JP4063879B2 - 所望の決定基に対する免疫応答の誘導 - Google Patents

所望の決定基に対する免疫応答の誘導 Download PDF

Info

Publication number
JP4063879B2
JP4063879B2 JP52697997A JP52697997A JP4063879B2 JP 4063879 B2 JP4063879 B2 JP 4063879B2 JP 52697997 A JP52697997 A JP 52697997A JP 52697997 A JP52697997 A JP 52697997A JP 4063879 B2 JP4063879 B2 JP 4063879B2
Authority
JP
Japan
Prior art keywords
peptide
composition
alanine
peptides
residue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP52697997A
Other languages
English (en)
Japanese (ja)
Other versions
JP2000504328A (ja
JP2000504328A5 (cg-RX-API-DMAC7.html
Inventor
ジェフリー エル アレクサンダー
ショーン デフリーズ
アレッサンドロ セッティ
Original Assignee
エピミューン インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by エピミューン インコーポレイテッド filed Critical エピミューン インコーポレイテッド
Publication of JP2000504328A publication Critical patent/JP2000504328A/ja
Publication of JP2000504328A5 publication Critical patent/JP2000504328A5/ja
Application granted granted Critical
Publication of JP4063879B2 publication Critical patent/JP4063879B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/385Haptens or antigens, bound to carriers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K9/00Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • A61K2039/605MHC molecules or ligands thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Steroid Compounds (AREA)
  • Control Of High-Frequency Heating Circuits (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP52697997A 1996-01-24 1997-01-23 所望の決定基に対する免疫応答の誘導 Expired - Lifetime JP4063879B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1051096P 1996-01-24 1996-01-24
US60/010,510 1996-01-24
PCT/US1997/001041 WO1997026784A1 (en) 1996-01-24 1997-01-23 Induction of immune response against desired determinants

Publications (3)

Publication Number Publication Date
JP2000504328A JP2000504328A (ja) 2000-04-11
JP2000504328A5 JP2000504328A5 (cg-RX-API-DMAC7.html) 2004-11-11
JP4063879B2 true JP4063879B2 (ja) 2008-03-19

Family

ID=21746084

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52697997A Expired - Lifetime JP4063879B2 (ja) 1996-01-24 1997-01-23 所望の決定基に対する免疫応答の誘導

Country Status (12)

Country Link
EP (1) EP0876398B1 (cg-RX-API-DMAC7.html)
JP (1) JP4063879B2 (cg-RX-API-DMAC7.html)
CN (1) CN1214051A (cg-RX-API-DMAC7.html)
AT (1) ATE220687T1 (cg-RX-API-DMAC7.html)
AU (1) AU1582797A (cg-RX-API-DMAC7.html)
BR (1) BR9710404A (cg-RX-API-DMAC7.html)
CA (1) CA2242878C (cg-RX-API-DMAC7.html)
DE (1) DE69714011T2 (cg-RX-API-DMAC7.html)
DK (1) DK0876398T3 (cg-RX-API-DMAC7.html)
ES (1) ES2177927T3 (cg-RX-API-DMAC7.html)
PT (1) PT876398E (cg-RX-API-DMAC7.html)
WO (1) WO1997026784A1 (cg-RX-API-DMAC7.html)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6528061B1 (en) * 1997-09-04 2003-03-04 Pasteur Institut Immunogenic polypeptides that mimic a surface polysaccharide antigen of a pathogenic microorganism, method for obtaining the same, and their use in vaccine compositions
EP1903056A3 (en) 2002-12-10 2008-05-07 Idm Pharma, Inc. HLA-A1, -A2 -A3, -A24, -B7, and -B44 binding peptides comprising tumor associated antigen epitopes, and compositions thereof
CA2505870A1 (en) * 2002-12-11 2004-06-24 Soren Mouritsen Targeting single epitopes
AU2004232971A1 (en) 2003-04-18 2004-11-04 Idm Pharma Inc. HLA-A2 tumor associated antigen peptides and compositions
ES2310072B1 (es) 2005-12-23 2009-11-16 Proyecto De Biomedicina Cima, S.L. Nuevos peptidos determinantes antigenicos t colaboradores (/dth).
WO2009025777A1 (en) * 2007-08-17 2009-02-26 University Of Maryland Carbohydrate functionalized catanionic surfactant vesicles for drug delivery
JP5792630B2 (ja) * 2009-01-28 2015-10-14 エピミューン,インコーポレイティド Pan−dr結合ポリペプチドおよびその使用
WO2012123269A1 (en) 2011-03-11 2012-09-20 Proyecto De Biomedicina Cima, S.L. Immunogenic compositions and methods for their use
US10588952B2 (en) * 2013-03-29 2020-03-17 Sumitomo Dainippon Pharma Co., Ltd. Conjugate vaccine using trimming function of ERAP1
EP2982681B8 (en) 2013-03-29 2018-11-07 Sumitomo Dainippon Pharma Co., Ltd. Wt1-antigen peptide conjugate vaccine
EP3028048B1 (en) 2013-07-31 2018-09-26 BioVentures, LLC Compositions for treating and preventing cancer targeting tumor associated carbohydrate antigens
MX2016012124A (es) * 2014-03-19 2017-04-06 Mackay Medical Found The Presbyterian Church In Taiwan Mackay Memorial Hospital Anticuerpos contra glicopeptidos inmunogenicos, composicion que los comprende y usos de estos.
JP7209963B2 (ja) 2016-11-30 2023-01-23 住友ファーマ株式会社 Wt1ヘルパーペプチド及びこれと癌抗原ペプチドコンジュゲート体との組合せ
CN107141355B (zh) * 2017-05-31 2021-05-14 中国人民解放军第四军医大学 一种htnv抗原表位线性串联多肽及表位肽-复合物四聚体和应用
CN109991422A (zh) * 2017-12-29 2019-07-09 复旦大学 基于特异抗血清的棕榈酰化修饰蛋白质的检测方法
EP4149531A1 (en) 2020-05-11 2023-03-22 Ose Immunotherapeutics Vaccine against sars-cov virus
KR102261457B1 (ko) * 2020-07-22 2021-06-09 (주)쓰리에이치바이오 면역 치료제용 펩타이드
KR20230042053A (ko) * 2020-07-22 2023-03-27 (주)쓰리에이치바이오 면역 치료제용 펩타이드
WO2022268916A2 (en) 2021-06-23 2022-12-29 Ose Immunotherapeutics Pan-coronavirus peptide vaccine
CN119256003A (zh) 2022-04-14 2025-01-03 儿童医院 基于pfcsp的免疫原及其相关组合物和方法
WO2025093541A1 (en) 2023-10-31 2025-05-08 Ose Immunotherapeutics Combination of interleukin 7 and tumour associated antigen vaccine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69435292D1 (de) * 1993-03-05 2010-06-17 Epimmune Inc Verfahren zur herstellung von immunogenen hla-a2.1-bindenden peptiden
WO1995007707A1 (en) * 1993-09-14 1995-03-23 Cytel Corporation Alteration of immune response using pan dr-binding peptides

Also Published As

Publication number Publication date
PT876398E (pt) 2002-12-31
BR9710404A (pt) 1999-08-17
WO1997026784A1 (en) 1997-07-31
DK0876398T3 (da) 2002-08-12
JP2000504328A (ja) 2000-04-11
CA2242878C (en) 2010-06-22
DE69714011T2 (de) 2003-02-27
AU1582797A (en) 1997-08-20
ATE220687T1 (de) 2002-08-15
CN1214051A (zh) 1999-04-14
CA2242878A1 (en) 1997-07-31
EP0876398A1 (en) 1998-11-11
EP0876398B1 (en) 2002-07-17
ES2177927T3 (es) 2002-12-16
DE69714011D1 (de) 2002-08-22

Similar Documents

Publication Publication Date Title
US6413935B1 (en) Induction of immune response against desired determinants
JP4063879B2 (ja) 所望の決定基に対する免疫応答の誘導
JP3926839B2 (ja) 万能dr−結合性ペプチドを用いる免疫応答の改変
EP1917970B1 (en) Hla binding peptides and their uses
US7252829B1 (en) HLA binding peptides and their uses
EP0907370B1 (en) Hla-a2.1 binding peptides and their uses
JP2001511132A (ja) 広範な反応性のdr制限されたエピトープの同定
CA2248657A1 (en) Peptides with increased binding affinity for hla molecules
US20020098197A1 (en) Hla binding peptides and their uses
JP5792630B2 (ja) Pan−dr結合ポリペプチドおよびその使用
US20050049197A1 (en) Induction of immune response against desired determinants
US20020177694A1 (en) Hla binding peptides and their uses
US20090317412A1 (en) Induction of an immune response against streptococcus pneumoniae polyaccharides
EP1619207A2 (en) HLA-A2.1 binding peptides derived from HCV and their uses
EP1320377B1 (en) Hla binding peptides and their uses
US8877914B2 (en) Compositions comprising nucleic acids encoding HIV-1 reverse transcriptase CTL epitopes
EP1767542B1 (en) HLA-A2.1 binding peptides and their uses
AU4754899A (en) HLA Binding peptides and their uses
JP2010001303A (ja) Hla結合ペプチド及びその使用

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20040123

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20040123

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20070116

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20070416

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20070611

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070717

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20071211

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20071226

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20110111

Year of fee payment: 3

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20110111

Year of fee payment: 3

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120111

Year of fee payment: 4

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130111

Year of fee payment: 5

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130111

Year of fee payment: 5

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term