JP3771553B2 - Chemical inspection equipment - Google Patents

Description

  The present invention relates to a chemical test apparatus, and in particular, for example, nitric oxide (hereinafter referred to as NO) at a specific site in a body cavity or blood vessel for elucidation, diagnosis and treatment of a circulatory system disease. The present invention relates to a chemical test apparatus useful for chemical tests in the deep part of the body, comprising a NO sensor capable of measuring the concentration of each component, a temperature sensor, and the like.

In recent years, with respect to many diseases such as hypertension, hyperlipidemia, diabetes, etc., production or regulation of NO is inhibited, so that arteriosclerosis has progressed and serious diseases such as ischemic heart disease and cerebrovascular disorder have occurred. It has become clear that it leads to symptoms. Administration of nitroglycerin is well known as a treatment method for angina pectoris, and this is a treatment method for adjusting NO concentration in the body.
Measuring the NO concentration at a specific site in the body is important for knowing abnormalities in production or regulation of NO and for diagnosing and treating related diseases, particularly cardiovascular diseases.

  Since NO produced in the body is rapidly metabolized, not only its life span is very short, but also the concentration of NO changes from time to time due to hemodynamics and the influence of other physiologically active substances. This measurement is not useful for diagnosis. In other words, in vitro tests are not useful for diseases in which NO concentration is diagnostically important, and in vivo chemical tests are required in the deep part of the body, such as in blood vessels and body cavities.

  As a conventional chemical test apparatus used for measurement in a deep part of a body such as a blood vessel or a body cavity, for example, there is a catheter that can be measured in the heart and the vascular system (see Patent Document 1).

FIG. 11 shows a conventional chemical inspection apparatus described in Patent Document 1. This chemistry system, a flexible tube 81, a guide wire Layer 8 3 through its tube, a metal sleeve 85 which is wound helically around it, the tube of the base of the flexible tube 81 in a metal tube 86 which is provided, consists of a pressure sensor 82 provided at the tip portion of the flexible tube 81, optical fibers 84 to the guide wire Layer 8 3 for transmitting an optical signal corresponding to the pressure from the pressure sensor 82 is It has been incorporated. Flexible tube 81 is a polymer tube having a thin wall, the guide wire Ya 8 3 is a metal wire which is rich in flexibility and elasticity. The distal end of the guide wire Layer 8 3 protruding from the distal end of the flexible tube 81, is added tip portion 87 rounded, between the tip of the distal end portion 87 and the flexible tube 81 is a helix line 88 It is connected.

Conventional chemistry apparatus described in Patent Document 1, the guide for the wire Ya is rich in flexibility and elasticity, can prevent damage to the vessel wall or the like when inserting, and the pressure sensor and guide wire Ya dimensions It is described that it is possible to measure the pressure of a part of the heart and vasculature that has been unreachable with a catheter so far.

  In addition, NO sensors, blood vessel walls, etc. are not destroyed or damaged, and it is possible to safely measure the NO concentration in the deep part of the body, such as in blood vessels and body cavities, to diagnose vascular diseases related to the NO concentration in the body. As a possible chemical inspection apparatus, there is an unpublished Japanese Patent Application No. 2002-372615 by the applicant of the present application.

  The chemical test apparatus described in Japanese Patent Application No. 2002-372615 includes a flexible catheter tube, a NO sensor that is provided on the distal end side of the catheter tube and detects NO in the liquid, and an opening through which the liquid flows. And a protective body that covers the NO sensor, and the catheter can be inserted into the deep part of the body such as in a blood vessel or body cavity without damaging or destroying the blood vessel wall or the NO sensor. Can measure the NO concentration every moment and can diagnose vascular diseases related to NO concentration in the body.

  On the other hand, the inner tube stored in the outer tube of the double tube structure can slide so that the tip of the inner tube protrudes from the tip of the outer tube to a predetermined length. There exists patent document 2 as a catheter.

  Patent Document 2 is a sliding catheter that has a slidable double tube structure composed of an inner tube and an outer tube, and the tip of the inner tube protrudes from the tip of the outer tube by a predetermined length. A fixed length of at least the proximal side of the inner tube is made of metal, one end of the balun tube is fixed to the tip of the inner tube, and the other end of the balun tube is fixed to the tip of the outer tube. A sliding catheter is disclosed in which a relative distance scale between the proximal end of the outer tube and the proximal end of the inner tube and a relative rotational angle are attached to the proximal end portion of the sliding catheter.

  According to the present invention, since the inner tube is made of a superelastic alloy or the like, the diameter of the inner tube that is required to have a waist can be reduced, thereby reducing the diameter of the outer tube and making it thinner. Convenient for insertion into the sheath or endoscope, and excellent rotation follow-up performance when controlling the tip of the inner tube by operating the inner tube hub at the base end despite the thin inner tube There is an advantage that liquid injection, pressure measurement, balun expansion, etc. can be performed easily, and the inner tube made of metal, especially superelastic alloy, makes it easy to insert as a thin catheter core. There is.

Japanese Patent No. 2869534 Japanese Patent No. 3351015

  However, according to the conventional chemical test apparatus of Patent Document 1, since the sensor is accommodated in the catheter tube, it is difficult to say that the sensor is suitable for measuring the substance concentration.

Moreover, it is thought that the chemical inspection apparatus of Japanese Patent Application No. 2002-372615 still has room for improvement in the following points.
(1) Since the NO sensor is covered with a protective body, although there is an opening through which the liquid flows, the flow of liquid at the distal end of the protective body is small, so the NO detection ability decreases, The measurement accuracy of NO tends to be low.
(2) Since the NO sensor is attached to the distal end of the catheter and the protective body is provided on the outer periphery of the NO sensor, the insertion into the blood vessel or body cavity tends to be not smooth.
(3) Since the NO sensor is attached to the tip of the catheter and a protective body is provided on the outer periphery of the NO sensor, both the blood vessel wall, the body cavity wall, etc. and the NO sensor are damaged during insertion into a blood vessel or body cavity. There is still the danger of destroying it.

  In Patent Document 2, an inner tube housed in an outer tube having a double tube structure is slid so that the tip of the inner tube protrudes from the tip of the outer tube by a predetermined length. However, the balun tube is attached to the tip of the sliding catheter, and the other end is just a scale of the relative distance between the proximal end of the outer tube and the proximal end of the inner tube and a scale of the relative rotation angle. No medical tube is disclosed.

  Therefore, the object of the present invention is to smoothly insert into blood vessels and body cavities, and safely and from time to time in the deep part of the body, such as in blood vessels and body cavities, without destroying or damaging the NO sensor and blood vessel walls. It is an object of the present invention to provide a chemical test apparatus that can measure the NO concentration of the blood vessel and can accurately diagnose vascular diseases related to the NO concentration in the body.

In order to achieve the above object, the present invention provides a flexible inner layer tube, a NO sensor for detecting NO in a liquid attached to the tip of the inner layer tube, an outer periphery of the NO sensor, and the inner layer tube The NO sensor has an outer periphery covered by the outer layer tube when inserted into a measurement site inside the body, and the inner layer tube is covered at the measurement site. The chemical inspection apparatus is characterized in that the end is moved and exposed from the outer layer tube.
According to the present invention, when inserted into a measurement site in a body cavity, the outer periphery of the NO sensor is covered, and the NO sensor is exposed by protruding from the outer tube at the measurement site, so that measurement can be performed with high accuracy, and It becomes possible to reduce the damage of the NO sensor.

In a preferred aspect of the present invention, the inner layer tube has a reinforcing body in its wall, and the lead wire of the NO sensor is configured to be connected to a part of each element wire constituting the reinforcing body. The outer tube has a reinforcing member in its wall, and a part of each of the strands constituting the reinforcing member is formed of an insulated metal good conductor. Since it is only necessary to be able to connect the lead wire, the insulated metal good conductor does not have to be embedded in all the constituent wires.
According to this feature, the lead end of the NO sensor, the lead end of the temperature sensor, the lead end of the electrodes that is provided in the insertion elastic body periphery, the lead end of the pressure sensor, to organize provided outer tube electrodes, etc. It becomes possible to connect.

In a preferred aspect of the present invention, a tip of the outer layer tube is fixed to the tip of the tube, and the tip is made of a thermoplastic composition and is flexible.
According to such a feature, when the NO sensor is inserted into a blood vessel or a body cavity, the inside of the blood vessel or the body cavity can be hardly damaged.

In a preferred aspect of the present invention, the NO sensor is provided with an insertion elastic body at a distal end thereof, and the insertion elastic body has an outer diameter of the base end equal to the outer diameter of the outer layer tube, It has a slightly larger outer diameter, a conical shape whose outer diameter tapers from its proximal end toward its distal end, has flexibility, and is inserted into a measurement site in the body. Is characterized in that the NO sensor can be protected by contacting the proximal end portion of the first insertion elastic body with the distal end portion of the outer layer tube or the distal end portion of the distal end tip. To do.
According to this feature, when the NO sensor is inserted into or removed from the body cavity, damage or destruction of the NO sensor can be reduced, and insertion or removal from the body cavity can be facilitated. It becomes possible to make it difficult to damage the body cavity by insertion or removal.

In a preferred aspect of the present invention, the NO sensor is provided with an insertion elastic body at a distal end portion thereof, and the insertion elastic body is attached to the other end of the support body having one end fixed to the distal end inner diameter portion of the inner layer tube. The insertion elastic body is fixed, and an insertion portion into which the distal end portion of the NO sensor is inserted is provided at the proximal end portion of the insertion elastic body, and a part of the distal end of the NO sensor is inserted and inserted into a measurement site in the body In this case, the NO sensor can be protected by contacting the proximal end of the insertion elastic body with the distal end of the outer tube or the distal end of the distal tip.
According to this feature, it becomes possible to reduce the destruction and damage of the NO sensor due to the insertion of the NO sensor into the body cavity.

  The insertion elastic body is preferably made of an elastic plastic material. Alternatively, the insertion elastic body includes a metal elastic body and a distal end portion formed in a coiled conical shape and an insertion body base formed of an elastic plastic material.

In a preferred aspect of the present invention, the support is integrally provided with a temperature sensor for measuring the temperature in the body cavity at a substantially intermediate portion thereof, and the lead wire connected to the temperature sensor is a wall body of the inner layer tube. It is the structure connected to a part of each strand which comprises an inside reinforcement body, It is characterized by the above-mentioned. Since it is only necessary to be able to connect the lead wire, the insulated metal good conductor does not have to be embedded in all the constituent wires. Preferably, the support is configured to have a substantially L shape or a substantially U shape using a highly elastic metal material or a thermoplastic resin composition, and an L-shaped end portion or a U-shaped curve of the support. The insertion elastic body is fixed to the portion, and the L-shaped other end portion of the support body or the U-shaped end portion is configured to be fixed to a part of the inner diameter portion of the inner layer tube, Alternatively, the support is composed of a thermoplastic resin composition, preferably a polyamide elastomer.
According to such a feature, the temperature of the NO sensor unit can be detected at the measurement site at the same time, and the three-dimensional area of the support can be effectively used to make the chemical inspection apparatus multifunctional and miniaturized. Become.

In a preferred aspect of the present invention, the insertion elastic body is configured such that an electrode for measuring the potential of the myocardium, applying a potential to the myocardium, or ablating is provided on the outer periphery of the proximal end portion thereof. To do. Preferably, the electrode is provided on an outer periphery of a distal end portion of the outer layer tube, and a lead wire of the electrode is connected to a part of each strand constituting a reinforcing body in a wall body of the outer layer tube. It is the structure. Since it is only necessary to be able to connect the lead wire, the insulated metal good conductor does not have to be embedded in all the constituent wires.
In a preferred aspect of the present invention, the insertion elastic body is configured such that a pressure sensor for measuring the internal pressure of the heart or the internal pressure of the blood vessel is provided at the proximal end portion thereof.
According to this feature, various sensors are integrated and miniaturized so that micro-potential detection at the measurement site, myocardial tissue destruction or modification by electrical stimulation, or internal pressure of the heart or blood vessels can be measured in series. Can be achieved.

To achieve the above object, the present invention provides an outer tube having a hub and a connector connected to one end, a NO sensor that is inserted into the outer tube and detects NO in the liquid at the tip, and a rear end. An inner layer tube provided with each cable connection portion, and a conical insertion elastic body fixed to the tip portion of the NO sensor,
The NO sensor portion protects its outer periphery before contact with the measurement site in the body, and when inserted into the measurement site in the body, by contact between the distal end portion of the outer tube and the proximal end portion of the insertion elastic body. The chemical inspection apparatus is characterized in that the inner layer tube is moved to the distal end side by the connector portion at the measurement site to expose the NO sensor portion.
According to the present invention, when inserted into a measurement site in a body cavity, the outer periphery of the NO sensor is covered, and the NO sensor is exposed by protruding from the outer tube at the measurement site, so that measurement can be performed with high accuracy, and It becomes possible to reduce the damage of the NO sensor. In addition, the chemical inspection apparatus can be reduced in size and simplified.

The present invention is configured as described above and has the effects of the invention as described below.
That is, according to the present invention, the chemical test apparatus can be easily inserted into blood vessels and body cavities, the NO sensor is less damaged and destroyed during insertion or removal, and the inside of blood vessels and body cavities are damaged. Since it is difficult, it is possible to provide a chemical inspection apparatus with high reliability and improved NO detection accuracy.

  In addition, it is possible to organize the connection of the lead ends of each sensor, and since there are no lead wires in the holes of the inner layer and outer layer tubes, etc., there is no miswiring, so a chemical inspection device with high connection reliability can be obtained. Can be provided.

  Further, since one end of the NO sensor can be fixed to the inner layer tube and the other end can be made free, a chemical test apparatus can be provided that is less likely to be damaged or damaged by insertion into the body cavity.

  Moreover, since NO measurement and temperature measurement can be performed at the same time, or NO measurement and stimulation, measurement, ablation, etc. to myocardial tissue can be performed simultaneously, a chemical test apparatus that improves the reliability of the measurement It can be provided, and the chemical inspection apparatus can be miniaturized, simplified, and multifunctional.

Hereinafter, embodiments of the present invention will be described with reference to the drawings.
(First embodiment)
FIG. 1 is a partial cross-sectional side view showing a first embodiment of the chemical testing apparatus of the present invention. The length, thickness, material, and the like are appropriately adjusted. 0 mm, outer diameter 1.4 mm, length about 1100 mm, inner layer tube 10 made of polyamide elastomer, NO sensor 20 fixed to the tip, inner layer tube 10 and NO sensor 20 inner diameter 1.45 mm, The outer layer tube 30 is made of a polyamide elastomer having an outer diameter of 1.60 mm and a length of 950 mm.

For the NO sensor 20, for example, the NO sensor described in Patent Document 2 proposed by the applicant of the present application is used.
FIG. 10 is a diagram showing a specific example of the NO sensor used in the present invention, and is described in Patent Document 2. FIG. The NO sensor 20 includes a sheath tube 110 made of a fluororesin that transmits low molecules such as NO, an electrolyte solution 120 filled therein, a carbon electrode 130 immersed therein, and the sheath tube 110. The sensor is constituted by a comparison electrode 140 provided in close contact with the base side and an insulator 150 that covers the periphery of the comparison electrode 140 so that the comparison electrode 140 is not exposed. The carbon electrode 130, the reference electrode 140, and the insulator 160 are connected to the insulated lead wires 500, 600, and 700, respectively, and the insulated lead wire 700 is for a ground wire.
The signal based on the NO detection value is not limited to the signal transmitted by an electric signal such as a potential difference, and may be transmitted by an optical signal, for example.

  A soft tip 31 composed of a polyamide elastomer having an inner diameter of 1.45 mm, an outer diameter of 1.60 mm, and a length of 3.0 mm and a Shore hardness (D) of 25D to 40D, preferably 35D is fixed to the tip of the outer tube 30. ing. It is preferably ring-shaped, and may have an open / close structure such as a valve. This soft tip facilitates the insertion of the outer layer tube 30 into the body cavity.

  A hub 32 and a Y connector 33 are fixed to the base end side of the outer layer tube 30 with an adhesive. The inner layer tube 10 is inserted into the outer layer tube 30, the hub 32, and the Y connector 33, and the NO sensor 20 attached to the tip of the inner layer tube 10 can be moved forward and backward from the soft tip 31 fixed to the tip of the outer layer tube 30. It has become.

  The electric wire 34 connected to the lead wire housed in the inner hole of the inner layer tube 10 connected to the NO sensor 20 is connected by a connection body 36 at the rear end of the inner layer tube 10, and the other end of the electric wire 34 is connected to the other end of the electric wire 34. A plug connector 35 is attached.

  Each of the inner layer tube 10 and the outer layer tube 30 may have a reinforcing body embedded in the wall thereof, the reinforcing body is constituted by a braided body, and a part thereof is constituted by an enamel coated insulating wire provided with an enamel coated insulating body. It is preferable.

  FIG. 2 is a cross-sectional view of the tip portion of the first embodiment in a state where the NO sensor 20 is protruded. A predetermined number (here, a braided body of fine wires) of lead wires in the inner layer tube 10 connected to the three lead wires 21, 22, 23 of the NO sensor 20 are provided in the inner layer tube wall. 3 pieces) are directly connected to the one constituted by the insulated wire 11 coated with 0.05 mm enamel or polyurethane. The connection between the lead wires 21, 22, 23 of the NO sensor 20 and the insulating wire 11 of the inner layer tube is performed by solder or a conductive adhesive, and the connection between the insulating wire 11 of the inner layer tube and the electric wire 34 (FIG. 1) is also soldered or Conduct with conductive adhesive.

  In the wall of the outer tube, a reinforcing body constituted by a braided body having 16 strokes having two 0.05 mm stainless steel wires may be incorporated. This reinforcing body facilitates insertion into the body cavity.

  In addition, by configuring some of the stainless steel wires constituting the reinforcing body with 0.05 mm insulated wires, the lead wires of the myocardial electrode 60 fixed to the outer tube described later can be directly connected.

  When using a chemical testing device, the NO sensor 20 is inserted into the body without protruding from the outer layer tube, and when the tip reaches the measurement site, the NO sensor 20 is protruded from the outer layer tube by operating outside. I do. After the measurement, the NO sensor 20 is again returned to the outer tube and then extracted outside the body.

(Second and third embodiments)
FIGS. 3A and 3B are cross-sectional views of the tip portions of the second and third embodiments in a state in which the NO sensor 20 is projected, in order to facilitate insertion into the body cavity, An embodiment is shown in which insertion elastic bodies 24a and 24b are provided.

  3A shows a conical insertion elastic body 24a having a base end diameter of 1.65 mm, a tip diameter of 0.80 mm, and a length of 20 mm, which is made of a polyamide elastomer having a Shore hardness of 25 to 40D (preferably 35D). It is.

  The one shown in FIG. 3B is an insertion elastic body 24b composed of a stainless steel wire having a diameter of 0.10 mm and a conical coil body having a base diameter of 1.65 mm, a tip diameter of 0.80 mm, and a length of 15 mm. An insert base 25 made of polyamide elastomer having a diameter of 1.65 mm and a length of 5.0 mm is fixed to the base end side.

  The sticking of the insertion elastic body to the tip of the NO sensor is fixed by an adhesive, but when the NO sensor portion is inserted into or removed from the body cavity, the problem that the insertion elastic body is removed from the NO sensor portion is eliminated. For this purpose, a hole having an outer diameter of the NO sensor may be formed in the center of the base end portion of the insertion elastic body, and the tip of the NO sensor may be inserted into the hole, and an adhesive may be applied and fixed.

  By fixing the insertion elastic body, it becomes easier to insert the NO sensor portion into the body cavity, and the distal end portion of the outer tube can be brought into contact with the proximal end portion of the insertion elastic body. Since it can be sealed and protected, the NO sensor can be prevented from being destroyed or broken due to insertion or removal of the NO sensor into the body cavity.

(Fourth embodiment)
FIG. 4 is a cross-sectional view of the distal end portion of the fourth embodiment in a state where the NO sensor 20 is projected, and shows another attachment mechanism of the insertion elastic body attached to the NO sensor distal end portion. A support body 40 made of a highly elastic nickel-titanium alloy material having a width of 0.30 mm, a thickness of 0.15 mm, and a length of 25 mm and having a substantially L-shaped fixing portion 41 at one end is provided. The L-shaped fixing portion 41 is fixed by heat fusion on the proximal end side of the insertion elastic body 24c molded in advance, and the fixing portion 42 at the other end of the support body 40 extends from the tip of the inner hole of the inner tube 10. Insert up to 10mm, and fix with adhesive along the inner hole wall.
When the adhesion between the support 40, the insertion elastic body 24c, and the inner layer tube 10 is further strengthened, it is further strengthened by configuring both ends of the support 40 into a semi-annular body having a radius of 1.0 mm.

  An inner hole 26 having a diameter of 0.75 mm and a depth of 4.0 mm is formed in the central portion of the base end portion of the insertion elastic body 24c, the tip portion of the NO sensor is accommodated at 3.0 mm, and the NO sensor is exposed at 10.0 mm. ing. With this configuration, the NO sensor 20 is not fixed to the insertion elastic body 24c and becomes free, so that destruction during insertion or removal from the body cavity is eliminated.

  The support 40 may be made of a plastic resin such as a polyamide elastomer. Moreover, you may apply multiple support bodies 40 as needed.

  FIG. 5A shows a temperature sensor 50 provided on the support body 40, and FIG. 5B shows a BB ′ cross-sectional view in FIG. 5A, and the temperature sensor 50 covers one surface of the support body 40 with an insulator 45. A temperature sensor 50 of a T-type thermocouple composed of a copper wire 43 having a diameter of 0.05 mm and a constantan wire 44 having a diameter of 0.05 mm is provided at the substantially central portion of the support body 40 to insulate the surface. The body 45 is covered and configured.

  FIG. 5C is a cross-sectional view taken along the line CC ′ in FIG. 5A of another embodiment. When the support body 40 is made of a polyamide elastomer resin, the inner wall tube 10 is thermally bonded to the wall body. The temperature sensor 50 is embedded in an insulator made of polyamide elastomer, and the lead wire of the temperature sensor 50 is connected to the lead hole provided in the inner hole of the inner tube 10 or the wall body by solder or conductive adhesive. The

  The temperature of the insertion site in the body cavity is monitored by the temperature sensor 50, and the correlation between the temperature in the body cavity and NO can be grasped. In addition, if this temperature sensor 50 is provided with another detector, it can measure a blood flow rate, a cardiac output, etc. simultaneously.

(Fifth embodiment)
FIG. 6A is a cross-sectional view of the distal end portion of the fifth embodiment in a state in which the NO sensor 20 is projected, and shows an attachment mechanism of the electrode 60 for detecting a potential in the insertion elastic body 24d. A lead made of a platinum tube having an inner diameter of 1.50 mm, an outer diameter of 1.65 mm, and a length of 1.00 mm, and an insulating wire coated with 0.05 mm diameter of enamel or polyurethane is provided at the base end of the insertion elastic body 24d. Two electrodes 60 connected to the wire 61 are provided on the outer periphery of the insertion elastic body 24d with an interval of about 2.0 mm. The electrode 60 measures the potential of the myocardium or applies a potential to the myocardium. The electrode 60 is fixed to the proximal end portion 27 of the insertion elastic body 24d by thermal fusion, and the lead wire 61 is connected to the support 40 (here Then, along the surface of the support body having a substantially U-shaped adhering portion, it is connected to a part of the insulating wire constituting the inner tube 10 lumen or the reinforcing body in the wall and connected to the detection device.
As shown in FIG. 6B, the support body 40 has a substantially U shape, one end of which is fixed to the front end of the inner layer tube 10, and the U-shaped portion is fixed to the rear end of the insertion elastic body 24d.
By providing the electrode 60, it is possible to apply a potential of the body cavity is measured or potential, while measuring or applying a potential, the temperature is measured, it is possible to measure the NO. Further, by making the support body 40 substantially U-shaped, adhesion to the inner tube or the insertion elastic body is strengthened.

(Sixth embodiment)
FIG. 7 is a cross-sectional view of the tip portion of the sixth embodiment in a state where the NO sensor 20 is protruded. This figure relates to an insertion elastic body 24e having an insertion body pedestal 25e in which the insertion elastic body 24e is constituted by a conical coil body made of stainless steel wire or the like, and its base is made of a plastic resin such as polyamide elastomer. In addition, the electrode 60 is integrated with the insert base 25e by heat fusion or application of an adhesive.

(Seventh embodiment)
FIG. 8 is a cross-sectional view of the distal end portion according to the seventh embodiment of the present invention, in which the electrode 60 described above is provided at a predetermined distal end portion of the outer layer tube 30. Two electrodes are provided on the outer periphery of the outer layer tube 30 at a predetermined distance from the tip of the outer layer tube 30 at an interval of about 2.0 mm. Connected and connected to the detector. According to this configuration, since the electrode 60 is provided on the outer periphery of the outer layer tube, integration can be achieved.

(Eighth embodiment)
FIG. 9 is a cross-sectional view of the distal end portion of the eighth embodiment in a state where the NO sensor 20 is projected, and a pressure sensor 70 that measures the internal pressure in the body cavity is provided on the outer periphery of the proximal end portion 27 of the insertion elastic body 24d. This is provided in place of the electrode 60 described above. The pressure sensor 70 is configured by connecting a lead wire 71 having a diameter of 0.05 mm to a sensing unit 72 having a diameter of 1.65 mm and a length of 3.0 mm. Further, the pressure sensor 70 employs a semiconductor chip pressure transducer and is fixed to the insertion elastic body base end portion 27 by an embedded adhesive. The lead end of the lead wire 71 of the pressure sensor 70 is constituted by a lead wire circuit body of the support body 40, a lead wire in the inner hole of the inner tube 10 or an insulating wire constituting a reinforcement provided in the inner tube wall. Connected to the lead wire, connected to the wire 34 and connected to the detector. By providing this pressure sensor 70 on the outer periphery of the proximal end portion 27 of the insertion elastic body 24d, the body cavity pressure can be measured, and the temperature can be measured and NO can be measured while measuring the internal pressure. Become.

FIG. 1 is a partial cross-sectional side view showing a first embodiment of a chemical testing apparatus of the present invention. FIG. 2 is a cross-sectional view of the tip portion of the first embodiment in a state where the NO sensor 20 is protruded. 3A and 3B are cross-sectional views of the tip portions of the second and third embodiments with the NO sensor 20 protruding. FIG. 4 is a cross-sectional view of the tip portion of the fourth embodiment in a state in which the NO sensor 20 is protruded. FIG. 5A is a cross-sectional view showing the temperature sensor 50 provided on the support 40. FIG. 5B is a cross-sectional view taken along the line BB ′ in FIG. 5A. FIG. 5C shows a CC ′ cross-sectional view in FIG. 5A. FIG. 6A is a cross-sectional view of the distal end portion of the fifth embodiment in a state where the NO sensor 20 is protruded. FIG. 6B is a perspective view of a fifth embodiment in which the insertion elastic body is not shown. FIG. 7 is a cross-sectional view of the tip portion of the sixth embodiment in a state where the NO sensor 20 is protruded. FIG. 8 is a cross-sectional view of the distal end portion in the seventh embodiment of the present invention. FIG. 9 is a cross-sectional view of the tip portion of the ninth embodiment in a state where the NO sensor 20 is protruded. FIG. 10 is a diagram showing a specific example of the NO sensor used in the present invention. FIG. 11 is a cross-sectional view showing a conventional chemical inspection apparatus.

Explanation of symbols

10: Inner layer tube 11: Insulated wire 20: NO sensor 21, 22, 23: Lead wires 24a, 24b, 24c, 24d, 24e: Insertion elastic body 25, 25e: Insert body base 26: Inner hole 27: Insertion elastic body base End part 30: Outer layer tube 31: Soft tip 32: Hub 33: Y connector 34: Electric wire 35: Plug connector 36: Connection body 40: Support body 41: Adhering part 42: Adhering part 43: Copper wire 44: Constantan wire 45 : Insulator 50: Temperature sensor 60: Electrode 61: Lead wire 70: Pressure sensor 71: Lead wire 72: Sensor 81: Flexible tube 82: Pressure sensor 83: Guide wire 84: Optical fiber 85: Sleeve 86: Metal tube 87: tip portion 88: helical winding 110: outer tube 120: electrolyte 130: carbon electrode 140: comparative electrode 15 0,160: Insulator 500,600,700: Insulated lead wire

Claims (13)

An inner tube having flexibility;
A nitric oxide sensor (hereinafter referred to as NO sensor) for detecting nitric oxide (hereinafter referred to as NO) in the liquid attached to the tip of the inner layer tube;
It is composed of a flexible outer layer tube covering the outer periphery of the NO sensor and the inner layer tube,
The outer circumference of the NO sensor is covered with the outer layer tube when inserted into a measurement site in the body, and the inner layer tube end is moved and exposed from the outer layer tube at the measurement site. Chemical inspection equipment characterized by   The inner layer tube has a reinforcing body in a wall thereof, and a lead wire of the NO sensor is configured to be connected to a part of each strand constituting the reinforcing body. 1. The chemical inspection apparatus according to 1.   3. The outer-layer tube has a reinforcing body in a wall thereof, and a part of each of the strands constituting the reinforcing body is constituted by an insulated metal good conductor. The chemical testing device described.   The tip of the outer layer tube is fixed to the tip thereof, and the tip is made of a thermoplastic composition and is flexible. A chemical inspection apparatus according to any one of the claims.   The NO sensor is provided with an insertion elastic body at its distal end, and the insertion elastic body has an outer diameter that is the same as or slightly larger than the outer diameter of the outer tube. However, it has a conical shape whose outer diameter tapers from the base end portion toward the tip end portion and has flexibility, and when inserted into a measurement site in the body, the base of the insertion elastic body The structure according to any one of claims 1 to 4, wherein the NO sensor can be protected by contacting an end portion with a tip portion of the outer tube or a tip portion of the tip. The chemical inspection apparatus according to the item.   The NO sensor is provided with an insertion elastic body at a distal end portion thereof, and the insertion elastic body is fixed to the other end of a support body having one end fixed to the inner diameter portion of the inner layer tube. The proximal end is provided with an insertion portion into which the distal end of the NO sensor is inserted, and a part of the distal end of the NO sensor is inserted, and when inserted into a measurement site in the body, the insertion elastic body The structure according to any one of claims 1 to 5, wherein the NO sensor can be protected by contacting a proximal end portion with a distal end portion of the outer layer tube or a distal end portion of the distal end tip. The chemical inspection apparatus according to the item.   7. The chemistry according to claim 5, wherein the insertion elastic body includes a distal end portion formed of a metal elastic body in a coiled conical shape and an insertion body base formed of an elastic plastic material. Inspection device.   The support is integrally provided with a temperature sensor for measuring the temperature in the body cavity at a substantially intermediate portion thereof, and the lead wire connected to the temperature sensor constitutes a reinforcement in the wall of the inner tube. The chemical inspection apparatus according to claim 6 or 7, wherein the chemical inspection apparatus is connected to a part of the strand.   The support is configured to be substantially L-shaped or U-shaped using a highly elastic metal material or a thermoplastic resin composition, and the insertion is inserted into the L-shaped end or U-shaped curved portion of the support. The elastic body is fixed, and a part of the inner diameter portion of the inner layer tube is fixed to the other end of the L-shape or the U-shape of the support. The chemical inspection apparatus according to claim 8. It said insert elastic body, at its proximal end outer peripheral, measuring the potential of the heart muscle, applying a potential to the myocardium, or claims 5 to electrodes is characterized in that it is configured provided for ablation The chemical inspection apparatus according to claim 9. Preconfiguration Symbol electrodes, the provided on the outer periphery of the distal end portion of the outer tube, the lead before Symbol electrodes which are connected to a part of the wires constituting the reinforcement in the wall of said outer tube The chemical inspection apparatus according to claim 10, wherein:   The said insertion elastic body is provided with the pressure sensor for measuring the internal pressure of the heart or the internal pressure of the blood vessel in the base end part, The structure of any one of Claim 5 thru | or 11 characterized by the above-mentioned. The chemical inspection device described in 1. An outer tube with a hub and connector connected to one end;
An inner layer tube that is inserted into the outer layer tube, provided with a NO sensor that detects NO in the liquid at the tip, and provided with each cable connection portion at the rear end;
A conical insertion elastic body fixed to the tip of the NO sensor,
The NO sensor portion protects its outer periphery before contact with the measurement site in the body, and when inserted into the measurement site in the body, by contact between the distal end portion of the outer tube and the proximal end portion of the insertion elastic body. The chemical test apparatus is configured to expose the NO sensor portion by moving the inner tube to the distal end side by the connector portion at a measurement site.

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