JP4173841B2 - Chemical inspection equipment - Google Patents

Description

  The present invention relates to a chemical test apparatus, and in particular, measures nitric oxide (hereinafter referred to as NO) at a specific site inside a body cavity or blood vessel for the purpose of elucidating, diagnosing, or treating a circulatory system disease. The present invention relates to a chemical test apparatus including a nitric oxide sensor (hereinafter referred to as a NO sensor) that can be used, and a medical tube in which a NO sensor is attached to a tip portion.

  In recent years, with respect to many diseases such as hypertension, hyperlipidemia, diabetes, etc., production or regulation of NO is inhibited, so that arteriosclerosis has progressed and serious diseases such as ischemic heart disease and cerebrovascular disorder have occurred. It has become clear that it leads to symptoms. Measuring the concentration of NO at a specific site in the body is important for knowing abnormalities in the production or regulation of NO and for diagnosing and treating related diseases, particularly cardiovascular diseases.

  Since NO produced in the body is rapidly metabolized, not only its life span is very short, but also the concentration of NO changes from time to time due to hemodynamics and the influence of other physiologically active substances. This measurement is not useful for diagnosis. In other words, in vitro tests are not useful for diseases in which NO concentration is diagnostically important, and in vivo chemical tests are required in the deep part of the body, such as in blood vessels and body cavities.

  About chemical testing equipment that can safely measure the NO concentration every moment in blood vessels, body cavities, etc., and can diagnose vascular diseases by NO concentration in the body without destroying or damaging blood vessel walls, body cavity walls, etc. Japanese Patent Application No. 2003-310540 filed earlier by the applicant of the present application.

  The chemical inspection apparatus described in Japanese Patent Application No. 2003-310540 includes a portable inner layer tube, a portable outer layer tube that covers the inner layer tube, and NO that detects NO in the liquid at the tip of the inner layer tube. It consists of a sensor, and the outer layer tube is movable in the length direction so that the NO sensor can be exposed and stored. The NO sensor is provided with an insertion elastic body at its distal end, and the insertion elastic body has an outer diameter that is the same as or slightly larger than the outer diameter of the outer tube, It has a conical shape whose outer diameter tapers from its proximal end toward its distal end and has flexibility, and when inserted into a measurement site in the body, The thing which can protect a NO sensor is proposed by contact | abutting with the front-end | tip part of an outer layer tube.

However, the chemical inspection apparatus of Japanese Patent Application No. 2003-310540 has been found to have room for improvement in the following points based on development studies thereafter.
(1) Since it has a double structure of inner tube and outer tube, and an insertion elastic body is provided, the outer diameter is inevitably thick, making it difficult to insert into a body cavity or blood vessel with a narrow inner diameter. There is a limit.
(2) Since the inner layer tube and the outer layer tube have a double structure, the outer diameter of the tube portion inevitably increases, and the shape of the insertion elastic body increases accordingly, so that insertion into a body cavity or blood vessel is possible. Difficult to damage body cavities and blood vessels.
(3) Since it has a double structure, its shape increases, insertion operability into body cavities, blood vessels, etc. decreases, and it takes a lot of time to insert the measurement site, which hinders diagnosis and treatment. is there.
(4) In the case where the insertion elastic body is provided at the tip of the NO sensor, it takes a long time to insert the measurement site when inserting into a body cavity, blood vessel, or the like, and the insertion is difficult.
(5) Since it has a double structure, the NO sensor is mounted and fixed in the inner layer tube, and the outer tube is provided on the outer periphery thereof, the flexibility of the mounting and fixing portion is insufficient, making insertion difficult.

  Therefore, the object of the present invention is to improve the above-mentioned points, smooth insertion into body cavities and blood vessels, good operability, easy insertion into body cavities and blood vessels of small inner diameter, and measurement of NO concentration in the body. An object of the present invention is to provide a chemical test apparatus capable of expanding the scope of diagnosis and treatment of vascular diseases caused by the above.

  In order to achieve the above object, the present invention provides a flexible tube, a NO sensor that is attached to one end of the tube and detects NO in the liquid, and directly or via a support at the tip of the tube. A chemical inspection apparatus characterized by having a guide wire insertion hole through which the guide wire is inserted. .

A preferred embodiment of the present invention has the following features.
A. The insertion elastic body includes a base portion that covers the NO sensor distal end portion, a distal end portion through which the guide wire is inserted, and a connecting portion that connects the base portion and the distal end portion. The connecting portion is configured to be shifted from the central axis of the base portion by approximately 1/4 to 3 / 4R (R: the diameter of the base portion).
B. The outer diameter of the base is the same as the outer diameter of the tube, the outer diameter of the distal end is approximately 1/2 of the outer diameter of the tube, and the guide wire insertion hole extends from the base. A predetermined taper is formed over the tip.
C. The insertion elastic body is formed of a thermoplastic resin composition having a Shore D hardness of 20 to 50.
D. The insertion elastic body is made of an alloy material having elasticity and repulsion, and includes a spiral portion formed in a conical spiral body, an end portion fixed to the distal end portion of the tube, the spiral portion, and the end portion. And a support part for connecting the two.
E. The support is formed by a cylindrical body having a window portion, and the NO sensor portion is positioned in the window portion.
F. The support is formed of a nickel / titanium alloy or a stainless steel material coated with a thermoplastic resin composition.
G. The support is formed from a polyamide elastomer resin composition.
H. The tube is made of a thermoplastic resin composition having flexibility, and has a reinforcing body braided or laterally wound in the wall.

  In order to achieve the above object, the present invention provides a tube made of a high-strength and superelastic alloy material having a coating layer inside and outside, a NO sensor that is attached to one end of the tube and detects NO in the liquid, An insertion elastic body that is fixed to the distal end portion of the tube and covers the distal end portion of the NO sensor, and the distal end portion of the tube has a window portion that allows liquid to flow into the tube. And the window sensor is configured such that the NO sensor is positioned, and the insertion elastic body has a guide wire insertion hole through which the guide wire is inserted. To do.

In a preferred embodiment of the present invention, in addition to the features A to D described above, the following features are provided.
I. The said coating layer consists of a plastic coating layer, and the thickness shall be 0.1 mm or less.
J. et al. The alloy material is made of a nickel-titanium alloy material, the blending ratio thereof is in the range of 35:65 to 55:45, and the thickness thereof is comprised between 0.10 and 0.20 mm.

According to the present invention, a chemical inspection apparatus having the following effects can be provided.
1. The tube outer diameter and the insertion elastic body outer diameter of the chemical inspection apparatus can be reduced.
2. Insertion into a body cavity having a small inner diameter is facilitated, and the range of diagnosis and treatment is expanded.
3. Damage to body cavities and blood vessels during insertion is reduced.
4). The time required for insertion can be shortened.
5. The flexibility and operability of chemical testing equipment can be improved.

Hereinafter, embodiments of the present invention will be described with reference to the drawings.
(First embodiment)
FIG. 1 is an overall schematic configuration diagram of a chemical testing apparatus according to a first embodiment of the present invention, and a part thereof is shown in cross section.

  The chemical testing apparatus 1 includes a tube 10, a NO sensor 20 attached and fixed to the distal end portion thereof, an insertion elastic body 30 </ b> A disposed at the distal end of the NO sensor 20, and an insertion elastic body 30 </ b> A disposed and fixed at the distal end portion of the tube 10. The connecting wire 40 connected to the lead wire of the NO sensor 20 passed through the inside of the tube 10, and connected to the base end portion of the tube 10 via the connecting body 50, and to the other end of the wire 60. It is schematically composed of a plug connector 61 attached.

  FIG. 2 is a cross-sectional view showing the distal end portion of the chemical testing apparatus according to the first embodiment of the present invention. The NO sensor 20 is fixed to the distal end of the tube 10 and is disposed at the distal end portion of the NO sensor 20. The insertion elastic body 30A is shown fixed to the tip of the tube by a support 40. The configuration of each part will be described below.

  The tube 10 is appropriately adjusted in length, thickness, material, etc. For example, a polyamide elastomer having an inner diameter of 1.0 mm, an outer diameter of 1.4 mm, a length of about 1100 mm, and a Shore D hardness of 50 to 70. It consists of a thermoplastic resin composition having flexibility such as resin.

  Moreover, it is preferable that the tube 10 has the reinforcement body 12 embed | buried in the wall body, and the reinforcement body 12 is comprised by the braided body or side winding. Thereby, since the tube 10 is not twisted and crushed, the reliability of the chemical test apparatus 1 is increased. In order to fix the support body 40 by heat welding, it is preferable that the front-end | tip part of the tube 10 forms the flexible part 11 in which the reinforcement body 12 is not embed | buried.

  For the NO sensor 20, for example, the NO sensor described in Japanese Patent Application No. 2002-372615 filed earlier by the applicant of the present application is used.

  FIG. 7 is a diagram showing a specific example of the NO sensor used in the present invention, and is described in Japanese Patent Application No. 2002-372615. The NO sensor 20 includes a sheath tube 110 made of a fluororesin that transmits low molecules such as NO, an electrolyte solution 120 filled therein, a carbon electrode 130 immersed therein, and the sheath tube 110. The sensor is constituted by a comparison electrode 140 provided in close contact with the base side and an insulator 150 that covers the periphery of the comparison electrode 140 so that the comparison electrode 140 is not exposed. The carbon electrode 130, the reference electrode 140, and the insulator 160 are connected to the insulated lead wires 500, 600, and 700, respectively, and the insulated lead wire 700 is for a ground wire. The signal based on the NO detection value is not limited to the signal transmitted by an electric signal such as a potential difference, and may be transmitted by an optical signal, for example.

  The insertion elastic body 30A is made of, for example, a thermoplastic resin composition such as a polyamide elastomer resin, and has a substantially conical shape with a base diameter of 1.4 mm, a tip diameter of 0.7 mm, and a length of 20 mm. Preferably, it is formed by injection molding from a polyamide elastomer resin or polyurethane resin having a Shore D hardness of 20 to 50 degrees. Here, the Shore D hardness of 20 or more and 50 or less is too soft if it is less than 20, the shape is changed during insertion and discharge, and the operability is significantly reduced. This is because it cannot follow the shape change and cannot be inserted.

  Inside the base 74 of the insertion elastic body 30A, a sensor insertion hole 71 in which the NO sensor 20 is disposed and a support fixing hole 72 to which the support 40 is fixed are provided.

  The insertion elastic body 30 </ b> A is provided with an insertion hole 70 </ b> A having a diameter of 0.45 mm formed from a part of the outer peripheral portion of the base portion 74 to the distal end portion 73. A guide wire, which will be described later, is inserted into the insertion hole 70A to facilitate insertion into a body cavity, blood vessel, or other internal measurement site at the tip of the chemical testing apparatus.

  In addition, the insertion elastic body 30A has a distal end portion 73 and a base portion so that the insertion and withdrawal positions of the guide wire are located as close to the insertion elastic body 30A as possible so that the insertion elastic body 30A can be easily inserted into a body cavity, blood vessel or the like. 74 and a connecting portion 75 that connects the distal end portion and the base portion, and the central axis of the distal end portion 73 is shifted by about 1/2 R (R: diameter of the base portion 74) from the central axis of the base portion 74 by the connecting portion 75. It is formed. It is not limited to about 1 / 2R, but is preferably shifted within a range of about 1/4 to 3/4, and more preferably within a range of about 1/4 to 2/3.

  The outer diameter of the base portion 74 is approximately the same as the outer diameter of the tube 10, the outer diameter of the distal end portion 73 is approximately 1/2 of the tube 10, and the insertion hole 70 </ b> A through which the guide wire is inserted is substantially from the base portion 74. It is configured with a taper of 5 to 10 degrees from the outer periphery of the base at a position separated to the 1/3 tip side to the center of the tip part. As a result, the insertion position of the guide wire does not exceed the outer diameter of the insertion elastic body, and the protruding position of the guide wire protrudes from the center of the distal end of the insertion elastic body, so that the insertion outer diameter does not increase even when the guide wire is applied.

  3 (a) and 3 (b) are perspective views showing a support of the chemical testing apparatus according to the first embodiment of the present invention.

  The support 40 is made of, for example, a heat-resistant material such as polyethylene terephthalate resin in order to eliminate the influence of body fluid, blood, etc. on a cylindrical body obtained by punching a highly elastic nickel / titanium alloy material or stainless steel material. A coating layer is provided with a plastic plastic resin composition.

  The support 40 may be made of a thermoplastic resin composition such as a polyamide elastomer resin, and the hardness at that time may be selected from the range of Shore D hardness 50-70. When the support body 40 is made of polyamide elastomer resin, the fixing portion with the insertion elastic body 30A and the fixing portion with the tube 10 do not become hard, and the flexibility of each fixing portion can be enhanced. When the support body 40 is made of a polyamide elastomer resin, the insertion elastic body 30A and the tube 10 are fixed by heat welding.

  The support body 40 is constituted by a cylindrical body having an outer diameter of 1.1 mm, a length of 25 mm, a thickness of 0.15 mm, and the like, and at least two or more window portions 43 are provided in the middle portion excluding both ends 41 and. The NO sensor 20 is located in the window 43. In order for the NO sensor 20 inside the support 40 to be in sufficient contact with the body fluid to be measured, it is preferable to make the window 43 large. However, if the support 44 becomes too thin, it becomes difficult to support, so that the adjustment is appropriately made. Is desirable. Only one large window 43 may be provided.

  The support 40 has an upper end 41 fixed to the support fixing hole 72 of the base 74 of the insertion elastic body 30A by heat welding or an adhesive, and the other lower end 42 is inserted into the tube 10 for heat welding or adhesion. Fix with an agent. The fixing method of the lower end portion 42 may be fixed to the outer periphery of the tube 10 and is not limited, but is preferably fixed to the inside of the tube 10 so as not to increase the diameter. The NO sensor 20 inside the support 40 is inserted into the sensor insertion hole 71 of the insertion elastic body 30A and is not directly fixed.

(Second Embodiment)
FIG. 4 (a) is a cross-sectional view showing the tip of the chemical testing apparatus according to the second embodiment of the present invention, and FIG. 4 (b) is a chemistry according to the second embodiment of the present invention. It is a side view which shows the insertion elastic body of a test | inspection apparatus.

  The insertion elastic body 30B is made of an alloy material having elasticity and repulsion, for example, a metal wire made of stainless steel wire having a thickness of 0.2 to 0.4 mm, and a spiral portion 31B positioned at the tip portion and a central portion. It is comprised from the support part 34B located in 1 and the edge part 32 located in a base. Each part may be molded as a single body or may be molded by heat welding using different materials.

  The spiral portion 31B is formed in a conical spiral body and has a guide wire insertion hole 70B. For example, the base diameter is 1.4 mm, the tip diameter is 0.7 mm, the length is 20 mm, and the spiral pitch is 0.1 to 0.00. It is formed at 2 mm. The shape is not limited to the striate body, but may be a foil or any other shape.

  As in the first embodiment, the guide wire insertion hole 70B is provided so that the NO sensor 20 can be inserted in close proximity to the guide wire, and the central axis of the spiral portion 31B is the central axis of the tube 10. By shifting about 1 / 2R (R: the diameter of the tube 10) from the base, it is possible to insert the guide wire from the space of the base of the spiral portion 31B that is largely open toward the tip. It is not limited to about 1 / 2R, but is preferably shifted within a range of about 1/4 to 3/4, and more preferably within a range of about 1/4 to 2/3.

  The support portion 34B has a function of the support portion 44 of the support body 40 according to the first embodiment, and the end portion 32 has a function of the lower end portion 42 of the support body 40 according to the first embodiment. Since the end 32 is fixed inside the tube 10, the support body 40 according to the first embodiment is not necessary, and the insertion elastic body 30 </ b> B is directly fixed to the tip of the tube 10. It will be. As a result, the number of constituent members is reduced, and the structure can be simplified.

  The fixing of the end portion 32 to the tube 10 is not particularly limited. For example, the end portion 32 is inserted into the tube 10 and the cylindrical body 35B made of thermoplastic resin is inserted into the end portion 32. Then, the tube 10, the end 32, and the cylindrical body 35B are fixed with an adhesive. The end 32 may be fixed to the reinforcing body 12 in the wall of the tube 10 by welding. The NO sensor 20 has an insulator 36 and is fixed at the tip of the tube 10.

(Third embodiment)
FIG. 5 (a) is a cross-sectional view showing a tip portion of a chemical testing apparatus according to the third embodiment of the present invention, and FIG. 5 (b) is a chemical diagram according to the third embodiment of the present invention. It is a side view which shows the front-end | tip part of a test | inspection apparatus.

  The chemical inspection apparatus according to the third embodiment is the second embodiment because the thickness of the metal wire used for the insertion elastic body 30C is reduced and the stainless steel wire 33 is used as the reinforcement. It is different from such a chemical inspection apparatus. Since the other points are the same as in the second embodiment, only this difference will be described below.

  The insertion elastic body 30C uses a metal wire made of a stainless steel wire having a thickness of 0.1 to 0.2 mm, and has a helical portion 31C located at the distal end, a support portion 34C located at the central portion, and a base portion. And an end portion 32.

  The spiral portion 31C of the insertion elastic body 30C has a stainless steel wire 33 having a strand diameter of 0.1 to 0.2 mm for suppressing the extension in the length direction of the spiral portion 31C fixed to the base portion from the distal end thereof. It extends to the end portion 32 in parallel with the support portion 34C and is thermally welded to the end portion 32, and the end portion 32 is fixed to the inner wall of the tube 10. The end portion of the stainless steel wire 33 may be directly fixed to the inner wall of the tube 10 together with the end portion 32 without being thermally welded to the end portion 32. The stainless steel wire 33 is not required if the insertion elastic body 30C is formed of a nickel / titanium alloy material, which is relatively difficult to cause plastic deformation.

(Fourth embodiment)
FIG. 6 (a) is a cross-sectional view showing a tip portion of a chemical testing apparatus according to the fourth embodiment of the present invention, and FIG. 6 (b) is a chemical diagram according to the fourth embodiment of the present invention. It is a perspective view which shows the front-end | tip part of a test | inspection apparatus.

  In the fourth embodiment of the present invention, a composite tube 15 is used instead of the tube 10. The composite tube 15 is made of polyester having a thickness of 0.05 mm on the inner and outer surfaces of an alloy tube 16 made of a nickel-titanium alloy material of high strength and superelasticity with an inner diameter of 0.80 mm, an outer diameter of 1.1 mm, and a length of 1200 mm. It is configured by covering plastic coating layers 16A and 16B such as resin or polyamide elastomer resin. The wall thickness of the coating layer is preferably 0.1 mm or less. The insertion elastic body 30 </ b> A is directly fixed to the upper end portion 41 which is one end of the composite tube 15 through the tube fixing hole 76. According to such a configuration, it is possible to obtain a chemical inspection apparatus in which the outer diameter of the tube is reduced and the outer diameter of the insertion elastic body fixing portion is not increased.

  The composite tube 15 is provided with one, preferably a plurality of window portions 43 at the tip thereof, the NO sensor 20 is positioned in the window portion 43, the NO sensor 20 is fixed to the tip portion of the composite tube 15, and insertion elasticity The tip of the NO sensor 20 is protected by the body 30 </ b> A and the support portion 44 of the composite tube 15. This eliminates the need for the support 40 described above, simplifies the configuration of the chemical inspection apparatus, and enables further miniaturization. The window portion 43 is formed by polishing and cutting, and the place where the window portion 43 is formed is coated with a plastic coating layer.

  The alloy tube 16 constituting the composite tube 15 preferably has a nickel: titanium mixing ratio in the range of 35:65 to 55:45, with 45:55 being from the viewpoint of flexibility, repulsion, operability, and the like. Particularly preferably, the thickness is preferably from 0.10 to 0.20 mm, particularly preferably from 0.10 to 0.15 mm.

  In the present embodiment, the insertion elastic body 30A is applied, but the above-described insertion elastic bodies 30B, 30C and the like can also be applied.

  FIG. 8 is a diagram showing a case where the chemical test apparatus of the present invention is actually applied to the measurement of NO concentration inside the body cavity.

  The guide wire 90 inserted into the guide wire insertion hole of the insertion elastic body is formed of a 0.35 mm diameter wire made of a stainless alloy material having elasticity and repulsion, and the insertion tip has flexibility and repulsion. The tip part which has is provided and is generally used.

  As a method of use, for example, a guide wire 90 is inserted from the artery 80 of the buttocks, and is allowed to reach the blood vessel of the target site 91 through the aorta 81, and the connector 61 of the chemical test apparatus is connected to a signal processing unit (not shown). , The base of the guide wire 90 is passed through the insertion hole of the insertion elastic body 30, the chemical testing device is inserted into the blood vessel, reaches the target site along the guide wire 90, and the NO sensor 20 is inserted into the blood vessel. NO is generated, and an oxidation current is generated and converted into NO concentration by the signal processing unit and measured. A doctor diagnoses the presence or absence of a disease in the blood vessel from the measured NO concentration.

1 is an overall schematic configuration diagram of a chemical testing apparatus according to a first embodiment of the present invention. It is sectional drawing which shows the front-end | tip part of the chemical testing apparatus which concerns on the 1st Embodiment of this invention. (A) And (b) is a perspective view which shows the support body of the chemical testing apparatus which concerns on the 1st Embodiment of this invention. (A) is sectional drawing which shows the front-end | tip part of the chemical testing apparatus which concerns on the 2nd Embodiment of this invention, (b) is insertion of the chemical testing apparatus which concerns on the 2nd Embodiment of this invention. It is a side view which shows an elastic body. (A) is sectional drawing which shows the front-end | tip part of the chemical testing apparatus which concerns on the 3rd Embodiment of this invention, (b) is the front-end | tip of the chemical testing apparatus which concerns on the 3rd Embodiment of this invention. It is a side view which shows a part. (A) is sectional drawing which shows the front-end | tip part of the chemical testing apparatus which concerns on the 4th Embodiment of this invention, (b) is the front-end | tip of the chemical testing apparatus which concerns on the 4th Embodiment of this invention. It is a perspective view which shows a part. It is a figure which shows the specific example of the NO sensor used by this invention. It is a figure which shows the case where the chemical test | inspection apparatus of this invention is actually applied to NO density | concentration measurement inside a body cavity.

Explanation of symbols

1: Chemical inspection apparatus 10: Tube 11: Flexible portion 12: Reinforcement body 15: Composite tube 16A, 16B: Plastic coating layer 16: Alloy tube 20: NO sensors 30, 30A, 30B, 30C: Insert elastic bodies 31B, 31C: Spiral portion 32: end portion 33: stainless steel wire 34B, 34C: support portion 35B, 35C: cylindrical body 36: insulator 40: support body 41: upper end portion 42: lower end portion 43: window portion 44: support portion 50: connection Body 60: Electric wire 61: Connectors 70A, 70B, 70C: Insertion hole 71: Sensor insertion hole 72: Support body fixing hole 73: Tip part 74: Base part 75: Connection part 76: Tube fixing hole 80: Artery 81: Aorta 90: Guide wire 91: Target part 110: Outer tube 120: Electrolytic solution 130: Carbon electrode 140: Comparative electrode 150, 160: Insulator 500, 600, 700 Insulated lead wire

Claims (12)

A flexible tube;
A nitric oxide sensor (hereinafter referred to as NO sensor) that is attached to one end of the tube and detects nitric oxide (hereinafter referred to as NO) in the liquid;
An insertion elastic body fixed directly or via a support to the tip of the tube,
The chemical inspection apparatus, wherein the insertion elastic body has a guide wire insertion hole through which the guide wire is inserted. The insertion elastic body includes a base that covers the tip of the NO sensor, a tip through which the guide wire is inserted, and a connecting portion that connects the base and the tip.
2. The center axis of the tip portion is configured to be shifted from the center axis of the base portion by approximately 1/4 to 3 / 4R (R: diameter of the base portion) by the connecting portion. Chemical testing equipment.   The outer diameter of the base is the same as the outer diameter of the tube, the outer diameter of the distal end is approximately 1/2 of the outer diameter of the tube, and the guide wire insertion hole extends from the base. 3. The chemical inspection apparatus according to claim 2, wherein the chemical inspection apparatus is configured to have a predetermined taper over a tip portion.   4. The chemical inspection apparatus according to claim 1, wherein the insertion elastic body is formed of a thermoplastic resin composition having a Shore D hardness of 20 to 50. 5.   The insertion elastic body is made of an alloy material having elasticity and repulsion, and includes a spiral portion formed in a conical spiral body, an end portion fixed to the distal end portion of the tube, the spiral portion, and the end portion. The chemical inspection apparatus according to claim 1, wherein the chemical inspection apparatus has a support portion that connects the two.   The chemical test apparatus according to claim 1, wherein the support is formed of a cylindrical body having a window portion, and the NO sensor portion is positioned in the window portion.   The chemical inspection apparatus according to claim 6, wherein the support is made of a nickel / titanium alloy or a stainless steel material coated with a thermoplastic resin composition.   The chemical inspection apparatus according to claim 6, wherein the support is formed of a polyamide elastomer resin composition.   The chemical inspection apparatus according to claim 1, wherein the tube is made of a thermoplastic resin composition having flexibility, and has a reinforcing body braided or horizontally wound in the wall. A tube made of a high-strength and superelastic alloy material having a coating layer inside and outside;
A NO sensor attached to one end of the tube to detect NO in the liquid;
An insertion elastic body fixed to the tip of the tube and covering the tip of the NO sensor,
The distal end portion of the tube has a window portion that allows liquid to flow into the tube, and the NO sensor portion is positioned in the window portion,
The chemical inspection apparatus, wherein the insertion elastic body has a guide wire insertion hole through which the guide wire is inserted.   The chemical inspection apparatus according to claim 10, wherein the coating layer is made of a plastic coating layer and has a thickness of 0.1 mm or less. The alloy material is made of a nickel-titanium alloy material, the blending ratio thereof is in the range of 35:65 to 55:45, and the thickness thereof is constituted by 0.10 to 0.20 mm. The chemical inspection apparatus according to claim 10.