JP4102439B2 - 心拍出量拡大型ペースメーカ - Google Patents
心拍出量拡大型ペースメーカ Download PDFInfo
- Publication number
- JP4102439B2 JP4102439B2 JP52963897A JP52963897A JP4102439B2 JP 4102439 B2 JP4102439 B2 JP 4102439B2 JP 52963897 A JP52963897 A JP 52963897A JP 52963897 A JP52963897 A JP 52963897A JP 4102439 B2 JP4102439 B2 JP 4102439B2
- Authority
- JP
- Japan
- Prior art keywords
- pulse
- excitation
- heart
- electrodes
- stimulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000000747 cardiac effect Effects 0.000 title claims description 57
- 210000003205 muscle Anatomy 0.000 claims abstract description 10
- 230000000638 stimulation Effects 0.000 claims description 99
- 230000005284 excitation Effects 0.000 claims description 91
- 230000004044 response Effects 0.000 claims description 21
- 230000007274 generation of a signal involved in cell-cell signaling Effects 0.000 claims description 13
- 230000033001 locomotion Effects 0.000 claims description 13
- 230000000694 effects Effects 0.000 claims description 8
- 230000036982 action potential Effects 0.000 claims description 5
- 230000010247 heart contraction Effects 0.000 claims description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 2
- 230000004217 heart function Effects 0.000 claims description 2
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- 208000024891 symptom Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 16
- 230000008602 contraction Effects 0.000 abstract description 9
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- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
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- 230000006793 arrhythmia Effects 0.000 description 1
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- 229910052799 carbon Inorganic materials 0.000 description 1
- 231100001012 cardiac lesion Toxicity 0.000 description 1
- 210000004413 cardiac myocyte Anatomy 0.000 description 1
- 229940030602 cardiac therapy drug Drugs 0.000 description 1
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- 238000013461 design Methods 0.000 description 1
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- 230000000004 hemodynamic effect Effects 0.000 description 1
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- 210000005246 left atrium Anatomy 0.000 description 1
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- 230000008672 reprogramming Effects 0.000 description 1
- 210000002235 sarcomere Anatomy 0.000 description 1
- 210000001013 sinoatrial node Anatomy 0.000 description 1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
- A61N1/36514—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure
- A61N1/36564—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by blood pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/3627—Heart stimulators for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/3628—Heart stimulators using sub-threshold or non-excitatory signals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/00234—Surgical instruments, devices or methods for minimally invasive surgery
- A61B2017/00238—Type of minimally invasive operation
- A61B2017/00243—Type of minimally invasive operation cardiac
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/02—Surgical instruments, devices or methods for holding wounds open, e.g. retractors; Tractors
- A61B2017/0237—Surgical instruments, devices or methods for holding wounds open, e.g. retractors; Tractors for heart surgery
- A61B2017/0243—Surgical instruments, devices or methods for holding wounds open, e.g. retractors; Tractors for heart surgery for immobilizing local areas of the heart, e.g. while it beats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
- A61N1/36514—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure
- A61N1/36557—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by chemical substances in blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
- A61N1/368—Heart stimulators controlled by a physiological parameter, e.g. heart potential comprising more than one electrode co-operating with different heart regions
Landscapes
- Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Physiology (AREA)
- Biophysics (AREA)
- Electrotherapy Devices (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Paper (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Percussion Or Vibration Massage (AREA)
- Medicines Containing Plant Substances (AREA)
- Advance Control (AREA)
- Compositions Of Oxide Ceramics (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2639296P | 1996-09-16 | 1996-09-16 | |
| IL60/026,392 | 1996-09-17 | ||
| IL119261 | 1996-09-17 | ||
| IL11926196A IL119261A0 (en) | 1996-09-17 | 1996-09-17 | Electrical muscle controller |
| PCT/IL1997/000236 WO1998010832A1 (en) | 1996-09-16 | 1997-07-09 | Cardiac output enhanced pacemaker |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008022802A Division JP2008149161A (ja) | 1996-09-16 | 2008-02-01 | 心臓のペースを調節する装置、及び心臓ペースを調整する装置を操作する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001501490A JP2001501490A (ja) | 2001-02-06 |
| JP2001501490A5 JP2001501490A5 (https=) | 2005-03-10 |
| JP4102439B2 true JP4102439B2 (ja) | 2008-06-18 |
Family
ID=26323305
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP52963897A Expired - Lifetime JP4102439B2 (ja) | 1996-09-16 | 1997-07-09 | 心拍出量拡大型ペースメーカ |
| JP10513446A Pending JP2001501503A (ja) | 1996-09-16 | 1997-07-09 | 筋肉の収縮性を制御するための装置および方法 |
| JP51344898A Expired - Lifetime JP4065027B2 (ja) | 1996-09-16 | 1997-07-09 | 心筋のフェンシング |
| JP52963797A Pending JP2001506870A (ja) | 1996-09-16 | 1997-07-09 | 心拍出量コントローラ |
| JP51344798A Pending JP2001507951A (ja) | 1996-09-16 | 1997-07-09 | 筋肉の収縮性を制御するための薬物―装置の組み合わせ |
| JP2007206282A Expired - Lifetime JP4589365B2 (ja) | 1996-09-16 | 2007-08-08 | 心拍出量コントローラ |
| JP2008022802A Withdrawn JP2008149161A (ja) | 1996-09-16 | 2008-02-01 | 心臓のペースを調節する装置、及び心臓ペースを調整する装置を操作する方法 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10513446A Pending JP2001501503A (ja) | 1996-09-16 | 1997-07-09 | 筋肉の収縮性を制御するための装置および方法 |
| JP51344898A Expired - Lifetime JP4065027B2 (ja) | 1996-09-16 | 1997-07-09 | 心筋のフェンシング |
| JP52963797A Pending JP2001506870A (ja) | 1996-09-16 | 1997-07-09 | 心拍出量コントローラ |
| JP51344798A Pending JP2001507951A (ja) | 1996-09-16 | 1997-07-09 | 筋肉の収縮性を制御するための薬物―装置の組み合わせ |
| JP2007206282A Expired - Lifetime JP4589365B2 (ja) | 1996-09-16 | 2007-08-08 | 心拍出量コントローラ |
| JP2008022802A Withdrawn JP2008149161A (ja) | 1996-09-16 | 2008-02-01 | 心臓のペースを調節する装置、及び心臓ペースを調整する装置を操作する方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6233484B1 (https=) |
| EP (5) | EP1011795B1 (https=) |
| JP (7) | JP4102439B2 (https=) |
| AT (2) | ATE460204T1 (https=) |
| AU (5) | AU3357297A (https=) |
| DE (2) | DE69739833D1 (https=) |
| WO (5) | WO1998010831A1 (https=) |
Families Citing this family (120)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL119261A0 (en) | 1996-09-17 | 1996-12-05 | New Technologies Sa Ysy Ltd | Electrical muscle controller |
| IL125424A0 (en) | 1998-07-20 | 1999-03-12 | New Technologies Sa Ysy Ltd | Pacing with hemodynamic enhancement |
| US9289618B1 (en) | 1996-01-08 | 2016-03-22 | Impulse Dynamics Nv | Electrical muscle controller |
| US8825152B2 (en) | 1996-01-08 | 2014-09-02 | Impulse Dynamics, N.V. | Modulation of intracellular calcium concentration using non-excitatory electrical signals applied to the tissue |
| US8321013B2 (en) * | 1996-01-08 | 2012-11-27 | Impulse Dynamics, N.V. | Electrical muscle controller and pacing with hemodynamic enhancement |
| JP4175662B2 (ja) | 1996-01-08 | 2008-11-05 | インパルス ダイナミクス エヌ.ヴイ. | 電気的筋肉制御装置 |
| US7167748B2 (en) | 1996-01-08 | 2007-01-23 | Impulse Dynamics Nv | Electrical muscle controller |
| US9713723B2 (en) | 1996-01-11 | 2017-07-25 | Impulse Dynamics Nv | Signal delivery through the right ventricular septum |
| US6415178B1 (en) | 1996-09-16 | 2002-07-02 | Impulse Dynamics N.V. | Fencing of cardiac muscles |
| ZA976113B (en) | 1996-09-16 | 1998-03-19 | New Technologies Sa Ysy Ltd | Drug-device combination for controlling the contractility of muscles. |
| DE69739833D1 (de) | 1996-09-16 | 2010-05-20 | Impulse Dynamics Nv | Schrittmacher zur erhöhung des herzzeitvolumens |
| US6463324B1 (en) | 1996-09-16 | 2002-10-08 | Impulse Dynamics N. V. | Cardiac output enhanced pacemaker |
| WO2000053257A1 (en) | 1999-03-05 | 2000-09-14 | Impulse Dynamics Nv | Blood glucose level control |
| US7006871B1 (en) | 1997-07-16 | 2006-02-28 | Metacure N.V. | Blood glucose level control |
| EP1779890B8 (en) | 1997-07-16 | 2009-07-08 | Metacure Limited | Smooth muscle controller |
| US6711436B1 (en) | 1997-08-08 | 2004-03-23 | Duke University | Compositions, apparatus and methods for facilitating surgical procedures |
| AU758370B2 (en) | 1997-08-08 | 2003-03-20 | Duke University | Compositions, apparatus and methods for facilitating surgical procedures |
| US6725093B1 (en) | 1998-11-06 | 2004-04-20 | Impulse Dynamics N.V. | Regulation of excitable tissue control of the heart based on physiological input |
| WO2000027472A1 (en) | 1998-11-06 | 2000-05-18 | Impulse Dynamics Nv | Trigger-based regulation of excitable tissue control in the heart |
| US6675043B1 (en) | 1998-11-06 | 2004-01-06 | Impulse Dynamics N.V. | Sensor-based regulation of excitable tissue control of the heart |
| US6463323B1 (en) | 1998-11-12 | 2002-10-08 | Em Vascular, Inc. | Electrically mediated angiogenesis |
| US6152882A (en) * | 1999-01-26 | 2000-11-28 | Impulse Dynamics N.V. | Apparatus and method for chronic measurement of monophasic action potentials |
| EP1825880B1 (en) | 1999-03-05 | 2016-05-11 | Metacure Limited | Blood glucose level control |
| US8666495B2 (en) | 1999-03-05 | 2014-03-04 | Metacure Limited | Gastrointestinal methods and apparatus for use in treating disorders and controlling blood sugar |
| US9101765B2 (en) | 1999-03-05 | 2015-08-11 | Metacure Limited | Non-immediate effects of therapy |
| US8019421B2 (en) * | 1999-03-05 | 2011-09-13 | Metacure Limited | Blood glucose level control |
| US8700161B2 (en) | 1999-03-05 | 2014-04-15 | Metacure Limited | Blood glucose level control |
| US6370430B1 (en) | 1999-03-25 | 2002-04-09 | Impulse Dynamics N.V. | Apparatus and method for controlling the delivery of non-excitatory cardiac contractility modulating signals to a heart |
| US6263242B1 (en) | 1999-03-25 | 2001-07-17 | Impulse Dynamics N.V. | Apparatus and method for timing the delivery of non-excitatory ETC signals to a heart |
| US6292704B1 (en) | 1999-05-25 | 2001-09-18 | Impulse Dynamics N. V. | High capacitance myocardial electrodes |
| US6304777B1 (en) * | 1999-05-26 | 2001-10-16 | Impulse Dynamics N.V. | Induction of cardioplegia applied electrical signals |
| US6973347B1 (en) | 1999-05-26 | 2005-12-06 | Impulse Dynamics Nv | Local cardiac motion control using applied electrical signals and mechanical force |
| US6442424B1 (en) | 1999-05-26 | 2002-08-27 | Impulse Dynamics N.V. | Local cardiac motion control using applied electrical signals |
| US6285906B1 (en) | 1999-05-26 | 2001-09-04 | Impulse Dynamics N. V. | Muscle contraction assist device |
| US8014858B1 (en) | 1999-05-26 | 2011-09-06 | Impulse Dynamics N.V. | Shockless defibrillation |
| US6223072B1 (en) | 1999-06-08 | 2001-04-24 | Impulse Dynamics N.V. | Apparatus and method for collecting data useful for determining the parameters of an alert window for timing delivery of ETC signals to a heart under varying cardiac conditions |
| US6233487B1 (en) | 1999-06-08 | 2001-05-15 | Impulse Dynamics N.V. | Apparatus and method for setting the parameters of an alert window used for timing the delivery of ETC signals to a heart under varying cardiac conditions |
| US6360126B1 (en) | 1999-08-20 | 2002-03-19 | Impulse Dynamics N.V. | Apparatus and method for controlling the delivery of contractility modulating non-excitatory signals to the heart |
| US6560489B2 (en) | 1999-08-24 | 2003-05-06 | Em Vascular, Inc. | Therapeutic device and method for treating diseases of cardiac muscle |
| US6556872B2 (en) | 1999-08-24 | 2003-04-29 | Ev Vascular, Inc. | Therapeutic device and method for treating diseases of cardiac muscle |
| AU1049901A (en) * | 1999-10-25 | 2001-05-08 | Impulse Dynamics N.V. | Cardiac contractility modulation device having anti-arrhythmic capabilities and a method of operating thereof |
| US6993385B1 (en) * | 1999-10-25 | 2006-01-31 | Impulse Dynamics N.V. | Cardiac contractility modulation device having anti-arrhythmic capabilities and a method of operating thereof |
| US7027863B1 (en) | 1999-10-25 | 2006-04-11 | Impulse Dynamics N.V. | Device for cardiac therapy |
| US6480737B1 (en) | 1999-12-29 | 2002-11-12 | Impulse Dynamics Nv | Field delivery safety system using detection of atypical ECG |
| AU2023201A (en) | 1999-12-29 | 2001-07-16 | Impulse Dynamics N.V. | Field delivery safety system using detection of atypical ecg |
| EP1267992A4 (en) * | 2000-04-06 | 2008-12-10 | Impulse Dynamics Nv | CONTRACTION IMPROVEMENT USING CONTROLLABLE TISSUE AND STIMULATION IN MULTIPLE SITES |
| WO2001082771A2 (en) | 2000-05-04 | 2001-11-08 | Impulse Dynamics N.V. | Signal delivery through the right ventricular septum |
| MXPA03004180A (es) | 2000-11-13 | 2004-12-02 | Boehm Frank H Jr | Dispositivo y metodo para la fusion intercorporal lumbar. |
| EP1357971B1 (en) | 2001-01-05 | 2015-05-20 | Metacure Limited | Regulation of eating habits |
| EP2298166B1 (en) | 2001-04-18 | 2014-01-15 | Metacure Limited | Apparatus for analysis of eating habits |
| CA2442352A1 (en) * | 2002-09-26 | 2004-03-26 | Reg Macquarrie | Poly-(vinyl alcohol) based meat processing films |
| US11439815B2 (en) | 2003-03-10 | 2022-09-13 | Impulse Dynamics Nv | Protein activity modification |
| US7840262B2 (en) | 2003-03-10 | 2010-11-23 | Impulse Dynamics Nv | Apparatus and method for delivering electrical signals to modify gene expression in cardiac tissue |
| US7006864B2 (en) * | 2003-06-17 | 2006-02-28 | Ebr Systems, Inc. | Methods and systems for vibrational treatment of cardiac arrhythmias |
| JP4943841B2 (ja) | 2003-06-20 | 2012-05-30 | メタキュアー リミティド | 障害を治療する上で使用するための胃腸方法及び器具 |
| US8792985B2 (en) | 2003-07-21 | 2014-07-29 | Metacure Limited | Gastrointestinal methods and apparatus for use in treating disorders and controlling blood sugar |
| US7292888B2 (en) | 2003-08-11 | 2007-11-06 | Medtronic, Inc. | Cardiac stimulation during a refractory period |
| US7184830B2 (en) * | 2003-08-18 | 2007-02-27 | Ebr Systems, Inc. | Methods and systems for treating arrhythmias using a combination of vibrational and electrical energy |
| US20050055058A1 (en) * | 2003-09-08 | 2005-03-10 | Mower Morton M. | Method and apparatus for intrachamber resynchronization |
| US7130687B2 (en) * | 2003-10-24 | 2006-10-31 | Medtronic, Inc | Implantable medical device and method for delivering therapy for sleep-disordered breathing |
| US8352031B2 (en) | 2004-03-10 | 2013-01-08 | Impulse Dynamics Nv | Protein activity modification |
| WO2006119467A2 (en) | 2005-05-04 | 2006-11-09 | Impulse Dynamics Nv | Protein activity modification |
| US11779768B2 (en) | 2004-03-10 | 2023-10-10 | Impulse Dynamics Nv | Protein activity modification |
| US7765001B2 (en) * | 2005-08-31 | 2010-07-27 | Ebr Systems, Inc. | Methods and systems for heart failure prevention and treatments using ultrasound and leadless implantable devices |
| CA2594673A1 (en) | 2004-12-09 | 2006-07-13 | Impulse Dynamics Nv | Protein activity modification |
| US7558631B2 (en) * | 2004-12-21 | 2009-07-07 | Ebr Systems, Inc. | Leadless tissue stimulation systems and methods |
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