JP4119649B2 - 単一真空源を有する高スループットシステムにおける稀釈 - Google Patents

単一真空源を有する高スループットシステムにおける稀釈 Download PDF

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Publication number
JP4119649B2
JP4119649B2 JP2001519171A JP2001519171A JP4119649B2 JP 4119649 B2 JP4119649 B2 JP 4119649B2 JP 2001519171 A JP2001519171 A JP 2001519171A JP 2001519171 A JP2001519171 A JP 2001519171A JP 4119649 B2 JP4119649 B2 JP 4119649B2
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Japan
Prior art keywords
fluid
main channel
channel
flow reduction
channels
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Expired - Fee Related
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JP2001519171A
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English (en)
Japanese (ja)
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JP2003507737A (ja
JP2003507737A5 (https=
Inventor
アン・アール・コッフ−シル
スティーヴン・エー・サンドバーグ
アンドレア・ダブリュー・チャウ
クラウディア・エル・ポグリッシュ
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Caliper Liff Sciences Inc
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Caliper Liff Sciences Inc
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
JP2001519171A 1999-08-25 2000-08-23 単一真空源を有する高スループットシステムにおける稀釈 Expired - Fee Related JP4119649B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US15067099P 1999-08-25 1999-08-25
US60/150,670 1999-08-25
US15901499P 1999-10-12 1999-10-12
US60/159,014 1999-10-12
US20013900P 2000-04-27 2000-04-27
US60/200,139 2000-04-27
PCT/US2000/023220 WO2001014865A1 (en) 1999-08-25 2000-08-23 Dilutions in high throughput systems with a single vacuum source

Publications (3)

Publication Number Publication Date
JP2003507737A JP2003507737A (ja) 2003-02-25
JP2003507737A5 JP2003507737A5 (https=) 2006-01-05
JP4119649B2 true JP4119649B2 (ja) 2008-07-16

Family

ID=27387014

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001519171A Expired - Fee Related JP4119649B2 (ja) 1999-08-25 2000-08-23 単一真空源を有する高スループットシステムにおける稀釈

Country Status (5)

Country Link
EP (1) EP1208370A4 (https=)
JP (1) JP4119649B2 (https=)
AU (1) AU6932300A (https=)
CA (1) CA2380897A1 (https=)
WO (1) WO2001014865A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013501936A (ja) * 2009-08-12 2013-01-17 カリパー・ライフ・サイエンシズ・インク． 断片化した試料の分別のための挟持チャンネル

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7037416B2 (en) 2000-01-14 2006-05-02 Caliper Life Sciences, Inc. Method for monitoring flow rate using fluorescent markers
US20090118139A1 (en) 2000-11-07 2009-05-07 Caliper Life Sciences, Inc. Microfluidic method and system for enzyme inhibition activity screening
US7723099B2 (en) * 2003-09-10 2010-05-25 Abbott Point Of Care Inc. Immunoassay device with immuno-reference electrode
US7740806B2 (en) * 2006-02-28 2010-06-22 International Business Machines Corporation Ceramic microarray spotting device for bioassay printing
ES2649559T3 (es) * 2009-11-23 2018-01-12 Cyvek, Inc. Método y aparato para realizar ensayos
WO2013134741A2 (en) 2012-03-08 2013-09-12 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
US9500645B2 (en) 2009-11-23 2016-11-22 Cyvek, Inc. Micro-tube particles for microfluidic assays and methods of manufacture
US9855735B2 (en) 2009-11-23 2018-01-02 Cyvek, Inc. Portable microfluidic assay devices and methods of manufacture and use
US9651568B2 (en) 2009-11-23 2017-05-16 Cyvek, Inc. Methods and systems for epi-fluorescent monitoring and scanning for microfluidic assays
US9700889B2 (en) 2009-11-23 2017-07-11 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
US10065403B2 (en) 2009-11-23 2018-09-04 Cyvek, Inc. Microfluidic assay assemblies and methods of manufacture
US9759718B2 (en) 2009-11-23 2017-09-12 Cyvek, Inc. PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use
US9421540B2 (en) 2010-10-28 2016-08-23 International Business Machines Corporation Microfluidic device with auxiliary and bypass channels
WO2012129455A2 (en) 2011-03-22 2012-09-27 Cyvek, Inc Microfluidic devices and methods of manufacture and use
JP6449266B2 (ja) 2013-06-21 2019-01-09 バイオ−ラッド・ラボラトリーズ・インコーポレーテッド 流体ピックアップを備えるマイクロ流体システム
KR102587637B1 (ko) 2014-12-12 2023-10-10 옵코 다이어그노스틱스, 엘엘씨 성형에 의해 제조되는 유체 시스템을 비롯한, 항온 처리 채널을 포함하는 유체 시스템
US10048190B2 (en) 2015-01-21 2018-08-14 Sbt Instruments Aps Microfluidic particle analysis device
US10228367B2 (en) 2015-12-01 2019-03-12 ProteinSimple Segmented multi-use automated assay cartridge
WO2018148693A1 (en) 2017-02-13 2018-08-16 Bio-Rad Laboratories, Inc. System, method, and device for forming an array of emulsions
EP3791956B1 (en) * 2019-09-11 2023-04-12 CSEM Centre Suisse D'electronique Et De Microtechnique SA Microfluidic sensing device and cartridge, and corresponding methods

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5779868A (en) * 1996-06-28 1998-07-14 Caliper Technologies Corporation Electropipettor and compensation means for electrophoretic bias
US5869004A (en) * 1997-06-09 1999-02-09 Caliper Technologies Corp. Methods and apparatus for in situ concentration and/or dilution of materials in microfluidic systems

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013501936A (ja) * 2009-08-12 2013-01-17 カリパー・ライフ・サイエンシズ・インク． 断片化した試料の分別のための挟持チャンネル

Also Published As

Publication number Publication date
EP1208370A1 (en) 2002-05-29
EP1208370A4 (en) 2006-05-31
JP2003507737A (ja) 2003-02-25
CA2380897A1 (en) 2001-03-01
AU6932300A (en) 2001-03-19
WO2001014865A1 (en) 2001-03-01

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