CN110421853A - A kind of cranium brain model of emulation and preparation method thereof - Google Patents
A kind of cranium brain model of emulation and preparation method thereof Download PDFInfo
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- CN110421853A CN110421853A CN201910518087.4A CN201910518087A CN110421853A CN 110421853 A CN110421853 A CN 110421853A CN 201910518087 A CN201910518087 A CN 201910518087A CN 110421853 A CN110421853 A CN 110421853A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
- B22F10/10—Formation of a green body
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B22—CASTING; POWDER METALLURGY
- B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
- B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B28—WORKING CEMENT, CLAY, OR STONE
- B28B—SHAPING CLAY OR OTHER CERAMIC COMPOSITIONS; SHAPING SLAG; SHAPING MIXTURES CONTAINING CEMENTITIOUS MATERIAL, e.g. PLASTER
- B28B1/00—Producing shaped prefabricated articles from the material
- B28B1/001—Rapid manufacturing of 3D objects by additive depositing, agglomerating or laminating of material
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
- B29C64/10—Processes of additive manufacturing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
- B29C64/30—Auxiliary operations or equipment
- B29C64/386—Data acquisition or data processing for additive manufacturing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y10/00—Processes of additive manufacturing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y50/00—Data acquisition or data processing for additive manufacturing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
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- G—PHYSICS
- G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
- G09B—EDUCATIONAL OR DEMONSTRATION APPLIANCES; APPLIANCES FOR TEACHING, OR COMMUNICATING WITH, THE BLIND, DEAF OR MUTE; MODELS; PLANETARIA; GLOBES; MAPS; DIAGRAMS
- G09B23/00—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes
- G09B23/28—Models for scientific, medical, or mathematical purposes, e.g. full-sized devices for demonstration purposes for medicine
- G09B23/30—Anatomical models
- G09B23/34—Anatomical models with removable parts
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P10/00—Technologies related to metal processing
- Y02P10/25—Process efficiency
Abstract
The invention discloses cranium brain models of a kind of emulation and preparation method thereof.Emulation cranium brain model includes containing the cranium brain model and the simulation tumour device inside cranium brain model that can pull brain tissue, simulation tumour device be in contact with brain tissue can be pulled, simulation tumour device include soft material prepare the main body with cavity and set on the opening of body surfaces and the plugging device of occlusion of openings.Emulation cranium brain model of the invention utmostly simulates the elasticity and sense of touch of true brain tissue, and simulation tumour device is located in cranium brain model, and inflation molding simulates true tumour and supports the state for squeezing brain tissue by force, reaches simulated effect；Simulation tumour device can be arbitrary shape, type, size and location, flexibly and easily；The emulation cranium brain model is after carrying out simulation tumor resection, the reusable foundation in other positions or the simulation tumour of different size shape, can also be prepared into the cranium brain model containing multiple simulation tumour devices, achieve the effect that flexibly to can be recycled.
Description
Technical field
The present invention relates to technical field of clinical medicine, more particularly, to a kind of cranium brain model of emulation and its preparation side
Method.
Background technique
With the development of neurosurgery equipment and technology, a large amount of intracranial disease can be solved by operations on cranium and brain.
Corpse head model can provide preoperative practice condition well for operations on cranium and brain, however structure and position after the preservation of corpse head in cranium brain
It changes, is easy to deviate with true organization of human body, and corpse head quantity is reduced at present, the increase of cost, at present mostly
Several neurosurgeons fits autopsy by computer mould to carry out operative training.But many cranium brain diseases have
Specificity, corresponding operation or teaching mode or corpse is several leading is difficult truly expressed.Recently as the development of 3D printing technique,
Some tissues and organ can be realized 3D printing molding, become the important method that auxiliary doctor goes on smoothly surgical procedure.
But the material due to can be used in 3D printing directlys adopt the cortex brain tissue etc. of 3D printing acquisition there is also there is limitation
Tissue and organ model Forming Quality are poor, and its performance differs greatly with the true structure of human body and quality, can not expire
Sufficient clinical use demand.Especially for the cranium brain model containing simulation tumour device, existing cranium brain model cannot fine mould
Draw up the state of oncothlipsis surrounding tissue.Prior art CN108847111A discloses a kind of cranium brain simulation model and its preparation
The cranium brain simulation model with pliability, elasticity and sense of touch can be prepared in method, but for lesion tissues such as tumours
And the problem of being integrally formed by 3D printing, not can solve the state for simulating oncothlipsis surrounding tissue.
Therefore, a kind of cranium brain model containing simulation tumour device close with practical cranium brain structure, quality is close is developed,
The state that oncothlipsis surrounding tissue can be simulated well can be simulated in the preoperative, surgery planning or teaching rehearsal are answered
With having a very important significance.
Summary of the invention
The technical problem to be solved by the present invention is to overcome structure, the property of existing cranium brain model and true cranium brain tissue
Can the biggish defect of deviation and deficiency, a kind of cranium brain model of emulation is provided, by adding toward can pull in brain tissue cranium brain model
Enter inflatable simulation tumour device, utmostly simulates true tumour and support the state for squeezing brain tissue by force.
Another object of the present invention is to provide a kind of preparation methods of the cranium brain model of emulation.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
A kind of cranium brain model of emulation, emulation cranium brain model include containing the cranium brain model that can pull brain tissue and being set to cranium brain
Simulation tumour device inside model, the simulation tumour device are in contact with that can pull brain tissue, and simulation tumour device includes
The main body with cavity of soft material preparation, and set on the opening of body surfaces and the plugging device of occlusion of openings.
Simulation tumour device of the invention is being non-inflated condition before, and can be inserted into as needed can pull brain tissue
Target position in cranium brain model, target position are generally referred to according to tumour when the actual position of encephalic carries out three dimensional design,
Simulate corresponding position of the tumour device in cranium brain model.It is inflated by opening, and after being sealed molding with plugging device, simulation
Position of the tumour device in cranium brain model is fixed.
Existing cranium brain simulation tumour device is all the size and shape of pre-set simulation tumour, with cranium brain model one
Body printing shaping, or will first simulate the perfusion for completing brain tissue in tumour merging cranium brain model again and fill, it can not good body
The oppression state that now cranium brain tissue is gradually formed during true tumor growth.Of the invention contains the imitative of simulation tumour device
True cranium brain model is implanted into simulation tumour device inside full brain model brain tissue, can be arbitrary shape, type and the brain of position
The simulation tumour device of organization internal, simulation tumour device be can the preparation of soft material, insertion gradually fills after can pulling brain tissue
It is swollen, until reaching the form and dimension of the simulation tumour device of setting, extruding brain group can be supportted by force by simulation tumour device very well
The state knitted, achievees the effect that analogue simulation.
On the other hand, after carrying out tumor resection simulation operation, original simulation tumour device removal can be used further to next
The foundation of other positions or different size, shape simulation tumour device, achievees the effect that flexibly to can be recycled, can also be with
As needed, it is prepared into the cranium brain model containing multiple simulation tumour devices.
It is provided by the invention containing simulation tumour device emulation cranium brain model in physical structure and sense of touch with true cranium
Brain is similar, wherein can pull brain tissue has similar structure and flexibility, elasticity and drawing property with human body brain tissue height,
Can it is true to nature, intuitively reproduce cranium brain anatomical structure, and be widely used in the teaching of cranium brain structure, operations on cranium and brain simulation, training and
Operation practice.
Wherein, the cranium brain model containing the brain tissue that can be pulled of the invention is described in detail below:
Cranium brain model includes upper skull and lower skull, and the upper skull and lower skull are detachably closed connection and internal formation
Skull chamber, the skull is intracavitary to be provided with surface and pulls brain tissue with gully structure.
Wherein, the material of upper skull and lower skull is one of resin, gypsum, metal or high-temperature phase-change polymer or several
Kind, it can directly be prepared using 3D printing technique.
The material for the brain tissue that can be pulled described in preparation is preferably silicone elastomer body.Preferably, the silicone elastomer body by
Functional performed polymer and vinyl silicone oil diluent are prepared, the matter of the functionality performed polymer and vinyl silicone oil diluent
Amount is than being 1:(0.8~5), preferably 1:3.
Wherein, the functional performed polymer is the composition of silicon hydrogen organopolysiloxane and vinyl organopolysiloxane,
The mass ratio of silicon hydrogen organopolysiloxane and vinyl organopolysiloxane is (5:4)~(3:2) in the composition.
Using silicone elastomer body made from the formula, after brain tissue is made, in elasticity, flexibility, sense of touch and mechanical property
It is upper increasingly similar with true Human Cortex's brain tissue, therefore can be pulled.The brain tissue pulled is beaten by 3D
Print technology combination reperfusion mode is made.
It preferably, also include blood vessel, nerve in the cranium brain model, the blood vessel and nerve are wrapped in and described can pull
Inside brain tissue, the blood vessel and nerve are made by 3D printing.
Preferably, the wall thickness of the simulation tumour device is 0.3mm~0.8mm.Selection needs simulated operation or displaying
True tumour goes out to simulate the 3D Visualization Model of tumour device using DICOM format data reconstruction, wherein simulation tumour device
Size, shape are restored according to the image data of selected tumour, and design simulation tumour device is hollow shape, and wherein wall thickness range exists
0.3mm-0.8mm, convenient for loading inflation.
Preferably, it is described opening be reverse frustoconic, wide end outer diameter 4mm~6mm, internal diameter 3mm~5mm, narrow end outer diameter 2mm~
4mm, internal diameter 1mm~3mm.Size setting more convenient can fill in the opening plugging device and stopper.
Preferably, stopper shapes match with opening, are in rounding mesa-shaped, size, which can be slightly less than opening inside diameter, just to kiss
It runs mouth jointly, carries out closed blocking, prevent tumour simulated solution from leaking outside, more preferable simulation tumour supports by force the state for squeezing brain tissue.
Preferably, the opening passes through the sky toward simulation tumour apparatus main body for connecting tumour simulated solution filling device
Intracavitary filling tumour simulated solution forms the simulation tumour device.Tumour simulated solution can be silica gel solution or hydrogel solution,
Preferably gelatin solution, agar solution or sodium alginate soln, can be closer to the sense of touch of true tumour.
Preferably, the simulation tumour device opening is provided with class dumbbell shaped traverse latch, and the traverse latch runs through the opening
A wall so that one end of traverse latch is located at open outer side, the other end is located at opening inner side but does not close opening, and traverse latch both ends can
Inclination, wherein outboard end is for engaging card slot set by tumour simulated solution filling device.
The setting of its split shed remains for connecting tumour simulated solution filling device in advance.Simulate the cavity and opening one of tumour device
It rises and material object is obtained by 3D printing, wherein simulation tumour device cavity is printed with soft material, the soft material can be soft
Property resin material.Opening is printed with hard material, and the hard material can be hard resin material.Traverse latch both ends can slightly incline
Tiltedly, so that simulation tumour device opening can be clamped or withdraw from tumour simulated solution filling device.
Preferably, the tumour simulated solution filling device includes the sebific duct and injection device that both ends have connector, wherein the
One connector connection simulation tumour device opening, the second connector connect injection device.
Preferably, sebific duct is medical silicone tube, and the material of first interface and second interface is hard resin material, passes through 3D
Printing obtains.Sebific duct size can multiselect, internal diameter meet the >=the first connector outer diameter.
Preferably, the first connector is annular shape, wide end outer diameter of the internal diameter slightly larger than simulation tumour device opening, the first connector
Inside is provided with the card slot of engaging traverse latch.
One card slot is set on the inside of the first connector, for engaging the class dumbbell shaped traverse latch at simulation tumour device cavities open
Outboard end, snap fit are as follows: the class dumbbell shaped traverse latch outboard end of card slot and opening on the inside of the first connector coincide clamping, this
When the first connector and simulate tumour device cavity inverted round stage shaped opening be just clamped.
The outer diameter of second connector is consistent with the outer diameter of the first connector, is used to connection rubber tube, the internal diameter of the second connector according to
The size of the injection device connected determines.
Preferably, internal diameter (4.2~6.2) ± 0.2mm of the first connector, outer diameter (5.2-7.2) ± 0.2mm.
The cranium brain model containing the brain tissue that can be pulled, including skull main body, brain tissue；Skull main body includes detachable
It is closed the upper skull and lower skull of connection, the brain tissue is fixedly connected with lower skull.Preferably, it is distributed on the brain tissue
Blood vessel and nerve.
The present invention also protects the preparation method of the cranium brain model of above-mentioned emulation, includes the following steps:
S1. the cranium brain model containing the brain tissue that can be pulled is prepared；
S2. the simulation tumour device is designed and is prepared according to simulation tumour type of device, and tumour device master will be simulated
Air in body cavity drains, and obtains sheet simulation tumour device；
S3. an opening is set on containing the brain tissue that can be pulled, sheet simulation tumour device is placed on target by opening
In position, tumour simulated solution then is filled to sheet simulation tumour device, it is made to restore simulation tumour device original design shape
Shape, and with the opening simulated on tumour device is blocked, completion can pull brain tissue embedding simulation tumour device；
S4. containing the opening for the brain tissue that can be pulled and be modeled filling solidification material in the distracted gap of tumour device
Material, filling opening and gap, and solidified, obtain the emulation cranium brain model containing simulation tumour device.
Preferably, in S3., the shape of the opening of the cranium brain model containing the brain tissue that can be pulled is gap.
Preferably, in S2., the preparation method of the sheet simulation tumour device is that will simulate on tumour apparatus main body
Opening is connect by the first connector with sebific duct, and sebific duct is connect by the second connector with the first injection device for draining internal gas,
The air in simulation tumour device cavity, and extrusion simulation tumour device cavity two sides are aspirated by the first injection device, are taken out to the greatest extent
The air in tumour device cavity is simulated, sheet simulation tumour device is obtained；
S3. in, the process for pulling brain tissue embedding simulation tumour device are as follows: set containing the brain tissue that can be pulled
If an opening, sheet simulation tumour device is placed in target position by opening, it is made to be in contact with brain tissue can be pulled,
Then it changes the first injection device into the second injection device equipped with tumour simulated solution, tumour is simulated using the second injection device
Liquid is injected sheet and simulated in tumour device cavity by sebific duct makes it restore simulation tumour device original design shape and size, extracts
Second connector of sebific duct connection, plugging device is put into sebific duct, connects the second connector, and second that the second connector is connected again
Injection device gains pneumatic first injection device, pushes plugging device to fill in opening with the first injection device for being filled air
Closed simulation tumour device, while plugging device touches traverse latch and to release between simulation tumour device opening and the first connector of sebific duct
Clamping, sebific duct and the first connector can be withdrawn from this time, completion can pull brain tissue embedding simulation tumour device.Wherein, containing can lead
The cranium brain model of the brain tissue of drawing it is specific the preparation method is as follows:
S11. the upper skull and lower skull of detachable closure connection are prepared by 3D printing technique；
S12. preparing can be with the cortex brain tissue mold of the lower skull closure connection, and the brain tissue mold has and brain
The opposite concaveconvex structure in the gully of tissue；
S13. the brain tissue mold and the closure connection of lower skull are formed into cavity, and silica gel bullet is perfused into the cavity
Property body, after solidification remove brain tissue mold, obtain the cranium brain model containing brain tissue.
Preferably, in S11., blood vessel and nerve are fixed on lower skull.
Tumour simulated solution of the invention is the aqueous solution of the substances such as gelatin, sodium alginate, agar, mass fraction is 5%~
40%, preferably 20%.It can be adjusted according to physical simulation tumour device.
In order to realize better tumour simulated solution filling effect, concrete operations can be with are as follows: is drawn using the second injection device
Tumour simulated solution, replacing former the first injection device for being filled air connecting with the second connector, (suction simulation tumour device is empty
Injection device after the air of chamber), simulation tumour device cavity is injected by sebific duct from the second injection device tumour simulated solution
In, when simulation tumour device cavity almost fills, that is, 80~90% content is perfused, when specific volume can be according to design
The volume for simulating tumour device cavity calculates, and extracts the second connector of sebific duct connection, plugging device is put into sebific duct, is connected again
Second connector, and the second injection device is gained into pneumatic first injection device, with the first injection device for being filled air
Tumour simulated solution remaining in sebific duct is promoted in simulation tumour device cavity together, reaches glue liquid in pipe and be fully advanced simulation
Tumour device cavity, is completely filled in cavity full, and simulation tumour device restores former design shape and size.At this point, plugging device
Closure of openings simulation tumour device is filled in, while plugging device touches traverse latch and to release simulation tumour device opening and sebific duct first
Clamping between connector, can withdraw from sebific duct and the first connector at this time, and completion can pull brain tissue embedding simulation tumour device, avoid
Stretch out one's hand can pull disassemble that the first connector causes to simulate tumour setting position in brain tissue move or fill with tumour simulated solution
Cavity breakage risk.
Wherein the effect of plugging device is to be to be pushed into seal tumour simulated solution up for safekeeping when simulation tumour device opening, together
Shi Shixian presses down traverse latch (dumbbell shaped) inner end, so that outboard end is upturned to release simulation tumour device opening and glue
Clamping between the first connector of pipe, it is convenient with connecting tube and the first connector is withdrawn from.
After sebific duct is withdrawn from, in order to preferably eliminate opening and gap, in the opening of the brain tissue originally cut and by
It simulates in the distracted gap of tumour device, fills silica gel solution identical with brain tissue can be pulled, then place baking oven low-heat and dry 2
~4h completes the solidification of opening adhesion, and the opening that can pull brain tissue is eliminated, and it is whole outer that recovery can completely pull brain tissue
It sees.Upper skull and lower skull closure are connected, the cranium brain model is obtained.
Compared with prior art, the beneficial effects of the present invention are:
(1) the cranium brain model of emulation of the invention can pull in brain tissue place the simulation tumour device with cavity after it is past
Cavity filling tumour simulated solution is formed by simulation tumour device, can simulate tumour device and support the state for squeezing brain tissue by force,
Achieve the effect that analogue simulation.
(2) simulation tumour device of the invention can be simulation arbitrary shape, type, size and location brain tissue inside
Tumour, without in advance fixed setting, it is more flexible and convenient.
(3) of the invention containing the cranium brain model of brain tissue can be pulled after carrying out tumor resection simulation operation, it is reusable in
Other next positions or different size, the foundation of the simulation tumour device of shape, also can according to need, are prepared into containing multiple
The cranium brain model for simulating tumour device, achievees the effect that flexibly to can be recycled.
(4) the emulation cranium brain model brain tissue containing simulation tumour device of the invention can pull, utmostly mould
The elasticity and sense of touch of true brain tissue are intended.
Detailed description of the invention
Fig. 1 is the overall structure figure for simulating tumour device.
Fig. 2 is the cross section structure schematic diagram for simulating tumour device.
Fig. 3 is first interface structural schematic diagram.
Fig. 4 is second interface connection rubber tube end structure schematic diagram.
Fig. 5 is that second interface connects injection device end structure schematic diagram.
Fig. 6 is second interface structural profile illustration.
Fig. 7 is emptying and the inflation operations schematic diagram for simulating tumour device.
Fig. 8 is cranium brain model structure.
Fig. 9 is that can pull brain tissue opening Local map.
Specific embodiment
The present invention is further illustrated With reference to embodiment, but embodiment the present invention is not done it is any
The restriction of form.Unless otherwise indicated, source chemicals used in the embodiment of the present invention are the source chemicals routinely bought.
Embodiment 1
A kind of cranium brain model of emulation, emulation cranium brain model include containing the cranium brain model that can pull brain tissue and being set to cranium brain
Simulation tumour device inside model, simulation tumour device are in contact with that can pull brain tissue, and simulation tumour device includes soft
Material preparation the main body with cavity and set on the opening 1 of body surfaces and the plugging device 2 of occlusion of openings.
Selection needs the true tumour of simulated operation or displaying, goes out to simulate tumour device using DICOM format data reconstruction
3D Visualization Model, wherein form and dimension according to the image data of the tumour of selected simulation restore, design simulation tumour dress
It is set to hollow shape, the wall thickness of simulation tumour device is 0.3mm, and opening 1 is for extensive again after air in emptying simulation tumour device
For simulation tumour device to former design shape and size, plugging device is used for closed simulation tumour device, and is repaired with silica gel solution again
Brain tissue opening can be pulled, the emulation cranium brain model containing simulation tumour device is obtained.
The cavity and opening for simulating tumour device obtain material object by 3D printing together, wherein simulation tumour device cavity is used
Soft resin file printing, opening hard resin file printing.
Embodiment 2
A kind of cranium brain model of emulation, emulation cranium brain model include containing the cranium brain model that can pull brain tissue and being set to cranium brain
Simulation tumour device inside model, simulation tumour device are in contact with that can pull brain tissue, and simulation tumour device includes soft
Material preparation the main body with cavity and set on the opening 1 of body surfaces and the plugging device 2 of occlusion of openings, the opening is used for
Tumour simulated solution filling device is connected, it is swollen to restore simulation by filling tumour simulated solution in simulation tumour device institute band cavity
Tumor device original design shape and size.
Selection needs the true tumour of simulated operation or displaying, goes out to simulate tumour device using DICOM format data reconstruction
3D Visualization Model, wherein size shape according to the image data of the tumour of selected simulation restore, design simulation tumour device
For hollow shape, the wall thickness for simulating tumour device is 0.3mm, and traverse latch 3 is additionally provided at opening 1, and traverse latch 3 is class dumbbell shaped, traverse latch 3
Through a wall of opening 1, so that one end of traverse latch is located at open outer side, the other end is located at opening inner side but does not close opening,
3 both ends tiltable of traverse latch, opening 1 is for connecting tumour simulated solution filling device, and traverse latch 3 is for engaging tumour simulated solution filling dress
Set set card slot.
The body cavity and opening 1 for simulating tumour device obtain material object by 3D printing together, wherein simulation tumour device
Cavity is printed with soft material, and opening 1 is printed with hard material.Opening 1 is reverse frustoconic, and wide end outer diameter 4mm, internal diameter 3mm are narrow
Outer diameter 2mm, internal diameter 1mm are held, plugging device 2 is to be dimensioned slightly smaller than the internal diameter of opening 1 in rounding mesa-shaped, and traverse latch 3 is class dumbbell shaped,
Tumour simulated solution filling device includes the sebific duct 4 and injection device 5 that both ends have connector, and the first connector 6 is annular shape, and internal diameter omits
Greater than wide end outer diameter, inside is additionally provided with the card slot 7 of engaging traverse latch, the first connector 6 connection opening 1, the connection injection of the second connector 8
Device 5,5.2 ± 0.2mm of internal diameter of the first connector 6,6.2 ± 0.2mm of outer diameter.
The outer diameter of second connector 8 is consistent with the outer diameter of the first connector 6, is used to connection rubber tube 4, the internal diameter of the second connector 8
It is determined according to the size of the injection device for injecting tumour simulated solution.
Sebific duct 4 is medical silicone tube, and the effect of sebific duct 4 aspirates empty intracavity gas for connection injection device and swells to simulation
The cavity of tumor device is passed through tumour simulated solution, and the material of first interface and second interface is hard resin material, passes through 3D printing
It obtains.4 size of sebific duct can multiselect, internal diameter meet the >=the first connector outer diameter.
Card slot 7 is used to engage the outboard end of the class dumbbell shaped traverse latch at simulation tumour device cavities open 1, snap fit
Are as follows: the card slot of 6 inside of the first connector and the just identical clamping of class dumbbell shaped traverse latch outboard end at simulation tumour device opening 1,
That is the inverted round stage shaped opening 1 of the first connector 6 and simulation tumour device cavity is clamped.
Embodiment 3
A kind of preparation method of the emulation cranium brain model containing simulation tumour device, includes the following steps:
S1. the cranium brain model containing the brain tissue that can be pulled is prepared；
S2. it is designed according to simulation tumour type of device and prepares the simulation tumour apparatus main body with cavity and be set to master
The opening and plugging device in body surface face drain the air simulated in tumour apparatus main body cavity, obtain sheet simulation tumour device；
S3. containing the brain tissue upper opening that can be pulled, sheet simulation tumour device is placed on target position by gap
In, then to sheet simulation tumour device be filled tumour simulated solution, make its restore simulation tumour device original design shape and
Size, with plugging device occlusion of openings, completion can pull brain tissue embedding simulation tumour device；
S4. it in the gap on cranium brain model and is modeled in the distracted gap of tumour device and inserts curing materials, fill
Gap and gap obtain the emulation cranium brain model containing simulation tumour device.
The cranium brain model of the brain tissue that can be pulled it is specific the preparation method is as follows:
The upper skull and lower skull that detachable closure connection is prepared by 3D printing technique, preferably include blood vessel and mind
Through medium vessels and nerve are fixedly connected with lower skull；
Preparation can be with the cortex brain tissue mold of the lower skull closure connection, and the brain tissue mold has and brain tissue
The opposite concaveconvex structure in gully；
The brain tissue mold and the closure connection of lower skull are formed into cavity, and silicone elastomer is perfused into the cavity
Body removes brain tissue mold after solidification, obtain containing the cranium brain model that can pull brain tissue, at this point, blood is distributed with inside brain tissue
Pipe and nerve.
Embodiment 4
A kind of preparation method of the cranium brain model of emulation, includes the following steps:
S1. the cranium brain model containing the brain tissue that can be pulled is prepared；
S2. simulation tumour device of the preparation with cavity is designed according to tumor type, the air in tumour device will be simulated and arranged
To the greatest extent, sheet simulation tumour device is obtained, sheet simulates the preparation process concrete operations of tumour device are as follows: simulation tumour apparatus main body
On opening be clamped by the first connector and sebific duct, sebific duct is connected by the second connector with the first injection device for draining internal gas
It connects, the air in simulation tumour device cavity, and extrusion simulation tumour device cavity two sides is aspirated by the first injection device, are taken out
The air in tumour device cavity is simulated to the greatest extent, obtains sheet simulation tumour device；
S3. the process that brain tissue embedding simulation tumour device can be pulled are as follows: set being set containing the brain tissue that can be pulled
Sheet simulation tumour device is placed in target position by opening, so that it is in contact with that can pull brain tissue, so by one opening
The first injection device is changed into the second injection device equipped with tumour simulated solution afterwards, using the second injection device tumour simulated solution
Injecting sheet by sebific duct and simulate in tumour device cavity makes it restore simulation tumour device original design shape and size, extracts glue
Second connector of pipe connection, plugging device is put into sebific duct, connects the second connector, and the second note that the second connector is connected again
Injection device gains pneumatic first injection device, pushes plugging device to fill in opening with the first injection device for being filled air close
Die closing intends tumour device, while plugging device touches traverse latch and to release between simulation tumour device opening and the first connector of sebific duct
Clamping, can withdraw from sebific duct and the first connector at this time, and completion can pull brain tissue embedding simulation tumour device.
S4. after sebific duct is withdrawn from, in order to preferably eliminate gap and gap, on the gap of the brain tissue originally cut and
It is modeled in the distracted gap of tumour device, fills silica gel solution identical with brain tissue can be pulled, then place baking oven low-heat
2-4h is dried, the solidification of gap adhesion is completed, the gap that can pull brain tissue is eliminated, and it is whole outer that recovery can completely pull brain tissue
It sees.Upper skull and lower skull closure are connected, the cranium brain model is obtained.
Tumour simulated solution is the aqueous solution of gelatin, mass fraction 20%.
The cranium brain model of the brain tissue that can be pulled it is specific the preparation method is as follows:
The upper skull and lower skull that detachable closure connection is prepared by 3D printing technique, preferably include blood vessel and mind
Through medium vessels and nerve are fixedly connected with lower skull；
Preparation can be with the cortex brain tissue mold of the lower skull closure connection, and the brain tissue mold has and brain tissue
The opposite concaveconvex structure in gully；
The brain tissue mold and the closure connection of lower skull are formed into cavity, and silicone elastomer is perfused into the cavity
Body removes brain tissue mold after solidification, obtain containing the cranium brain model that can pull brain tissue, at this point, blood is distributed with inside brain tissue
Pipe and nerve.
Obviously, the above embodiment of the present invention be only to clearly illustrate example of the present invention, and not be pair
The restriction of embodiments of the present invention.For those of ordinary skill in the art, may be used also on the basis of the above description
To make other variations or changes in different ways.There is no necessity and possibility to exhaust all the enbodiments.It is all this
Made any modifications, equivalent replacements, and improvements etc., should be included in the claims in the present invention within the spirit and principle of invention
Protection scope within.
Claims (10)
1. a kind of cranium brain model of emulation, emulation cranium brain model includes containing the cranium brain model that can pull brain tissue and being set to cranium brain mould
Simulation tumour device inside type, which is characterized in that the simulation tumour device is in contact with that can pull brain tissue, simulates tumour
Device include soft material preparation the main body with cavity and set on the opening of body surfaces and the plugging device of occlusion of openings.
2. the cranium brain model emulated as described in claim 1, which is characterized in that the wall thickness of the simulation tumour device is 0.3mm
~0.8mm.
3. the cranium brain model emulated as described in claim 1, which is characterized in that the opening is reverse frustoconic, wide end outer diameter 4mm
~6mm, internal diameter 3mm~5mm, narrow end outer diameter 2mm~4mm, internal diameter 1mm~3mm；The plugging device is to match with the opening
Rounding mesa-shaped.
4. the cranium brain model emulated as described in claim 1, which is characterized in that described logical containing the cranium brain model that can pull brain tissue
Crossing 3D printing technique combines perfusion to be made.
5. the cranium brain model emulated as described in claim 1, which is characterized in that the opening is for connecting the filling of tumour simulated solution
Device forms the simulation tumour device by filling tumour simulated solution in the cavity of simulation tumour apparatus main body.
6. the cranium brain model emulated as claimed in claim 5, which is characterized in that the simulation tumour device opening is provided with class
Dumbbell shaped traverse latch, traverse latch run through a wall of the opening, so that one end of traverse latch is located at open outer side, the other end is located at opening
Inside but opening is not closed, the tiltable of traverse latch both ends, wherein outboard end is for engaging card slot set by tumour simulated solution filling device.
7. the cranium brain model emulated as claimed in claim 6, which is characterized in that the tumour simulated solution filling device includes both ends
Sebific duct and injection device with connector, the first connector of the sebific duct are annular shape, and internal diameter is slightly larger than simulation tumour device
Be open wide end outer diameter, and inside is provided with the card slot of engaging simulation tumour device opening traverse latch, and the first connector of the sebific duct connects
The opening of simulation tumour device is connect, the second connector of the sebific duct connects injection device.
8. the cranium brain model of the emulation as described in claim 1~7 any one, which is characterized in that the emulation cranium brain model is
By being first made containing the cranium brain model that can pull brain tissue, sky then is built into containing the cranium brain model that can pull brain tissue to described
Simulation tumour device, then injection tumour simulated solution is prepared into empty simulation tumour device.
9. a kind of preparation method of the cranium brain model of emulation described in claim 1~8 any one, which is characterized in that including such as
Lower step:
S1. the cranium brain model containing the brain tissue that can be pulled is prepared；
S2. the simulation tumour device is designed and prepared according to the target tumor of simulation, and will simulate tumour apparatus main body cavity
Interior air drains, and obtains sheet simulation tumour device；
S3. an opening is set on the brain tissue that can be pulled, and sheet simulation tumour device is placed in target position by opening,
Then tumour simulated solution is filled to sheet simulation tumour device, it is made to restore simulation tumour device original design shape and big
It is small, and the opening on simulation tumour device is blocked, completion can pull brain tissue embedding simulation tumour device；
S4. it in the opening for the brain tissue that can be pulled and is modeled in the distracted gap of tumour device filling and brain tissue can be pulled
Identical silica gel solution, filling opening and gap, and solidified, obtain the emulation cranium brain mould containing simulation tumour device
Type.
10. the preparation method of the cranium brain model emulated as claimed in claim 9, which is characterized in that
S2. in, the preparation method of the sheet simulation tumour device is that will simulate the opening on tumour apparatus main body to pass through first
Connector is in clamping connection with sebific duct, and the second connector of sebific duct is connect with the first injection device, swollen by the suction simulation of the first injection device
The air of tumor device cavity, and extrusion simulation tumour device cavity two sides are taken out the air simulated to the greatest extent in tumour device cavity, are obtained
Sheet simulates tumour device；
S3. in, the process for pulling brain tissue embedding simulation tumour device are as follows: set one setting containing the brain tissue that can be pulled
Sheet simulation tumour device is placed in target position by opening, so that it is in contact with that can pull brain tissue, then by opening
It changes the first injection device into the second injection device equipped with tumour simulated solution, tumour simulated solution is led to using the second injection device
Crossing in sebific duct injection sheet simulation tumour device cavity makes it restore simulation tumour device original design shape and size, extracts sebific duct
Second connector of connection, plugging device is put into sebific duct, connects the second connector again, and the second of the connection of the second connector is injected
Device gains pneumatic first injection device, pushes plugging device to fill in opening with the first injection device for being filled air closed
Tumour device is simulated, while plugging device touches traverse latch and to release the clamping between simulation tumour opening and the first connector of sebific duct,
Sebific duct and the first connector can be withdrawn from this time, and completion can pull brain tissue embedding simulation tumour device.
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