JP4359205B2 - Skin moisturizing food - Google Patents

Description

  The present invention relates to a food containing sugar ceramide and diacylglycerol.

  The stratum corneum of the skin has a barrier function that prevents transpiration of moisture from the body and prevents irritation from the outside world. It is known that when this barrier function is impaired by ultraviolet rays, surfactants, drying, mechanical stimulation, active oxygen, residual chlorine in tap water, etc., it induces dry skin, atopic dermatitis, skin roughness, etc. Yes.

  Ceramide, which consists of fatty acid and sphingosine, and cerebroside, which consists of sugar, fatty acid, and sphingosine, are abundant in the stratum corneum of human skin, and are thought to function to prevent water from evaporating from the body. Therefore, attempts have been made to improve the amount of keratinous moisture in the skin by administering ceramide or glycosphingolipid.

  For example, it is reported that the moisture retention function of the skin is improved by ingesting ceramide (for example, see Non-Patent Document 1), and it is reported that the skin is beautiful and exhibits a beauty effect (for example, Patent Document) 1). Furthermore, it has been reported that when glycosphingolipids are orally ingested together with plant sterols, they are efficiently absorbed and exhibit excellent effects in improving the amount of keratin water in the skin and improving rough skin (for example, see Patent Document 2).

On the other hand, diacylglycerol has an action to suppress the increase in blood neutral fat after meal (for example, see Patent Document 2) and an action to increase blood HDL cholesterol (for example, see Patent Document 3). Used in processed oil and fat foods.
However, no food containing diacylglycerol and sugar ceramide has been known so far.
JP-A-11-113530 JP 2003-2835 A JP 2001-64170 A Fragrance Journal, 23 (1), 81 (1995)

  The present invention provides a food that has an excellent skin barrier function-improving action and exhibits a moisturizing effect when taken orally.

  The inventors of the present invention have studied ingredients that exhibit a superior skin moisturizing effect by oral ingestion. When both saccharide ceramide and diacylglycerol are ingested, the horny layer is compared to when saccharide ceramide is ingested alone. It has been found that the amount of ceramide is increased, and the skin barrier function and keratin moisture retention function are greatly improved.

  That is, the present invention provides a food containing sugar ceramide and diacylglycerol.

  According to the food of the present invention, it is possible to easily improve and strengthen the barrier function of the whole body skin and increase the moisture content of the skin.

Examples of the sugar ceramide in the present invention include glucosyl ceramide, galactosyl ceramide, etc. Among them, glucosyl ceramide is preferable.
Such sugar ceramide can be obtained by extraction from tissues of mammals such as cows and horses, extraction from rice bran or the like, or chemical synthesis. For example, glycosylceramides include rice (Agric. Biol. Chem., 49, 2753 (1985)), rice bran (JP 62-187404 A, JP 11-279586 A), wheat (Agric. Biol. Chem). , 49, 3609 (1985), JP 6-507653 A), soybean (Chem. Pharm. Bull., 38 (11), 2933 (1990), JP 7-2683 A), konjac rice ( Japanese Patent Application Laid-Open No. 2003-2835) and the like.
Moreover, commercially available nip n ceramide (manufactured by Nippon Flour), oryzah ceramide (manufactured by Oriza oil), Nissan ceramide (manufactured by Nippon Oil & Fats), ceramide (manufactured by Unitika) and the like can be used.

  As the diacylglycerol used in the food of the present invention, the constituent fatty acid is an acyl group having 8 to 24 carbon atoms, particularly 12 to 22 carbon atoms such as palmitic acid, stearic acid, oleic acid, linoleic acid, eicosapentaenoic acid, docosahexaenoic acid. Those having an acyl group derived therefrom are preferred. The amount of unsaturated acyl groups in diacylglycerol is preferably 55% by weight (hereinafter simply expressed as%) or more, particularly 70% or more of the total amount of acyl groups. The unsaturated fatty acid is most preferably composed of 15 to 85% oleic acid and 15 to 85% linoleic acid.

  Diacylglycerol is a method described in JP-A-4-30025, for example, glyceride oil, soybean oil, rice bran oil, corn oil, palm oil, olive oil, perilla oil, sesame oil, egg oil, linseed oil, fish oil, and other triglycerides. It can be obtained by any method such as an ester exchange reaction between oil and glycerin, or an esterification reaction between fatty acid derived from fat and oil and glycerin. Examples of the reaction method include a chemical reaction method using an alkali catalyst and the like, a biochemical reaction method using an oil and fat hydrolase such as lipase, and the like. From the viewpoint of appearance, a biochemical reaction method is preferable.

  Such a diacylglycerol itself does not have a skin barrier function or a keratin water content retaining function, but increases the amount of horny layer ceramide when mixed with sugar ceramide in food, resulting in extremely excellent skin. (Example 2).

The mixing ratio of sugar ceramide and diacylglycerol contained in the food of the present invention is preferably 100: 1 to 1: 10000, more preferably 10: 1 to 1: 100, by weight.
The blending amount is preferably 0.01 to 20%, more preferably 0.1 to 10%.

  The food of the present invention includes, for example, the above-mentioned sugar ceramide as a food ingredient such as sweeteners, coloring agents, antioxidants, vitamins, flavorings, minerals, etc., proteins, lipids, carbohydrates, carbohydrates, dietary fibers, etc. And diacylglycerol can be mixed to prepare various food forms according to a conventional method.

  Examples of food forms include drinks such as drinks, powdered drinks such as powdered juice, confectionery such as candy, drop, jelly, cookies, chocolate, cake, yogurt, gum, seasonings, cooking oil, dairy products, bread And processed rice. Moreover, it is good also as beauty foods, health foods, etc., such as a tablet (tablet), a capsule, and a granule. Moreover, it is good also as food for pets, such as a dog, a cat, and a hamster.

  The intake of the food of the present invention is appropriately selected depending on the form of the food, the age of the user, sex, and other conditions, but is usually about 0.1 μg to 2 mg, preferably 2 μg per kg of body weight per day as sugar ceramide. It is good to be about ~ 400 μg, and it can be taken once a day or divided into 2 to 4 times.

As shown in the Examples below, the food of the present invention increases the amount of horny layer ceramide and significantly improves the skin barrier function and the keratin moisture retention function as compared with the case where sugar ceramide is ingested alone. Therefore, by ingesting the food, the barrier function of the skin is improved or improved, a moisturizing effect is obtained, prevention / improvement of dry skin, prevention / improvement of rough skin due to drying, prevention / improvement of atopic dermatitis Can be planned.
That is, the food of the present invention is a food for improving the barrier function of the skin, improvement of skin moisture retention, prevention / improvement of dryness, prevention / improvement of rough skin, beauty for prevention / improvement of atopic dermatitis It can be used as various foods such as foods and health foods.

Example 1 Production of a Sugar Ceramide-Containing Food A sugar ceramide-containing food having the composition shown in Table 1 was produced.
Niphunceramide (manufactured by Nippon Flour), diacylglycerol (DAG: manufactured by Kao), casein, DL-methionine, corn starch, pregelatinized corn starch, sucrose, cellulose powder, corn oil, AIN-76 mineral mixture, AIN-76A vitamin After mixing and heating and mixing with choline bitartrate (above, manufactured by Oriental Yeast), the mixture was extruded and dried to produce Product 1 of the present invention. Further, Comparative Product 1 was prepared in the same manner except for diacylglycerol, and a control food was prepared in the same manner except for diacylglycerol and nipinceramide.

Example 2 Skin barrier function improving effect, stratum corneum water content increasing effect, ceramide water content increasing effect HR1 mice, 6 weeks old, sputum, and a basic diet (AIN-76A combination: solid sample) as a preliminary breeding for 1 week before the start of the experiment Free water consumption. Grouping was performed according to body weight (8 animals in each group), and after starting the administration of the test meal shown in Table 1, the animals were reared for another 5 weeks.
1) Skin barrier recovery rate:
Nichiban PPS tape was applied and peeled off to the same part of the mouse skin where the initial TEWL value (transepidermal water loss) was measured with a hydrometer (MEECO) 5 times (hereinafter referred to as tape stripping). The recovery rate of each group was determined from the TEWL value and the TEWL value after 2 hours.
2) Water content of stratum corneum:
Measured with SKICON-200 (IBS).
3) Amount of ceramide (amount of ceramide per 1 mg of stratum corneum):
Mice (8 per group) that had been ingested for 8 weeks with each compounded food were peeled and the dorsal skin was peeled off and heated in a 60 ° C. water bath for 1 minute before ingesting the epidermis. Immediately, it was treated in a trypsin solution at 37 ° C. for 1 hour to obtain a stratum corneum. After lyophilization, the stratum corneum weight was measured, and the lipid was measured by the Blibh and Dyer method ("Biochemical Experimental Method 9 Introduction to Lipid and Lipid Oxide Analysis" edited by Yasuo Miyazawa and Yasuo Fujino, p45, revised on January 30, 2000) Was extracted, and the amount of ceramide was determined by the TLC method.
The results are shown in Table 2.

  As a result, the administration group of Comparative Product 1 containing saccharide ceramide is less effective in increasing the stratum corneum moisture content and improving the barrier recovery ability than the control administration group, whereas the saccharide ceramide and diacylglycerol are used in combination. In the administration group of Invention Product 1, the amount of horny layer ceramide was increased, and both the stratum corneum water amount increasing action and the barrier recovery promoting action were remarkably recognized.

Claims (3)

  A food containing sugar ceramide and diacylglycerol.   The food according to claim 1, which is a food for improving the skin barrier function.   The food according to claim 1, which is a skin moisturizing food.