JP4065082B2 - Liquid container and method for producing stretch blow molded bottle for liquid - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a liquid container that can be suitably used as an eye drop container, and a method for producing a bottle, which is a main component of the container, by a stretch blow molding method.
[0002]
[Prior art]
For example, as a bottle for a liquid medicine such as eye drops, conventionally, stretch blow molded products made of a polymer synthetic resin material have been widely used, and injection molded bottles have also been used. In particular, since chemicals such as eye drops are applied to the human body, sufficient water vapor barrier property and gas barrier property are required so that the liquid property does not change as much as possible by long-term storage, and sufficient consideration is given to material selection. Yes.
[0003]
For example, transparent olefin-based materials such as PP, LDPE, HDPE or COP (Circle Olefin Polymer) have been conventionally used as molding materials for eye drop bottles.
Olefinic materials are high in chemical resistance and excellent in water vapor barrier properties. Therefore, in the field of chemical liquid containers as described above, olefin materials are preferable materials from the viewpoint of preventing changes in medicinal components associated with water vapor permeation loss. Furthermore, since the olefin-based material is a relatively flexible material, there are few restrictions on the bottle shape, and sufficient squeeze properties (compression deformability by pressing) can be obtained even when molded into a simple bottomed cylindrical bottle shape. . With a bottomed cylindrical bottle shape, a bottle transport path using guide rails can be formed in a production line that performs chemical filling into the bottle after blow molding, so a production system with excellent mass productivity is available. There is an advantage that it can be constructed.
[0004]
[Problems to be solved by the invention]
However, some medicinal ingredients and preservatives are adsorbed on olefinic resin materials, absorbed or sorbed. Examples of such medicinal ingredients include vitamin E (PL-α-tocopherol), and examples of the preservative include β-phenylethyl alcohol (β-PEA), benzalkonium chloride (BKC), and the like. Can be mentioned. As a container for such a drug containing a medicinal component or a preservative, a polyester-based transparent resin material that does not adsorb the medicinal component or the preservative is used. Since polyester-based resins such as PET and PEN have a relatively high water vapor permeability, pillow packaging or the like is applied in order to prevent changes in the medicinal components associated with water vapor transmission loss. On the other hand, there are drugs that dislike contact with polyester. In this case, polyolefin-based materials are used. ₂ Since the barrier function is insufficient, pillow packaging and oxygen scavengers are used in this case as well.
[0005]
Polyester-based materials are relatively hard materials, so in order to provide the necessary squeeze characteristics for eyedrop bottles while having some water vapor barrier properties, gas barrier properties, etc., it is necessary to design a flat cross-section bottle shape. First, the production line needs to be significantly modified according to the change in the container shape. Therefore, in order to use the existing production line, the actual situation is that the chemicals that can be produced are limited.
[0006]
The present invention can reduce both the adsorptivity and water vapor permeability of medicinal components, increase the degree of freedom of the bottle shape, and can use a production line with high mass productivity, and stretching It aims at providing the manufacturing method of a blow molding bottle.
[0007]
[Means for Solving the Problems]
In order to achieve the above object, the applicant of the present application includes a bottle having a body portion and a mouth portion, and a cap that is detachably attached to the mouth portion of the bottle, and the bottle is made of a synthetic resin layer made of a different material. Invented a container for a liquid agent that is formed by laminating the inside and outside. According to this, for example, the resin material constituting the inner synthetic resin layer of the wall of the bottle body is a saturated polyester having a low medicinal component adsorptivity, while the resin material constituting the outer synthetic resin layer is water vapor. By using polyolefin with a high barrier property, the disadvantages of both can be covered with each other, a chemical solution container with a low medicinal component adsorption property and a high water vapor barrier property can be provided, and the medicinal component changes even after long-term storage Can prevent. Furthermore, since the saturated polyester of the inner synthetic resin layer only needs to function as a protective layer against medicinal components, the desired thickness can be easily reduced by making the relatively hard saturated polyester layer as thin as possible, Since the degree of freedom in designing the shape is increased and the bottle can be configured as a bottomed cylindrical bottle, a production line with high mass productivity can be used, and mass productivity and cost reduction can be achieved.
[0008]
The liquid container using the laminated bottle has the advantages as described above. However, the inventors have found that the laminated bottle causes the following problems. That is, immediately after the molding of the bottle, the inner synthetic resin layer and the outer synthetic resin layer are in close contact with each other due to the adhesiveness of these constituent resin materials, but the saturated polyester of the inner synthetic resin layer is the outer synthetic resin. Since the water vapor permeability is larger than the polyolefin of the layer, the inner synthetic resin layer and the outer synthetic resin layer are partially peeled off by the atmospheric pressure of water vapor that passes through the inner synthetic resin layer, and the wall of the bottle body Will appear as a bubble-like pattern. When such a phenomenon occurs, even if there is no quality deterioration as a drug due to deterioration of its appearance, it is often discarded for safety, and it is necessary to improve the bottle structure and the like.
[0009]
It is considered that the bubble-like peeled portion is generated at the interface between the inner synthetic resin layer and the outer synthetic resin layer in the above laminated bottle because of the low adhesion of polyolefin. In order to prevent the appearance of a bubble-like pattern, the inner synthetic resin layer and the outer synthetic resin layer are peeled off in advance, or the adhesive force between the inner synthetic resin layer and the outer synthetic resin layer. Should be strengthened.
[0010]
The container for liquid preparations of the present invention made based on such knowledge includes a bottle having a trunk portion and a mouth portion, and a cap that is detachably attached to the mouth portion of the bottle, and the bottle has different synthetic resin layers. Is formed by laminating the inside and outside of the bottle body, and is not characterized by having no mutual adhesiveness between the inner synthetic resin layer and the outer synthetic resin layer of the bottle body. According to this, immediately after the bottle is molded, the inner synthetic resin layer and the outer synthetic resin layer are bonded to each other by the intermolecular bonding force caused by thermoforming. Since the adhesion between each other is eliminated by peeling the layer and the outer synthetic resin layer in advance, no bubble-like pattern appears on the body even when stored for a long time, and a good appearance is maintained. Can do. Note that the inner synthetic resin layer and the outer synthetic resin layer may be peeled in advance at the mouth and bottom of the bottle, but the inner synthetic resin layer and the outer synthetic resin layer are prevented from rotating relatively. Therefore, it is preferable that the inner synthetic resin layer and the outer synthetic resin layer are bonded to each other at the mouth and bottom of the bottle that do not affect the appearance as much as possible.
[0011]
The liquid container of the present invention includes a bottle having a body portion and a mouth portion, and a cap that is detachably attached to the mouth portion of the bottle, and the bottle is laminated with synthetic resins of different materials on the inside and outside. The additive material that is formed and that enhances the adhesion between the inner synthetic resin layer and the outer synthetic resin layer on the wall of the bottle body is formed of the synthetic resin and / or the outer synthetic resin constituting the inner synthetic resin layer. It is characterized by being mixed in a synthetic resin constituting the resin layer. According to this, since the adhesive force between the inner synthetic resin layer and the outer synthetic resin layer of the bottle is enhanced by the mixing of the additive material, the inner synthetic resin layer and the outer synthetic resin layer are difficult to peel off, and the body portion A bubble-like pattern is prevented from appearing on the surface.
[0012]
The laminated bottle can be molded by an appropriate molding method such as an injection molding method, a direct blow molding method, or an injection blow molding method. However, considering the mass productivity and cost, different types of synthetic resins can be used. It is preferable to form by stretch blow molding using a laminated parison laminated on.
[0013]
In each of the liquid container, the inner and outer synthetic resin layers can be unevenly fitted at the bottle mouth. For example, by using an injection molding machine, first, a PET parison having vertical ribs and horizontal ribs is formed on the outer periphery of the mouth, and this PET parison is inserted into another injection mold, and PP is formed on the outer periphery thereof. Is formed by injection molding to obtain a structure in which the PET of the inner synthetic resin layer and the PP of the outer synthetic resin layer are unevenly fitted at the mouth. According to this, in the case where the inner synthetic resin layer and the outer synthetic resin layer are peeled in advance at the bottle body, a strong bond is obtained between the inner synthetic resin layer and the outer synthetic resin layer at the mouth. Even in the case of a cylindrical bottle, the inner synthetic resin layer and the outer synthetic resin layer do not rotate relative to each other, and the operability of the cap screwed into the bottle mouth is improved. Airtightness at the time of wearing is improved. In addition, in the case where the adhesion between the inner synthetic resin layer and the outer synthetic resin layer of the bottle is improved, a strong bond between the inner synthetic resin layer and the outer synthetic resin layer is obtained at the mouth, so that the cap is repeatedly attached and detached. Even if it goes, it can prevent that a stress acts on the interface of the inner side synthetic resin layer and outer side synthetic resin layer of a bottle trunk | drum, and these are prevented from peeling.
[0014]
The present invention is suitably implemented when the bottle is a bottomed cylindrical eye drop bottle having squeeze properties in its body. In addition, saturated polyester such as PET (polyethylene terephthalate) or PEN (polyethylene naphthalate) is used for the inner synthetic resin layer material of the bottle, and PP (polypropylene), PE (polyethylene) or COP (polypropylene) is used for the outer synthetic resin layer material. It is preferred to use polyolefins such as Circle Olefin Polymer). On the contrary, when polyolefin is used for the inner synthetic resin layer material of the bottle and saturated polyester is used for the outer synthetic resin layer material, the oxygen barrier function is ensured and the diffusion preventing action of the gas component such as the content fragrance is improved. In this case, it is possible to prevent bubbles from being generated between the inner and outer layers.
[0015]
Further, in the liquid container, a cap is attached to the mouth so as to cover the outer peripheral side of the bottle mouth in order to further reduce water vapor permeation loss, and the lower peripheral edge of the cap is the outer surface of the bottle. It is possible to make the structure in airtight contact. According to this, a flange portion extending outward is formed at the upper end (open end) of the inner synthetic resin layer due to the structure of the molding machine and the necessity of the molding process, and the outer synthetic resin layer is formed below the flange portion. In the case of being laminated, water vapor may leak out in a small amount into the space between the cap and the bottle mouth through the flange portion of the inner synthetic resin layer having a relatively large water vapor permeability. However, by keeping the lower end periphery of the cap airtightly in contact with the outer surface of the bottle, water vapor can be prevented from leaking out of the cap, and water vapor leakage from the lower end of the cap during long-term storage can be eliminated. Needless to say, it is preferable to use a material having a high water vapor barrier property (for example, polyolefin, metal, etc.) as the constituent material of the cap.
[0016]
The bottle from which the inner synthetic resin layer and the outer synthetic resin layer have been peeled in advance can be manufactured by the following method. That is, the stretch blow molded bottle manufacturing method of the present invention comprises a step of manufacturing a laminated parison formed by laminating different synthetic resins on the inside and outside, and a stretched blow molding of the laminated parison in a blow mold to form a body portion and a mouth. And a step of peeling the inner synthetic resin layer and the outer synthetic resin layer of the wall portion of the bottle body. In the production of the laminated parison, the inner synthetic resin layer and the outer synthetic resin layer may be injection-molded using different injection molds, or may be molded by a two-layer extrusion molding machine. It can manufacture by the means of.
[0017]
In the manufacturing method, preferably, the inner synthetic resin layer material can be saturated polyester, and the outer synthetic resin layer material can be polyolefin. Moreover, peeling with an inner side synthetic resin layer and an outer side synthetic resin layer can be performed by pressing a bottle trunk | drum from the outer peripheral side and making it elastically deform, and can be made to peel by another appropriate means.
[0018]
In addition, another stretch blow molded bottle manufacturing method of the present invention manufactures a laminated parison in which an inner synthetic resin layer made of saturated polyester and an outer synthetic resin layer made of polyolefin to which an α-olefin is added and mixed are laminated. And a step of stretch-blow-molding the laminated parison in a blow-molding die to form a bottle having a body portion and a mouth portion. According to this, since the α-olefin that enhances the adhesiveness is added to and mixed with the polyolefin, good adhesiveness is obtained between the inner synthetic resin layer and the outer synthetic resin layer after the blow molding, and the cellular pattern Is prevented from appearing.
[0019]
DETAILED DESCRIPTION OF THE INVENTION
Hereinafter, embodiments of the present invention will be described together with illustrated examples.
[0020]
[First Embodiment]
FIG. 1 schematically shows an eye drop container 1 which is a container for liquid medicine according to a first embodiment of the present invention. The container 1 includes a bottle 4 having a mouth 2 and a body 3. The nozzle 5 attached to the mouth 2 of the bottle 4 and the cap 6 detachably attached to the mouth 2 are provided.
[0021]
The bottle 4 is a bottomed cylindrical eye drop bottle whose body 3 has squeeze properties. Therefore, the cap 6 is removed from the mouth part 2 and the bottle 4 is turned upside down, and the body part 3 is elastically deformed radially inward by pressing the body part 3 with a finger or the like from the outer peripheral side. It is possible to instill a drug solution. Further, the mouth portion 2 of the bottle 4 is opened at the upper side, and a helical screw portion 7 for attaching a cap is provided on the outer periphery.
[0022]
The bottle 4 is formed by laminating and forming synthetic resin layers 8 and 9 of different materials inside and outside. Such a laminated bottle 4 can be molded using a conventionally known appropriate method such as an injection molding method, a direct blow molding method, or an injection blow molding method. A characteristic part of the bottle 4 according to this embodiment is that the inner synthetic resin layer 8 and the outer synthetic resin layer 9 of the bottle body 3 are peeled over the entire circumference. That is, when the bottle 4 having the inner and outer synthetic resin layers 8 and 9 is molded by an injection molding method, a stretch blow molding method, or the like, the resin is heated to the extent that the resin is plasticized at the time of molding. Adhesiveness is exhibited. In this embodiment, after the bottle is cooled and solidified, the inner layer 8 and the outer layer 9 of the bottle body 3 are separated by an appropriate means.
[0023]
For example, as shown in FIG. 2, the peeling can be performed by disposing a rubber roller 10 in the middle of the production line and pressing the bottle body 3 from the outside in the radial direction by the roller 10. In the illustrated example, a plurality of pressing rollers 10 are disposed in the conveyance direction on both sides in the width direction of the guide rail 11 in the middle of the production line, and each roller 10 is driven to rotate, and the number of rotations of each roller 10 on both sides in the width direction. Thus, the peripheral wall portion of the body portion 3 can be compressed and deformed radially inward while rotating the bottle 4. The present invention is not limited to such a peeling method, and the inner layer 8 and the outer layer 9 can be peeled by an appropriate method. Since the adhesive force between the inner layer 8 and the outer layer 9 immediately after the bottle molding is due to the weak bonding force between the molecules constituting these layers, the layers 8 and 9 come into contact with each other after the above-described peeling process. It will be in a state which does not have mutual adhesiveness between these.
[0024]
As a constituent material of the inner synthetic resin layer 8, a polyester synthetic resin material can be used. Polyester is a polymer material synthesized by condensation polymerization. Condensation polymerization is a sequential polymerization reaction in which low molecules such as water and alcohol are removed from two molecules at high temperature and in a vacuum atmosphere, and the molecular weight is gradually increased. Since this polyester has a polar group called an ester bond, it has a strong van der Waals force acting between molecules, and is generally known as a relatively hard polymer material. As polyester-based synthetic resin materials, in addition to polyester, saturated polyesters such as PET (polyethylene terephthalate) and PEN (polyethylene naphthalate) are known.
[0025]
PET has the properties of being colorless and transparent, glossy, odorless and excellent in gas barrier properties. When PET is used for the inner layer 8 of the injection blow molded bottle, as a raw material, for example, a solid phase polymerization PET resin having IV = 0.8 or more can be used. A bottomed cylindrical parison is injection-molded using this PET resin, and an outer synthetic resin layer 9 to be described later is laminated on the outer peripheral side of the PET parison to produce a laminated parison 12 shown in FIG. Is inserted into a blow mold (not shown) and stretch blow molded to obtain the laminated bottle 4 described above.
[0026]
When PET is used for the inner layer 8 of the direct blow molded laminated bottle, the viscosity of the molten PET resin must be high in order to extrude it into a tube shape, and the physical properties of the PET itself must be high because the bottle is not stretched. Don't be. Therefore, a solid phase polymerization PET resin having IV = 1.0 or more is usually used for small direct blow bottle molding.
[0027]
PEN (polyethylene naphthalate) is a polyester obtained by condensation polymerization from 2,6 naphthalene dicarboxylic acid and ethylene glycol. This PEN also has properties of relatively high heat resistance, gas barrier properties, and strength, and can be handled in the same manner as PET.
[0028]
As the constituent material of the outer synthetic resin layer 9, an olefin-based synthetic resin material can be used, and preferably, polyolefin such as PP (polypropylene), PE (polyethylene), or COP (Circle Orefin Polymer) is used.
[0029]
PE is roughly classified into LDPE (low density polyethylene) and HDPE (high density polyethylene), and any of these can be used as the bottle constituting material of the present invention.
[0030]
Returning to the description of the bottle structure, in the bottle mouth portion 2, the inner synthetic resin layer 8 and the outer synthetic resin layer 9 are unevenly fitted so as to restrict relative movement in the bottle axial direction and the circumferential direction. . More specifically, a pair of upper and lower flange-like ribs 13 are formed on the outer periphery of the mouth of the inner layer 8 as shown in FIGS. 4 to 6. A plurality of vertical ribs 14 are formed at intervals in the circumferential direction. By molding the outer layer 9 on the outer surface side of the inner layer 8, the concave and convex fitting of the inner and outer layers 8 and 9 can be obtained. When the bottle 4 is molded by the blow molding method, the laminated parison 12 is molded by the injection molding method as shown in FIG. 3, and the mouth part 2 is attached to a lip mold (not shown) and blow molded. The parison 12 is inserted into the mold and stretch blow molded. In the illustrated embodiment, due to the mold structure, a flange portion 8a extending outward is formed at the upper end portion of the inner layer 8, and the outer layer 9 is laminated on the lower side of the flange portion 8a.
[0031]
Furthermore, when the Example which manufactures the bottle 4 by the injection blow molding method is given, for example, first, the PET preform which comprises the inner layer 8 is shape | molded and stocked using an injection molding machine. This PET preform is inserted into another mold, and PP constituting the outer layer 9 is injection-molded on the outer surface to obtain a laminated parison 12. The laminated parison 12 is heated and blown using a cold parison stretch blow molding machine to obtain the bottle 4 having the above structure. The injection molding step is a step of molding a cold parison, but two injection molding machines or a two-color molding machine may be used, and from injection molding to blow molding continuously. It is also possible to use a molding machine. In the manufacturing method of this embodiment, even if the heating of the parison before blow molding is only external heating, the inner layer PET can support PP and perform stable blow molding. In general, the PP method has a higher blowing temperature than PET, and PP cold parison cannot be stably blow-molded due to drawdown or deformation, but it is better to use laminated parison. Can be done.
[0032]
The nozzle 5 is substantially cylindrical as a whole, and is provided with a flange portion 5a that is in contact with the inner layer flange portion 8a in the middle of the upper and lower sides. The portion on the lower side of the flange portion 5a has a slightly tapered cylindrical shape and is inserted into the opening of the bottle inner layer 8. Various materials can be used as the constituent material of the nozzle 5, but those having high water vapor barrier properties, gas barrier properties, and chemical resistance are preferable. For example, polyolefin can be used.
[0033]
The cap 6 is attached to the mouth part 2 so as to cover the outer peripheral side and the upper part of the bottle mouth part 2, and has a peripheral wall part 6a and a canopy part 6b. On the inner surface of the peripheral wall portion 6a, a protrusion 15 that engages with the screw portion 7 of the mouth portion 2 is provided at an appropriate location, and the cap 6 can be attached and detached by rotating the cap 6 relative to the mouth portion 2. Is done. The inner surface of the canopy 6b is provided with a recess 16 for sealing the tip opening of the nozzle 5. By screwing the cap 6 into the mouth 2, the tip of the nozzle 5 is brought into close contact with the recess 16 and It is possible to prevent chemical leakage and water vapor transmission.
[0034]
Further, when the cap 6 is attached to the mouth portion 2, that is, when the tip of the nozzle 5 is brought into close contact with the concave portion 16, the peripheral edge of the lower end of the cap 6 is placed on the outer surface of the bottle 4 (in the illustrated example, the bottle 4). The shoulder part) in an airtight manner. According to this, even if there is a very small amount of water vapor permeating from the flange portion 8 a of the inner layer 8, the water vapor is prevented from leaking outward from the lower end portion of the cap 6 by contact between the cap 6 and the bottle 4. Further, by saturating the water vapor in the space in the cap 6, it is possible to prevent further water vapor transmission loss and to further improve the long-term storage stability.
[0035]
[Second Embodiment]
Hereinafter, the second embodiment of the present invention will be described. However, since most of the configuration is the same as that of the first embodiment, the same reference numerals are given and detailed description will be omitted, and different configurations and operational effects will be described.
[0036]
In the first embodiment, after the bottle 4 is formed, the inner layer 8 and the outer layer 9 are peeled in advance in the bottle body before filling with the liquid agent (chemical solution). However, in order to prevent bubble peeling, both layers It is also possible to improve these adhesiveness without peeling 8 and 9. The liquid container of this embodiment includes a bottle 4 having a body portion 3 and a mouth portion 2, and a cap 6 that is detachably attached to the mouth portion 2 of the bottle 4, and the bottle 4 is made of different materials. The synthetic resin layers 8 and 9 are laminated on the inside and outside, and an additive material for improving the adhesion between the inner synthetic resin layer 8 and the outer synthetic resin layer 9 of the bottle body 3 is an inner synthetic resin layer. 8 and / or the synthetic resin constituting the outer synthetic resin layer 9.
[0037]
The additive material is appropriately selected according to the synthetic resin material constituting the inner layer 8 and the outer layer 9. For example, when a saturated polyester is used as the inner synthetic resin material and a polyolefin is used as the outer synthetic resin material, the outer synthetic resin is made using a material obtained by adding a small amount of α-olefin (for example, 1-hexane) to the polyolefin. The layer 9 is injection molded so as to be laminated on the outer peripheral side of the inner synthetic resin layer 8. Thereby, the adhesiveness of the inner layer 8 and the outer layer 9 is improved, and peeling between the inner layer 8 and the outer layer 9 is prevented.
[0038]
As a method for producing such a bottle 4 by stretch blow molding, for example, a laminated parison in which an inner synthetic resin layer made of saturated polyester and an outer synthetic resin layer made of polyolefin to which α-olefin is added and mixed is injected. What includes a step of producing by a molding method and a step of forming the bottle having a body portion and a mouth portion by stretching and blow-molding the laminated parison in a blow mold. Of course, the bottle 4 can be manufactured by other appropriate methods.
The present invention is not limited to the above-described embodiments, and it is of course possible to change the design as appropriate. For example, when polyolefin is used as the inner layer material and saturated polyester is used as the outer layer material, it can be suitably used as a container for a liquid agent that dislikes contact with the polyester, and has improved oxygen barrier properties and a content flavoring agent. It is possible to prevent diffusion of gas components such as.
[0039]
【The invention's effect】
According to the liquid medicine container of the present invention, since a laminated bottle formed by laminating synthetic resin materials of different materials inside and outside can be achieved at once, reduction of adsorption of medicinal ingredients, elimination of water vapor transmission loss, etc. Even when stored for a long period of time, bubbles are not generated between the inner and outer layers of the bottle, and even when the outer layer has a higher water vapor barrier property, the occurrence of a bubble-like peeling phenomenon at the body is eliminated.
[Brief description of the drawings]
FIG. 1 is a front view of a half longitudinal section of a liquid container according to an embodiment of the present invention.
FIG. 2 is a simplified plan view in the middle of a production line showing a method of peeling the inner synthetic resin layer and the outer synthetic resin layer of the bottle of the same solution agent container.
FIG. 3 is a longitudinal sectional view of a laminated parison when the bottle is manufactured by a stretch blow molding method.
FIG. 4 is an enlarged perspective view showing a mouth structure of an inner layer synthetic resin of the same laminated parison.
FIG. 5 shows the mouth portion of the container for the same solution and the cap mounting structure, the left half is a vertical cross-sectional front view of a portion where no vertical rib is present, and the right half is a front view showing only the cap in cross section.
FIG. 6 is a longitudinal sectional view of a portion where a longitudinal rib is present, showing a mouth portion and a cap mounting structure of the same liquid medicine container.
[Explanation of symbols]
1 Liquid container (eye drops container)
2 mouths
3 trunk
4 bottles (eye drops bottles)
5 nozzles
6 Cap
8 Inner synthetic resin layer
9 Outer synthetic resin layer
12 Laminated parison
13 Horizontal ribs
14 Vertical rib

Claims (4)

  A bottle (4) having a body (3) and a mouth (2), and a cap (6) removably attached to the mouth (2) of the bottle (4), the bottle (4) Is formed by laminating and forming synthetic resin layers (8, 9) of different materials on the inner and outer sides, and the inner synthetic resin layer (8) and the outer synthetic resin layer (9) of the bottle body (3) The inner and outer synthetic resin layers (8, 9) are not ruggedly fitted so as to restrict relative movement in the bottle axial direction and circumferential direction at the bottle mouth (2). A container for liquid preparations.   A bottle (4) having a body (3) and a mouth (2), and a cap (6) removably attached to the mouth (2) of the bottle (4), the bottle (4) Is formed by laminating and forming synthetic resin layers (8, 9) of different materials on the inner and outer sides, and the inner synthetic resin layer (8) and the outer synthetic resin layer (9) of the bottle body (3) A flange portion (8a) that does not have mutual adhesiveness and extends outward at the upper end of the inner synthetic resin layer (8) is formed, and the outer synthetic resin layer ( 9) is laminated, and the cap (6) is attached to the mouth part (2) so as to cover the outer peripheral side of the bottle mouth part (2), and the lower end peripheral part of the cap (6) 4) is in airtight contact with the outer surface of the inner synthetic resin layer (8). Liquid agent container steam leaking into the space between the mouth-flop (6) (2) is characterized in that it prevented from leaking to the outside of the cap.   A step of manufacturing a laminated parison (12) formed by laminating different synthetic resins on the inside and outside, and a stretched blow molding of the laminated parison (12) in a blow mold to form a body (3) and a mouth (2) And a step of peeling the inner synthetic resin layer (8) and the outer synthetic resin layer (9) on the wall of the bottle body (3), and forming the inner synthetic resin. The layer (8) is made of saturated polyester, the outer synthetic resin layer (9) is made of polyolefin, and the inner synthetic resin layer (8) and the outer synthetic resin layer (9) are separated from each other by the bottle body (3). A method for producing a stretch blow-molded bottle for a liquid agent, characterized in that it is elastically deformed by pressing from the outer peripheral side.   A step of producing a laminated parison (12) in which an inner synthetic resin layer (8) made of saturated polyester and an outer synthetic resin layer (9) made of polyolefin to which an α-olefin is added and mixed, and the laminated parison And (12) stretch blow molding in a blow mold to form a bottle (4) having a body portion (3) and a mouth portion (2). Manufacturing method.

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