JP4105103B2 - Composition for external use - Google Patents

Description

The present invention relates to a composition for external use such as a cosmetic, a quasi-drug or a skin external preparation containing a hair growth inhibitor such as a hair growth inhibitor made of a specific herbal medicine or an extract thereof.

  In recent years, body hairs such as limbs and chest tend to be less or less preferred for reasons of aesthetic appearance, and various body hair removal methods have been developed and used. Specific examples include a mechanical removal method using a shaver, a hair remover, etc., a method of removing body hair from the hair root using a hair removal agent, a method of removing body hair by its chemical action using a hair removal agent, and the like. . However, since these hair removal methods must remove the hair again after a lapse of a certain period of time, the skin hair is repeatedly stimulated and burdensome.

Therefore, there is a method of delaying hair growth and reducing the frequency of hair removal treatment by using an external composition containing a substance having an effect of suppressing hair growth. For example, it contains plant extracts (Ogon, assembly, clove, aloe, hops, licorice, salamander, carrot, carrot, lacanmaki, machazul, henna leaves, sicon, yokuinin, rice germ) that suppresses active androgen. It is known that by using a hair growth inhibitor, hair growth of body hair can be suppressed, and body hair can be reduced more effectively (Patent Document 1). Applying a topical active composition containing a compound derived from a legume, solanaceous, gramineous, or cucurbitaceae plant with serine protease inhibitory activity to affect changes in hair growth, hair follicle and hair pigmentation (Patent Document 2). It is known that a hair growth / hair growth inhibitory effect can be obtained by using a cosmetic composition containing a plant extract that suppresses hair growth (Ichihatsu, Ononis, Soybean, Kudzu, Nioiiris, Hagigi, Hitosumidae, Hop). (Patent Document 3). A specific herbal medicine or extract thereof that acts directly on hair matrix cells and dermal papilla cells and exhibits an excellent hair growth inhibitory effect (Dokudami, Awaku, Rice bran, Mulberry, Auren, Thyme, Tonin, Ichiyakusuka, Tokinsenka, Novara , Melissa) and other external compositions such as cosmetics are known (Patent Document 4). Plant extract with anti-androgenic action (Arnica, Aloe, Auren, Panax ginseng, Hypericum, Kina, Mulberry, Salamander, Elephant, Sage, Assembly, Soybean, Thyme, Clove, Button, Hop, Yokuinin, Logwood, Rosemary ) Or an essential oil and a hair growth inhibitor containing a plant extract having a skin astringent action or a capillary contraction action is known to exhibit a hair growth inhibitory effect (Patent Document 5). Cypress and plant extract with anti-androgenic action (Arnica, Aloe, Auren, Panax ginseng, Hypericum, Kina, Mulberry, Salamander, Giant, Sage, Assembly, Soy, Thyme, Clove, Button, Hop, Yokuinin, Logwood , Rosemary) or essential oil, and a plant extract having skin astringent action or capillary contraction action, and further, a hair growth inhibitor containing a natural or chemically modified phospholipid is known to have a hair growth inhibitory effect. (Patent Document 6).

JP 2001-28809 A JP 2001-72555 A JP-A-11-322548 JP 2003-306415 A JP 2001-316234 A JP 2003-137747 A

  However, the effect of suppressing hair growth in these external compositions has not been sufficient yet. In addition, since hair removal and hair removal treatment give chemical and physical stimulation to the skin, it may cause skin roughness and inflammation on the skin, and may cause a skin condition in which the effect of suppressing hair growth is difficult to exert. An object of the present invention is to provide a safe composition for external use that has a high hair growth inhibitory effect on hands, feet, wrinkles and the like and that does not cause irritation or inflammation on the skin.

The present invention relates to allantoin, soybean, scented squirrel, cypress, oxon, assembly, clove, aloe, hops, licorice, salamander, carrot, licorice, achazal, henna, sicon, yokuinin, ichihatsu, onis, kuzu, tsutsuhienida At least one herbal medicine selected from, Dokudami, Awaku, Mulberry, Auren, Thyme, Tonin, Ichiyakuso, Ginseng, Novara, Melissa, Arnica, Cuckon, Hypericum, Kina, Sage, Button, Logwood or Rosemary The composition for external use containing the hair growth inhibitor made from a thing.
Also, allantoin, soybean, scented swordfish, giant eel, dragonfly, clove, clove, aloe, hops, licorice, salamander, dragonfly, carrot, licorice, witch moth, henna, sicon, yokuinin, ichihatsu, onis, kuzu, scabbard, fern And at least one herbal medicine selected from the group consisting of: Oat, Mulberry, Auren, Thyme, Tonin, Ichiyakusou, Tokinsenka, Novara, Melissa, Arnica, Cakkon, Hypericum, Kina, Sage, Button, Logwood or Rosemary Is a composition for external use for suppressing hair growth.

  The composition for external use of the present invention has an excellent ability to suppress growth of hair and has a high effect of improving skin roughness on the skin. It is possible to provide an external composition that can further reduce the burden of the hair removal treatment.

  Allantoin in the present invention is a known compound. Moreover, allantoin derivatives, such as allantoin chlorohydroxyaluminum and allantoin dihydroxyaluminum, can also be used. Although it does not prescribe | regulate especially as a compounding quantity to an external composition, Usually, 0.001 to 5 weight% can be mix | blended, Preferably it is 0.01 to 1 weight%, Most preferably, it is 0.01 to 0.5% by weight.

The composition for external use of the present invention includes soybeans , scented squirrels (also known as white squirrels) , Japanese cedar , Japanese cypress , sea bream, clove, clove, aloe, hops, licorice, salamander, carrots, carrots, rakanmaki, macaques, henna, sicons, yokuinin. , Ichihatsu, Ononis, Kudzu, Hitosuba Enishi, Dokdami, Owaku, Mulberry, Ouren, Thyme, Tonin, Ichiyaku, Ginseng, Novara, Melissa, Arnica, Cuckoo, Hypericum, Kina, Sage, Button, Logwood or Rosemary Containing at least one herbal medicine or an extract thereof. These specific crude drugs or extracts thereof are used as hair growth inhibitors. Of these, herbal medicines or extracts thereof containing flavosterone (or isoflavones) such as soybean, scented oil, cypress, and cuckoo, or dokudami, aloe, carrot, licorice and rosemary are preferred.

  These herbal medicines or extracts are preferably contained in a composition for external use in combination of two or more, for example, a combination of barley, soybean and scented squirrel, a combination of sardine and parenthesis, a combination of sardine and soy, Examples include combinations, kacon, scented sardines, and soy beans, scallops and carrots, scallops, scented licorice, and licorices, licorice, aloe and scented squirrels.

  Soybean, squirrel, sorghum, cormorant, clove, clove, aloe, hop, licorice, salamander, elephant, carrot, rakanmaki, hamachuru, henna, sicon, yokuinin, ichihatsu, onionis, kudzu, hitobetsuida, dokudami , Buckwheat, mulberry, auren, thyme, tonin, Ichiyakusu, red snapper, Novara, Melissa, Arnica, Cakkon, Hypericum, Kina, Sage, Button, Logwood or Rosemary herbal medicine or its extract Various parts (whole, flowers, flower heads, flower buds, flower spikes, leaves, branches, branches and leaves, rhizomes, root barks, roots, fruits, pericarps, legumes, seeds, etc.) as they are or dried, ground, ground It is what was post-exploded or extracted with an extraction solvent.

  As an extraction solvent in the case of an extract, water (including hot water), alcohols such as methanol, ethanol, isopropanol, ethylene glycol and glycerin, esters such as ethyl acetate, ketones such as acetone and methyl ethyl ketone, acetonitrile Nitriles such as diethyl ether and tetrahydrofuran, saturated hydrocarbons such as pentane, hexane, cyclopentane and cyclohexane, aromatic hydrocarbons such as toluene, halogenated hydrocarbons such as dichloromethane and chloroform, etc. Organic solvents such as dimethylformamide and dimethyl sulfoxide (all of which may be water-containing) can be appropriately used, and one or two arbitrary mixed liquids may be used. Of these solvents, water, ethanol, or a mixed solution thereof is preferable from the viewpoint of safety.

  Each specific herbal medicine or an extract thereof can be produced from the whole plant or a necessary part of the plant by the above-described method, a known or conventional method, and a commercially available product can also be used.

  In the present invention, the amount of the specific herbal medicine or its extract added to the external composition is not particularly specified, but the total amount of the specific herbal medicine or its extract is usually 0.001 wt% or more and 20 wt%. It can mix | blend below, Preferably it is 0.001 to 10 weight%, Especially preferably, it is 0.005 to 5 weight%.

  Furthermore, other anti-inflammatory agents can be used in combination with the external composition of the present invention. Examples of such other anti-inflammatory agents include glycyrrhizic acid derivatives such as glycyrrhizic acid, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, glycyrrhetinic acid or derivatives thereof, and salicylic acid derivatives such as methyl salicylate or glycol salicylate. Of these, glycyrrhizic acid or a derivative thereof, or glycyrrhetinic acid or a derivative thereof is preferable. Although it does not prescribe | regulate especially as a compounding quantity to the composition for external use of another anti-inflammatory agent, Usually, 0.001 to 20 weight% can be mix | blended, Preferably 0.01 to 10 weight%, especially Preferably it is 0.01 to 5 weight%.

Furthermore, this invention can improve an effect by further containing at least one compound selected from a vinyl polymer, a cellulose polymer, a liquid oil, or a fatty acid dextrin, which is preferable.
The vinyl polymer and the cellulose polymer are not particularly limited as long as they are pharmaceutically acceptable. Examples of the vinyl polymer include carbogood (trade name) manufactured by BFGoodrich and sinterene (trade name) manufactured by 3VSIGMA. Carboxy vinyl polymers such as Noveon's Carbopol AQUA SF-1 (trade name), acrylic acid copolymers such as BFGoodrich's PEMULEN (trade name), polyacrylic acid, polyvinyl alcohol And polyvinylpyrrolidone. Examples of the cellulose polymer include methyl cellulose, hydroxyethyl cellulose, hydroxyethyl methyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, methyl hydroxypropyl cellulose, sodium carboxymethyl cellulose, and the like. They can also be used as pharmaceutically acceptable salts.

  The amount of the vinyl polymer and the cellulose polymer that can be blended in the externally applied composition of the present invention is not particularly limited as long as the effects of the present invention are exerted, but is usually 0.001 part by weight or more per 100 parts by weight of the externally applied composition, The upper limit is usually 5 parts by weight or less, preferably 3 parts by weight or less, and particularly preferably 2 parts by weight or less.

  The liquid oil is not particularly limited as long as it is an oil that is liquid at 25 ° C. and is pharmaceutically acceptable. However, it is preferable to use a light oil with little oiliness and a light feel. Specifically, di-2-heptylundecyl adipate, isononyl isononanoate, isotridecyl isononanoate, isodecyl isononanoate, cetyl isooctanoate, isostearyl isostearate, cetyl octanoate, oleyl oleate, ethyl oleate, oleic acid Decyl, propylene glycol diisononanoate, neopentylene glycol di-2-ethylhexanoate, propylene glycol dicaprylate, ethylene glycol diisononanoate, neopentyl glycol dicaprate, isostearyl myristate, isopropyl myristate, isocetyl myristate, myristic acid Octyldodecyl, isopropyl palmitate, isostearyl palmitate, 2-hexyldecyl palmitate, octyl palmitate, lactate Still, cetyl lactate, octyl lactate, diisostearyl malate, cholesteryl 12-hydroxystearylate, pentane erythritol tetraoctanoate, polyglyceryl tetraisostearate, pentaerythritol tetra-2-ethylhexanoate, ethyl stearate, butyl stearate , Ethyl linoleate, isopropyl linoleate, N-lauroyl-L-glutamic acid-2-octyldodecyl ester, isopropyl isostearate, neopentyl glycol dicaprate, glyceryl tri (caprylate / caprate), glyceryl tri-2-ethylhexanoate, Trioctyl trioctanoate, glyceryl trioctanoate, (2-hexyldecanoic acid / sebacic acid) diglyceryl oligoester, polypropylene succinate Cole oligoesters, polyglyceryl triisostearate, polyglyceryl diisostearate, jojoba oil, macadamia nut oil, meadow foam oil, methylpolysiloxane, decamethylcyclopentasiloxane, methylhydrogenpolysiloxane, methylphenylpolysiloxane, etc., preferably Isononyl isononanoate, cetyl isooctanoate, isostearyl isostearate, propylene glycol dicaprylate, isostearyl myristate, isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, isostearyl palmitate, octyl palmitate, octyl lactate, tetraoctane Acid pentane erythlit, tetra-2-ethylhexanoic acid pentaerythlit, N-lauro Ile-L-glutamic acid-2-octyldodecyl ester, tri (capryl / capric acid) glyceryl, tri-2-ethylhexanoic acid glyceryl, trioctanoic acid trimethylolpropane, (2-hexyldecanoic acid / sebacic acid) diglyceryl oligoester, tri Polyglyceryl isostearate, jojoba oil, macadamia nut oil, meadow foam oil, methylpolysiloxane, decamethylcyclopentasiloxane, methylhydrogenpolysiloxane, and methylphenylpolysiloxane.

  The amount of liquid oil that can be blended in the composition for external use of the present invention is not particularly limited as long as the effect of the present invention is achieved, but is usually 0.1 parts by weight or more, preferably 0.5 parts by weight per 100 parts by weight of the composition for external use. As mentioned above, it is particularly preferably 1 part by weight or more, and the upper limit is usually 20 parts by weight or less, preferably 10 parts by weight or less, particularly preferably 7 parts by weight or less.

The fatty acid dextrin is not particularly limited as long as it is pharmaceutically acceptable. The dextrin includes lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid and other linear saturated fatty acids having 12 to 22 carbon atoms, isostearic acid, and the like. At least one fatty acid selected from the group consisting of branched fatty acids having 12 to 22 carbon atoms such as unsaturated fatty acids having 12 to 22 carbon atoms such as oleic acid, naturally occurring fatty acids such as coconut oil fatty acid, etc. Fatty acid dextrin is mentioned. Of these, dextrin palmitate, dextrin myristate, and dextrin stearate are preferable, and dextrin palmitate is particularly preferable in terms of excellent stability and usability.
The compounding amount of the fatty acid dextrin in the present invention is usually 0.01 to 15 parts by weight, preferably 0.01 to 10 parts by weight, more preferably 0.05 to 7.5 parts by weight with respect to 100 parts by weight of the composition for external use. Particularly preferred is a range of 0.1 to 4 parts by weight.

The composition for external use of the present invention can be used as cosmetics, pharmaceuticals, quasi-drugs and the like applied to the skin, and can be particularly suitably used for cosmetics. The dosage form may be any as long as it can be applied to the skin, and can be any dosage form such as liquid, ointment, gel, aerosol, cream and the like. For example, it can be used in lotions, emulsions, creams, packs, bath preparations, pastes, waxes, sheets, lotions and the like.
The external composition of the present invention contains a specific herbal medicine having an effect of suppressing hair growth or an extract thereof, and can be used for an application as an external composition for suppressing hair growth. For example, before or after depilation such as hair removal, depilation or shaving-related cosmetics, depilation such as paste, cream or aerosol, depilation such as wax, gel or sheet, depilation, depilation or shaving It can be used for products such as cosmetics such as face and body lotions and creams, and antiperspirant / deodorant cosmetics.

  The external composition of the present invention can be combined with various components as necessary. The type of such components is not particularly limited, and examples thereof include vitamins, local anesthetics, antipruritics, moisturizers, whitening agents, astringents, and antioxidants. Examples of suitable components in the present invention include the following components.

  Vitamin preparations: Retinol, retinol acetate, retinol palmitate, etc. (vitamin A), retinal, retinoic acid, methyl retinoic acid, ethyl retinoic acid, retinoic acid retinol, vitamin A oil, vitamin A fatty acid ester, etc. , Β-carotene, α-carotene, γ-carotene, δ-carotene, lycopene, zeaxanthin, cryptoxanthin, echinone and other provitamins A, dl-α-tocopherol, dl-α-tocopherol acetate, dl-succinate Vitamin E such as α-tocopherol, dl-α-tocopherol calcium succinate, riboflavin, flavin mononucleotide, flavin adenine dinucleotide, riboflavin butyrate, riboflavin tetrabutyrate, riboflavin Vitamin B2 such as sodium 5′-phosphate, riboflavin tetranicotinate, dl-α-tocopherol nicotinate, benzyl nicotinate, methyl nicotinate, β-butoxyethyl nicotinate, 1- (4-methyl nicotinate) Nicotinic acid such as phenyl) ethyl, vitamin C such as ascorbigen-A, ascorbyl stearate, ascorbyl palmitate, L-ascorbyl dipalmitate, vitamin D such as methyl hesperidin, ergocalciferol, cholecalciferol , Vitamin K such as phylloquinone, farnoquinone, γ-oryzanol, dibenzoyl thiamine, dibenzoyl thiamine hydrochloride, thiamine hydrochloride, thiamine cetyl hydrochloride, thiamine thiocyanate, thiamine laurie Hydrochloride, thiamine nitrate, thiamine monophosphate, thiamine lysine salt, thiamine triphosphate, thiamine monophosphate phosphate, thiamine monophosphate, thiamine diphosphate, thiamine diphosphate hydrochloride, thiamine triphosphate, Vitamin B1 such as thiamine triphosphate monophosphate, vitamin B6 such as pyridoxine hydrochloride, pyridoxine acetate, pyridoxal hydrochloride, 5'-phosphate pyridoxal hydrochloride, pyridoxamine hydrochloride, vitamin B12 such as cyanocobalamin, hydroxocobalamin, deoxyadenosylcobalamin Folic acid such as folic acid, pteroylglutamic acid, nicotinic acid such as nicotinic acid and nicotinamide, pantothenic acid, calcium pantothenate, pantothenyl alcohol (panthenolic acid) ), D-Panthesine, D-Panthetine, Coenzyme A, Pantothenic acids such as pantothenyl ethyl ether, biotins such as biotin and bioticin, ascorbic acid, sodium ascorbate, dehydroascorbic acid, sodium ascorbate phosphate Vitamin C, which is an ascorbic acid derivative such as magnesium ascorbate phosphate, and other vitamin-like agents such as carnitine, ferulic acid, α-lipoic acid and orotic acid.

  Local anesthetics: lidocaine, lidocaine hydrochloride, dibucaine, dibucaine hydrochloride, ethyl aminobenzoate, eucalyptus oil, eugenol, menthol, camphor, mint oil, etc.

  Antipruritics: crotamiton, camphor, thymol, menthol, polyoxyethylene lauryl ether, chlorpheniramine, diphenhydramine, dexamethasone, betamethasone, etc.

  Moisturizer: polyglycerin such as glycerin, 1,3-butylene glycol, propylene glycol, polyethylene glycol, diglycerin trehalose, sodium hyaluronate, heparin-like substance, sodium chondroitin sulfate, collagen, elastin, keratin, chitin, chitosan, etc. High molecular weight compounds, amino acids such as glycine, aspartic acid, arginine, natural moisturizing factors such as sodium lactate, urea, sodium pyrrolidonecarboxylate, lipids such as ceramide, cholesterol, phospholipid, chamomile extract, hamamelis extract, tea extract, perilla extract, etc. Plant extract and so on.

  Whitening agents: vitamin A or derivatives thereof, vitamin C or derivatives thereof, vitamin E or derivatives thereof, vitamins such as pantothenic acid or derivatives thereof, placenta; arbutin; kojic acid; cysteine; phytic acid; almond, ginkgo, oolong tea, age , Nettle, seaweed, gardenia, cucumber, wheat, rice, rice haiga, oryzanol, rice bran, perilla, peony, nematode, commune, tea, touki, hamamelis, safflower, buttonpi, touki, enoki, oyster (Diospyros kaki) Ingredients, extracts and essential oils.

Astringents: citric acid, tartaric acid, lactic acid, aluminum chloride, aluminum sulfate, allantochlorohydroxyaluminum, allantoindihydroxyaluminum, aluminum phenolsulfonic acid, zinc paraphenolsulfonic acid, zinc sulfate, zinc lactate, aluminum chlorohydroxide, tannin; , Hamelis, Altea, Acacia, Fennel, Wild Rose, Hypericum perforatum, Odrichosium, Orange, Valeriana, Parakeet, Raspberry, Kiwi, Burdock, Gentiana, Genpcho, Peonies, Shimoketsu, Seizuna, Japanese quail, Swan , Wild Time, Gobaisi, Tormentilla, Parietalia, Grapes, Loofah, Marronnier, Yag Magiku, saxifrage, mugwort, orchid, apple, lemon, components derived from plants such Rengesou, such as extracts and essential oils.
Antioxidants: Dibutylhydroxytoluene, butylhydroxyanisole, ascorbic acid, erythorbic acid, dl-α-tocopherol, disodium ethylenediaminetetraacetate dihydrate (hereinafter also referred to as sodium edetate), sorbic acid, sodium sulfite, L-cysteine hydrochloride and the like.

  These components can be used alone or in combination of two or more. Moreover, those compounding amounts are not particularly limited as long as the effects of the present invention are obtained, but can be suitably selected and used as long as the upper limit compounding amount allowed by the Pharmaceutical Affairs Law is desirable. Specifically, it is prepared according to the purpose from the range of usually 0.001 to 50 parts by weight, preferably 0.001 to 40 parts by weight, more preferably 0.001 to 30 parts by weight per 100 parts by weight of the composition for external use. be able to.

  The preparation method of the composition for external use of the present invention is not particularly limited, and can be prepared by a conventional method by appropriately selecting and blending various components necessary for preparing a normal composition for external use. Moreover, the application amount and usage of the external composition of the present invention to the outer skin are not particularly limited, and it can be used by applying an appropriate amount to the outer skin such as skin several times a day.

  Although the composition for external use of this invention should just be normally provided with the liquid property of pH 2-9, from a viewpoint of the mild irritation | stimulation with respect to skin and a viscosity, and the good feeling of skin use, Preferably it is pH 3-8, More preferably It is desirable that the pH is 4 to 8, particularly preferably 5 to 8. The viscosity is BL type viscometer, No. When it is measured for 1 minute at 60 rpm with 4 rotors, it may be provided with a viscosity of 500 to 200000 mPa. However, from the viewpoint of finger picking property and ease of application, it is preferably 1000 to 150,000 mPa, more preferably 1000 to 100000 mPa is preferred.

  EXAMPLES The present invention will be specifically described below with reference to examples, but these examples do not limit the scope of the present invention. In addition, a compounding quantity etc. represent weight% altogether about purified water or a thing without the description of a unit.

  The formulation examples are given below. In addition, the compounding quantity in a following example represents weight% altogether about purified water or the thing without the description of a unit especially.

Example 1 (Emulsion)
Smell extract (Iris root extract) 1.0
Soybean extract 1.0
Hinogi extract 1.0
Allantoin 0.1
Acrylic acid / alkyl methacrylate copolymer 0.4
Hydroxyethyl cellulose 0.2
1,3-butylene glycol 3.0
Glycerin 2.0
Polyoxyethylene hydrogenated castor oil 0.5
Sodium edetate 0.05
Dibutylhydroxytoluene 0.01
Methylphenylpolysiloxane 3.0
Triethanolamine 0.25
Cha extract 0.1
P-Hydroxybenzoate 0.20
Perfume Appropriate amount Purified water Remaining

Example 2 (gel)
Smell Iris Extract (Iris Root Extract) 5.0
Allantoin 0.01
Carboxyvinyl polymer 0.35
DL-malic acid 0.01
Aloe extract 0.01
Cha extract 0.01
Absolute ethanol 1.0
Polyoxyethylene hydrogenated castor oil 0.4
L-Arginine 0.35
P-Hydroxybenzoate 0.20
Perfume Appropriate amount Purified water Remaining

Example 3 (Cream)
Hinogi Extract 3.0
Cuckoo extract 0.5
Allantoin 0.001
Tocopherol acetate 0.2
dl-camphor 0.8
Carboxyvinyl polymer 0.8
Glycerin 3.0
Cetanol 3.0
Octyl palmitate 22.0
Glycerol monostearate 3.5
Polyoxyethylene cetyl ether 3.5
Triethanolamine 1.1
Sodium edetate 0.05
P-Hydroxybenzoate ester 0.2
Purified water remaining

Example 4 (Lotion)
Smell extract (Iris root extract) 0.1
Soybean extract 0.1
Hinogi extract 0.1
Allantoin 0.01
1,3-butylene glycol 40.0
Glycerin 10.0
Polyethylene glycol 1500 1.0
Citric anhydride 0.15
Sodium hydrogen phosphate 0.45
P-Hydroxybenzoate 0.05
Purified water remaining

Example 5 Hair Removal Cream Smell Extract (Iris Root Extract) 0.001
Soybean extract 0.001
Hinogi extract 0.001
Allantoin 0.1
Calcium thioglycolate 4.0
Cetyl alcohol 6.0
Vaseline 15.0
Liquid paraffin 10.0
Polyoxyethylene oleyl alcohol ether 4.0
Polyoxyethylene stearyl alcohol AE 2.0
Purified water remaining

Example 6 Hair Removal Aerosol Nio Iris Extract (Iris Root Extract) 0.02
Soybean extract 0.02
Dokudami Extract 0.01
Allantoin 0.3
Dipropylene glycol 10.0
Thioglycolic acid 6.0
Sodium hydroxide 4.5
Polyoxyethylene cetyl alcohol ether 3.0
Liquid paraffin 2.0
LPG 6.0
Dimethyl ether 2.0
Perfume Appropriate amount Purified water Remaining

Example 7
Carboxyvinyl polymer 0.35
Smell extract (Iris root extract) 1.0
Soybean extract 1.0
Hinogi extract 1.0
Allantoin 0.01
Absolute ethanol 1.0
Polyoxyethylene hydrogenated castor oil 0.4
P-Hydroxybenzoate 0.20
Perfume Appropriate amount Purified water Remaining

Example 8
Carboxyvinyl polymer 0.35
Smell extract (Iris root extract) 3.0
Allantoin 0.01
Absolute ethanol 1.0
Polyoxyethylene hydrogenated castor oil 0.4
P-Hydroxybenzoate 0.20
Perfume Appropriate amount Purified water Remaining

Mouse hair growth test The back of 7-week-old C3H / HeN mice with a resting hair cycle was removed using an electric clipper and an electric shaver so as not to damage the skin, and 10 mice per group were used for the experiment. did. From the next day after depilation, 0.1 mL of each test sample shown in Table 1 was applied to the depilation site (2 cm × 4 cm) twice a day for 5 days per week. The hair growth area ratio (%) showing the hair growth inhibitory effect of each test sample is determined by measuring the area of the hair growth portion at the hair removal site of each test sample and the control sample, and the ratio of the hair growth area to the area of the hair removal site. Then, how much each test sample was able to suppress hair growth as compared with the control sample was calculated by the following calculation formula 1. Table 1 shows the average hair growth area ratio (%) on the 19th day from the start of application of each test sample.

Formula 1
Hair growth area ratio (%) = (Area of hair growth in test sample / Area of hair removal site) ÷ (Area of hair growth in control sample / Area of hair removal site) × 100

  From the result of Table 1, it was shown by containing allantoin that the hair growth inhibitory effect of a squirrel extract, a Hyogi extract, and a soybean extract is enhanced. Therefore, it is recognized that the composition for external use containing a squirrel extract, cypress extract or soybean extract together with allantoin exhibits an excellent hair growth inhibitory effect.

Hair growth inhibition test and rough skin improvement test 42 subjects (12 people per group) who were 20-39-year-old females who routinely shaved their body hair with a razor. On the first day of the test, the necks of both legs were shaved, and the test sample 8, test sample 9 or 10 was applied to the entire shin of the right leg once or more for 29 days continuously. . On the other hand, a control sample (1,3 butylene glycol 3.0 wt%, glycerin 2.0 wt%, remaining amount of purified water) was applied to the left leg shin similarly to the right leg shin. Until the 23rd day after the start of application, the subjects were asked to perform shaving at regular intervals. On the 23rd day after the start of application, all the shins of all the subjects were shaved with a razor at the same time, and after the start of application without shaving for 6 days, the length of the hair on both necks that had grown on the 29th day Was measured using a microscope (VHX-100, manufactured by Keyence Corporation), an average value of the lengths of 20 hairs randomly selected for each subject was determined, and a growth rate of the hair was calculated. The growth rate (%) of body hair was determined by the following formula.
On the 23rd day after the start of application, immediately after shaving all the subjects together, the sample was applied to the neck of both legs, and 8 hours after application of the sample, the amount of horny moisture (Sicon-200, manufactured by IBS) was measured. did. Based on the measured amount of stratum corneum, the skin roughness improvement rate (%) was calculated. The rough skin improvement rate (%) was determined by the following formula. Table 2 shows the average values of the growth rate (%) of body hair and the improvement rate of rough skin (%) of each subject.

Growth rate of body hair (%) = (length of hair on right leg shin [test sample application part] / length of hair on left leg shin [control sample application part]) × 100
Rough skin improvement rate (%) = (Keratin water content of right leg shin [test sample application part] / (Keratin water content of left leg shin [control sample application part]) × 100

  From the results shown in Table 2, the composition for external use containing odoris extract, cypress extract, and soybean extract together with allantoin exhibits an excellent hair growth inhibitory effect and is superior to a commercial product containing only soybean extract. showed that. Moreover, in the external composition of this invention, even if it repeated shaving treatment of body hair, it was confirmed that the shaved part has sufficient water retention power and can improve rough skin, and is a safe composition.

Claims (3)

A composition for external use containing allantoin and a hair growth inhibitor comprising at least one herbal medicine selected from soybeans, scented oils, and cypresses, or an extract thereof. A composition for external use containing allantoin and a hair growth inhibitor comprising at least one herbal medicine selected from scented squirrels and cypress, or an extract thereof. It is a composition for body hair growth suppression, The composition for external use of any one of Claims 1-2.