JP3618759B2 - 電気化学発光性酵素バイオセンサー - Google Patents

電気化学発光性酵素バイオセンサー Download PDF

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Publication number
JP3618759B2
JP3618759B2 JP50205997A JP50205997A JP3618759B2 JP 3618759 B2 JP3618759 B2 JP 3618759B2 JP 50205997 A JP50205997 A JP 50205997A JP 50205997 A JP50205997 A JP 50205997A JP 3618759 B2 JP3618759 B2 JP 3618759B2
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Prior art keywords
enzyme
nad
oxidoreductase
dehydrogenase
complex
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Expired - Fee Related
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JP50205997A
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English (en)
Japanese (ja)
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JPH11507536A5 (enExample
JPH11507536A (ja
Inventor
ティー． マーチン，マーク
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イゲン，インコーポレイテッド
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Plasma & Fusion (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Luminescent Compositions (AREA)
JP50205997A 1995-06-06 1996-06-06 電気化学発光性酵素バイオセンサー Expired - Fee Related JP3618759B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/467,712 US6852502B1 (en) 1995-06-06 1995-06-06 Electrochemiluminescent enzyme biosensors
US08/467,712 1995-06-06
PCT/US1996/009869 WO1996039534A1 (en) 1995-06-06 1996-06-06 Electrochemiluminescent enzyme biosensors

Publications (3)

Publication Number Publication Date
JPH11507536A JPH11507536A (ja) 1999-07-06
JPH11507536A5 JPH11507536A5 (enExample) 2004-07-29
JP3618759B2 true JP3618759B2 (ja) 2005-02-09

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP50205997A Expired - Fee Related JP3618759B2 (ja) 1995-06-06 1996-06-06 電気化学発光性酵素バイオセンサー

Country Status (8)

Country Link
US (1) US6852502B1 (enExample)
EP (1) EP0837949B1 (enExample)
JP (1) JP3618759B2 (enExample)
AT (1) ATE254186T1 (enExample)
AU (1) AU698465B2 (enExample)
CA (1) CA2223017A1 (enExample)
DE (1) DE69630688T2 (enExample)
WO (1) WO1996039534A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023075465A1 (ko) * 2021-10-27 2023-05-04 한국전기연구원 광열 모듈레이션 레이저 스펙클 영상을 이용한 포도당 농도 측정 시스템, 방법, 및 상기 방법을 실행시키기 위한 컴퓨터 판독 가능한 프로그램을 기록한 기록 매체

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010003647A1 (en) * 1995-06-07 2001-06-14 Ji Sun Coreatant-including electrochemiluminescent compounds, methods, systems and kits utilizing same
US6673533B1 (en) 1995-03-10 2004-01-06 Meso Scale Technologies, Llc. Multi-array multi-specific electrochemiluminescence testing
CN1192097C (zh) * 1995-03-10 2005-03-09 梅索磅秤技术有限公司 多阵列、多特异性的电化学发光检验
US6140045A (en) * 1995-03-10 2000-10-31 Meso Scale Technologies Multi-array, multi-specific electrochemiluminescence testing
US6319670B1 (en) 1995-05-09 2001-11-20 Meso Scale Technology Llp Methods and apparatus for improved luminescence assays using microparticles
US6724309B2 (en) 2000-11-03 2004-04-20 Excel Corporation Method and apparatus for tracking carcasses
US7766730B2 (en) 2000-11-03 2010-08-03 Cargill, Incorporated Carcass tracking
US7400256B2 (en) 2000-11-03 2008-07-15 Cargill, Incorporated Chill cooler storage and selection system
EP1522592B1 (en) 2002-06-17 2008-08-06 ARKRAY, Inc. Glucose sensor with the use of glucose dehydrogenase
CA2609379C (en) * 2005-06-03 2016-11-29 Allen J. Bard Electrochemistry and electrogenerated chemiluminescence with a single faradaic electrode
DE602006020158D1 (de) 2005-11-08 2011-03-31 Surmodics Inc Ultradünne photopolymer-beschichtungen und verwendungen davon
JP2010523084A (ja) 2007-03-30 2010-07-15 アンブルックス，インコーポレイテッド 修飾ｆｇｆ−２１ポリペプチド
US8008037B2 (en) * 2008-03-27 2011-08-30 Roche Diagnostics Operations, Inc. Matrix composition with alkylphenazine quaternary salt and a nitrosoaniline
KR101603354B1 (ko) 2008-04-11 2016-03-14 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 나노입자 전기발생 화학발광 증폭 방법 및 시스템
EP2294387B1 (en) 2008-05-08 2017-08-23 Board of Regents of the University of Texas System Luminescent nanostructured materials for use in electrogenerated chemiluminescence
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
US9075042B2 (en) 2012-05-15 2015-07-07 Wellstat Diagnostics, Llc Diagnostic systems and cartridges
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
CN107108710B (zh) 2014-10-24 2022-02-15 百时美施贵宝公司 修饰的fgf-21多肽及其用途
PL3338094T3 (pl) 2015-08-20 2019-09-30 F. Hoffmann-La Roche Ag Test immunologiczny oparty na cząstkach z zastosowaniem pegylowanego swoistego względem analitu czynnika wiążącego
CN108780092A (zh) 2016-03-07 2018-11-09 豪夫迈·罗氏有限公司 抗p53抗体的检测
WO2018141768A1 (en) 2017-02-02 2018-08-09 Roche Diagnostics Gmbh Immunoassay using at least two pegylated analyte-specific binding agents
WO2019201901A1 (en) 2018-04-18 2019-10-24 F. Hoffmann-La Roche Ag Novel anti-thymidine kinase antibodies
EP3844503B1 (en) 2018-08-31 2024-05-29 F. Hoffmann-La Roche AG Thymidine kinase (tk-1) in prognostic indices for dlbcl
CN110938667A (zh) * 2018-09-21 2020-03-31 中国科学院天津工业生物技术研究所 一种酶电极、生物传感器及其制备方法和用途
WO2021013781A1 (en) 2019-07-22 2021-01-28 F. Hoffmann-La Roche Ag Substance p as blood biomarker for the non-invasive diagnosis of endometriosis
WO2021013783A1 (en) 2019-07-22 2021-01-28 F. Hoffmann-La Roche Ag S100a12 as blood biomarker for the non-invasive diagnosis of endometriosis
WO2021013786A1 (en) 2019-07-22 2021-01-28 F. Hoffmann-La Roche Ag S100a6 as blood biomarker for the non-invasive diagnosis of endometriosis
BR112022000172A2 (pt) 2019-07-22 2022-02-22 Hoffmann La Roche Métodos para avaliar se uma paciente tem endometriose, para selecionar uma paciente para terapia e para monitorar uma paciente
KR20220024782A (ko) 2019-07-22 2022-03-03 에프. 호프만-라 로슈 아게 자궁내막증의 비침습적 진단을 위한 혈액 바이오마커로서의 s100a8
BR112022009371A2 (pt) 2019-11-15 2022-08-09 Hoffmann La Roche Métodos para determinar a quantidade ou concentração de um ou mais analitos antibióticos, tubos de amostragem, usos de um reagente de derivatização nucleofílica e analito antibiótico
EP4237441A1 (en) 2020-11-02 2023-09-06 F. Hoffmann-La Roche AG Sars-cov-2 nucleocapsid antibodies
WO2022207628A1 (en) 2021-03-30 2022-10-06 F. Hoffmann-La Roche Ag Scf as blood biomarker for the non-invasive diagnosis of endometriosis
WO2022207685A1 (en) 2021-04-01 2022-10-06 F. Hoffmann-La Roche Ag Psp94 as blood biomarker for the non-invasive diagnosis of endometriosis
US20240272177A1 (en) 2021-05-17 2024-08-15 Roche Diagnostics Operations, Inc. sFRP4 AS BLOOD BIOMARKER FOR THE NON-INVASIVE DIAGNOSIS OF ADENOMYOSIS
JP2024541945A (ja) 2021-10-26 2024-11-13 エフ． ホフマン－ラ ロシュ アーゲー ＳＡＲＳ－ＣｏＶ－２受容体結合ドメイン抗体
WO2023131594A1 (en) 2022-01-05 2023-07-13 F. Hoffmann-La Roche Ag Derivatization of compounds in patient samples for therapeutic drug monitoring (tdm)
WO2023247752A1 (en) 2022-06-23 2023-12-28 F. Hoffmann-La Roche Ag Method for diagnosing endometriosis and for classifying the stage of endometriosis
CN119585618A (zh) 2022-07-22 2025-03-07 豪夫迈·罗氏有限公司 成纤维细胞生长因子结合蛋白1(fgfbp1)作为（血液）生物标志物用于诊断多囊卵巢综合征
CN119604768A (zh) 2022-07-22 2025-03-11 豪夫迈·罗氏有限公司 白三烯a4水解酶(lta4h)作为（血液）生物标志物用于诊断多囊卵巢综合征
CN119585617A (zh) 2022-07-22 2025-03-07 豪夫迈·罗氏有限公司 镍纹蛋白样蛋白(metrnl)作为（血液）生物标志物用于诊断多囊卵巢综合征
CN120693408A (zh) 2022-12-05 2025-09-23 直接传感有限公司 非乳酸羟基酸的酶促检测
WO2025017135A1 (en) 2023-07-20 2025-01-23 F. Hoffmann-La Roche Ag Screening methods for antibody compositions
WO2025026908A1 (en) 2023-07-28 2025-02-06 Roche Diagnostics Gmbh Serum epha1 as biomarker for endometriosis

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5310687A (en) 1984-10-31 1994-05-10 Igen, Inc. Luminescent metal chelate labels and means for detection
US5221605A (en) 1984-10-31 1993-06-22 Igen, Inc. Luminescent metal chelate labels and means for detection
US5147806A (en) 1988-04-29 1992-09-15 Igen, Inc. Method and apparatus for conducting electrochemiluminescence measurements
US5250415A (en) 1987-04-08 1993-10-05 Merck Patent Gesellschaft Mit Beschrankter Haftung Process for the preparation of glucose dehydrogenase from Bacillus megaterium
US5061455A (en) 1987-04-30 1991-10-29 United Technologies Corporation Apparatus for removing carbon dioxide from air
US5093268A (en) 1988-04-28 1992-03-03 Igen, Inc. Apparatus for conducting a plurality of simultaneous measurements of electrochemiluminescent phenomena
US5340722A (en) 1988-08-24 1994-08-23 Avl Medical Instruments Ag Method for the determination of the concentration of an enzyme substrate and a sensor for carrying out the method
US5068088A (en) 1988-11-03 1991-11-26 Igen, Inc. Method and apparatus for conducting electrochemiluminescent measurements
US5235808A (en) 1990-02-12 1993-08-17 General Electric Company Exhaust nozzle including idle thrust spoiling
US5324835A (en) 1990-03-30 1994-06-28 Biosensor Laboratories Co., Ltd. Pyridazinoquinoxalinones for use as chemiluminescent agents
US5229202A (en) 1990-05-22 1993-07-20 Mitsubishi Kasei Corporation Carbon fiber and carbon fiber-reinforced resin composition using it
US5264092A (en) 1991-10-02 1993-11-23 Moltech Corporation Redox polymer modified electrode for the electrochemical regeneration of coenzyme
JP2541081B2 (ja) 1992-08-28 1996-10-09 日本電気株式会社 バイオセンサ及びバイオセンサの製造・使用方法
US5527710A (en) * 1994-12-02 1996-06-18 Igen, Inc. Rate measurements of biomolecular reactions using electrochemiluminescence
CN1192097C (zh) * 1995-03-10 2005-03-09 梅索磅秤技术有限公司 多阵列、多特异性的电化学发光检验

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023075465A1 (ko) * 2021-10-27 2023-05-04 한국전기연구원 광열 모듈레이션 레이저 스펙클 영상을 이용한 포도당 농도 측정 시스템, 방법, 및 상기 방법을 실행시키기 위한 컴퓨터 판독 가능한 프로그램을 기록한 기록 매체

Also Published As

Publication number Publication date
WO1996039534A1 (en) 1996-12-12
EP0837949A4 (en) 2000-05-17
ATE254186T1 (de) 2003-11-15
JPH11507536A (ja) 1999-07-06
EP0837949A1 (en) 1998-04-29
AU6382296A (en) 1996-12-24
AU698465B2 (en) 1998-10-29
EP0837949B1 (en) 2003-11-12
CA2223017A1 (en) 1996-12-12
DE69630688D1 (de) 2003-12-18
DE69630688T2 (de) 2004-09-23
US6852502B1 (en) 2005-02-08

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