JP4087783B2 - Skin collagen dispersion - Google Patents

Description

The present invention relates to a skin collagen dispersion using a fish-derived collagen dispersion.

Conventionally, collagen used in various applications has generally been extracted from the collagen tissue of mammals such as cattle and pigs, but since the BSE (so-called mad cow disease) problem has occurred in recent years, Mammal-derived collagen tends to be avoided, and fish-derived collagen has attracted attention.
As fish-derived collagen, for example, those made from the skin of fish such as flounder, cod, tuna, shark, salmon, etc. have been known for a long time. There is a drawback of having a fishy odor. For example, in applications such as cosmetic raw materials, considering the fact that the odor gives an unpleasant sensation at the time of use, an amount sufficient to fully develop the effects of collagen (such as moisture retention) It could not be blended.

Therefore, the use of fish scales as a raw material has been studied as a means for eliminating the fish odor peculiar to fish-derived collagen. It is known that fish scales usually contain about 50% of ash mainly composed of calcium phosphate (hydroxyapatite) and about 40% of protein, and about 80% of protein is collagen. As collagen made from fish scales, acid-soluble fish scale collagen obtained by performing a step of decalcifying fish scales, a step of treating with an acidic aqueous solution or pepsin and a step of recovering collagen at 15 ° C. or lower, Pepsin-soluble fish scale collagen and acid-insoluble fish scale collagen have been reported (see Patent Documents 1, 2, and 3).
JP-A-5-93000 Japanese Patent Laid-Open No. 5-125100 JP-A-5-155900

  However, when collagen is used as an aqueous solution, fish-derived soluble collagen has a disadvantage that it has a lower denaturation temperature and is easily gelatinized compared to mammalian-derived soluble collagen. Specifically, in soluble collagen derived from mammals, denaturation occurs at a temperature close to or slightly higher than human body temperature, but in fish-derived soluble collagen, degeneration occurs at a temperature lower than human body temperature. Therefore, for example, when collagen is used as an aqueous solution in applications such as cosmetic raw materials, fish-derived collagen is denatured by body temperature when attached to the skin, and the original effects of collagen (such as moisture retention) are sufficiently obtained. There was a problem that it could not be expressed.

Therefore, the problem to be solved by the present invention is to disperse collagen that can be substituted for an aqueous collagen solution, which is derived from fish but can hardly exhibit denaturation even at a temperature near the human body temperature and can fully exhibit the original properties of collagen. An object of the present invention is to provide a skin collagen dispersion in which the body can be used for skin .

The present inventor has intensively studied to solve the above problems. As a result, a dispersion in which insoluble collagen obtained from fish scales is dispersed as fine particles in a solvent can express the original properties of collagen while overcoming the disadvantage of a collagen aqueous solution derived from fish that has a low denaturation temperature. The present inventors have completed the present invention by confirming that such a collagen dispersion can be used in the same manner as a collagen aqueous solution.
That is, in the collagen dispersion for skin according to the present invention, fine particles of insoluble collagen having a particle diameter of 200 μm or less obtained by pulverizing fish scales having an ash content of 2% by weight or less and an oil and fat content of 0.3% by weight or less are solvent. It is dispersed in and contains water-soluble collagen as a dispersion stabilizer .

According to the present invention, it is possible to provide a collagen dispersion that can be substituted for an aqueous collagen solution, which is derived from fish but hardly denatures even at a temperature near the human body temperature, and can sufficiently exhibit the original properties of collagen. it can.

Hereinafter, will be explained in detail about the dispersion according to the present invention, the scope of the present invention should not be restricted to these descriptions, even with the addition to the following examples, appropriate modifications performed without departing from the spirit of the present invention Can do.
[Dispersion of the present invention]
The dispersion of the present invention is a collagen dispersion in which fine particles of insoluble collagen obtained from fish scales are dispersed in a solvent. The dispersion of the present invention, for example, is limited to what can be obtained easily by the term granulation method made you later in the Manufacturing Method of dispersion of the present invention], obtained in the process It is not a thing.

  The fish scale used as a raw material for obtaining the fine particles of the insoluble collagen is not particularly limited. For example, in addition to the red sea bream of the Thai family and the red sea bream, the same species Chidai, Hirokodai, the black sea bream, Scales collected from various fishes such as kitinu, red sea bream, and red sea bream daisies can be used. In addition, it is preferable that the said fish scale is a thing with high freshness, for example, after extract | collecting, it is preferable to use as a raw material the thing refrigerated storage, Preferably it preserve | saved frozen. Usually, the collected fish scales are contaminated with, for example, dorsal fins and caudal fins, or have surplus proteins on their surfaces. It is preferable that

  The fish scale used as the raw material for obtaining the insoluble collagen fine particles should have an ash content of 2% by weight or less, preferably 1% by weight or less, and a fat or oil content of 0.3% by weight or less. If the fish phosphorus used as the raw material has an ash content exceeding 2% by weight, a large amount of inorganic substances are contained, and pulverization and dispersion may not be performed satisfactorily. Moreover, when the fish phosphorus used as a raw material exceeds 0.3% by weight of fat and oil, the resulting dispersion may have a fishy odor. In order to set the ash content of fish phosphorus in the above range, a decalcification process for removing inorganic substances such as calcium phosphate contained in fish scales may be performed, and in order to set the fat and oil content in the above range, a degreasing process may be performed.

In the decalcification treatment, the method is not particularly limited, and for example, it may be performed by a usual method such as stirring fish scales to be treated in the treatment liquid for 24 to 48 hours. For example, hydrochloric acid, ethylenediaminetetraacetic acid, disodium ethylenediaminetetraacetic acid, tetrasodium ethylenediaminetetraacetic acid, or the like can be used as the treatment liquid used in the deashing treatment, but from the viewpoint of cost reduction, an aqueous hydrochloric acid solution is used. Is preferred. The amount of the treatment liquid used may be set as appropriate and is not particularly limited. The decalcification treatment may be performed a plurality of times as necessary, or may be washed with water after decalcification as necessary.
In the degreasing treatment, the method is not particularly limited, and for example, it may be carried out by a usual method such as stirring fish scales to be treated in the treatment liquid for 3 to 48 hours. As the treatment liquid used for the degreasing treatment, for example, an organic solvent such as ethanol or acetone, an alkaline liquid such as sodium hydroxide or potassium hydroxide, or a surfactant such as a nonionic surfactant can be used. The amount of the treatment liquid used may be set as appropriate and is not particularly limited. The degreasing treatment may be performed a plurality of times as necessary, or may be washed with water after degreasing as necessary.

The fine particles of the insoluble collagen may be those obtained by pulverizing the fish scales described above, or the water-soluble collagen extracted from the fish scales described above by, for example, enzyme treatment or the like is insolubilized again to form insoluble collagen, Although this may be refined, from the viewpoint of production efficiency and cost, the former fish phosphorus is preferably pulverized. A dispersion in which fine particles of insoluble collagen are formed by pulverizing fish phosphorus as described above can be easily obtained by the production method of the present invention described later in the section of [Method for producing dispersion of the present invention].
The insoluble collagen fine particles preferably have a particle size of 200 μm or less. If the particle diameter of the fine particles of insoluble collagen exceeds 200 μm, it may not be possible to uniformly disperse in the solvent. More preferably, the particle diameter of the insoluble collagen fine particles is 100 μm or less.

The amount of the insoluble collagen fine particles in the dispersion of the present invention may be appropriately set according to the use, but is preferably 0.3 to 2% by weight, for example.
The dispersion of the present invention preferably contains water-soluble collagen as a dispersion stabilizer. Thereby, the dispersibility of the insoluble collagen fine particles in the solvent is improved, and a more uniform dispersion is obtained.
The water-soluble collagen used as the dispersion stabilizer is not particularly limited, and examples thereof include enzyme-solubilized collagen and collagen subjected to chemical modification such as succinylation and phthalation. The water-soluble collagen used as the dispersion stabilizer is preferably obtained from fish phosphorus as a raw material, as in the case of the insoluble collagen fine particles.

When the dispersion of the present invention also contains water-soluble collagen as a dispersion stabilizer, the content is preferably 0.1 to 2% by weight in the dispersion. If it exceeds 2% by weight, the fluidity tends to be lowered and the handling tends to be difficult. On the other hand, if it is less than 0.1%, the dispersibility may not be improved sufficiently.
The solvent in the dispersion of the present invention is preferably water, but is not limited thereto, for example, alcohols such as ethanol and butylene glycol, or a mixture of these alcohols and water, The mixed solution or a solution containing an organic compound or inorganic compound soluble in water may be used.

[Method for producing dispersion of the present invention]
The method for producing a dispersion according to the present invention includes a refinement step in which fish scale is used as a raw material and the raw material is pulverized to obtain fine particles of insoluble collagen; a dispersion step in which the fine particles obtained in the refinement step are dispersed in a solvent; Is included.
In the method for producing a dispersion of the present invention, fish phosphorus used as a raw material is as described above in the section of [Dispersion of the present invention]. In addition, although each process (decalcification process, degreasing process, washing | cleaning) mentioned above given to the collected fish phosphorus as needed may be performed in any order, it performs in order of a washing | cleaning, a deashing process, and a degreasing process. It is common.

  The method for pulverizing the raw material fish phosphorus in the miniaturization step is not particularly limited. For example, a method using a jet mill, a liquid jet mill, a ball mill, a high-speed rotary mill, a stirring mill, a high-speed homogenizer, or the like, ultrasonic Can be carried out by a known method such as a method using a method, a freeze pulverization method, or a combination of these methods, preferably a dry pulverization method using a dry pulverizer (hereinafter simply referred to as “dry pulverization method”). Or a wet pulverization method using a high-pressure injection processing apparatus (hereinafter, also simply referred to as “wet pulverization method”) may be employed. Note that the pulverization of fish phosphorus in the refining step is not necessarily performed in one stage. For example, the pulverization may be performed in two or more stages, for example, by first crushing into coarse particles and further pulverizing the coarse particles. It may be. In the miniaturization step, if necessary, only those having a desired particle size may be classified after pulverization.

In the micronization step, the raw fish phosphorus used for pulverization can be dried in advance regardless of the pulverization method. However, when the raw fish phosphorus is dried, it is preferably performed at a temperature at which collagen denaturation does not occur. Specifically, it is preferably dried at 60 ° C. or lower.
In the dispersion step, the method for dispersing the fine particles obtained in the refinement step in the solvent is not particularly limited. For example, a conventionally known means for dispersing the particles in the solvent such as using a homogenizer is employed. Can do. The solvent is as described above in the section [Dispersion of the present invention].

Hereinafter, the aspect which performs the said refinement | miniaturization process by the dry-type grinding | pulverization method, and the aspect which performs the said refinement | miniaturization process by the wet-grinding method are demonstrated in detail. These embodiments are preferred embodiments in the method for producing the dispersion of the present invention.
In an embodiment in which the micronization step is performed by a dry pulverization method, for example, the raw material fish phosphorus is first dried to such an extent that it can be dry pulverized (for example, a water content of about 5% or less), and then the obtained drying After finely pulverizing fish phosphorus with a dry fine pulverizer (for example, “Tornado Mill” manufactured by Nikkiso Co., Ltd.), the fine particles obtained may be dispersed in a solvent.
In an embodiment in which the micronization step is performed by a wet pulverization method, for example, a raw liquid fish phosphorus is roughly crushed to obtain a dispersion liquid dispersed in a solvent, and then the obtained dispersion liquid is subjected to a high-pressure injection processing apparatus (for example, , Using "Ultimizer System" manufactured by Sugino Machine Co., Ltd.) and causing the dispersed liquids to collide with each other, or the ejected liquid dispersion to collide with a wall such as a collision plate or the bottom of the receiver. Thus, the coarse particles in the dispersion liquid may be refined by a physical force (a shear flow generated in the ejected dispersion liquid or an impact force generated in the collision). That is, in this aspect, the miniaturization process and the dispersion process are performed in the high-pressure injection processing apparatus.

In the embodiment in which the micronization step is performed by a wet pulverization method, a specific method for obtaining a dispersion obtained by roughly crushing raw material fish phosphorus and dispersing it in a solvent is not particularly limited. After immersing in water adjusted to pH 2.5 to 3.0 (for example, 0.1% aqueous citric acid solution) and swelling, use a homogenizer to crush and disperse. That's fine. At this time, the coarse particles of fish phosphorus obtained by crushing may have a relatively large particle size, and the resulting dispersion does not necessarily have to be uniformly dispersed.
In an embodiment in which the micronization step is performed by a wet pulverization method, the pressure at which the dispersion is jetted and collided at a high pressure is too high. Depending on other conditions such as the distance from the nozzle of the apparatus to the position of collision and the temperature of the atmosphere of the part where the collision occurs, it is preferable to set it low so as not to cause denaturation of collagen. However, if the pressure at which the dispersion liquid is ejected is too low, the shear flow generated in the ejected liquid and the impact force generated at the time of collision become insufficient, and the coarse particles cannot be sufficiently refined. The pressure at which the dispersion is ejected is preferably set in the range of 50 MPa or more.

  In the method for producing a dispersion of the present invention, it is preferable to use water-soluble collagen as a dispersion stabilizer. Thereby, the dispersibility of the fine particles in the solvent is improved, and the fine particles can be more easily and uniformly dispersed. Specifically, for example, in an embodiment in which the micronization process is performed by a dry pulverization method, when the micronized microparticles are dispersed in a solvent, the solvent may contain water-soluble collagen. In a mode in which wet pulverization is performed, water-soluble collagen is contained in water adjusted in pH as a solvent when a dispersion is obtained, or the dispersion obtained by refining coarse particles in the dispersion is used. What is necessary is just to make it contain water-soluble collagen. The water-soluble collagen that can be used as the dispersion stabilizer and the amount (content) of the water-soluble collagen are as described above in the section [Dispersion of the present invention].

Each treatment (each step) in the method for producing a dispersion of the present invention is preferably performed under a temperature condition of 15 ° C. or less as much as possible in order to suppress collagen denaturation.
[Use of dispersion according to the present invention]
The dispersion according to the present invention is a fish-derived, but can be fully denatured at a temperature near the human body temperature and can fully exhibit the original properties of collagen. It is possible to replace the collagen solution as a solution to overcome the disadvantage of low. Therefore, for example, cosmetics and quasi-drugs using the dispersion according to the present invention as a raw material or as a product are hardly denatured by body temperature even when they are attached to the skin, and the original effects of collagen ( Moisturizing properties etc. are fully exhibited.

Hereinafter, when using the dispersion concerning this invention as various cosmetics, a quasi-drug, etc., the component and additive which can be mix | blended as needed are illustrated to following (1)-(44). These components and additives can be arbitrarily selected and used in combination, and the amount of the components and additives is not particularly limited, but it is usually preferably in the range of 0.0001 to 50% by weight.
(1) Various fats and oils: avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange raffer oil, sesame oil, cacao butter, chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, cucumber nut oil, safflower Oil, shea fat, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, owl, Coconut oil, beef tallow, lard, squalene, squalane, pristane or hydrogenated products of these oils (hardened oil, etc.)

(2) waxes; beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax, rice wax and the like.
(3) Mineral oil; liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, micro-crystal wax and the like.
(4) Fatty acids: lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid, undecylenic acid, tall oil, lanolin Synthetic fatty acids such as natural fatty acids such as fatty acids, isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid and isopentanoic acid.

(5) Alcohols; synthesis of natural alcohols such as ethanol, isopropylanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, 2-hexyldecanol, isostearyl alcohol, 2-octyldodecanol, etc. alcohol.
(6) Polyhydric alcohols; ethylene oxide, ethylene glycol, diethylene glycol, triethylene glycol, ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, polyethylene glycol, propylene oxide, propylene glycol, polypropylene Glycol, 1,3-butylene glycol, pentyl glycol, glycerin, pentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, sorbitol, mannitol, lactitol, maltitol and the like.

(7) Esters: isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, hexyl decyl dimethyloctanoate, cetyl lactate, myristyl lactate Diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, and the like.
(8) Metal soaps: aluminum stearate, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate and the like.

  (9) Gum, sugars or water-soluble polymer compounds; gum arabic, benzoin rubber, dammar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum, carob gum, quinseed, agar, casein, lactose, fructose, sucrose or esters thereof , Trehalose or derivatives thereof, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, hydroxyalkyl (C2-C4) chitin or chitosan to which alkylene (C2-C4) oxide such as ethylene oxide is added, low molecular weight Chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or salt thereof, hyaluronic acid or salt thereof, chondroitin sulfate or salt thereof, heparin, ethylcellulose, methylcellulose Carboxymethyl cellulose, carboxyethyl cellulose, carboxyethyl cellulose sodium, hydroxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyethylene oxide and polypropylene oxide Such as polyalkylene oxide or a crosslinked polymer thereof, carboxyvinyl polymer, polyethyleneimine and the like.

  (10) Surfactant; anionic surfactant (alkyl carboxylate, alkyl sulfonate, alkyl sulfate ester salt, alkyl phosphate ester salt), cationic surfactant (alkyl amine salt, alkyl quaternary ammonium salt), Amphoteric surfactant: Carboxylic acid type amphoteric surfactant (amino type, betaine type), sulfate ester type amphoteric surfactant, sulfonic acid type amphoteric surfactant, phosphate ester type amphoteric surfactant, nonionic surfactant (Ether type nonionic surfactant, ether ester type nonionic surfactant, ester type nonionic surfactant, block polymer type nonionic surfactant, nitrogen-containing type nonionic surfactant), other surfactants (Natural surfactants, protein hydrolyzate derivatives, polymer surfactants, surfactants containing titanium and silicon, Carbon-based surface active agent) and the like.

  (11) Various vitamins; vitamin A group: retinol, retinal (vitamin A1), dehydroretinal (vitamin A2), carotene, lycopene (provitamin A), vitamin B group: thiamine hydrochloride, thiamine sulfate (vitamin B1) , Riboflavin (vitamin B2), pyridoxine (vitamin B6), cyanocobalamin (vitamin B12), folic acid, nicotinic acids, pantothenic acids, biotins, choline, inositols, vitamin C group: vitamin C acid or its derivatives, vitamin D group : Ergocalciferol (vitamin D2), cholecalciferol (vitamin D3), dihydrotaxosterol, vitamin E group: vitamin E or its derivatives, ubiquinones, vitamin K group: phytonadione (vitamin K1), menaquinone (vitamin K2) , Menadione (vitamin K3), menadiol (vitamin K4), other essential fatty acids (vitamin F), carnitine, ferulic acid, .gamma.-oryzanol, orotic acid, vitamin P such (rutin, eriocitrin, hesperidin), vitamin U and the like.

(12) Various amino acids: valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxy Amino acid derivatives such as lysine, arginine, ornithine, histidine, sulfates, phosphates, nitrates, citrates, or pyrrolidone carboxylic acids.
(13) Various additives derived from plant or animal raw materials; specific raw materials used as raw materials include i) to v) below.

i) As a plant (herbal medicine), for example, almond (toen), ai (blue leaf), Aokazura (Seifu Fuji), Aoki (Aoki), Aogiri or Kenashia Ogiri (Akiri), Aotsu Rafuji (wood moth), Aotenma, Acacia, Red clover (red hempen), redcurrant `` fruit '', red clover, red grape, red ginseng (logwood), red coconut wrinkle (red buds), red crested akane or capsicum or red radish (red roots), red crested or red crested radish (Aki) , Aki larch, Akinire (crusted skin), Aguay Guassu, Aguahe (Omiten coconut), Akebi (Kitsu), Asa (Asakojin), Maruba morning glory or morning glory (Check cow), Hydrangea (hydrangea), Ashitaba (Tomorrow) , Azuki (Red Azuki), Asunaro, Acerola, Asenyaku (Asen Yaku), Athira (Shokuyo Kanna), Anise, Abiu, Abiurana, Abu Rana, Abemaki `` Fruit '', Avocado, Ama, Achacha (Amacha), Achacharu, Amadokoro (Tamatake), Amana (Amberanthus), Amaranth (Amaranthus, Hagatetou, Himagatetou, Senninkoku, Sugimorigateto, Hosoaoogeito, Aogeiyu, Aogeitou Amaranthus hippochondriax), Amigasayuri or Baimo (shellfish mother), Aristolomeria (Yurizuisen), Arcana (Arkanna), Algarrobo (Cabbage), Altea, Arnica, Alpinia or Katsumadai (Suzukuku), Aloe (蘆薈), Aloe vera, Angelica, apricot or hon-anzu (Anzujin), Ansokkou (benzoic incense), yellow support, igakozolina (geo-biliary head), licorice or gecko licorice (indian octopus), rush (lightheart grass), itadori (tiger cane root), yew (first place) , Strawberry, fig (No flowers `` fruits, leaves ''), Ichihatsu (first), Ichibi (winter lion), Ichiyakusou (one medicinal herb), Ginkgo (Ginkgo `` seed, leaves ''), Itohimehagi (distant), locust bean, Inazuna (Talexiki), Inubiyu (Honagainbiyu), Rice `` Seeds, Seed coat '', Inondo `` Seeds '', Ibukiso Sou, Nettle, Iran Iran, Iwa Tobacco (Iwabuchi), Iwahiba or Iwamatsu (Maki), kidney bean, oolong tea, fennel (mustard), wheat ( (Chibusanoki), Ukiyagara (Sanryo), Uguisukagra `` Fruit '', Himewikyo, Turmeric (Golden), Duckweed (Ukibuki), Usubasaishin or Keirinsaishin or Oshusaishin (spicy), Usvenia Oy, Usbenitachaoi , Weevil (summer hay), Udo or Shishido (Kansei, independent, Tang Dynasty), Unyadegato (Unkaria, Cat's Black) -), Uba tea, Ume (Plum plum `` Seeds, Flesh ''), Vulgaris, Rumors (Kusakobomo), Satsunkankan (Chen), Unboku, Estragon, Ezoukogi (Tsumagogoka), Ezo lily of the valley, Echinashi (Hosobamurasaki Barengiku), Enishida, Enokitake (bamboo shoots), Ebisu rush or Cassia tora (Keriko), El Campre, Elderberry `` fruit '', Elemi, Elingi or pre-lotus eringe, Enju (bamboo shoots, camellia rice), Pea, Ogi or Kibanaogi ), Naruko Yuri or Kagura Mabanaru Koyuri (Yellow), Ohisasa No Yuki or Sasano Yuki, Ouren (Yo Ren), Ogata Houken, Okarasuuri (Karokon), Oguruma (Civil Incense), Otsu Rafuji (Prevention), Obaco , Hazel thistle (Zhengzhou leakage, bald eagle), toucan (lion), giant White cactus, Ovana okera or Okera (white birch), Osara bursberg (Banaba), Obayayashabushi "fruit", Steller's beetle (cereal sperm), Oia catechu, Bark hawthorn or Hawthorn (Yellow bark), Omi palm, Barley zea Serpentine), Okra `` fruit '', Oguruma (turnover), Oguri higotai (Zhengzhou leakage, indigo sashimi), Panax ginseng or Tochibaninjin (Ginseng), Hypericum pertussis or Hypericum pertussis (Little cut grass), Odrichosium (continued) ), Onamomi (Bird), Onigurumi, Onidokoro or Tokoro or Nagadokoro (Hikai), Oninoyagara (Tempa), Onyuri or Sasayuri or Hakatayuri (Yuri), Onoelan, Ononis, Halibut (Flyer), Ominaeshi ), Yuuko, Dutch mustard (watercress), Dutch jellies, Oran Davileus, Dutch honey bees, olives `` fruits, seeds, leaves '', oregano, orange `` fruits, pericarps '', silkworms (ripening yellow), cacao `` fruits, pericarps, seeds '', oysters (persimmons `` leaves ''), scallops ( (Fujitsuto), Kakidooshi or Kantorisou (Lotus herb), Kakiran, Gaku Hydrangea, Cassia, Casino oyster (fruit `` fruit ''), Gadju (Kashiwa), Kashiwa (Kashiwagi, Kashiwa), Cascarilla, Cascara Sagrada, Gypsophila, gypsophila, cynomolgus (Kinshato), kaniwa, carnation, valerian (valerian), hippopotamus, birch or fern birch (white birch), gerbera, pumpkin, kapochonoki "seed", kahokusansho (salmon), gama (salmon yellow) , Chamomile or roman chamomile, chamomile (weed), cam cam (camo duck), carraguwa or yamaguwa (mulberry moth), color, chrysanthemum man, crow cucumber or cinnaka Suri (Wang Song), Crowed Bishak (half-summer), Oats, Garana `` Seeds '', Karaho (Koh-Pak), Karaya, Garyu, Karin (Kiso), Garcinia, Kawamidori, Kawara-Psycho (Koryocho, Shirasu), Kawajisha , Kawaratake, Kawaranadeshiko (stone bamboo) or Ezokawaranadeshiko (buckwheat, buckwheat), Chinese carrot (blue potato), Chinese mugwort (茵 chen 茵), Kansui (sweet candy), licorice (licorice), Kantarasa, Kandelira, Kanto, Kanna, Orchid, raspberry (Ezo strawberry, Dutch strawberry, shrimp strawberry, nava white strawberry, maple strawberry, European raspberry), kiwi `` fruit, leaf '', kikarasuuri (guro-root), kyo-kyo (kikyo, bellflower root), chrysanthemum (chrysanthemum, zebra anteater, ginkgo biloba) ), Kikutaniku, Kisage (Kashimi), Gishigishi (Yotei), Kijitsu (Kashimi), Kizuta, Kidachi Aloe, Nigga, Kina, Kinanoki (Sincona, Red Kinaki), Kinua (Quinoa), Yellowfin, Yellowfin, Gimnema sylvestre, Kimenkaku, Cabbage, Cabbage `` Immature fruit '', Caraway, Cucumber, Gyoryu (Nishikawa willow, Tail willow) , Kiraja saponaria, Kiraya, Kiransou (golden grass), Kumquat `` fruit '', Kinkiju, Ginseikai, Kimbusen, Kinma, Kinshuhiki (Sentsukakusa), Kinran, Ginlan, Kinryohen, Guapeba Vermela, Guava `` Fruit '', Guayule, Quercus infectria, cucumber nuts, kugenumaran, wolfberry (bamboo shoots, coconut leaves, cocoon leaves, cruciform skin), squirrel katsura (Tenmon winter), kudu (kudzu), camphor, gooseberry `` fruit '', xanthines (yellow flowers)蒿), Kutiti River, Gardenia (Yamako), Kunugi (樸) C), Kupuas, Kubeba, Kumazasa, Kuma-tsutsura (horse whip grass), Clara (bitter), cranberry `` fruit '', chestnut `` seed, fruit, astringent skin '', curkurigo latifolia `` fruit '', grapefruit `` fruit and leaf '', buckthorn , Black-headed Mochi (required), Kamehiba-kokoshi or Kurobana-hikokoshi or Hiki-koshi (life-prolonging grass), Clove (clove, clove), Gumbai Tuna (cough, budgerigar), Kaigai (bamboo shoot, spikelet), Celosia (fowl crown, chicken crown), Gekkavidin, bay bay (bay laurel), kenshi sartorii rose (earthen soil, mountain return), gentian, genus shochu (old lady's grass), kemponashi (kigushi), kokishikoku, kishumikan (kouji, tachibana, oobenimikan, fukuramanta, sagakankoji, ponto Tachibana bark)), Koshinbara (moon flower), Kousui mint Kouzo `` fruit '', kocha (tea), kohone (river bone), kouhon (Tsubakimoto, Karamotomoto), Koryang, Koryokyo (Koryo), cilantro `` fruit '', Kouren (Huo Ren), Koganebana (Yellow Gon), cowberry (Etsutachibana), coconut `` fruit '', goshyu (gyu), gosho strawberry (covered bonsai), pepper (pepper), cosmos, copaiba balsam, coffee `` seed, leaves '', kobushi or magnolia (hot pepper), burdock (beef bowl, Beef eggplant), coconut mulberry, sesame seeds, sesame seeds (genus ginseng), trash beetle (gomi), sakanekazura or binankazura or matsubusa, wheat (wheat), rice or rice bran `` red rice cake, white birch '', rice oil, cola acminata `` `` Seeds '', Cola Vera `` Seeds '', Coleus Forskori, Colonyella, Koroha `` Fruits '', Colombo, Conzurango, Kombu, Konjac, Comfrey Isarum (Sisal Asa), Sai Hairan, Sakaneran (Ezosa Kanelan), Saximara bukkake or Shina button eel or Chinese ginseng (weiken), Sakura (Oshima cherry, Yamazakura, Oyamazakura, Edhigashi, Bean cherry, Miyazakura, Yoshizakura, Takazakura, Takazakura, Takazakura, Takazakura , Kanzakura `` leaves, flowers, fruits, bark (cherry bark) ''), cherries, pomegranates, Sasa, Sababaginran, Sazanka, Saojimodaka (Sawada), sweet potatoes, sugar cane, sugar beet, saffron jujube (Safflower), saffron West safflower), sapodilla, sapotea mariyo, pomelo `` fruit '', savonso, salmon berry `` fruit '', salamander (sand hemp), salamander (sand indigo sashimi), salvia (sage), sagaki (mountain mustard), sawagurumi (mountain) Walnuts) Cactus cactus, Sangre de Grado (croton), Sansikuyoso, Sanshichininjin (Ginseng ginseng), Sanshuyu (Yamazou), Salamander (Yamamuro), Sandskon (Yamazune), Shia (Karite), Cyanoki "fruit" , Shiitake mushrooms, shion (purple spider), winged bean, jikitarisu, shikunshi (messenger), perilla or blue-billed or chimmento or catamendizo (purple leaf, shiso-ko), rosewood, linden tree, red-billed spruce, syringae (ream), shimeji Hinshimeji, Shakashimeji, Hatake-shimeji, Oshiroi-shimeji, Beech-shimeji, Honjimeshi, Shirotamogitake), Shimokureen, Shimotsuke, Potato, Peonies (Shakuyaku), Shajin (Sanjin), Jasmine (Matsurika), Monaju Rhododendron, Shukukonkamiso, Shukushamitsu (sand seed, shredded sand), Juzudama Shurro “fruit”, Shunran, Zououyashi, Ginger (ginger), Zozan hydrangea (Tsuneyama), Shobu (persimmon, Sone), Suzuk “fruit”, Shirakashi “seed”, Silane (Bikkyu), Shirogaucho “seed”, White clover (Clover), white bean (chicken bone grass), white squirrels (scented squirrel), white squirrel `` flower '', shirovana lupine, shirominanten (southern tenmi), cinchona sylbula, ginkgo biloba (Rui incense flower, Rinka flower, decoction flower), cinnamon, cinnamum・ Cassia (Cinnamon), Watermelon (Sairan), Honeysuckle (Gin silver flower, Shinobu), Sorrel (Acid), Swimberry "Fruit", Star Apple, Stevia, Strawberry "Fruit", Psycho (Sugar), Sugina (Question) , Purslane (horse-toothed tendon, horse-toothed tendon), plum "fruit", sulgaran (oran), acacia Japanese pine cones, Japanese larch, Japanese lizard, Japanese walnut, Japanese hawthorn, Japanese cypress, Japanese dandelion, Japanese horse chestnut (Maronier), Japanese pear `` fruit '', Japanese yellow snow, Japanese elder (Juniper, Japanese cypress) Pine), Achillea millefol (milfoil), rose rose, scallop butterfly, mistletoe, mint hawk or wild mint (Derbium, sarcophagus), cedron (Boushuboku), mallow, hirohasenega, senega, seri, celery, senkyu (river cucumber) Senshinren (Penshinren), Sendan, Sennin Cactus, Senna `` Fruit, Leaf '', Sennin Sow (Otsuka), Senburi (Takumi), Senboku, Soka (Grass), Elephant Root, Soba Nami, Soba `` Seed '', Somer potato, Broad bean, Daio (daihuang), radish, soybeans, Daidai (orange peel, fruit), Takasago Gurihigotai (Southeast indigo sashimi), Takasaburo (Chinese lotus), Takatodai (Daisetsu), Takarabi (Kashiwaji), Dark sweet Cherry `` fruit '', hollyhock, hollyhock (thyme, perilla), tachidokoro (hikai), tachiyanagi, tamarind `` seed '', onion, ram shiba (hot pepper), taranoki `` fruit, leaf, root bark '', tarayo (large leaf winter blue, one leaf Tea, bitter tea, bitter tea), dahlia (tenjiku button), tarwi, tanukirime, tanshichiwa, tanjin (tansan), dandelion Npopo or Moukotanpopo, dammar, cherry "fruit", Imperata "fruit, roots, buds"
, Chixetsu carrot (Bamboo ginseng), Chicory, Chunky Piedra (Kidachikokankan), Tulip, Chokonostay, Datura (Artichoke), Dendrobium (Dahi), Datura (Lepidoptera), Datura (Leaf), Cho Reimaitake (clam), chorogi, tsukimiso, tsukushikaneran, tsukuritake (mushroom), tsuchiakebi, camellia, camellia, tsumekusa (lacquered cocoon grass), camellia (duck cocoon grass), tsuruzukiki (red red bean), tsurutsuchiakebi, tsurumukudami , Tsuruna (apricot apricot), tsurun carrot (four leaves ginseng), swine bean, tsubebuki, deco, teuchigurumi, duberry `` fruit '', tengusa, tencha (bamboo tea), tendaiyaku (glaze), chili (winter coconut), chili quail, chili pepper ( Panyu), Toki (Today), Tokinsengka (Marigold), Tosai Kachi, Tounabena (river cut), corn or corn hair (south cocoon hair), scotch moth (Sadako), Torindou or Kyakusen Lindou (Ryuboku), Tokusa (wood bandits), Dokdami (ten drugs), Tokon (root), Toshishi or Mamedaoshi or Eurasian quail, eucommia (bark `` bark, leaf, root ''), ash (crust), tomato, tragacanth, triacanthos `` seed '', Turkish turkey, tormentilla, dronoki, trorochai, tonka bean, nigerian berry `` fruit '', Chinese yam or yam (Yakuyaku), Nagai Kada (Butcher Bloom), Naginata Koju, Nazuna, Rapeseed, Solid bean or Vertical bean (Sword bean), Natsumikan, Jujube (Otsuchi), Naniwaibara (Golden cherry), Navena (Continued), Nameko , Peanuts (peanuts), nanten (southern berries), namban karamushi (satsuma), iois violet, nygaki (naki) ), Japanese mugwort (bitter melon), nutmeg, Kay or Nikkei or Ceylon Nikkei or Yab Nikkei (Keishi bark) or Keishi (Keishi branch), Flying tiger plover, leek (lion), elderberry (bone, fruit, flower, stem, leaf) , Garlic (large cocoon), nurde (penta), leek, nemonyki or nebu or nebi or nemlinoki or zigokubana (cheering), white thistle (large cocoon), wilt rose (fruit), nozenkazura (Lingen flower), nogateto, yarrow, noda ), Novara, Peach, Pineapple `` Fruits '', Hibiscus (Busouge, Furiinbusouge, Roselle), Hilindow, Hauchiwa, Pau Dorse, Hakamuraboshi (bone crush), Hakkayumatou, Hakusanchidori, Hakusen (white ring skin), Hakulberry `` `` Fruit '', Hakobe (breeding), Hazel (lion), Hashiridokoro (roth root), Basil, Lotus (lotus, lotus meat, lotus), Seri (Netherlands jelly), Hadakamugi, Batata, Hachiku or Madake (Bamboo bamboo), Patchouli, Hakka (Thin load, Thin load leaf), Hashamame, Hattogi (Yokuinin), Hanasuge (my mother), Banana, Hanahaku, Hanabishi (Shirishi, Shishitsuri) ), Vanilla bins, papaya, leafhopper (palm grass), pahalobobo, hub `` whole plant, stem, leaf '', paprika, leafy killer whale, clam or honey beetle (vine), hamasuge (flavored eggplant), lobster (spotted eggplant) , Hermanus (Maikai flower), Hamafuufu (beach windbreak), Hamamerisu, Palm, Rose (Rose), Balata, Balata rubber tree, Agaric (Agaric, White-faced agaric, Astragalus), Haran, Parisurus (Prunus japonicus), Parietalia, Harcanlan, Balsana Vine garlic, bitter gourd), harimille (crusted skin, cinnabar skin, cocoon leaf), barba Ko, Harindou, Handaikai (Aoi Okai), Panoki, Giant eel (dried), Higangeturinjin (party participation), Pecan nuts, Higanbana (Ishizuchi, Bujushahua), Hygurmadaria, Higotai, Hishi (Hishimi), Pistachio , Beet, Hitsuba (Ishizuchi), Hitsubei Nishida, Daisies (Daisy), Hinata Taikozuchi (cow knee), Hinoki Yodori, Hinoki, Hiba, Castor, Sunflower, Pepper, Himezu (Tempo), Himegatake (Kaori), Himematsutake , Hiromatsutake), Himemuyoran, Pimenta `` fruit '', beak, cypress, cypress `` fruit '', chickpea, lentil, belude oyster, betel oyster (bald bald eagle), loquat `` fruit, leaf, stem '', betel row (large clothes, Eggplant), Pu'er tea (putum tea), Japanese quail (southern rattan), Japanese cypress, Japanese dandelion (Japanese winter flowers, Japanese winter leaf), Fujiba Mackerel (Orchid), wisteria bean (Boiled Beans), Fujimodoki (Chrysanthemum cherry, cocoon), grapes `` fruit, pericarp, seeds, leaves '', beech, Fuyushinatsutake (Cycium Cordyceps), Brazilian elephant, Brazilian carrot, Brazilian palm, Brazilian elephant Black Palm, Blackcurrant `` Fruit '', Blackberry, Branjen, Plum `` Fruit '', Fruceraria, Blueberry (Prunus japonica), Prunes, Floral Blanca, Blonde Psyllium, Bundow (Mung Bean), Hazelnut, Loofah, Hetsukaran, Safflower ( Safflower), Henken, Belladonna, Berry `` fruit '', Persea, Pervianburg, Pereschia grandifolia, Bentilla biloba or Stingweed (scenic sky), Boysenberry `` fruit '', Bakigi or Sardine or Nendo or Hahagigi Kokia , Hosairan, Ho Prunus (Akansen, Acute pupa, Periosteum), Pouteria sapota, Pouteria lucuma, Hoshinoki, Spinach, Japanese physalis (Torone), Japanese cypress (Japanese folk magnolia, pak), bokeh (wooden moss), Hosobaabragiku (painful) Hosoba-oguruma, Hosobanaokera (蒼朮), Hosoba Kirinso (Keiten 37), Hosobabarengiku, Bodaiju (ダ イ 木), buttons (peony `` flowers, leaves, stems, bark ''), button pi (peony skin), hops, jojoba, Borage (Rurichisha), Bordeaux, Whiteberry Berry "Fruits", Hononiku (meat juju, Taigei), Honsekkok (iron skin sarcophagus, Sparrow mountain sarcophagus), Mizurutennansho (Tennansei), Maitake (maiko), Maou (Mao), maca, macadamia nuts, margaret (mokushungiku), macri (marine grass), mugwa (mulberry white bark `` bark, leaf ''), magnolia splengeri, mazaran eba, masalan Bas de Searer, Masheira de Boi, Mashua (Tama no Senhalen, Kyukon Kinlenka), Matatabi (Kiden Tendon), Matsukasa, Pine "Leaf, Bark, Root", Matta Orillo, Matsuhodo (Matsuhodo), Matico (Cordon Sillo), Mayoram (Hanahakka), Malvano Jazine (Bitter), Mulberry "Fruit", Quince, Malein (Bilaud Muzuka), Mango, Mangosteen, Manzanya (Andesca Mitsuru), Manshugurumi, Mandarin "Fruit", Mannentake (Ganoderma), pheasant (fruit `` fruit ''), Mishima Saiko (Shibahu), Mizuoobako or Mizuasagao (Ryutonakusa), Mizokakushi (half-sided lotus), Misohagi (Chinese rape), Michiyanagi or Niwayanagi (Henpo) Mitsugashi, Mitsuba, Midori Zapote, Midori Hakka, Mimosa, Ginger, Miracle Fruit "Fruit", Myrrh, Milo Balun, wheat straw, mugwort (mushroom), mugwort, mugwort (life-prolonging skin), munya, purple (purple), purple samurai, or purple corn, purple maize, purple safflower (Kunming chicken blood wisteria), megakansa opuntica, Mejijiki (benusea), Mebogi, Japanese evening primrose (Moonflower), Melaroica, Melissa, Merirot, Melon `` fruit '', Mougi mugi, Mosouchiku, Mokukirin, Moje (Pepper), Mochinoki, Mokko (wooden incense), Momijiba peach `` Leaf, Seeds, Flowers, Fruits ''), Palm, Morello Cherry `` Fruits '', Morohaya (Hemp), Yakawa Murasakiimo, Yakuchi (Yoshichi), Cornflower (Yagaragi), Yaguruma Hakka, Yacon, Yaba Santa, Yashabushi (Yakuri) ) Or Himeya Chabushi or Oobaya Chabushi "fruit, pericarp, fruit ear" , Willow, starfish (octagonal gold plate), mistletoe (willow infestation), willow (kawayanagi, tachiyanagi, weeping willow), red willow, cat willow, incoryanagi, kinu willow, kolyanagi, unryu willow, palm, yamana, yamana , Doronoki), willow tree `` leaves, stems '', jabgarashi, Yabukouji (purple gold beef), Yab tobacco (crane tsumugi, Tenmeisei), pokeweed (trade land), Yamahanoki (Yamabori), bayberry (Plum plum), bayberry, eucalyptus , Yukinoshita (tiger ear grass), yucca or flevifolia, yuzu `` fruit '', lily, crocodile, mugwort (raib), ligan (raiminmaru), lime `` fruit '', rye, lacanka `` fruit '', raspberry `` leaf, fruit '' , Latania (Clamelia), Lacchi or Shallot (Lady), Lavender, Li Ugan (dragon eyed meat), agave (Aonu agave, fukurin agave), ryokucha (green tea), apple `` fruit, seeds, leaves, roots '', gentian, lubas or suabisimus (cool), rulitama thisami (urajiro higotai, shinjiai sashimi) ), Ganoderma (ricepick, toothpick core), lettuce (chisha), red currant `` fruit '', red pitaya, lemon `` fruit '', lemongrass, forsythia or forsythia (ream), forsythia, wintersweet, wax palm, locon (Yoshi, Sone), Loganberry “fruit”, Rosemary (Mannenrou), Rosehip (Nobara), Wasabi, Watafujitsugi (Mitsumona), Waremokkou (Earth).

  ii) As seaweeds, for example, seaweed [Green algae: Chlorella vulgaris, Chlorella pyrenoidosa, Chlorella ellipsoidia, Aonori (Usubaaonori, Susiaonori, Hiraaoori, Boaoonori, Hosoeda Aonori), Anaaasa (Aosaa) Class: Kombu (Macombu, Resilibu, Hosome Kombu, Mitsuishi Kombu), Wakame, Hirome, Aowakame, Giant Kelp (Macrocystis pirifera, Macrocystis integrifolia, Neocites Luetkeana), Hijiki, Hibamata, Umiuchiwa Kirebano Miuchiwa, Akaba Miuchiwa, Kona Miuchiwa, Okinachiwa, Usukiuchiwa, Etsukimiuchiwa], seaweed [Red Algae: Hijirimen, Maxa (Tengusa), Hiraksa, Oniku , Prickly pear, cypress cypress, cypress cypress, cypress cypress, cypress cypress Shikinori, Kainori, Yareus banori, Kagius banori, Susius banori, Haius banori, Akamominori] etc.

  iii) Examples of other algae include, for example, green algae (Chlamydomonas: Chlamydomonas, Akayukimo, Dunaliella: Dunaliella, Chlorococcus, Chlorococcus: Kuwanomimo, Volboxa: Ohigemawari, Volbox, Palmera, Yotsumemo, : Hizaori, Aoumikuro, Tsurugimidoro, Hibidoro: Hibidoro, Aosa: Anaaaosa, Amiaosa, Nagaaosa, Kawanori: Kawanori, Friccella, Shiogusa , Genus Magatama: Magamata, Iwata: Fusaiwata, Surikogita, Heraiwata, Kurokita, Hanemoga, Mille: Mill, Chromel, Sakibutimiru, Naga Lem, Hiramil, Casanori: Casanori, Jusmo: Futjusmo, Tamajusmo, Mizojusmo, Mizumakimo, Korekaete, Tsutsumimo, Kikumogusa: Kikkougusa, Hitogususa: Hitohagusa, Shirohaemu Genus, Sumiremo: Sumiremo, Hosimidoro, Fuchinashimidoro, etc., Cyanobacteria (Suizenjinori: Suizinoriori, Aoko, Nenjumo: Kawatake, Ishijelly, Hasai, Yuremomo, Rasenmo (Spirulina): Spirulina, Trichodesmium (Trichodesmium) Iacacio genus), brown algae (Piraera genus: Piraela, Shiomidro genus: Nagamisiomidro, Iso grape genus: Iso grapes, Isogawara genus: Isogawara, Black moth genus: Gunsen kurogashira, Kashirazaki genus Kashirazaki, Muchimo: Muchimo, Hiramchimo, Keberigusa, Amygusa: Amygusa, Sakibiro Amiji, Sanadagusa: Sanadagusa, Fukurimamiji, Commongusa: Commongusa, Yahazugusa, Ezoyahasahusa, Ganoderma Umichiwa, Akaba Umichiwa, Nami-Makura: Hirami-makura, Somae-kegusa: Someraceae, Navarimo: Navaimo, Chasomen-genus: Otsuka-chasumen, Matsumo-genus: Matsumo, Nagamatsu-moe Genus: Futzoku, Ishimozuku: Ishimozuku, Kuromo: Kuromo, Nisemozuku: Nisemozuku, Mozuku: Mozuku, Ishigeu: Ishige Iromega, Ichimegasa: Ichimegasa, Quercus genus: Quercus, Cyprinus: Cyprinus, Urushigusa: Urushigusa, Keurushigusa, Tobacco prunus, Crested genus: Combina, Haberodoki: Haberodoki, Habanori, Habori : Common Bukuro, Ezobukuro: Ezobukuro, Fukuronori: Fukuronori, Cotton, Chishima Fukuronori: Chishima Fukuronori, Kagomenori: Kagomenori, Muraridori: Murachidori, Shazugusa: Shazugusa, Yojiri Flounder, genus genus: genus genus, genus cirrus: genus cirrus, genus turtle: shark, genus squirrel: genus sujime, misjikonbu: misjikonbu Genus: moths, oyster combs, onicombu, gohei konbu, nagakonbu, peas, prunus, trollocomb: trorocombs, antokume: antokume, kajime genus: kajime, tsuruarame, kurome, kikushikonbu genus Genus: Kuroshiome, Nekoashikonbu, Nekoashikonbu, Arame: Alame, Ainuwakame: Ainuwakame, Chigaiso, Oniwakae Ezoushige: Ezoishige, Yabamoku Honda Walla: Tamanashimoku, Isomoku, Nagashimamoku, Akamoku, Shidamoku, Honda Walla, Nejimoku, Narasamo, Mametawala, Tatsukuri, Yatsumatamok, U Toranoo, Obamoku, Fusushimoku, Hahamoku, Togemoku, Yoremok, Sawtooth Moku, Obatokorimok, Sugimoku: Sugimoku, Ukimo: Oukimo, Buruomomo: Ukiburi, Ushiburi Genus: Asakusa Nori, Susabinori, Uppuri Nori, Onimanori, Tasa, Firitasa, Benitasa, Rhodocorton: Milnobeni, Akebonomozuku: Akebonomozuku, Konahadama: Hikonahadam, Yogore-no-Hana, Aomi-nosam Benimozuku, Hosobenimosk, Pinus genus: Pinus pine, Fusanori: Fusanori, Nisefusanori: Nisefusanori, Sodegarami: Sodegarami Rattlera: Rattle, Rattle, Hirohata Tadaki: Hiroha Taitaki, Tamai Tadaki: Tamaitaki, Kachinori, Kachinori, Kaikekenori, Proboscis: Himetengusa, Hytengusa, Hida , Rhizome genus: Rhizome genus, Rhimon genus: Ryumonsou, Hera Ryumon, Nisekarekigusa, Nisekarekigusa, Okitsubara genus: Oobaokokibara, Akaba , Shiogusagoromo: Shiogusagoromo, Iwanokawa: Etsukiiwakawa, Kainokawa: Kainokawa, Kaninote Canninote, Coral spider: Coral spider, Centipede sp. Matabou, Kintoki: Chabokintoki, Kintoki, Matsunori, Kori nori, Tosakamatsu, Hitomimatsu, Fusikintoki, Tsunomukade, Nagakintoki, Sugimukade, Kakrateto: Oobakintoki, Atomugi, Atocho, Toshiro , Genus genus: cricket, genus genus: squirrel mosquito, broad-skinned swordfish, squirrel scorpion, black saka Prunus, Nezano Sasamodoki, Yusora, Etsukinosakamodoki, Nankai Sakamodoki, Himetosakamodoki, Kinu Hada: Kinu Hada, Ezo Tosaka Genus: Ezo Tosaka, Tsukasano Geni: Enashikarimenia, Otsukasarihi, Hana : Chrysanthemum, Usuginu, Nikuhounoo: Nikuhounoo, Venusnago: Venusnago, Suscabeni: Suscabeni, Okaragusa: Porcupine, Mirrin: Mirin, Hosobamirin, Tosakanori: Isotari, Ezocari, Ezocari Yukari, Hosoyukari, Ibaranori: Ibaranori, Saidaibara, Tachiibara, Kagiibaranori, Kizinomo: Kizinoo, Isodantsu: Isodantsu, Atsubanori The genus Azobanori, Ogori-no-Gori, Ogonori, Tsurushiramo, Shiramo, Oogo-nori, Mizo-okonori, Kabanori, Beniogonori, Fukureshinori, Purple birch, Shinkabanori, Togebanori, Katagogori, Ryukyugogori , Genus moth, genus beetle, genus moth, genus fuchklenori, genus moth, genus moth, genus moth, genus genus: genus genus , Hosobonori, Novonori, Black-headed Ginkgo: Black-headed Ginkgo, Red-backed Ginkgo: Red-backed Ginkgo Genus: Hoshibukuro, Madaragusa: Togemadara, Etukimadara, Taoyagisou: Taoyagisou, Hanasakura, Otsunogi: Otsunogi, Suikokonori, Hananoeda: Hananoeda, Hiratakayagi, Buddha, Dasu Fuchunori: Benifukuronori, Fusutunagi: Fusutunagi, Himefushitsugi, Hirohafushitsugi, Otsunagisou: Hirawatsugisou, Usuwawatsunagiso, Igisu: Genius, Keigis, Harigis, Hanaegi Crimson genus: Bromeliaceae, Convolvulaceae: Habutaenori, Conohanori, Suzuronori, Usbeni: Usbeni, Hasujiginu: Hasujiginu, Nagakonoh Nori: Nagakonohanori, Sugiginu: Sugiginu, Atsubasjiginu, Heiusbanori: Kagiosbanori, Yareusbanori, Susiusbanori, Haiusbanori, Usubarimodoki: Genus, Ayanisiki Isohagi, Shimadadia, Dajimodoki: Daijimodoki, Engussa: Moroitogusa, Fuyugusa, Makuri: Makri, Willow-nosed: Hanayanagi, Yuna, Yanagiri, Motsureyuna, Venetiancoly, Mosayanoso, Sahayazonoso, Hanazozo Genus: Hanegusa, Kehanegusa, Kozanemo genus: Kozanemo, Isomurasaki, Hosozozanemo, Himegoke: Himegoke, Kuromegoke, Hyodosigki: Kikuhi Doshi, Hyodosigusa, Usubahiodoshi, Isomegusa: Isomegususa, Suginasushigusa: Susujinashigusa, Isobashousu: Isobasho, Fujimatsumo: Fujimatsumo, Sawweed: Genus Hawk , Genus Ochimo, genus Oki, genus chinensis, genus chinnomo, genus chinsino, genus chinsino, etc. ), Yellow algae (Hikarimo genus: Hikarimo, etc.) and the like.

  iv) As raw materials derived from animal raw materials, chicken crown extract, cow or pig, human placenta extract, cow or pig stomach, duodenum, intestine, spleen extract or decomposition product thereof, cow or pig brain tissue Extract, cattle / pig collagen hydrolyzate (acid, alkali, enzyme, etc.) degradation product, water-soluble collagen or collagen derivatives such as acylated collagen, cattle / pig elastin or elastin hydrolyzate (acid, alkali, enzyme, etc.) Or water-soluble elastin derivative, keratin and its degradation product or their derivatives, silk protein and its degradation product or their derivatives, pig or cow blood cell protein degradation product (globin peptide), cow or pig hemoglobin degradation product (hemin, Hematin, heme, protoheme, heme iron, etc.), milk, casein and its degradation products or their derivatives, skim milk powder and their degradation products or their derivatives, Feline or a degradation product thereof, egg ingredients, fish hydrolyzate, nucleic acid-related substance (ribonucleic acid, deoxyribonucleic acid), or the like.

v) Arbitrary sites, cells, tissues, organs, metabolites, etc. derived from genetically modified organisms or cell fusions of materials derived from plant or animal materials. Furthermore, for example, an undifferentiated cell group or a cell group in the middle of differentiation, etc. obtained by culturing cells of an arbitrary site, cell, tissue, organ or the like.
These various additives derived from plant or animal raw materials are processed in a conventional manner according to the product type and form to be added (for example, pulverization, milling, washing, hydrolysis, fermentation, purification, pressing, Extraction, fractionation, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. are arbitrarily selected and combined), and selected from various materials. It ’s fine.
The solvent used for extraction may be selected in consideration of the intended purpose and type of the product to be provided or the processing to be performed later. Usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol , 1 type selected from various organic solvents such as lower alcohols such as isobutanol or hydrous lower alcohols, polyhydric alcohols such as propylene glycol, 1,3-butylene glycol and glycerin or hydrous polyhydric alcohols, acetone and ethyl acetate Alternatively, it is desirable to use a mixture of two or more. However, when it is not preferable to contain an organic solvent depending on the application, it is sufficient to use only water or ethanol that can be easily removed after extraction, and it may be used alone or in any mixture with water. The thing extracted and extracted may be sufficient.

  (14) Marine components; seawater such as deep seawater, eg, sea salt, dried seawater, dead sea or Atlantic or Pacific seawater (sodium chloride, magnesium chloride, potassium chloride, etc.), sea mud or Mud (Fango), for example, sea mud or mud from various locations such as Italian Fango, German Fango, Eifel Fango, Freiburg Fango (Contained components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, manganese oxide, sodium oxide, oxidation Potassium, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), saintoku stone, black meteorite, etc.

(15) Microbial culture metabolites; yeast metabolites, yeast extract, bacterial metabolites, bacterial extract, mold or actinomycete metabolites, mold or actinomyces extract, natto metabolites, natto extract, rice fermentation Extract, rice bran (red rice bran, white rice bran) fermented extract, Euglena extract or decomposition product thereof or water-soluble derivative thereof, trehalose or derivative thereof, lactic acid fermentation product of raw milk or skim milk powder, lactic acid bacteria fermentation product of legumes, coconut palm plant Lactic acid bacteria fermented products.
(16) α-hydroxy acids; glycolic acid, citric acid, malic acid, tartaric acid, lactic acid and the like.
(17) Inorganic pigments: silicic anhydride, magnesium silicate, talc, kaolin, bentonite, mica, mica titanium, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide , Bengala, black iron oxide, Gunjo, chromium oxide, chromium hydroxide, carbon black, calamine, etc.

  (18) UV absorber / blocker; benzophenone derivative (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid sodium, Dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone-sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), paraaminobenzoic acid derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate) Octyl paradimethylaminobenzoate), methoxycinnamate derivatives (ethyl paramethoxycinnamate, isopropyl paramethoxycinnamate, paramethoxycinnamon) Octyl, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate, diparamethoxycinnamate mono-2-ethylhexanoate glyceryl, etc.), salicylic acid derivatives (octyl salicylate, phenyl salicylate, homomenthyl salicylate, dipropylene glycol salicylate) , Ethylene glycol salicylate, myristyl salicylate, methyl salicylate, etc.), anthranilic acid derivatives (such as methyl anthranilate), urocanic acid derivatives (urocanic acid, ethyl urocanate etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, Imidazoline derivatives, pyrimidine derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, alane In derivatives, nicotinic acid derivatives, vitamin B6 derivatives, umbelliferone, esculin, benzyl cinnamate, cinoxalate, oxybenzone, dioxybenzone, octabenzone, soribenzone, benzoresorcinol, arbutin, guaiazulene, shikonin, baicalin, baicalein, berberine, neoheliopan, Escalol, zinc oxide, talc, kaolin, etc.

  (19) Whitening agent; paraaminobenzoic acid derivative, salicylic acid derivative, anthranilic acid derivative, coumarin derivative, amino acid compound, benzotriazole derivative, tetrazole derivative, imidazoline derivative, pyrimidine derivative, dioxane derivative, camphor derivative, furan derivative, pyrone derivative , Nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, vitamin C or derivatives thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), vitamin E or derivatives thereof, kojic acid or derivatives thereof, oxybenzone, benzophenone, arbutin, guaiazulene , Shikonin, baicalin, baicalein, berberine, placenta extract, ellagic acid, lucinol, etc.

  (20) Tyrosinase activity inhibitor; vitamin C or a derivative thereof (vitamin C phosphate magnesium salt, vitamin C glucoside, etc.), hydroquinone or a derivative thereof (hydroquinone benzyl ether, etc.), kojic acid or a derivative thereof, vitamin E or a derivative thereof , N-acetyltyrosine or its derivatives, glutathione, hydrogen peroxide, zinc peroxide, placenta extract, ellagic acid, arbutin, lucinol, silk extract, plant extract (camille, mulberry, gardenia, toki, bittersweet, clara, mugwort, Honeysuckle, Yellowfin, Butterflies, Pinewood, Barley, Oyster Saw, Hops, Hawthorn, Eucalyptus, Achillea millefolium, Altea, Keihi, Mankeishi, Hamamelis, Karaguwa or Yamaguwa, Lifelong Grass, Kikyo, Toshishi, Jyogo, Ibuki, Mao Sinensis, Dokkatsu, Psycho, storm, littoralis, Scutellaria, peony bark, peony, cranesbill, kudzu root, licorice, Fushi aloe, Cimicifuga, safflower, green tea, black tea, Ali elixir), and the like.

(21) Melanin pigment reduction / decomposition substance; phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide, zinc peroxide, hydroquinone or its derivative (hydroquinone benzyl ether).
(22) Turnover promoting action / cell activator: hydroquinone, lactic acid bacteria extract, placenta extract, ganoderma extract, vitamin A, vitamin E, allantoin, spleen extract, thymus extract, yeast extract, fermented milk extract, plant extract (aloe , Ogon, Horsetail, Gentiana, Burdock, Sicon, Carrot, Clam, Hop, Yokuinin, Odori, Semburi, Toki, Tokinsenka, Achacha, Hypericum, Cucumber, Tachikaku, Mannenrou, Parsley).

(23) Astringent: succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc paraphenol sulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannic acid (including catechin compound) and the like.
(24) Active oxygen scavenger; SOD, catalase, glutathione peroxidase and the like.
(25) Antioxidant: Vitamin C or a salt thereof, stearic acid ester, vitamin E or a derivative thereof, nordihydrogua ceretenoic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxy Anisole, propyl gallate, sesamol, sesamorin, gossypol, propolis, etc.

(26) Lipid peroxide production inhibitor: β-carotene, plant extract (sesame culture cell, hamcha, hypericum, clams, clove, melissa, birch, birch, salvia, mannenro, minamitenji, agetsu, ginkgo, green tea) and the like.
(27) Anti-inflammatory agent: ictamol, indomethacin, kaolin, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, diphenhydramine hydrochloride, d-camphor, dl-camphor, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, glycyrrhizic acid or Its salt, glycyrrhetinic acid or its salt, licorice extract, coconut extract, age extract, propolis, etc.

  (28) Antibacterial / bactericidal / disinfectant: Acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or hydrolyzate thereof, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, chloramine T , Salicy powder, iodine compound, iodoform, sorbic acid or salt thereof, propionic acid or salt thereof, salicylic acid, dehydroacetic acid, parahydroxybenzoic acid esters, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol, thymol, phenethyl alcohol, o-phenylphenol, Irgasan CH3565, halocarban, hexachloroph , Chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, ethylene glycol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, chlorobutanol, isopropylmethylphenol, nonionic surfactant (polyoxy Ethylene lauryl ether, polyoxyethylene nonyl phenyl ether, polyoxyethylene octyl phenyl ether, etc.) amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactant (cetyltrimethylammonium bromide) Benzalkonium chloride, benzethonium chloride, methyl rosaniline chloride), formaldehyde, hexamine, brilliant green, ma Kite Green, Crystal Violet, Jamaru photosensitive No. 101-containing, photosensitizer No. 201, photosensitizer No. 401, N- long chain acyl basic amino acid derivative and its acid shark salts, zinc oxide, hinokitiol, Sophora root, propolis, and the like.

  (29) Moisturizer; glycerin, propylene glycol, 1,3-butylene glycol, polyethylene glycol, glycerin tricaprycapric acid, glycolic acid (α-hydroxy acid), hyaluronic acid or its salt, chondroitin sulfate or its salt, water-soluble chitin Or derivatives thereof or chitosan derivatives, pyrrolidone carboxylic acid or salts thereof, sodium lactate, urea, sorbitol, amino acids or derivatives thereof (valine, leucine, isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, Serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glutamic acid, hydroxylysine, arginine, ornithine, histidine, Sulfates, phosphates, nitrates, citrates, or pyrrolidone carboxylic acids), fats and oils “Avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange rafa oil, sesame oil, cocoa butter, Chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, quince seed oil, cucumber nut oil, safflower oil, shea fat, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed oil, jojoba oil, persic oil, castor oil , Sunflower oil, cottonseed oil, peanut oil, turtle oil, tea tree oil, mink oil, egg yolk oil, palm oil, palm kernel oil, molasses, coconut oil, eucalyptus oil, beef tallow, pork fat, squalene, squalane, pristane or these oils and fats Hydrogenated products (hardened oil) ", waxes (bee wax, carnauba wax, whale wax, lanolin, liquid lano Phosphorus, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax, rice wax), mineral oil (liquid paraffin, petrolatum, paraffin, ozokelide, ceresin, microcristan wax), natto bacteria metabolites, natto extract, silk fiber extract , Plant extracts (red pine sap, aloe, kudzu, chamomile, licorice, cucumber, licorice, rice or rice bran, purple root, birch or white birch sap, assembly, mulberry white skin, birch leaf, loofah, peony skin, persimmon) and the like.

(30) Elastase activity inhibitor; diisopropyl fluorophosphate, plant extract (Ogon, Hypericum, Clara, Mulberry leaf, Keihi, Genso pepper, Comfrey, Salvia, Elderberry, Bodaige, Buttonpi), seaweed extract and the like.
(31) Hair preparation; selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, castari tincture, pepper tincture, pepper tincture, quinine hydrochloride, strong ammonia water, potassium bromate, sodium bromate, Thioglycolic acid and the like.
(32) Antiandrogens; follicular hormones (estrone, estradiol, ethinyl estradiol, etc.), isoflavones, oxendrone, etc.

(33) Peripheral vascular blood flow promoters: vitamin E or derivatives thereof, assembly extract, garlic extract, carrot extract, aloe extract, gentian extract, toki extract, cephalanthin, carpronium chloride, minoxidil and the like.
(34) Stimulants: chili pepper tincture, nonyl acid vanillamide, cantalis tincture, ginger tincture, peppermint oil, l-menthol, camphor, benzyl nicotinate and the like.
(35) Metabolic active agent: Photosensitive element 301, hinokitiol, pantothenic acid or derivatives thereof, allantoin, placenta extract, biotin, pentadecanoic acid glyceride and the like.
(36) Antiseborrheic agent; pyridoxine or a derivative thereof, sulfur, vitamin B6 and the like.

(37) Keratolytic agent; resorcin, salicylic acid, lactic acid, urea and the like.
(38) Oxidizing agent; hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, sodium pyrophosphate Sodium orthophosphate, sodium silicate hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, etc.
(39) Hair remover; inorganic reducing agent such as strontium sulfate, sodium sulfide, barium sulfide, calcium sulfide, thioglycolic acid or salts thereof (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, thioglycolic acid) Magnesium, strontium thioglycolate) and the like.

(40) Hair swelling agent; ethanolamine, urea, guanidine and the like.
(41) Dye agent; 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3′-iminodiphenol, hydrochloric acid 2,4-diaminophenoxyethanol, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, orthoamino Phenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine, nitroparaphenylene Diamine, para-ami Phenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, picramic acid, sodium picramate, N, N′-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5 -(2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorcresol sulfate, 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate , Orthochloroparaphenylenediamine sulfate, 4,4′-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, nitroparaphenylenediamine sulfate, paraaminophenol sulfate, parasulfate sulfate Nitroorthophenylenediamine, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine, α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, Resorcin, tannic acid, 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzene-5'-sodium sulfonate, hematein and the like.

  (42) Fragrances: Natural animal fragrances such as musk, civet, castorium, ambergris, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, guayakwood essential oil , Cumin essential oil, black letter essential oil, cinnamon essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam essential oil, coriandel essential oil, perilla essential oil, cedarwood essential oil, citronella essential oil, jasmine essential oil, gingergrass essential oil, cedar essential oil, spearmint essential oil, western peppermint essential oil , Otsuka perfume essential oil, tuberose essential oil, clove essential oil, orange flower essential oil, winter green essential oil, trout balsam essential oil, buttery essential oil, rose essential oil, palmarosa essential oil, persimmon essential oil, hiba essential oil, sandalwood essential oil, petitgren essential oil, bay essential oil, vetiva essential oil, Bergamo Essential oil, peruvian balsam essential oil, boad rose essential oil, melamine essential oil, mandarin essential oil, eucalyptus essential oil, lime essential oil, lavender essential oil, linaloe essential oil, lemongrass essential oil, lemon essential oil, rosemary (mannen wax) essential oil, Japanese mint mint essential oil, etc. Sexual fragrance, other synthetic fragrances, etc.

(43) Dye / colorant: red cabbage dye, red rice dye, red dye, anato dye, squid dye, turmeric dye, enju dye, krill dye, carp dye, caramel, gold, silver, gardenia dye, corn dye, onion Pigment, tamarind dye, spirulina dye, buckwheat whole plant dye, cherry dye, laver dye, hibiscus dye, grape juice dye, marigold dye, purple potato dye, purple yam dye, lac dye, rutin etc.
(44) Others: Hormones, sequestering agents, pH adjusters, chelating agents, antiseptic / antibacterial agents, cooling agents, stabilizers, emulsifiers, animal / plant proteins and their degradation products, animals / plants Saccharides and their degradation products, animal and plant glycoproteins and their degradation products, blood flow promoters, anti-inflammatory agents, anti-inflammatory agents, anti-allergic agents, wound treatment agents, foam enhancers, thickeners, enzymes, purified water ( Electronic water, small clusters, etc.), oral preparations, deodorants / deodorants, bitters, seasonings, etc.

  In addition, when the additive derived from the plant or animal material of (13) and the deep sea water of (14) are used for systemic or topical external preparations and cosmetics, the protection of skin and hair is started. , Moisturizing, improving touch and texture, imparting flexibility, reducing irritation, reducing stress due to aroma, cell activation (preventing cell aging), suppressing inflammation, improving skin and hair quality, preventing rough skin and improving it, In addition to cosmetic effects such as hair growth, hair growth, hair loss prevention, gloss imparting, cleansing effect, fatigue relief, blood flow promotion, warm bath effect, etc., anticipation, deodorization, thickening, antiseptic, buffering, etc. are also expected it can.

Hereinafter, the present invention will be described more specifically with reference to Examples and Comparative Examples, but the present invention is not limited to these. Hereinafter, unless otherwise specified, “parts” indicates “parts by weight” and “%” indicates “% by weight”.
[Example 1]
4 kg of fish phosphorus sampled from cypress was degreased by stirring in 12 kg of ethanol for 24 hours, and then deashed by stirring in 12 kg of hydrochloric acid aqueous solution (pH 2.2) for 24 hours to give an ash content of 0.53% Fish phosphorus with a fat content of 0.08% was obtained. Subsequently, 2.4 kg of the fish phosphorus was dried at 60 ° C. so that the water content was 5%, and then coarsely pulverized using a cutter mill to obtain a coarsely pulverized dried fish phosphorus.

Next, 0.48 kg of the coarsely pulverized dried fish phosphorus obtained was refined with a dry pulverizer (“Tornado Mill” manufactured by Nikkiso Co., Ltd.), and then classified into particles having a particle diameter of 20 μm or less. 0.24 kg was obtained. Next, 0.24 kg of the fine particles were dispersed in 40 kg of water using a homogenizer (“TK Homomixer Mark II” manufactured by Tokushu Kika Co., Ltd.) under conditions of 6500 rpm × 5 minutes to obtain a dispersion.
[Example 2]
A coarse pulverized product of dried fish phosphorus was obtained in the same manner as in Example 1, and 0.3 kg of the obtained coarsely pulverized product of dried fish phosphorus was immersed in 50 kg of a 0.1% aqueous citric acid solution (pH 2.8) for 24 hours. And then pulverized and dispersed using a homogenizer (“TK Homomixer Mark II” manufactured by Tokushu Kika Co., Ltd.) under conditions of 6500 rpm × 30 minutes to obtain a dispersion containing coarse fish phosphorus particles. . Subsequently, the process of ejecting and colliding the dispersion liquid is performed at 100 MPa using a high-pressure injection processing apparatus (“Ultimizer System” manufactured by Sugino Machine Co., Ltd.), whereby the coarse particles in the dispersion liquid have a particle diameter of 50 μm. A fine dispersion was obtained below.

Example 3
In the same manner as in Example 1, a coarse pulverized product of dried fish phosphorus was obtained, and 0.5 kg of the coarsely pulverized dried fish phosphorus obtained was immersed in 25 kg of a 0.1% aqueous citric acid solution (pH 2.8) for 24 hours. And then pulverized and dispersed using a homogenizer (“TK Homomixer Mark II” manufactured by Tokushu Kika Co., Ltd.) under the condition of 6500 rpm × 60 minutes to obtain a dispersion containing coarse fish phosphorus particles. . Next, 5 g of pepsin was added to the dispersion, and the mixture was reacted for 48 hours while stirring with a stirrer. After the enzyme treatment, the supernatant was recovered, and the resulting supernatant was neutralized to precipitate soluble collagen. This operation was repeated three times, and 15 kg of purified collagen fiber containing 2% water-soluble collagen was recovered. Next, 5 kg of the obtained purified collagen fiber was dissolved in 50 kg of citrate buffer (pH 4.1) to obtain a 0.2% water-soluble collagen solution.

Next, 0.6 kg of fish phosphorus fine particles classified to a particle diameter of 20 μm or less obtained in the same manner as in Example 1 was added to 10 kg of the water-soluble collagen solution, and a homogenizer (specialized machinery company under the condition of 6500 rpm × 5 minutes) was added. Dispersion was obtained using “TK Homomixer Mark II”).
[Comparative Example 1]
In the same manner as in Example 1, a coarse pulverized product of dried fish phosphorus was obtained, and 0.5 kg of the coarsely pulverized dried fish phosphorus obtained was immersed in 25 kg of a 0.1% aqueous citric acid solution (pH 2.8) for 24 hours. And then pulverized and dispersed using a homogenizer (“TK Homomixer Mark II” manufactured by Tokushu Kika Co., Ltd.) under the condition of 6500 rpm × 60 minutes to obtain a dispersion containing coarse fish phosphorus particles. . Next, 5 g of pepsin was added to the dispersion, and the mixture was reacted for 48 hours while stirring with a stirrer. After the enzyme treatment, the supernatant was recovered, and the resulting supernatant was neutralized to precipitate soluble collagen. This operation was repeated three times, and 15 kg of purified collagen fiber containing 2% water-soluble collagen was recovered. Next, the obtained purified collagen fiber was dissolved in 50 kg of citrate buffer (pH 4.1) to obtain a 0.6% water-soluble collagen solution (collagen aqueous solution).

About the dispersion obtained in the above Examples 1-3 and the aqueous solution obtained in the above Comparative Example 1, the degree of modification at 4 ° C. and 40 ° C. was evaluated by moisture retention. That is, the dispersion obtained in Examples 1 to 3 and the aqueous solution obtained in the above Comparative Example 1 were each divided into two parts, one was allowed to stand at 4 ° C. for 30 minutes, and the other was allowed to stand at 40 ° C. for 30 minutes. Thus, each sample was obtained, and the moisture retention rate was determined as follows. The results are shown in Table 1.
<Moisture retention measurement method>
The filter paper (“Quantitative Ashless 6” manufactured by ADVANCE, 55 mm) was dried at 100 ° C. for 1 hour, and the weight (X) of the filter paper at this time was measured. Immediately after impregnating the filter paper with 200 μL of the sample, the weight (Y) of the filter paper at this time was measured. Subsequently, the filter paper soaked with this sample was sandwiched between clips and hung in the air, left in a windless environment at a temperature of 25 ° C. and a humidity of 60% for 50 minutes, and the weight (Z) of the filter paper was measured. . And the moisture retention was calculated | required according to the following formula using filter paper weight (X) obtained as mentioned above, (Y), and (Z). Moreover, the moisture retention rate was similarly calculated | required also about the filter paper which soaked 200 microliters distilled water instead of the sample as a blank. The results are shown in Table 1.

  Moisture retention (%) = [Z (g) -X (g)] / [Y (g) -X (g)] × 100

From the results of Table 1, the dispersions of the present invention of Examples 1 to 3 can retain a water retention of 27% or more even when left at 40 ° C. for 30 minutes, whereas the collagen of Comparative Example 1 It was found that when the aqueous solution was allowed to stand at 40 ° C. for 30 minutes, the water retention rate dropped to 17%, which was almost the same as that of the blank. From this, it can be said that the dispersion of the present invention can exhibit the intrinsic properties (water retention) of collagen even at a temperature near the human body temperature.
[Reference example]
Below, the formulation example in the case of using the dispersion of this invention for a various use is shown. In addition, the collagen dispersion in each prescription example is a combination of any one or more of the dispersions obtained in Examples 1 to 3. In addition, each numerical value indicating the blending ratio is expressed by weight%.

(Formulation Example 1) Emulsion
1. Squalane 8.0
2. Jojoba oil 7.0
3.Cetyl alcohol 1.5
4.Glycerin monostearate 2.0
5.Polyoxyethylene (20) cetyl ether 3.0
6. Polyoxyethylene (20) soorbitan monooleate 2.0
7.1,3-Butylene glycol 1.0
8.Glycerin 2.0
9.Collagen dispersion 10.0
10. Preservative (paraoxybenzoic acid ester) appropriate amount
11. Purified water Residue when the total amount of each component is 100 (Formulation Example 2) Emulsion
1. Squalane 8.0
2. Jojoba oil 7.0
3.Glyceryl paraaminobenzoate 1.0
4.ethyl urocanate 1.0
5. Vitamin C phosphate magnesium salt 1.0
6.Cetyl alcohol 1.5
7. Glycerin monostearate 2.0
8.Polyoxyethylene (20) cetyl ether 3.0
9.Polyoxyethylene (20) soorbitan monooleate 2.0
10.1,3-Butylene glycol 1.0
11.Glycerin 2.0
12.Collagen dispersion 3.0
13. Preservative (paraoxybenzoic acid ester) appropriate amount
14. Purified water Residue when the total amount of each component is 100 (Formulation Example 3) Lotion
1.Collagen dispersion 20.0
2. Hyaluronic acid or chondroitin sulfate solution 5.0
3. Perfume (lemon water) appropriate amount
4. Preservative (phenoxyethanol) appropriate amount
5. Purified water or deep sea water Residue when the total amount of each component is 100 (Formulation example 4) Cosmetic oil
1.liquid paraffin 30.0
2.Squalane 20.0
3.Olive oil 20.0
4.Isopropyl palmitate 10.0
5. Umiuchiwa hot water extract 2.0
6. Tengusa hot water extract 2.0
7. Crepefruit hot water extract 1.0
8.Olive oil 1.0
9. Shea fat 1.0
10.Butylhydroxyanisole 0.1
11. Vitamin E derivative 0.1
12.Collagen dispersion 10.0
13. Preservative (benzalkonium chloride) appropriate amount
14. Fragrance (mushroom water) appropriate amount
15. Purified water Residue when the total amount of each component is 100 (Formulation Example 5) Flexible lotion
1.Glycerin 5.0
2.1,3-Butylene glycol 5.0
3.Polyoxyethylene sorbitan monolaurate (20E.O) 1.0
4.Ethanol 15.0
5. Hibamata 50% ethanol extract 1.0
6.Suginori 50% ethanol extract 1.0
7.Laurel 50% ethanol extract 1.0
8. Kizuta 50% ethanol extract 1.0
9.Collagen dispersion 10.0
10. Appropriate amount of antibacterial / preservative (lactoferrin solution)
11. Fragrance (Western light water) appropriate amount
12. Purified water Residue when the total amount of each component is 100 (Formulation Example 6) Astringent lotion
1.Sorbit 2.0
2. POE (20) oleyl alcohol 1.0
3.Ethanol 15.0
4.Hijiki 50% 1,3-butylene glycol extract 2.0
5. Hijirimene 50% 1,3-butylene glycol extract 2.0
6. Tengusa 50% 1,3-butylene glycol extract 2.0
7. Green tea 50% ethanol extract 1.0
8. Hamelis 50% ethanol extract 1.0
9.Allantoin 0.2
10. Astringent (Zinc Sulfocolate) 0.2
11.Collagen dispersion 10.0
12. Antibacterial / preservative (thiamin lauryl sulfate) appropriate amount
13. Perfume (lavender water) appropriate amount
14. Purified water Residue when the total amount of each component is 100 (Prescription Example 7) Two-layer lotion (liquid to liquid type)
1. Squalane 8.0
2. POE sorbitan tetraoleate 0.3
3.Sorbit 1.0
4.Ethanol 15.0
5.Comb 30% ethanol extract 2.0
6. Kirinsai 30% ethanol extract 2.0
7. Senkyu 30% ethanol extract 2.0
8. Mallow 30% ethanol extract 2.0
9. Clematis 30% ethanol extract 1.0
10. Pomelo fruit 30% ethanol extract 1.0
11.Collagen dispersion 10.0
12.Ascorbic acid 0.2
13. Astringent (calamine) 0.1
14. Preservative (phenoxyethanol) appropriate amount
15. Perfume (lemon water) appropriate amount
16. Purified water Residue when the total amount of each component is 100 (Formulation Example 8) Carmine lotion (liquid to solid)
1.Glycerin 3.0
2.1,3-Butylene glycol 5.0
3.Ethanol 15.0
4. Iron oxide (Bengara) 0.2
5.Zinc oxide 0.5
6.Kaolin 2.0
7. Renilla 50% propylene glycol extract 1.0
8. Hijirimen 50% propylene glycol extract 1.0
9. Bitter 50% propylene glycol extract 1.0
10. Placenta extract 1.0
11.Collagen dispersion 10.0
12.Camphor 0.2
13.Phenol 0.03
14. Preservative (photosensitive element 201 & 401), appropriate amount
15. Fragrance (Bodhi Tree Water) Appropriate amount
16. Purified water The remaining amount when the total amount of each component is 100 (Formulation Example 9) Pack
1.Polyvinyl alcohol 15.0
2.Carboxymethylcellulose sodium 5.0
3.Propylene glycol 3.0
4.Ethanol 10.0
5. Aonori 50% ethanol extract 1.0
6. Kotojitsu no Mata 50% ethanol extract 1.0
7. Sakuraba 50% ethanol extract 1.0
8. Peach leaf 50% ethanol extract 1.0
9. odoris 50% ethanol extract 1.0
10.Collagen dispersion 10.0
11. Preservative (paraoxybenzoic acid ester) appropriate amount
12. Perfume (today water) appropriate amount
13. Purified water Residue when the total amount of each component is 100 (Formulation Example 10) Peel-off pack
1.Glycerin 5.0
2.Propylene glycol 4.0
3.Polyvinyl alcohol 15.0
4.Ethanol 8.0
5.Polyoxyethylene glycol 1.0
6. Pantothenyl ethyl ether 1.0
7. Anaaaosa hot water extract 3.0
8. Hijirimen 30% ethanol extract 1.0
9. Capsicum 30% ethanol extract 1.0
10. Ethanol 30% ethanol extract 1.0
11. Arnica 30% ethanol extract 1.0
12.Collagen dispersion 10.0
13. Preservative (paraoxybenzoic acid ester) appropriate amount
14. Fragrance (Makihasui) appropriate amount
15. Purified water Residue when the total amount of each component is 100 (Formulation Example 11) Cold cream
1. Sarah Beeswax 11.0
2.liquid paraffin 22.0
3.Lanoline 10.0
4.Olive oil 5.0
5. Chamomile oil 5.0
6. Palm oil 5.0
7.borax 0.5
8. Kotojitsu no Mata Extract 2.0
(Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)
9.Oat extract 2.0
(Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)
10. Birch extract 2.0
(Ethanol: 1,3-butylene glycol = 1: 1 extraction solvent)
11.Liquid shea fat 1.0
12.Collagen dispersion 10.0
13. Preservative (Acrinol) 0.1
14. Fragrance (sage water) appropriate amount
15. Purified water Residue when the total amount of each component is 100 (Formulation Example 12) Emollient cream
1.Stearic acid 2.0
2. Stearyl alcohol 7.0
3.Reduced lanolin 2.0
4.Squalane 5.0
5. Octyldodecanol 6.0
6. Polyoxyethylene cetyl ether (25E.O.) 3.0
7. Lipophilic glyceryl monostearate 2.0
8.Propylene glycol 5.0
9. Anaaaosa 50% 1,3-butylene glycol extract 3.0
10. Rosemary 50% 1,3-butylene glycol extract 3.0
11. Pine leaf or bark 50% 1,3-butylene glycol extract 3.0
12. Orange 50% 1,3-butylene glycol extract 3.0
13.Collagen dispersion 10.0
14. Preservative (paraben) appropriate amount
15. Perfume (clove water) appropriate amount
16. Purified water Residue when the total amount of each component is 100 (Formulation Example 13) Face-wash cream
1.Myristic acid 25.0
2.Stearic acid 5.0
3. Tallow fatty acid 5.0
4.Propylene glycol 10.0
5.Potassium hydroxide 6.0
6. Palm oil fatty acid diethanolamide 6.0
7.Aonori extract 2.0
(Ethanol: 1,3-butylene glycol = 1: 2 extraction solvent)
8. Eucalyptus leaf 50% 1,3-butylene glycol extract 2.0
9. Persimmon leaves 50% 1,3-butylene glycol extract 2.0
10. Western Tochinoki 50% 1,3-butylene glycol extract 2.0
11.Dipotassium glycyrrhetinate 1.0
12.Collagen dispersion 10.0
13. Preservative (salicylic acid) 0.1
14. Fragrance (sage water) appropriate amount
15. Purified water Residue when the total amount of each component is 100 (Formulation Example 14) Face-wash cream
1.Stearic acid 10.0
2.palmitic acid 10.0
3.Myristic acid 12.0
4.Lauric acid 4.0
5.Oleyl alcohol 1.5
6. Lanolin derivative (EO adduct) 1.0
7.Glycerin 18.0
8.Potassium hydroxide 6.0
9.Collagen dispersion 10.0
10. Royal Jelly Extract 1.0
(Ethanol: 1,3-butylene glycol = 1: 1 extract)
11.Glycyrrhizic acid 1.0
12. Antiseptic (salicylic acid) 0.1
13. Perfume (today water) appropriate amount
14. Purified water Residue when the total amount of each component is 100 (Formulation Example 15) Body soap
1.Potassium laurate 15.0
2.Collagen dispersion 5.0
3. Potassium myristate 5.0
4.Propylene glycol 5.0
5. Whey 1.5
6. Kirinsai 70% 1,3-butylene glycol extract 0.5
7. Hijirimene 70% 1,3-butylene glycol extract 0.5
8. Wakame 70% 1,3-butylene glycol extract 0.5
9. valerian 70% 1,3-butylene glycol extract 0.5
10.Polyethylene powder 0.5
11.Hydroxypropyl chitosan solution 0.5
12. Amino acids (glycine, glutamine, etc.) 0.5
13. Preservative (Undecylenic acid, phenol)
14.Adjustable pH adjuster
15. Perfume (shower water) appropriate amount
16. Purified water Residue when the total amount of each component is 100 (Formulation Example 16) Sunscreen cosmetics (O / W type)
1.Oxybenzone 2.0
2. Collagen dispersion 1.0
3.Octyl paramethoxycinnamate5.0
4.Squalane 10.0
5.Vaseline 5.0
6. Stearyl alcohol 3.0
7.Stearic acid 3.0
8. Glyceryl monostearate 2.0
9.Polyethyl acrylate 1.0
10.1,3-Butylene glycol 6.0
11. Edetate disodium 0.1
12.Triethanolamine 1.0
13.Titanium dioxide 5.0
14.Suginori 50% dipropylene glycol extract 0.5
15. Peony skin 50% dipropylene glycol extract 0.5
16. Birch bark 50% dipropylene glycol extract 0.5
17. Nadir 50% dipropylene glycol extract 0.5
18. Saiko 50% dipropylene glycol extract 0.5
19. Preservative (paraben) appropriate amount
20. Perfume (apple water) appropriate amount
21. Purified water Residue when the total amount of each component is 100 (Formulation Example 17) Sunscreen cosmetics (oil type)
1.liquid paraffin 70.0
2. Collagen dispersion 2.0
3.Ethyl paraaminobenzoate 1.0
4.Tetrahydroxybenzophenone 1.0
5.Cetyl octanoate 25.0
6. Hibamata water extract 1.0
7.Hijiki water extract 1.0
8.Glue water extract 0.5
9.Avocado water extract 0.5
10.Tachigasou water extract 0.5
11.Comfrey water extract 0.5
12. Antioxidant (Butylhydroxytoluene)
13. Fragrance (jasmine water) appropriate amount (Prescription Example 18) Cream Foundation (O / W type)
1.Stearic acid 4.0
2.Glycerol monostearate3.0
3. Collagen dispersion 2.0
4.Cetanol 1.5
5.Isopropyl myristate 7.0
6. Liquid paraffin 10.0
7. Sarah Beeswax 3.0
8.Triethanolamine 1.5
9.Glycerin 3.0
10. Bentonite 1.0
11.Titanium oxide 8.0
12.2,4-Dihydroxybenzophenone 8.0
13.Kaolin 3.0
14. Talc 3.0
15. Colored pigment (yellow iron oxide) 1.0
16.Comb 70% ethylene glycol extracted dry powder 0.2
17. Mulberry leaf 70% ethylene glycol extracted dry powder 0.2
18. Preservative (paraben) appropriate amount
19. Fragrance (white sand water) appropriate amount
20. Purified water Residue when the total amount of each component is 100 (Formulation Example 19) Shampoo
1.Lauryl sulfate triethanolamine 5.0
2. Sodium polyoxyethylene lauryl ether sulfate 12.0
3.Collagen dispersion 10.0
4.1,3-Butylene glycol 4.0
5.Lauric acid diethanolamide 2.0
6. Disodium edetate 0.1
7. Umiuchiwa 30% 1,2-butylene glycol extract 2.0
8. Mallow 30% 1,2-butylene glycol extract 2.0
9. Mulberry skin 30% 1,2-butylene glycol extract 2.0
10.Kakkon 30% 1,2-butylene glycol extract 1.0
11.Hydroxypropyl chitosan solution 2.0
12. Mucopolysaccharide solution 1.0
13. Antibacterial and antiseptic (photosensitive element 101) appropriate amount
14.Adjustable pH adjuster
15. Fragrance (Hamamelis water) appropriate amount
16. Purified water Residue when the total amount of each component is 100 (Formulation Example 20) Rinse
1. Stearyltrimethylammonium chloride 2.0
2.Cetostearyl alcohol 2.0
3.Polyoxyethylene lanolin ether 3.0
4. Collagen dispersion 4.0
5.Propylene glycol 5.0
6.Kotojitsu no Mata 50% 2,3-butylene glycol extract 1.0
7. Chamomile 50% 2,3-butylene glycol extract 1.0
8. Savonso 50% 2,3-butylene glycol extract 1.0
9. Forsythia 50% 2,3-butylene glycol extract 1.0
10.Hydroxyethyl chitosan solution 1.0
11. Trehalose solution 1.0
12. Hydrolyzed silk solution 1.0
13. Antibacterial and antiseptic (benzalkonium chloride) appropriate amount
14. Fragrance (lavender water) appropriate amount
15. Purified water Residue when the total amount of each component is 100 (Formulation Example 21) Rinse
1. Stearyltrimethylammonium chloride 2.0
2.Cetostearyl alcohol 2.0
3. Collagen dispersion 2.0
4.Polyoxyethylene lanolin ether 3.0
5.Propylene glycol 5.0
6.Ethylene glycol 3.0
7. Wakame 50% ethylene glycol extract 1.0
8. Forsythia 50% ethylene glycol extract 1.0
9. Strawberry 50% ethylene glycol extract 1.0
10. Trehalose solution 1.0
11. Hydrolyzed keratin solution 1.0
12. Antibacterial and antiseptic (benzalkonium chloride) appropriate amount
13. Perfume (camomile water) appropriate amount
14. Purified water Residue when the total amount of each component is 100 (Formulation Example 22) Hair Liquid
1.Ethanol 29.0
2.Polyoxypropylene butyl ether phosphate 10.0
3.Polyoxypropylene monobutyl ether 5.0
4.Collagen dispersion 5.0
5.Triethanolamine 1.0
6.Suginori hot water extract 2.0
7. Umiuchiwa hot water extract 2.0
8. Apricot fruit or leaf hot water extract 1.0
9. Spicy hot water extract 1.0
10.Ginkgo Leaf Hot Water Extract 1.0
11.Carpronium chloride 0.3
12. Hinokitiol 0.5
13.Keratin degradation solution 1.0
14. Antibacterial and antiseptic (paraben, benzalkonium chloride) appropriate amount
15. Fragrance (camomile water) appropriate amount
16. Purified water Residue when the total amount of each component is 100 (Formulation Example 23) Hair Liquid
1.Ethanol 29.0
2.Polyoxypropylene butyl ether phosphate 10.0
3.Polyoxypropylene monobutyl ether 5.0
4.Collagen dispersion 5.0
5.Triethanolamine 1.0
6. Trimethylene glycol 5.0
7. Propaganda 50% propylene glycol extract 1.0
8. Ogon 50% ethanol extract 1.0
9. Artemisia 50% ethanol extract 1.0
10. Oolong tea 50% ethanol extract 1.0
11.azulene 1.0
12. Antibacterial and antiseptic (paraben, benzalkonium chloride) appropriate amount
13. Fragrance (Western light load water) appropriate amount
14. Purified water Residue when the total amount of each component is 100 (Formulation example 24) Hair artic
1.Ethanol 40.0
2.Ethyl oleate 1.0
3.Polyoxyethylene (40) hydrogenated castor oil 2.0
4. Collagen dispersion 2.0
5. Peony skin 60% ethanol extract 3.0
6. Coconut leaf or fruit 60% ethanol extract 3.0
7. Preservative (paraben) appropriate amount
8. Purified water Residue when the total amount of each component is 100 (Formulation example 25) Hair art l-menthol 0.2
2.Ethanol 32.5
3.Polyoxyethylene hydrogenated castor oil 0.5
4. Collagen dispersion 1.0
5.Propylene glycol 5.0
6.Diphenhydramine hydrochloride 0.3
7.Hijirimen hot water extract 2.0
8. Rakan Fruit Hot Water Extract 1.0
9.Corn hot water extract 1.0
10. Chicken crown extraction solution 1.0
11.Carboxymethylchitin solution 1.0
12. Vitamin E derivative 0.5
13. Antibacterial and antiseptic (paraben) 0.1
14. Fragrance (rose water) appropriate amount
15. Purified water Residue when the total amount of each component is 100 (Formulation Example 26) Hair growth / hair growth agent
1.Ethanol 60.0
2. Hibamata 50% propylene glycol extract 5.0
3. Ginseng 50% propylene glycol extract 2.0
4. Green tea 50% propylene glycol extract 2.0
5. Collagen dispersion 2.0
6. Yakomi 50% propylene glycol extract 1.0
7. Vitamin E derivative 0.5
8.Pepper tincture 0.5
9.Resorcin 0.5
10.Glycyrrhizic acid 0.5
11.Hydroxypropyl chitosan solution 0.5
12.Bovine hematin solution 0.5
13.Mucin solution 0.5
14. Amino acids (Glycine, Glutamine, etc.) 0.5
15. Antibacterial and antiseptic (paraben) 0.1
16. Fragrance (rosemary water)
17. Purified water Residue when the total amount of each component is 100 (Formulation example 27) Hair growth and hair nourishing agent
1.Ethanol 60.0
2.Collagen dispersion 20.0
3. Hijirimene 50% 1,3-butylene glycol extract 1.0
4. Tree bark or fruit 50% 1,3-butylene glycol extract 1.0
5. Asunal bark 50% 1,3-butylene glycol extract 1.0
6. Cantalis tincture 0.5
7. Pantothenic acid derivative 0.5
8.Glycyrrhizic acid 0.5
9.Resorcin 0.5
10.salicylic acid 0.5
11.Hydroxyethyl chitosan solution 0.5
12.Elastin hydrolyzate 0.5
13. Antibacterial and antiseptic (paraben) 0.1
14. Fragrance (lavender water) appropriate amount
15. Purified water Residue when the total amount of each component is 100 (Formulation Example 28) Granule bath preparation
1.Sodium bicarbonate 58.0
2.Anhydrous sodium sulfate 30.0
3.Collagen dispersion 5.0
4. Borax 2.0
5. Tengusa hot water extraction dry powder 5.0
6. Western thin cargo hot water extraction dry powder 5.0
7. Dye (Gungjo Green) appropriate amount (Formulation Example 29) Granule bath preparation
1.Sodium bicarbonate 58.0
2.Anhydrous sodium sulfate 30.0
3.Collagen dispersion 5.0
4. Borax 4.0
5.Hijiki 70% ethanol extracted dry powder 1.0
6. Cinnamon 70% ethanol extracted dry powder 1.0
7.Summer mandarin 70% ethanol extract dry powder 1.0
8. Rose flower 70% ethanol extract dry powder 1.0
9. Aloe pulp 70% ethanol extracted dry powder 1.0
10. Apple juice powder 1.0
11. Dye (Gunjou, chromium hydroxide) appropriate amount
12. Fragrance (hamamelis water) Appropriate amount (Formulation example 30) Coating protective agent Gauze or liniment cloth is impregnated with a prescription solution in which appropriate amounts of collagen dispersion, Kotojitsunotama hot water extract, antibiotics, anti-inflammatory, etc. are mixed, and the wound Attach to

  The dispersion according to the present invention is for topical use such as basic cosmetics such as lotion, emulsion, cream, ointment, lotion, oil, pack, foundation, lipstick, blusher, eye shadow, eyeliner, mascara, perfume, etc. Or systemic cosmetics, facial cleansers and skin cleansers, massage agents, cleansing agents, hair removal agents, hair removal agents, shaving treatments, after shave lotions, pre-show lotions, shaving creams, shampoos, rinses, treatments It can be suitably used as a raw material or product for various cosmetics and quasi-drugs such as permanent liquids, hair dyes, hair styling agents, hair styling agents, hair growth and hair nourishing agents.

Claims (1)

  Fine particles of insoluble collagen having a particle size of 200 μm or less obtained by pulverizing fish scales having an ash content of 2% by weight or less and an oil / fat content of 0.3% by weight or less are dispersed in a solvent, and are water-soluble as a dispersion stabilizer. Collagen dispersion for skin containing collagen.