JP4330555B2 - Artificial blood vessel manufacturing method - Google Patents

Description

The present invention relates to a method for producing an artificial blood vessel having physical properties approximate to the biological vessel.

Currently, in the clinic, artificial blood vessels made of artificial materials are widely used as substitute blood vessels to replace pathologically deteriorated blood vessels. In such artificial blood vessels, various proposals have been made to satisfy the requirements as substitute blood vessels such as non-toxicity, durability and antithrombotic properties. For example, in Patent Document 1, in order to satisfy the durability and easiness of suturing included in the necessary conditions as a substitute blood vessel, a plurality of layered materials in which a plurality of collagen filaments are arranged substantially in parallel are stacked at a predetermined angle and bonded. An artificial blood vessel has been proposed in which the collagen non-woven fabric is molded into a tubular shape.
JP 2004-188037 A

  However, the conventional artificial blood vessels represented by the above-mentioned proposals are manufactured through a complicated process, so that the manufacturing cost cannot be suppressed, and the resulting artificial blood vessel becomes expensive. There is.

  In addition, in such an artificial blood vessel application, it is needless to say that it is important to use in the above-mentioned clinical practice, but in order to acquire the surgical technique in a pre-clinical stage that may damage the human body. It is also extremely important to use it for education and practice. In such an artificial blood vessel for education and practice, when using an expensive artificial blood vessel as described above, the burden on the user becomes extremely large, which may be a hindrance when sufficiently acquiring a surgical technique. There is.

The present invention has been made in view of such conventional problems, and can be manufactured inexpensively without going through a complicated process, and has excellent elasticity and extensibility included in the necessary conditions as a substitute blood vessel. It aims at providing the manufacturing method of the blood vessel.

In order to solve the above-mentioned problems, the present invention includes (a) a step of inserting a conductive rod-like body into a tubular body made of fibrous material, and (b) adding a lubricating oil to the powdery body of thermoplastic elastomer and stirring. A step of immersing the gel-like substance generated in the tubular body into which the rod-shaped body is inserted for a certain time; (c) a step of pulling out the tubular body into which the rod-shaped body is inserted; and (d) the rod-shaped body. And (e) pulling out the rod-like body from the tubular body, and dissolving the gel-like substance around the rod-like body by passing a current through the tube body and drying the gel-like substance permeating the tubular body for a certain period of time. And a process for producing an artificial blood vessel. As a result, the present invention has made it possible to inexpensively manufacture an artificial blood vessel suitable for surgical practice that is excellent in elasticity and extensibility that approximates a biological blood vessel.

  In particular, in the method for producing an artificial blood vessel according to the present invention, the surface of the artificial blood vessel is constructed by infiltrating the tubular body with a gel substance generated by adding a certain ratio of a solvent to the thermoplastic material. ing. This makes it possible to generate an artificial blood vessel of uniform thickness by effectively utilizing the time until curing, unlike a substance that is dissolved by heat, and it is possible to improve workability in the manufacturing process. Become.

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Furthermore, in the method for producing an artificial blood vessel according to the present invention, the lubricating oil is added to a first powdery material obtained by pulverizing the thermoplastic material with the powdery material composed of the thermoplastic elastomer. The second intermediate powder having a larger particle diameter than the first powder, obtained by pulverizing the powder intermediate composed of the first intermediate produced and the thermoplastic elastomer into fine particles. You may make it produce | generate by stirring the 2nd intermediate body produced | generated by adding lubricating oil. In this case, for example, in the first intermediate body, the elasticity imparted to the artificial blood vessel can be changed by changing the ratio of the lubricating oil to the first powdery body. Moreover, since the 2nd intermediate body produced | generated from the 2nd powdery body with a particle size larger than a 1st powdery body is stirred with the 1st intermediate body, the thermoplastic material is produced | generated, When an incision is made with a scalpel or the like, it is possible to provide an artificial blood vessel having a feeling of incision similar to a biological blood vessel.

  In the method for manufacturing an artificial blood vessel according to the present invention, both ends of the tubular body are fixed to the rod-like body with the gel-like substance before the tubular body into which the rod-like body is inserted is immersed in a predetermined gel-like substance. I have to. As a result, the tubular body attached to the rod-shaped body is prevented from being displaced from a certain position, so that the gel-like substance can be evenly attached to the tubular body.

  Further, in the method for manufacturing an artificial blood vessel according to the present invention, the rod-shaped body is made of a conductive metal, and before the rod-shaped body is pulled out from the tubular body, an electric current is passed through the rod-shaped body to form a gel around the rod-shaped body. Dissolve the substance. This makes it easy to pull out the rod-like body. Moreover, since the inner surface of the artificial blood vessel corresponding to the inner wall of the biological blood vessel can be smoothed, the inner surface can also have a shape that approximates the biological blood vessel.

  Further, in the method for manufacturing an artificial blood vessel according to the present invention, the step of taking out the tubular body into which the rod-like body has been inserted after immersing it in a predetermined gel substance for a certain period of time, and drying the gel substance permeating the tubular body for a certain period of time And the process of making it repeat several times. Thereby, since a plurality of layers can be formed with a predetermined gel substance, it is possible to provide an artificial blood vessel having a feel similar to a living blood vessel having an inner membrane, a middle membrane and an outer membrane and a plurality of layers. Become.

  Further, in the method for manufacturing an artificial blood vessel according to the present invention, a predetermined gel material that immerses the tubular body in which the rod-like body is inserted is colored with a different color pigment (white, red, etc.). Thereby, layers of different colors can be formed with a predetermined gel-like substance, so that it is possible to provide an artificial blood vessel having an appearance similar to a biological blood vessel having a complex color.

  In the method for producing an artificial blood vessel according to the present invention, before the rod-shaped body is pulled out from the tubular body, the step of inserting the rod-shaped body with the tubular body to which the predetermined gel-like substance is fixed into the tubular body made of a fiber again. And a step of immersing the tubular body in which the rod-like body is inserted in a predetermined gel substance for a predetermined time, and taking out the gel substance 3 permeating the tubular body 1 (for example, the second tubular body 1B) for a predetermined time. And a step of drying. In this case, a member corresponding to the elastic plate of the biological blood vessel can be constituted by the two tubular bodies, so that the structure of the biological blood vessel can be more closely approximated.

  In the method for producing an artificial blood vessel according to the present invention, it is desirable that the fibrous tubular body is formed by weaving specific chemical fibers by plain weaving or twill weaving or by knitting by warp knitting. When the tubular body is formed in this way, it becomes possible to impart extensibility to the tubular body. In particular, when a tubular body is formed by plain weaving, twill weaving, or warp knitting, it is possible to give the tubular body characteristics similar to an elastic plate that forms part of the arterial wall.

  Furthermore, in the method for manufacturing an artificial blood vessel according to the present invention, a groove may be formed on the surface of the rod-shaped body. In this case, since the elasticity of the artificial blood vessel is reinforced by the groove portion, it is possible to give the artificial blood vessel a characteristic more similar to a biological blood vessel.

  In particular, it is preferable that the groove portion formed in the rod-like body has a spiral shape. Thus, when the groove part formed in a rod-shaped body is made into a spiral shape, it becomes possible to easily pull out the rod-shaped body by pulling out the rod-shaped body while rotating along the groove part formed in the spiral shape. .

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  According to the present invention, a rod-like body is inserted into a tubular body made of a fibrous material, and this tubular body is taken out after being immersed in a gel-like substance generated by adding a solvent to a thermoplastic material for a certain period of time. After the infiltrated gel material is dried for a certain period of time, the rod-shaped body is pulled out from the tubular body, so it can be manufactured at low cost without going through complicated steps, and the elasticity included in the necessary conditions as a substitute blood vessel And an artificial blood vessel excellent in extensibility and a method for producing the same.

  Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings.

  In the present invention, a rod-like body is inserted into a tubular body made of a fibrous material, and this tubular body is immersed in a gel-like substance generated by adding a solvent to a thermoplastic material for a certain period of time, and then taken into the tubular body. After the gel substance is dried for a certain period of time, it can be manufactured at low cost without going through complicated processes by pulling out the rod-like body from the tubular body, and the elasticity and extensibility included in the necessary conditions as a substitute blood vessel An excellent artificial blood vessel is provided. In particular, since the artificial blood vessel according to the present invention can be manufactured inexpensively, an artificial blood vessel having elasticity and extensibility similar to that of a biological blood vessel can be used. Therefore, an artificial blood vessel suitable for use in education or practice for learning a surgical technique is used. It becomes possible to provide. Hereinafter, the member used at each process of the manufacturing method of the artificial blood vessel which concerns on this invention, and the processing content using the said member are demonstrated.

  FIG. 1 is a schematic diagram showing an example of a tubular body used in a method for manufacturing an artificial blood vessel according to an embodiment of the present invention. The tubular body 1 shown in FIG. 1 is formed by weaving or knitting a specific chemical fiber. As the specific chemical fiber, for example, wooly nylon, polyester, rayon or the like is used. In each chemical fiber, for example, 8, 12, 16, 24, 40 and 70 deniers are used. The tubular body 1 corresponds to, for example, an elastic plate forming a part of an arterial wall in a state where an artificial blood vessel is manufactured by being covered with a predetermined gel substance as will be described later.

  When the tubular body 1 is formed by weaving specific chemical fibers, for example, plain weave or twill weave (jersey weave) is used. On the other hand, when a specific chemical fiber is formed by knitting, for example, warp knitting is used. Thus, it becomes possible to impart extensibility to the tubular body 1 by forming the tubular body 1 by weaving or knitting specific chemical fibers. In particular, when the tubular body 1 is formed by plain weaving, twill weaving, or warp knitting, it is possible to give the tubular body 1 a characteristic that approximates an elastic plate that forms part of the artery wall. In the present embodiment, the case where the tubular body 1 is formed by twilling 40 denier woolly nylon will be described.

  In the artificial blood vessel manufacturing method according to the present embodiment, the rod-shaped body 2 is inserted into the tubular body 1 configured as described above. FIG. 2 is a schematic diagram showing a state where a rod-like body is inserted into the tubular body. The rod-shaped body 2 is composed of a conductive metal (hereinafter, the rod-shaped body 2 composed of such a metal is appropriately referred to as “metal rod 2”). The metal rod 2 is made of stainless steel, for example. When the metal rod 2 is inserted into the tubular body 1, it is preferable that the tubular body 1 is disposed at the central portion of the metal rod 2 and both ends of the metal rod 2 are exposed as shown in FIG. 2.

  In the method for manufacturing an artificial blood vessel according to the present embodiment, the tubular body 1 into which such a metal rod 2 is inserted is immersed in a predetermined gel material for a predetermined time and then taken out, and the gel material that has permeated the tubular body 1 Let dry for a certain period of time to cure. At that time, in order to prevent the tubular body 1 attached to the metal rod 2 from deviating from a certain position, first, both ends of the tubular body 1 are immersed in the gel material and then dried for a certain period of time. Secure to bar 2. FIG. 3 is a schematic diagram showing a state where a predetermined gel-like substance is attached to both ends of the tubular body. In the state shown in FIG. 3, the gel-like substance 3 attached to both ends of the tubular body 1 is cured, so that the tubular body 1 is fixed to the metal rod 2.

Here, a predetermined gel-like substance that immerses (dipping) the tubular body 1 in which the metal rod 2 is inserted will be described. The predetermined gel-like substance is produced by adding a certain amount of solvent to the thermoplastic material produced through a special process. Specifically, a certain proportion of lubricating oil is added to the first SEBS powder obtained by pulverizing powder made of thermoplastic elastomer (Clayton Polymer Japan Co., Ltd .: Clayton (registered trademark) G: G1654X) into ultrafine particles. (Idemitsu Kosan Co., Ltd .: liquid paraffin, Daphne oil CP, 12N) is added and stirred to form a gel. At this time, the ratio of the first SEBS powder to the lubricating oil is set to a ratio of 1: 7.5. The gel-like substance produced | generated by this is called gel-like substance (A).

On the other hand, a certain percentage of lubricating oil (Idemitsu Kosan Co., Ltd.) is added to the second SEBS powder obtained by grinding powder made of thermoplastic elastomer (Clayton Polymer Japan Co., Ltd .: Clayton (registered trademark) G: G1654X) into ultrafine particles. Made by Corporation: liquid paraffin, Daphne oil CP, 12N) and stirred well. The second SEBS powder differs from the first SEBS powder in the size of the particles in the secondary processing, and is set to be larger than the particles of the first SEBS powder. At this time, the ratio between the second SEBS powder and the lubricating oil is set to a ratio of 1: 6. And after adding the said gel-like substance (A) to this and stirring, it stabilizes for 72 hours and makes it gelatinous. The gel-like substance produced | generated by this is called gel-like substance (B). This gel-like substance (B) corresponds to a thermoplastic material produced through the special process.

  By adding 80% of the solvent of the total amount of the gel substance (B) and stably fusing for 48 hours or more in a cool and dark place, the predetermined gel substance is generated. Examples of the solvent added to the gel substance (B) include toluene and heptane. In this embodiment mode, the case where toluene is used as a solvent is shown.

  The tubular body 1 is fixed to the metal rod 2 by immersing both ends of the tubular body 1 into which the metal rod 2 is inserted in the predetermined gel material thus generated, and then drying for a certain period of time. Thereafter, the entire tubular body 1 fixed to the metal rod 2 is soaked for a certain period of time and then taken out and dried for a certain period of time so that the gel substance 3 that has penetrated into the tubular body 1 is cured.

  It should be noted that any method may be used when the both ends of the tubular body 1 or the entirety thereof are immersed in the predetermined gel material 3. As shown in FIG. 4, the simplest method is to put the predetermined gel-like substance 3 in a measuring cylinder and move it up and down while holding the upper end of the metal rod 2 with tweezers or the like. It is conceivable to immerse the part or the whole. Thus, the tubular body 1 in the state shown in FIG. 3 is obtained, and the tubular body 1 in the state shown in FIG. 5 is obtained. FIG. 5 is a schematic diagram showing a state where a predetermined gel-like substance 3 is attached to the entire tubular body.

  Here, the case where the upper end portion of the metal rod 2 is moved up and down while being gripped by tweezers and the like is illustrated so as to immerse both end portions or the whole of the tubular body 1, but the tubular body 1 has a predetermined gel shape. The method of immersing in the substance 3 is not limited to this, and can be changed as appropriate. In particular, it is preferable as an embodiment to automate a part or the whole of work in consideration of improvement in workability. When considering the step of immersing the tubular body 1 in a predetermined gel-like substance 3, the tubular body 1 is set longer than the metal rod 2, and the portion protruding from the end of the metal rod 2 is tweezers or It may be held by hand.

  In the method for manufacturing an artificial blood vessel according to the present embodiment, the entire tubular body 1 fixed to the metal rod 2 is taken out after being immersed for a certain period of time, and the gel-like substance 3 that has permeated the tubular body 1 is cured for a certain period of time. When performing the drying process, the process is repeated or the predetermined gel-like substance 3 is colored with a specific color pigment in order to approximate the appearance and shape of the biological blood vessel. Hereinafter, in the method for manufacturing an artificial blood vessel according to the present embodiment, specific operations performed in this process will be described. Here, a case where an artificial blood vessel having an outer shape of 2.6 mm (inner diameter of 1.6 mm) is manufactured will be described.

  In the previous stage of performing the above steps, the predetermined gel substance 3 colored white with a pigment (hereinafter referred to as “white gel 3W”) and the predetermined gel substance colored red with a pigment (hereinafter referred to as “white gel 3W”) "Red gel 3R") is prepared in advance. First, the tubular body 1 is immersed in the white gel 3W for 10 seconds and then taken out and dried for 1 hour. Then, the tubular body 1 dried for 1 hour is immersed in the red gel 3R for 10 seconds and then taken out and dried for 1 hour. Further, the tubular body 1 dried for 1 hour is again immersed in the white gel 3W for 10 seconds and then taken out and dried for 8 hours. When manufacturing an artificial blood vessel having an outer diameter of 2.6 mm, the above process is completed after performing the above-described processing.

  FIG. 6 is a cross-sectional view of an artificial blood vessel manufactured through this process. As shown in FIG. 6, in the artificial blood vessel, the tubular body 1 is mounted on the peripheral surface of the metal rod 2, the red gel 3R is attached to the upper layer, and the white gel 3W is further attached to the upper layer. In addition, about the white gel 3W first adhered to the metal rod 2, it is assumed that it has penetrated the tubular body 1, and is omitted in FIG. Thus, the surface of the artificial blood vessel is formed by covering the peripheral surface of the tubular body 1 attached along the surface of the metal rod 2 with a plurality of layers of the predetermined gel-like substance 3.

  Although an artificial blood vessel having an outer diameter of 2.6 mm is described here, it is possible to manufacture a blood vessel having an outer diameter larger or smaller than this. As an operation example when manufacturing a product having a large outer shape, for example, it is conceivable to repeat a step of immersing the tubular body 1 in the red gel 3R and a step of immersing the tubular body 1 in the white gel 3W. On the other hand, as an operation example when manufacturing a product having a small outer diameter, it is conceivable to reduce the amount of adhesion to the tubular body 1 by shortening the time of immersion in each gel material 3.

  In addition, here, a case where one metal tubular body 1 is covered with a fibrous tubular body 1 is shown, but a different tubular body 1 may be additionally covered. In the following, the fibrous tubular body 1 that first covers the metal rod 2 is referred to as a first tubular body 1A, and the tubular body 1 that is subsequently covered is referred to as a second tubular body 1B. In this case, the second tubular body 1B is preferably covered with a predetermined gel-like substance 3 attached to the first tubular body 1A and dried for a predetermined time. As described above, the tubular body 1 corresponds to an elastic plate forming a part of the arterial wall, but an outer elastic plate and an inner elastic plate exist on the arterial wall. When covering the second tubular body 1B in this way, the first tubular body 1A can constitute an inner elastic plate, and the second tubular body 1B can constitute an outer elastic plate. It is possible to approximate the structure of a blood vessel.

  FIG. 7 is a cross-sectional view of an artificial blood vessel manufactured by covering the second tubular body 1B in this way. In addition, in FIG. 7, although it has shown about the case where the gel-like substance 3 adhering to the upper layer of the 1st tubular body 1A or the 2nd tubular body 1B is one layer, it is not limited to this. As shown in FIG. 6, a plurality of layers may be formed with the gel material 3. In the artificial blood vessel shown in FIG. 7, the first tubular body 1 </ b> A is attached to the peripheral surface of the metal rod 2, and the gel substance 3 is attached to the upper layer. And the 2nd tubular body 1B is mounted | worn with the upper layer of this gel-like substance 3, and the gel-like substance 3 has adhered to the upper layer. Thus, the surface of the artificial blood vessel is formed by covering the peripheral surfaces of the first tubular body 1A and the second tubular body 1B attached along the surface of the metal rod 2 with the predetermined gel-like substance 3.

  After forming the surface of the artificial blood vessel in this way, in the method for manufacturing the artificial blood vessel according to the present embodiment, the gel-like substance 3 attached to the peripheral surface of the metal rod 2 by flowing a predetermined amount of current through the metal rod 2. Is dissolved and left for a certain period of time to dry the part. FIG. 8 is a schematic diagram showing a configuration when a current is passed through the metal rod 2. As shown in FIG. 8, the gel-like substance 3 attached to the peripheral surface of the metal rod 2 is temporarily attached by connecting a power source V to the both ends of the metal rod 2 protruding from the tubular body 1 through a conducting wire and causing a current to flow. To dissolve.

  The current flowing through the metal rod 2 can be appropriately changed as long as the metal rod 2 can be heated by heating to a temperature at which the predetermined gel-like substance 3 is dissolved. The predetermined gel-like substance 3 used in the method for manufacturing an artificial blood vessel according to the present embodiment is dissolved at about 160 ° C. For this reason, for example, as long as the temperature and current of the metal bar 2 can be heated to 180 to 200 ° C., any value may be set as long as the cost in the manufacturing process allows.

  The reason why the gel-like substance 3 adhering to the periphery of the metal rod 2 is temporarily dissolved is to make it easy to pull out the metal rod 2 in the subsequent process. Moreover, the inner surface of the artificial blood vessel corresponding to the inner wall of the biological blood vessel can be smoothed by temporarily dissolving the gel-like substance 3 attached to the periphery of the metal rod 2 in this way. By smoothing the inner surface of the artificial blood vessel in this way, the inner surface can be made to have a shape that approximates a biological blood vessel.

  After the gel-like substance 3 attached to the periphery of the metal rod 2 is temporarily dissolved, the metal rod 2 is pulled out from the tubular body 1 in the method for manufacturing an artificial blood vessel according to the present embodiment. FIG. 9 is a schematic diagram showing a state after the metal rod 2 is pulled out from the tubular body 1. As shown in FIG. 9, after the metal rod 2 is pulled out, the predetermined gel-like substance 3 penetrates into the fibrous portion of the tubular body 1 and is cured with an appropriate elasticity. On the other hand, the fiber part of the tubular body 1 is given extensibility by weaving specific chemical fibers. Thereby, the tubular body 1 which has the elasticity and extensibility which approximate a biological blood vessel is comprised.

  By cutting both end portions of the artificial blood vessel thus obtained to a desired length, an artificial blood vessel by the method for manufacturing an artificial blood vessel according to the present embodiment is completed. In the artificial blood vessel manufacturing method according to the present embodiment, since the surface of the artificial blood vessel is constituted by the predetermined gel substance 3, the surface may be sticky. Assuming such a case, it is preferable as an embodiment to add a step of attaching a predetermined powder for suppressing stickiness to the final step. In this case, since the predetermined powder suppresses excessive stickiness generated on the surface of the artificial blood vessel, it becomes possible to more closely approximate the surface characteristics of the biological blood vessel.

  Thus, according to the method for manufacturing an artificial blood vessel according to the present embodiment, a rod-like body 2 is inserted into a tubular body 1 made of a fiber, and the tubular body 1 is produced by adding a solvent to a thermoplastic material. Since the gel-like substance 3 that has been immersed in the gel-like substance 3 for a certain period of time is taken out and dried and the gel-like substance 3 that has permeated the tubular body 1 is dried for a certain period of time, the rod-like body 2 is pulled out from the tubular body 1. Therefore, it is possible to provide an artificial blood vessel that can be manufactured at low cost and has excellent elasticity and extensibility that are included in the necessary conditions as a substitute blood vessel.

  In particular, in the method for manufacturing an artificial blood vessel according to the present embodiment, the surface of the artificial blood vessel is formed by infiltrating the tubular body 1 with a gel substance 3 produced by adding a certain ratio of solvent to the thermoplastic material. I am trying to configure it. This makes it possible to generate an artificial blood vessel of uniform thickness by effectively utilizing the time until curing, unlike a substance that is dissolved by heat, and it is possible to improve workability in the manufacturing process. Become.

Further, in the method for manufacturing an artificial blood vessel according to the present embodiment, lubricating oil is added to the first SEBS powder obtained by pulverizing the above thermoplastic material into powder composed of thermoplastic elastomer into ultrafine particles. After the gel substance (A) is produced, lubricating oil is added to the second SEBS powder obtained by pulverizing the powder composed of thermoplastic elastomer into ultrafine particles, and the gel substance (A) is stirred. In addition, it is generated by stirring. Thereby, for example, in the gel substance (A), the elasticity imparted to the artificial blood vessel can be changed by changing the ratio of the lubricating oil to the first SEBS powder. In addition, the material produced from the second SEBS powder having a particle size larger than that of the first SEBS powder is agitated with the gel material (A) to produce the thermoplastic material. At the same time, it is possible to provide an artificial blood vessel having a feeling of incision similar to a biological blood vessel.

  In the method for manufacturing an artificial blood vessel according to the present embodiment, as described above, since an artificial blood vessel having elasticity and extensibility that approximates a biological blood vessel can be manufactured at low cost, education for learning a surgical technique or It is possible to provide a suitable artificial blood vessel when used for practice. In particular, when applied to an artificial blood vessel used for education or practice, as described above, by changing the elasticity of the artificial blood vessel, an artificial similar to a pathological biological blood vessel (for example, an arteriosclerotic blood vessel). Blood vessels can be manufactured. As a result, it is possible to learn a surgical technique for a pathological biological blood vessel that can usually be learned only in the clinic.

Further, in the method for manufacturing an artificial blood vessel according to the present embodiment, the thermoplastic material is added to the first SEBS powder and a lubricating oil is added to produce a gel substance (A), and then the second SEBS powder is used. It produces | generates by adding lubricating oil and stirring, adding the said gel-like substance (A) and stirring. However, the method for producing the thermoplastic material can be changed as appropriate. For example, the step of using the second SEBS powder is omitted, and the gel material formed by adding lubricating oil to SEBS powder obtained by pulverizing powder composed of thermoplastic elastomer into ultrafine particles is used as the thermoplastic material. Can also be used. Even when the thermoplastic material thus produced is used, the elasticity imparted to the artificial blood vessel can be changed by changing the ratio of the lubricating oil to the thermoplastic elastomer .

  Furthermore, in the present embodiment, a case is described in which the ratio of the first SEBS powder and the lubricating oil is set to a ratio of 1: 7.5. In an artificial blood vessel manufactured by this manufacturing method, it is known that the elasticity imparted to the artificial blood vessel changes by changing these ratios. That is, the elasticity of the artificial blood vessel can be reduced by increasing the ratio of the lubricating oil to the first SEBS powder (the artificial blood vessel can be softened). On the other hand, by reducing the ratio of the lubricating oil, the elasticity of the artificial blood vessel can be increased (the artificial blood vessel can be hardened). In particular, in the artificial blood vessel manufactured by this manufacturing method, when the ratio of the first SEBS powder and the lubricating oil is manufactured at 1: 4.0 to 7.5, it is preferably used for education or practice. Is possible.

  Further, in the method for manufacturing an artificial blood vessel according to the present embodiment, before immersing the tubular body 1 into which the rod-shaped body 2 is inserted in the predetermined gel-like substance 3, both ends of the tubular body 1 are attached to the gel-like substance 3. It fixes to the rod-shaped body 2 by. This prevents the tubular body 1 attached to the rod-like body 2 from being displaced from a certain position, so that the gel-like substance 3 can be evenly attached to the tubular body 1.

  In the method for manufacturing an artificial blood vessel according to the present embodiment, the rod-shaped body 2 is made of a conductive metal, and before the rod-shaped body 2 is pulled out from the tubular body 1, an electric current is passed through the rod-shaped body 2 to The gel substance 3 around the rod-like body 2 is dissolved. Thereby, it becomes possible to make it easy to pull out the rod-shaped body 2. Moreover, since the inner surface of the artificial blood vessel corresponding to the inner wall of the biological blood vessel can be smoothed, the inner surface can also have a shape that approximates the biological blood vessel.

  Further, in the method for manufacturing an artificial blood vessel according to the present embodiment, a step of taking out the tubular body 1 in which the rod-like body 2 is inserted after being immersed in a predetermined gel-like substance 3 for a certain period of time, and a gel permeating the tubular body 1 The step of drying the particulate material 3 for a predetermined time is repeated a plurality of times. Thereby, since a plurality of layers can be formed with the predetermined gel substance 3, an artificial blood vessel having a feeling similar to a biological blood vessel having an inner membrane, a middle membrane and an outer membrane and a plurality of layers can be provided. It becomes.

  Further, in the method for manufacturing an artificial blood vessel according to the present embodiment, the predetermined gel material 3 that immerses the tubular body 1 in which the rod-like body 2 is inserted is colored with different color pigments (white, red, etc.). As a result, layers of different colors can be formed with the predetermined gel-like substance 3, so that it is possible to provide an artificial blood vessel having an appearance similar to a biological blood vessel having a complex color. In addition, it is possible to provide an artificial blood vessel corresponding to an artery or a vein by coloring the predetermined gel-like substance 3 with a different color pigment.

  In the method for manufacturing an artificial blood vessel according to the present embodiment, the tubular body 1 (for example, the first tubular body 1A described above) to which a predetermined gel-like substance 3 is fixed before the rod-shaped body 2 is pulled out from the tubular body 1 is used. And the step of inserting the attached rod-like body 2 into the tubular body 1 made of a fiber again (for example, the second tubular body 1B), and the tubular body 1 in which the rod-like body 2 is inserted (for example, the second tubular body). 1B), after immersing in a predetermined gel-like substance 3 for a certain period of time, and taking it out; and drying the gel-like substance 3 that has permeated into the tubular body 1 (for example, the second tubular body 1B) for a certain period of time. You may make it do. In this case, since the two tubular bodies 1 can constitute a member corresponding to the elastic plate of the biological blood vessel, it is possible to more closely approximate the structure of the biological blood vessel.

  The present invention is not limited to the above-described embodiment, and can be implemented with various modifications. In the above-described embodiment, the size, shape, and the like illustrated in the accompanying drawings are not limited to this, and can be appropriately changed within a range in which the effect of the present invention is exhibited. In addition, various modifications can be made without departing from the scope of the object of the present invention.

  For example, in the method for manufacturing an artificial blood vessel according to the above-described embodiment, a case where an artificial blood vessel is manufactured using a rod-shaped body 2 having a normal peripheral surface is shown. However, the present invention is not limited to this, and the shape of the rod-like body 2 can be appropriately modified. For example, a groove portion may be formed on the peripheral surface of the rod-shaped body 2. In this case, it is preferable as an embodiment to make the groove formed in the rod-like body 2 spiral. When the groove is formed in a spiral shape, the rod-shaped body 2 can be easily pulled out by pulling out the rod-shaped body 2 while rotating along the groove formed in a spiral shape. Hereinafter, a modification in which a spiral groove is formed on the peripheral surface of the rod-like body 2 will be described.

  FIG. 10 is a schematic diagram of the rod-like body 2 having a spiral groove (hereinafter referred to as “spiral groove”) formed on the peripheral surface. As shown in FIG. 10, a spiral groove 2 </ b> A that is led from one end to the other end is formed on the peripheral surface of the rod-like body 2. When the method for manufacturing an artificial blood vessel according to the above embodiment is executed using the rod-like body 2 in which the spiral groove 2A is formed in this way, a predetermined gel-like substance 3 is adhered to the entire rod-like body 2. In this case, the shape of the gel-like substance 3 around the rod-like body 2 is different from the above embodiment.

  That is, when the method for manufacturing an artificial blood vessel according to the above embodiment is executed using the rod-like body 2 in which the spiral groove 2A is formed, the predetermined gel-like substance 3 enters the inside of the spiral groove 2A. And when it dries for a fixed time, it hardens | cures with the shape which entered 2 A of spiral grooves. FIG. 11 is a cross-sectional view of an artificial blood vessel manufactured using the rod-shaped body 2 shown in FIG. Unlike FIG. 6, FIG. 11 shows a cross-sectional view after the rod-shaped body 2 is pulled out for convenience of explanation. As shown in FIG. 11, when manufactured using the rod-shaped body 2 shown in FIG. 10, unlike the cross section of the artificial blood vessel shown in FIG. 6, a predetermined shape formed along the spiral groove 2 </ b> A inside the tubular body 1. The gel-like substance 3 is arranged.

  In the artificial blood vessel manufactured in this way, the elasticity in the artificial blood vessel is reinforced by the predetermined gel substance 3 arranged inside the tubular body 1, and thus the characteristics more approximate to the biological blood vessel are given. It becomes possible to do.

  The present invention inserts a rod-shaped body made of a fibrous material, soaks the tubular body in a gel-like substance formed by adding a solvent to a thermoplastic material for a certain period of time, and then removes the gel-like substance that has permeated the tubular body. After being dried for a certain period of time, the metal rod is pulled out from the tubular body and can be manufactured at low cost without going through a complicated process, and it has excellent elasticity and extensibility included in the necessary conditions as a substitute blood vessel. An artificial blood vessel is provided and has industrial applicability.

It is a schematic diagram which shows an example of the tubular body used with the manufacturing method of the artificial blood vessel which concerns on one embodiment of this invention. It is a schematic diagram shown about the state at the time of a rod-shaped body being inserted in the tubular body. It is a schematic diagram shown about the state at the time of making a predetermined gel-like substance adhere to the both ends of a tubular body. It is a figure for demonstrating an example of the method at the time of immersing the both ends or the whole of a tubular body in a predetermined gel-like substance. It is a schematic diagram shown about the state at the time of making a predetermined gel-like substance adhere to the whole tubular body. It is sectional drawing of the artificial blood vessel manufactured through the specific process of the manufacturing method of the artificial blood vessel which concerns on this Embodiment. It is sectional drawing of the artificial blood vessel manufactured by covering a some tubular body. It is a schematic diagram shown about the structure at the time of flowing an electric current through a metal bar. It is a schematic diagram shown about the state after pulling out a metal stick from a tubular body. It is a schematic diagram of the rod-shaped body in which the spiral groove part was formed in the surrounding surface. It is sectional drawing of the artificial blood vessel manufactured using the rod-shaped body shown in FIG.

1: Tubular body 2: Bar-shaped body (metal bar)
3: Gel-like substance

Claims (10)

(A) inserting a conductive rod-like body into a tubular body made of a fiber;
(B) a step of immersing a gel-like substance generated by adding lubricating oil to a thermoplastic elastomer powder and stirring in a tubular body in which the rod-like body is inserted;
(C) withdrawing the tubular body in which the rod-like body is inserted;
(D) dissolving the gel-like substance around the rod-like body by passing an electric current through the rod-like body, and drying the gel-like substance permeating the tubular body;
(E) extracting the rod-shaped body from the tubular body;
A method for producing an artificial blood vessel, comprising: The thermoplastic material includes a first intermediate formed by adding the lubricating oil to a first powder obtained by pulverizing a powder made of the thermoplastic elastomer into fine particles, and the thermoplastic A second intermediate produced by adding the lubricating oil to a second powder having a particle size larger than that of the first powder obtained by pulverizing a powder made of elastomer into fine particles; The method for producing an artificial blood vessel according to claim 1, wherein the artificial blood vessel is produced by stirring. The end of the tubular body is fixed to the rod-like body with the gel-like substance before the tubular body into which the rod-like body is inserted is immersed in the gel-like substance. A method for manufacturing an artificial blood vessel. The method for producing an artificial blood vessel according to claim 1, wherein the gel-like substance that immerses the tubular body in which the rod-like body is inserted is colored with a different color pigment. The method for producing an artificial blood vessel according to claim 1, wherein the fibrous body is formed by weaving specific chemical fibers. The method for producing an artificial blood vessel according to claim 5, wherein the fibrous tubular body is formed by plain weaving a specific chemical fiber. The method for manufacturing an artificial blood vessel according to claim 5, wherein the tubular body made of a fibrous material is formed by twilling a specific chemical fiber. The method for manufacturing an artificial blood vessel according to claim 7, wherein the tubular body made of the fibrous material is formed by warp knitting a specific chemical fiber. The method for producing an artificial blood vessel according to claim 1, wherein a groove is formed on the surface of the rod-shaped body. The method for manufacturing an artificial blood vessel according to claim 9, wherein the groove is formed in a spiral shape.

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