JP4139844B2 - 電気式搬送装置用の複層式流量制御膜体 - Google Patents
電気式搬送装置用の複層式流量制御膜体 Download PDFInfo
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- JP4139844B2 JP4139844B2 JP2007161218A JP2007161218A JP4139844B2 JP 4139844 B2 JP4139844 B2 JP 4139844B2 JP 2007161218 A JP2007161218 A JP 2007161218A JP 2007161218 A JP2007161218 A JP 2007161218A JP 4139844 B2 JP4139844 B2 JP 4139844B2
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- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
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- A—HUMAN NECESSITIES
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- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
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Description
本発明の一実施例においては、電気式搬送装置に適用した流量制御用の膜体構造に関している。この膜体構造は、電気式搬送装置に組み込まれるようになっており、薬剤および/または治療媒体の搬送量の精度および正確性を向上する。この精度および正確性の向上を図るために、膜体構造に高多孔性層および低多孔性層とを具備させる。実施例では、高多孔性層を投与貯留部と体表面に隣接する低多孔性層との間に設けている。
重合体の母体は、薬剤媒体あるいは電解質(および他の組成成分)を不活性重合体に配合することにより形成された重合性母体構造からなる。投与貯留部16は、搬送用の薬剤媒体を含み、対抗貯留部18は、水溶性生体適合塩といった電解質を含む。貯留部の組成物は、重量で母体の約25〜90%の範囲内にあるのが望ましい。疎水性重合体は、薬剤媒体の搬送を促すため透孔(あるいは微小細孔)を開放状態に維持する性質を有する重合体構造を含んでもよい。
Claims (13)
- 体表面を介して治療媒体を搬送する電気式搬送装置において、
電源と、
投与電極と、治療媒体を収容した投与貯留部と、第1および第2の多孔質膜体を有する投与膜体構造とを備えた投与電極部と、
対抗電極と、対抗貯留部と、対抗膜体構造とを備えた対抗電極部と、
前記電源から前記投与電極および対抗電極への電力の供給を制御する制御部とを有し、
第1の多孔質膜体は、第2の多孔質膜体と同じ平均透孔寸法を有し、第2の多孔質膜体より大きい多孔度を有することにより、第2の多孔質膜体の閉塞を防止し、投与電極部を介した治療媒体の搬送速度を維持することを特徴とする電気式搬送装置。 - 第1の多孔質膜体は、投与貯留部と第2の多孔質膜体の間に配設することにより、投与貯留部内の汚染物に起因する第2の多孔質膜体の閉塞を防止することを特徴とする請求項1に記載の電気式搬送装置。
- 第2の多孔質膜体は、投与貯留部と第1の多孔質膜体の間に配設することにより、体表面上の汚染物に起因する第2の多孔質膜体の閉塞を防止することを特徴とする請求項1に記載の電気式搬送装置。
- 投与膜体構造は、第1の多孔質膜体と協働して第2の多孔質膜体を挟持する第3の多孔質膜体をさらに有し、
第3の多孔質膜体は、第2の多孔質膜体より大きい多孔度を有することにより、投与貯留部内の汚染物および体表面上の汚染物に起因する第2の多孔質膜体の閉塞を防止することを特徴とする請求項1に記載の電気式搬送装置。 - 第2の多孔質膜体は、第1および第3の多孔質膜体の間に封止されることを特徴とする請求項4に記載の電気式搬送装置。
- 第1の多孔質膜体は10%以上の多孔度を有し、
第2の多孔質膜体は1.0%以下の多孔度を有することを特徴とする請求項1に記載の電気式搬送装置。 - 第3の多孔質膜体は10%以上の多孔度を有することを特徴とする請求項4に記載の電気式搬送装置。
- 第1の多孔質膜体は20%以上の多孔度を有し、
第2の多孔質膜体は0.1%以下の多孔度を有することを特徴とする請求項1に記載の電気式搬送装置。 - 第3の多孔質膜体は20%以上の多孔度を有することを特徴とする請求項8に記載の電気式搬送装置。
- 投与電極部と対抗電極部の間を電気的に絶縁するために設けられた絶縁手段と、
電気式搬送装置を支持する裏壁層とを備え、
対抗貯留部は、重合母体を収容し、
前記電源は、リチューム電池あるいは薄膜電池であり、
前記制御部は、マイクロプロセッサであり、
前記対抗貯留部および/あるいは投与貯留部は、染料、顔料、充填物、流動学的媒体、アルカリ金属塩、アルカリ土類金属塩およびこれらの組合せからなる群から選択された材料を用いて形成されており、
前記投与電極は、陽極で銀により形成され、
前記対抗電極は、陰極で塩化銀により形成されていることを特徴とする請求項1に記載の電気式搬送装置。 - 前記第1の多孔質膜体は、実質的に筒状の透孔を有し、治療媒体の分子より大きく、1mmより小さい平均透孔寸法を有することを特徴とする請求項1に記載の電気式搬送装置。
- 前記第1の平均透孔寸法は、0.01〜200ミクロンであることを特徴とする請求項11に記載の電気式搬送装置。
- 前記第2の平均透孔寸法は、1.0ミクロンであり、
前記第1および第3の平均透孔寸法は、5.0ミクロンであることを特徴とする請求項4に記載の電気式搬送装置。
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DE69807746D1 (de) | 2002-10-10 |
CA2315228C (en) | 2007-09-18 |
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WO1999030774A1 (en) | 1999-06-24 |
EP1039949A1 (en) | 2000-10-04 |
ES2181315T3 (es) | 2003-02-16 |
DE69807746T2 (de) | 2003-01-02 |
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