンターゼおよびその活性をモジュレートする方法及び手段 Download PDF

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JP4503849B2
JP4503849B2 JP2000581189A JP2000581189A JP4503849B2 JP 4503849 B2 JP4503849 B2 JP 4503849B2 JP 2000581189 A JP2000581189 A JP 2000581189A JP 2000581189 A JP2000581189 A JP 2000581189A JP 4503849 B2 JP4503849 B2 JP 4503849B2
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pge
polypeptide
pge synthase
amino acid
seq
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JP2002539762A (ja
JP2002539762A5 (https=
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ヤコブソン，ペル−ヨハン
サミュエルソン，ベングト
モルゲンシュテルン，ラルフ
マンチーニ，ジョゼフ
フォード−ハッチンソン，アンソニー
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カロリンスカ インスティチュテート イノベーションズ アクティエボラーグ
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553—Metal or metal coated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
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  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
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  • Rheumatology (AREA)
  • Food Science & Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
JP2000581189A 1998-11-09 1999-11-02 Ｐｇｅシンターゼおよびその活性をモジュレートする方法及び手段 Expired - Lifetime JP4503849B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10768798P 1998-11-09 1998-11-09
US60/107,687 1998-11-09
PCT/EP1999/008363 WO2000028022A1 (en) 1998-11-09 1999-11-02 Pge synthase and methods and means for modulating its activity

Related Child Applications (1)

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JP2010011053A Division JP2010115205A (ja) 1998-11-09 2010-01-21 Ｐｇｅシンターゼおよびその活性をモジュレートする方法及び手段

Publications (3)

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JP2002539762A JP2002539762A (ja) 2002-11-26
JP2002539762A5 JP2002539762A5 (https=) 2006-12-14
JP4503849B2 true JP4503849B2 (ja) 2010-07-14

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JP2000581189A Expired - Lifetime JP4503849B2 (ja) 1998-11-09 1999-11-02 Ｐｇｅシンターゼおよびその活性をモジュレートする方法及び手段
JP2010011053A Pending JP2010115205A (ja) 1998-11-09 2010-01-21 Ｐｇｅシンターゼおよびその活性をモジュレートする方法及び手段

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JP2010011053A Pending JP2010115205A (ja) 1998-11-09 2010-01-21 Ｐｇｅシンターゼおよびその活性をモジュレートする方法及び手段

Country Status (9)

Country Link
US (4) US6395502B1 (https=)
EP (1) EP1129188B1 (https=)
JP (2) JP4503849B2 (https=)
AT (1) ATE305040T1 (https=)
AU (1) AU770307B2 (https=)
CA (1) CA2349529C (https=)
DE (1) DE69927400T2 (https=)
ES (1) ES2249042T3 (https=)
WO (1) WO2000028022A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000028022A1 (en) * 1998-11-09 2000-05-18 Karolinska Innovations Ab Pge synthase and methods and means for modulating its activity
US7169580B1 (en) 2000-02-03 2007-01-30 Chugai Seiyaku Kabushiki Kaisha Protein having PGE2 synthase activity and use thereof
AU2002323358A1 (en) * 2001-08-24 2003-03-10 Karoliska Innovations Ab Methods for preparing purified prostaglandin e synthase
JP2005510220A (ja) * 2001-11-30 2005-04-21 ファイザー・プロダクツ・インク プロスタグランジンｅ合成酵素２遺伝子の破壊
JP2006500066A (ja) * 2002-09-25 2006-01-05 ファルマシア・コーポレーション ミクロソームのプロスタグランジンｅ２シンターゼ発現のアンチセンス調節
WO2004067766A1 (en) * 2003-01-27 2004-08-12 Pfizer Products Inc. Novel methods involving the determination of activity of enzymes that use or produce prostaglandin endoperoxide h2
WO2005024059A2 (en) * 2003-09-09 2005-03-17 Karolinska Innovations Ab Methods for identifying compounds for inhibiting fever
US7638331B2 (en) 2004-01-02 2009-12-29 The Administration of the Tulane Rducation Fund Directed apoptosis in COX-2 overexpressing cancer cells through expression targeted gene delivery
US20090088400A1 (en) * 2007-09-11 2009-04-02 Puymirat Jack Prostaglandin e2 modulation and uses thereof
CN117323320B (zh) * 2023-11-20 2025-10-31 复旦大学附属中山医院 长链脂肪酸12-hht在睡眠呼吸暂停合并高血压中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US914356A (en) * 1901-11-30 1909-03-02 Harry Ward Leonard Electric-circuit controller.
AU750187B2 (en) * 1997-09-17 2002-07-11 Johns Hopkins University, The P53-induced apoptosis
WO2000028022A1 (en) * 1998-11-09 2000-05-18 Karolinska Innovations Ab Pge synthase and methods and means for modulating its activity

Also Published As

Publication number Publication date
US20050118696A1 (en) 2005-06-02
US20080153107A1 (en) 2008-06-26
JP2002539762A (ja) 2002-11-26
EP1129188A1 (en) 2001-09-05
CA2349529C (en) 2009-10-27
US20030064493A1 (en) 2003-04-03
AU770307B2 (en) 2004-02-19
US6395502B1 (en) 2002-05-28
EP1129188B1 (en) 2005-09-21
ATE305040T1 (de) 2005-10-15
JP2010115205A (ja) 2010-05-27
CA2349529A1 (en) 2000-05-18
WO2000028022A1 (en) 2000-05-18
US7645601B2 (en) 2010-01-12
DE69927400D1 (de) 2006-02-02
ES2249042T3 (es) 2006-03-16
US7192733B2 (en) 2007-03-20
US7067296B2 (en) 2006-06-27
DE69927400T2 (de) 2006-06-29
AU1504100A (en) 2000-05-29

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