JP2001346780A - Light measuring device for living body - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a light measuring device for living body suitable for obtaining information to get to know effect of anesthesia based on hemoglobin thickness in blood, and displaying it to be referred to for utilization of operation support. SOLUTION: Light of amplitude-modulated wavelength from a semiconductor laser controlled by a light module of a light source part is applied to a subject by means of an irradiation fiber, a living body passing light intensity signal taken from the subject through a detection fiber to be converted by a photo diode into an electric signal, and taken for each irradiation part modulation frequency by a lock-in amplifier module is A/D converted by an A/D converting part, it is stored in a recording part, and relative change quantity of concentration of hemoglobin is determined along a time axis in a processing part. In this processing part, deepness of anesthesia is calculated in a calculation method selected by a user, and a hemoglobin concentration image determined based on this value, and a reference image and an image object to calculation, or the image object to calculation only is displayed in a display part in an input/ output part.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a biological light measurement device that measures transmitted light, reflected light or scattering from a living body to measure biological information such as a change in blood hemoglobin concentration.
In particular, the present invention relates to a biological light measurement device suitable for acquiring information for knowing the effect of anesthesia from the measured hemoglobin concentration.

[0002]

2. Description of the Related Art Conventionally, the effects of anesthesia have been presumed from situations in which a patient does not move, there are no various reflexes, the heart rate and blood pressure are stable, and sweating is suppressed.

[0003]

In the above-mentioned conventional method, it is not possible to sufficiently grasp the degree of anesthesia being effective. Therefore, the effect of the anesthesia is insufficient and the patient is likely to awake during the operation, or an excessive amount of anesthetic is used. The administration took time to recover after surgery and sometimes required nursing. For this reason, a device capable of confirming a necessary and sufficient anesthetic effect for surgery has been desired. Therefore, an object of the present invention is to provide a biological light measurement device suitable for acquiring information for knowing an anesthetic effect from hemoglobin concentration in blood, displaying the acquired information, and referencing the information for use in assisting surgery. Is to do.

[0004]

When an anesthetic is administered to a patient, the hemoglobin concentration in the blood changes as a response to the stimulus. Focusing on this point, the above object of the present invention is achieved by the following means.

(1) A light irradiating means for irradiating a living body with light modulated differently from a plurality of light irradiating positions, and light transmitted through the living body is detected at a plurality of detecting positions, and the light irradiating position is determined. For a plurality of measurement sites determined by the relationship, a light detection unit that outputs an electric signal corresponding to the detected light amount, and a signal processing unit that calculates the hemoglobin concentration for each of the measurement sites based on the electric signal from the light detection unit, A biological light measuring device comprising means for displaying the calculation result of the signal processing means, wherein the hemoglobin concentration before and during anesthesia is calculated by the signal processing means, and the calculation results and the pre-anesthesia and anesthesia based on the calculation result are calculated. The lapse of time of the hemoglobin concentration is simultaneously displayed on the display means.

(2) A light irradiating means for irradiating the living body with light having different modulations from a plurality of light irradiating positions, and detecting a light transmitted through the living body at a plurality of detecting positions to determine a light irradiating position. For a plurality of measurement sites determined by the relationship, a light detection unit that outputs an electric signal corresponding to the detected light amount, and a signal processing unit that calculates the hemoglobin concentration for each of the measurement sites based on the electric signal from the light detection unit, A biological light measurement device comprising: a means for displaying a calculation result of the signal processing means; and an anesthesia depth calculation means for providing an index of an anesthetic effect in the signal processing means, and an anesthesia depth value obtained by the anesthesia depth calculation means. Is displayed on the display means.

(3) Light irradiation means for irradiating a living body with light modulated differently from a plurality of light irradiation positions, and light transmitted through the living body is detected at a plurality of detection positions. For a plurality of measurement sites determined by the relationship, a light detection unit that outputs an electric signal corresponding to the detected light amount, and a signal processing unit that calculates the hemoglobin concentration for each of the measurement sites based on the electric signal from the light detection unit, In a living body optical measurement device comprising means for displaying the calculation result of the signal processing means, the hemoglobin concentration before and during anesthesia is calculated by the signal processing means, and based on the calculation results, before and during the anesthesia. And the anesthesia depth value obtained by the anesthesia depth calculation means indicating the anesthesia effect index provided in the signal processing means are simultaneously displayed on the display means.

(4) A light irradiating means for irradiating the living body with light modulated differently from a plurality of light irradiating positions, and light transmitted through the living body is detected at a plurality of detecting positions, and For a plurality of measurement sites determined by the relationship, a light detection unit that outputs an electric signal corresponding to the detected light amount, and a signal processing unit that calculates the hemoglobin concentration for each of the measurement sites based on the electric signal from the light detection unit, And a means for displaying a calculation result of the signal processing means.In the biological light measurement apparatus, an index value of an anesthesia depth corresponding to each stage after anesthesia in the signal processing means using a hemoglobin concentration change amount corresponding to a stimulus. Is provided, and an index value of the anesthesia depth calculated by the anesthesia depth calculation means is displayed on the display means.

[0009]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, the present invention will be described in detail with reference to the drawings together with embodiments of the present invention. In all the drawings for describing the embodiments of the present invention, components having the same functions are denoted by the same reference numerals, and their repeated description will be omitted.

FIG. 1 is a diagram for explaining a schematic configuration of a living body light measuring device according to a first embodiment of the present invention.
Is an optical module, 3 is a semiconductor laser, 8 is an irradiation optical fiber, 9 is an object, 10 is a detection optical fiber, 11 is a photodiode, 12 is a lock-in amplifier module, and 16 is an A / D.
A converter, 17 is a control unit, 18 is a recording unit, 19 is a processing unit, and 20 is an input / output unit. However, other configurations except for the processing of the measured values in the processing unit 19 use well-known means and mechanisms disclosed in Japanese Patent Application Laid-Open No. 9-149903.

[0011] The living body light measuring device is, for example, a subject 9
It irradiates light from the skin surface of the head and images the inside of the cerebrum from the passing light detected on the skin surface of the head. Here, the number of measurement channels, that is, the measurement position (measurement channel) is 24 The case will be described. Of course, the present invention is applicable not only to the head but also to other parts as the measurement object, and to a living body other than a human body or a living body.
Further, by further increasing the number of light irradiation positions and light detection positions, the number of measurement channels can be increased, and the measurement area can be enlarged.

In FIG. 1, a light source unit 1 includes eight optical modules 2. Each optical module 2 has a plurality of wavelengths in the visible to infrared wavelength range, for example, 780 nm and 830 nm.
Two semiconductor lasers 3 each emitting two wavelengths of nm3
It is composed of These two wavelengths of light are 780nm and 830nm
However, the present invention is not limited to this. For the light source unit 1, a light emitting diode may be used instead of the semiconductor laser 3. All 16 semiconductor lasers included in this light source 1
Frequency modulation and amplitude modulation are performed by the current. Although this modulation is performed in analog, digital modulation may be used. The optical module 2 includes an optical fiber coupler (not shown) for introducing 780 nm and 830 nm light emitted from the respective semiconductor lasers into one optical fiber (irradiation optical fiber 8).

Accordingly, the mixed light of the two wavelengths emitted from the light source unit 1 is applied to the head of the subject 9 to be measured from the tips of the eight irradiation optical fibers 8 connected to each optical module 2. Is irradiated.

At this time, each irradiation optical fiber 8 is fixed to a measurement probe (not shown), and irradiates light to different positions. However, in the present embodiment, the distal ends of the irradiation optical fibers 8 and the detection fibers 10 are alternately arranged on a square lattice. The intermediate point between the irradiation probe connected to the tip of the irradiation fiber and the detection probe connected to the tip of the detection fiber is the measurement position. The details of the measurement probe are described in JP-A-9-149903.

Light that has passed through the head, ie, light that has passed through the living body, is condensed by eight detection optical fibers 10 fixed to a measurement probe unit (not shown).
, A photodetector connected to the other end of the photodiode 11
Is detected by As the photodiode 11, a well-known avalanche photodiode capable of measuring light with high sensitivity is desirable. Further, as the photodetector, any other photoelectric conversion element such as a photomultiplier tube may be used. After the light passing through the living body is converted into an electric signal (light intensity signal passing through the living body) by the photodiodes 11, the light is passed through a lock-in amplifier module 12 composed of a plurality of lock-in amplifiers. The modulation signal corresponding to the irradiation position and the wavelength is selectively detected.

At this time, the lock-in amplifier module 12
The modulated signals output from the optical discs are separated into light intensity signals passing through the living body corresponding to the wavelength and the irradiation position. However, in the embodiment of FIG.
Since measurement is performed at 24 measurement positions, the number of signals to be measured is
It will be 48. Therefore, the lock-in amplifier module 12 of the first embodiment uses a total of 48 lock-in amplifiers (not shown). However, when digital modulation is used, a digital filter or a digital signal processor is used for detecting a modulation signal.

The biological-passing light intensity signal analog-outputted from the lock-in amplifier module 12 is a 48-channel A / A
Each signal is converted into a digital signal by a D converter (analog-digital converter) 16. Each digital signal is a biological passing light intensity signal for each wavelength and irradiation position. These measurements are controlled by the control unit 17. The living body passing light intensity signal converted into the digital signal is recorded in the recording unit 18.

The living body passing light intensity signal recorded in the recording unit 18 in real time by the processing unit 19 is displayed on the input / output unit 20 on the monitor. Further, the processing unit 19 calculates a change in oxygenated hemoglobin concentration, a change in deoxygenated hemoglobin concentration, and a change in total hemoglobin concentration from the biological-passing light intensity signal, and displays them on the display device of the input / output unit 20 in a time course or as a topographic image. I do.

A method of calculating a change in oxygenated hemoglobin and deoxygenated hemoglobin concentration and a total amount of hemoglobin concentration from a light intensity signal passing through a living body at each detection position and displaying the calculated amount in a time course or topography is disclosed in Reference 1.
(JP-A-9-98972) and Document 2 (JP-A-9-14999)
No. 03 gazette), so a detailed description is omitted. The processing unit calculates the anesthesia depth value that quantitatively expresses the anesthetic effect
The input and output of various parameters necessary for the calculation and the output of the calculation result are performed by the input / output unit 20.

Hereinafter, the hemoglobin image includes not only a topography but also a time course, and a method of obtaining a depth of anesthesia will be described.

<< Method for Obtaining Based on Measured Image Data Before Anesthesia >> The comparison and calculation of the depth of anesthesia will be described with reference to the flowchart for explaining the procedure of FIG. 4 and the block diagram of FIG. 2 and 3 are explanatory diagrams of a screen for comparing and examining the depth of anesthesia. Hereinafter, description will be given according to the flowchart of FIG.

(Step 401) The measurement image stored in the storage area of the measurement image data storage unit 501 of FIG. 5 in the recording unit 18 of FIG. 1 is displayed on the screen of the display device of the input / output unit 20 of FIG. The data or hemoglobin data is displayed, and the user designates a reference image before anesthesia from the input / output unit 20 in FIG. If there is no reference image, a reference image stored in an external storage device (not shown) such as a magneto-optical disk is input via the input / output unit. If there is no reference image already taken, the process proceeds to step 402. If there is a photographed image and the reference image can be input without photographing, the process proceeds to step 403. Figure 2 shows the input of parameters required for calculation
Alternatively, it is performed via the operation unit on the display screen of FIG. 3 (input means for parameters is not shown). This parameter is described below.

(A) Grade (Grade); (B) Grade (GO) before anesthesia; “0” or “1” (C) Calculation target channel (ch): whether to use all channels or a channel predetermined according to the stimulus,
Whether the channel is specified individually by the user.

(Step 402) A light,
A stimulus such as a sound is loaded, and a reference image required for calculating the anesthesia depth value is photographed, designated as a reference image, and stored in the measurement image storage unit 501 provided in the recording unit in FIG.

(Step 403) If the designated reference image is not a hemoglobin image, it is converted into a hemoglobin image by the hemoglobin (Hb) calculation means 502 in FIG.
The reference image in FIG. 5 is stored in the calculation target image storage unit 503. These are provided in the processing unit 19. Hb calculation means 50
2 is the above document 1 (JP-A-9-98972) and document 2
A known means described in JP-A-9-149903 is used.

(Step 404) As in step 401, the measured image data (the same stimulus and
The user specifies the measurement data of the photographing condition. If it is on an external storage medium, input from this medium and go to step 406
Proceed to. If not, proceed to step 405.

(Step 405) Data of the patient under anesthesia is collected under the same stimulus and imaging conditions as the reference image.

(Step 406) A hemoglobin image of the designated anesthesia depth calculation target image is obtained in the same manner as in step 403, and is stored in the storage unit of the reference image and calculation target image 503 in FIG.

(Step 407) As shown in FIG. 2, the reference image and the comparison target image are arranged side by side and displayed on the display unit.
FIG. 2A shows a load period of a task (for example, light stimulation). Numerals 1 to 24 in FIG. 2 indicate measurement channel numbers,
The measurement period is a range indicated by an arrow in the case of two channels. The same applies to other channels. The scale of the left and right images (for example, the change in the concentration of hemoglobin (Hb) shown in FIG. 2B, mM · mm (the product of the millimolar concentration of Hb in blood multiplied by the optical path length) is the same. The images of hemoglobin may be superimposed and displayed for each measurement channel as shown in (a) of Fig. 3. These images before and during anesthesia can be compared to confirm the anesthetic effect.

(Step 408) If the parameters of the anesthesia depth calculation have already been input, they are displayed as shown in FIG. 2 (c) or FIG. 3 (b), and if the values are satisfactory, the flow proceeds to step 410. . Otherwise, go to step 409. The entered parameters are to be saved.

(Step 409) The user is caused to select and input the parameters (a), (b), and (c) described in step 401 through FIG. 2 (c) or FIG. 3 (b).
When a channel corresponding to the stimulus is selected as the calculation target channel (ch), the type of the stimulus is input, and the channel corresponding to the input stimulus type is set to 506 in FIG.
From the channel selection section according to the stimulus. Figure 5
The channel selection unit according to the 506 stimuli is the processing unit in FIG.
It should be created in advance in the anesthesia depth calculation area provided in 19.

(Step 410) The number (N) of channels to be calculated is calculated, and data of a task section corresponding to the channel to be calculated of the reference image and the target image is extracted as a pre-process of calculation. To save.
The data of the task section is data of the hemoglobin concentration at the time of the task load, as shown in FIG.

(Step 411) The anesthesia depth value is calculated.
There are four types of calculation formulas for this calculation, and any calculation formula may be used, and the operator can specify which calculation formula is to be used by inputting from the input / output unit 20 in FIG. Hereinafter, these are described. In these formulas, the ch of the reference image is used.
X (i, j) is the value of each point in (i), and ch (i) of the image to be calculated
Is Z (i, j). Here, j is the number of sampling points between tasks after the integration process, and 1, 2, ...
... M

(1) Calculation method 1 The correlation coefficient R (i) for each corresponding channel is given by the following equation (1).

(Equation 1) From this R (i), the anesthesia depth G can be obtained from equation (2).

[0035]

(Equation 2) (2) Calculation method 2 Assuming that the ratio of the integrated value for each corresponding channel is R (i), from equation (3),

(Equation 3) From this R (i), the anesthesia depth G can be obtained from equation (2).

(3) Calculation method 3 From the maximum value of the corresponding channel, R (i) is calculated as in equation (4).

(Equation 4) From this R (i), the depth of anesthesia G is obtained from equation (2).

(4) Calculation method 4 The maximum value of the corresponding channel is 1 / n of the maximum value of the reference image.
From the equation (5), assuming the number of channels as R (i),

(Equation 5) From this R (i), the anesthesia depth G can be obtained from equation (2). It should be noted that, in the expressions (2) and (5), if there is no particular input, underlining is performed as a default.

(Step 412) The depth of anesthesia obtained by the above formula is displayed on the operation unit shown in FIG. 2 (c) or FIG. 3 (b).

In the above embodiment, the depth of anesthesia is calculated using data of only the task section. However, a section delayed from the task section or all sections may be employed. Further, in the above-described embodiment, among hemoglobins, oxygenated hemoglobin has been described, but the present invention is not limited to this, and total hemoglobin and deoxygenated hemoglobin may be used.

<< Method of Calculating Depth of Anesthesia Without Reference to Data Before Anesthesia >> The data before anesthesia immediately before surgery is highly swaying in some patients, and it is inappropriate to use this as a reference for calculating the depth of anesthesia. There are cases. In such a case, there is a method of calculating the anesthesia depth value for each stage of anesthesia without using the data before anesthesia as a reference in calculating the depth of anesthesia. Hereinafter, an embodiment using this method will be described with reference to the flowchart of FIG. 6 and the configuration diagram of FIG. In this embodiment, the depth value of anesthesia is calculated for each stage of anesthesia without using the data before anesthesia as a reference.

The calculation target image of the calculation target image data storage unit 701 in FIG. 7 is stored in the recording unit 18 in FIG. 1, and the anesthesia depth calculation means 702 in FIG.
The calculation result storage unit is provided with an anesthesia depth calculation area in advance in the processing unit 19 of FIG. 1 and is placed there. Hereinafter, description will be given according to the flowchart of FIG.

(Step 601) The calculation target hemoglobin image in the recording unit 18 in FIG. 1 is displayed on the screen of the display device of the input / output unit 20 in FIG. 1, and the calculation target site (channel) is set. As a setting method, in the present embodiment, a stimulus type is input, and a channel corresponding to the input stimulus type is plotted.
Withdraw from the 703 table at 7. The method of setting the calculation target part is not limited to this method, and the channel number may be directly input, or may be specified on the screen by a mouse or the like. As a setting content, when a 4 × 4 probe is attached around the outer occipital ridge and light stimulation is used, the entire 4 × 4 area may be set as a calculation target.

(Step 602) A section to be calculated is set. The biological optical measurement device of the present embodiment captures the response of the blood flow, and the blood flow responds to the stimulus with a delay, so that a stimulus section is usually delayed by about 6 seconds. As setting method,
Specify the time (seconds) from the start of stimulation as a reference. If it is desired to include the section before the stimulus as a calculation target, it may be specified as (−2, 10). This means that a section from 2 seconds before the start of the stimulus to 10 seconds after the start of the stimulus is to be calculated. When the response is long and leaves a tail as in the case of light stimulation, the entire section may be set as the calculation target section.

(Step 603) A signal for selecting a calculation method is input from the input / output unit 20 in FIG. 1 and the anesthesia depth calculation method to be calculated in step 605 is selected. Even in the same facility, different calculation methods may be selected depending on the stimulus, measurement site, medicine, and the like to be used.

(Step 604) If there are necessary parameters in accordance with the selected calculation method, they are input. If the parameters of the anesthesia depth calculation have already been input, they are displayed, and if the values are satisfactory, the process proceeds to the next step. Otherwise,
Enter here. Here, the parameter refers to step 60
X0 in the calculation method (2) shown in FIG.

(Step 605) The anesthesia depth is calculated by the selected method. This calculation includes the following three calculation methods. As calculation pre-processing, data of a calculation target channel and a calculation target section of the calculation target channel are extracted.
For the extracted data, the number of calculation target channels (N) and the number of data in the calculation target section M are calculated, and the hemoglobin value of each point for each channel ch (i) (i = 1, 2,..., N) Is defined as X (i, j) (j = 1, 2,..., M) and the depth of anesthesia is defined as G, and the following calculation is performed.

(1) Calculation method 1 For each calculation target channel (region), the maximum value of the change in cerebral blood flow in the calculation target section due to the stimulus is calculated, and the average value of all the changes is calculated. .
The stimulus response results in an increase or decrease in cerebral blood flow, and the maximum value of the change is considered to indicate the intensity of the response. Taking the average value has the meaning of leveling the reaction strength of the site to be reacted. From this, the anesthesia depth G is given by

(Equation 6) , Which is in units of mM · mm and represents the average of the approximate maximum change in cerebral blood flow.

FIG. 8 shows the results of calculation of G in equation (6) for three patients, which were performed under shallow anesthesia (2 μg / ml) and normal anesthesia (4 μg / ml).
g / ml) and deep anesthesia (6 μg / ml). It can be seen that the depth G of anesthesia decreases as the depth of anesthesia increases. As a result, it is understood that when the anesthesia depth value G becomes 0.02 mM · mm or less, the anesthesia is moderately or more.

(2) Calculation method 2 The ratio of the maximum value of the absolute value of the change in the cerebral blood flow to the channel to be calculated of the channel (region) having a certain value (X0) or more is calculated. In the case of, the ratio of the area that actually reacts to a certain amount or more in the calculation target area is shown. From this, the depth of anesthesia is given by equations (7) and (8).

(Equation 7) And there is no unit. The user inputs the constant value (X0).

FIG. 9 shows data calculated for three patients assuming that X0 = 0.014 (mM · mm) (a value excluding the effect of positive pressure breathing).
l) with a value of 0.55-0.9, and deep anesthesia (6 μg / ml) with a value of 0.1-0.3
It can be seen that this value is an index of the depth of anesthesia.

(3) Calculation method 3 The sum of the absolute values of changes in blood flow in the calculation target section of the calculation target channel is calculated and divided by the total number of calculation target channels to obtain the average of the integral value for each calculation target channel. It is. From this, the depth of anesthesia from equation (9)

(Equation 8) And the unit is mM · mm. Represents the magnitude of the overall response to the stimulus. Again, as the depth of anesthesia increases,
Since the magnitude of the reaction is reduced, it can be said that it is an indicator of the depth of anesthesia.

(Step 606) The calculated anesthesia depth value is displayed on the input / output unit 20 together with the hemoglobin image. In the above embodiment, oxygenated hemoglobin among hemoglobins has been described, but the present invention is not limited to this, and total hemoglobin and deoxygenated hemoglobin may be used.

As described above, according to the present invention, the hemoglobin concentrations before and during anesthesia are calculated, and based on the calculation results, the time courses of the hemoglobin concentrations before and during anesthesia are simultaneously displayed, or The anesthesia depth value representing the effect was obtained by calculation without reference to the data of the patient before anesthesia, and this was displayed simultaneously with the hemoglobin concentration image. Thus, it is possible to provide a living body optical measurement device that can be quantitatively grasped and is suitable for confirming the anesthetic effect when performing an operation under anesthesia.

[Brief description of the drawings]

FIG. 1 is a diagram for explaining a schematic configuration of a biological light measurement device of the present invention.

FIG. 2 is a diagram showing the time course of hemoglobin concentration before and during anesthesia side by side.

FIG. 3 is a diagram showing the time course of hemoglobin concentration before and during anesthesia in an overlapping manner.

FIG. 4 is a flowchart for calculating a depth of anesthesia based on measured image data before anesthesia according to the present invention.

FIG. 5 is a configuration diagram of an anesthesia depth calculator in FIG. 4;

FIG. 6 is a flowchart for calculating a value of anesthesia depth not based on data before anesthesia according to the present invention.

FIG. 7 is a configuration diagram of an anesthesia depth calculator in FIG. 6;

FIG. 8 is a calculation example of the anesthesia depth calculated by the calculation formula of Expression (6).

FIG. 9 is a calculation example of the anesthesia depth calculated by the calculation formulas (7) and (8).

[Explanation of symbols]

1 light source unit, 2 optical module, 3 semiconductor laser 3,
8 irradiation optical fiber, 9 subject, 10 detection optical fiber, 11 photodiode, 12 lock-in amplifier module, 16 A / D converter, 17 control unit,
18 recording unit, 19 processing unit, 20 input / output unit, 501
Measurement image data storage unit, 502 Hb calculation unit, 503
Reference image, calculation target image storage unit, 504 depth of anesthesia calculation means, 506 channel selection unit according to stimulus, 5
05 calculation result storage unit, 701 calculation target image data storage unit, 702 anesthesia depth calculation means, 703 channel selection unit according to stimulus, 704 calculation result storage unit

 ──────────────────────────────────────────────────続 き Continued on the front page F term (reference) 2G059 AA05 BB12 CC18 EE02 FF01 GG01 GG02 GG03 GG09 HH01 HH02 JJ17 MM09 PP04 4C038 KK00 KL05 KL07

Claims (4)

[Claims] 1. A light irradiating means for irradiating a living body with light modulated differently from a plurality of light irradiating positions, and a relationship between the light irradiating positions by detecting light transmitted through the living body at a plurality of detecting positions. For a plurality of measurement sites determined by, a light detection unit that outputs an electric signal corresponding to the detected light amount, a signal processing unit that calculates the hemoglobin concentration of each measurement site based on the electric signal from the light detection unit, In a living body optical measurement device comprising means for displaying the calculation result of the signal processing means, the hemoglobin concentration before and during anesthesia is calculated by the signal processing means, and based on the calculation results, before and during the anesthesia. A biological light measuring apparatus, wherein the time course of the hemoglobin concentration is simultaneously displayed on the display means. 2. A relationship between light irradiation means for irradiating a living body with light modulated differently from a plurality of light irradiation positions, and light transmitted through the living body at a plurality of detection positions, and a relationship with the light irradiation position. For a plurality of measurement sites determined by, a light detection unit that outputs an electric signal corresponding to the detected light amount, a signal processing unit that calculates the hemoglobin concentration of each measurement site based on the electric signal from the light detection unit, And a means for displaying a calculation result of the signal processing means.In the biological light measurement device, an anesthesia depth calculation means for indicating an index of an anesthetic effect is provided in the signal processing means, and the anesthesia depth value obtained by the anesthesia depth calculation means is calculated. A biological light measurement device characterized by displaying on the display means. 3. A relationship between light irradiation means for irradiating a living body with light modulated differently from a plurality of light irradiation positions, and light transmitted through the living body at a plurality of detection positions, and a relationship with the light irradiation position. For a plurality of measurement sites determined by, a light detection unit that outputs an electric signal corresponding to the detected light amount, a signal processing unit that calculates the hemoglobin concentration of each measurement site based on the electric signal from the light detection unit, In a biological optical measurement device comprising means for displaying the calculation result of the signal processing means, the hemoglobin concentration before and during anesthesia is calculated by the signal processing means, and based on the calculation result, the hemoglobin concentration before and during the anesthesia is calculated. A living body characterized in that a time course of hemoglobin concentration and an anesthesia depth value obtained by an anesthesia depth calculation means indicating an anesthesia effect index provided in the signal processing means are simultaneously displayed on the display means. Optical measuring device. 4. A relationship between a light irradiation means for irradiating a living body with light modulated differently from a plurality of light irradiation positions and light transmitted through the living body at a plurality of detection positions, and a relationship with the light irradiation position. For a plurality of measurement sites determined by, a light detection unit that outputs an electric signal corresponding to the detected light amount, a signal processing unit that calculates the hemoglobin concentration of each measurement site based on the electric signal from the light detection unit, In a biological light measurement device comprising means for displaying a calculation result of the signal processing means, an index value of an anesthesia depth corresponding to each stage after anesthesia in the signal processing means using a hemoglobin concentration change amount corresponding to the stimulus. A biological light measurement device, comprising: an anesthetic depth calculating means for calculating; and an index value of the anesthetic depth obtained by the anesthetic depth calculating means is displayed on the display means.