CN105448170B - A kind of imitative body Model including tree-shaped pipeline configuration - Google Patents
A kind of imitative body Model including tree-shaped pipeline configuration Download PDFInfo
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- CN105448170B CN105448170B CN201410409173.9A CN201410409173A CN105448170B CN 105448170 B CN105448170 B CN 105448170B CN 201410409173 A CN201410409173 A CN 201410409173A CN 105448170 B CN105448170 B CN 105448170B
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Abstract
The invention belongs to medicine and hygiene fields, it is related to a kind of imitative body Model, more particularly to a kind of imitative body Model for including tree-shaped pipeline configuration, imitative body Model of the invention, including perienchyma's the jellium model and hollow pipe model, the hollow pipe model is that there is no separation membrane or partition walls between the pipeline being formed directly into inside perienchyma's the jellium model, with perienchyma's glue.The model has the advantages that sound transparency is good, the quality of ultrasonogram has been effectively ensured, the critical piping structure of (such as liver) can be simulated effectively in human body, obtain better simulation quality, keep the use scope of model wider, it can be used as sign structure when ablation techniques plan, it may also be used for the training and training of cavity shadowgraph technique.
Description
Technical field
The invention belongs to medicine and hygiene fields, are related to a kind of imitative body Model, specifically, being related to one kind to simulate human body
The imitative body Model of blood vessel tree.
Background technique
Imitative tissue model is crucial in the study and training of amnio-infusion and common tool.However, currently used for
It imitates the imitative body Model of human vas tree construction and its realizes that technology is still very limited.Imitating human vas perienchyma side
Face, since spread speed of the ultrasound in OK a karaoke club micelle colloid is closer to human body truth, frequently with carragheen conduct
Cast material.And in terms of imitating human vas, since the ultrasonogram in human vas shows as echoless, can use
Anechoic solid material is embedded within perienchyma's glue, however, vascular pattern at this time be actually it is solid, with human body
Actual conditions are not inconsistent, it is also difficult to be filled predetermined substance in vascular pattern if necessary and be studied.Another way is
Hollow pipe is embedded within perienchyma's glue, has one between the hollow pipe inside simulated blood vessel and perienchyma's glue at this time
Layer duct wall, although such model closer to actual conditions (there is also vascular walls for human body), however, it is found by the inventors that at present
The duct wall that used material is simulated will affect ultrasonic penetration, influence the Quality of acoustical image graphic in pipeline.
Summary of the invention
It is an object of the present invention to provide the imitative body Models of a kind of novel simulation human vas or bile duct.
The second purpose of the present invention is to provide a kind of imitative body Models of novel simulation human vas tree.
The three of the object of the invention are to provide the preparation method of above-mentioned imitative body Model.
Above-mentioned purpose is realized by the following technologies in invention:
Invention provides a kind of imitative body Model, including perienchyma's the jellium model and hollow pipe model, and described is hollow
Pipeline model be between the pipeline being formed directly into inside perienchyma's the jellium model, with perienchyma's glue there is no separation membrane or
Partition wall.
Perienchyma's glue (host material) contains one of agarose, agar, konjac glucomannan, carragheen, gelatin or a variety of.
Inventors have found that this kind of model is although there is no the duct wall/film for imitating vascular wall, which instructs in ultrasound
The clear display pipes inner case of energy, will not generate ultrasonic attenuation phenomenon caused by pipeline wall material in white silk.
Preferably, the hollow pipe in the imitative body Model is the hollow pipe of two-stage or multilevel branch.Body is imitated at this time
Model includes tree-shaped cavity channel, can be used for simulating human body (liver) blood vessel or bile duct, and not yet discovery includes tree on the market at present
The imitative body Model of shape cavity channel, the simulation of human vas mostly use solid tube-like materials, and fidelity is not high, and application range is narrow.
This imitative body Model includes tree-shaped cavity channel structure, and ultrasonic findings are tree-shaped echoless structure, has the advantages that sound transparency is good,
The quality of ultrasonogram has been effectively ensured, can effectively simulate in human body the critical piping structure of (liver), can be used as ablation techniques meter
Sign structure when drawing, it may also be used for the training and training of cavity shadowgraph technique.Also registration marks when image registration be can be used as,
Especially suitable for occurring the new technology based on the image registration of three-D ultrasonic-ultrasound recently, (technology is by extracting in model
Echoless pipeline configuration carry out image registration, other imitative body Models are difficult to replace).
Preferably, perienchyma's glue of the invention uses agarose or agar for primary raw material.Although current ultrasound is imitative
The host material of body Model generallys use carragheen as primary raw material, however, in the present invention, inventor has found optimal material
Material is agarose or agar.
Although konjac glucomannan, carragheen, gelatin can be used as host material as optional material.However, in the present invention
In, inventor has attempted a variety of host materials, other than in addition to agarose and agar, performance is applicable in all respects, konjac glucomannan, card
Draw glue, the effect of gelatin then barely satisfactory.This is because:
The model of the pipelines such as simulated blood vessel/bile duct of the present invention is hollow and does not have between matrigel (perienchyma's glue)
Barrier material, it is therefore desirable to which the production for changing model preferably at least meets two conditions: 1. matrigels have suitable hardness/side
Edge integrality can be easily made hollow pipe model；2. model is placed in water body, matrigel stability with higher is kept
The integrality at edge, is not easy rust.After it compared multiple material, inventor's discovery is using agarose or agar as raw material
When making perienchyma's glue, effect is much superior to other materials.Its smooth operation that can be conducive to manufacturing process is to form
The smooth hollow pipe in surface, while the molding model of institute is still able to maintain stability after being placed in water the long period, hollow pipe
Road is indeformable, and edge is not easy rust.And konjac glucomannan, carragheen, gelatin effect are taken second place, or obtain surface light in the presence of that cannot stablize
Sliding hollow pipe problem (pipe mould has adhered to fraction matrix glue when detaching)；Or model stability when being soaked in water
It is not high, colloid dilatancy after soaking water；Or be placed in moisture content in air and be precipitated comparatively fast, deform colloid.
This difference more can be intuitively found out by the pipeline cross sectional photograph reflecting effect of Fig. 5, and Fig. 5 A is matrix material
Material selects pipeline photo when agar, and the surface known to reflecting effect is smooth, and the effect of agarose is similar with its, and Fig. 5 B is then
Using the effect of other host materials, the pipe surface bumps known to reflecting effect are rough.
And the effect of water-resistant stability can be embodied by the pipeline cross sectional photograph after impregnating.Fig. 6 is shown after immersion
Pipeline cross sectional photograph, A is Agar substrate, impregnate 24 hours after, the still good uniformity of the diameter that each section of pipeline, pipe
Road surface is smooth；B is OK a karaoke club gel matrix, and after impregnating 6 hours, the diameter that each section of pipeline is uneven, and surface owes smooth；Scheming C is
Agarose matrix impregnated 24 as a child, and surface still keeps smooth, and the pipe diameter uniformity is kept substantially.
It is highly preferred that perienchyma's glue is made of agarose-saline solution or agar-saline solution, it is described
Mass ratio 2:66~110 of agarose/agar and saline solution.Saline solution can be preferably that 0.1-3.0%w/w salt is water-soluble
Liquid；More preferably 0.9% physiological saline.
At this point, preferably stomach can be added in perienchyma's glue in order to adjust the echo intensity of the ultrasound of perienchyma's glue
Window acoustic contrast agent；The mass ratio of the agarose stomach function regulating window acoustic contrast agent is 4:1~3.
As a kind of optional scheme, imitating body Model can also further comprise tumour the jellium model and/or water pocket model.It is imitative
Body Model includes tumour the jellium model, and tumour colloid (can be selected from agar, agarose, carragheen, konjaku containing colloid raw material
One of glue, gelatin are a variety of) stomach function regulating window acoustic contrast agent, mass ratio is 2:3~5, high echo is shown as in ultrasound, easily
In resolution.It can be used as a kind of intervention puncture target in Ultrasound intervention technique drill；In the training of tumour thermal ablation techniques, can make
For ablation or planned target；In image registration techniques training, a kind of sign structure can be used as.The water pocket mould that imitative body Model includes
Type, ultrasonic findings are echoless, can be used for simulating the important features such as human gall bladder or gastrointestinal tract.In tumour heating ablation plan system
Injuring tumor periphery important feature should be avoided in timing, and the water pocket in imitative body Model is the work for playing simulation tumour periphery important feature
With.When carrying out image registration techniques training, it is alternatively arranged as sign structure when image registration.
It invents while providing the preparation method of imitative body Model, it is characterised in that the following steps are included:
(1) hardness 50~80 is selected, the rodlike or tubular material of resilience 48~55 is as pipe mould；
(2) by one of agarose, agar, konjaku flour, carragheen, gelatin or a variety of and 0.1~3.0%w/w salt water
Solution 2:66 in mass ratio~110 heats mixed dissolution, becomes perienchyma's sol solution；
(3) perienchyma's sol solution embedding pipe mould and cooled and solidified, become the perienchyma for being embedded with pipe mould
Glue；
(4) pipe mould is pulled out from perienchyma's glue and, become the imitative body Model for including hollow pipe.
In above-mentioned steps (2), preferred matrix glue material is selected as agarose or agar.
Inventors have found that the concentration of perienchyma's sol solution (such as agarose solution, agar solution) to preparation process and
Molding model also have more important influence, perienchyma's sol solution will affect the hardness and colloid solidification speed of model,
To influence molding effect and echo uniformity.By taking agarose as an example, when the ratio of agarose and salt water is less than 2:110, solidification
The hardness of colloid is excessively soft afterwards, and (pipe mould detach during) model is easy to grind or be formed not only during subsequent work
Sliding pipeline cambered surface；When the ratio of agarose and salt water is greater than 2:66, the hardness of colloid is harder after solidification, while setting rate
Comparatively fast, colloid is not only wasted, and the Echo heterogenicity for being likely to result in model casting process model is even.Inventor has found agar
When sugared and brine quality ratio 2:66~110, colloid hardness is moderate, and setting rate is moderate, is conducive to keep the uniform of model echo
Property, pipeline model, which is easy to successfully pull out, to be come, and keeps being formed by hollow pipe with smooth cambered surface.
Preferably, cooling described in step (4) is that the temperature of perienchyma's sol solution is begun to cool by 60-70 DEG C.Institute
To preferably control cooling initial temperature, it is the control because of model perfusion formative stage temperature, is fixed on by each structure
After casting die, when perienchyma's sol solution is perfused, temperature it is unsuitable it is excessively high (it is excessively high to lead to imitative body Model molding slowly, further lead
The echo uniformity of imitative body Model is caused to be difficult to ensure, and tumor model melts risk height), it is also unsuitable too low, it is too low to lead to matrix
In perfusion at agglomeration shape, imitative body Model uniformity cannot ensure glue, preferably maintain temperature at 60-70 DEG C or so.
When model is cast, is sealed after air in exclusion mold as far as possible, prevent from containing gas, shadow in imitative body Model after molding
Ring the Quality of acoustical image graphic of model.During model is cooled and shaped, turnover casting mold is paid attention to, the echo uniform one to guarantee model
It causes.
Preferably, pipe mould has the branched structure of two-stage or multistage detachable/assembling.
As a preferred solution, in terms of the production of tree, the present invention is using dismountable tree-shaped Mold Making
Cavity channel can effectively protect the integrality of imitative body Model, prevents imitative body Model from damaging in the production process and (is different from non-disconnectable
Unload the cavity channel of the tree-shaped Mold Making of formula), in terms of the connection method of detachable tree-shaped mold, using not destroying outside trunk
The connection principle of shape is attached, and the damage of model is also prevented in disassembly.Tree-shaped mold should be by tree-shaped mold when fixed
Free-end is gently fixed on pouring container wall, keeps free end in contact chamber wall.The free-end of trunk position is fixed on container
Lower center position belongs to branch free-end contacting side wall or top wall, and after imitating body Model cooling and shaping, tree-shaped mold is easy to
Find free-end.When pulling out of tree-shaped mold, it is contemplated that the connection type of tree-shaped mold, it should be by first pulling out final stage branch, lead again
Dry sequence is successively pulled out, in order to avoid damage imitative body Model.
Preferably, stomach window acoustic contrast agent, agarose stomach function regulating window acoustic contrast agent are added in solution described in step (2)
Mass ratio be 4:1~3；Preferably, salt water described in step (2) is physiological saline.
Optional step further includes the preparation of tumour colloid and/or the preparation of water pocket；In step (3), perienchyma's glue
Solution has also embedded tumour colloid and water pocket simultaneously, then coagulation forming again.
The tumour glue the preparation method comprises the following steps: by agarose, stomach window acoustic contrast agent and salt water according to mass ratio 2:3~5:
66~110 ratio heats mixing, then cooled and solidified is at tumour the jellium model.The fixation of tumour the jellium model, can be used silk thread
The fixed tumor model of right-angled intersection is in pouring container, to guarantee that tumour does not shift after casting.
Preferably, water pocket is the Membrane cover/plastic sheath/rubber sleeve for filling water.Water pocket should exclude empty in water pocket as far as possible when making
Gas, to guarantee the Quality of acoustical image graphic of ultrasound.
Compared with prior art, the invention has the following advantages:
1. the present invention produces a kind of imitative tissue model for including tree-shaped pipeline configuration, for based on vascular tree 3D ultrasound/
The verifying and training of ultrasound image registration technology, melt the experimental study of plan, and the training of cavity shadowgraph technique and ultrasonic gimmick are situated between
Enter study and the training etc. of ultrasonic technique.For the imitative liver ultrasonic body mould device and evaluation method of in-vitro evaluation of contrast medium, use
In the imitative liver ultrasonic body mould of in-vitro evaluation of contrast medium, there is acoustic characteristic similar with human liver, made for in-vitro evaluation
When shadow agent, simulation can be provided in the background ultrasound image of body.
2. imitative body Model includes tree-shaped cavity channel structure, ultrasonic findings are tree-shaped echoless structure, are similar to human body
Liver vessel not yet finds the imitative body Model for including tree-shaped cavity channel on the market at present, and tree-shaped cavity channel structure is used as should
One of primary structure of model has the advantages that sound transparency is good, the quality of ultrasonogram has been effectively ensured, can effectively simulate in human body
The critical piping structure of (such as liver), obtains better simulation quality, keeps the use scope of model wider, can be used as ablation techniques
Sign structure when plan, it may also be used for the training and training of cavity shadowgraph technique.Match fiducial mark when also can be used as image registration
Will, especially suitable for occurring the new technology based on the image registration of three-D ultrasonic-ultrasound recently, (technology is by extracting model
Interior echoless pipeline configuration carries out image registration).
3. the simulation quality of model is high, other than it includes the common structure of human body, ultrasonic characteristic is very close to human body group
It knits, 25 DEG C, the ultrasonic propagation velocity of standard atmospheric pressure drag is 1514 ± 5m/s, and the echo intensity of ultrasonogram performance is very
Close to human liver.
4. modelling is at low cost, production environment requirement is low, and stability is good, in a preferred embodiment, by agar
Body Model is imitated made from sugar is placed in 2-25 DEG C of water-bath 96 hours and after 6 months, the echo characteristics of shape and internal each structure
Nothing is substantially change.
Detailed description of the invention
Fig. 1 is tree-shaped mold schematic diagram employed in an of the invention specific embodiment, the connection type of tree-shaped mold,
The appearance profile for not influencing trunk or upper level branch is required in principle, and requires to be readily disassembled.
Fig. 2 shows the state before the pouring container casting in a specific embodiment of the invention, and pouring container is built-in with tree
What water pocket of shape mold, tumor model.Tumor model is the opaque colloid of yellow (grey arrow is signified)；Water pocket is poured water for rubber sleeve
(black arrow is signified) is made in sealing；Tree-shaped mold is that (white arrow is signified) is made in the connection of yellow silicone tube, and trunk is fixed
In the bottom wall middle position of pouring container, a second level category branch free-end is largely fixed on side wall, and small part is fixed on roof.
Fig. 3 is the two-dimensional ultrasound figure of each structure of imitative body Model:Tree-shaped pipeline configuration shows as nothing on the ultrasound image
Echo, display continuity is good, is similar to human liver's vascular system；Water pocket shows as oval nothing on the ultrasound image
Echo (black arrow is signified)；Tumor model shows as high echo on the ultrasound image (grey arrow is signified)；Perienchyma
Glue ultrasonic surface is equal echo, and echo intensity is similar to human liver.
Fig. 4 is imitative body Model three-dimensional reconstruction figure: system automatically extracts echoless region simultaneously using three-dimensional ultrasonography volume data
Give three-dimensional reconstruction, figure Oxford gray part is that tree-shaped pipeline configuration rebuilds figure and water pocket Model Reconstruction figure, bright gray parts are
Tumor model rebuilds figure.
Fig. 5 is the model cross sectional photograph of different substrates material；Colloid is by host material and 0.9% physiological saline according to 2:75
Proportion be made.
Fig. 6 is the pipeline cross sectional photograph of the model of different substrates material after steeping；Colloid is raw by host material and 0.9%
Reason salt water is made according to the proportion of 2:75, and after molder under 25 DEG C of environment, bubble takes out after a certain period of time in tap water.
Specific embodiment
The invention will be further described for following implementation, but embodiments of the present invention are not limited to implementation below
Example is introduced, all according to variation equivalent made by the principle of the present invention or theory or the flexible model for being regarded as the present invention and protecting
Farmland.
By following steps as an example, the imitative body Model of the invention containing tree can be prepared.Base in example
Matter glue is equal with the concept of perienchyma's glue.
(1) tree mold is prepared.Tree, silica gel are connected into using the different silicone tube of thickness (or silica gel stick)
Pipe diameter range 3-15cm, connect principle: tree trunk selects the maximum silicone tube of diameter, and level-one category branch selects small No.1
Silicone tube, second level category branch select smaller No.1 silicone tube, and diameter successively successively decreases.Connection type requires to be detachable, and does not influence
Trunk or the appearance profile (Fig. 1) of upper level branch, are commonly connected to 1-3 grades of branches.
(2) tumor model is prepared.By agarose powder, stomach window powder and 0.9% room temperature physiological saline according to mass ratio
The ratio of 2:3~5:66~110 is mixed, and after being heated to 70-90 degree after mixing evenly, is cooled in perfusion to mold die
Type is made.
(3) water pocket is prepared, fills to seal after water using rubber sleeve (attention drains the air in container) is made.
(4) perienchyma's glue is prepared.By agarose powder, stomach window powder and 0.9% room temperature physiological saline according to quality
Ratio than 4:1~3:132~220 is mixed, and is heated to 70-90 degree after mixing evenly, then maintain temperature at 60 degree or so
For use.
(5) model is cast.The tree-shaped mold made is fixed in pouring container, it is desirable that the free-end of tree-shaped mold is light
It is light to fix on the wall, keep free end in contact chamber wall.The free-end of trunk position is fixed on container bottom central location,
Belong to branch free-end contacting side wall or top wall, after being secured in place using silk thread compared with tumor model and water pocket, will stir
Homogeneous liquid matrigel is poured into container, and rear enclosed pouring container has been perfused (attention drains the air in container).
(6) model forming.The container cast is placed on cooling forming in ice water or cold bath, is infused in cooling procedure
Meaning interruption inverting container, keeps preferable echo uniformity after making molder.By solid state substrate glue and interior after completely cooling
Inclusion is poured out out of pouring container, finds each free-end of tree-shaped mold, is successively pulled out by the sequence of first final stage branch trunk again
Tree-shaped mold out, silicone tube successively can voluntarily fall off on tree-shaped mold in withdrawal process.Find the silk of fixed tumor model
Line is extracted one by one.
Contain tree-shaped hollow pipe inside the molding model of institute, pipe surface is smooth.
Embodiment 1
(1) tree mold is prepared.Tree, silica gel pipe diameter difference are connected into using the different silicone tube of thickness
It for 4,6,10,15mm, connects principle: two diameter 10mm silicone tubes is connected on diameter 15mm, then by 4 diameter 6mm silicon
Sebific duct is respectively connected on the silicone tube of 2 diameter 10mm, is formed the tree-shaped mold with second level category branch, is made according to the method
Make two sets of tree-shaped molds (Fig. 2).
(2) tumor model is prepared.By agarose powder, stomach window powder and 0.9% room temperature physiological saline according to mass ratio
The ratio of 2:3:100 is mixed, and after being heated to 70-90 degree after mixing evenly, is cooled and shaped and is made in perfusion to mold die.
(3) water pocket is prepared, fills to seal after water using rubber sleeve (attention drains the air in container) is made.
(4) matrigel is prepared.By agarose powder, stomach window powder and 0.9% room temperature physiological saline according to mass ratio 4:
The ratio of 1:200 is mixed, and is heated to 70-90 degree after mixing evenly, then maintains temperature stand-by at 60 degree or so.
(5) model is cast.Make two sets of tree-shaped molds are fixed in pouring container, by the free-end of tree-shaped mold
It gently fixes on the wall, keeps free end in contact chamber wall.The free-end of trunk position is fixed on container bottom center position
It sets, belongs to branch free-end contacting side wall or top wall (Fig. 2), then the perienchyma's glue stirred evenly is poured into container,
Rear enclosed pouring container has been perfused (attention drains the air in container).
(6) model forming.The container cast is placed on cooling forming in ice water or cold bath, is infused in cooling procedure
Meaning interruption inverting container, keeps preferable echo uniformity after making molder.After completely cooling by solid state substrate glue and its
Interior tree-shaped mold is poured out, and each free-end of tree-shaped mold is found, and holds free-end by the silica gel that first extraction diameter is 4mm
Pipe, then the silicone tube of diameter 6mm is extracted, then extract the silicone tube of diameter 10mm, finally extract diameter 15mm silicone tube.It is extracting
Silicone tube successively can voluntarily fall off on tree-shaped mold in the process.The process for extracting silicone tube is smooth, does not occur being adhered phenomenon,
Do not have any perienchyma's glue ingredient on the silicone tube extracted.
(7) body Model is imitated to use and detect.The use of imitative body Model: imitative body Model is placed in the sink, imitative body is drained
Air in model in tree-shaped cavity structure, fixed progress ultrasonic scan or training operation after imitating body.
The detection of imitative body Model: contain tree-shaped hollow pipe inside imitative body Model, pipe surface is smooth, sharpness of border.25
DEG C, the ultrasonic propagation velocity of standard atmospheric pressure drag is 1514m/s, very with the ultrasonic the mean propagation velocity of human body soft tissue
It is close.Property is stablized, and imitative body Model remains intact (time point 24H and 6 months) in water bath, and each section of diameter of pipeline is equal
Even, clear-cut margin, surface is smooth, and the echo characteristics of pipe shape and internal each structure is without substantially changeing, tree-shaped cavity channel knot
Structure ultrasonic findings are tree-shaped echoless, and continuity is good (Fig. 3,4).
Embodiment 2
With embodiment 1, but when preparing matrigel, agar powder, stomach window powder and 0.9% room temperature physiological saline are pressed
It is mixed according to the ratio of mass ratio 4:1:140.
The detection of imitative body Model: contain tree-shaped hollow pipe inside imitative body Model, pipe surface is smooth, sharpness of border.25
DEG C, the ultrasonic propagation velocity of standard atmospheric pressure drag is 1514m/s, very with the ultrasonic the mean propagation velocity of human body soft tissue
It is close.Property is stablized, and imitative body Model remains intact (time point 24H and 6 months) in water bath, and each section of diameter of pipeline is equal
Even, clear-cut margin, surface is smooth, and the echo characteristics of pipe shape and internal each structure is without substantially changeing, tree-shaped cavity channel knot
Structure ultrasonic findings are tree-shaped echoless, and continuity is good (Fig. 3,4).
Embodiment 3
With embodiment 1, but when preparing matrigel, the mass ratio of agarose and salt water is adjusted, carries out Comparative result.
Embodiment 4
With embodiment 1, but when preparing matrigel, the adding proportion of stomach window acoustic contrast agent is adjusted.
Embodiment 5
With embodiment 1, but in tumour glue glue, adjust the adding proportion of stomach window acoustic contrast agent.
Embodiment 6
With embodiment 1, but when preparing matrigel, agarose is replaced using carragheen.
The detection of imitative body Model: containing tree-shaped hollow pipe inside imitative body Model, sense of touch and visually observes display pipes table
Face smoothness is inferior to embodiment 1.25 DEG C, the ultrasonic propagation velocity of standard atmospheric pressure drag is 1514m/s, with human body soft tissue
Ultrasonic the mean propagation velocity it is very close.In imitative body Model water bath colloid surface easily soften (time point for 24 hours with 72h),
Each section of pipeline uneven, and edge rust, surface owes smooth.
Claims (13)
1. a kind of imitative body Model, it is characterised in that the imitative body Model includes perienchyma's the jellium model and hollow pipe mould
Type, the hollow pipe model are the pipeline being formed directly into inside perienchyma's the jellium model, with perienchyma's colloid mould
Separation membrane or partition wall are not present between type；
Perienchyma's the jellium model includes perienchyma's glue；
Perienchyma's glue is one or both of agarose, agar；
Perienchyma's glue is made of agarose/agar-saline solution, the agarose/agar and saline solution
Mass ratio 2:66~110；
Perienchyma's glue also contains stomach window acoustic contrast agent；The mass ratio of the agarose stomach function regulating window acoustic contrast agent
For 4:1~3.
2. imitative body Model as described in claim 1, it is characterised in that the hollow pipe in the imitative body Model is multistage point
The hollow pipe of branch.
3. imitative body Model as described in claim 1, it is characterised in that the imitative body Model further include tumour the jellium model and/
Or water pocket model.
4. imitative body Model as claimed in claim 3, which is characterized in that the tumour the jellium model contains agarose stomach function regulating window
Acoustic contrast agent, mass ratio are 2:3~5.
5. a kind of preparation method of imitative body Model as described in claim 1, it is characterised in that the following steps are included:
(1) select rodlike or tubular material as pipe mould；
(2) one or both of agarose, agar and 0.1-3.0%w/w saline solution 2:66 in mass ratio~110 are heated
Mixed dissolution becomes perienchyma's sol solution；In perienchyma's sol solution be added with stomach window acoustic contrast agent, agarose and
The mass ratio of stomach window acoustic contrast agent is 4:1~3；
(3) perienchyma's sol solution embedding pipe mould and cooled and solidified, become the perienchyma's glue for being embedded with pipe mould；
(4) pipe mould is pulled out from perienchyma's glue and, become the imitative body Model for including hollow pipe, i.e. hollow pipe
Road model.
6. preparation method as claimed in claim 5, it is characterised in that the pipe mould has multistage detachable/assembling
Branched structure.
7. preparation method as claimed in claim 5, it is characterised in that rodlike or tubular material the hardness 50~80 is returned
Elasticity 48~55.
8. preparation method as claimed in claim 5, which is characterized in that the rodlike or tubular material is silica gel material.
9. preparation method as claimed in claim 5, it is characterised in that it is 0.9% that saline solution described in step (2), which is concentration,
Physiological saline.
10. preparation method as claimed in claim 5, it is characterised in that the temperature of perienchyma's sol solution is by 60-70 DEG C
It begins to cool.
11. preparation method as claimed in claim 5, it is characterised in that the step further includes the preparation of tumour colloid, and/
Or the preparation of water pocket；In step (3), perienchyma's sol solution has also embedded tumour colloid and water pocket simultaneously, then solidifies again
Molding；The tumour colloid the preparation method comprises the following steps: by agarose, stomach window acoustic contrast agent and salt water according to mass ratio 2:3~5:
66~110 ratio heats mixing, then cooled and solidified is at tumour the jellium model.
12. preparation method as claimed in claim 11, it is characterised in that the water pocket is the Membrane cover for filling water.
13. preparation method as claimed in claim 12, it is characterised in that the Membrane cover is plastic sheath/rubber sleeve.
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| CN109859595A (en) * | 2019-01-28 | 2019-06-07 | 深圳大学 | A kind of blood vessel network ultrasound imitates body and production method |
| CN110927252B (en) * | 2019-10-30 | 2023-05-12 | 深圳大学 | Targeted shear wave elastography detection method |
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