JP4297648B2 - Lecithin aqueous dispersion composition and aqueous cosmetic using the same - Google Patents
Lecithin aqueous dispersion composition and aqueous cosmetic using the same Download PDFInfo
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- JP4297648B2 JP4297648B2 JP2002148503A JP2002148503A JP4297648B2 JP 4297648 B2 JP4297648 B2 JP 4297648B2 JP 2002148503 A JP2002148503 A JP 2002148503A JP 2002148503 A JP2002148503 A JP 2002148503A JP 4297648 B2 JP4297648 B2 JP 4297648B2
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- lecithin
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- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 title claims description 66
- 239000000787 lecithin Substances 0.000 title claims description 51
- 235000010445 lecithin Nutrition 0.000 title claims description 51
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Description
【０００１】
【発明の属する技術分野】
本発明は、長時間にわたり沈殿物等を生じ難く安定性に優れたレシチン水分散組成物及びこれを用いた水性化粧料に関する。
【０００２】
【従来の技術】
リン脂質を水に分散させるとラメラ構造を有したリポソームを形成することが知られている。リポソームは中心部に水相を有し、水溶性物質を内包できることから、ドラッグデリバリーシステム（ＤＤＳ）として医薬品への応用が検討されている。また、その使用感や保湿性等から化粧品への応用も検討されている。
一方、化粧水、美容液等の水性化粧料には、一般的に水溶性の生理活性物質が含有している。また、化粧料の原料として使用されるリン脂質は、酸化され難い飽和型のリン脂質が使用されており、このようなリン脂質として水素添加処理を施した精製レシチン（以下、単に「水素添加レシチン」という）が一般的に使用されている。
【０００３】
しかしながら、化粧料で一般的に使用されている量の生理活性物質を含有した水溶液に水素添加レシチンを分散させた場合、製造後数日程度で水素添加レシチンの沈殿を生じ、安定性で問題があった。そのため、レシチン分散液においては、沈殿物が生じないように、極僅かな生理活性物質しか含有させることが出来なかった。その原因を調べたところ、化粧料に使用されている水溶性の生理活性物質は、化粧料全体の導電性を高め、かつその透過率を下げる傾向があり、これらが水分散した水素添加レシチンの安定性を損なわさせていることが分った。
そこで、安定性を改善するために化粧料で一般的に使用されている非イオン性界面活性剤との組合わせを検討した。
【０００４】
既に、レシチンと非イオン性界面活性剤との組合わせについては、いくつか提案されている。例えば、特開昭６２−９５１３４号公報には、レシチンと親水性の非イオン性界面活性剤とを水に分散させたリポソームの製造方法が既に開示されている。しかし、この公報は、リポソームの大量調製を目的とし、実施例においては、単に、レシチンと非イオン界面活性剤の組合わせたものを水に分散させた例しか開示されていない。また、開示されている非イオン性界面活性剤は、主にポリオキシエチレン系あるいはポリエチレングリコール系の非イオン性界面活性剤であり、これを化粧料で一般的に使用されている水素添加レシチンと組合わせて、水溶性の生理活性物質が含有した水性化粧料に応用した場合、若干、安定性が改善されるものの、化粧料全体の導電性が高まり、かつその透過率が下がるので、依然として保存中に沈殿物を生じ、満足できるものでなかった。
【０００５】
また、特開昭６１−１６７６１０号公報には、水溶性の生理活性物質であるムコ多糖とレシチンを含有した化粧料が開示されおり、その実施例では、非イオン性界面活性剤としてポリオキシエチレン硬化ヒマシ油（オキシエチレンが６０モル）を含有した化粧水が例示されている。
しかしながら、ここで開示されている化粧水は、水素添加処理を施していない精製レシチンを使用していることから、保存中に精製レシチンが酸化し異臭を発するという問題があった。また、ここで開示されている化粧水は、精製レシチンに対し５０倍量のポリオキシエチレン硬化ヒマシ油を使用していることから、６６０ｎｍにおける透過率が９０％以下である本願発明のレシチン水分散組成物と異なる透明タイプの組成物であり、その使用感もべとつくという問題があった。仮に、精製レシチンに換えて水素添加レシチンを用い、透過率が９０％以下となるようにポリオキシエチレン硬化ヒマシ油の含有量を減らした場合、ムコ多糖により化粧料全体の導電性が高いことから、その透過率が下がるので、上述した特開昭６２−９５１３４号公報のリポソームを応用した化粧料と同様、保存中に沈殿物を生じた。
【０００６】
以上要するに、従来技術においてもムコ多糖等の水溶性の生理活性物質を通常の使用量（有効量）含有させたレシチン水分散組成物及びこれを用いた水性化粧料の試作は可能であった。しかし、このような組成物や化粧料は、生理活性物質を含有させることにより電気伝導度が０．５ｍＳ／ｃｍ以上で、かつ６６０ｎｍにおける透過率が９０％以下となり、その結果、保存中に沈殿物等を生じて安定性に欠けるため、実用上の価値がないことが分かった。
【０００７】
【発明が解決しようとする課題】
このような状況下、本発明は電気伝導度を上げる水溶性の生理活性物質等を通常の使用量含有させても長時間にわたり沈殿物等を生じ難い安定性の優れたレシチン水分散組成物及びこれを用いた水性化粧料を提供することを目的とする。
【０００８】
【課題を解決するための手段】
その目的を達成するため、本発明者等は種々研究の結果、親水性の非イオン性界面活性剤のうちでもポリグリセリン脂肪酸エステルを用いればその目的が達成できるとの知見に至り、本発明を完成したものである。
本発明は、
（１）水素添加レシチンと、水溶性生理活性物質であるヒアルロン酸ナトリウム０．０１〜１％（乾物換算）、酵母抽出液０．１〜５％、又は海草抽出液０．１〜５％とを含有し、電気伝導度が０．５ｍＳ／ｃｍ以上、かつ、６６０ｎｍおける透過率が９０％以下であり、水素添加レシチンに対し油性成分が０．５倍量以下である水性化粧料用のレシチン水分散組成物であって、ＨＬＢが１０以上のポリグリセリン脂肪酸エステルを含有してなるレシチン水分散組成物、
（２）（１）のレシチン水分散組成物を配合してなる水性化粧料、
からなるものである。
【０００９】
【発明の実施の形態】
以下、本発明を詳説する。なお、本発明において「％」は「質量％」を、「部」は「質量部」を意味する。
本発明においてレシチン水分散組成物とは、水素添加レシチンに対し油性成分（例えば、脂溶性ビタミン、動植物油、加工油等の油脂類）が０．５倍量以下の割合で水に分散させたもので、その電気伝導度が０．５ｍＳ／ｃｍ以上で、６６０ｎｍにおける透過率が９０％以下の液状体である。
ここで、電気伝導度は、２０℃における本発明のレシチン水分散組成物を導電率計（（株）堀場製作所製「カスタニーLAB導電率計DS-14」）で測定した値である。また６６０ｎｍにおける透過率はレシチン分散組成物を室温（２０℃）にして分光光度計（波長６６０ｎｍ）にて測定した値をいう。
【００１０】
また、水性化粧料とは、レシチン水分散組成物を含有させた化粧料であり、クリーム、乳液以外の例えば、化粧水、美容液等の水溶性原料を主成分とした液状乃至ジェル状の化粧料である。水性化粧料の電気伝導度が０．５ｍＳ／ｃｍ以上のものは、沈殿物を生じやすいことから、本発明が特に好適である。なお、本発明では、レシチン水分散組成物をそのまま水性化粧料として用いてもよく、水性化粧料全体に対し１〜１００％のレシチン分散組成物を配合させるとよい。
【００１１】
また、本発明で用いられる水素添加レシチンとは、卵黄、大豆等の天然物から抽出あるいは分画した精製レシチン（ジアシル型のリン脂質を主成分としたもの）に水素添加処理を施しリン脂質の構成脂肪酸を飽和型となるように処理したものである。具体的には、不飽和の度合いを示すヨウ素価が３０以下（化粧品原料基準第二版「ヨウ素価測定法」）のものであり、上述の酸化安定性の点でヨウ素価が１０以下のものが好ましい。また、水素添加レシチンのヨウ素価が低くなるにつれ、電気伝導度が高い水に分散させた場合、沈殿物を生じやすいことから、ヨウ素価１０以下のものが本発明に好適である。
その含有量は、化粧料に含有させた場合の使用感や保湿性の点で、レシチン水分散組成物全体に対して０．０１〜５％が好ましく、０．０５〜３％がより好ましい。
本発明のレシチン水分散組成物に使用する水素添加レシチンとしては、安定性の点で、卵黄由来の水素添加レシチンが好ましい。
ここで、水素添加レシチンを用いるのは、化粧料は通常、室温で長期間使用されることから、酸化による異臭や褐変が起き難くするためである。
【００１２】
また、本発明で用いられるポリグリセリン脂肪酸エステルとは、グリセリンを重合させたポリグリセリンに脂肪酸をエステル結合させたものである。市販されているものとしては、グリセリンの平均重合度が２〜１０まで各種あり、グリセリンの重合度、脂肪酸の種類、そのエステル化の度合いにより非常に多くの種類がある。
本発明に使用するポリグリセリン脂肪酸エステルは、市販されているものであれば何れでも良いが、ＨＬＢ（親水性親油性バランス）が１０以上のものが、本発明の効果の点で好ましい。
この物質の本発明のレシチン水分散組成物への配合量は、本発明の効果の点で本発明で用いる水素添加レシチンに対し好ましくは０．０５〜３倍量、より好ましくは０．１〜１．５倍量である。
【００１３】
さらに、本発明においてレシチン水分散組成物や水性化粧料に通常の使用量含有させた場合、電気伝導度を上げる物質としては、水溶性の生理活性物質等があり、例えば、ヒアルロン酸、コンドロイチン硫酸、ピロリドンカルボン酸及びその塩、コラーゲン、酵母抽出液、海草抽出液、各種アミノ酸やペプチド及びその混合物、α−ヒドロキシ酸、アスコルビン酸リン酸エステル、アスコルビン酸硫酸エステル、塩酸ピリドキシン、パントテン酸及びその塩等の水溶性ビタミン類等、また、水溶液が酸性もしくはアルカリ性を示す為中和が必要となるもの例えば、アスコルビン酸２-グルコシド、カルボキシビニルポリマー等の物質が挙げられる。
ここで通常の使用量とは、含有させる物質によって異なるが、例えば、ヒアルロン酸ナトリウムの場合、全体に対して０．０１〜１％（乾物換算）、酵母抽出液の場合０．１〜５％、海草抽出液の場合０．１〜５％程度である。
【００１４】
本発明のレシチン水分散組成物の製造方法は、従来の工業規模でのリポソーム調製方法に従って製造すれば良く、例えば、各成分を精製水等の水に分散、さらに必要に応じ加熱した後、高圧ホモゲナイザーで処理する方法等が挙げられる。また、本発明のレシチン水分散組成物を用いた水性化粧料の製造方法は、例えば、レシチン水分散組成物と他の水性原料を含有した水溶液とを混合するすれば良い。
【００１５】
本発明のレシチン水分散組成物及び水性化粧料は、本発明の効果を損なわない範囲で他の化粧品原料を含有させることができる。例えば、1,3-ブチレングリコール、プロピレングリコール、グリセリン、イソプレングリコール、ペンチレングリコール等の多価アルコール、エタノール、イソプロパノール等の低級アルコール、パラベン、フェノキシエタノール等の防腐剤、乳化剤、香料、色素等が挙げられる。
【００１６】
本発明のレシチン水分散組成物及びこれを用いた水性化粧料は、親水性の非イオン性界面活性剤としてポリグリセリン脂肪酸エステルを含有させたので、電気伝導度を上げる水溶性の物質を通常の使用量用いてその電気伝導度を０．５ｍＳ／ｃｍ以上、かつ６６０ｎｍにおける透過率を９０％以下にしても、後述の実施例にも示すように、保存中に分離や沈殿物が生じることなく安定である。
【００１７】
【実施例】
［実施例１］、［比較例１］及び［比較例２］
表１に示す原料と配合割合でそれぞれ比較例１、比較例２及び実施例１のレシチン水分散組成物を試作した。
具体的には、まずＡ相の各原料とＢ相の各原料とを別個にそれぞれ混合し、７０℃に加温して均一したところで、次に、Ａ相の溶液にＢ相の溶液を加えて粗分散させ、最後に、高圧乳化機を用いて圧力３０，０００ｐｓｉで処理してレシチン水分散組成物を得た。
【００１８】
なお、得られたいずれのレシチン水分散組成物も、性状が液状であり、電気伝導度が０．５ｍＳ／ｃｍ以上、６６０ｎｍの透過率が９０％以下であった。
また、原料として使用した水素添加精製卵黄レシチンは、ヨウ素価が１０以下であり、ポリグリセリン脂肪酸エステル及びポリオキシエチレン硬化ヒマシ油は、ＨＬＢが１０以上のものを使用した。
上記各レシチン水分散組成物をガラスびんに充填・密封し同じサンプルについて３びんずつ作成し、これをそれぞれ４℃，４０℃及び室温（２０℃）に６０日間保存した後、各サンプルの状態を観察したところ表１の結果が得られた。
【００１９】
【表１】
表１より、親水性の非イオン性界面活性剤としてポリグリセリン脂肪酸エステルを用いると保存中に分離や沈殿物の生じない安定なレシチン水分散組成物が得られることが理解できる。
【００２１】
［実施例２］
表２に示す原料と配合割合で、実施例１と同じ方法でレシチン水分散組成物を試作した。
なお、得られたレシチン水分散組成物は、性状がジェル状であり、電気伝導度が０．５ｍＳ／ｃｍ以上、６６０ｎｍの透過率が９０％以下であった。
また、原料として使用した水素添加精製卵黄レシチンは、ヨウ素価が１０以下であり、ポリグリセリン脂肪酸エステルは、ＨＬＢが１０以上ものを使用した。
上記レシチン水分散組成物について実施例１と同じ保存テストをしたところ、表２の結果が得られた。
【００２２】
【表２】
表２より、水溶性の生理活性物質として実施例１の海草抽出液に代えて酵母抽出液を用いても、保存中に分離や沈殿物の生じない安定なレシチン水分散組成物が得られることが理解できる。
なお、酵母抽出液に代えてヒアルロン酸ナトリウム（配合量０．２％）を用いてレシチン水分散組成物を試作したが、上記と同様の結果が得られた。
【００２４】
［実施例３］
下記の原料を用意した。
次に、実施例１の水分散組成物以外の原料を精製水に溶解させた後、これと実施例１のレシチン水分散組成物とを混合し、液状の化粧水を製した。
得られた化粧水は、使用感及び保湿性に優れ、また長期間にわたり沈殿物等を生じず安定であった。
なお、得られた化粧水は、電気伝導度が、０．５ｍＳ／ｃｍ以上、６６０ｎｍの透過率は９０％以下であった。
【００２６】
［実施例４］
下記原料を用意した。
次に、メチルパラベンを溶解させた精製水にカルボキシビニルポリマーを分散後、水酸化カリウムでｐＨ７．０に調整し、この溶液に実施例２のレシチン水分散組成物以外の原料を溶解させた後、これと実施例２の水分散組成物と混合し、ジェル状の美容液を製した。
得られた美容液は、使用感及び保湿性に優れ、また長期間にわたり沈殿物等を生じず安定であった。
得られた美容液は、電気伝導度が、０．５ｍＳ／ｃｍ以上、６６０ｎｍの透過率は９０％以下であった。
なお、ヒアルロン酸ナトリウムを用いたレシチン水分散組成物を原料として、上記と同じジェル状の美容液を試作してみたが、上記と同様の結果が得られた。
【発明の効果】
以上述べたように、本発明のレシチン水分散組成物及びこれを用いた水性化粧料は、電気伝導度を上げる水溶性の生理活性物質等を通常の使用量含有させても長時間にわたり沈殿等が生じず安定である。したがって、本発明によれば、使用感や保湿性に優れた新しいタイプの化粧料を提供することができる。[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a lecithin aqueous dispersion composition that is less likely to cause precipitation or the like over a long period of time and has excellent stability, and an aqueous cosmetic using the same.
[0002]
[Prior art]
It is known that when a phospholipid is dispersed in water, a liposome having a lamellar structure is formed. Liposomes have an aqueous phase in the center and can encapsulate water-soluble substances. Therefore, application to pharmaceuticals as drug delivery systems (DDS) has been studied. In addition, its application to cosmetics is also being studied because of its feeling of use and moisture retention.
On the other hand, aqueous cosmetics such as skin lotions and cosmetic liquids generally contain water-soluble physiologically active substances. Moreover, saturated phospholipids that are difficult to oxidize are used as raw materials for cosmetics, and purified lecithin (hereinafter simply referred to as “hydrogenated lecithin”) that has been subjected to hydrogenation treatment as such phospholipid. ") Is commonly used.
[0003]
However, when hydrogenated lecithin is dispersed in an aqueous solution containing a physiologically active substance in an amount generally used in cosmetics, hydrogenated lecithin precipitates within a few days after production, which causes problems with stability. there were. Therefore, in the lecithin dispersion, only a very small amount of physiologically active substance could be contained so that no precipitate was formed. As a result of examining the cause, water-soluble physiologically active substances used in cosmetics tend to increase the overall conductivity of the cosmetics and lower its permeability, and these are water-dispersed hydrogenated lecithins. It was found that the stability was impaired.
Then, in order to improve stability, the combination with the nonionic surfactant generally used by cosmetics was examined.
[0004]
Several combinations of lecithin and nonionic surfactant have already been proposed. For example, JP-A-62-95134 has already disclosed a method for producing liposomes in which lecithin and a hydrophilic nonionic surfactant are dispersed in water. However, this publication aims to prepare a large amount of liposomes, and in the Examples, only an example in which a combination of lecithin and a nonionic surfactant is dispersed in water is disclosed. Further, the disclosed nonionic surfactant is mainly a polyoxyethylene-based or polyethylene glycol-based nonionic surfactant, which is a hydrogenated lecithin generally used in cosmetics. When combined and applied to aqueous cosmetics containing water-soluble physiologically active substances, although the stability is slightly improved, the conductivity of the entire cosmetics is increased and its transmittance is lowered, so it is still preserved. A precipitate formed inside and was not satisfactory.
[0005]
JP-A-61-167610 discloses a cosmetic containing mucopolysaccharide and lecithin, which are water-soluble physiologically active substances. In the examples, polyoxyethylene is used as a nonionic surfactant. The lotion containing hydrogenated castor oil (60 mol of oxyethylene) is illustrated.
However, since the lotion disclosed here uses purified lecithin that has not been subjected to hydrogenation treatment, there is a problem that the purified lecithin oxidizes during storage and gives off an odor. Further, the lotion disclosed here uses polyoxyethylene hydrogenated castor oil 50 times as much as purified lecithin, and therefore the lecithin water dispersion of the present invention having a transmittance at 660 nm of 90% or less. There is a problem that it is a transparent type composition different from the composition and its feeling of use is sticky. If hydrogenated lecithin is used instead of purified lecithin and the content of polyoxyethylene hydrogenated castor oil is reduced so that the transmittance is 90% or less, the mucopolysaccharide has high electrical conductivity of the entire cosmetic. Since the transmittance decreased, a precipitate was formed during storage, similar to the cosmetics to which the liposome described in JP-A-62-95134 described above was applied.
[0006]
In short, even in the prior art, it was possible to prototype a lecithin aqueous dispersion composition containing a normal amount (effective amount) of a water-soluble physiologically active substance such as mucopolysaccharide and an aqueous cosmetic using the same. However, such compositions and cosmetics contain a physiologically active substance, so that the electric conductivity is 0.5 mS / cm or more and the transmittance at 660 nm is 90% or less. As a result, precipitation occurs during storage. It was found that there was no practical value because of the lack of stability.
[0007]
[Problems to be solved by the invention]
Under such circumstances, the present invention provides a lecithin aqueous dispersion composition having excellent stability that hardly forms precipitates or the like over a long period of time even when a normal amount of a water-soluble physiologically active substance that increases electrical conductivity is contained. An object is to provide a water-based cosmetic using the same.
[0008]
[Means for Solving the Problems]
In order to achieve the object, the present inventors, as a result of various studies, have come to the knowledge that the object can be achieved by using polyglycerin fatty acid ester among hydrophilic nonionic surfactants. It has been completed.
The present invention
(1) Hydrogenated lecithin and sodium hyaluronate 0.01-1% (in dry matter equivalent), which is a water-soluble physiologically active substance, yeast extract 0.1-5%, or seaweed extract 0.1-5% containing an electric conductivity of 0.5 mS / cm or more, and, 660 nm definitive transmittance is 90% or less, lecithin aqueous cosmetic oil component is less than 0.5 times with respect to hydrogenated lecithin An aqueous dispersion composition comprising a polyglycerin fatty acid ester having an HLB of 10 or more ,
(2) An aqueous cosmetic comprising the lecithin aqueous dispersion composition of (1) ,
It consists of
[0009]
DETAILED DESCRIPTION OF THE INVENTION
The present invention is described in detail below. In the present invention, “%” means “mass%” and “part” means “part by mass”.
In the present invention, the lecithin aqueous dispersion composition is an oily component (for example, fat-soluble vitamins, fats and oils such as animal and vegetable oils and processed oils) dispersed in water at a ratio of 0.5 times or less to hydrogenated lecithin. It is a liquid having an electric conductivity of 0.5 mS / cm or more and a transmittance at 660 nm of 90% or less.
Here, the electrical conductivity is a value obtained by measuring the lecithin aqueous dispersion composition of the present invention at 20 ° C. with a conductivity meter (“Castany LAB conductivity meter DS-14” manufactured by Horiba, Ltd.). The transmittance at 660 nm is a value measured with a spectrophotometer (wavelength 660 nm) with the lecithin dispersion composition at room temperature (20 ° C.).
[0010]
Aqueous cosmetics are cosmetics containing a lecithin water dispersion composition, and are liquid or gel-like cosmetics mainly composed of water-soluble raw materials other than creams and emulsions, such as skin lotions and cosmetics. It is a fee. The aqueous cosmetic material having an electric conductivity of 0.5 mS / cm or more is particularly suitable for the present invention because it tends to cause precipitation. In the present invention, the lecithin aqueous dispersion composition may be used as an aqueous cosmetic as it is, and 1 to 100% of the lecithin dispersion composition may be blended with respect to the entire aqueous cosmetic.
[0011]
Further, the hydrogenated lecithin used in the present invention is a phospholipid produced by subjecting purified lecithin extracted from or fractionated from a natural product such as egg yolk and soybean (substantially containing a diacyl phospholipid as a main component) to a hydrogenation treatment. The constituent fatty acids are processed so as to be saturated. Specifically, the iodine value indicating the degree of unsaturation is 30 or less (cosmetic raw material standard second edition "iodine number measurement method"), and the iodine value is 10 or less in terms of the above-mentioned oxidation stability. Is preferred. In addition, when the iodine value of hydrogenated lecithin is lowered, when it is dispersed in water having a high electric conductivity, a precipitate is likely to be formed. Therefore, those having an iodine value of 10 or less are suitable for the present invention.
The content is preferably from 0.01 to 5%, more preferably from 0.05 to 3%, based on the entire lecithin water dispersion composition, from the viewpoint of the feeling of use and moisture retention when it is contained in a cosmetic.
The hydrogenated lecithin used in the lecithin aqueous dispersion composition of the present invention is preferably egg yolk-derived hydrogenated lecithin from the viewpoint of stability.
Here, hydrogenated lecithin is used because cosmetics are usually used at room temperature for a long period of time, so that it is difficult to cause off-flavors and browning due to oxidation.
[0012]
In addition, the polyglycerol fatty acid ester used in the present invention is obtained by esterifying a fatty acid to polyglycerol obtained by polymerizing glycerol. As what is marketed, there are various kinds of glycerin having an average degree of polymerization of 2 to 10, and there are many kinds depending on the degree of polymerization of glycerin, the type of fatty acid, and the degree of esterification.
The polyglycerin fatty acid ester used in the present invention may be any commercially available one, but those having an HLB (hydrophilic / lipophilic balance) of 10 or more are preferable from the viewpoint of the effect of the present invention.
The amount of this substance to be added to the lecithin aqueous dispersion composition of the present invention is preferably 0.05 to 3 times, more preferably 0.1 to 3 times the amount of hydrogenated lecithin used in the present invention in terms of the effects of the present invention. 1.5 times the amount.
[0013]
Further, in the present invention, when the lecithin aqueous dispersion composition or aqueous cosmetic contains a usual amount of use, the substance for increasing the electrical conductivity includes a water-soluble physiologically active substance, such as hyaluronic acid, chondroitin sulfate. , Pyrrolidone carboxylic acid and salts thereof, collagen, yeast extract, seaweed extract, various amino acids and peptides and mixtures thereof, α-hydroxy acid, ascorbic acid phosphate, ascorbic acid sulfate, pyridoxine hydrochloride, pantothenic acid and salts thereof Water-soluble vitamins such as those that require neutralization because the aqueous solution exhibits acidity or alkalinity, for example, substances such as ascorbic acid 2-glucoside and carboxyvinyl polymer.
Here, the normal usage amount varies depending on the substance to be contained, but for example, in the case of sodium hyaluronate, 0.01 to 1% (in terms of dry matter) with respect to the whole, 0.1 to 5% in the case of yeast extract In the case of seaweed extract, it is about 0.1 to 5%.
[0014]
The method for producing the lecithin aqueous dispersion composition of the present invention may be produced in accordance with a conventional liposome preparation method on an industrial scale. For example, each component is dispersed in water such as purified water, and further heated as necessary. The method of processing with a homogenizer is mentioned. Moreover, what is necessary is just to mix the aqueous solution containing the lecithin water dispersion composition and the aqueous solution containing another aqueous raw material, for example in the manufacturing method of the aqueous cosmetics using the lecithin water dispersion composition of this invention.
[0015]
The lecithin water-dispersed composition and the aqueous cosmetic of the present invention can contain other cosmetic raw materials as long as the effects of the present invention are not impaired. For example, polyhydric alcohols such as 1,3-butylene glycol, propylene glycol, glycerin, isoprene glycol and pentylene glycol, lower alcohols such as ethanol and isopropanol, preservatives such as paraben and phenoxyethanol, emulsifiers, fragrances, dyes, etc. It is done.
[0016]
The lecithin aqueous dispersion composition of the present invention and the aqueous cosmetic using the same contain a polyglycerin fatty acid ester as a hydrophilic nonionic surfactant. Even when the electric conductivity is 0.5 mS / cm or more and the transmittance at 660 nm is 90% or less using the amount used, as shown in the examples below, no separation or precipitation occurs during storage. It is stable.
[0017]
【Example】
[Example 1], [Comparative Example 1] and [Comparative Example 2]
The lecithin water-dispersed compositions of Comparative Example 1, Comparative Example 2, and Example 1 were made as trials with the raw materials and blending ratios shown in Table 1, respectively.
Specifically, first, each of the raw materials for phase A and the raw materials for phase B are separately mixed, heated to 70 ° C. and uniformly, and then the solution of phase B is added to the solution of phase A. Finally, the mixture was coarsely dispersed, and finally treated with a pressure of 30,000 psi using a high-pressure emulsifier to obtain a lecithin aqueous dispersion composition.
[0018]
In addition, all the obtained lecithin aqueous dispersion compositions were liquid in nature, had an electric conductivity of 0.5 mS / cm or more and a transmittance of 660 nm of 90% or less.
The hydrogenated purified egg yolk lecithin used as a raw material had an iodine value of 10 or less, and polyglycerin fatty acid ester and polyoxyethylene hydrogenated castor oil used HLB of 10 or more.
Each of the lecithin aqueous dispersion compositions was filled and sealed in glass bottles to prepare 3 bottles of the same sample, which were stored at 4 ° C., 40 ° C., and room temperature (20 ° C.) for 60 days, respectively. When observed, the result of Table 1 was obtained.
[0019]
[Table 1]
From Table 1, it can be understood that when a polyglycerin fatty acid ester is used as a hydrophilic nonionic surfactant, a stable lecithin aqueous dispersion composition that does not cause separation or precipitation during storage can be obtained.
[0021]
[Example 2]
A lecithin water-dispersed composition was made as an experiment in the same manner as in Example 1 with the raw materials and blending ratio shown in Table 2.
In addition, the obtained lecithin aqueous dispersion composition was gel-like, had an electric conductivity of 0.5 mS / cm or more and a transmittance of 660 nm of 90% or less.
The hydrogenated purified egg yolk lecithin used as a raw material had an iodine value of 10 or less, and the polyglycerin fatty acid ester used was an HLB of 10 or more.
When the same storage test as in Example 1 was performed on the lecithin aqueous dispersion composition, the results shown in Table 2 were obtained.
[0022]
[Table 2]
From Table 2, even if it uses a yeast extract instead of the seaweed extract of Example 1 as a water-soluble physiologically active substance, a stable lecithin aqueous dispersion composition that does not cause separation or precipitation during storage can be obtained. Can understand.
A lecithin aqueous dispersion composition was prototyped using sodium hyaluronate (blending amount 0.2%) instead of the yeast extract, and the same results as above were obtained.
[0024]
[Example 3]
The following raw materials were prepared.
Next, after raw materials other than the water dispersion composition of Example 1 were dissolved in purified water, this was mixed with the lecithin water dispersion composition of Example 1 to produce a liquid lotion.
The obtained lotion was excellent in feeling of use and moisture retention, and was stable with no precipitation or the like over a long period of time.
In addition, the obtained lotion had an electric conductivity of 0.5 mS / cm or more and a transmittance of 660 nm of 90% or less.
[0026]
[Example 4]
The following raw materials were prepared.
Next, after dispersing the carboxyvinyl polymer in purified water in which methylparaben is dissolved, the pH is adjusted to 7.0 with potassium hydroxide, and after the raw materials other than the lecithin aqueous dispersion composition of Example 2 are dissolved in this solution, This was mixed with the aqueous dispersion composition of Example 2 to produce a gel-like serum.
The obtained cosmetic liquid was excellent in feeling of use and moisture retention, and was stable without causing precipitation or the like over a long period of time.
The obtained cosmetic liquid had an electric conductivity of 0.5 mS / cm or more and a transmittance of 660 nm of 90% or less.
In addition, the same gel-like cosmetic liquid as described above was prototyped using a lecithin aqueous dispersion composition using sodium hyaluronate as a raw material, and the same result as above was obtained.
【The invention's effect】
As described above, the lecithin aqueous dispersion composition of the present invention and the aqueous cosmetic composition using the same are precipitated over a long period of time even when a normal amount of a water-soluble physiologically active substance that increases electrical conductivity is contained. Does not occur and is stable. Therefore, according to this invention, the new type cosmetics excellent in a usability | use_condition and moisture retention can be provided.
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| JP4297648B2 true JP4297648B2 (en) | 2009-07-15 |
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