JP3874304B1 - Safety cabinet system, clean bench system, safety cabinet, and clean bench - Google Patents

Abstract

PROBLEM TO BE SOLVED: To record operation contents and externally communicate without causing cross contamination or reduction in work efficiency.
A safety cabinet 72 for handling an operation object in a clean environment and a server 44 connected to the safety cabinet via a communication line are provided. The safety cabinet 72 includes a control unit 100, a display unit 120 that displays at least one of a standard work procedure or a standard protocol that indicates a standard operation content and an operation procedure executed in the safety cabinet, and an operator. The microphone 130 and the foot pedal 131 that receive the input of the operation information are provided. The operation information input by the operator is transmitted to the server 44 and stored. A clean bench may be used instead of the safety cabinet.
[Selection] Figure 4

Description

  The present invention relates to a safety cabinet system, a clean bench system, a safety cabinet, and a clean bench, and more particularly, a safety cabinet system, a clean bench system, and a safety cabinet system for improving the operation level in the safety cabinet and the clean bench and the management level of the operation content. The present invention relates to a safety cabinet and a clean bench.

Patent Document 1 describes a safety cabinet provided with an alarm device for preventing the occurrence of biohazards due to microorganisms operated in the safety cabinet. When performing operations in the work space in the safety cabinet, the operator usually wears rubber gloves and performs necessary operations such as culture and experiments in order to prevent infection with microorganisms.
JP-A-6-241519

  In the conventional safety cabinet including Patent Document 1, since all operations are performed manually (manual), it is necessary to wear rubber gloves for safety. Therefore, when performing operations that deviate from standard protocols that define standard work procedures, operating conditions, and situations such as cell processing performed in the work space of the safety cabinet, the operator must use hand-written rubber gloves. It was necessary to fill in the record. In addition, in order to communicate with an external quality manager, it is necessary to leave the safety cabinet once and perform external communication in an environment where the cleanliness is lower than in the work space of the safety cabinet. As a result, there are problems such as cross-contamination and reduced work efficiency.

  The present invention has been made in view of the above problems, and an object thereof is to provide a safety cabinet system and a safety cabinet capable of recording operation contents and externally communicating without causing cross contamination or a reduction in work efficiency. To do.

  To achieve the above object, a safety cabinet system according to the present invention includes a safety cabinet for handling an operation object under negative pressure, and is connected to the safety cabinet via a communication line and is isolated from the safety cabinet. A safety cabinet system including an information management device installed at a place, and a control for displaying a standard work procedure or a standard protocol indicating a standard operation content and work procedure executed in the safety cabinet. Control means for performing, display means for displaying the standard work procedure or standard protocol according to the control of the control means, input means for accepting input of operation information from an operator operating in the safety cabinet, and the operation information Communication means for performing bidirectional communication between the information management device and the safety cabinet; Characterized in that it comprises.

  The safety cabinet is attached to a storage container that stores the operation target object, and the safety cabinet relates to the operation target object from a two-dimensional barcode or a wireless tag in which information about the operation target object stored in the storage container is recorded. The information processing apparatus may further include a bar code reader or a wireless tag reader for reading information, and the control unit may cause the display unit to display the standard work procedure or the standard protocol based on the read information regarding the operation target.

  The input means includes a microphone for inputting operation information by the operator's voice and a voice recognition means for recognizing the voice inputted from the microphone and converting it into character information, or the operator operates with a foot. It may be configured by a foot pedal for inputting operation information.

  Further, the input means accepts input of executed information indicating that the operation content displayed on the display means has been executed, and the control means displays the executed operation content based on the executed information. You may display on the said display means using the display mode different from the operation content which is not performed.

  Further, the information management device has a deviating operation procedure or deviating protocol indicating operation contents deviating from the standard operating procedure or standard protocol, and the input means is configured such that the operator operates the standard operating procedure or the standard protocol. When an operation deviating from the above is performed, an input of deviating operation information indicating the deviating operation content is received, and the information management device is configured to deviate operation procedure or deviating protocol corresponding to the deviating operation content based on the deviating operation information. May be extracted and transmitted to the safety cabinet, and the display means may display the received departure operation procedure or departure protocol.

  Moreover, you may further provide the two-way call means for the said operator to perform a two-way call with the person located in the place away from the said safety cabinet.

  The information management device may record and manage operation information from the safety cabinet received via the communication unit.

Moreover, this invention is a clean bench system characterized by using the clean bench for handling an operation target object under a positive pressure instead of the safety cabinet as described in any one of Claims 1 thru | or 5. .

  The best mode for carrying out the present invention will be described below with reference to the accompanying drawings.

<First embodiment>
FIG. 1 is an overall configuration diagram of a regenerative medical system using cells in which a safety cabinet system according to the present invention is employed.

  A medical institution 28 (or research institution) such as a hospital collects cells from a human. The collected cells are stored in a predetermined storage container 12 and conveyed to the cell processing center 20.

  A cell processing center 20 (CPC: Cell Processing Center, hereinafter, also simply referred to as “CPC”) accepts cells collected from a human in a medical institution 28 in a state of being accommodated in a predetermined container 12, This is an organization that performs a series of processes such as inspection, cell processing (separation, differentiation induction, proliferation, etc.), culture, storage, inspection, and shipping.

  The inspection center 29 is an organization that performs virus inspection, DNA inspection, and other inspections. Although it is installed outside the medical institution 28 in FIG. 1, it may be provided inside the medical institution 28 as one institution of the medical institution 28.

  Further, the medical institution 28 performs a transplantation operation on the patient using the cells processed by the cell processing center 20. Here, transplantation includes transplantation to a human from which cells are collected (so-called autotransplantation) and transplantation to a human different from the human from which cells are collected (so-called allogeneic transplantation).

  The cell processing center 20 is provided with an acceptance inspection room 21, a cell processing room 22, a cell culture room 23, a storage room 24, an inspection packing room 25, and a central monitoring room 26. The receiving inspection room 21 receives cells collected from a living body at the medical institution 28 and performs an receiving inspection. In the receiving inspection room 21, an inspection terminal 71 for inputting the result of the receiving inspection is installed. The cell processing chamber 22 is provided with a safety cabinet 72 that maintains a sterile condition, and separates specific cells from cells that have passed the acceptance test, and induces differentiation from specific cells into cells of the necessary tissue (differentiated cells). Growth, other cell processing is performed in the safety cabinet 72. An incubator (incubator) 73 for culturing cells is installed in the cell culture chamber 23, and the cells are cultured in the incubator 73. The storage chamber 24 is provided with a storage 74 for freezing and storing the cultured cells. The inspection packing room 25 is a place where the cells to be shipped are inspected and the container 12 for shipping is packed. In the central monitoring room 26, a database 42, a server 44, and a computer terminal 51 are installed.

  In the cell processing center 20, between the receiving inspection chamber 21 and the cell processing chamber 22, between the cell processing chamber 22 and the cell culture chamber 23, and between the cell culture chamber 23, the storage chamber 24, and the inspection packing chamber 25. In between, pass boxes 61, 62, and 63 are provided for delivering the storage container 12 containing cells.

  A wireless tag 11 having a wireless communication function and a storage function is attached to a storage container 12 that stores cells. The wireless tag 11 has a standard operation that prescribes identification information that can uniquely identify a cell accommodated in the container 12, conditions and conditions of the cell treatment, standard operation contents of the cell treatment, and an execution order thereof. A procedure manual (hereinafter referred to as “SOP”) or a standard protocol is stored. Instead of the wireless tag 11, a standard protocol and SOP information may be written on a printed two-dimensional barcode or μ chip, and the information may be read.

  The medical institution 28 and the examination center 29 include computer terminal devices 52 and 53. The process of writing the tag information to the wireless tag 11 is performed in the medical institution 28 and the inspection center 29, and the tag information to be written to the wireless tag 11 is stored and managed in the computer terminal devices 52 and 53, and each section of the cell processing center 20 is managed. The tag information may be written in the wireless tag 11 in the receiving inspection room 21 of the cell processing center 20.

  In addition, the receiving inspection chamber 21, the safety cabinet 72 of the cell processing chamber 22, the incubator 73 of the cell culture chamber 23, the storage chamber 24, the inspection packing chamber 25, and the pass boxes 61, 62, 63 are attached to the storage container 12. Wireless tag readers 31, 32, 33, 34, 35, 36, 37, and 38 that perform wireless communication with the wireless tag 11 are installed. That is, the wireless tag readers 31 to 38 are arranged at each device where the container 12 containing the cells is installed, each device through which the container 12 passes, and other points where the container 12 is handled.

  The wireless tag readers 31 to 38, the database 42 of the central monitoring room 26, the server 44, the computer terminal 51, and the inspection terminal 71 of the receiving inspection room 21 are connected to a LAN (Local Area Network) 90 and can communicate with each other. It is configured. An interphone switching device 94 is connected to the LAN 90, and a PBX 95 is connected to the interphone switching device 94.

  When accessing the server 44 from the computer terminal 51 of the central monitoring room 26, a USB (Universal Serial Bus) key 511 is inserted into the USB port of the computer terminal 51 and a predetermined program is started to input predetermined authentication information. Otherwise, the server 44 cannot be accessed. In other words, the server 44 can be accessed only by a person who has inserted the correct physical key (USB key) and has correctly entered the authentication information, thereby eliminating the third party's access.

  The database 42 manages the processing schedule and progress status for the cells, the examination results, the history of reading the cell ID from the wireless tag 11 of the container 12 by the wireless tag readers 31 to 38, and other information related to regenerative medicine. Also, a deviating protocol that defines operating conditions and situations different from the standard protocol and a deviating operation procedure that indicates the execution order of the deviating operation contents are stored. The departure protocol and the departure operation procedure are stored in association with a keyword indicating the departure operation and the situation.

  The server 44 includes an inspection terminal 71 in the receiving inspection room 21, an inspection terminal in the cell processing chamber 22 (not shown), an inspection terminal in the cell culture chamber 23 (not shown), and an inspection terminal in the inspection packing room 25 (not shown). ), Communicates with the computer terminal 51 of the central monitoring room 26, the wireless tag readers 31 to 38, and other various devices, and schedules and progress of processing for the cells, executed information received from the safety cabinet 72, and the operator Operation information, test results, cell ID readings, and other information related to regenerative medicine input from the pedal 131 are collected and registered in the database 42. The server 44 complies with the regulations (eg, 21 CFR PART11) regarding electronic records and electronic signatures of application documents to the FDA (US Food and Drug Administration), FDA compatible software for recording and signing CPC processing results, The voice recognition software that recognizes the voice information received from the cabinet 72 and outputs the character recognition information, and the database 42 is searched based on the character recognition information output by the voice recognition software, the deviation protocol is searched and transmitted to the safety cabinet 72. Search software is stored and these software are executed.

  When the server 44 receives an information request from the computer terminal 51, the server 44 performs authentication, edits the information managed in the database 42, and provides the requested information to the computer terminal 51. It is like that.

  In the present embodiment, the server 44 controls separation, differentiation induction, culture, storage, shipment, and other processes performed on the cells based on the result of the cell inspection.

  FIG. 2 is a schematic configuration diagram of the safety cabinet 72 installed in the cell processing chamber 22. The safety cabinet 72 can open and close the work space 171 by moving up and down the housing 170 for handling the operation target under negative pressure, the work space 171 inside the housing 170, and installed on the front surface of the housing 170. The opening / closing part 172, the opening part 173 in which the work space 171 and the outer space of the safety cabinet 72 communicate with each other, and the HEPA filter (ultra-high performance air filter) 174 for purifying the air in the work space 171 are provided. Furthermore, the surface that constitutes the work space 171 and that faces the operator who operates using the safety cabinet 72 is provided with a display unit 120 for displaying SOP and standard protocols. In addition, a control unit 100 that controls the operation of the safety cabinet 72 is provided inside the housing 170. The operator wears the microphone 130 and the earphone 121 and operates the foot pedal 131.

  FIG. 3 is a block diagram illustrating a configuration of the control unit 100 of the safety cabinet 72. The control unit 100 mainly includes a central processing unit (CPU) 101 that controls the operation of each component and a display unit interface (hereinafter referred to as “I / F”) for connecting a display unit 120 including a liquid crystal monitor that displays an image. 104, an earphone I / F 105 for connecting an earphone 121 to output a sound signal, a microphone I / F 106 for connecting a microphone 130 and receiving an input of a sound signal from the microphone 130, and a foot pedal Pedal 1 / F107 which receives the input signal from 131, Communication I / F109 for connecting to LAN90 in CPC, and the bus | bath 110 for connecting each said component are provided. In the above description, the microphone 130 and the foot pedal 131 are provided as input means, but the input means is not limited to this. Further, the safety cabinet 72 may be provided with an input means by manual operation such as a keyboard or a trackball. However, an input means that does not involve manual operation at the time of input is preferable in that manual operation is not interrupted. A viewpoint tracer that detects and inputs the viewpoint position may be used.

  Next, the processing flow of the safety cabinet system will be described with reference to FIGS. FIG. 4 is a schematic diagram showing an outline of an information system of the safety cabinet system according to the present embodiment. FIG. 5 is a flowchart showing a process flow of the safety cabinet system. FIG. 6 is a schematic diagram illustrating an example of a display screen that displays the SOP and the standard protocol. FIG. 7 is a schematic diagram illustrating an example of a display screen on which the deviating operation procedure and the deviating operation protocol are displayed. FIG. 8 is a screen display example displaying external contacts.

  As shown in FIG. 4, the safety cabinet 72 installed in the cell processing chamber 22 is connected to the server 44 and the computer terminal 51 installed in the central monitoring chamber 26 via the LAN 90. Information input by the operator operating the safety cabinet 72 using the microphone 130 and the foot pedal 131 is transmitted to the server 44 and the computer terminal 51 via the LAN 90. A voice signal input from the microphone 130 is converted into character information by the computer terminal 51 or voice recognition software of the control unit 100, and a search request of the database 42 and a search result are received based on the character information. Furthermore, an interphone switching device 94 is connected to the LAN 90, and bidirectional communication between an operator wearing the microphone 130 and the earphone 121 and a person located outside the central monitoring room 26 and the CPC can be performed. Hereinafter, the process flow of the safety cabinet system will be described in the order of steps in FIG.

  In S1, the wireless tag reader 33 of the safety cabinet 72 reads tag information from the wireless tag 11 attached to the specimen storage container 12 (S1). The wireless tag 11 stores standard protocol information such as conditions and conditions indicating the operation content of the sample stored in the storage container 12 in advance, and SOP information indicating the operation procedure.

  In S2, the server 44 receives input of tag information from the wireless tag reader 33, and displays the standard protocol and SOP on the display unit 120 (S2). As shown in FIG. 6, in the procedure display area 121 of the display unit 120, three operations to be performed by the operator in the work space 171 of the safety cabinet 72, the operation contents of the operation 1, the operation 2, and the operation 3 are the operation procedures. It is displayed along. The operation 1 is displayed by using a display mode (for example, changing the display color) different from the operations 2 and 3 that are not executed or being executed in order to indicate that the operation 1 has already been executed. In the protocol display area 122 of the display unit 120, standard protocols such as operation conditions 1 and 2 of the operation 2 currently performed by the operator are displayed. In the protocol display area 122, an explanation image 123 for explaining the situation of the operation 2 may be displayed. Further, the lower column of the display unit 120 displays the result of voice recognition processing performed on voice information input from the microphone 130 by the operator and converted into character information. In the voice recognition processing, voice information may be transmitted to the server 44 or the computer terminal 51, converted into character information by voice recognition software installed in the server 44 or the computer terminal 51, and the character information may be received. In addition, when voice recognition software is installed in the control unit 100, the control unit 100 may perform this.

  In S3, it is determined whether or not the content and status of the operation to be performed by the operator are defined in the SOP and standard protocol displayed on the display unit 120 (S3). If "NO", the process proceeds to S6.

  In S <b> 4, the operator performs an operation according to the SOP and the standard protocol, and inputs executed information by depressing the foot pedal 131. Or you may utter and input that it has been performed from the microphone 130. In S <b> 5, when the control unit 100 receives input of executed information, the control unit 100 changes the display mode of the operation executed on the display unit 120, for example, the operation 1. The executed information and the operation information are transmitted and recorded in the database 42 from the safety cabinet 72.

  In S6, the operator makes a search request for a departure protocol and a departure operation procedure (S6). The operator utters a word as a keyword for explaining the deviated situation and inputs it from the microphone 130. The input voice information is converted into character information by any voice recognition software of the control unit 100, the server 44, or the computer terminal 51. The server 44 searches the database 42 based on the converted character information, and extracts a deviation operation procedure and a deviation protocol corresponding to the character information. And it transmits to the control part 100 of the safety cabinet 72. The character information is displayed in the voice input information display area 124 and can be visually recognized by the operator.

  In S <b> 7, the departure operation procedure and departure operation protocol received by the control unit 100 are displayed on the display unit 120. FIG. 7 is a screen display example displayed in this step. The display unit 120 displays deviation operations A1, A2, and A3 according to the operation procedure. Also, the protocol of the departure operation A1 is displayed.

  In S8, it is determined whether or not the problem has been solved by the departure operation procedure and departure protocol displayed in S7. If “YES”, the process proceeds to S10, and if “NO”, the process proceeds to S9.

  In S9, the operator selects a desired contact and communicates with the outside of the cell processing chamber 22 (S9). FIG. 8 is a screen display example for selecting a call partner. When the operator depresses the foot pedal 131 twice in succession or utters and inputs a request to display a contact from the microphone 130, the screen of the display unit 120 transitions from FIG. 7 to FIG. . In FIG. 8, the other party that the operator is supposed to contact is displayed. The operator continues to depress the foot pedal 131 and moves the selection cursor 125 to a desired destination position. Then, when a foot is spoken from the foot pedal 131, the other party is selected. When the foot pedal 131 is depressed again, a call request is made to the other party. The interphone switching device 94 is connected to the PBX if it is inside the CPC, and is connected to a general telephone line if it is outside the CPC.

  In S10, it is determined whether all the operations in the safety cabinet 72 have been processed. If “YES”, the process ends. If “NO”, the process returns to S3 to perform the next operation.

  According to the present embodiment, the SOP and the standard protocol are displayed on the display unit 120 provided in the safety cabinet 72, and the operator can perform an operation while visually recognizing the SOP and the standard protocol. Thereby, an operation mistake can be prevented. Furthermore, execution information indicating that the operation has been executed is input by a simple operation such as uttering or stepping on the foot pedal 131, and the input result is stored in the database 42, thereby easily and reliably recording the execution operation. Can do. In addition, even when a situation deviates from the SOP and the standard protocol, it is possible to search and extract the operation procedure and protocol of the deviating operation and to make external communication without leaving the safety cabinet 72. Inefficiencies due to interruptions can be eliminated.

<Other embodiments>
In the first embodiment, the SOP and the standard protocol are stored in the wireless tag 11, but the identification information of the specimen is stored in the wireless tag 11, and the standard protocol corresponding to the identification information is stored in the database 42. Tag information may be transmitted from the communication I / F 109 to the server 44 to search for a standard protocol.

  In the first embodiment, the safety cabinet 72 includes the control unit 100. However, the safety cabinet 72 does not include the control unit 100, and the display control of the display unit 120 and the input processing from the microphone 130 and the foot pedal 131 are performed. May be controlled by the computer terminal 51 of the central monitoring room 26. FIG. 9 shows a schematic diagram of the information system in this embodiment. The wireless tag reader 33 is connected to the LAN 90 and transmits the read tag information to the computer terminal 51. Then, the computer terminal 51 determines the SOP and standard protocol to be displayed based on the tag information. Next, the computer terminal 51 transmits display data to the display unit 120 via the LAN 90. Further, the computer terminal 51 changes the display mode of the operation content that has already been executed based on the input information from the microphone 130 or the foot pedal 131 and performs search / display processing for the departure operation procedure or departure protocol.

  Moreover, in the said embodiment, although the safety cabinet for culturing the cell extract | collected from the living body was taken as an example, the safety cabinet for isolating and handling the sample which consists of microorganisms, such as a virus and bacteria, and the safety cabinet for handling a chemical | drug | medicine It can also be applied to.

  Moreover, although the said embodiment demonstrated using the safety cabinet 72 which handles an operation target under negative pressure, you may use the clean bench which handles an operation target under positive pressure instead of the safety cabinet 72.

1 is an overall configuration diagram of a cell management system according to an embodiment of the present invention. Schematic configuration diagram of safety cabinet 72 The block diagram which shows the structure of the control part 100 of the safety cabinet 72 Schematic diagram showing an overview of the information system of the safety cabinet system of the first embodiment Flow chart showing the flow of processing of the safety cabinet system Schematic diagram showing an example of a display screen displaying SOP and standard protocol Schematic diagram showing an example of a display screen displaying the deviating operation procedure and deviating operation protocol Schematic diagram showing a screen display example showing external contacts Schematic diagram showing an overview of the information system of the safety cabinet system of the second embodiment

Explanation of symbols

  DESCRIPTION OF SYMBOLS 11 ... Wireless tag, 12 ... Container, 20 ... Cell processing center (CPC), 21 ... Acceptance inspection room, 22 ... Cell processing room, 23 ... Cell culture room, 24 ... Storage room, 25 ... Inspection packing room, 26 ... Central monitoring room, 28 ... medical institution, 29 ... inspection center, 31 to 38 ... wireless tag reader, 42 ... database, 44 ... server, 51, 52, 53 ... computer terminal, 511 ... USB key, 61, 62, 63 ... pass Box, 72 ... Safety cabinet, 73 ... Incubator, 74 ... Storage, 90 ... Local area network (LAN), 91 ... Internet

Claims (6)

A safety cabinet system comprising: a safety cabinet for handling an operation object under negative pressure; and an information management device connected to the safety cabinet via a communication line and installed in a place isolated from the safety cabinet. There,
A barcode reader that is attached to a storage container that stores the operation target, and that reads information about the operation target from a two-dimensional barcode or wireless tag in which information about the operation target stored in the storage container is recorded, or A wireless tag reader;
A control means for performing control to display a standard work procedure or a standard protocol indicating a standard operation content and work procedure executed in the safety cabinet based on the information on the read operation object ;
Display means for displaying the standard work procedure or standard protocol in accordance with the control of the control means;
Input means for receiving input of operation information including executed information indicating that at least the operation content displayed on the display means has been executed from an operator who performs an operation in the safety cabinet, the voice of the operator And a voice recognition means for recognizing and converting voice input from the microphone into character information, or a foot pedal for operating the operator with his / her foot to input the operation information Input means ,
Communication means for performing bidirectional communication between the information management device and the safety cabinet, the operation information ,
The control means causes the display means to display the operation contents that have been executed based on the executed information on the display means using a display mode different from the operation contents that have not been executed . A safety cabinet system comprising: a safety cabinet for handling an operation object under negative pressure; and an information management device connected to the safety cabinet via a communication line and installed in a place isolated from the safety cabinet. There,
A control means for performing control to display a standard operation procedure or a standard protocol indicating a standard operation content and a work procedure to be executed in the safety cabinet;
Display means for displaying the standard work procedure or standard protocol in accordance with the control of the control means;
The executed information indicating that at least the operation content displayed on the display means has been executed from the operator who operates in the safety cabinet, and the operation that the operator deviates from the standard operation procedure or the standard protocol. Input means for receiving operation information including deviating operation information indicating the deviating operation content when performing, a microphone for inputting operation information by the operator's voice, and a voice input from the microphone; Voice recognition means for recognizing and converting to character information, or input means constituted by a foot pedal for the operator to input operation information by operating with a foot;
Communication means for performing two-way communication between the information management device and the safety cabinet, the operation information,
The control means causes the display means to display the operation contents that have been executed based on the executed information on the display means using a display mode different from the operation contents that have not been executed.
The information management device has a deviating operation procedure or deviating protocol indicating operation contents deviating from the standard operating procedure or standard protocol, and corresponds to the deviating operation contents based on deviating operation information from the input means. Extract the deviating operation procedure or deviating protocol and send it to the safety cabinet;
The display means displays the received deviation operation procedure or deviation protocol.
A safety cabinet system characterized by that. A safety cabinet system comprising: a safety cabinet for handling an operation object under negative pressure; and an information management device connected to the safety cabinet via a communication line and installed in a place isolated from the safety cabinet. There,
A barcode reader that is attached to a storage container that stores the operation target, and that reads information about the operation target from a two-dimensional barcode or wireless tag in which information about the operation target stored in the storage container is recorded, or A wireless tag reader;
A control means for performing control to display a standard work procedure or a standard protocol indicating a standard operation content and work procedure executed in the safety cabinet based on the information on the read operation object;
Display means for displaying the standard work procedure or standard protocol in accordance with the control of the control means;
The executed information indicating that at least the operation content displayed on the display means has been executed from the operator who operates in the safety cabinet, and the operation that the operator deviates from the standard operation procedure or the standard protocol. Input means for receiving operation information including deviating operation information indicating the deviating operation content when performing, a microphone for inputting operation information by the operator's voice, and a voice input from the microphone; Voice recognition means for recognizing and converting to character information, or input means constituted by a foot pedal for the operator to operate and input operation information;
Communication means for performing bidirectional communication between the information management device and the safety cabinet, the operation information,
The control means causes the display means to display the operation content that has been executed based on the executed information using a display mode different from the operation content that has not been executed,
The information management device has a deviating operation procedure or deviating protocol indicating operation contents deviating from the standard operating procedure or standard protocol, and corresponds to the deviating operation contents based on deviating operation information from the input means. Extract the deviating operation procedure or deviating protocol and send it to the safety cabinet;
The display means displays the received deviation operation procedure or deviation protocol.
A safety cabinet system characterized by that. The apparatus further comprises a two-way communication means for the operator to perform a two-way call with a person located away from the safety cabinet.
The safety cabinet system according to any one of claims 1 to 3 . The information management apparatus, safety cabinet system according to any one of claims 1 to 4, characterized in that the recording management operation information from the safety cabinet received via the communication means. A clean bench system for using a clean bench for handling an operation object under positive pressure instead of the safety cabinet according to any one of claims 1 to 5 .

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