DE59805338D1 - Verfahren zur messung der assoziation von teilstrukturen pathologischer proteinablagerungen - Google Patents

Verfahren zur messung der assoziation von teilstrukturen pathologischer proteinablagerungen

Info

Publication number
DE59805338D1
DE59805338D1 DE59805338T DE59805338T DE59805338D1 DE 59805338 D1 DE59805338 D1 DE 59805338D1 DE 59805338 T DE59805338 T DE 59805338T DE 59805338 T DE59805338 T DE 59805338T DE 59805338 D1 DE59805338 D1 DE 59805338D1
Authority
DE
Germany
Prior art keywords
pathological protein
depositions
substructures
protein depositions
association
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE59805338T
Other languages
German (de)
English (en)
Inventor
Detlev Riesner
Karin Post
Oliver Schaefer
Martin Pitschke
Manfred Eigen
Jan Bieschke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evotec OAI AG
Original Assignee
Evotec OAI AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE1997152712 external-priority patent/DE19752712C2/de
Application filed by Evotec OAI AG filed Critical Evotec OAI AG
Application granted granted Critical
Publication of DE59805338D1 publication Critical patent/DE59805338D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
DE59805338T 1997-09-19 1998-09-18 Verfahren zur messung der assoziation von teilstrukturen pathologischer proteinablagerungen Expired - Lifetime DE59805338D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19741486 1997-09-19
DE1997152712 DE19752712C2 (de) 1997-11-28 1997-11-28 Verfahren zur Messung der Assoziation von Teilstrukturen pathologischer Proteinablagerungen
DE19818917 1998-04-28
PCT/EP1998/005958 WO1999015903A1 (de) 1997-09-19 1998-09-18 Verfahren zur messung der assoziation von teilstrukturen pathologischer proteinablagerungen

Publications (1)

Publication Number Publication Date
DE59805338D1 true DE59805338D1 (de) 2002-10-02

Family

ID=27217757

Family Applications (1)

Application Number Title Priority Date Filing Date
DE59805338T Expired - Lifetime DE59805338D1 (de) 1997-09-19 1998-09-18 Verfahren zur messung der assoziation von teilstrukturen pathologischer proteinablagerungen

Country Status (7)

Country Link
US (1) US6498017B2 (https=)
EP (1) EP1015888B1 (https=)
JP (1) JP4223681B2 (https=)
AT (1) ATE223058T1 (https=)
AU (1) AU9541398A (https=)
DE (1) DE59805338D1 (https=)
WO (1) WO1999015903A1 (https=)

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EP1216417A1 (de) * 1999-09-28 2002-06-26 Evotec OAI AG Quantitative analyse und typisierung subzellulärer partikel
DE19952955A1 (de) * 1999-11-03 2001-05-17 Acgt Progenomics Ag Verfahren zur Charakterisierung und zur Auftrennung von molekularen Assoziaten
DE10013854A1 (de) * 2000-03-17 2001-09-20 Zeiss Carl Jena Gmbh Anordnung und Verfahren zur Untersuchung von Wirkstoffen zur Beeinflussung intrazellulärer Vorgänge
US7146209B2 (en) * 2000-05-08 2006-12-05 Brainsgate, Ltd. Stimulation for treating eye pathologies
US7640062B2 (en) 2000-05-08 2009-12-29 Brainsgate Ltd. Methods and systems for management of alzheimer's disease
US6603546B1 (en) * 2000-07-21 2003-08-05 I.S.S. (Usa) Inc. Rapid high throughput spectrometer and method
US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
EP1395833B1 (en) * 2001-05-31 2013-02-27 Adlyfe, Inc. Misfolded protein sensor method
EP1321771A1 (de) * 2001-12-21 2003-06-25 Evotec Analytical Systems GmbH Verfahren zur qualitativen und/oder quantitativen Bestimmung von Aggregaten
US7939641B2 (en) * 2002-04-09 2011-05-10 The Scripps Research Institute Motif-grafted hybrid polypeptides and uses thereof
US7684859B2 (en) * 2002-04-25 2010-03-23 Brainsgate Ltd. Stimulation of the OTIC ganglion for treating medical conditions
WO2004043218A2 (en) * 2002-11-14 2004-05-27 Brainsgate Ltd. Surgical tools and techniques for stimulation
AU2003223087A1 (en) * 2002-04-25 2003-11-10 Brainsgate Ltd. Methods and apparatus for modifying properties of the bbb and cerebral circulation by using the neuroexcitatory and/or neuroinhibitory effects of odorants on nerves in the head
US7456954B2 (en) * 2003-06-20 2008-11-25 The Regents Of The University Of California Modulated excitation fluorescence analysis
US20060035242A1 (en) * 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
EP1600774A1 (de) * 2004-03-12 2005-11-30 Ludwig-Maximilians-Universität München Verfahren zur Identifizierung von Substanzen zur Beeinflussung der Aggregationen von Proteinen
US8010189B2 (en) * 2004-02-20 2011-08-30 Brainsgate Ltd. SPG stimulation for treating complications of subarachnoid hemorrhage
US8055347B2 (en) 2005-08-19 2011-11-08 Brainsgate Ltd. Stimulation for treating brain events and other conditions
US9233245B2 (en) 2004-02-20 2016-01-12 Brainsgate Ltd. SPG stimulation
JP4338590B2 (ja) * 2004-06-03 2009-10-07 独立行政法人科学技術振興機構 蛍光相関分光法による抗原の迅速検出及び／又は測定法。
US20090299418A1 (en) * 2004-08-23 2009-12-03 Brainsgate Ltd. Concurrent bilateral spg modulation
US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
WO2006076683A2 (en) * 2005-01-13 2006-07-20 Novartis Vaccines And Diagnostics Inc. Isolation and detection of pathogenic prions
US20090130774A1 (en) * 2005-01-13 2009-05-21 David Peretz Elisa assays using prion-specific peptide reagents
US8372593B2 (en) * 2005-02-15 2013-02-12 Adlyfe, Inc. Method for detecting misfolded proteins and prions
US20090253217A1 (en) 2005-09-12 2009-10-08 Japan Science And Technology Agency Method of Quickly Detecting Antigen Using Fluorescence Correlation Spectroscopy or Fluorescence Cross-Correlation Spectroscopy
JP5097206B2 (ja) * 2006-07-28 2012-12-12 エイディーライフ インコーポレイティッド 診断および治療のためのペプチドプローブ
EP1882944B1 (en) * 2006-07-28 2009-03-18 VISTA VENTURES GmbH Method for the detection of amyloid-beta oligomers in body fluids
WO2008022035A2 (en) * 2006-08-10 2008-02-21 The Scripps Research Institute Methods for identifying cellular modulators of disaggregation activity or aggregation activity in an animal
US20090210026A1 (en) * 2006-08-17 2009-08-20 Brainsgate Ltd. Spg stimulation for enhancing neurogenesis and brain metabolism
JP2010043865A (ja) * 2006-12-12 2010-02-25 Olympus Corp 異常型プリオンの検出方法
US7860569B2 (en) 2007-10-18 2010-12-28 Brainsgate, Ltd. Long-term SPG stimulation therapy for prevention of vascular dementia
EP2282753A1 (en) * 2008-04-30 2011-02-16 Novartis AG Assay for pathogenic conformers
EP2344913B1 (en) * 2008-10-02 2015-02-18 Ramot at Tel-Aviv University Ltd. Method and system for emitting light
US20100227794A1 (en) * 2008-11-26 2010-09-09 I.S.T. Corporation Smart contrast agent and method for detecting transition metal ions and treating related disorders
US20100129290A1 (en) * 2008-11-26 2010-05-27 I.S.T. Corporation Smart contrast agent and detection method for detecting transition metal ions
US10974078B2 (en) 2012-12-27 2021-04-13 Brainsonix Corporation Treating degenerative dementia with low intensity focused ultrasound pulsation (LIFUP) device
US9061133B2 (en) 2012-12-27 2015-06-23 Brainsonix Corporation Focused ultrasonic transducer navigation system
US10512794B2 (en) 2016-12-16 2019-12-24 Brainsonix Corporation Stereotactic frame
EP2878335B1 (en) 2013-11-10 2018-01-03 Brainsgate Ltd. Implant and delivery system for neural stimulator
US10271907B2 (en) 2015-05-13 2019-04-30 Brainsgate Ltd. Implant and delivery system for neural stimulator
ES2896128T3 (es) * 2016-12-15 2022-02-24 Brainsonix Corp Tratamiento de la demencia degenerativa utilizando un dispositivo de pulsaciones de ultrasonidos enfocados de baja intensidad (LIFUP)
GB201805466D0 (en) * 2018-04-03 2018-05-16 Vukojevic Vladana Methods
US11759661B2 (en) 2020-05-20 2023-09-19 Brainsonix Corporation Ultrasonic transducer treatment device
US12257446B2 (en) 2020-08-24 2025-03-25 Brainsonix Corporation Systems and methods for neuromodulation of neuronal circuits using transcranial focused microwave pulses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05506990A (ja) * 1990-04-24 1993-10-14 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア プロテアーゼ　ネキシン―２の精製、検出、及び使用方法
WO1993023432A1 (en) 1992-05-15 1993-11-25 New York University Soluble prion polypeptides, and methods for detecting and purifying thereof
BR9610580A (pt) 1995-09-14 2000-10-24 Univ California Anticorpos especìficos para prpse nativos
ES2171231T3 (es) 1995-10-26 2002-09-01 Winnacker Ernst Ludwig Prof Moleculas de acido nucleico capaces de distinguir prpc y prpsc de las proteinas prionicas y los procesos para su produccion.

Also Published As

Publication number Publication date
US20020042121A1 (en) 2002-04-11
JP4223681B2 (ja) 2009-02-12
EP1015888B1 (de) 2002-08-28
US6498017B2 (en) 2002-12-24
AU9541398A (en) 1999-04-12
ATE223058T1 (de) 2002-09-15
EP1015888A1 (de) 2000-07-05
WO1999015903A1 (de) 1999-04-01
JP2001517800A (ja) 2001-10-09

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