JP4294247B2 - 速度調節可能な薬剤伝達システム - Google Patents
速度調節可能な薬剤伝達システム Download PDFInfo
- Publication number
- JP4294247B2 JP4294247B2 JP2001549729A JP2001549729A JP4294247B2 JP 4294247 B2 JP4294247 B2 JP 4294247B2 JP 2001549729 A JP2001549729 A JP 2001549729A JP 2001549729 A JP2001549729 A JP 2001549729A JP 4294247 B2 JP4294247 B2 JP 4294247B2
- Authority
- JP
- Japan
- Prior art keywords
- drug delivery
- delivery system
- galvanic
- therapeutic drug
- power source
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000012377 drug delivery Methods 0.000 title claims description 35
- 239000003814 drug Substances 0.000 claims abstract description 47
- 229940124597 therapeutic agent Drugs 0.000 claims abstract description 7
- 229940079593 drug Drugs 0.000 claims description 40
- 229940126585 therapeutic drug Drugs 0.000 claims description 24
- 229910021607 Silver chloride Inorganic materials 0.000 claims description 12
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 claims description 12
- 230000005540 biological transmission Effects 0.000 claims description 10
- 229910052725 zinc Inorganic materials 0.000 claims description 8
- 238000012546 transfer Methods 0.000 claims description 5
- 229910052749 magnesium Inorganic materials 0.000 claims description 2
- 239000013543 active substance Substances 0.000 claims 4
- 239000000463 material Substances 0.000 description 33
- 241000894007 species Species 0.000 description 29
- 239000010410 layer Substances 0.000 description 14
- 125000000129 anionic group Chemical group 0.000 description 10
- 125000002091 cationic group Chemical group 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 239000011701 zinc Substances 0.000 description 9
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 6
- 239000004020 conductor Substances 0.000 description 6
- 238000010586 diagram Methods 0.000 description 6
- 150000002500 ions Chemical class 0.000 description 6
- 239000006187 pill Substances 0.000 description 6
- 230000000670 limiting effect Effects 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 239000000758 substrate Substances 0.000 description 5
- 230000008901 benefit Effects 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 239000012790 adhesive layer Substances 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 238000005868 electrolysis reaction Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000004698 Polyethylene Substances 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000000875 corresponding effect Effects 0.000 description 2
- 239000003792 electrolyte Substances 0.000 description 2
- NUJOXMJBOLGQSY-UHFFFAOYSA-N manganese dioxide Chemical compound O=[Mn]=O NUJOXMJBOLGQSY-UHFFFAOYSA-N 0.000 description 2
- 230000001590 oxidative effect Effects 0.000 description 2
- -1 polyethylene Polymers 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000007650 screen-printing Methods 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 230000037317 transdermal delivery Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- QCHFTSOMWOSFHM-WPRPVWTQSA-N (+)-Pilocarpine Chemical compound C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C QCHFTSOMWOSFHM-WPRPVWTQSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- QCHFTSOMWOSFHM-UHFFFAOYSA-N SJ000285536 Natural products C1OC(=O)C(CC)C1CC1=CN=CN1C QCHFTSOMWOSFHM-UHFFFAOYSA-N 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- JIAARYAFYJHUJI-UHFFFAOYSA-L Zinc chloride Inorganic materials [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 239000010405 anode material Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000010406 cathode material Substances 0.000 description 1
- 150000001793 charged compounds Chemical class 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 1
- 229960003957 dexamethasone Drugs 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000011263 electroactive material Substances 0.000 description 1
- 238000009713 electroplating Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 229960004194 lidocaine Drugs 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229960001416 pilocarpine Drugs 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 230000001839 systemic circulation Effects 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 229910021655 trace metal ion Inorganic materials 0.000 description 1
- 238000013271 transdermal drug delivery Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0448—Drug reservoir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
- A61N1/0436—Material of the electrode
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
- A61N1/0432—Anode and cathode
- A61N1/044—Shape of the electrode
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Electrotherapy Devices (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17371099P | 1999-12-30 | 1999-12-30 | |
| US60/173,710 | 1999-12-30 | ||
| US09/613,984 | 2000-07-11 | ||
| US09/613,984 US6421561B1 (en) | 1999-12-30 | 2000-07-11 | Rate adjustable drug delivery system |
| PCT/US2000/027301 WO2001049365A1 (en) | 1999-12-30 | 2000-10-04 | Rate adjustable drug delivery system |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006228645A Division JP2007014793A (ja) | 1999-12-30 | 2006-08-25 | 速度調節可能な薬剤伝達システム |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003530909A JP2003530909A (ja) | 2003-10-21 |
| JP4294247B2 true JP4294247B2 (ja) | 2009-07-08 |
Family
ID=26869460
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001549729A Expired - Fee Related JP4294247B2 (ja) | 1999-12-30 | 2000-10-04 | 速度調節可能な薬剤伝達システム |
| JP2006228645A Abandoned JP2007014793A (ja) | 1999-12-30 | 2006-08-25 | 速度調節可能な薬剤伝達システム |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006228645A Abandoned JP2007014793A (ja) | 1999-12-30 | 2006-08-25 | 速度調節可能な薬剤伝達システム |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6421561B1 (enExample) |
| EP (1) | EP1242142B1 (enExample) |
| JP (2) | JP4294247B2 (enExample) |
| AT (1) | ATE372146T1 (enExample) |
| AU (1) | AU1191301A (enExample) |
| DE (1) | DE60036306T2 (enExample) |
| WO (1) | WO2001049365A1 (enExample) |
Families Citing this family (103)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4421113B2 (ja) | 1998-08-31 | 2010-02-24 | トラヴァンティ ファーマ インコーポレイテッド | 制御投与薬物送達システム |
| US6421561B1 (en) | 1999-12-30 | 2002-07-16 | Birch Point Medical, Inc. | Rate adjustable drug delivery system |
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| US20030035984A1 (en) * | 2001-08-15 | 2003-02-20 | Colborn Jeffrey A. | Metal fuel cell system for providing backup power to one or more loads |
| CN1607970B (zh) * | 2001-10-24 | 2010-11-10 | 纸型电池有限公司 | 皮肤贴片 |
| US7349733B2 (en) * | 2001-11-02 | 2008-03-25 | Ceramatel, Inc. | Iontophoretic drug delivery systems |
| US6775570B2 (en) * | 2002-02-04 | 2004-08-10 | Ceramatec, Inc. | Iontophoretic treatment device |
| US7047069B2 (en) * | 2002-02-04 | 2006-05-16 | Ceramatec, Inc. | Iontophoretic fluid delivery device |
| US20040009398A1 (en) | 2002-06-19 | 2004-01-15 | Dorfman Jay Robert | Zinc polymer thick film composition |
| US20060009730A2 (en) * | 2002-07-29 | 2006-01-12 | Eemso, Inc. | Iontophoretic Transdermal Delivery of One or More Therapeutic Agents |
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| US6745071B1 (en) | 2003-02-21 | 2004-06-01 | Birch Point Medical, Inc. | Iontophoretic drug delivery system |
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| US8734421B2 (en) | 2003-06-30 | 2014-05-27 | Johnson & Johnson Consumer Companies, Inc. | Methods of treating pores on the skin with electricity |
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-
2000
- 2000-07-11 US US09/613,984 patent/US6421561B1/en not_active Expired - Lifetime
- 2000-10-04 DE DE60036306T patent/DE60036306T2/de not_active Expired - Lifetime
- 2000-10-04 EP EP00973406A patent/EP1242142B1/en not_active Expired - Lifetime
- 2000-10-04 WO PCT/US2000/027301 patent/WO2001049365A1/en not_active Ceased
- 2000-10-04 AU AU11913/01A patent/AU1191301A/en not_active Abandoned
- 2000-10-04 JP JP2001549729A patent/JP4294247B2/ja not_active Expired - Fee Related
- 2000-10-04 AT AT00973406T patent/ATE372146T1/de not_active IP Right Cessation
-
2002
- 2002-06-03 US US10/162,473 patent/US7016723B2/en not_active Expired - Lifetime
-
2006
- 2006-08-25 JP JP2006228645A patent/JP2007014793A/ja not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1242142B1 (en) | 2007-09-05 |
| DE60036306T2 (de) | 2008-06-05 |
| JP2007014793A (ja) | 2007-01-25 |
| WO2001049365A1 (en) | 2001-07-12 |
| JP2003530909A (ja) | 2003-10-21 |
| EP1242142A1 (en) | 2002-09-25 |
| US20020188241A1 (en) | 2002-12-12 |
| US6421561B1 (en) | 2002-07-16 |
| ATE372146T1 (de) | 2007-09-15 |
| AU1191301A (en) | 2001-07-16 |
| DE60036306D1 (de) | 2007-10-18 |
| US7016723B2 (en) | 2006-03-21 |
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