JP4223681B2 - 病原性タンパク質沈着の基礎構造の会合の測定方法 - Google Patents

病原性タンパク質沈着の基礎構造の会合の測定方法 Download PDF

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JP4223681B2
JP4223681B2 JP2000513150A JP2000513150A JP4223681B2 JP 4223681 B2 JP4223681 B2 JP 4223681B2 JP 2000513150 A JP2000513150 A JP 2000513150A JP 2000513150 A JP2000513150 A JP 2000513150A JP 4223681 B2 JP4223681 B2 JP 4223681B2
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probe
pathogenic protein
pathogenic
protein
association
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JP2001517800A5 (https=
JP2001517800A (ja
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デトレフ リースナー
カリン ポスト
オリバー シェーファー
マルティン ピシュケ
マンフレッド アイゲン
ヤン ビーシュケ
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Evotec OAI AG
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Evotec OAI AG
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Priority claimed from DE1997152712 external-priority patent/DE19752712C2/de
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
JP2000513150A 1997-09-19 1998-09-18 病原性タンパク質沈着の基礎構造の会合の測定方法 Expired - Lifetime JP4223681B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
DE19741486 1997-09-19
DE1997152712 DE19752712C2 (de) 1997-11-28 1997-11-28 Verfahren zur Messung der Assoziation von Teilstrukturen pathologischer Proteinablagerungen
DE19818917.6 1998-04-28
DE19818917 1998-04-28
DE19752712.4 1998-04-28
DE19741486.9 1998-04-28
PCT/EP1998/005958 WO1999015903A1 (de) 1997-09-19 1998-09-18 Verfahren zur messung der assoziation von teilstrukturen pathologischer proteinablagerungen

Publications (3)

Publication Number Publication Date
JP2001517800A JP2001517800A (ja) 2001-10-09
JP2001517800A5 JP2001517800A5 (https=) 2006-12-07
JP4223681B2 true JP4223681B2 (ja) 2009-02-12

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JP2000513150A Expired - Lifetime JP4223681B2 (ja) 1997-09-19 1998-09-18 病原性タンパク質沈着の基礎構造の会合の測定方法

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US (1) US6498017B2 (https=)
EP (1) EP1015888B1 (https=)
JP (1) JP4223681B2 (https=)
AT (1) ATE223058T1 (https=)
AU (1) AU9541398A (https=)
DE (1) DE59805338D1 (https=)
WO (1) WO1999015903A1 (https=)

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DE19952955A1 (de) * 1999-11-03 2001-05-17 Acgt Progenomics Ag Verfahren zur Charakterisierung und zur Auftrennung von molekularen Assoziaten
DE10013854A1 (de) * 2000-03-17 2001-09-20 Zeiss Carl Jena Gmbh Anordnung und Verfahren zur Untersuchung von Wirkstoffen zur Beeinflussung intrazellulärer Vorgänge
US7146209B2 (en) * 2000-05-08 2006-12-05 Brainsgate, Ltd. Stimulation for treating eye pathologies
US7640062B2 (en) 2000-05-08 2009-12-29 Brainsgate Ltd. Methods and systems for management of alzheimer's disease
US6603546B1 (en) * 2000-07-21 2003-08-05 I.S.S. (Usa) Inc. Rapid high throughput spectrometer and method
US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
EP1395833B1 (en) * 2001-05-31 2013-02-27 Adlyfe, Inc. Misfolded protein sensor method
EP1321771A1 (de) * 2001-12-21 2003-06-25 Evotec Analytical Systems GmbH Verfahren zur qualitativen und/oder quantitativen Bestimmung von Aggregaten
US7939641B2 (en) * 2002-04-09 2011-05-10 The Scripps Research Institute Motif-grafted hybrid polypeptides and uses thereof
US7684859B2 (en) * 2002-04-25 2010-03-23 Brainsgate Ltd. Stimulation of the OTIC ganglion for treating medical conditions
WO2004043218A2 (en) * 2002-11-14 2004-05-27 Brainsgate Ltd. Surgical tools and techniques for stimulation
AU2003223087A1 (en) * 2002-04-25 2003-11-10 Brainsgate Ltd. Methods and apparatus for modifying properties of the bbb and cerebral circulation by using the neuroexcitatory and/or neuroinhibitory effects of odorants on nerves in the head
US7456954B2 (en) * 2003-06-20 2008-11-25 The Regents Of The University Of California Modulated excitation fluorescence analysis
US20060035242A1 (en) * 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
EP1600774A1 (de) * 2004-03-12 2005-11-30 Ludwig-Maximilians-Universität München Verfahren zur Identifizierung von Substanzen zur Beeinflussung der Aggregationen von Proteinen
US8010189B2 (en) * 2004-02-20 2011-08-30 Brainsgate Ltd. SPG stimulation for treating complications of subarachnoid hemorrhage
US8055347B2 (en) 2005-08-19 2011-11-08 Brainsgate Ltd. Stimulation for treating brain events and other conditions
US9233245B2 (en) 2004-02-20 2016-01-12 Brainsgate Ltd. SPG stimulation
JP4338590B2 (ja) * 2004-06-03 2009-10-07 独立行政法人科学技術振興機構 蛍光相関分光法による抗原の迅速検出及び/又は測定法。
US20090299418A1 (en) * 2004-08-23 2009-12-03 Brainsgate Ltd. Concurrent bilateral spg modulation
US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
WO2006076683A2 (en) * 2005-01-13 2006-07-20 Novartis Vaccines And Diagnostics Inc. Isolation and detection of pathogenic prions
US20090130774A1 (en) * 2005-01-13 2009-05-21 David Peretz Elisa assays using prion-specific peptide reagents
US8372593B2 (en) * 2005-02-15 2013-02-12 Adlyfe, Inc. Method for detecting misfolded proteins and prions
US20090253217A1 (en) 2005-09-12 2009-10-08 Japan Science And Technology Agency Method of Quickly Detecting Antigen Using Fluorescence Correlation Spectroscopy or Fluorescence Cross-Correlation Spectroscopy
JP5097206B2 (ja) * 2006-07-28 2012-12-12 エイディーライフ インコーポレイティッド 診断および治療のためのペプチドプローブ
EP1882944B1 (en) * 2006-07-28 2009-03-18 VISTA VENTURES GmbH Method for the detection of amyloid-beta oligomers in body fluids
WO2008022035A2 (en) * 2006-08-10 2008-02-21 The Scripps Research Institute Methods for identifying cellular modulators of disaggregation activity or aggregation activity in an animal
US20090210026A1 (en) * 2006-08-17 2009-08-20 Brainsgate Ltd. Spg stimulation for enhancing neurogenesis and brain metabolism
JP2010043865A (ja) * 2006-12-12 2010-02-25 Olympus Corp 異常型プリオンの検出方法
US7860569B2 (en) 2007-10-18 2010-12-28 Brainsgate, Ltd. Long-term SPG stimulation therapy for prevention of vascular dementia
EP2282753A1 (en) * 2008-04-30 2011-02-16 Novartis AG Assay for pathogenic conformers
EP2344913B1 (en) * 2008-10-02 2015-02-18 Ramot at Tel-Aviv University Ltd. Method and system for emitting light
US20100227794A1 (en) * 2008-11-26 2010-09-09 I.S.T. Corporation Smart contrast agent and method for detecting transition metal ions and treating related disorders
US20100129290A1 (en) * 2008-11-26 2010-05-27 I.S.T. Corporation Smart contrast agent and detection method for detecting transition metal ions
US10974078B2 (en) 2012-12-27 2021-04-13 Brainsonix Corporation Treating degenerative dementia with low intensity focused ultrasound pulsation (LIFUP) device
US9061133B2 (en) 2012-12-27 2015-06-23 Brainsonix Corporation Focused ultrasonic transducer navigation system
US10512794B2 (en) 2016-12-16 2019-12-24 Brainsonix Corporation Stereotactic frame
EP2878335B1 (en) 2013-11-10 2018-01-03 Brainsgate Ltd. Implant and delivery system for neural stimulator
US10271907B2 (en) 2015-05-13 2019-04-30 Brainsgate Ltd. Implant and delivery system for neural stimulator
ES2896128T3 (es) * 2016-12-15 2022-02-24 Brainsonix Corp Tratamiento de la demencia degenerativa utilizando un dispositivo de pulsaciones de ultrasonidos enfocados de baja intensidad (LIFUP)
GB201805466D0 (en) * 2018-04-03 2018-05-16 Vukojevic Vladana Methods
US11759661B2 (en) 2020-05-20 2023-09-19 Brainsonix Corporation Ultrasonic transducer treatment device
US12257446B2 (en) 2020-08-24 2025-03-25 Brainsonix Corporation Systems and methods for neuromodulation of neuronal circuits using transcranial focused microwave pulses

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JPH05506990A (ja) * 1990-04-24 1993-10-14 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア プロテアーゼ ネキシン―2の精製、検出、及び使用方法
WO1993023432A1 (en) 1992-05-15 1993-11-25 New York University Soluble prion polypeptides, and methods for detecting and purifying thereof
BR9610580A (pt) 1995-09-14 2000-10-24 Univ California Anticorpos especìficos para prpse nativos
ES2171231T3 (es) 1995-10-26 2002-09-01 Winnacker Ernst Ludwig Prof Moleculas de acido nucleico capaces de distinguir prpc y prpsc de las proteinas prionicas y los procesos para su produccion.

Also Published As

Publication number Publication date
US20020042121A1 (en) 2002-04-11
EP1015888B1 (de) 2002-08-28
US6498017B2 (en) 2002-12-24
AU9541398A (en) 1999-04-12
DE59805338D1 (de) 2002-10-02
ATE223058T1 (de) 2002-09-15
EP1015888A1 (de) 2000-07-05
WO1999015903A1 (de) 1999-04-01
JP2001517800A (ja) 2001-10-09

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