JP4478724B2 - Optical measuring device - Google Patents

Description

  The present invention relates to an optical measurement method and apparatus, and more particularly to an optical measurement apparatus suitable for use in optically measuring the inside of a living body and imaging the inside of the living body based on an information signal obtained thereby.

A technique for measuring the inside of a living body simply and without causing harm to the living body is desired in the field of clinical medicine. In response to this demand, measurement using light is very effective. The first reason is that the oxygen metabolism function in the living body corresponds to the concentration of a specific pigment (hemoglobin, cytochrome a3, myoglobin, etc.) in the living body, that is, the concentration of the light absorber. This is because it can be obtained from the amount of absorption in the near infrared region. The second reason is that light is easy to handle with an optical fiber. The third reason is that optical measurement does not cause harm to the living body when used within the range of safety standards (ANSIZ 136-1973, JISC6802 standard: ² mW / mm ² ).

Utilizing the advantages of living body measurement using light, the living body is irradiated with light having a wavelength from visible to near infrared, and the inside of the living body is reflected from the reflected light at a position about 10-50 mm away from the irradiation position. Apparatuses for measuring are described in, for example, Patent Document 1, Patent Document 2, and the like. Further, for example, Patent Document 3 and Patent Document 4 describe an apparatus that measures a CT image of an oxygen metabolism function from light transmitted through a living body having a thickness of about 100 to 200 mm.
Japanese Patent Laid-Open No. 63-277038 Japanese Patent Laid-Open No. 5300887 JP-A-60-72542 Japanese Patent Laid-Open No. 62-231625 JP-A-9-98972 JP-A-9-149903 Japanese Patent Laid-Open No. 9-19408 Yuichi Yamashita et al. “Near-infrared topographic measurement system: Imaging of absorbers localized in a scattering medium”, 1996 , Review of Scientific Instruments, Vol. 67, 730-732 (Rev. Sci. Instrum., 67, 730 (1996)) Piec Double McCormick et al., “Intracerebral penetration of infrared light”, 1992, Journal of Neurosurgery, Vol. 76, pp. 315-318. Neurosurg., 33, 315 (1992)) Atsushi Maki et al. “Spatial and temporal analysis of human moter activity using noninvasive NIR topography”, 1995, Medical Physics, Vol. 22, 1997-2005 (Medical physics, 22, 1997 (1995))

  Examples of clinical applications using biological light measurement that measures the characteristics caused by the living body using light include, for example, measurement of the activation state of brain oxygen metabolism and measurement of local intracerebral hemorrhage when the head is a measurement target. It is done. In addition, in relation to oxygen metabolism in the brain, it is also possible to measure higher brain functions ranging from movement, sense, and even thought. In such measurement, the effect is greatly increased by measuring and displaying an image rather than a non-image. For example, it is desirable to measure and display as an image in the detection of a local change site of oxygen metabolism.

  In order to acquire an image, a multi-channel optical measurement device is required, and the system is described in Patent Document 5. However, when performing multi-channel measurement, it is possible to quickly find defects in each channel. Is practically important.

  An object of the present invention is to provide an optical measurement device suitable for optically measuring a subject without causing problems due to multiple channels and easily processing and displaying an image of a predetermined item based on information obtained by the measurement. It is to provide.

  According to one aspect of the present invention, a first light irradiating means for irradiating a subject with light, a first light receiving means paired with the first light irradiating means, and a second light irradiating means, , A second light receiving means paired with the second light irradiating means, and a display unit for displaying a metabolite concentration inside the subject, wherein the display unit includes the first light irradiating means and When the substantially middle point of the first light receiving means is the first measurement point, and the substantially middle point of the second light emitting means and the second light receiving means is the second measurement point, the first, The second light irradiating means, the first and second light receiving means, and the arrangement of the first and second measurement points on the subject are displayed on the first window, and displayed on the first window. A graph of changes in metabolite concentration of the subject over time at the first and second measurement points in correspondence with the arrangement of the first and second measurement points. Characterized by measuring the metabolite concentration inside the subject and displaying the second window.

  According to another aspect of the present invention, a plurality of light irradiating means for irradiating a subject with light, a plurality of light receiving means for receiving light emitted from the light irradiating means and propagating through the subject, A display unit for displaying a metabolite concentration inside the subject, wherein the plurality of light irradiation means and the plurality of light receiving means are alternately arranged in a grid pattern, and the plurality of light irradiation means includes a first light An irradiation unit; a first light receiving unit paired with the first light irradiation unit; a second light irradiation unit; and a second light receiving unit paired with the second light irradiation unit. The display unit uses a substantially middle point between the first light irradiating unit and the first light receiving unit as a first measurement point, and a substantially middle point between the second light irradiating unit and the second light receiving unit. Is the second measuring point, the first and second light irradiating means, the first and second light receiving means, and the first and second measuring points. An arrangement of points on the subject is displayed in a first window, and the first and second measurement points are displayed in correspondence with the arrangement of the first and second measurement points displayed in the first window. A metabolite concentration inside the subject is measured, wherein a graph of a change with time of the metabolite concentration of the subject at the measurement point is displayed in a second window.

  According to yet another aspect of the present invention, a first light irradiating means for irradiating a subject with light, a first light receiving means paired with the first light irradiating means, and a second light irradiating means. Means, a second light receiving means paired with the second light irradiating means, and a display unit, wherein the display unit is substantially between the first light irradiating means and the first light receiving means. When the point is the first measurement point, and the substantially middle point between the second light irradiation means and the second light receiving means is the second measurement point, the first and second light irradiation means, 1, a second light receiving means, an arrangement of the first and second measurement points on the subject are displayed, the first and second light irradiation means, the first and second light receiving means, A selection means for selecting whether or not to display the spatial distribution of the concentration of metabolite inside the subject superimposed on the first and second measurement points. Characterized by measuring the metabolite concentration inside the subject.

  According to another aspect of the present invention, a plurality of light irradiating means for irradiating a subject with light, a plurality of light receiving means for receiving light emitted from the light irradiating means and propagating through the subject, and A display unit for displaying a metabolite concentration inside the subject, wherein the plurality of light irradiation means and the plurality of light reception means are alternately arranged in a lattice pattern, and are substantially at a midpoint between the light irradiation means and the light reception means. The measurement points are arranged in a grid, and the display unit displays a graph of the change in metabolite concentration of the subject over time at the measurement points in correspondence with the arrangement of the measurement points. And measuring the concentration of a metabolite in the subject.

  According to the present invention, there is provided an optical measurement device suitable for optically measuring a subject and easily processing and displaying an image of a predetermined item based on information obtained by the measurement.

  FIG. 1 shows a configuration of a main part of an embodiment of an optical measuring device to which the present invention is applied. In this example, an embodiment in which the inside of the cerebrum is imaged by irradiating light on the subject, for example, the skin of the head, and detecting the light reflected in the subject and passed through the subject, This is shown when the number of measurement channels, that is, the number of measurement positions is 12, and the number of signals to be measured (the number of analog / digital conversion channels) is 24. Of course, the present invention is not limited to the head as a measurement target, and can be implemented in other parts, and other than a living body.

The light source unit 1 is composed of four optical modules 2. Each optical module is composed of two semiconductor lasers that emit light of two wavelengths, for example, 780 nm and 830 nm, in the visible to infrared wavelength region. These two wavelength values are not limited to 780 nm and 830 nm, and the number of wavelengths is not limited to two wavelengths. For the light source unit 1, a light emitting diode may be used instead of the semiconductor laser.
Light from all the eight semiconductor lasers included in the light source unit 1 is modulated by the oscillation unit 3 composed of eight oscillators having different oscillation frequencies.

  FIG. 23 shows the configuration of the optical module 2 by taking the optical module 2 (1) as an example. The optical module 2 (1) includes semiconductor lasers 3 (1-a), 3 (1-b), and drive circuits 4 (1-a), 4 (1-b) for these semiconductor lasers. ing. Here, as for the characters in parentheses, numbers indicate the included optical module numbers, and a and b indicate symbols indicating wavelengths of 780 nm and 830 nm, respectively. In these semiconductor laser drive circuits 4 (1-a) and 4 (1-b), a DC bias current is applied to the semiconductor lasers 3 (1-a) and 3 (1-b), and the oscillator 3 By applying signals of different frequencies f (1-a) and f (1-b), the light emitted from the semiconductor lasers 3 (1-a) and 3 (1-b) is modulated. As this modulation, the present embodiment shows the case of analog modulation using a sine wave, but of course, digital modulation using rectangular waves of different time intervals, that is, digital modulation of flashing light at different time intervals may be used. The optical beam thus modulated is individually introduced into the optical fiber 6 by the condenser lens 5 for each semiconductor laser. The two-wavelength light introduced into each optical fiber is introduced into one optical fiber, for example, the irradiation optical fiber 8-1 by the optical fiber coupler 7 for each optical module. For each optical module, two-wavelength optical beams are introduced into the irradiation optical fibers 8-1 to 8-4, and four different positions on the surface of the subject 9 from the other end of these irradiation optical fibers. Light is irradiated to the irradiation position. The light reflected in the subject and passed through the subject passes through the detection optical fibers 10-1 to 10-5 arranged at the detection positions from five detection positions on the subject surface. Detected by the nodes 11-1 to 11-5. The end faces of these optical fibers are in light contact with the surface of the subject 9, and the optical fibers are attached to the subject 9 by a probe described in Patent Document 6, for example.

  FIG. 24 shows an example of the geometric arrangement of the irradiation positions 1 to 4 and the detection positions 1 to 5 on the surface of the subject 9. In this embodiment, the irradiation and detection positions are alternately arranged on a square lattice. Assuming that the midpoint between adjacent irradiation and detection positions is a measurement position, in this case, there are 12 combinations of adjacent irradiation and detection positions, so the number of measurement positions, that is, the number of measurement channels, is 12. The arrangement of the light irradiation and the detection position is described in Patent Document 6 and Non-Patent Document 1, for example. For example, Non-Patent Document 2 reports that when the adjacent irradiation and detection position interval is set to 3 cm, light detected from each detection position passes through the skin and skull and has cerebral information. Yes.

  From the above, if 12 measurement channels are set with this arrangement of irradiation and detection positions, the cerebrum can be measured in a 6 cm × 6 cm region as a whole. In this embodiment, the number of measurement channels is 12 for simplicity, but the number of measurement channels can be further increased by further increasing the number of light irradiation positions and light detection positions arranged in a grid pattern. It is also possible to easily enlarge the measurement area.

  In FIG. 1, the light detected by each of the detection optical fibers 10-1 to 10-5 is detected independently for each detection position, that is, for each detection optical fiber corresponding to each detection position. For example, it is detected by the photodiodes 11-1 to 11-5. This photodiode is preferably an avalanche photodiode capable of realizing highly sensitive optical measurement. A photomultiplier tube may be used as the photodetector. After the optical signal is converted into an electrical signal by these photodiodes, the modulation signal is selectively detected by, for example, a lock-in amplifier module 12 composed of a plurality of lock-in amplifiers, and modulated according to the irradiation position and wavelength. Selectively detect signals. In this embodiment, a lock-in amplifier as a modulation signal detection circuit corresponding to the case of analog modulation is shown, but when digital modulation is used, a digital filter or a digital signal processor is used for detection of the modulation signal.

  FIG. 25 shows the configuration of the lock-in amplifier module 12 of FIG. First, the modulation signal separation of the detection signal detected by the photodiode 11-1 at the detection position 1 in FIG. 24 will be described. From the “detection position 1”, it is possible to detect the light irradiated to the adjacent “light irradiation position 1”, “light irradiation position 2”, “light irradiation position 3”, and “light irradiation position 4”. “Measurement position 4”, “Measurement position 6”, “Measurement position 7”, and “Measurement position 9” in FIG. 24 are measurement target positions. Here, the light detected by the photodiode 11-1 from the “detection position 1” is irradiated to each of the “irradiation position 1”, “irradiation position 2”, “irradiation position 3”, and “irradiation position 4”. The modulation frequencies corresponding to the wavelengths of light are f (1-a), f (1-b), f (2-a), f (2-b), f (3-a), f (3-b ), F (4-a) and f (4-b) are included. An optical signal including these eight signal components is introduced into eight lock-in amplifiers 13-1 to 13-8 via eight amplifiers 14-1 to 14-8. The eight lock-in amplifiers 13-1 to 13-8 include f (1-a), f (1-b), f (2-a), f (2-b), and f (3-a, respectively. ), F (3-b), f (4-a) and f (4-b) modulation frequency signals are given as reference signals. Therefore, the optical signal components of 780 nm and 830 nm irradiated to “irradiation position 1” are locked in by the lock-in amplifiers 13-1 and 13-2, and the optical signal components of 780 nm and 830 nm irradiated to “irradiation position 2” are locked in. The optical signal components of 780 nm and 830 nm irradiated to the “irradiation position 3” by the amplifiers 13-3 and 13-4 are 780 nm irradiated to the “irradiation position 4” by the lock-in amplifiers 13-5 and 13-6. And 830 nm optical signal components are selectively separated and separately locked in by lock-in amplifiers 13-7 and 13-8.

  Similarly, the desired light is detected for the detection signals detected by the photodiodes 11-2 to 11-5 from the “detection position 2”, “detection position 3”, “detection position 4”, and “detection position 5”, respectively. The signal components are selectively separated and lock-in detection is performed. That is, the optical signal detected by the photodiode 11-2 from the “detection position 2” is transferred to the four lock-in amplifiers 13-9 to 13-12 via the four amplifiers 14-9 to 14-12. The optical signal components of 780 nm and 830 nm irradiated to “irradiation position 1” and the optical signal components of 780 nm and 830 nm irradiated to “irradiation position 2” are selectively separated and lock-in detected. The optical signal detected by the photodiode 11-3 from the “detection position 3” is introduced into the four lock-in amplifiers 13-13 to 13-16 via the four amplifiers 14-13 to 4-16. 780 nm and 830 nm optical signal components irradiated to “irradiation position 1” and 780 nm and 830 nm optical signals irradiated to “irradiation position 3” are selectively locked in, respectively. The optical signal detected by the photodiode 11-4 from the “detection position 4” is introduced into the four lock-in amplifiers 13-14 to 13-20 via the four amplifiers 14-17 to 4-20. Then, the 780 nm and 830 nm optical signal components irradiated to “irradiation position 3” and the 780 nm and 830 nm optical signal components irradiated to “irradiation position 4” are selectively lock-in detected, respectively, and “detection position 5” The optical signal detected by the photodiode 11-5 is introduced into the four lock-in amplifiers 13-21 to 13-24 through the four amplifiers 14-21 to 4-24, and the "irradiation position 2" 780nm and 830nm optical signal components irradiated to "irradiation position 4" and 780nm and 830nm light components irradiated to "irradiation position 4" are selectively lock-in detected.

  As can be seen from FIG. 24, the measurement target positions when the detection positions are “detection position 2”, “detection position 3”, “detection position 4”, and “detection position 5” are “measurement position 1” and “ They are “measurement position 3”, “measurement position 2” and “measurement position 5”, “measurement position 10” and “measurement position 12”, and “measurement position 8” and “measurement position 11”.

As described above, when the number of wavelengths is 2 and the number of measurement positions is 12, the number of signals to be measured is 24. Therefore, the lock-in amplifier module 12 has a total of 24 lock-in amplifiers 13-1 to 13-1. 13-24 is used. The analog output signals output from these lock-in amplifiers 13-1 to 13-24 (channels 1 to 24) are integrated for a predetermined time by the sample hold circuit of the corresponding channel of the sample hold circuit module 16, respectively. Is done.
After the integration is completed, the switches (multiplexers) 17 are sequentially switched, and the signals accumulated in the respective sample hold circuits are converted into digital signals by, for example, a 12-bit analog / digital converter (A / D converter) 18. The converted signals of all channels are stored in a storage device outside the computer 19. Of course, this storage may be performed in a storage device inside the computer 9. The channel number and the storage device address correspond to 1: 1.

  When the sample hold circuit module 16 is not used, the switch 16 is repeatedly switched at a high speed. At each switching, the analog signal of each channel is converted into a digital signal by the analog / digital converter 18 and stored in the storage device 20, and the digital signal obtained a predetermined number of times for each channel is averaged by the computer 19, Store in the storage device 20. This method can also reduce high-frequency component noise.

  Based on the stored data, the computer 19 calculates changes in oxygenated hemoglobin concentration and deoxygenated hemoglobin concentration associated with brain activity, and further changes in total hemoglobin concentration as a total amount of these hemoglobin concentrations. Calculation is performed by the method described in Document 7 and Non-Patent Document 3 described above, and a topography image or the like is displayed on the display unit 20.

  In FIG. 1, the computer 19 may be a personal computer. An operation unit 22 is connected to the computer 19, and the operation unit includes a keyboard and a mouse for inputting and outputting various information and for adding and deleting data.

  FIG. 26 is a graph showing changes over time of the measurement signal 30 at a certain detection position and the predicted no-load signal 31 obtained from the measurement signal. This graph is displayed on the display unit 21, the horizontal axis represents the measurement time, and the vertical axis represents the relative change in hemoglobin concentration, that is, a specific function of the living body (for example, moving a part of the body such as a finger). Corresponds to hemoglobin concentration changes in specific parts of the brain due to the action of. The predicted no-load signal 31 excludes signals from the measurement signal 30 at the time when the load is applied (load time) Ts and the time after the load is applied until the signal returns to the original state (relaxation time) T2. This is obtained by fitting an arbitrary function (baseline) to the measurement signal 31 at time T3 after application using the least square method. In this embodiment, a second-order linear polynomial is used as the arbitrary function, and T1 = 40 seconds, T2 = 30 seconds, and T3 = 30 seconds.

FIG. 27 is a graph displayed on the display unit 21 showing the time change of the relative change amount of the oxidized and reduced hemoglobin concentration at a certain measurement position, and these are indicated by 32 and 33.
The horizontal axis represents the measurement time, and the vertical axis represents the relative density change amount. Also, the time indicated by diagonal lines is the load application time (right finger movement period). With respect to the relative change amount of FIG. 26, based on the no-load signal 31 and the predicted no-load signal 32, the relative change amount due to load application of the concentration of oxidized and reduced hemoglobin (HbO 2, Hb) is obtained by a predetermined calculation process.

FIG. 28 and FIG. 29 are contour images displayed on the display unit 21, which are created from changes in the relative change amount of oxyhemoglobin concentration at each measurement point with the exercise of the left and right fingers of the subject as loads. (Topography image) is shown. For the topography image, the processing unit 19 calculates a time integration value (or a time average value) of the relative change amount signal 32 during the load application time (the hatched period in FIG. 27), and the value between each measurement position is the X-axis direction. And the linear interpolation in the Y-axis direction.
The topographic image may be a black and white grayscale image or a color identification display image in addition to the contour lines as shown in FIGS. From the comparison of the images of FIGS. 28 and 29, it can be clearly seen that the concentration of oxyhemoglobin increases at a specific position during right hand movement.

  By displaying such spatial distribution information as an image, the measurement result can be recognized quickly and easily. The images shown in FIG. 28 and FIG. 29 were created with the time integral value of the concentration relative change amount during the load application time, but similarly, depending on the relative change amount of oxyhemoglobin concentration at each measurement position for the same measurement time. It is also possible to create a topographic image. If the created topographic images are displayed or displayed as a moving image in the order of the measurement time, it is possible to capture temporal changes in the amount of relative change in oxyhemoglobin concentration.

  Furthermore, the self-correlation function of the time change of the relative change amount of the oxyhemoglobin concentration at any one measurement position and the time change of the relative change amount of the oxyhemoglobin concentration at the other measurement position is calculated, and the correlation function at each measurement position is calculated. A topographic image can also be created. Since the correlation function at each measurement position is a function defined by the time lag τ, if a topography image is created from the value of the correlation function at the same time lag τ and displayed according to the order of τ or displayed as a moving image, the hemodynamics You can visualize how changes are propagated. Here, the relative change amount of oxyhemoglobin concentration is described as a representative, but the relative change of total hemoglobin concentration calculated by the sum of the relative change amount of reduced hemoglobin concentration or the relative change amount of oxidized and reduced hemoglobin concentration. A topographic image can be created in the same way for the amount.

  FIG. 30 shows a display example in which the topography image 34 created by the method described above is superimposed on the brain surface image 35 of the subject. Since the topographic image 34 is a change in the blood dynamics of the brain that has changed in relation to the function of the living body, it is desirable to display the topographic image 34 so as to overlap the brain surface image. The brain surface image 35 is measured and displayed by 3D MRI or 3D X-ray CT. The topography image 34 is obtained by performing a statistical process based on a signal obtained from the detection position, by converting the coordinates of the measurement positions so that the coordinates of the measurement positions are located on the brain surface, and obtaining values between the measurement positions after the coordinate conversion. For example, a topography image is created by performing a storage process called a spline process. When the created topography image 34 and the brain surface image 35 are superimposed and displayed, the color of the superimposed topography image 34 is made translucent so that the underlying brain surface image can be seen through.

  FIG. 92 shows a measurement flow as an example based on the present invention when the subject is measured using the optical measurement device shown in FIG. Details of the measurement will be described later with reference to FIGS. 2 to 22. As can be seen from the measurement flow of FIG. 92, when the measurement is roughly started, the program of the optical measurement device is started in step S921. The screen changes as in steps 922 to 926, and the measurement ends in step 927.

  In FIG. 92, the screen displayed in step 922 is the screen shown in FIG. 4 described later, and the measurement mode is selected on this screen. The screen displayed in step 923 is a screen shown in FIG. 6 to be described later. Here, the apparatus initial setting and the measurement position display are performed. The measurement position is displayed so that the correspondence with the measurement signal can be understood. The screen displayed in step S924 is a screen shown in FIG. 10 to be described later. Here, measurement can be started and mark input can be performed. The screen displayed in step 925 is a screen shown in FIG. 14 to be described later. Here, the measurement signal is displayed. In step S926, the measured signal can be registered as a file on the screen displayed in FIG. 8 described later. The screens in steps S923 to 925 can be displayed in one screen as shown in FIG.

  FIG. 2 shows an example of a flow according to the present invention, in which a subject is measured using the optical measuring device shown in FIG. The operation can be sequentially advanced while the operator sees the screen displayed on the screen display surface of the display unit 21 shown in FIGS.

  When the operating system of the apparatus is started up, first, an initial screen for main menu selection shown in FIG. 3 is displayed (S1). In FIG. 3, when the button 301 is selected, the process proceeds to measurement processing, when the button 302 is selected, the process proceeds to data analysis, and when the button 303 is selected, the program is terminated.

If the button 301 is selected, the initial screen shown in FIG. 3 is deleted and the process proceeds to measurement processing. First, the condition input screen shown in FIG. 4 is displayed at the center of the display surface of the display unit 21 ( S2). In FIG. 4, the meaning and function of each part are as follows.
401: A bar for inputting a title (name of examination to be performed).
402: Date and time are displayed, and the date and time when the screen is displayed are displayed by default (numbers and characters displayed automatically).
403: A part for inputting the type of stimulus (for example, finger movement, writing, speech, drug administration, etc.).
Press the list display button (inverted triangle button) and select the registered type from the list box. The selected type is displayed with the background color changed. Data can be added, deleted and replaced.
404: The type item selected by the stimulus input unit can be deleted.
405: A part for selecting a measurement mode. The measurement mode is determined by the number of measurement channels and the number of surfaces to be measured. For example, when the number of measurement channels is 12 and the number of surfaces to be measured is 2, the measurement mode 1 is set.
406: A free memo writing portion.
407: A part for inputting a subject name.
408: A part for inputting the age of the subject.
409: A part for inputting the gender of the subject.
410: A part for inputting the type of the subject, that is, a patient or a healthy person.
411: A setting end button.
412: A button for returning to the initial screen.

  When the above conditions are input and set, when the button 412 is pressed, the condition input screen shown in FIG. 4 is deleted and the flow returns to the initial screen display. However, when the button 411 is pressed, the condition input screen shown in FIG. The condition input screen to be displayed is deleted, and the display screen for gain adjustment shown in FIG. 5 is displayed at the center of the display surface (S3). This indicates that the measurement system is performing automatic gain adjustment. When the adjustment is completed, the gain adjustment screen shown in FIG. 5 is deleted, and the measurement position display screen shown in FIG. 6 is displayed in the center of the display surface ( S4). This screen is basically always displayed at a predetermined position on the display surface of the display unit 21 thereafter. By constantly displaying this measurement position display screen, it is possible to easily and quickly grasp the correspondence between a large number of measurement signals and actual measurement positions. Here, normally, the irradiation optical fibers 8-1 to 8-4 and the detection optical fibers 10-1 to 10-5 in FIG. 1 are fixed to a helmet worn by the subject. Therefore, if the measurement channel number is clearly indicated on the helmet and the positional relationship with the number 602 in FIG. 6 is clarified in advance, the operator is further recognized.

  In FIG. 6, reference numeral 601 denotes a portion for displaying the selected measurement mode, and the displayed measurement position display screen corresponds to the selected measurement mode. Reference numeral 602 denotes a portion that displays the number of measurement channels on the measurement surface. Reference numeral 603 denotes a set position of the irradiation and detection optical fibers, that is, a light irradiation position and a detection position. Reference numeral 604 denotes a measurement channel number. When the automatic gain and irradiation light amount adjustment are successful, the measurement channel is displayed in green.

  If there is even one measurement channel that is inappropriate to be measured because the gain and irradiation light amount adjustment is not successful, the measurement channel is displayed in red. In this case, the abnormality display screen shown in FIG. 7 is also displayed in the vicinity of the measurement position display screen shown in FIG. 6 (S5). If the gain and irradiation light amount adjustment is not successful, it means that there may be a problem in the measurement position on the right, left, or top of the red display. In the case of red display, it is considered that the setting of the optical fiber is bad, so it is necessary to reset the setting of the optical fiber. Therefore, after resetting the optical fiber, 701 in FIG. 7 is used when returning to the screen of FIG. 3 or 4 to stop the measurement. When the button 702 in FIG. 7 is pressed, the abnormality display screen shown in FIG. 7 is deleted, the display screen for gain adjustment shown in FIG. 5 is displayed, and automatic gain and irradiation light amount adjustment are performed again. If there is an abnormality again after adjusting the gain and irradiation light quantity, the display screen during gain adjustment shown in FIG. 5 is deleted, and the abnormal measurement channel on the measurement position display screen shown in FIG. Is displayed near the measurement position display screen shown in FIG. If no abnormality occurs, the gain adjustment display screen shown in FIG. 5 is deleted, all measurement channels in the measurement position display screen shown in FIG. 6 are changed to green display, and the file creation screen shown in FIG. 8 is displayed. Is displayed.

In FIG. 7, reference numeral 703 denotes a button to be pressed when ignoring the abnormality. When this button is pressed, the abnormal measurement channel in the measurement position display screen shown in FIG. 6 is ignored (red display) and shown in FIG. A file creation screen is displayed (S6). Regardless of the presence or absence of abnormality, the file creation screen shown in FIG. 8 is displayed in the center of the display surface, and the measurement position display screen shown in FIG. 6 is displayed on the display screen along with the display of the file creation screen shown in FIG. The position moves to the lower left of the inside.
With this display method, the operator can always pay attention to the conditions to be input.

In FIG. 8, the meaning and function of each part are as follows.
801: A part for inputting a file name.
802: A part for displaying a list of all files existing in the hierarchy selected by the button 804. For example, here, the data name measured before is displayed.
803: A part for displaying the current path.
804: A part for displaying a directory list (hierarchical list).
805: A button for giving permission to proceed to the measurement process.
806: A button that is pressed to cancel and return to the condition input screen of FIG. When this button is pressed, the file creation screen shown in FIG. 8 and the measurement position display screen shown in FIG. 6 are deleted, and the condition input screen shown in FIG. 4 is displayed.
807: A button used when the directory creation screen shown in FIG. 9 is displayed to create a new directory. When this button is pressed, the directory creation screen is displayed with a slight shift on the file creation screen shown in FIG. At this time, the directory creation screen shown in FIG. 9 cannot be operated.
808: A button for specifying a drive.

When the button 807 is pressed, the directory creation screen shown in FIG. 9 is displayed (S7).
In FIG. 9, 901 is a part for inputting the name of a directory to be created, 902 is a directory creation end button, 903 is a cancel button, and the directory creation screen shown in FIG. Returning to the file creation screen shown in FIG.

In FIG. 8, when the button 805 is pressed, the file creation screen shown in FIG. 8 is deleted, the measurement screen shown in FIG. 10 is displayed on the upper left of the display surface (S8), and the measurement data shown in FIG. One or more time-series display screens are displayed on the right most part of the surface (S11). At this time, a time series graph may be arranged at a position corresponding to the actual measurement position. FIG. 10 is used to control the execution of the measurement. In FIG. 10, the meaning and function of each part are as follows.
1001: When Info is selected with a button for selecting Info, a screen for selecting Condition or Tuneup as a submenu is displayed as shown in FIG. When Condition in the submenu of FIG. 11 is selected, the same condition input screen as that of FIG. 4 is displayed (S9). This is for the purpose of confirming the current situation or inputting additional conditions. When Tuneup in the submenu of FIG. 11 is selected, an input screen for measurement conditions and display conditions shown in FIG. 12 is displayed (S10).
When the cancel button is pressed in S9 or S10, the condition input screen shown in FIG. 4 or the measurement condition and display condition input screen shown in FIG. 12 is deleted, and the screen returns to the measurement screen of FIG.
1002: A button for selecting Option. When Option is selected, a sub-menu screen is displayed as shown in FIG. Here, conditions such as graph display conditions during measurement, data backup interval, and signals output from other measuring devices, which will be described later, are input, but the values set during the previous measurement are automatically reflected. It is not necessary to set every time because of the learning function.
1003: A part for designating and displaying a data acquisition time interval.
1004: A part for displaying the number of times of data acquisition (sampling number).
1005: A part for displaying the elapsed measurement time (time from the start of measurement).
1006: A part for displaying the next measurement state.
Run: Measuring
Completion: Measurement ends normally
Overrun: A / D converter overflow due to measurement overrun
Stop: Other measurement abnormal termination
File error: Measurement file write error
Back up file error: Backup file write error
1007: A button for starting measurement. When this button is pressed, measurement is performed and a measurement data time series signal graph is displayed on each axis in FIG. 14 (S11). The displayed graph represents, for example, the rate of change, but the original signal or Hb concentration may be displayed.
1008: A button for ending data acquisition.
1009: A button for finishing measurement and inspection.
1010: A part for displaying an elapsed time after the mark button 1011 is pressed. This provides the convenience of not having to manage the stimulation time with a stopwatch.
1011: A mark button. This is for putting a mark consisting of a vertical line in the graph of FIG. 14 during measurement. Normally, this mark is input at the end of the stimulus as a reference for data analysis, but it may be input arbitrarily when an event for which time is desired to be recorded occurs during measurement. When a mark input signal is automatically input from an external device, the mark is displayed in FIG. 14 without pressing this button. In addition, a sound may be generated when a mark is input.

In the measurement condition and display condition input screen shown in FIG. 12, measurement conditions corresponding to the selected measurement mode are displayed. The measurement conditions represent correspondences of measurement channels (measurement positions), A / D converter channels, wavelengths, signal amplification factors, and the like. Here, it is also possible to specify a channel to be measured and a channel to be displayed in a graph. Further, it is possible to instruct to input another signal to a vacant channel. The meaning and function of each part in the screen of FIG. 12 are as follows.
1201: There is a table showing measurement conditions and display conditions for each wavelength used in the selected measurement mode, and a table relating to the wavelength to be presented is selected using this tab.
1202: A part for specifying and displaying the necessity of graph display. True means graph display, false means graph non-display. Select in advance for each measurement channel you want to hide the graph (select by clicking in the Visible column and the background color will change or be highlighted), and specify 1212 False button to select The measurement channel changes from True to False.
1203: A part for displaying the gain of the lock-in amplifier.
1204: A part for displaying the dynamic range of the A / D converter. 1203 and 1204 display values determined by automatic gain adjustment.
1205: A part for displaying the wavelength.
1206: A part for displaying the type of signal. Optical means optical measurement. For example, when an electroencephalogram signal is simultaneously measured on an additional channel (addition can be specified in 1208), an EEG and an operator are input. At the time of data analysis, signals other than Optical can be distinguished and processed.
1207: A part for displaying a measurement channel number.
1208: A part for designating and displaying valid (True) / invalid (False) of the channel number of the A / D converter. The designation method is the same as in the case of 1202. When set to False, measurement is not performed on the specified channel.
1209: A character string, a number, or the like is input at the selected position of 1202-1208.
1210: A part for changing the dynamic range of the A / D converter. Effective when 1204 is selected.
1211: A part for changing the gain of the lock-in amplifier. Effective when 1203 is selected.
1212: A part for switching between True and False in columns 1202 and 1208.
1213: A part for selecting a measurement mode to be displayed. Each displays the table to be displayed in multiple tables for each wavelength, and All displays all measurement channels in a single table.
1214: A button for ending the setting.
1215: A button for canceling the setting.

  According to the screen of FIG. 12, the monitor of the measurement conditions (1203 to 1208) and the graph display (1202) conditions are displayed on one screen, and confirmation and setting change can be easily performed. In addition, signals from other measuring devices (devices) can be captured using this screen. Furthermore, the screen of FIG. 12 is the only screen for inputting conditions for the operator to select whether or not to measure the input signal.

In the Option sub-menu screen in the measurement screen of FIG. 10 shown in FIG. 13, the following screens are displayed depending on what is selected. However, in FIG. 13, the display of Trigger Pulse and External Trigger to be selected is omitted.
Graph: Graph display condition input screen of FIG. 14 (FIG. 15)
Backup: File backup condition input screen (Fig. 16)
Other CH: Input setting screen for other measurement device output signals (Fig. 17)
Trigger Pulse: Rectangular wave output signal setting screen (Figure 18)
External Trigger: External input trigger-synchronous measurement condition setting screen (Fig. 20)
Measurement
Parameter: Measurement data acquisition condition setting screen (Fig. 21)
Prescan: Measurement signal confirmation screen (Fig. 22)
Position: Measurement position display screen (Fig. 6) (return to step S6)
The meaning and function of each part of the screens of FIGS. 15 to 18 and 20 to 22 will be described below.

FIG. 15 (graph display condition input screen of FIG. 14) (S12)
1). Enter the X-axis range. There are two types of input methods for inputting the range: input at the magnification performed in 1501 and input at the display time performed in 1503.
1501: A button for selecting display magnification input for the X-axis of the graph.
1502: A portion for inputting the display magnification of the X-axis of the graph as a percentage. For example, when displaying a period of 3600 seconds at 100%, changing to 1000% results in a range of 360 seconds. In this case, when 360 seconds are exceeded, the screen scrolls to the left. Specifically, when 362 seconds of data are acquired, the X-axis range of the graph of FIG. 14 displays signals from 2 seconds to 362 seconds.
1503: A button for selecting display time input for the X-axis of the graph. When this button is selected, 1501 is automatically deselected. The buttons 1501 and 1503 are mutually exclusive.
1504: A part for inputting the display time of the X-axis of the graph.
1505: A portion for displaying the number of data acquired within the display time designated by 1504.
2). Enter the Y-axis range.
1506: A part for inputting the display magnification of the Y-axis of the graph. The idea is the same as in the case of X-axis magnification input.
3). The graph display format of FIG. 14 is selected.
1507: A button for selecting display of all channels (all channels selected and displayed in FIG. 12) in the order of measurement channels. When this button is selected,
The same number of screens in FIG. 14 as the number of wavelengths used in the measurement of each measurement channel (two wavelengths in the embodiment) are displayed without overlapping. At this time, the first screen displays signals in the order of measurement channels of the first wavelength, and the second screen displays signals in the order of measurement channels of the second wavelength. If not set, Together is selected. At this time, the signals may be displayed in the order of the measurement channels as shown in FIG. 14, but may be arranged at a position corresponding to the measurement position.
1508: A button for displaying all channels in one window.
1509: A button for displaying a graph in an individual window for each channel. Furthermore, there are the following two types of display methods.
Title: Graphs are displayed in tiles.
Cascade: Display graphs in an overlapping manner.
1510: A graph of only one designated channel is displayed (the channel displayed in FIG. 12 can be selected).
1511: A part for forcing not to display the graph.
1512: A part for finishing the setting. When the setting is completed, the screen display returns to the screen display of FIG.
1513: A part for canceling. Even in the case of cancellation, the screen display returns to the screen display of FIG.

FIG. 16 (file backup condition input screen) (S13)
This is to set conditions for the function to back up data at any time during measurement in anticipation of a power failure during measurement or the case where the file specified on the file creation screen in Fig. 8 is damaged for some reason. To do.
1601: A part for designating whether or not back-up is necessary.
1602: A part for inputting a backup interval time.
1603: A part for inputting a backup file name with a full path.
1604: A part for referring to a directory and a file. The file creation screen of FIG. 8 is displayed, and the designated file name enters the Backup File Name area 1603. 1605: A button for finishing setting. When the setting is completed, the screen display returns to the screen display of FIG.
1606: A cancel button. Even in the case of cancellation, the screen display returns to the screen display of FIG.

FIG. 17 (input setting screen for other measuring device output signal) (S14)
Using this screen, the vacant A / D converter channel data is acquired from the signals output from other measuring devices. The channel number of the A / D converter at the time of acquisition, the signal type name (EEG etc.), and the dynamic range of the A / D converter are selected.
1701: A part for displaying a channel number of an available A / D converter for input. The lowest number of available A / D converter channels is automatically assigned.
1702: A part for inputting a signal type name.
1703: A part for selecting the dynamic range of the A / D converter of other input.
1704: A button for ending setting. When the setting is completed, the screen display returns to the screen display of FIG.
1705: A cancel button. Even in the case of cancellation, the screen display returns to the screen display of FIG.

FIG. 18 (rectangular wave output signal setting screen) (S15)
A rectangular voltage signal is periodically output from the optical measuring device. By inputting this signal to another measuring device (such as an electroencephalograph), the measurement time can be strictly matched between the devices. The rectangular wave signal is output from a sill alport of a personal computer, for example.

There are three types of rectangular wave signals to be output as shown in FIG. The first type is a rectangular wave signal output only at the start. The second type is a rectangular wave signal that is periodically output until the end of measurement. The third type is a rectangular wave signal output in synchronization with pressing the mark button 1011 in FIG. Conditions for these three types of rectangular wave signals can be set on the screen of FIG.
1801: A part for selecting whether or not to output a rectangular wave.
1802: A part for selecting a terminal for outputting a rectangular wave.
1803: A part for inputting the time width of the first type of rectangular wave (see A in FIG. 19). 1804: A part for inputting the number of repetitions of the first type of rectangular wave (see B in FIG. 19).
1805: A part for inputting the number of repetitions of the second type of rectangular wave (see C in FIG. 19).
1806: A part for inputting the time width of the second type of rectangular wave (see D in FIG. 19). 1807: A part for inputting the time width of the third type of rectangular wave (see E in FIG. 19). 1808: A setting end button. When the setting is completed, the screen display returns to the screen display of FIG.
1809: A cancel button. Even in the case of cancellation, the screen display returns to the screen display of FIG.

FIG. 20 (external input trigger-synchronous measurement condition setting screen) (S16)
This screen is used when measuring in synchronization with an external trigger signal.
By synchronous measurement, time can be completely synchronized with other measuring devices and stimulators.
2001: A part for designating whether external input trigger synchronous measurement is necessary.
2002: A part for inputting the channel number of the A / D converter used for the external input trigger signal.
2003: A part for inputting a measurement time for one trigger signal.
2004: A part for inputting a threshold value of a voltage value recognized as a trigger signal.

2005: A button for ending the setting. When the setting is completed, the screen display returns to the screen display of FIG.
2006: A cancel button. Even in the case of cancellation, the screen display returns to the screen display of FIG.

FIG. 21 (Measurement data acquisition condition setting screen) (S17)
Here, the operation frequency (Burst Rate) of the channel of the A / D converter, the sampling frequency (Coversion Rate) per channel of the A / D converter, the average number of acquisition data (Number of Samples), the acquisition It is possible to set a data addition time (Acquisition Time), a data acquisition time interval (Sampling Period: the same as 1003 in FIG. 10), and a previous measurement time.
2101: A part for displaying and inputting a Burst Rate.
2102: A part for displaying and inputting the conversion rate.
2103: A part for displaying and inputting the number of samples acquired by one sampling.
2104: A part for displaying the data acquisition time.
2105: A part for displaying and inputting a data acquisition time interval.
2106: A part for displaying and inputting the measurement time.
2107: A button for finishing setting. When the setting is completed, the screen display returns to the screen display of FIG.
2108: A cancel button. Even in the case of cancellation, the screen display returns to the screen display of FIG.

FIG. 22 (Measurement signal confirmation screen) (S18)
This screen is used for the operator to perform preliminary measurement before entering the main measurement, if necessary, and for the operator to check the signal state. The value of the signal displayed in the graph represents the voltage value.
2201: A part for displaying a data acquisition interval.
2202: A part for displaying the number of times of data acquisition (sampling number).
2203: A portion for displaying the measurement elapsed time.
2204: A part for displaying a measurement state (see FIG. 10).
2205: A part for designating the magnification in the X direction of the graph (see FIG. 15).
2206: A part for displaying a numerical value for each channel in which the preliminary measurement result is written.
2207: A button for starting output signal confirmation. When this button is pressed, one or a plurality of measurement signals are displayed in the screen shown in FIG. 14 according to the style of the graph set in the screen shown in FIG.
2208: A button for interrupting measurement.
2209: A button for ending preliminary measurement. When this button is pressed, the display screen returns to the screen of FIG.

  FIG. 94 shows an analysis flow as an example based on the present invention when data analysis (calculation processing) after measurement processing is performed using the optical measurement device shown in FIG. Details of the data analysis will be described later with reference to FIGS. 31 to 68. As can be understood from the data analysis flow of FIG. 94, the data measurement program is generally started in step 941 during the data analysis. Then, the screen transitions as shown in steps 942 to 946, and the data analysis ends in step 947.

  In FIG. 94, the screen displayed in step 942 is a screen shown in FIG. 33 to be described later. Here, the data analysis mode is selected. The screen displayed in step 943 is the screen shown in FIG. 34. Here, a registered data file can be read. The screen displayed in step 944 is the screen shown in FIGS. 43, 48, 49, etc., where the data processing method (arithmetic processing method) is set. The screen displayed in step 945 is the screen shown in FIG. 53, where an image is created, and in step 946, it is registered as a file through the displayed image shown in FIG.

  FIG. 31 shows a flow as an example based on the present invention in which data analysis (arithmetic processing) is performed after performing measurement processing using the optical measuring device shown in FIG.

After the measurement process is completed, the screen returns to the main menu selection initial screen shown in FIG. 3, and when the button 302 in the initial screen is pressed, the process proceeds to the data analysis step, and the initial screen shown in FIG. Instead, the process selection screen shown in FIG. 32 is displayed (S20). In FIG. 32, the meaning and function of each part are as follows.
3201: A button for selecting an image creation process.
3202: A button for selecting a created or processed image and graph display mode.
3203: Pressing this button can proceed to the selected process.
3204: End button. When this button is pressed, the screen returns to the initial screen.

In FIG. 32, when the button 3203 is pressed, the analysis mode selection screen 33 shown in FIG. 33 is displayed instead (S21). In the same figure, when the button 3301 is pressed, the operation proceeds to the addition average analysis mode, and when the button 3302 is pressed, the operation proceeds to the non-addition average analysis mode. When the button 3303 is pressed, the processing selection screen returns. When any of the buttons 3301 and 3302 is pressed, the file reading screen shown in FIG. 34 is displayed instead (S22). In FIG. 34, the meaning and function of each part are as follows.
3401: A button for designating a folder (directory).
3402: A button used when moving to a higher hierarchy folder.
3403: A button used when creating a new folder.
3404: A button for designating a list display. When this button is pressed, the contents in the directory can be displayed.
3405: A button used to display more detailed contents than the contents of the directory obtained by pressing the button 3404.
3406: A button used to display folders and files in the directory.
3407: A button used to input a file name. When this button is pressed, the file name of the file displayed by selecting the button 3406 is automatically displayed.
3408: A button for selecting a file type. The type of file selected here is displayed by pressing a button 3406.
3409: A button used to read a selected file and proceed to the next.
3410: A cancel button that is pressed returns to the screen shown in FIG.

  In FIG. 34, when the button 3409 is pressed, the mark edit screen shown in FIG. 35 and the mark edit auxiliary screen shown in FIG. 36 are displayed simultaneously (S23). In this case, the former screen is displayed on the left side and the latter screen is displayed close to each other on the right side. On the mark editing auxiliary screen, the time or sampling count indicated by the mark displayed on the mark editing screen is displayed in the order of the mark. On the mark edit auxiliary screen, when the check mark is deleted and the button 3605 is pressed, the mark on the mark edit screen is deleted, and the value on the mark edit auxiliary screen is also deleted.

  As will be described later, when the time or sampling count to be added is input in the box 3603 and the button 3604 is pressed, a mark is added on the mark edit screen, and a value is also added on the mark edit auxiliary screen. Is done.

  Another way of editing the mark is to use a mouse edit line 3515 (moving in conjunction with the mouse) representing the position of the mouse cursor. In this case, the moved position (time and count number) of the line is displayed as a number in boxes 3504 and 3507 (described later). When a button 3510 is pressed at a desired position, a mark is added on the mark edit screen and a numerical value is added to the mark edit auxiliary screen. When the mouse edit line 3515 comes to an existing mark, a button 3509 (described later) becomes active (the button can be pressed), and when the button 3510 is pressed, the mark is deleted.

  There is yet another way to add a mark. In this case, a count number to be marked is input in a box 3508 (described later), and a button 3509 (described later) is selected. A mark is added by this selection, and the result is reflected on the mark editing screen and the mark editing auxiliary screen.

35 and 36, the meaning and function of each part are as follows.
3501: When this button is pressed, the File menu shown in FIG. 37 is called. When Save As is selected, a file save screen shown in FIG. 40 can be called to save the edited result. At this time, the extension of the original data (data before editing) is changed to BAK, and the original data is also saved. This prevents the loss of original data.

3502: Pressing this button invokes the Edit menu shown in FIG. When Parameter is selected, the graph display adjustment screen for mark editing shown in FIG. 41 is called, and the X axis and Y axis magnifications and the X axis time or count number on the mark editing screen (FIG. 35) are adjusted. can do.

3503: When this button is pressed, the Option menu shown in FIG. 39 is called. In the Option menu, there are choices for Condition and Tuneup Info. When Condition is selected, the measurement condition display input screen shown in FIG. 42 is displayed. When Tuneup Info is selected, the measurement condition and display condition input screen shown in FIG. 12 is displayed (in FIG. 12, the button 1215 is clicked). Press to return to the screen of FIGS. 35 and 36).
3504: A part for displaying the time corresponding to the mouse edit line 3515.
3505: A part for displaying a data value (value on the vertical axis) corresponding to the mouse edit line 3515.
3506: A portion where a check mark is displayed when the position of the mouse edit line 3515 matches the existing mark position.
3507: A portion for displaying the count value at the position indicated by the mouse edit line 3515.
3508: A part for inputting a mark addition position as a count value.
3509: a button used to add a mark at the position of the count value or mark edit line 3515 input in the portion 3508.
3510: A part used for deleting a mark.
3511: A button used to proceed to the next process. When this button is pressed in the case of the addition average analysis mode, the processing time definition screen for addition average analysis shown in FIG. 43 is displayed. In the case of the non-addition average analysis mode, when this button is pressed, The non-addition average analysis processing time definition screen shown in FIG. 48 is displayed.
3512: A button for canceling. When this button is pressed, the screen returns to the file reading screen shown in FIG.
3513: Graph measurement data is shown.
3514: Indicates a mark position.
3515: A mouse editing line (moving in conjunction with the mouse) indicating the position of the mouse cursor is shown.
The position is reflected in the numerical value in the box 3507.
3601: A part for displaying a count value of data at the left (odd number) mark position of two marks in a pair. When deleting, the check mark display is deleted.
3602: A part for displaying a count value of data at a mark position on the right side (even number) of two marks in a pair. When deleting, the check mark display is deleted.
3603: A box for inputting a count value or time of a mark position to be added.
3604: When this button is pressed, a mark is added at the position of the value input in the box 3603.
3605: When this button is pressed, the added or deleted data is reflected in the graph and processing.

  The meaning and function of each part of FIGS. 40 to 43 and FIG. 48 selected and displayed on the mark editing screen shown in FIG. 35 will be described below.

FIG. 40 (file saving screen) (S24)
4001: A part for designating a folder (directory).
4002: A button used when moving to an upper layer folder.
4003: A button used when creating a new folder.
4004: A button used to designate a list display and display the contents in the directory.
4005: A button used to display more detailed contents than the contents of the directory obtained by pressing the button 4004.
4006: A button used to display folders and files in the directory.
4007: A button used to input a file name. When this button is pressed, the file name of the file displayed by selecting the button 4006 is automatically displayed.
4008: A button used to select a file type. The type of file selected here is displayed when a button 4006 is pressed.
4009: A button used to save the selected file and proceed to the next.
4010: A button used when canceling. When this button is pressed, the screen returns to the screen shown in FIG.

FIG. 41 (Mark Edit Graph Display Adjustment Screen) (S25)
4101: A box for selecting the number of an A / D conversion channel to be displayed in a graph.
4102: A box for inputting an X-axis magnification.
4103: A box for inputting the magnification of the Y-axis.
4104: A button for selecting to set the display value of the X axis to the count value.
4105: A button for selecting that the display value (count) of the X-axis is to be thinned out (flyed out).
4106: A button for selecting to set the display value of the X axis to the time.
4107: A button for selecting display of the X-axis display value (time) to be thinned out.
4108: A button for selecting to set the display value of the X axis to the absolute time.
4109: A button used to end the setting and change the display of FIG.
4110: A button used when canceling and returning to FIG.
4111: A button for designating whether to display preliminary (preparation) measurement data.
4112: A button for designating whether or not to display a mark.
4113: A button for setting the base line of the Y axis to 0.

FIG. 42 (Measurement Condition Display Input Screen) (S26)
4201: A bar for inputting a title (name of examination to be performed).
4202: A part for displaying the measured date and time, and the date and time when the screen is displayed is displayed by default (numbers and characters automatically displayed).
4203: A part for displaying and inputting the type of stimulation (for example, finger movement, writing, speech, drug administration, etc.).
4204: A part for displaying a measurement mode.
4205: A free memo writing portion.
4206: A part for displaying and inputting a subject name.
4207: A part for displaying and inputting the age of the subject.
4208: A part for displaying and inputting the sex of the subject.
4209: A part for displaying and inputting the type of the subject, that is, the patient or the healthy person.
4210: A part for displaying and inputting Burst Rate.
4211: A part for displaying and inputting the conversion rate.
4212: A part for displaying and displaying the number of samples acquired by one sampling.
4213: A part for displaying a data acquisition interval.
4214: A button for ending the setting. When this button is pressed, the screen returns to the screen shown in FIG.
4215: A cancel button. In the case of cancellation, the input value is not reflected and the screen display returns to the screen display shown in FIG.

FIG. 12 (input screen for measurement conditions and display conditions) (S27)
The meaning and function of each part are as already described (see S10).

FIG. 43 (additional average analysis processing time definition screen) (S28)
4301: When this button is pressed, an option menu is displayed, and the molecular extinction coefficient display screen and the fitting curve order setting screen (FIG. 45) shown in FIG. 44 can be selectively displayed as options.
4302: A box for inputting the pre-load time T1 in FIG.
4303: A box for inputting the relaxation time T2 in FIG.
4304: A button for inputting a time after load application in FIG.
4305: A box that displays the first mark position as a count value. That input is not possible.
4306: A box for displaying the second mark position as a count value. That input is not possible.
4307: A button used for finishing the setting and proceeding to the processing file addition setting screen shown in FIG.
4308: When this button is pressed with a cancel button, the screen returns to the mark edit screen and the mark edit auxiliary screen shown in FIGS.

FIG. 48 (Processing Time Definition Screen for Non-Additive Average Analysis) (S29)
In the case of the non-addition average analysis, unlike the addition average analysis, only the load time T1 in FIG. 26 is specified and the fitting curve is extrapolated.
4801: When this button is pressed, an option menu is displayed, and the molecular extinction coefficient display screen and the fitting curve order setting screen (FIG. 45) shown in FIG. 44 can be selectively displayed as options.
4302: A box for inputting the start count value or time of the load time T1 in FIG.
4803: A box for inputting an end count value or time of the load time T1 in FIG.
4804: A box for inputting an analysis start count value or time.
4805: A box for inputting an analysis end count value or time.
4806: A button used to finish the setting and proceed to the image creation confirmation screen shown in FIG.
4807: When this button is pressed with a cancel button, the screen returns to the mark edit screen and the mark edit auxiliary screen shown in FIGS.

  The meaning and function of each part will be described below with reference to FIGS. 44 to 46 that are selected and displayed on the processing time definition screen for addition average analysis and the processing time definition screen for non-addition average analysis shown in FIGS.

FIG. 44 (Molecular Absorption Coefficient Display Screen) (S30)
4401: A part for displaying the display range of the A / D conversion channel.
4402: A part for displaying an A / D conversion channel number.
4403: A part for displaying a wavelength allocated to each A / D conversion channel. When an arbitrary wavelength is input here, the molecular extinction coefficient corresponding to the wavelength is displayed in the portions 4404 and 4405.
4404: A part for displaying the molecular extinction coefficient of oxygenated hemoglobin corresponding to the wavelength indicated in the part of 4403.
4405: A part for displaying the molecular extinction coefficient of deoxygenated hemoglobin corresponding to the wavelength indicated in the part of 4403. Along with the molecular extinction coefficient displayed in the portion 4404, it is used for analysis calculation.
4406: A button used when ending and returning to the screen shown in FIG.
4407: Cancel button is selected. When this button is selected, the input changed value is not reflected, and the screen returns to the screen shown in FIG.

FIG. 45 (Fitting Curve Order Setting Screen) (S31)
4501: A box for designating and displaying the order of a fitting curve (measurement data approximate curve) used for calculating a hemoglobin change amount. The specified range is 0 to 9, and when the order is not specified, the value is automatically 2. When 10 to 19 are designated, 0 (when 10 is designated) to 9 (when 19 is designated) fitting curves are obtained from the period of the pre-load time T1 designated in FIG. When 99 is designated, the calculation is performed using the measurement signal in the T1 period as a baseline.
4502: A button for ending and returning to FIG. 43 or FIG.

FIG. 46 (processing file addition setting screen) (S32)
4601: By pressing this button, the measurement data of another file can be integrated in the addition average analysis. When this button is pressed, the screen returns to the file reading screen shown in FIG. 34 and passes through FIGS. 35 and 36 and FIG. 43 again. However, the setting of FIG. 43 cannot be changed after the second time.
4602: When this button is selected, the hemoglobin concentration is calculated, and the image creation confirmation screen shown in FIG. 47 is displayed (S33).

In FIG. 47, the meaning and function of each part are as follows.
4701: When this button is pressed, the process proceeds to topograph generation (screen creation) processing. That is, the topographic condition setting screen (1) shown in FIG. 49 or the topographic condition setting screen (2) shown in FIG. 50 is displayed (S34).

4702: When this button is pressed, the process proceeds to a process for saving analysis data. That is, first, the analysis condition display screen shown in FIG. 66 is displayed (S35). When the cancel button 6608 in the screen of FIG. 66 is pressed, the screen returns to the screen 47, and when the end button 6607 is pressed, the same screen as shown in FIG. 40 is displayed (S36), and the processed result is saved as a file. Details of the analysis condition display screen shown in FIG. 66 will be described later. In FIG. 40, when save 4009 is selected, the screen returns to the screen shown in FIG. 32 after saving the file, and when cancel 4010 is selected, the screen returns to the screen shown in FIG.
4703: Pressing this button simply returns to the screen shown in FIG.

49 and 50, the screen shown in FIG. 49 is displayed when the Parameter tab is pressed, and the screen shown in FIG. 50 is displayed when the A / D CH Combination tab is pressed. 49 and 50, the meaning and function of each part are as follows.
4901: A part for designating hemoglobin data to be imaged as a topograph.
4902: A part for selecting whether or not to perform statistical processing. That is, selection of None means that a topography image is created without performing statistical processing, and selection of Mahalanobis means that a topography image is created by performing statistical processing. Statistical processing is performed using signal fluctuation as a variable, and representative processing includes test processing such as t-test.
4903: A part for designating a measurement channel position setting method. That is, Auto selection means automatic assignment, and Manual selection means manual input. The number of measurement faces can be specified by putting a number in a box called Number of Face.
4904: A part for designating an averaging method as follows.
Natural: If selected, no averaging operation is performed.
Average: When this is selected, the averaging operation is performed for each specified count on the horizontal axis. As the value to be entered in the Averaging Counts box, specify the count to be averaged on the horizontal axis. In the Splitting Count box, averaging is performed for each value entered in the Averaging Counts box on both sides of the count value entered here.
Moving Average: Select this to perform a moving average operation. In the Averaging Counts box, you can enter the number of moving average points (this is generally called the number of periods).
4905: A setting end button. In this case, when Manual is selected in the portion 4903, the topographic image creation light irradiation and detection position setting screen shown in FIG. 51 is displayed (S37). When Auto is selected, the topographic image creation editing shown in FIG. 53 is displayed. And a display screen is displayed (S39).
4906: A cancel button.
5001: A part for designating a combination of A / D conversion channels. When three or more wavelengths are used for each measurement channel, a combination of two wavelengths used for hemoglobin concentration calculation can be designated here.

In FIG. 51, the meaning and function of each part are as follows.
5101: A part for inputting and displaying the title of the graph.
5102: A part for setting a light irradiation and a detection position by inputting a check mark. If you double-click inside the white square with the mouse, you can switch on / off the check mark.
5103: By pressing this button after setting the light irradiation position and the detection position, the screen display is switched from the screen of FIG. 51 to the measurement position setting screen for creating the topographic image shown in FIG. 52 (S38).
5104: When this button is pressed, the screen display is switched from the screen of FIG. 51 to the screen of FIG.
5105: A button for displaying the set light irradiation position and detection position.
5106: A button for hiding the set light irradiation position and detection position.
5107: A button for displaying the set measurement channel.
5108: A button for hiding the set measurement channel.
5109: When this button is pressed, buttons 5103 to 5108 are displayed.
5110: When this button is pressed, buttons 5103 to 5108 are hidden.

  In FIG. 52, the lower part is the same as the lower part of FIG. Reference numeral 5201 denotes a part for inputting a measurement channel number. By double-clicking the left mouse button, the internal counter is incremented by 1, and numerical values are automatically entered in order. Conversely, the internal counter is decremented by 1 by single-clicking the left mouse button while holding down the Shift key.

FIG. 53 shows a screen used for creating a topographic image of Hb concentration from a measured time-series signal, displaying a still or moving image, and further storing it. Here, an example in which one image is displayed is shown, but it is also possible to display a plurality of images simultaneously. In FIG. 53, the meaning and function of each part are as follows.
5301: By pressing this, the File menu shown in FIG. 54 can be called.
The File menu includes Load Topogrtaph Image (to load a saved topography image), Save Topograph Image (to save a created topography image), and Load Mode Data (to load a mode file: mode at the time of measurement) There is an option of condition data representing. When Load Topograph Image is selected, a topographic image reading screen shown in FIG. 61 or 62 is displayed (S40). When Save Topograph is selected, a topography image saving screen shown in FIG. 63 or 64 is displayed (S41). When Load Mode Data is selected, the file reading screen shown in FIG. 40 is displayed (S42).
5302: By pressing this button, the Edit menu shown in FIG. 55 can be called. The Edit menu has options for Graph1 copy, Graph2 copy, and Range copy. When Graph1 copy is selected, the image of surface 1 is copied, when Graph2 copy is selected, the image of surface 2 is selected, and when the range copy is selected, the color range is copied to the temporary storage area of the computer.
5303: When this button is pressed, an Option menu shown in FIG. 56 can be called. The Option menu has Set color, Setup Parameter, and Condition options. When Set color is selected, the display color setting screen shown in FIG. 65 is displayed (S43), and when Condition is selected, FIG. 66, 67 or 68 is displayed (S44).
5304: When Topograph Control is in the Manual mode, this is a portion for inputting the time at which an image is to be created on the time axis of the hemoglobin concentration change data set in FIG. When Topograph Control is in the Auto mode, it is also a part for displaying the processing time during the image creation process and the time of the displayed image during the display of the already created image.
5305: When Topograph Control is Auto mode and Create All, enter the start time (left frame) and end time (right frame) of image creation on the time axis of the set hemoglobin concentration change data This is the part to be displayed.
5306: A part indicating a processing state. Red during data processing (Topograph generation), green otherwise.
5307: An area for displaying the created topography image.
5308: A topographic display color range (contrast width) (a color bar indicating a correspondence between a hemoglobin density value and a color).
5309: A portion for displaying the maximum value (upper frame) and the minimum value (lower frame) of the hemoglobin density value corresponding to the display color of the topography image. In addition, by turning on the Set Max-Min value check (see FIG. 57 (described later)), the operator can specify the maximum value and the minimum value.
5310: A part for displaying the position (time) and range of the processing data. The entire horizontal axis indicates the period during which an image can be created. When the image creation process and image display are in progress, the red vertical line moves in synchronization with the time of the displayed image. When a vertical line crosses a mark whose graphic shape is a triangle, it changes the background color of the sound or image and transmits it to the operator. When the image creation period is set in the portion 5305, the range is displayed with a light blue horizontal line. A range between marks (see FIG. 35) is displayed in yellow. However, when Average is selected in Average Mode on the topograph condition setting screen shown in FIG. 49, the Split Count position is displayed.
5311: When this button is pressed, a topographic image is created. In the Manual mode, one image of the time in the 5304 time area is generated. In Auto mode and Create All, an image in the time range set in the portion 5305 is displayed. At this time, the creation range is displayed in a light blue horizontal line in the 5310 area.
5312: When this button is pressed, the topograph generated by the Auto mode and Create All is displayed again.
5313: By pressing this button, the playback image is paused. Press again to continue playback.
5314: A part for designating an image display interval at the time of moving image reproduction.
5315: When this button is pressed, the topography creation and the replay button are pressed again to cancel the display process.
5316: Pressing this button closes the topograph screen.
5317: When this button is pressed, an image at the next sampling time is created and displayed in the Manual mode. In the Auto mode and Create All, the image at the next sampling time of the currently displayed image is displayed within the time range in which the image was created. This means frame advance.
5318: Pressing this button is the opposite of pressing the 5317 button (previous image).
This means frame back.
5319: A part for selecting a mode for creating a topograph. In the Auto mode, an image of a specified range can be generated at one time, and in the Manual mode, one screen is generated.
5320: When this button is pressed, a created image type setting screen shown in FIG. 60 is displayed (S45), and a plurality of topographic images are created and stored as files according to the conditions set on this screen. Here, the stored image can be read and displayed later.

57 and 58 are excerpts from the lower left part of the screen shown in FIG. 57 shows a creation screen condition setting tab screen, and FIG. 58 shows a display image type selection tab screen. When the Image Control button is pressed, the screen of FIG. 57 appears, and when the Created Image button is pressed, the screen of FIG. 58 appears. In these drawings, the meaning and function of each part are as follows.
5701: A button for selecting a dynamic (moving image) or static (still image) topograph. This setting is ignored when the Create All button is pressed.
5702: A part for inputting a check mark by double-clicking when the maximum and minimum values of the hemoglobin concentration corresponding to the color display color of the topograph are arbitrarily designated.
5703: A part for inputting the resolution of the topography image.
5704: A part for designating the background color of the topograph. Color type is Black, Gray
There are three types, White.
5705: When an image in a time range surrounded by a mark is displayed, if the background color is to be yellow, a check mark is input in this portion.
5801: A part for displaying the type (Oxy, Deoxy, Total, Dynamic, Static, Color, or Monochrome) of the topographic image generated by pressing the Create button. C indicates Color, M indicates Monochrome, and R indicates whether the color of the color is upside down. If there is a type of the created image (the type of image is specified on the screen of FIG. 60 after pressing the Create All button), the image type can be selected, and Replay and Before in the screen of FIG. 53 are selected. Press the Next button to display the image.

  FIG. 59 shows a two-screen topography image creation editing and display screen displayed instead of the screen of FIG. 53 when there are two measurement areas (surfaces). Reference numeral 5901 denotes a part for displaying the title of the second screen. For example, the left and right hemispheres of the subject may be measured separately, and the left and right changes may be displayed simultaneously on one screen. Furthermore, when playing back moving images, a plurality of moving images can be played back and displayed in synchronization. Reference numeral 5902 denotes a button group used for measuring and positioning the second screen. These button groups are the same as the buttons 5103 to 5108 in FIG. Reference numeral 5903 denotes a selection portion for selecting a screen of an image to be processed. Only the first screen is processed when Face1 is selected, only the second screen is processed when Face2 is selected, and both the first screen and the second screen are processed when Both is selected.

  The meaning and function of each part of the screens of FIGS. 60 to 68 selected and displayed in FIGS. 53 and 59 will be described below.

FIG. 60 (Created Image Type Setting Screen) (S45)
On this screen, the type of topography image to be generated can be specified. Specifically, it is as follows.
6001: A part for inputting a check mark when an image of Oxy-Hb (oxygenated hemoglobin) is generated.
6002: A part for inputting a check mark when an image of Deoxy-Hb (reduced hemoglobin) is generated.
6003: A part for inputting a check mark when generating an image of Total-Hb (total of oxidized hemoglobin and reduced hemoglobin).
6004: A button to be pressed when proceeding to image generation processing.
6005: Cancel button. When this button is pressed, the screen returns to the screen of FIG.

61 and 62 (topography image reading screen) (S40)
With these images, the topography image data directory to be read can be designated. Specifically, it is as follows.
6101: When this tab is pressed in the Condition tab, the screen shown in FIG. 61 appears.
6102: A part for displaying information of image data to be read. This is the same as FIG. However, Analyze Mode means the mode (Integral or Continuous) when processed.
6103: When this button is pressed, reading of image data to be read is started. A name (which is stored as a directory name) is displayed or entered.
6104: When this button is pressed with a cancel button, the screen of FIG. 53 is restored.
6105: Display or input the name of the image data to be read (this is saved as a directory name). Information of the image data designated here is displayed in a portion 6102.
6106: A part for displaying and selecting a directory or image data name. A directory can be selected by clicking, and the path name of the designated directory is displayed in the portion 6105.
6107: A part for selecting a storage medium to be read (floppy (registered trademark) disk, hard disk, MO, etc.). A directory inside the designated storage medium is displayed in a portion 6106.
6201: When this tab is pressed in the Image File Location tab, the screen shown in FIG. 62 appears.
This is a part for displaying the file name and the like in the directory designated in the part 6202: 6105.

63 and 64 (topography image storage screen) (S41)
With these images, it is possible to specify a storage destination directory for the topographic image data. Specifically, it is as follows.
6301: When this tab is pressed in the Condition tab, the screen shown in FIG. 63 appears.
6302: A part for displaying information of topographic image data to be stored.
6303: A button for saving topography image data in a designated directory.
6304: When this button is pressed with a cancel button, the screen of FIG. 53 is restored.
6305: A part for displaying and inputting a directory to be stored.
6306: When this button is pressed, a new directory with the directory name input in 6307 is created under the directory specified in the portion 6305.
6307: A part for inputting a directory name to be newly created.
6308: A part for displaying and selecting a directory. By clicking, a directory can be selected, and the designated directory is displayed in the portion 6305.
6309: A part for selecting a drive. The directory of the designated drive is displayed in the portion 6308.
6401: When this tab is pressed in the Image File Location tab, the screen shown in FIG. 64 appears.
6402: A part for displaying the data structure of the topographic image data to be stored.

  63 and 64, 6306 and 6307 are added to the screens of FIGS. The other parts are only saved for reading in the screens of FIGS.

FIG. 42 (file reading screen) (S42)
The contents of the screen are as already described (see S22).

FIG. 65 (display color setting screen) (S43)
On this screen, the color scheme of the colors shown in FIGS. 53 and 59 can be set to set the color of the topography image. Specifically, it is as follows.
6501: A part for displaying a set color bar. When the setting is changed in this screen, the color arrangement in this color changes in synchronization.
6502: This vertical line can be moved left and right with the mouse. The color scheme along the vertical line is the color scheme of the color 6650. Different color schemes are defined depending on the position of the horizontal axis in the area (color scheme selection area) where the vertical line moves.
This is a portion for displaying a gradation change of black and white display when grayscale display is selected in the portion of 6503: 6505.
6504: A portion for displaying the horizontal axis position of the vertical line position in the color scheme selection area as a numerical value. When a numerical value is input here, the color scheme selected by moving the vertical line to the corresponding position in the color scheme selection area changes.
6505: A part for designating a gray scale. When a check mark is entered, a topographic image is generated on a gray scale.
6506: A button for reversing the color balance (up and down).
6507: This is a portion for setting the ratio of the color scheme (gradation in the case of monochrome) selected by the vertical line of 6502 by changing the tone curve. As a method, the curve is adjusted by dragging three points on the tone curve with the mouse.
6508: A part for displaying X coordinates of three points of the tone curve. When a numerical value is input to this part, the turn curve also changes corresponding to the numerical value.
6509: A part for displaying Y coordinates of three points of the tone curve. When a numerical value is input to this part, the turn curve also changes corresponding to the numerical value.
6510: A button for returning the color tone curve to the initial state (straight line).
6511: When this button is pressed, the setting contents are reflected in the topography image.
6512: A button to be pressed when the color setting is completed. When this button is pressed, the screen returns to the screen of FIG.

FIG. 66 (Analysis condition display screen) (S44)
This screen is a screen on which the measurement conditions and analysis conditions of the image file to be saved can be displayed and edited.
6601: Condition tab When this tab is selected, the screen shown in FIG. 66 appears.
6602: A part for inputting and displaying the title of the analysis file.
6603: A part for displaying an analysis mode (Inrtegral or Continuous).
6604: A part for displaying a measurement mode.
6605: A part for displaying a file name and a data processing range of data used for analysis.
In the case of the Integral mode, it is also a part for displaying information on the mark used for integration.
6606: A part for inputting and displaying a memo of the analysis file.
6607: A button for ending.
6608: A cancel button.
6609: A part for displaying the date and time of the analysis file. Automatically inserted.
6610: A part for displaying the type of stimulus (see FIG. 42).
6611: A part for displaying the number of measurement channels.
6612: A part for displaying the number of wavelengths.
6613: A part for displaying wavelength data.

67 and 68 are screens having tabs common to the screen of FIG. 66, FIG. 67 is a measurement file condition display screen when the Information of Each Files tab is selected, and FIG. 68 is a topographic image when the Topograph Parameter tab is selected. It is a creation condition screen. The screen in FIG. 67 is a screen for displaying the conditions of the measurement file used for analysis (image creation). The meanings and functions of the respective parts in FIGS. 67 and 68 are as follows.
6701: By selecting this tab on the Information Of Each Files tab, the screen shown in FIG. 67 appears.
6702: A part for displaying a measurement file name used for analysis. By selecting the file name used for the analysis, the measurement information of the selected file is displayed in the portions 6703 to 6709.
6703: A part for displaying data of the subject (name, etc., see FIG. 42).

6704: A part for displaying measurement parameters (A / D transformer set value, sampling interval, etc.). It is almost the same as FIG.
6705: A part for displaying a title (see FIG. 42).
6706: A part for displaying the measurement date and time (see FIG. 42).
6707: A part for displaying the type of stimulus (see FIG. 42).
6708: A part for displaying a measurement mode (see FIG. 42).
6709: A part for displaying memo data (see FIG. 42).
6801: When this tab is selected in the Topograph Parameter tab, the screen shown in FIG. 68 appears.
6802: A part for displaying the resolution of the image (value specified in 5703 in FIG. 57).
6803: A part for displaying a processing type (value designated by 4902 in FIG. 49).
6804: A part for displaying the averaging method in the time axis direction (see 4904 in FIG. 49).
6805: A part for displaying the type of image to be stored (see FIG. 60).
6806: A part for displaying the length of the analysis possible time range.
6807: Dynamic topograph image start and end time (upper row), image start and end count (lower row), mark time and count, and the number of created images (bottom row).
6808: A portion for displaying data of color balance point (see 6504 in FIG. 65) and reverse (see 6506 in FIG. 65).
6809: A portion for displaying a Max value and a Min value of density change of the Dynamic topograph and the Static topograph (see 5009 in FIG. 53).
6810: A part for displaying the points of the turn curve (see 6508 and 6509 in FIG. 65).
6811: A part for displaying a combination of A / D conversion channels (see 5007 in FIG. 50).

  FIG. 95 shows a display flow as an example based on the present invention when data display after data analysis is performed using the optical measuring device shown in FIG. Details regarding the display will be described later with reference to FIGS. 69 to 91, but as can be seen from the display flow of FIG. 95, when displaying, the program of the optical measuring device is generally started in step 951. The screen transitions as in steps 952 to 955, and the display ends in step 956.

95, the screen displayed in step 952 is a screen shown in FIG. 70 described later, and the display mode is selected here. The screen displayed in step 953 is a screen displayed in FIG. 34, which will be described later. Here, the stored data file can be read.
The screen displayed in step 954 is a screen shown in FIG. 71 to be described later. Here, a graph to be displayed is selected, and the selected graph is displayed in step 955 as shown in FIGS. The
In this case, the display graph selection screen of FIG. 71 and the graph selected by the operator (for example, the topographic image display screen of FIG. 52 and the hemoglobin concentration graph mapping display screen of FIG. 91) are displayed on one screen as shown in FIG. can do. According to this, it is possible to intuitively grasp the measurement position shown in FIG. 52 and the hemoglobin concentration time waveform corresponding to each measurement position. If necessary, the screen of FIG. 52 and the screen of FIG. 91 may be set to be displayed in pairs on the same screen.

  FIG. 69 shows the measurement data graph, fitting curve (baseline), and hemoglobin after the above-described subject measurement processing and data analysis processing using the optical measurement apparatus shown in FIG. An exemplary flow according to the present invention for displaying necessary data such as a series graph, topographic image, etc. is shown. After the measurement process and the data analysis process are completed, when the user returns to the initial menu for menu selection shown in FIG. 3 and presses the button 302 in the initial screen, the initial screen shown in FIG. The process selection screen shown in FIG. 32 is displayed. (S50). The meaning and function of each part in FIG. 32 are as described above. In FIG. 32, when the button 3202 is pressed, the graph menu screen shown in FIG. 70 is displayed (S51).

  In FIG. 70, 7001 is a button for reading measured data, and 7002 is a button for reading analysis data. When one of the buttons is pressed, a file reading screen shown in FIG. 34 is displayed (S52). . Reference numeral 7003 denotes a button for reading analysis data including a topography image. When this button is pressed, a topography image reading screen shown in FIG. 61 is displayed (S53). Reference numeral 7004 denotes a button for closing the menu. When this button is pressed, the screen display returns to the screen shown in FIG. When the button 3408 in the screen of FIG. 34 or the button 6103 in the screen of FIG. 61 is pressed, a display graph selection screen shown in FIG. 71 is displayed (S54).

The meaning and function of each part in FIG. 71 are as follows.
7101: A button for displaying a graph of measured time series data. Graphs of measurement data of a plurality of A / D converter channels can be displayed simultaneously. By pushing this button, the graph display adjustment screen is displayed (S55). This graph display adjustment screen is the same as the mark editing graph display adjustment screen shown in FIG. 41 (only the name is different). When the button 4109 or 4110 is pressed on this screen, the measurement data graph display screen shown in FIG. 73 is displayed (S56). 73, reference numeral 7301 denotes a button for calling an Option menu shown in FIG. 74, and reference numeral 7302 denotes an area for displaying measurement data in a graph. In FIG. 74, pressing the Setup Parameter button returns to the screen shown in FIG. After the button 7101 is pressed, FIG. 71 changes to the state shown in FIG.
7102: A button for proceeding to a step of displaying a fitting curve (baseline) and measurement data in a graph (hereinafter referred to as a fitting graph). When this button is pressed, a fitting graph display condition screen shown in FIG. 75 is displayed (S57).
7103: A button for proceeding to a step of displaying time series data of hemoglobin in a graph. When this button is pressed, a hemoglobin concentration graph display condition setting screen (described later) shown in FIG. 88 is displayed.
7104: A button for proceeding to a step of displaying a topographic image. When this button is pressed, the screen returns to the topographic image creation editing and display screen shown in FIG.
7105: A button for ending the graph display. When this button is pressed, the screen of FIG. 70 is displayed.

  Reference numeral 7201 in FIG. 72 denotes a button for selecting each graph number when displaying a graph of measurement data of a plurality of A / D converter channels. Options are from Graph 1 to Graph n (n is the maximum A / D converter channel number). Before the graph display, the graph display adjustment screen shown in FIG. 41 is displayed.

FIG. 75 shows a screen displayed by pressing a button 7102 on the screen of FIG. On the same screen, the meaning and function of each part are as follows.
7501: A button for selecting whether to display the X-axis by time or sampling count.
7502: A button for designating whether or not to display a mark.
7503: A part for designating the Y-axis range of the graph. Specifically, it is as follows.
Auto (uniform): When displaying multiple graphs, the maximum and minimum values are automatically unified to the optimum value.
Auto (separate): When displaying multiple graphs, the maximum and minimum values are automatically set to optimum values for each graph.
Manual: Manually specify the maximum and minimum values of the Y axis.
7504: When this button is pressed, a file reading screen shown in FIG. 34 is displayed (S58), and a measurement mode file can be read from the screen. When a cancel button 3401 in the screen of FIG. 34 is pressed, the screen of FIG. 75 is restored.
7505: A button for manually setting the position of the measurement channel. When this button is pressed, the measurement mode setting screen shown in FIG. 76 is displayed (S59), and then the measurement channel position editing screen shown in FIG. 77 is displayed (S60).
7506: A button for ending the setting. When this button is pressed, a fitting graph display screen shown in FIG. 84 is displayed (S61).
7507: Cancel button. Even if this button is pressed, the fitting graph display screen shown in FIG. 84 is displayed.
7508: The position of the measurement channel is a display area. If there is measurement position data, the measurement channel number is displayed. When the mouse cursor is moved over the measurement channel number, the channel number of the A / D converter corresponding to each measurement channel is displayed under the mouse cursor. If there is no measurement channel position data, the measurement channel number is not displayed. In this case, it is necessary to input measurement channel position data by pressing a button 7504 or 7505.

As described above, when the button 7505 in the fitting graph condition setting screen shown in FIG. 75 is pressed, the measurement mode setting screen shown in FIG. 76 is displayed. On the screen, the meaning and function of each part are as follows.
7601: A button for selecting or inputting the number of wavelengths used in the measurement channel.
7602: A button for selecting the number of faces in the measurement area.
7603: A button for inputting the number of measurement channels for each measurement surface.
7604: A button for ending the setting. When this button is pressed, a measurement channel position editing screen shown in FIG. 77 is displayed.
7605: A button for canceling the setting. When this button is pressed, the screen returns to the screen of FIG.
In the measurement channel position editing screen shown in FIG. 77 displayed by pressing a button 7604 in the screen of FIG. 76, the meaning and function of each part are as follows. 7701: A button for calling the File menu in FIG.
7702: A part for inputting a label (arbitrary name) on the side face.
7703: A button for checking the incident and detection positions.
7704: When this button is pressed after checking with the button 7703, the screen changes to a measurement channel position edit screen shown in FIG.
7705: A part for inputting the number of measurement channels.
7706: A portion (grid) for displaying wavelength data for each channel of the A / D converter.
7707: A part for inputting wavelength data.
7708: A button for displaying the wavelength input screen shown in FIG. This is used when inputting wavelengths to the wavelength grid 7706 at once.
7709: A part for inputting an arbitrary sentence (memo).
7710: A button for ending editing. When this button is pressed, the button returns to the screen shown in FIG.
7711: A button for canceling the setting. When this button is pressed, the screen returns to the screen shown in FIG.

As described above, when the button 7704 is pressed, the screen shown in FIG. 77 is changed to the screen shown in FIG. On the screen, the meaning and function of each part are as follows.
7801: An area for inputting a measurement channel number. In addition to directly entering numerical values in this area, double-clicking on the area can automatically increase the numerical value by one. At this time, the internal counter can be reset to 1 by clicking the left mouse button while holding down the Shift key.
7802: An area for inputting an A / D channel number. Multiple channel numbers are entered by separating them with "," (example: 1, 2). In addition to entering numbers directly in this area, double-clicking on the area automatically increases the number by one. At this time, the internal counter can be reset to 1 by clicking the left mouse button while holding down the Shift key.
7803: When this button is pressed, the screen shown in FIG. 77 is restored.

  FIG. 78 shows the measurement channel position editing screen when there is one measurement surface, but the measurement channel position editing screen when there are two measurement surfaces is different from that when there is one. FIG. 79 shows an example of a measurement channel position editing screen corresponding to FIG. 78 when there are two total side faces.

  FIG. 80 shows a File menu screen called up by pressing a button 7701 on the screen of FIG. The File menu has options for New, Open, and Save As. When each option is selected, the measurement mode setting screen shown in FIG. 76 (when New is selected), the file reading screen shown in FIG. 82 (when Open is selected), and the file saving screen shown in FIG. 83 (save as selection) Is displayed.

  FIG. 81 shows a wavelength input screen displayed by pressing a button 7708 in the screen of FIG. In the figure, reference numeral 8101 denotes a part for inputting a wavelength, 8102 denotes a button for ending the setting, and 8103 denotes a button for canceling the setting.

FIG. 82 shows a file reading screen displayed by selecting Open on the file menu screen of FIG. In the figure, the meaning and function of each part are as follows.
8201: An area for inputting a file name.
8202: This area displays a list of file names in the directory selected in area 8203. Here, the selected file name is automatically displayed in the area 8202.
8203: An area for displaying the hierarchical structure of the directory.
8204: A button for reading the file selected in the area 8202. 8205: A button for canceling.
8206: A part for designating a file type.
8207: A part for designating a drive.
The specified file name is saved in the initialization file when the OK button is pressed, and the same data is displayed at the next activation.
FIG. 83 shows a file save screen displayed by selecting Save As on the File menu screen of FIG. The contents of the screen are the same as in FIG. However, when the OK button is pressed, the result edited in FIG. 77 is saved as a file on this screen. Saved files can be reused by loading them as needed. The specified file name is saved in the initialization file when the OK button is pressed, and the same data is displayed at the next startup.

  77 to 83 (excluding FIG. 80), the screen returns to the screen of FIG. 75 by pressing the OK button, or pressing the Cancel or Cancel button.

As described above, when the button 7506 or 7507 in the fitting graph display condition setting screen shown in FIG. 75 is pressed, the fitting graph display screen shown in FIG. 84 is displayed. In the figure, the meaning and function of each part are as follows. 8401: A button for calling the Edit menu shown in FIG.
8402: A button for calling an Option menu shown in FIG.
8403: An area for displaying a fitting curve formula.
8404: An area for displaying a square error obtained when a fitting curve is obtained.
8405: A part for displaying or selecting the channel number of the A / D converter of the measurement data displayed as a graph. When the channel number of the A / D converter is changed, the graph is updated.
8406: A part for displaying the measurement wavelength.
8407: An area for displaying measurement data and a fitting curve graph (baseline).

  FIG. 85 shows the Edit menu screen displayed by pressing the button 8401 in the screen of FIG. 84 as described above. When Copy is selected on this screen, the fitting graph is copied to the clipboard.

  FIG. 86 shows the Option menu screen displayed by pressing the button 8402 in the screen of FIG. 84 as described above. The Option menu includes Setup Parameter, Mapping Image, and Condition menu. When Setup Parameter is selected, the fitting graph display condition setting screen shown in FIG. 75 is displayed. When Mapping Image is selected, the fitting graph mapping display screen shown in FIG. 87 is displayed (S62), and when Condition is selected, FIG. 66 is displayed. The displayed analysis condition display screen is displayed (S63). In the screen of FIG. 87, 8701 is an area for displaying a fitting graph of the A / D converter channel corresponding to the measurement position. Here, the fitting graph of the A / D converter channel corresponding to the measurement position is displayed in correspondence with the actual measurement position. This screen is displayed on a different screen for each wavelength, or displayed with a different color for each different wavelength. Of course, the line type may be changed. When the buttons 6607 and 6608 in the screen of FIG. 66 are pressed, the screen of FIG. 84 is restored.

When the button 7103 in the screen shown in FIG. 71 is pressed, a hemoglobin concentration graph display condition setting screen shown in FIG. 88 is displayed (S64). In FIG. 88, the meaning or function of each part is as follows.
8801: A part for checking the type and mark of hemoglobin data to be displayed as a graph.
8802: Condition / Position selection tab.
8803: A part for designating the Y-axis range of the graph. Specifically:
Auto (uniform): When displaying multiple graphs, the maximum and minimum values are automatically unified to the same optimal value for all graphs.
Auto (separate): When displaying multiple graphs, the maximum and minimum values are automatically set to optimum values for each graph.
Manual: Manually specify the maximum and minimum values of the Y axis.
8804: A part for selecting whether to display the X-axis by time or sampling count.
8805: A part for specifying an averaging method in the time direction. Specifically, it is as follows.
Natural: Do not average.
Average: Performs averaging operation for each specified count. Specify the number of counts to average here. For Splitting Count, specify the point where the averaging operation is not performed across the points.
Moving Average: Performs moving average operation. Specify the number of moving average points in Averaging Counts.
When 8806: none is selected, data not subjected to statistical processing is displayed as a graph, and when Mahalanobis is selected, data subjected to statistical processing is displayed as a graph.
8807: When this button is pressed, a file reading screen shown in FIG. 34 is displayed (S65), and a measurement mode file can be read from this screen to specify the position of the measurement channel.
8808: A button for manually setting the position of the measurement channel. When this button is pressed, a measurement mode setting screen shown in FIG. 76 is displayed (S66). From this screen, the measurement channel position editing screen shown in FIG. 77 can be displayed (S67). In S67, the screens shown in FIGS. 77 to 83 can be displayed, and the same contents as in S60 can be executed. In S67, the OK button in the screens of FIGS. 77 to 83 (excluding FIG. 80) is pressed, or the Cancel or Cancel button is pressed to return to the screen of FIG.
8809: A setting end button. When this button is pressed, the hemoglobin concentration display screen shown in FIG. 90 is displayed.
8810: A cancel button. Even if this button is pressed, the screen shown in FIG. 90 is displayed.
8811: 8 areas for displaying the positions of measurement channels. If there is measurement position data, the measurement channel number is displayed. When the mouse cursor is moved over the measurement channel number, the A / D converter channel H number corresponding to each measurement channel is displayed under the mouse cursor. If there is no measurement channel position data, the measurement channel number is not displayed. In this case, it is necessary to input measurement channel position data by pressing a button 8807 or 8808.

FIG. 89 shows another hemoglobin graph display condition setting screen. The meaning and function of each part are as follows.
8901: This is the CH Parametr selection tab. This tab is the same as that on the screen of FIG. 88. When this tab is selected on the screen of FIG. 88, the screen of FIG. 89 is displayed, and when Condition / Position is selected on the screen of FIG. 89, the screen of FIG. 88 is displayed. The
When 8902: measure CH is selected, a measurement channel number can be input in area 8904, and when A / D CH Combination is selected, a combination of A / D converter channels can be input in area 8903.
8903: An area for designating a combination of two or more A / D converter channels for calculating the hemoglobin concentration in the measurement channel designated in the area 8904.
8904: An area for specifying the number of a measurement channel to be displayed in a graph.

As can be seen from the above, when the button 8809 or 8810 in the screen of FIG. 88 is pressed, the Robin concentration display screen shown in FIG. 90 is displayed (S68). In FIG. 90, the meaning and function of each part are as follows.
9001: A button for calling up an Edit menu shown in FIG.
9002: A button for calling an Option menu shown in FIG. When Condition in the Option menu is selected, an analysis condition display screen shown in FIG. 66 is displayed (S69). If the buttons 6607 and 6608 in the screen of FIG. 66 are pressed, the screen of FIG. 90 is restored. When “Mapping Image” in the Option menu shown in FIG. 86 is selected, the hemoglobin concentration display screen shown in FIG. 91 is displayed (S70). In FIG. 91, reference numeral 9101 denotes an area for displaying a graph showing a temporal change in hemoglobin concentration corresponding to the measurement position. Here, the temporal change in hemoglobin concentration corresponding to the measurement position is displayed corresponding to the actual measurement position.
9003: An area for displaying a graph of hemoglobin concentration.

  In FIG. 90, legends such as / oxy-Hb, / deoxy-Hb, and / total-Hb are shown, but these indicate the chemical species and the corresponding line color or line type (slant part). ing.

  For all the screens described above, when the upper bar of the display screen is double-clicked, a Print command is displayed, and printing is executed by selecting the command.

  As mentioned above, although the Example of this invention was described in detail, when the characteristic point of the optical measuring device by this invention is listed here, it is as follows. However, these should not be understood as all of the features.

1) When displaying a plurality of time change graphs at the time of measurement and data analysis, the display is performed by changing the line color or line type for each measurement wavelength or measured chemical species (FIGS. 14, 26, 27, 73, 84, 87, 90, 91 etc.).
1a). There is a means to input a mark automatically or manually at the time of measurement, and this mark is displayed on the plurality of graphs in a color or line type different from the color or line type of the graph (FIGS. 10, 14, etc.) .
1aa) The mark position (time) input at the time of measurement can be added, deleted, and moved after the measurement (FIG. 35, etc.).
1b) When displaying a plurality of time-series graphs, the graphs are displayed at positions that reflect the measurement positions of the acquired signals (FIGS. 87, 91, and 96).
1c) When displaying multiple time series graphs, specify that one of the two coordinate axes is to be displayed with the same value, or that the vertical axis is to be displayed with the optimum value for each graph. It has a screen (FIGS. 87, 88, 91, etc.).

2). At the time of measurement, it has a screen that displays the time from the start of measurement and the time from mark input (FIG. 19 etc.).

3) It has a screen to specify that signals from other devices are taken during measurement (Fig. 17 etc.).

4). It has a screen to specify that measurement is performed in response to an external trigger signal (FIG. 20).

5). It has means for outputting an arbitrary waveform signal to the outside, and has a screen for setting its waveform shape and time interval (FIGS. 18, 19, etc.).

6). Memorize the variables set at the time of the previous measurement and analysis, and display them by replacing or adding the variables at the time of the next measurement and analysis.

7) It has a screen for setting as follows (FIGS. 12, 76, 77, 78, 79, 81, etc.).
7a). It has a screen for designating the relative relationship between the measurement position and the internal address holding the signal measured at the measurement position.
7b). It has a screen for setting the relative relationship between the measurement position or the internal address that holds the signal measured at the measurement position and the wavelength used for measurement or the extinction coefficient of the measurement object.

8). It has a screen for displaying a plurality of measurement positions and a plurality of light incident and condensing positions at the time of measurement or analysis (FIGS. 6, 52, 96, etc.).
8a) A screen that displays a plurality of measurement positions and a plurality of light incident and condensing positions that are displayed during measurement or analysis, depending on the state of each signal at each measurement position or light incident and condensing position. It has a function of displaying the state of each signal by a symbol or a number (FIGS. 6, 52, 96, etc.).

9). A screen for selecting whether to display or hide a plurality of measurement positions and a plurality of light incident and condensing positions on the created image (FIGS. 52, 59, etc.).

10) .It has a screen that displays the created image as a moving image, and when displaying the moving image, the part that displays the time of the displayed image as a number and the entire moving image playback time range are displayed in a rectangular area, and inside that area It has a screen for displaying the time corresponding to the display image with a line (FIG. 53).
10a) A moving image playback screen has a screen including a part for specifying playback stop, playback pause, frame advance, frame reverse, and repeat playback (FIG. 53, etc.).
10b) A screen for displaying a plurality of images synchronously on a moving image playback screen (FIG. 59, etc.).
10c) On the moving image playback screen, a rectangular area for displaying the entire moving image playback time range has a screen for displaying a graphic representing the mark input time input at the time of measurement (FIG. 53, etc.).
10ca). When there are a plurality of figures representing the mark input time input at the time of measurement in the rectangular area portion that displays the entire moving image playback time range, a screen that displays the section between the marks in a different color (FIG. 53, etc.) ).
10d) On the moving image playback screen, a sound is generated when the line representing the time of the display image in the rectangular area portion displaying the entire moving image playback time range crosses the mark (FIG. 53, etc.).
10e) A screen that has the function of changing the background color of the screen when the line that represents the time on the display screen in the rectangular area that displays the entire video playback time range intersects the mark on the video playback screen. (FIG. 53 etc.).

11) The image display screen has a screen including a part for setting the contrast width and hue of the display screen (FIGS. 53, 65, etc.).
11a) The image display screen has a screen for setting the hue or tone curve of the image (FIG. 65, etc.).

12). As a means for analyzing the signal, it has a screen for setting an average value of an arbitrary time interval or a moving average of an arbitrary number of periods (FIG. 49, etc.).
12a) As a means for analyzing a signal, a screen for selecting a statistical analysis method represented by t-test using signal fluctuation as a variable is provided (FIG. 49, etc.).

  According to the embodiment of the present invention, even an unskilled operator can easily obtain reliable data by a quick operation with few errors.

The block diagram which shows the structure of the principal part of the Example of the optical measuring device with which this invention is applied. FIG. 2 is a flow diagram as an example based on the present invention, in which a subject is measured using the optical measurement apparatus shown in FIG. 1. The figure which shows the initial screen displayed on a display part. The figure which shows the condition input screen displayed on a display part. The figure which shows the display screen during gain adjustment displayed on a display part. The figure which shows the measurement position display screen shown on a display part. The figure which shows the abnormality display screen displayed on a display part. The figure which shows the file creation screen displayed on a display part. The figure which shows the directory creation screen displayed on a display part. The figure which shows the measurement screen shown on a display part. The figure which shows the submenu screen of Info of FIG. 10 displayed on a display part. The figure which shows the measurement condition displayed on a display, and the input screen of a display condition. The figure which shows the submenu screen of Option of FIG. 10 displayed on a display part. The figure which shows the measurement data time series display screen displayed on a display part. The figure which shows the display condition input screen of the graph of FIG. 14 displayed on a display part. The figure which shows the file backup condition input screen displayed on a display part. The figure which shows the input setting screen of the other measurement apparatus output signal displayed on a display part. The figure which shows the rectangular wave output signal setting screen displayed on a display part. FIG. 19 is a diagram showing a rectangular wave output signal waveform whose conditions are set in FIG. 18. The figure which shows the external input trigger-synchronous measurement condition setting screen displayed on a display part. The figure which shows the measurement data acquisition condition setting screen displayed on a display part. The figure which shows the measurement signal confirmation screen displayed on a display part. The block diagram which shows the structure in the optical module of FIG. The figure which shows the example of geometric arrangement | positioning of an irradiation position and a detection position on the subject surface. The block diagram which shows the structure of the lock-in amplifier module of FIG. The graph as an example showing the time-dependent change of the measurement signal in a certain detection position, and the prediction no load signal calculated | required from this measurement signal. The graph as an example showing the time change of the relative variation | change_quantity of the density | concentration of oxidation and reduction | restoration hemoglobin in a certain measurement position. The figure which shows the contour image (topography image) produced from the time change of the relative variation | change_quantity of the oxyhemoglobin density | concentration of each measurement point by making the exercise | movement of a subject's left finger into a load. The figure which shows the contour-line image (topography image) created from the time change of the relative variation | change_quantity of the oxyhemoglobin density | concentration of each measurement point by making the exercise | movement of a subject's right finger into a load. The figure which shows the example of a display which overlapped the topography image with the brain surface image of a subject. FIG. 2 is a flow chart as an example based on the present invention, in which data analysis is performed after subject measurement processing is performed using the optical measurement device shown in FIG. 1. The figure which shows the process selection screen displayed on a display part. The figure which shows the analysis mode selection screen displayed on a display part. The figure which shows the file reading screen displayed on a display part. The figure which shows the mark edit screen displayed on a display part. The figure which shows the mark edit auxiliary | assistance screen displayed on a display part. The figure which shows the File menu screen of FIG. The figure which shows the Edit menu screen of FIG. The figure which shows the Option menu screen of FIG. The figure which shows the file preservation | save screen displayed on a display part. The figure which shows the graph display adjustment screen for mark edit displayed on a display part. The figure which shows the measurement condition display input screen displayed on a display part. The figure which shows the processing time definition screen for addition average analysis displayed on a display part. The figure which shows the molecular extinction coefficient display screen displayed on a display part. The figure which shows the fitting curve order setting screen displayed on a display part. The figure which shows the process file addition setting screen displayed on a display part. The figure which shows the image creation confirmation screen displayed on a display part. The figure which shows the processing time definition screen for non-addition average analysis displayed on a display part. The figure which shows the topograph condition setting screen displayed on a display part. The figure which shows the topograph condition setting screen displayed on a display part. The figure which shows the topographic image creation light irradiation and detection position setting screen displayed on a display part. The figure which shows the measurement position setting screen for topographic image creation displayed on a display part. The figure which shows the edit and display screen for topographic image creation displayed on a display part. The figure which shows the File menu screen of FIG. The figure which shows the Edit menu screen of FIG. The figure which shows the Option menu screen of FIG. The figure which shows the creation screen condition setting tab screen of the lower left part of FIG. The figure which shows the display image kind selection tab screen of the lower left part of FIG. The figure which shows the edit for 2 screen topography image creation displayed on a display part, and a display screen. The figure which shows the creation image kind setting screen displayed on a display part. The figure which shows the topography image reading screen displayed on a display part. The figure which shows the topography image reading screen displayed on a display part. The figure which shows the topography image preservation | save screen displayed on a display part. The figure which shows the topography image preservation | save screen displayed on a display part. The figure which shows the display color setting screen displayed on a display part. The figure which shows the analysis condition display screen displayed on a display part. The figure which shows the measurement file condition display screen displayed on a display part. The figure which shows the topography image creation condition screen displayed on a display part. The flow chart as an example based on this invention which displays required data after performing the measurement process and data analysis process of a test object using the optical measuring device shown in FIG. The figure which shows the graph menu screen displayed on a display part. The figure which shows the display graph selection screen displayed on a display part. The figure which shows the display graph selection screen displayed on a display part. The figure which shows the measurement data graph display screen displayed on a display part. The figure which shows the Option menu screen displayed on a display part. The figure which shows the fitting graph display condition setting screen displayed on a display part. The figure which shows the measurement mode setting screen displayed on a display part. The figure which shows the measurement channel position edit screen displayed on a display part. The figure which shows the measurement channel position edit screen in case a measurement surface is displayed on a display part. The figure which shows a measurement channel position edit screen in case a measurement surface is displayed on a display part. The figure which shows the File menu screen displayed on a display surface. The figure which shows the wavelength input glasses displayed on a display surface. The figure which shows the file reading screen displayed on a display part. The figure which shows the file preservation | save screen displayed on a display part. The figure which shows the fitting graph display screen displayed on a display part. The figure which shows the Edit menu screen displayed on a display part. The figure which shows the Option menu screen displayed on a display part. The figure which shows the fitting graph mapping display screen displayed on a display part. The figure which shows the hemoglobin graph display condition setting screen displayed on a display part. The figure which shows the hemoglobin graph display condition setting screen displayed on a display part. The figure which shows the hemoglobin density | concentration graph display screen displayed on a display part. The figure which shows the hemoglobin density | concentration graph mapping display screen displayed on a display part. The figure which shows the measurement flow as an example based on this invention in the case of measuring a specimen using the optical measuring device of FIG. The figure which shows the display screen during measurement displayed on a display part. The figure which shows the analysis flow as an example based on this invention in the case of performing the data analysis after a measurement process using the optical measuring device of FIG. The figure which shows the display flow as an example based on this invention for performing the display after data analysis using the optical measuring device of FIG. The figure which shows the graph presentation screen displayed on a display part.

Explanation of symbols

  DESCRIPTION OF SYMBOLS 1: Light source part, 2: Optical module, 3: Oscillation part, 8-1 to 8-4: Optical fiber for irradiation, 9: Subject, 10-1 to 105: Optical fiber for detection, 11-1 11-5: Photo diode, 12: Lock-in amplifier module, 16: Sample hold circuit module, 17: Switch (multiplexer), 18: Analog / digital converter, 19: Computer, 20: Storage device, 21: display unit, 22: operation unit.

Claims (5)

A plurality of light irradiation means for irradiating the subject with light;
A plurality of light receiving means for receiving light irradiated from the light irradiation means and propagated through the subject; and
The plurality of light irradiating means and the plurality of light receiving means are alternately arranged in a grid, and when the measurement point is a substantially midpoint between the light irradiating means and the light receiving means, the measurement points are arranged in a grid. And
A screen for setting the measurement point; and a display unit for displaying a metabolite concentration inside the subject.
The display unit displays a pair of information on the change in diameter of the metabolite concentration of the sample at the measurement point corresponding to the position of the measurement point and a screen for setting the measurement point. A biological light measuring device for measuring a concentration of a metabolite inside the subject.   The biological light measurement apparatus according to claim 1, wherein the light irradiation unit and the light receiving unit are arranged in a square lattice shape.   The living body light measuring apparatus according to claim 1, wherein the head inside the subject is measured.   The biological light measurement apparatus according to claim 1, wherein the display unit displays a setting screen for setting a display form of information on changes in diameter of metabolite concentration of the subject over time.   The display unit is configured to be able to display the setting screen, information on changes in metabolite concentration of the subject over time, and a screen for setting the measurement point on the same screen. 4. The biological light measurement device according to 4.

Images