JP4183754B2 - Ｈｉｖ―１感染を阻害するためのケモカイン受容体の使用 - Google Patents
Ｈｉｖ―１感染を阻害するためのケモカイン受容体の使用 Download PDFInfo
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- JP4183754B2 JP4183754B2 JP50189598A JP50189598A JP4183754B2 JP 4183754 B2 JP4183754 B2 JP 4183754B2 JP 50189598 A JP50189598 A JP 50189598A JP 50189598 A JP50189598 A JP 50189598A JP 4183754 B2 JP4183754 B2 JP 4183754B2
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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| US1994196P | 1996-06-14 | 1996-06-14 | |
| US66509096A | 1996-06-14 | 1996-06-14 | |
| US60/019,941 | 1996-06-14 | ||
| US08/665,090 | 1996-06-14 | ||
| PCT/US1997/010619 WO1997047319A1 (en) | 1996-06-14 | 1997-06-13 | Uses of a chemokine receptor for inhibiting hiv-1 infection |
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| JP2001503608A JP2001503608A (ja) | 2001-03-21 |
| JP4183754B2 true JP4183754B2 (ja) | 2008-11-19 |
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| EP (1) | EP0956044A4 (de) |
| JP (1) | JP4183754B2 (de) |
| AU (2) | AU3390297A (de) |
| CA (1) | CA2257991A1 (de) |
| WO (2) | WO1997047319A1 (de) |
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| US8168663B2 (en) | 2002-12-19 | 2012-05-01 | The Scripps Research Institute | Pharmaceutically acceptable salt of 6-carboxy-2-(3,5 dichlorophenyl)-benzoxazole, and a pharmaceutical composition comprising the salt thereof |
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| US6025154A (en) | 1995-06-06 | 2000-02-15 | Human Genome Sciences, Inc. | Polynucleotides encoding human G-protein chemokine receptor HDGNR10 |
| US6743594B1 (en) | 1995-06-06 | 2004-06-01 | Human Genome Sciences, Inc. | Methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5) |
| US6261763B1 (en) | 1995-06-07 | 2001-07-17 | Progenics Pharmaceuticals, Inc. | Fluorescence resonance energy transfer screening assay for the identification of compounds that are capable of abrogating macrophage-tropic HIV-1 cell fusion |
| US6265184B1 (en) | 1995-12-20 | 2001-07-24 | Icos Corporation | Polynucleotides encoding chemokine receptor 88C |
| US7118859B2 (en) | 1996-01-17 | 2006-10-10 | Progenics Pharmaceuticals, Inc. | Methods for inhibiting HIV-1 infection |
| US7858298B1 (en) | 1996-04-01 | 2010-12-28 | Progenics Pharmaceuticals Inc. | Methods of inhibiting human immunodeficiency virus type 1 (HIV-1) infection through the administration of CCR5 chemokine receptor antagonists |
| US6107019A (en) * | 1996-06-14 | 2000-08-22 | Progenics Pharmaceuticals, Inc. | Method for preventing HIV-1 infection of CD4+ cells |
| EP0975749A2 (de) | 1996-05-28 | 2000-02-02 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Cc chemokine receptor 5, antikörper dazu, transgene tieren |
| US6528625B1 (en) | 1996-10-28 | 2003-03-04 | Millennium Pharmaceuticals, Inc. | Anti-CCR5 antibodies and kits comprising same |
| US6153431A (en) * | 1997-05-30 | 2000-11-28 | Fond Mondiale Rech & Prev Sida | Human immunodeficiency virus co-receptor variants associated with resistance to virus infection |
| US6399078B1 (en) | 1998-06-01 | 2002-06-04 | University Of Maryland Biotechnology Institute | Chemokine—glycosaminoglycan complexes and their use in treating or preventing receptor mediated diseases |
| US6727349B1 (en) | 1998-07-23 | 2004-04-27 | Millennium Pharmaceuticals, Inc. | Recombinant anti-CCR2 antibodies and methods of use therefor |
| US6696550B2 (en) | 1998-07-23 | 2004-02-24 | Millennium Pharmaceuticals, Inc. | Humanized anti-CCR2 antibodies and methods of use therefor |
| US6312689B1 (en) | 1998-07-23 | 2001-11-06 | Millennium Pharmaceuticals, Inc. | Anti-CCR2 antibodies and methods of use therefor |
| WO2000029556A2 (en) * | 1998-11-17 | 2000-05-25 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Identification of glycosphingolipids that promote hiv-1 entry into cells |
| DK1144006T3 (da) * | 1998-12-16 | 2007-11-26 | Progenics Pharm Inc | Synergistisk inhibering af HIV-1-fusion og -binding, præparater og antistoffer dertil |
| EP1900376A3 (de) * | 1998-12-16 | 2008-10-15 | Progenics Pharmaceuticals, Inc. | Synergistische Hemmung der HIV-1-Fusion sowie Befestigung, Zusammensetzungen und Antikörper dafür |
| WO2000040964A1 (en) * | 1999-01-08 | 2000-07-13 | The Government Of The United States Of America, As Represented By The Secretary Of Health And Human Services, National Institutes Of Health | Inhibition of cd4-ccr5 interaction |
| JP2000229997A (ja) | 1999-02-10 | 2000-08-22 | Nissui Pharm Co Ltd | 環状ペプチド及びエイズワクチン |
| US7115262B1 (en) | 1999-03-16 | 2006-10-03 | The United States Of America As Represented By The Department Of Health And Human Services | Chimeric protein for prevention and treatment of HIV infection |
| ATE407146T1 (de) * | 1999-03-16 | 2008-09-15 | Us Gov Health & Human Serv | Ein neues chimäres protein für die prävention und die behandlung einer hiv infektion |
| AU6941000A (en) * | 1999-08-27 | 2001-03-26 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Polypeptides that bind hiv gp120 and related nucleic acids, antibodies, compositions, and methods of use |
| US7304127B2 (en) | 1999-08-27 | 2007-12-04 | United States Of America As Represented By The Secretary, Department Of Health And Human Services | Polypeptides that bind HIV gp120 and related nucleic acids, antibodies, compositions, and methods of use |
| CA2389196A1 (en) * | 1999-10-28 | 2001-05-03 | Nissui Pharmaceutical Co., Ltd. | Cyclic peptides and aids vaccines |
| US20030049251A1 (en) * | 1999-12-08 | 2003-03-13 | Barbas Carlos F. | Methods and compositions useful for inhibiting ccr5-dependent infection of cells by hiv-1 |
| GB9930443D0 (en) | 1999-12-22 | 2000-02-16 | King S College London | Novel use of heat shock proteins |
| US7138119B2 (en) | 2000-09-15 | 2006-11-21 | Progenics Pharmaceuticals, Inc. | Compositions and methods for inhibition of HIV-1 infection |
| US7175988B2 (en) | 2001-02-09 | 2007-02-13 | Human Genome Sciences, Inc. | Human G-protein Chemokine Receptor (CCR5) HDGNR10 |
| US7060273B2 (en) | 2001-04-06 | 2006-06-13 | Progenics Pharmaceuticals, Inc. | Methods for inhibiting HIV-1 infection |
| US7393934B2 (en) | 2001-12-21 | 2008-07-01 | Human Genome Sciences, Inc. | Human G-protein chemokine receptor (CCR5) HDGNR10 |
| US7122185B2 (en) | 2002-02-22 | 2006-10-17 | Progenics Pharmaceuticals, Inc. | Anti-CCR5 antibody |
| CA2559809A1 (en) | 2004-03-12 | 2005-11-10 | Human Genome Sciences, Inc. | Antibodies against human g-protein chemokine receptor (ccr5) hdgnr10 |
| KR20080035653A (ko) | 2005-07-22 | 2008-04-23 | 프로제닉스 파머슈티컬스, 인코포레이티드 | Ｈｉｖ―１ 감염 환자에서 바이러스 부하를 감소시키는방법 |
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|---|---|---|---|---|
| US5126433A (en) * | 1986-08-21 | 1992-06-30 | The Trustees Of Columbia University In The City Of New York | Soluble forms of the t cell surface protein cd4 |
| US5869624A (en) * | 1993-03-26 | 1999-02-09 | Progenics Pharmaceuticals, Inc. | HIV-1 vaccines, antibody compositions related thereto, and therapeutic and prophylactic uses thereof |
| AU695565B2 (en) * | 1993-12-17 | 1998-08-13 | Progenics Pharmaceuticals, Inc. | Methods for using resonance energy transfer-based assay of HIV-1 envelope glycoprotein-mediated membrane fusion, and kits for practicing same |
| AU2663295A (en) * | 1995-06-06 | 1996-12-24 | Human Genome Sciences, Inc. | Human g-protein chemokine receptor hdgnr10 |
| US6261763B1 (en) * | 1995-06-07 | 2001-07-17 | Progenics Pharmaceuticals, Inc. | Fluorescence resonance energy transfer screening assay for the identification of compounds that are capable of abrogating macrophage-tropic HIV-1 cell fusion |
| EP0883687B1 (de) * | 1996-03-01 | 2004-10-27 | Euroscreen S.A. | Cc-chemokinzeptor c-c ckr-5, dessen derivate und verwendungen |
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1997
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- 1997-06-13 AU AU33902/97A patent/AU3390297A/en not_active Abandoned
- 1997-06-13 CA CA002257991A patent/CA2257991A1/en not_active Abandoned
- 1997-06-13 AU AU34026/97A patent/AU735460B2/en not_active Ceased
- 1997-06-13 WO PCT/US1997/010619 patent/WO1997047319A1/en not_active Ceased
- 1997-06-13 EP EP97930120A patent/EP0956044A4/de not_active Withdrawn
- 1997-06-13 WO PCT/US1997/010233 patent/WO1997047318A1/en not_active Ceased
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8168663B2 (en) | 2002-12-19 | 2012-05-01 | The Scripps Research Institute | Pharmaceutically acceptable salt of 6-carboxy-2-(3,5 dichlorophenyl)-benzoxazole, and a pharmaceutical composition comprising the salt thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| AU735460B2 (en) | 2001-07-12 |
| JP2001503608A (ja) | 2001-03-21 |
| WO1997047318A1 (en) | 1997-12-18 |
| EP0956044A4 (de) | 2005-01-05 |
| WO1997047319A1 (en) | 1997-12-18 |
| AU3402697A (en) | 1998-01-07 |
| AU3390297A (en) | 1998-01-07 |
| EP0956044A1 (de) | 1999-11-17 |
| CA2257991A1 (en) | 1997-12-18 |
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