JP4468213B2 - Package for PTP sheet and card-type package including the package - Google Patents

Description

  The present invention relates to a package for packaging a PTP sheet, and more particularly to a package for packaging a PTP sheet, which can provide a strong sealing strength at a relatively low temperature.

  Conventionally, as one medicine packaging technique, press through package (hereinafter simply referred to as “PTP”) packaging is known. For such packaging, a so-called PTP sheet is used, and a medicine is accommodated in the accommodation portion of this sheet, and if necessary, the accommodation portion is pressed to break the aluminum thin film and take out the medicine. This PTP sheet is devised so that information such as characters can be described in order to give a person who administers the drug necessary information such as the type of drug and precautions for taking the drug (for example, Patent Document 1). reference). Further, in order to match the number of medicines contained in the PTP sheet itself with the number of medicines to be taken, seven in the longitudinal direction are provided with a medicine containing part space portion of the number of medicines to be taken in the width direction in one unit. The medicine packaging technique which comprises is also disclosed (for example, refer patent document 2).

  In the above-described medicine packaging, information such as characters is directly written on the PTP sheet. At the stage of medication for known cases, the form of taking the drug is determined to some extent, so even such direct printing was not particularly inconvenient. However, for example, in the case of a drug in the clinical trial stage, since the dosage form is not fixed and it is necessary to convey a wide variety of precautions to the patient, the direct printing as described above is applied to the drug package. It may not be suitable.

Therefore, instead of printing the information directly on the PTP sheet, the PTP sheet is packed in a package that contains the information to ensure various information such as precautions for use, medication history, and symptom notes. There was a request to communicate to patients, doctors, pharmacists and other consumers. Therefore, a card-type package has been proposed in which a PTP sheet containing a medicine is sealed with a package composed of a pair of cardboards describing precautions to take (for example, see Patent Document 3). .
Japanese Utility Model Sho 61-113259 ACT 2-17137 JP-A-10-59415

  However, in the card-type package, when a PTP sheet is packaged and sealed with a pair of cardboards, a thermal paste or the like is attached in advance to the back of the pair of cardboards, and the PTP sheet is sandwiched between the cardboards, A step of heat-sealing the heat-sensitive paste or the like in a pressed state at a certain temperature or higher is necessary. Therefore, there is a possibility that the medicine contained in the PTP sheet is affected by heat at the time of heat sealing and the medicine is deteriorated.

  Therefore, in view of the above circumstances, an object of the present invention is to provide a PTP sheet having a sealing strength that does not break even during distribution or when a patient repeatedly uses it. Another object of the present invention is to provide a package having a sufficient sealing strength even at a lower temperature than in the prior art during heat sealing because it does not affect the drug during heat sealing. Furthermore, another object of the present invention is to provide a package that is not hygroscopic.

  As a result of diligent research on a material for heat sealing when packaging a PTP sheet, the present inventor can heat seal at a relatively low temperature when a resin layer composed of a specific thermoplastic resin combination is employed, and The present invention was completed by obtaining the knowledge that a strong seal strength can be obtained.

  That is, in the first aspect, the present invention is a package including a base material and a heat-sealable thermoplastic resin layer provided on the base material, wherein the resin layer is linear with polyester. A package comprising a low density polyolefin is provided. By combining the heat-sealable thermoplastic resin layer with a specific resin, a strong sealing strength can be realized even at a relatively low temperature.

  In a preferred aspect of the package according to the present invention, the polyester includes polyethylene terephthalate. Among the polyesters, when polyethylene terephthalate is used, sheet strength such as tensile strength after heat sealing is excellent.

  In a preferred aspect of the package according to the present invention, the linear low density polyolefin includes linear low density polyethylene. Among linear low density polyolefins, when linear low density polyethylene is used, sheet strength such as tensile strength after heat sealing is excellent. From the viewpoint of the tensile strength of the package after heat sealing, it is preferable to provide a heat-sealable thermoplastic resin layer in which polyethylene terephthalate and linear low-density polyethylene are laminated in this order on the substrate.

  In a preferred embodiment of the package according to the present invention, the substrate is a synthetic paper containing polyethylene terephthalate or polypropylene. By adopting this synthetic paper, the synthetic paper itself has water resistance, and various information such as various usage precautions, medication history, and symptom notes can be described.

  In a preferred embodiment of the packaging body according to the present invention, the packaging body further comprises a sewing line, and is an opening that penetrates the base material and the resin layer, and is positioned symmetrically with respect to the sewing machine line. It has at least a pair of openings. Through such an opening, the package according to the present invention can receive and package a container for storing a drug in the PTP sheet.

  According to a second aspect, the present invention provides a PTP sheet comprising: a thermoplastic resin layer having at least one housing portion; and a metal thin film that covers an open portion of the housing portion and covers the thermoplastic resin layer. And a base material and a heat-sealable thermoplastic resin layer provided on the base material, wherein the packaging body has a sewing wire and penetrates the base material and the resin layer. And a packaging body having at least a pair of openings positioned symmetrically with respect to the sewing machine line and having an opening for receiving the accommodating portion of the PTP sheet, The heat-sealable thermoplastic resin layer provides a card-type package including polyester and linear low-density polyolefin. In a card-type package in which a PTP sheet is packaged in a package that employs a specific resin combination as a heat-sealable thermoplastic resin layer, a strong sealing strength is realized.

  In a preferred aspect of the card package according to the present invention, the heat-sealable thermoplastic resin layer is bonded by folding the resin layer inward along the sewing line so as to wrap the PTP sheet. With this configuration, a card package having excellent sealing strength even at a relatively low temperature is provided.

Furthermore, in the third aspect, the present invention is a method for producing a card-type package, comprising: (1) a thermoplastic resin layer having at least one housing portion, an open portion of the housing portion, A package comprising a step of preparing a PTP sheet comprising a metal thin film covering a plastic resin layer, or a base material, and a heat-sealable thermoplastic resin layer provided on the base material, The package has a sewing wire, and has at least a pair of openings that pass through the base material and the heat-sealable thermoplastic resin layer and are positioned symmetrically with respect to the sewing wire, and the PTP sheet And (2) preparing the package having an opening for receiving the housing portion, and (2) the heat-sealable heat along the sewing line so that the opening receives the housing portion and wraps the PTP sheet. Plastic resin layer inside A step of bending Ri; applying (3) to adhere the heat-sealable thermoplastic resin layer, heat to the heat-sealable thermoplastic resin layer,
The heat-sealable thermoplastic resin layer provides a production method including polyester and linear low-density polyolefin. By such a manufacturing method, the PTP sheet can be packaged in a package having a strong sealing strength even at a relatively low temperature.

  In the preferable aspect of the manufacturing method which concerns on this invention, the said heat application process is performed at the temperature of 100-300 degreeC, Preferably it is 150-260 degreeC, More preferably, it is 190-230 degreeC. In the manufacturing method according to the present invention, a sealing strength equal to or higher than that of the conventional manufacturing method can be obtained even at a relatively low temperature.

  According to the package according to the present invention, excellent sealing strength can be obtained even at a relatively low temperature, specifically, 300 ° C. or less, and a card-type package in which a PTP sheet is packaged with such a package is provided. .

  Embodiments of the present invention will be described with reference to the drawings. The following embodiment is an example for explaining the present invention, and is not intended to limit the present invention only to this embodiment. The present invention can be implemented in various forms without departing from the gist thereof.

  FIG. 1 is a schematic perspective view of a package 10 according to the present invention. As shown in FIG. 1, the package 10 includes a base material 12 and a heat-sealable thermoplastic resin layer 14 provided on the base material 12. The package 10 has a sewing line 15 and has at least a pair of openings 16 at positions symmetrical to the sewing line 15. In FIG. 1, there are seven pairs of openings as an example, but this can accommodate a PTP sheet having a drug equivalent to one week in the case of a drug taken two tablets a day. Moreover, in the case of a medicine taken once a day, a PTP sheet containing a medicine corresponding to two weeks can be accommodated. The opening 16 is an opening that penetrates the base 12 and the heat-sealable thermoplastic resin layer 14 so as to receive a PTP sheet containing part for containing a medicine.

  Here, as shown in FIG. 2, the PTP sheet 20 is composed of a thermoplastic resin 21 such as polypropylene, and has a structure in which convex-shaped accommodation portions 23 for accommodating medicines are provided in a row. One medicine is accommodated in each accommodating part. The entire surface of the PTP sheet is covered with a metal thin film 22 typified by an aluminum thin film on the surface opposite to the PTP sheet housing. Therefore, the open end (opened on the back surface of the thermoplastic resin) of the accommodating portion 23 is covered with the metal thin film 22. By pressing the container 23 toward the opposite surface, the drug in the container 23 breaks the metal thin film 22, and the drug is released out of the PTP sheet.

  Turning again to FIG. 1, the base material 12 used in the present invention has excellent mechanical, physical, chemical properties, etc., has strength and toughness, and has heat resistance, A resin film or sheet having moisture absorption resistance can be used. Specific examples include polyester resins, polyamide resins, polyaramid resins, polyolefin resins, polycarbonate resins, polystyrene resins, polyacetal resins, fluorine resins, and the like. The resin film or sheet may be any of an unstretched film, a stretched film stretched in a uniaxial direction or a biaxial direction, and the like. Moreover, as the base material 12 used by this invention, the various paper base materials which comprise a paper layer can be used, for example. Specific examples include pure white roll paper, kraft paper, paperboard, and processed paper. Furthermore, as the base material 12 used in the present invention, a synthetic paper having a synthetic polymer as a main component and imparting paper-like properties can be mentioned. Specifically, a synthetic paper containing polypropylene or polyethylene terephthalate, It is preferable from the viewpoint of water resistance. The thickness of the substrate 12 used in the present invention is 50 μm to 500 μm, preferably 100 μm to 300 μm. The surface of the base material 12 used in the present invention may be applied with a desired printing pattern such as a character, a figure, a symbol, a pattern, or a pattern by a normal printing method, as illustrated in FIG. Good. For example, information such as a medicine name, a patient's name, a day of taking, etc. can be written, and a confirmation check for taking can be written.

  The heat-sealable thermoplastic resin layer 14 used in the present invention is a resin film or sheet that can be melted and fused by heat. In particular, even if the heat-sealable thermoplastic resin layer 14 used in the present invention is heat-sealed at a relatively low temperature, strong seal strength can be obtained with respect to tensile strength and the like. The heat-sealable thermoplastic resin layer 14 used in the present invention contains polyester and linear low-density polyolefin. Here, the polyester is a polymer containing a carboxylic acid ester group in the main chain. The polyester used in the present invention includes, as an acid component, an aromatic dicarboxylic acid such as terephthalic acid, isophthalic acid, phthalic acid or naphthalenedicarboxylic acid; an alicyclic dicarboxylic acid such as 1,4-cyclohexanedicarboxylic acid; adipic acid or sebacic acid , Aliphatic dicarboxylic acids such as dodecanedioic acid and eicoic acid; polyfunctional acids such as trimellitic acid and pyromellitic acid; and the like. Examples of alcohol components include ethylene glycol, propylene glycol, 1,4-butanediol, Examples include 1,5-pentanediol, 1,6-hexanediol, neopentthiol glycol, diethylene glycol, 1,4-cyclohexanedimethanol, and the like, and polyesters synthesized from these components. The above polyester can be used as a homopolymer or a copolymer. It is also possible to use a blend of two or more homopolymers and / or copolymerized polymers. Examples of the homopolymer include polyethylene terephthalate, polytrimethylene terephthalate, polybutylene terephthalate, polyhexamethylene terephthalate, polypentamethylene terephthalate, polyethylene-2,6-naphthalate, polylactic acid, and the like. The polyester used in the present invention is preferably polyethylene terephthalate using terephthalic acid as the acid component and ethylene glycol as the alcohol component.

  The linear low-density polyolefin used in the present invention is a low-density polyolefin among polyolefins divided into high-density and low-density polyolefin due to the difference in molecular structure, and the main chain is linear. . Specific examples of the linear low density polyolefin include linear low density polyethylene. The linear low density polyethylene used in the present invention may be an ethylene homopolymer or a copolymer of ethylene and an α-olefin having 3 to 10 carbon atoms. The copolymer of ethylene and α-olefin may be a random copolymer or a block copolymer. Examples of the α-olefin having 3 to 10 carbon atoms include propylene, 1-butene, 1-pentene, 1-hexene, 4-methyl-1-pentene, 1-heptene, 1-octene, 1-nonene, 1 -Decene etc. are mentioned, 1 type of these alpha olefins may be sufficient, and 2 or more types may be used together.

The density of the linear low density polyethylene used in the present invention is in the range of 0.918 g / cm ^{3 to} 0.940 g / cm ³ . When high density polyethylene having a density of 0.941 g / cm ³ or more is used, rigidity, tensile strength, and heat resistance are improved, but impact strength, crack resistance, tear strength, transparency, and low temperature sealing properties are lowered.

  Furthermore, the heat-sealable thermoplastic resin layer 14 used in the present invention can be formed by laminating polyester / linear low-density polyolefin on the base material 12 or by coating as described later. The thickness of the heat-sealable thermoplastic resin layer 14 is 70 μm to 600 μm, preferably 100 μm to 400 μm, and more preferably 130 to 360 μm. The heat-sealable thermoplastic resin layer 14 can be laminated on the substrate 12 by dry lamination.

  On the other hand, the method of applying the heat-sealable thermoplastic resin layer 14 used in the present invention to the substrate 12 is to add any additive to the polyester / linear low density polyolefin of the present invention and dissolve in a solvent. A coating composition such as a roll coating method, a gravure coating method, a spray coating method, an air knife coating method, a kiss coating method or the like is used. Further, the resin layer 14 can be coated on the base material 12 by extruding and coating the heat-sealable thermoplastic resin layer 14 on the base material 12.

  FIG. 3 is a schematic front view showing one embodiment of the package 10 according to the present invention. The base material 12 that constitutes the package 10 describes precautions and the like that are comparatively detailed necessary for the clinical trial stage. Patients who receive such medication can take the drug with reference to this relatively detailed consideration. Note that the package 10 illustrated in FIG. 3 also contains a drug for one week.

  FIG. 4 shows an exploded perspective view of a card-type package 30 including a package 10 according to the present invention and a PTP sheet 20 packaged by the package 10. As shown in FIG. 4, the card-type package 30 has a structure in which a PTP sheet 20 containing a medicine is packaged between the packages 10 according to the present invention, which are rectangular as a whole. The PTP sheet 20 is disposed so as to be wrapped with the resin layer 14 with the heat-sealable thermoplastic resin layer 14 of the package 10 according to the present invention as an inner side. Next, the accommodating portion 23 of the PTP sheet 20 is received in the opening portion 16 of the package 10, and an opening portion that is paired with the opening portion 16 is disposed on the opposite surface of the accommodating portion 23. Thereafter, the package 10 is bent along the sewing machine line 15, and heat is applied to the package 10 so that there is no thermal influence on the medicine accommodated in the PTP sheet 10, and the heat-sealable thermoplastic resin layer 14 is formed. Adhere. In this way, the PTP sheet 20 can be packaged by the package 10 according to the present invention. The packaged card-type package 30 has a sealing strength having a large tensile strength even at a relatively low temperature, for example, 190 ° C., due to the heat-sealable thermoplastic resin layer 14 according to the present invention. There is almost no thermal effect on the drug.

  FIG. 5 is a schematic side view of the card-type package 30 according to the present invention. As described above, the PTP sheet 20 can be packaged by bonding the heat-sealable thermoplastic resin layer 14 of the package 10 according to the present invention by heat. When the drug is administered, the container 23 can be pressed with a human finger or the like from above, the aluminum thin film 22 can be broken, and the drug can be taken out.

  FIG. 6 is a process diagram illustrating a method for manufacturing the card-type package 30 according to the present invention. As shown in FIG. 6, first, a PTP sheet 20 is prepared (see step S10). The configuration of the PTP sheet 20 is the same as that described with reference to FIG. Next, in step S11, the package 10 according to the present invention is prepared. The configuration of the package 10 is the same as that described with reference to FIG. In the description of FIG. 6, the step of preparing the PTP sheet 20 is performed first, but the step of preparing the package 10 according to the present invention may be performed first.

  In this manner, after preparing the PTP sheet 20 and the package 10 in advance in Step S10 and Step S11, in Step S12, the heat sealable thermoplastic resin layer 14 of the package 10 is set as the inner side, The PTP sheet 20 is disposed in the inner region. The packaging body 10 is folded along the sewing machine line 15 of the packaging body 10 so as to wrap the PTP sheet 20 with the heat-sealable thermoplastic resin layer 14 as an inner side. At the time of this folding, one of the pair of openings 16 of the package 10 is folded so as to receive the accommodating portion 23 of the PTP sheet 20. Further, the other of the pair of openings 16 is bent so as to be positioned directly below the open part facing the accommodation part 23 of the PTP sheet 20. By doing so, it becomes the structure where the accommodating part 23 of a PTP sheet protrudes from the package 10, and a chemical | medical agent can be taken out by pressing this protruding accommodating part 23 at the time of chemical | medical agent use.

  After step 12, the package 10 according to the present invention that wraps the PTP sheet 20 is applied with heat in a pressed state, so-called heat-sealing, so that the card-type package 30 including the package 10 in which the PTP sheet 20 is packaged. Is completed. This melts when the heat-sealable thermoplastic resin layer 14 is heated in a pressed state at a certain temperature or higher, and the resin layers are bonded and integrated. As temperature of the heat applied to the package 10 by this invention, it is 100 to 300 degreeC, Preferably it is 150 to 260 degreeC, More preferably, it is 190 to 230 degreeC. In addition, when applying heat, it is necessary to avoid the contact between the storage unit storing the medicine and the heat source. Further, the method of applying heat is not limited to the following, but the card package 30 is placed on an appropriate base and a heating source such as a heater is pressed from above the card package 30. Thus, the resin layers 14 can be heat sealed. Further, there may be mentioned a method in which a pressure sensitive adhesive such as hot melt is sequentially applied to the bonding side, a PTP sheet is sandwiched in the card, and the inner surfaces of the card package are pressed and bonded together. As a specific apparatus for performing the heat sealing in the present invention, a card sealing machine (Nagura Automatic Foil Stamping Machine 600S manufactured by Nagakura Machine Industry Co., Ltd.) can be exemplified. The pressure, heating time, and the like as conditions in the application of heat are appropriately adjusted according to the thickness, material, area, and structure of the card sealing machine, the heat capacity of the heating plate, the area of the heating plate, etc. The pressure is 0.4 to 0.6 MPa, preferably 0.45 to 0.55 MPa, and the heating time is 1 to 5 seconds, preferably 2 to 4 seconds.

  The present invention will be described in more detail with reference to the following examples, but the scope of the present invention is not limited thereto. Various changes and modifications can be made by those skilled in the art based on the description of the present invention, and these changes and modifications are also included in the present invention.

Polyethylene terephthalate resin (thickness: 250 μm; trade name “Crisper”: manufactured by Toyobo Co., Ltd.) as a base material, including Examples 1 and Comparative Examples 1 to 4, the following five types of heat sealing heat The plastic resin layer was formed using an FL2 dry laminator manufactured by Fuji Machine Industry Co., Ltd.
Example 1
(1) Polyethylene terephthalate (Toray Industries, Inc .: trade name “Lumirror T60”) 12 μm and linear low density polyethylene (20 μm) (Idemitsu Kosan Co., Ltd .: trade name “MORETECH 0138”) In order.
(Comparative Example 1)
(2) Biaxially stretched polypropylene 20 μm (Idemitsu Kosan Co., Ltd .: trade name “IDEMITSU PP F-200S”) and the aforementioned linear low-density polyethylene (20 μm) were sequentially provided on the base material.
(Comparative Example 2)
(3) Polyethylene terephthalate 12 μm and polyethylene (20 μm) (Mitsui Chemicals, Inc .: trade name “Mirason 10P”) were sequentially provided on the base material.
(Comparative Example 3)
(4) The above-mentioned biaxially stretched polypropylene (20 μm) and the above-mentioned polyethylene (20 μm) were sequentially provided on the substrate.
(Comparative Example 4)
(5) Polyethylene terephthalate (Asahi Kasei Suntech LP L1850A) 12 μm and the above-mentioned polyethylene (20 μm) were sequentially provided on the substrate.

  Using a card sealing machine (Nagura Machinery Industrial Co., Ltd. Nagakura Automatic Foil Stamping Machine 600S), the package prepared in this way is set to a mechanical pressure of 0.49 MPa ± 0.1 MPa, and in the range of 190 ° C. to 230 ° C. The heat-sealable thermoplastic resin layer was adhered at a temperature changed by 10 ° C. The tensile strength was measured using a tensile tester (Strograph V1-C manufactured by Toyo Seiki Seisakusho Co., Ltd.). In the measurement, a heat-sealed card-type package is bent so that a test piece cut at a width of 15 mm can be easily set on the chuck portion of the strograph. The tensile strength was measured by moving the crosshead at a tensile speed of 50 mm / min. In addition, five packaging bodies were produced for each packaging body, and the average was taken as the value of the tensile strength of each packaging body.

  FIG. 7 is a diagram showing the results when the temperature conditions are changed for the tensile strength of the packaging bodies according to the examples and comparative examples of the present invention. From the result shown in FIG. 7, in the package in the present invention, the heat-sealable thermoplastic resin layer composed of polyethylene terephthalate and linear low-density polyethylene as an example of the present invention has a temperature of 190 ° C. to 230 ° C. In range, the value of tensile strength is large as compared with other heat-sealable thermoplastic resin layers which are comparative examples of the present invention. Further, when a heat-sealable thermoplastic resin layer composed of polyethylene terephthalate and linear low-density polyethylene according to the present invention is used, a package that exhibits a tensile strength of 30 N or more when heat-sealed at a temperature of 200 ° C. or higher. was gotten.

FIG. 1 is a schematic perspective view of a package 10 according to the present invention. FIG. 2 is a schematic perspective view of the PTP sheet. FIG. 3 is a schematic front view showing one embodiment of the package 10 according to the present invention. FIG. 4 shows an exploded perspective view of a card-type package 30 including a package 10 according to the present invention and a PTP sheet 20 packaged by the package 10. FIG. 5 is a schematic side view of the card-type package 30 according to the present invention. FIG. 6 is a process diagram illustrating a method for manufacturing the card-type package 30 according to the present invention. FIG. 7 is a diagram showing the results of the tensile strength of the packages according to the examples and comparative examples of the present invention. In the figure, PET represents polyethylene terephthalate, LLDPE represents linear low density polyethylene, OPP represents biaxially oriented polypropylene, and PE represents polyethylene.

Explanation of symbols

DESCRIPTION OF SYMBOLS 10 ... Package by this invention, 12 ... Base material, 14 ... Heat sealable thermoplastic resin layer, 15 ... Sewing machine line, 16 ... Opening part, 20 ... PTP sheet, 21 ... Thermoplastic resin, 22 ... Metal thin film, 23 ... Storage part, 30 ... Card package

Claims (8)

A package comprising a base material and a heat-sealable thermoplastic resin layer provided on the base material,
The heat-sealable thermoplastic resin layer is viewed contains a polyester and a linear low density polyolefin,
A packaging body further comprising a sewing line, and having at least a pair of openings, which are openings that pass through the base material and the resin layer, and are positioned symmetrically with respect to the sewing line .   The package according to claim 1, wherein the polyester includes polyethylene terephthalate.   The package according to claim 1 or 2, wherein the linear low-density polyolefin includes linear low-density polyethylene.   The package according to any one of claims 1 to 3, wherein the base material is a synthetic paper containing polyethylene terephthalate or polypropylene. A PTP sheet comprising: a thermoplastic resin layer having at least one housing portion; and a metal thin film covering the open portion of the housing portion and covering the thermoplastic resin layer;
A packaging body comprising a base material and a heat-sealable thermoplastic resin layer provided on the base material, the packaging body having a sewing line, penetrating the base material and the resin layer, A card-type package comprising: a package having at least a pair of openings positioned symmetrically with respect to the sewing machine line and having an opening for receiving the accommodating portion of the PTP sheet;
The heat-sealable thermoplastic resin layer is a card-type package including polyester and linear low-density polyolefin. 6. The card-type package according to claim 5 , wherein the package is configured to bend the resin layer inward along the sewing line so as to wrap the PTP sheet, and to adhere the heat-sealable thermoplastic resin layer. A method for producing a card-type package,
(1) A step of preparing a PTP sheet comprising a thermoplastic resin layer having at least one housing part and a metal thin film covering the open part of the housing part and covering the thermoplastic resin layer, or
A package comprising a substrate and a heat-sealable thermoplastic resin layer provided on the substrate, wherein the package has a sewing wire, and the substrate and the heat-sealable thermoplastic resin layer And preparing a package having an opening that receives at least a pair of openings and that receives an accommodation part of the PTP sheet, and is positioned symmetrically with respect to the sewing machine line.
(2) a step of bending the heat-sealable thermoplastic resin layer inward along the sewing line so that the opening receives the accommodating portion and wraps the PTP sheet;
(3) applying heat to the heat-sealable thermoplastic resin layer so as to adhere the heat-sealable thermoplastic resin layer;
Including
The said heat-sealable thermoplastic resin layer is a manufacturing method containing polyester and linear low density polyolefin. The said heat application process is a manufacturing method of Claim 7 performed at 100-300 degreeC.

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