JP4422018B2 - ミセルアセンブリ - Google Patents

ミセルアセンブリ Download PDF

Info

Publication number
JP4422018B2
JP4422018B2 JP2004510715A JP2004510715A JP4422018B2 JP 4422018 B2 JP4422018 B2 JP 4422018B2 JP 2004510715 A JP2004510715 A JP 2004510715A JP 2004510715 A JP2004510715 A JP 2004510715A JP 4422018 B2 JP4422018 B2 JP 4422018B2
Authority
JP
Japan
Prior art keywords
formula
compound
acid
compounds
solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2004510715A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006509050A (ja
JP2006509050A5 (https=
Inventor
キャサリン イー． ユーリッチ，
ルー ティアン，
Original Assignee
ラトガーズ， ザ ステート ユニバーシティー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ラトガーズ， ザ ステート ユニバーシティー filed Critical ラトガーズ， ザ ステート ユニバーシティー
Publication of JP2006509050A publication Critical patent/JP2006509050A/ja
Publication of JP2006509050A5 publication Critical patent/JP2006509050A5/ja
Application granted granted Critical
Publication of JP4422018B2 publication Critical patent/JP4422018B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F283/00—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G
    • C08F283/06—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G on to polyethers, polyoxymethylenes or polyacetals
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
    • C08F290/02—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated end groups
    • C08F290/06—Polymers provided for in subclass C08G
    • C08F290/062—Polyethers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
    • C08F290/08—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated side groups
    • C08F290/14—Polymers provided for in subclass C08G
    • C08F290/142—Polyethers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nanotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyethers (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
JP2004510715A 2002-06-07 2003-06-06 ミセルアセンブリ Expired - Fee Related JP4422018B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38692002P 2002-06-07 2002-06-07
PCT/US2003/017902 WO2003103594A2 (en) 2002-06-07 2003-06-06 Micelle assemblies

Publications (3)

Publication Number Publication Date
JP2006509050A JP2006509050A (ja) 2006-03-16
JP2006509050A5 JP2006509050A5 (https=) 2006-07-13
JP4422018B2 true JP4422018B2 (ja) 2010-02-24

Family

ID=29736231

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004510715A Expired - Fee Related JP4422018B2 (ja) 2002-06-07 2003-06-06 ミセルアセンブリ

Country Status (8)

Country Link
US (2) US7470802B2 (https=)
EP (1) EP1531835B1 (https=)
JP (1) JP4422018B2 (https=)
CN (1) CN1735418A (https=)
AU (1) AU2003238929A1 (https=)
CA (1) CA2488121C (https=)
MX (1) MXPA04012290A (https=)
WO (1) WO2003103594A2 (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6486214B1 (en) * 1997-09-10 2002-11-26 Rutgers, The State University Of New Jersey Polyanhydride linkers for production of drug polymers and drug polymer compositions produced thereby
US20040038948A1 (en) 1999-12-07 2004-02-26 Uhrich Kathryn E. Therapeutic compositions and methods
WO2005074887A2 (en) 2004-01-30 2005-08-18 Rutgers, The State University Amphiphilic star-like or scorpion-like macromolecules, various compositions and uses thereof
US7901705B2 (en) * 2006-02-28 2011-03-08 Tyco Healthcare Group Lp Antimicrobial releasing polymers
US20110008396A1 (en) * 2007-09-20 2011-01-13 Rutgers, The Sate University Of New Jersey Compositions and methods for treating cardiovascular conditions
CA2638240C (en) 2008-08-29 2010-02-02 Alexander Macgregor Method of treating dysglycemia and glucose excursions
US8790621B2 (en) * 2010-04-12 2014-07-29 Iowa State University Research Foundation, Inc. Nanoparticles and nanoparticle compositions
US20120219598A1 (en) * 2011-02-22 2012-08-30 Uhrich Kathryn E Polymeric micelles for reducing ldl in vivo
US8846850B2 (en) 2011-02-22 2014-09-30 Rutgers, The State University Of New Jersey Amphiphilic macromolecules for nucleic acid delivery
US9434681B2 (en) 2012-06-15 2016-09-06 Rutgers, The State University Of New Jersey Macromolecules for treating atherosclerosis
US9144579B2 (en) 2012-08-17 2015-09-29 Rutgers, The State University Of New Jersey Polyesters and methods of use thereof
US20140120057A1 (en) 2012-10-25 2014-05-01 Rutgers, The State University Of New Jersey Polymers and methods thereof for wound healing
US9387250B2 (en) 2013-03-15 2016-07-12 Rutgers, The State University Of New Jersey Therapeutic compositions for bone repair
WO2014194055A1 (en) 2013-05-29 2014-12-04 Rutgers, The State University Of New Jersey Antioxidant-based poly(anhydride-esters)
US10023521B2 (en) 2014-06-13 2018-07-17 Rutgers, The State University Of New Jersey Process and intermediates for preparing poly(anhydride-esters)
WO2015195563A1 (en) 2014-06-16 2015-12-23 Rutgers, The State University Of New Jersey Antibacterial agents
US9630905B2 (en) 2014-09-08 2017-04-25 Rutgers, The State University Of New Jersey Amphiphilic macromolecules and methods of use thereof
WO2016164898A1 (en) 2015-04-10 2016-10-13 Rutgers, The State University Of New Jersey Kojic acid polymers
US10759740B2 (en) 2016-03-24 2020-09-01 Rutgers, The State University Of New Jersey Antibacterial agents
EP3494199A1 (en) 2016-08-05 2019-06-12 Rutgers, the State University of New Jersey Thermocleavable friction modifiers and methods thereof
US10744079B2 (en) 2017-08-23 2020-08-18 Colgate-Palmolive Company Oral care compositions and uses thereof
CN113750918B (zh) * 2021-08-17 2022-06-17 常州大学 一种基于小分子非共价后修饰制备补丁状各向异性球状胶束的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4065598A (en) * 1975-03-17 1977-12-27 Toray Industries, Inc. Process for polymeric modification of a fiber
JP3070622B2 (ja) 1991-04-25 2000-07-31 川崎製鉄株式会社 プログラマブル論理素子
AU3931093A (en) * 1993-03-19 1994-10-11 Handelman, Joseph H. Topical composition for inhibiting hair growth
US6328988B1 (en) 1999-04-23 2001-12-11 Rutgers, The State University Of New Jersey Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules
US6365146B1 (en) * 1999-04-23 2002-04-02 Rutgers, The State University Of New Jersey Polymer encapsulation of hydrophobic materials
DK1198490T3 (da) 1999-07-14 2006-06-19 Alza Corp Neutral lipopolymer og liposomsammensætninger indeholdende samme
EP1414784A2 (en) * 2001-07-12 2004-05-06 Rutgers, The State University Of New Jersey Amphiphilic star-like macromolecules for drug delivery
US7141540B2 (en) 2001-11-30 2006-11-28 Genta Salus Llc Cyclodextrin grafted biocompatible amphilphilic polymer and methods of preparation and use thereof

Also Published As

Publication number Publication date
US8192754B2 (en) 2012-06-05
JP2006509050A (ja) 2006-03-16
US20060039964A1 (en) 2006-02-23
AU2003238929A1 (en) 2003-12-22
WO2003103594A3 (en) 2004-04-22
EP1531835B1 (en) 2013-08-07
EP1531835A2 (en) 2005-05-25
CN1735418A (zh) 2006-02-15
EP1531835A4 (en) 2006-12-13
US20090175932A1 (en) 2009-07-09
MXPA04012290A (es) 2005-04-08
CA2488121A1 (en) 2003-12-18
WO2003103594A2 (en) 2003-12-18
US7470802B2 (en) 2008-12-30
CA2488121C (en) 2012-07-24

Similar Documents

Publication Publication Date Title
JP4422018B2 (ja) ミセルアセンブリ
US6328988B1 (en) Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules
US7262221B2 (en) Amphiphilic star-like macromolecules for drug delivery
US6365146B1 (en) Polymer encapsulation of hydrophobic materials
JP4078300B2 (ja) 薬剤送達媒体としてのマルチアームブロック共重合体
JP2009527581A (ja) 分割型の分解性重合体とそれから生成される複合体
US20120219598A1 (en) Polymeric micelles for reducing ldl in vivo
EP2861558B1 (en) Macromolecules for treating atherosclerosis
JPH07173079A (ja) 両親媒性ポリエチレングリコール誘導体および用途
KR20050024317A (ko) 미셀 조립체
JPH07242680A (ja) 反応性小胞体、形成剤および機能性物質固定化小胞体
AU2002337650A1 (en) Amphiphilic star-like macromolecules for drug delivery
CN1729156A (zh) 用于药物释放的两亲性星形大分子
JP3590983B2 (ja) リン脂質誘導体
HK1209411B (en) Macromolecules for treating atherosclerosis

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20060524

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20060524

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20090324

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090408

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20090707

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20090714

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20090805

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20090812

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20090907

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20090914

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20091008

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20091008

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20091117

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20091203

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20121211

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20131211

Year of fee payment: 4

LAPS Cancellation because of no payment of annual fees