JP4472541B2

JP4472541B2 - エステル化合物及びその医薬用途

エステル化合物及びその医薬用途 Download PDF

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Publication number: JP4472541B2
Authority: JP; Japan
Prior art keywords: phenyl; biphenyl; carbonyl; amino; trifluoromethyl
Prior art date: 2002-02-28
Legal status : Expired - Lifetime

Application number

JP2005020179A

Other languages

English (en)

Japanese (ja)

Other versions

JP2005220133A (ja

JP2005220133A5 (enExample

Inventor

篤萩原

泰弘大江

直也小谷

静枝渡辺

拓池ノ上

孝河合

研也眞殿

寿生谷口

Current Assignee

Japan Tobacco Inc

Original Assignee

Japan Tobacco Inc

Priority date

2002-02-28

Filing date

2005-01-27

Publication date

2010-06-02

2005-01-27 Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc

2005-01-27 Priority to JP2005020179A priority Critical patent/JP4472541B2/ja

2005-08-18 Publication of JP2005220133A publication Critical patent/JP2005220133A/ja

2008-09-25 Publication of JP2005220133A5 publication Critical patent/JP2005220133A5/ja

2010-06-02 Application granted granted Critical

2010-06-02 Publication of JP4472541B2 publication Critical patent/JP4472541B2/ja

2023-02-28 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

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-1 Ester compound Chemical class 0.000 title claims description 284
125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 119
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 84
150000003839 salts Chemical class 0.000 claims description 72
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 68
125000005843 halogen group Chemical group 0.000 claims description 63
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 39
125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 37
125000005915 C6-C14 aryl group Chemical group 0.000 claims description 36
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 32
125000000217 alkyl group Chemical group 0.000 claims description 30
125000001424 substituent group Chemical group 0.000 claims description 29
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims description 26
VGUWZCUCNQXGBU-UHFFFAOYSA-N 3-[(4-methylpiperazin-1-yl)methyl]-5-nitro-1h-indole Chemical compound C1CN(C)CCN1CC1=CNC2=CC=C([N+]([O-])=O)C=C12 VGUWZCUCNQXGBU-UHFFFAOYSA-N 0.000 claims description 25
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 21
125000002252 acyl group Chemical group 0.000 claims description 20
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 20
125000000623 heterocyclic group Chemical group 0.000 claims description 19
125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 18
125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 18
125000003710 aryl alkyl group Chemical group 0.000 claims description 17
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 16
229910052757 nitrogen Inorganic materials 0.000 claims description 16
125000004433 nitrogen atom Chemical group N* 0.000 claims description 15
125000004432 carbon atom Chemical group C* 0.000 claims description 14
PIGFYZPCRLYGLF-UHFFFAOYSA-N Aluminum nitride Chemical compound [Al]#N PIGFYZPCRLYGLF-UHFFFAOYSA-N 0.000 claims description 12
125000003545 alkoxy group Chemical group 0.000 claims description 11
125000002102 aryl alkyloxo group Chemical group 0.000 claims description 11
125000003277 amino group Chemical group 0.000 claims description 10
125000004093 cyano group Chemical group *C#N 0.000 claims description 10
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 9
125000005914 C6-C14 aryloxy group Chemical group 0.000 claims description 8
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 8
IHJDXXYPXNHHIX-UHFFFAOYSA-N diethyl 2-benzyl-2-[[2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1CC(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 IHJDXXYPXNHHIX-UHFFFAOYSA-N 0.000 claims description 7
CGQWKGASBJMXHM-UHFFFAOYSA-N (1-phenylcyclopentyl)methyl 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=C(NC(=O)C=2C(=CC=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(C(=O)N(C)C)=CC=1CC(=O)OCC1(C=2C=CC=CC=2)CCCC1 CGQWKGASBJMXHM-UHFFFAOYSA-N 0.000 claims description 5
GJRYCURWLNPQDI-UHFFFAOYSA-N (1-phenylcyclopropyl)methyl 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=C(NC(=O)C=2C(=CC=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(C(=O)N(C)C)=CC=1CC(=O)OCC1(C=2C=CC=CC=2)CC1 GJRYCURWLNPQDI-UHFFFAOYSA-N 0.000 claims description 5
HYIDKCDAAGHEOM-UHFFFAOYSA-N (2-acetamido-2-phenylethyl) 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=C(NC(=O)C=2C(=CC=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(C(=O)N(C)C)=CC=1CC(=O)OCC(NC(C)=O)C1=CC=CC=C1 HYIDKCDAAGHEOM-UHFFFAOYSA-N 0.000 claims description 5
NWTJZISLLRPHOQ-UHFFFAOYSA-N (2-ethyl-2-phenylbutyl) 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(CC)(CC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 NWTJZISLLRPHOQ-UHFFFAOYSA-N 0.000 claims description 5
125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims description 5
OVWBUWRCQMZQOV-UHFFFAOYSA-N 2,2-diphenylethyl 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=C(NC(=O)C=2C(=CC=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(C(=O)N(C)C)=CC=1CC(=O)OCC(C=1C=CC=CC=1)C1=CC=CC=C1 OVWBUWRCQMZQOV-UHFFFAOYSA-N 0.000 claims description 5
VOHAROSLRWMMRA-UHFFFAOYSA-N 2-[(2-phenylbenzoyl)amino]ethyl 4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzoate Chemical compound C1=CC(C(F)(F)F)=CC=C1C1=CC=CC=C1C(=O)NC1=CC=C(C(=O)OCCNC(=O)C=2C(=CC=CC=2)C=2C=CC=CC=2)C=C1 VOHAROSLRWMMRA-UHFFFAOYSA-N 0.000 claims description 5
QZJREBZTHNAMSE-UHFFFAOYSA-N 2-[8-(2,2,2-trifluoroethylcarbamoyl)naphthalen-1-yl]ethyl 4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzoate Chemical compound C=12C(C(=O)NCC(F)(F)F)=CC=CC2=CC=CC=1CCOC(=O)C(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 QZJREBZTHNAMSE-UHFFFAOYSA-N 0.000 claims description 5
VTSSCHXVHPNDFN-UHFFFAOYSA-N 2-[[2-(2-phenylphenyl)acetyl]amino]ethyl 4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzoate Chemical compound C1=CC(C(F)(F)F)=CC=C1C1=CC=CC=C1C(=O)NC1=CC=C(C(=O)OCCNC(=O)CC=2C(=CC=CC=2)C=2C=CC=CC=2)C=C1 VTSSCHXVHPNDFN-UHFFFAOYSA-N 0.000 claims description 5
BKKLNFHYKNFWHT-UHFFFAOYSA-N 3-[2-(2,2,2-trifluoroethylcarbamoyl)naphthalen-1-yl]propyl 4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzoate Chemical compound FC(F)(F)CNC(=O)C1=CC=C2C=CC=CC2=C1CCCOC(=O)C(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 BKKLNFHYKNFWHT-UHFFFAOYSA-N 0.000 claims description 5
WYSXDUDZIZCIDS-UHFFFAOYSA-N [2-(2,5-dioxopyrrolidin-1-yl)-2-phenylethyl] 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=C(NC(=O)C=2C(=CC=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(C(=O)N(C)C)=CC=1CC(=O)OCC(C=1C=CC=CC=1)N1C(=O)CCC1=O WYSXDUDZIZCIDS-UHFFFAOYSA-N 0.000 claims description 5
NDSMJXYABVYBBJ-UHFFFAOYSA-N [2-(butanoylamino)-2-phenylethyl] 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(NC(=O)CCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 NDSMJXYABVYBBJ-UHFFFAOYSA-N 0.000 claims description 5
MKRBVMUFKWAUOX-UHFFFAOYSA-N [2-(ethylcarbamoyl)phenyl]methyl 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound CCNC(=O)C1=CC=CC=C1COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 MKRBVMUFKWAUOX-UHFFFAOYSA-N 0.000 claims description 5
ORKNWIYWHTUVHK-UHFFFAOYSA-N [2-(methanesulfonamido)-2-phenylethyl] 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=C(NC(=O)C=2C(=CC=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(C(=O)N(C)C)=CC=1CC(=O)OCC(NS(C)(=O)=O)C1=CC=CC=C1 ORKNWIYWHTUVHK-UHFFFAOYSA-N 0.000 claims description 5
CHYOBTQXSFBZHG-UHFFFAOYSA-N [2-[2-(ethylamino)-2-oxoethyl]phenyl]methyl 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound CCNC(=O)CC1=CC=CC=C1COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 CHYOBTQXSFBZHG-UHFFFAOYSA-N 0.000 claims description 5
ZWFSLJZDLSOHKD-UHFFFAOYSA-N [2-[methyl(propanoyl)amino]-2-phenylethyl] 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(N(C)C(=O)CC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 ZWFSLJZDLSOHKD-UHFFFAOYSA-N 0.000 claims description 5
VJDWXCWQEQIFJZ-UHFFFAOYSA-N [3-(2,6-dichlorophenyl)-4-oxo-4-(2,2,2-trifluoroethylamino)butyl] 4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzoate Chemical compound ClC=1C=CC=C(Cl)C=1C(C(=O)NCC(F)(F)F)CCOC(=O)C(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 VJDWXCWQEQIFJZ-UHFFFAOYSA-N 0.000 claims description 5
BPLVAFMVFAJOGK-UHFFFAOYSA-N [3-(2-chlorophenyl)-4-oxo-4-(2,2,2-trifluoroethylamino)butyl] 4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzoate Chemical compound C=1C=CC=C(Cl)C=1C(C(=O)NCC(F)(F)F)CCOC(=O)C(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 BPLVAFMVFAJOGK-UHFFFAOYSA-N 0.000 claims description 5
IZIWDYQEDGCNHT-UHFFFAOYSA-N [3-(ethylamino)-3-oxo-2-phenylpropyl] 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 IZIWDYQEDGCNHT-UHFFFAOYSA-N 0.000 claims description 5
MOPZIIVTOPWMPR-UHFFFAOYSA-N [3-acetyloxy-2-(acetyloxymethyl)-2-phenylpropyl] 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=C(NC(=O)C=2C(=CC=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(C(=O)N(C)C)=CC=1CC(=O)OCC(COC(C)=O)(COC(C)=O)C1=CC=CC=C1 MOPZIIVTOPWMPR-UHFFFAOYSA-N 0.000 claims description 5
VCJSMQOVBIPWRL-UHFFFAOYSA-N [3-hydroxy-2-(hydroxymethyl)-2-phenylpropyl] 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=C(NC(=O)C=2C(=CC=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(C(=O)N(C)C)=CC=1CC(=O)OCC(CO)(CO)C1=CC=CC=C1 VCJSMQOVBIPWRL-UHFFFAOYSA-N 0.000 claims description 5
NMNZOMPKESKEMF-UHFFFAOYSA-N [3-naphthalen-1-yl-4-oxo-4-(2,2,2-trifluoroethylamino)butyl] 4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzoate Chemical compound C=1C=CC2=CC=CC=C2C=1C(C(=O)NCC(F)(F)F)CCOC(=O)C(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 NMNZOMPKESKEMF-UHFFFAOYSA-N 0.000 claims description 5
DOBZQVMLNFFOHW-UHFFFAOYSA-N [4-oxo-3,3-diphenyl-4-(2,2,2-trifluoroethylamino)butyl] 4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzoate Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(C(=O)NCC(F)(F)F)CCOC(=O)C(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 DOBZQVMLNFFOHW-UHFFFAOYSA-N 0.000 claims description 5
CXDWABBSQMGEJR-UHFFFAOYSA-N [4-oxo-3-(2-phenylphenyl)-4-(2,2,2-trifluoroethylamino)butyl] 4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzoate Chemical compound C=1C=CC=C(C=2C=CC=CC=2)C=1C(C(=O)NCC(F)(F)F)CCOC(=O)C(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 CXDWABBSQMGEJR-UHFFFAOYSA-N 0.000 claims description 5
VYDHPNAPJHQGAQ-UHFFFAOYSA-N [4-oxo-3-phenyl-4-(2,2,2-trifluoroethylamino)butyl] 4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzoate Chemical compound C=1C=CC=CC=1C(C(=O)NCC(F)(F)F)CCOC(=O)C(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 VYDHPNAPJHQGAQ-UHFFFAOYSA-N 0.000 claims description 5
125000004183 alkoxy alkyl group Chemical group 0.000 claims description 5
125000005129 aryl carbonyl group Chemical group 0.000 claims description 5
PKOJLUDOEGKHKD-UHFFFAOYSA-N ethyl 3-[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxy-2-phenylpropanoate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 PKOJLUDOEGKHKD-UHFFFAOYSA-N 0.000 claims description 5
238000006467 substitution reaction Methods 0.000 claims description 5
125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims description 4
HLUWFXKPBGTSOT-UHFFFAOYSA-N 2-(9h-fluoren-9-yl)ethyl 4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzoate Chemical compound C1=CC(C(F)(F)F)=CC=C1C1=CC=CC=C1C(=O)NC1=CC=C(C(=O)OCCC2C3=CC=CC=C3C3=CC=CC=C32)C=C1 HLUWFXKPBGTSOT-UHFFFAOYSA-N 0.000 claims description 4
BPLZZZYKPMISHF-UHFFFAOYSA-N 2-[9-(2,2,2-trifluoroethylcarbamoyl)fluoren-9-yl]ethyl 4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzoate Chemical compound C12=CC=CC=C2C2=CC=CC=C2C1(C(=O)NCC(F)(F)F)CCOC(=O)C(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 BPLZZZYKPMISHF-UHFFFAOYSA-N 0.000 claims description 4
FELAMXYHUCLVLZ-UHFFFAOYSA-N 2-[9-(2,2,2-trifluoroethylcarbamoyl)fluoren-9-yl]ethyl 4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]cyclohexane-1-carboxylate Chemical compound C12=CC=CC=C2C2=CC=CC=C2C1(C(=O)NCC(F)(F)F)CCOC(=O)C(CC1)CCC1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 FELAMXYHUCLVLZ-UHFFFAOYSA-N 0.000 claims description 4
WPHZSDSUNGMDNZ-UHFFFAOYSA-N [2-phenyl-2-(propan-2-ylamino)ethyl] 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate;hydrochloride Chemical compound Cl.C=1C=CC=CC=1C(NC(C)C)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 WPHZSDSUNGMDNZ-UHFFFAOYSA-N 0.000 claims description 4
NWHUYASNTIKNOX-UHFFFAOYSA-N [3-oxo-2-phenyl-3-(2,2,2-trifluoroethylamino)propyl] 2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC(F)(F)F)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 NWHUYASNTIKNOX-UHFFFAOYSA-N 0.000 claims description 4
ZXCNSRLVOOZZRJ-UHFFFAOYSA-N [9-(2,2,2-trifluoroethylcarbamoyl)fluoren-9-yl]methyl 2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C12=CC=CC=C2C2=CC=CC=C2C1(C(=O)NCC(F)(F)F)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 ZXCNSRLVOOZZRJ-UHFFFAOYSA-N 0.000 claims description 4
125000004429 atom Chemical group 0.000 claims description 4
229910052799 carbon Inorganic materials 0.000 claims description 4
LNDCJRVFEHFSGY-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-(2-methylpropyl)propanedioate Chemical compound CN(C)C(=O)C1=CC(CC(=O)OCC(C(=O)OCC)(CC(C)C)C(=O)OCC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 LNDCJRVFEHFSGY-UHFFFAOYSA-N 0.000 claims description 4
YKPUYMWQTKCPGG-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-ethylpropanedioate Chemical compound CN(C)C(=O)C1=CC(CC(=O)OCC(CC)(C(=O)OCC)C(=O)OCC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 YKPUYMWQTKCPGG-UHFFFAOYSA-N 0.000 claims description 4
FFBWXDCAVXXPJM-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-propan-2-ylpropanedioate Chemical compound CN(C)C(=O)C1=CC(CC(=O)OCC(C(=O)OCC)(C(C)C)C(=O)OCC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 FFBWXDCAVXXPJM-UHFFFAOYSA-N 0.000 claims description 4
QJAXNITURXHNKQ-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-propylpropanedioate Chemical compound CN(C)C(=O)C1=CC(CC(=O)OCC(CCC)(C(=O)OCC)C(=O)OCC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 QJAXNITURXHNKQ-UHFFFAOYSA-N 0.000 claims description 4
PPPLMCQFIDTZCV-UHFFFAOYSA-N diethyl 2-butan-2-yl-2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound CN(C)C(=O)C1=CC(CC(=O)OCC(C(=O)OCC)(C(C)CC)C(=O)OCC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 PPPLMCQFIDTZCV-UHFFFAOYSA-N 0.000 claims description 4
XDJRZVUNVPCRHF-UHFFFAOYSA-N diethyl 2-butyl-2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound CN(C)C(=O)C1=CC(CC(=O)OCC(CCCC)(C(=O)OCC)C(=O)OCC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 XDJRZVUNVPCRHF-UHFFFAOYSA-N 0.000 claims description 4
125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims description 4
125000003548 sec-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 4
125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims description 3
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YUNQRDJOOWZLOS-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[4-[2-[4-(trifluoromethyl)phenyl]benzoyl]oxyphenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1OC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 YUNQRDJOOWZLOS-UHFFFAOYSA-N 0.000 description 7
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WAIYBHJEIRHQGY-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-(2-methylpropyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1CC(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 WAIYBHJEIRHQGY-UHFFFAOYSA-N 0.000 description 6
HKQLLOCMUWZCAB-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-(benzylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1C(=O)NCC=2C=CC=CC=2)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 HKQLLOCMUWZCAB-UHFFFAOYSA-N 0.000 description 6
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FWKFITSVDODGAF-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-(piperidine-1-carbonyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1C(=O)N2CCCCC2)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 FWKFITSVDODGAF-UHFFFAOYSA-N 0.000 description 6
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VHCRJSOJSAMPCR-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-ethoxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1OCC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 VHCRJSOJSAMPCR-UHFFFAOYSA-N 0.000 description 6
FCRDUDHCGYHDDW-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-methoxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1OC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 FCRDUDHCGYHDDW-UHFFFAOYSA-N 0.000 description 6
UCMNZVKXQRAGGY-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-methyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 UCMNZVKXQRAGGY-UHFFFAOYSA-N 0.000 description 6
DZVCVGDQRQMIGL-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-piperidin-1-yl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1N2CCCCC2)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 DZVCVGDQRQMIGL-UHFFFAOYSA-N 0.000 description 6
SOMZASTXYLSNTM-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-propan-2-yl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1C(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 SOMZASTXYLSNTM-UHFFFAOYSA-N 0.000 description 6
KCMCSGBVERRGNI-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-propan-2-yloxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1OC(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 KCMCSGBVERRGNI-UHFFFAOYSA-N 0.000 description 6
GOMHCLVRTCQSTR-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-propoxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=C(NC(=O)C=2C(=CC=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(OCCC)=CC=1CC(=O)OCC(C(=O)NCC)(C(=O)NCC)C1=CC=CC=C1 GOMHCLVRTCQSTR-UHFFFAOYSA-N 0.000 description 6
QEZKAQXBQPBBBT-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[3-pyrrolidin-1-yl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1N2CCCC2)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 QEZKAQXBQPBBBT-UHFFFAOYSA-N 0.000 description 6
ZYHNGVIIMSMQEY-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[4-[(2-phenylbenzoyl)amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=CC=C1 ZYHNGVIIMSMQEY-UHFFFAOYSA-N 0.000 description 6
HOSCJSLPFBRCOK-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[4-[[2-(3,4-dichlorophenyl)benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(Cl)C(Cl)=C1 HOSCJSLPFBRCOK-UHFFFAOYSA-N 0.000 description 6
UKWCRRMWWDPWIC-UHFFFAOYSA-N [3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[4-[[2-(4-chlorophenyl)benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(Cl)C=C1 UKWCRRMWWDPWIC-UHFFFAOYSA-N 0.000 description 6
WVWLTHWFFAXMBN-UHFFFAOYSA-N [3-(methylamino)-2-(methylcarbamoyl)-3-oxo-2-phenylpropyl] 2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NC)(C(=O)NC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 WVWLTHWFFAXMBN-UHFFFAOYSA-N 0.000 description 6
YGRZKEKEFVYSER-UHFFFAOYSA-N [3-anilino-3-oxo-2-phenyl-2-(phenylcarbamoyl)propyl] 2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C1=CC(C(F)(F)F)=CC=C1C1=CC=CC=C1C(=O)NC(C=C1)=CC=C1CC(=O)OCC(C=1C=CC=CC=1)(C(=O)NC=1C=CC=CC=1)C(=O)NC1=CC=CC=C1 YGRZKEKEFVYSER-UHFFFAOYSA-N 0.000 description 6
GYBGTVFSTMDCJK-UHFFFAOYSA-N [3-oxo-2-phenyl-3-(2,2,2-trifluoroethylamino)-2-(2,2,2-trifluoroethylcarbamoyl)propyl] 2-[4-[(2-phenylbenzoyl)amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC(F)(F)F)(C(=O)NCC(F)(F)F)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=CC=C1 GYBGTVFSTMDCJK-UHFFFAOYSA-N 0.000 description 6
ZWQZMSAKNTZADX-UHFFFAOYSA-N [3-oxo-2-phenyl-3-(2,2,2-trifluoroethylamino)-2-(2,2,2-trifluoroethylcarbamoyl)propyl] 2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC(F)(F)F)(C(=O)NCC(F)(F)F)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 ZWQZMSAKNTZADX-UHFFFAOYSA-N 0.000 description 6
XGRAWMZOYKHADZ-UHFFFAOYSA-N [3-oxo-2-phenyl-3-(propan-2-ylamino)-2-(propan-2-ylcarbamoyl)propyl] 2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NC(C)C)(C(=O)NC(C)C)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 XGRAWMZOYKHADZ-UHFFFAOYSA-N 0.000 description 6
DEEWGADMSNAMJZ-UHFFFAOYSA-N [3-oxo-2-phenyl-3-(propylamino)-2-(propylcarbamoyl)propyl] 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCCC)(C(=O)NCCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 DEEWGADMSNAMJZ-UHFFFAOYSA-N 0.000 description 6
DONVKTBFBUILDH-UHFFFAOYSA-N [3-oxo-2-phenyl-3-(propylamino)-2-(propylcarbamoyl)propyl] 2-[3-methoxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCCC)(C(=O)NCCC)COC(=O)CC(C=C1OC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 DONVKTBFBUILDH-UHFFFAOYSA-N 0.000 description 6
HBQNCNWIWAUDEO-UHFFFAOYSA-N [3-oxo-2-phenyl-3-(propylamino)-2-(propylcarbamoyl)propyl] 2-[3-methyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCCC)(C(=O)NCCC)COC(=O)CC(C=C1C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 HBQNCNWIWAUDEO-UHFFFAOYSA-N 0.000 description 6
LHFAGDIJHIHIFC-UHFFFAOYSA-N [4-(ethylamino)-3-(ethylcarbamoyl)-4-oxo-3-phenylbutyl] 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)CCOC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 LHFAGDIJHIHIFC-UHFFFAOYSA-N 0.000 description 6
HIBYADHVPNNANO-UHFFFAOYSA-N [4-(ethylamino)-3-(ethylcarbamoyl)-4-oxo-3-phenylbutyl] 2-[3-[ethyl(methyl)carbamoyl]-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)CCOC(=O)CC(C=C1C(=O)N(C)CC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 HIBYADHVPNNANO-UHFFFAOYSA-N 0.000 description 6
QRDINOXMOOVSQB-UHFFFAOYSA-N [4-(ethylamino)-3-(ethylcarbamoyl)-4-oxo-3-phenylbutyl] 2-[3-[methyl(propyl)carbamoyl]-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=C(NC(=O)C=2C(=CC=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(C(=O)N(C)CCC)=CC=1CC(=O)OCCC(C(=O)NCC)(C(=O)NCC)C1=CC=CC=C1 QRDINOXMOOVSQB-UHFFFAOYSA-N 0.000 description 6
FURGMBSIHLXZPV-UHFFFAOYSA-N [4-(ethylamino)-3-(ethylcarbamoyl)-4-oxo-3-phenylbutyl] 2-[3-ethoxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)CCOC(=O)CC(C=C1OCC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 FURGMBSIHLXZPV-UHFFFAOYSA-N 0.000 description 6
VKQWBAHJJDDKIS-UHFFFAOYSA-N [4-(ethylamino)-3-(ethylcarbamoyl)-4-oxo-3-phenylbutyl] 2-[3-ethyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)CCOC(=O)CC(C=C1CC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 VKQWBAHJJDDKIS-UHFFFAOYSA-N 0.000 description 6
XWFCGZFKTKCKQH-UHFFFAOYSA-N [4-(ethylamino)-3-(ethylcarbamoyl)-4-oxo-3-phenylbutyl] 2-[3-methoxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)CCOC(=O)CC(C=C1OC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 XWFCGZFKTKCKQH-UHFFFAOYSA-N 0.000 description 6
NJEHRVLBDMDIMY-UHFFFAOYSA-N [4-(ethylamino)-3-(ethylcarbamoyl)-4-oxo-3-phenylbutyl] 2-[3-propan-2-yloxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)CCOC(=O)CC(C=C1OC(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 NJEHRVLBDMDIMY-UHFFFAOYSA-N 0.000 description 6
AASLRCUIMHVVAU-UHFFFAOYSA-N [4-(ethylamino)-3-(ethylcarbamoyl)-4-oxo-3-phenylbutyl] 2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)CCOC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 AASLRCUIMHVVAU-UHFFFAOYSA-N 0.000 description 6
WEUZMSLVMQPRIK-UHFFFAOYSA-N [4-(ethylamino)-3-(ethylcarbamoyl)-4-oxo-3-phenylbutyl] 3,5-dichloro-4-[2-[4-(trifluoromethyl)phenyl]benzoyl]oxybenzoate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)CCOC(=O)C(C=C1Cl)=CC(Cl)=C1OC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 WEUZMSLVMQPRIK-UHFFFAOYSA-N 0.000 description 6
NIIOQUAZHXNTQW-UHFFFAOYSA-N [4-(ethylamino)-3-(ethylcarbamoyl)-4-oxo-3-phenylbutyl] 4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzoate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)CCOC(=O)C(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 NIIOQUAZHXNTQW-UHFFFAOYSA-N 0.000 description 6
PFXWMKPZCNOEGO-UHFFFAOYSA-N [4-[2-oxo-2-[3-oxo-2-phenyl-3-(2,2,2-trifluoroethylamino)-2-(2,2,2-trifluoroethylcarbamoyl)propoxy]ethyl]phenyl] 2-[4-(trifluoromethyl)phenyl]benzoate Chemical compound C=1C=CC=CC=1C(C(=O)NCC(F)(F)F)(C(=O)NCC(F)(F)F)COC(=O)CC(C=C1)=CC=C1OC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 PFXWMKPZCNOEGO-UHFFFAOYSA-N 0.000 description 6
DMFXDHPZDPSKKE-UHFFFAOYSA-N [4-[2-oxo-2-[3-oxo-2-phenyl-3-(2,2,2-trifluoroethylamino)-2-(2,2,2-trifluoroethylcarbamoyl)propoxy]ethyl]phenyl] 2-phenylbenzoate Chemical compound C=1C=CC=CC=1C(C(=O)NCC(F)(F)F)(C(=O)NCC(F)(F)F)COC(=O)CC(C=C1)=CC=C1OC(=O)C1=CC=CC=C1C1=CC=CC=C1 DMFXDHPZDPSKKE-UHFFFAOYSA-N 0.000 description 6
BGFXOQFHFAXQIL-UHFFFAOYSA-N [4-[4-(ethylamino)-3-(ethylcarbamoyl)-4-oxo-3-phenylbutoxy]carbonylphenyl] 2-[4-(trifluoromethyl)phenyl]benzoate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)CCOC(=O)C(C=C1)=CC=C1OC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 BGFXOQFHFAXQIL-UHFFFAOYSA-N 0.000 description 6
SEQUXWDZPPNBFG-UHFFFAOYSA-N [4-oxo-3-phenyl-4-(propylamino)-3-(propylcarbamoyl)butyl] 2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCCC)(C(=O)NCCC)CCOC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 SEQUXWDZPPNBFG-UHFFFAOYSA-N 0.000 description 6
KMOJSUYDGMMPKZ-UHFFFAOYSA-N [5-(ethylamino)-4-(ethylcarbamoyl)-5-oxo-4-phenylpentyl] 2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)CCCOC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 KMOJSUYDGMMPKZ-UHFFFAOYSA-N 0.000 description 6
239000002220 antihypertensive agent Substances 0.000 description 6
IUGQFMIATSVYLK-UHFFFAOYSA-N benzyl 2-(4-hydroxyphenyl)acetate Chemical compound C1=CC(O)=CC=C1CC(=O)OCC1=CC=CC=C1 IUGQFMIATSVYLK-UHFFFAOYSA-N 0.000 description 6
LUYWZYCPFLPYCW-UHFFFAOYSA-N benzyl 5-[2-[3-(ethylamino)-2-(ethylcarbamoyl)-3-oxo-2-phenylpropoxy]-2-oxoethyl]-2-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzoate Chemical compound C=1C=CC=CC=1C(C(=O)NCC)(C(=O)NCC)COC(=O)CC(C=C1C(=O)OCC=2C=CC=CC=2)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 LUYWZYCPFLPYCW-UHFFFAOYSA-N 0.000 description 6
239000002876 beta blocker Substances 0.000 description 6
229940097320 beta blocking agent Drugs 0.000 description 6
WCHYAQSECVPREY-UHFFFAOYSA-N bis(2-methylpropyl) 2-phenyl-2-[[2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC(C)C)(C(=O)OCC(C)C)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 WCHYAQSECVPREY-UHFFFAOYSA-N 0.000 description 6
229960003612 bunazosin hydrochloride Drugs 0.000 description 6
VCVQSRCYSKKPBA-UHFFFAOYSA-N bunitrolol Chemical compound CC(C)(C)NCC(O)COC1=CC=CC=C1C#N VCVQSRCYSKKPBA-UHFFFAOYSA-N 0.000 description 6
229950008581 bunitrolol Drugs 0.000 description 6
239000002775 capsule Substances 0.000 description 6
229960000830 captopril Drugs 0.000 description 6
FAKRSMQSSFJEIM-RQJHMYQMSA-N captopril Chemical compound SC[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O FAKRSMQSSFJEIM-RQJHMYQMSA-N 0.000 description 6
FYBXRCFPOTXTJF-UHFFFAOYSA-N carteolol hydrochloride Chemical compound [Cl-].N1C(=O)CCC2=C1C=CC=C2OCC(O)C[NH2+]C(C)(C)C FYBXRCFPOTXTJF-UHFFFAOYSA-N 0.000 description 6
229960002165 carteolol hydrochloride Drugs 0.000 description 6
230000003197 catalytic effect Effects 0.000 description 6
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 6
238000006264 debenzylation reaction Methods 0.000 description 6
238000006114 decarboxylation reaction Methods 0.000 description 6
NMGIQDDNASBFBY-UHFFFAOYSA-N dicyclohexyl 2-phenyl-2-[[2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C1=CC(C(F)(F)F)=CC=C1C1=CC=CC=C1C(=O)NC(C=C1)=CC=C1CC(=O)OCC(C=1C=CC=CC=1)(C(=O)OC1CCCCC1)C(=O)OC1CCCCC1 NMGIQDDNASBFBY-UHFFFAOYSA-N 0.000 description 6
KADUHNHNLIGUPU-UHFFFAOYSA-N diethyl 2-(5-aminopyridin-2-yl)-2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=C(N)C=NC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 KADUHNHNLIGUPU-UHFFFAOYSA-N 0.000 description 6
DGZFWSSCJDGXTC-UHFFFAOYSA-N diethyl 2-[2-[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxyethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)CCOC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 DGZFWSSCJDGXTC-UHFFFAOYSA-N 0.000 description 6
WDDZGKRLQQENAE-UHFFFAOYSA-N diethyl 2-[2-[2-[3-(dimethylcarbamoyl)-4-[[4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxyethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)CCOC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=C(C(F)(F)F)C=C1C1=CC=C(C(F)(F)F)C=C1 WDDZGKRLQQENAE-UHFFFAOYSA-N 0.000 description 6
ZOLGRHUWNCZOFY-UHFFFAOYSA-N diethyl 2-[2-[2-[3-(dimethylcarbamoyl)-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxyethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)CCOC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=C(C)C=C1C1=CC=C(C(F)(F)F)C=C1 ZOLGRHUWNCZOFY-UHFFFAOYSA-N 0.000 description 6
KZKOOWGZUAINSN-UHFFFAOYSA-N diethyl 2-[2-[2-chloro-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]benzoyl]oxyethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)CCOC(=O)C(C(=C1)Cl)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 KZKOOWGZUAINSN-UHFFFAOYSA-N 0.000 description 6
YHQGUNJPAAVYRT-UHFFFAOYSA-N diethyl 2-[3-[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxypropyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)CCCOC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 YHQGUNJPAAVYRT-UHFFFAOYSA-N 0.000 description 6
RXQBXNWFJRSNLR-UHFFFAOYSA-N diethyl 2-[3-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]propanoyloxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CCC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 RXQBXNWFJRSNLR-UHFFFAOYSA-N 0.000 description 6
PQYQHQHKLZPUGP-UHFFFAOYSA-N diethyl 2-[[2-[2-methyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C(=C1)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 PQYQHQHKLZPUGP-UHFFFAOYSA-N 0.000 description 6
ZCFVKPQPKGPBJV-UHFFFAOYSA-N diethyl 2-[[2-[3-(2-methylpropanoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)C(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 ZCFVKPQPKGPBJV-UHFFFAOYSA-N 0.000 description 6
VJHDWFVDJGEATB-UHFFFAOYSA-N diethyl 2-[[2-[3-(2-methylpropyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1CC(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 VJHDWFVDJGEATB-UHFFFAOYSA-N 0.000 description 6
KGENKWUIWLJMTO-UHFFFAOYSA-N diethyl 2-[[2-[3-(4-methyl-1,3-thiazol-2-yl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C=2SC=C(C)N=2)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 KGENKWUIWLJMTO-UHFFFAOYSA-N 0.000 description 6
XIRSBALRSUGZJS-UHFFFAOYSA-N diethyl 2-[[2-[3-(diethylamino)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1N(CC)CC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 XIRSBALRSUGZJS-UHFFFAOYSA-N 0.000 description 6
DNIUSHRQIMHNGP-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylamino)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 DNIUSHRQIMHNGP-UHFFFAOYSA-N 0.000 description 6
YADROHWZRUUBQB-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[2-[4-(trifluoromethyl)phenyl]benzoyl]oxyphenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1OC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 YADROHWZRUUBQB-UHFFFAOYSA-N 0.000 description 6
DHGVRVNVNPHFIK-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-(4-ethylphenyl)benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(CC)C=C1 DHGVRVNVNPHFIK-UHFFFAOYSA-N 0.000 description 6
ITUZZAFKZDHVQE-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-(4-fluorophenyl)benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(F)C=C1 ITUZZAFKZDHVQE-UHFFFAOYSA-N 0.000 description 6
ZBSOGIQKERKSCH-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-(4-methylphenyl)benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C)C=C1 ZBSOGIQKERKSCH-UHFFFAOYSA-N 0.000 description 6
CQQKNFFDPBRYCS-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-(4-prop-1-en-2-ylphenyl)benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(C)=C)C=C1 CQQKNFFDPBRYCS-UHFFFAOYSA-N 0.000 description 6
TVZOEIGIFBAXHY-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-(4-propan-2-ylphenyl)benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(C)C)C=C1 TVZOEIGIFBAXHY-UHFFFAOYSA-N 0.000 description 6
YHNSSFYTXVDPMR-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[2-fluoro-4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1F YHNSSFYTXVDPMR-UHFFFAOYSA-N 0.000 description 6
LHQHRAXQAXGXQN-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[3-fluoro-4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C(F)=C1 LHQHRAXQAXGXQN-UHFFFAOYSA-N 0.000 description 6
OFPAVWJFHPRWJZ-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-(1,3-thiazol-2-yl)propanedioate Chemical compound N=1C=CSC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 OFPAVWJFHPRWJZ-UHFFFAOYSA-N 0.000 description 6
UQNZJMYBNXNYTD-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-(2-methylphenyl)propanedioate Chemical compound C=1C=CC=C(C)C=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 UQNZJMYBNXNYTD-UHFFFAOYSA-N 0.000 description 6
RHQFACXKVAZQEQ-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-(3-methylphenyl)propanedioate Chemical compound C=1C=CC(C)=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 RHQFACXKVAZQEQ-UHFFFAOYSA-N 0.000 description 6
PKPOUGBPUSRAEB-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-(3-methylthiophen-2-yl)propanedioate Chemical compound S1C=CC(C)=C1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 PKPOUGBPUSRAEB-UHFFFAOYSA-N 0.000 description 6
UDLMNDUFPKUJSY-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-(4-methylphenyl)propanedioate Chemical compound C=1C=C(C)C=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 UDLMNDUFPKUJSY-UHFFFAOYSA-N 0.000 description 6
XPRIDZRFMYZQSM-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-(5-methylthiophen-2-yl)propanedioate Chemical compound C=1C=C(C)SC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 XPRIDZRFMYZQSM-UHFFFAOYSA-N 0.000 description 6
XEMLRDPGOJPHDL-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-(5-nitropyridin-2-yl)propanedioate Chemical compound C=1C=C([N+]([O-])=O)C=NC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 XEMLRDPGOJPHDL-UHFFFAOYSA-N 0.000 description 6
ARYPVXBIDOGRHU-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylbutanedioate Chemical compound C=1C=CC=CC=1C(CC(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 ARYPVXBIDOGRHU-UHFFFAOYSA-N 0.000 description 6
FPUQGCOBYOXAED-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 FPUQGCOBYOXAED-UHFFFAOYSA-N 0.000 description 6
ZBORAOCCJCJTHA-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-pyridin-2-ylpropanedioate Chemical compound C=1C=CC=NC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 ZBORAOCCJCJTHA-UHFFFAOYSA-N 0.000 description 6
DAPBKZSHKPPWKF-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-thiophen-2-ylpropanedioate Chemical compound C=1C=CSC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 DAPBKZSHKPPWKF-UHFFFAOYSA-N 0.000 description 6
NEBLXFSOGXOHGE-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-thiophen-3-ylpropanedioate Chemical compound C1=CSC=C1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 NEBLXFSOGXOHGE-UHFFFAOYSA-N 0.000 description 6
IOUAIYUEZSPYQI-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-ethyl-4-(trifluoromethyl)benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=C(C(F)(F)F)C=C1CC IOUAIYUEZSPYQI-UHFFFAOYSA-N 0.000 description 6
RQAZMVFZXSXJJY-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-methyl-6-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=C(C)C=CC=C1C1=CC=C(C(F)(F)F)C=C1 RQAZMVFZXSXJJY-UHFFFAOYSA-N 0.000 description 6
UQVFFSRYZKEVAA-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[3-fluoro-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC(F)=C1C1=CC=C(C(F)(F)F)C=C1 UQVFFSRYZKEVAA-UHFFFAOYSA-N 0.000 description 6
NSHDBBXTDASVHG-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[3-methoxy-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC(OC)=C1C1=CC=C(C(F)(F)F)C=C1 NSHDBBXTDASVHG-UHFFFAOYSA-N 0.000 description 6
TXZREXQQNQNFOJ-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[3-methyl-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC(C)=C1C1=CC=C(C(F)(F)F)C=C1 TXZREXQQNQNFOJ-UHFFFAOYSA-N 0.000 description 6
NKGWHTODKOYZMP-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=C(C(F)(F)F)C=C1C1=CC=C(C(F)(F)F)C=C1 NKGWHTODKOYZMP-UHFFFAOYSA-N 0.000 description 6
YMWUDKGZMSDSCV-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[4-ethoxy-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=C(OCC)C=C1C1=CC=C(C(F)(F)F)C=C1 YMWUDKGZMSDSCV-UHFFFAOYSA-N 0.000 description 6
OZOLXOKXJZKKAP-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[4-methoxy-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=C(OC)C=C1C1=CC=C(C(F)(F)F)C=C1 OZOLXOKXJZKKAP-UHFFFAOYSA-N 0.000 description 6
AQAQSTFAUQIWBD-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=C(C)C=C1C1=CC=C(C(F)(F)F)C=C1 AQAQSTFAUQIWBD-UHFFFAOYSA-N 0.000 description 6
QKDJFYOBSFGMFD-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[4-propan-2-yloxy-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=C(OC(C)C)C=C1C1=CC=C(C(F)(F)F)C=C1 QKDJFYOBSFGMFD-UHFFFAOYSA-N 0.000 description 6
FMXXDZOSHNWORQ-UHFFFAOYSA-N diethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[5-methyl-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC(C)=CC=C1C1=CC=C(C(F)(F)F)C=C1 FMXXDZOSHNWORQ-UHFFFAOYSA-N 0.000 description 6
VOCOBGKMMMDCLO-UHFFFAOYSA-N diethyl 2-[[2-[3-(methoxycarbonylamino)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1NC(=O)OC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 VOCOBGKMMMDCLO-UHFFFAOYSA-N 0.000 description 6
JPLWDRVFJCTLTM-UHFFFAOYSA-N diethyl 2-[[2-[3-[(dimethylamino)methyl]-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1CN(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 JPLWDRVFJCTLTM-UHFFFAOYSA-N 0.000 description 6
XFWHHJAJDSGMDJ-UHFFFAOYSA-N diethyl 2-[[2-[3-[di(propan-2-yl)carbamoyl]-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C(C)C)C(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 XFWHHJAJDSGMDJ-UHFFFAOYSA-N 0.000 description 6
WDYJRWDDNFJIIF-UHFFFAOYSA-N diethyl 2-[[2-[3-[ethyl(methyl)carbamoyl]-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)CC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 WDYJRWDDNFJIIF-UHFFFAOYSA-N 0.000 description 6
AONKRNBFMYDDNY-UHFFFAOYSA-N diethyl 2-[[2-[3-[methoxy(methyl)carbamoyl]-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)OC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 AONKRNBFMYDDNY-UHFFFAOYSA-N 0.000 description 6
BFLQTUDYSYNTFK-UHFFFAOYSA-N diethyl 2-[[2-[3-acetamido-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1NC(C)=O)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 BFLQTUDYSYNTFK-UHFFFAOYSA-N 0.000 description 6
QSALIZYUAMVOJD-UHFFFAOYSA-N diethyl 2-[[2-[3-bromo-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1Br)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 QSALIZYUAMVOJD-UHFFFAOYSA-N 0.000 description 6
DITBXJLZCBMEJK-UHFFFAOYSA-N diethyl 2-[[2-[3-bromo-5-(dimethylcarbamoyl)-2-fluoro-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C(=C1Br)F)=CC(C(=O)N(C)C)=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 DITBXJLZCBMEJK-UHFFFAOYSA-N 0.000 description 6
VLJMVLJVRQYUNA-UHFFFAOYSA-N diethyl 2-[[2-[3-bromo-5-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC(Br)=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 VLJMVLJVRQYUNA-UHFFFAOYSA-N 0.000 description 6
BJYOVAQOPCNJJZ-UHFFFAOYSA-N diethyl 2-[[2-[3-chloro-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1Cl)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 BJYOVAQOPCNJJZ-UHFFFAOYSA-N 0.000 description 6
JIGCNLSLFSZUBN-UHFFFAOYSA-N diethyl 2-[[2-[3-chloro-5-(dimethylcarbamoyl)-2-fluoro-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C(=C1Cl)F)=CC(C(=O)N(C)C)=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 JIGCNLSLFSZUBN-UHFFFAOYSA-N 0.000 description 6
JQVSERUQWKUTNM-UHFFFAOYSA-N diethyl 2-[[2-[3-chloro-5-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC(Cl)=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 JQVSERUQWKUTNM-UHFFFAOYSA-N 0.000 description 6
JNNUTCZXEWHFAE-UHFFFAOYSA-N diethyl 2-[[2-[3-ethoxycarbonyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=C(NC(=O)C=2C(=CC=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(C(=O)OCC)=CC=1CC(=O)OCC(C(=O)OCC)(C(=O)OCC)C1=CC=CC=C1 JNNUTCZXEWHFAE-UHFFFAOYSA-N 0.000 description 6
JJNIUYYXGTZUAE-UHFFFAOYSA-N diethyl 2-[[2-[3-ethyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1CC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 JJNIUYYXGTZUAE-UHFFFAOYSA-N 0.000 description 6
QYBKHGFPCWVXGA-UHFFFAOYSA-N diethyl 2-[[2-[3-formyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C=O)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 QYBKHGFPCWVXGA-UHFFFAOYSA-N 0.000 description 6
UQMLHUONUHEPTG-UHFFFAOYSA-N diethyl 2-[[2-[3-hydroxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1O)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 UQMLHUONUHEPTG-UHFFFAOYSA-N 0.000 description 6
ZSFJTLSWCMMWQS-UHFFFAOYSA-N diethyl 2-[[2-[3-methoxy-4-[2-[4-(trifluoromethyl)phenyl]benzoyl]oxyphenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1OC)=CC=C1OC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 ZSFJTLSWCMMWQS-UHFFFAOYSA-N 0.000 description 6
WCSFLQQQRIFLOM-UHFFFAOYSA-N diethyl 2-[[2-[3-methoxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1OC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 WCSFLQQQRIFLOM-UHFFFAOYSA-N 0.000 description 6
JTSALHZINIJVKA-UHFFFAOYSA-N diethyl 2-[[2-[3-methoxycarbonyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)OC)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 JTSALHZINIJVKA-UHFFFAOYSA-N 0.000 description 6
PWHCSPVQLQMAKI-UHFFFAOYSA-N diethyl 2-[[2-[3-morpholin-4-yl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1N2CCOCC2)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 PWHCSPVQLQMAKI-UHFFFAOYSA-N 0.000 description 6
QPWRSIOICZIZFE-UHFFFAOYSA-N diethyl 2-[[2-[4-(dimethylcarbamoyl)-5-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]pyridin-2-yl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(N=C1)=CC(C(=O)N(C)C)=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 QPWRSIOICZIZFE-UHFFFAOYSA-N 0.000 description 6
JXDJXXNXUMYJAM-UHFFFAOYSA-N diethyl 2-[[2-[4-[[2,4-bis(trifluoromethyl)benzoyl]amino]-3-(dimethylcarbamoyl)phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=C(C(F)(F)F)C=C1C(F)(F)F JXDJXXNXUMYJAM-UHFFFAOYSA-N 0.000 description 6
XFTJHJQRJIJEJH-UHFFFAOYSA-N diethyl 2-[[2-[4-[[2-(4-acetylphenyl)benzoyl]amino]-3-(dimethylcarbamoyl)phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(C)=O)C=C1 XFTJHJQRJIJEJH-UHFFFAOYSA-N 0.000 description 6
JRWZHGOZIIGYDU-UHFFFAOYSA-N diethyl 2-[[2-[4-[[2-(4-bromophenyl)benzoyl]amino]-3-(dimethylcarbamoyl)phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(Br)C=C1 JRWZHGOZIIGYDU-UHFFFAOYSA-N 0.000 description 6
JNZGMEMZRZAERN-UHFFFAOYSA-N diethyl 2-[[2-[4-[[2-(4-chlorophenyl)benzoyl]amino]-3-(dimethylcarbamoyl)phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(Cl)C=C1 JNZGMEMZRZAERN-UHFFFAOYSA-N 0.000 description 6
KGCDKDLWNXXRFV-UHFFFAOYSA-N diethyl 2-[[2-[4-[[2-(4-cyanophenyl)benzoyl]amino]-3-(dimethylcarbamoyl)phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C#N)C=C1 KGCDKDLWNXXRFV-UHFFFAOYSA-N 0.000 description 6
LZCHVDSKNDHAOJ-UHFFFAOYSA-N diethyl 2-[[2-[4-[[2-(4-methoxyphenyl)benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(OC)C=C1 LZCHVDSKNDHAOJ-UHFFFAOYSA-N 0.000 description 6
BGLKZLSYHVCCKG-UHFFFAOYSA-N diethyl 2-[[2-[4-[[2-(4-methylphenyl)benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C)C=C1 BGLKZLSYHVCCKG-UHFFFAOYSA-N 0.000 description 6
BHNMYNFFQOTSHQ-UHFFFAOYSA-N diethyl 2-[[2-[4-[[2-[3-chloro-4-(trifluoromethyl)phenyl]benzoyl]amino]-3-(dimethylcarbamoyl)phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C(Cl)=C1 BHNMYNFFQOTSHQ-UHFFFAOYSA-N 0.000 description 6
ULLUGLVTASFFSI-UHFFFAOYSA-N diethyl 2-[[2-[4-[[3-chloro-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-3-(dimethylcarbamoyl)phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC(Cl)=C1C1=CC=C(C(F)(F)F)C=C1 ULLUGLVTASFFSI-UHFFFAOYSA-N 0.000 description 6
KNZWSIOXCHPTIY-UHFFFAOYSA-N diethyl 2-[[2-[4-[[4-chloro-2-[4-(trifluoromethyl)phenyl]benzoyl]amino]-3-(dimethylcarbamoyl)phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=C(Cl)C=C1C1=CC=C(C(F)(F)F)C=C1 KNZWSIOXCHPTIY-UHFFFAOYSA-N 0.000 description 6
RHQODGJKTHSOSK-UHFFFAOYSA-N diethyl 2-[[2-[4-[cyclohexyl-[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1N(C(=O)C=1C(=CC=CC=1)C=1C=CC(=CC=1)C(F)(F)F)C1CCCCC1 RHQODGJKTHSOSK-UHFFFAOYSA-N 0.000 description 6
BYZSMHCEVWSYNZ-UHFFFAOYSA-N diethyl 2-[[2-[4-[ethyl-[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1N(CC)C(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 BYZSMHCEVWSYNZ-UHFFFAOYSA-N 0.000 description 6
XKIOHZHJOXNEDD-UHFFFAOYSA-N diethyl 2-[[2-[5-(dimethylcarbamoyl)-2-fluoro-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C(=C1)F)=CC(C(=O)N(C)C)=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 XKIOHZHJOXNEDD-UHFFFAOYSA-N 0.000 description 6
AUZVZFRTWPBNSU-UHFFFAOYSA-N diethyl 2-cyclohexyl-2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C1CCCCC1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 AUZVZFRTWPBNSU-UHFFFAOYSA-N 0.000 description 6
CAUSRFIXGJUMIM-UHFFFAOYSA-N diethyl 2-cyclohexyl-2-[[2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C1CCCCC1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 CAUSRFIXGJUMIM-UHFFFAOYSA-N 0.000 description 6
WNAGUAJYPFLTNP-UHFFFAOYSA-N diethyl 2-cyclopentyl-2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C1CCCC1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 WNAGUAJYPFLTNP-UHFFFAOYSA-N 0.000 description 6
XSURSZJBHYZJJO-UHFFFAOYSA-N diethyl 2-cyclopentyl-2-[[2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C1CCCC1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 XSURSZJBHYZJJO-UHFFFAOYSA-N 0.000 description 6
OHSMIXHPCYFYCG-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[3-(piperidine-1-carbonyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N2CCCCC2)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 OHSMIXHPCYFYCG-UHFFFAOYSA-N 0.000 description 6
ZEHFIMSMADZESI-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[3-(pyrrolidine-1-carbonyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)N2CCCC2)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 ZEHFIMSMADZESI-UHFFFAOYSA-N 0.000 description 6
LZKKTMHAHINRDI-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[3-(trifluoromethyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(F)(F)F)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 LZKKTMHAHINRDI-UHFFFAOYSA-N 0.000 description 6
BZBRIHBDVDUCFO-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[3-phenyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C=2C=CC=CC=2)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 BZBRIHBDVDUCFO-UHFFFAOYSA-N 0.000 description 6
LGYSSKPTXWNPKH-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[3-phenylmethoxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1OCC=2C=CC=CC=2)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 LGYSSKPTXWNPKH-UHFFFAOYSA-N 0.000 description 6
QJZMAIDVXSIIFK-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[3-phenylmethoxycarbonyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)OCC=2C=CC=CC=2)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 QJZMAIDVXSIIFK-UHFFFAOYSA-N 0.000 description 6
UFYDSTAIJUDNHE-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[3-piperidin-1-yl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1N2CCCCC2)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 UFYDSTAIJUDNHE-UHFFFAOYSA-N 0.000 description 6
FEWGQHYTEGBJFY-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[3-propan-2-yl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 FEWGQHYTEGBJFY-UHFFFAOYSA-N 0.000 description 6
FPDIEXMCHOROPA-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[3-propan-2-yloxy-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1OC(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 FPDIEXMCHOROPA-UHFFFAOYSA-N 0.000 description 6
WEHSHKXBBBYNFJ-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[3-propan-2-yloxycarbonyl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1C(=O)OC(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 WEHSHKXBBBYNFJ-UHFFFAOYSA-N 0.000 description 6
FLFIHJWMQVMSMT-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[3-pyrrolidin-1-yl-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1N2CCCC2)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 FLFIHJWMQVMSMT-UHFFFAOYSA-N 0.000 description 6
VHDOPMHJSBYYHC-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[4-[[2-[3-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=CC(C(F)(F)F)=C1 VHDOPMHJSBYYHC-UHFFFAOYSA-N 0.000 description 6
MPAQJJHEYFQVKF-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 MPAQJJHEYFQVKF-UHFFFAOYSA-N 0.000 description 6
FJYWNJJUAJOEJL-UHFFFAOYSA-N diethyl 2-phenyl-2-[[2-[4-[propan-2-yl-[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1N(C(C)C)C(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 FJYWNJJUAJOEJL-UHFFFAOYSA-N 0.000 description 6
VILOIKMDJRUCLA-UHFFFAOYSA-N diethyl 2-pyridin-2-yl-2-[[2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=NC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 VILOIKMDJRUCLA-UHFFFAOYSA-N 0.000 description 6
UMLUDJUUFTZTNT-UHFFFAOYSA-N diethyl 2-pyridin-3-yl-2-[[2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CN=CC=1C(C(=O)OCC)(C(=O)OCC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 UMLUDJUUFTZTNT-UHFFFAOYSA-N 0.000 description 6
XCLRUDOZRXMGPG-UHFFFAOYSA-N dimethyl 2-[[2-[3-(dimethylcarbamoyl)-4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]-2-phenylpropanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OC)(C(=O)OC)COC(=O)CC(C=C1C(=O)N(C)C)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 XCLRUDOZRXMGPG-UHFFFAOYSA-N 0.000 description 6
MKCRYYQSLDSGEA-UHFFFAOYSA-N dimethyl 2-phenyl-2-[[2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OC)(C(=O)OC)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 MKCRYYQSLDSGEA-UHFFFAOYSA-N 0.000 description 6
GAESNEVCLFYTIY-UHFFFAOYSA-N dipropan-2-yl 2-phenyl-2-[[2-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]phenyl]acetyl]oxymethyl]propanedioate Chemical compound C=1C=CC=CC=1C(C(=O)OC(C)C)(C(=O)OC(C)C)COC(=O)CC(C=C1)=CC=C1NC(=O)C1=CC=CC=C1C1=CC=C(C(F)(F)F)C=C1 GAESNEVCLFYTIY-UHFFFAOYSA-N 0.000 description 6
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