JP3499882B2 - Disinfectant for viscous rubbing - Google Patents

Description

Detailed Description of the Invention

[0001]

The present invention relates to a disinfectant for viscous rubs,
In particular, the present invention relates to a viscous rubbing disinfectant which is a disinfectant for hands and fingers for all persons such as medical staff, employees of food businesses or restaurants, and people of general households.

[0002]

2. Description of the Related Art Conventionally, as a method of disinfecting hands or fingers, there is a method of diluting a disinfectant with water and putting it in a basin such as a washbasin, and rubbing the hands or fingers in the solution to disinfect.

Apart from this, lower alcohols, especially ethanol, have a strong bactericidal activity and relatively weak skin irritation, and are therefore directly used as finger disinfectants.

However, since lower alcohols are flammable and are dangerous, in order to use the lower alcohols in the basin method without diluting them, it is necessary to decide a specific place and use them with strict caution. I have to.

In order to avoid the above-mentioned danger of disinfection with lower alcohol, it is possible to put the lower alcohol in a container having a small diameter, then put about 3 to 5 ml of the lower alcohol directly on the palm and rub it with the fingers and the palm to disinfect. It is being appreciated. According to this method, since lower alcohol has good volatility, it scatters spontaneously, which is convenient because it does not need to be wiped with a towel.

[0006]

When attempting to disinfect a finger by directly using such a lower alcohol disinfectant, since lower alcohol has a low interfacial tension, it easily spills from between the fingers when it is picked up by the hand, and disinfects the disinfectant. It was difficult to secure the necessary amount, and there were problems such as soiling the floor and sometimes catching fire.

[0007]

DISCLOSURE OF THE INVENTION The present invention comprises a disinfectant containing a lower alcohol as a main component, a carboxyvinyl polymer in a specific ratio, and an organic amine as a pH adjusting agent. It is a disinfectant for viscous rubs that is convenient for use because it has viscosity and does not spill when disinfecting fingers.

As the lower alcohol used in the disinfectant for viscous rubbing according to the present invention, ethanol, isopropanol and the like can be used, but ethanol is most preferable.

Such lower alcohol is 50 to 95% by volume of the total amount of the disinfectant.

As the carboxyvinyl polymer used in the present invention, polymers of acrylic acid, methacrylic acid and their lower ester derivatives can be used. Since these polymers are used to impart viscosity to a disinfectant for rubbing lower alcohols and to adhere to a finger or the like, it is preferable to use viscous liquids. For example, Hibiswako (registered trademark) manufactured by Wako Pure Chemical Industries, Ltd. can be used.

The amount of carboxyvinyl polymer added to the rubbing disinfectant depends on the viscosity of the carboxyvinyl polymer itself used. However, a carboxyvinyl polymer selected for use in advance may be mixed with a lower alcohol so that it will not be spilled between fingers. Therefore, it may be appropriately experimentally determined according to the viscosity of the carboxyvinyl polymer used. In the present invention, for 100 ml of the rubbing disinfectant,
Add in an amount of 1 g. In addition, you may add another thickener and / or a thickening auxiliary agent.

If desired, a small amount of another disinfectant such as benzalkonium chloride, chlorhexidine gluconate, alkyldiaminoglycine, and povidone-iodine may be added to the rubbing disinfectant of the present invention.

If necessary, a conventionally known skin stimulant can be added. Also, the pH
A pH adjusting agent is added to make it as neutral as possible.

When the carboxyvinyl polymer is dissolved only in a mixed liquid of alcohol and water, the pH is usually 2-3.
Carboxyvinyl polymers are not viscous in this pH range. The pH is preferably 5 to 8 in consideration of thickening and further skin irritation. However, when an inorganic basic substance such as KOH is used as the pH adjuster, it becomes less viscous. Therefore, in the present invention, an organic amine such as diisopropanolamine is used. At that time, organic amines having a so-called malodor such as triethylamine are not preferable. Further, triisooctyl glyceride or the like can be added as a skin emollient.

[0015]

[Examples] Representative formulations will be described below with reference to Examples. The appropriate amount of purified water in the examples is the amount required to make the total amount of the disinfectant 100 ml.

Example 1 Prescription 1: in 100 ml of disinfectant               83 ml of ethanol   Thickener Carboxyvinyl Polymer 0.35g   pH adjuster diisopropanolamine 0.20g   Solvent Purified water Appropriate amount

Example 2 Prescription 2: In 100 ml of disinfectant               83 ml of ethanol   Thickener carboxyvinyl polymer 0.25g   Wetting agent hydroxypropyl cellulose               (Molecular weight 2500) 0.25g   Wetting agent polyethylene glycol               (Molecular weight 20000) 0.25g   pH adjuster diisopropanolamine 0.14g   Emollient triisooctyl glyceride 0.2g   Solvent Purified water Appropriate amount

Example 3 Prescription 3: In 100 ml of disinfectant               83 ml of ethanol               Benzalkonium chloride 0.2g   Thickener carboxyvinyl polymer 0.25g   Wetting agent hydroxypropyl cellulose               (Molecular weight 2500) 0.25g   Wetting agent polyethylene glycol               (Molecular weight 20000) 0.25g   pH adjuster diisopropanolamine 0.14g   Emollient triisooctyl glyceride 0.2g   Solvent Purified water Appropriate amount

Example 4 Prescription 4: In 100 ml of disinfectant               83 ml of ethanol               Benzalkonium chloride 0.2g   Thickener Carboxyvinyl Polymer 0.1g   Wetting agent hydroxypropyl cellulose               (Molecular weight 2500) 0.25g   Wetting agent polyethylene glycol               (Molecular weight 20000) 0.25g   pH adjuster diisopropanolamine 0.06g   Emollient triisooctyl glyceride 0.2g   Solvent Purified water Appropriate amount

Example 5 Prescription 5: In 100 ml of disinfectant               83 ml of ethanol               Benzalkonium chloride 0.2g   Thickener Carboxyvinyl Polymer 1.0g   Wetting agent hydroxypropyl cellulose               (Molecular weight 2500) 0.25g   Wetting agent polyethylene glycol               (Molecular weight 20000) 0.25g   pH adjuster Diisopropanolamine 0.7g   Emollient triisooctyl glyceride 0.2g   Solvent Purified water Appropriate amount

Example 6 Prescription 6: In 100 ml of disinfectant               95 ml of ethanol               Benzalkonium chloride 0.2g   Thickener carboxyvinyl polymer 0.25g   Wetting agent hydroxypropyl cellulose               (Molecular weight 2500) 0.25g   Wetting agent polyethylene glycol               (Molecular weight 20000) 0.25g   pH adjuster diisopropanolamine 0.14g   Emollient triisooctyl glyceride 0.2g   Solvent Purified water Appropriate amount

Example 7 Prescription 7: In 100 ml of disinfectant               83 ml of ethanol               Chlorhexidine gluconate 0.2g   Thickener carboxyvinyl polymer 0.25g   Wetting agent hydroxypropyl cellulose               (Molecular weight 2500) 0.25g   Wetting agent polyethylene glycol               (Molecular weight 20000) 0.25g   pH adjuster diisopropanolamine 0.14g   Emollient triisooctyl glyceride 0.2g   Solvent Purified water Appropriate amount

Example 8 Prescription 8: In 100 ml of disinfectant               83 ml of ethanol               Alkyldiaminoglycine 0.2g   Thickener carboxyvinyl polymer 0.25g   Wetting agent hydroxypropyl cellulose               (Molecular weight 2500) 0.25g   Wetting agent polyethylene glycol               (Molecular weight 20000) 0.25g   pH adjuster diisopropanolamine 0.14g   Emollient triisooctyl glyceride 0.2g   Solvent Purified water Appropriate amount

Example 9 Prescription 9: In 100 ml of disinfectant               83 ml of ethanol               Popidone iodine 0.5g   Thickener carboxyvinyl polymer 0.25g   Wetting agent hydroxypropyl cellulose               (Molecular weight 2500) 0.25g   Wetting agent polyethylene glycol               (Molecular weight 20000) 0.25g   pH adjuster diisopropanolamine 0.14g   Emollient triisooctyl glyceride 0.2g   Solvent Purified water Appropriate amount

Example 10 Prescription 10: In 100 ml of disinfectant               50 ml of ethanol               Benzalkonium chloride 0.2g   Thickener carboxyvinyl polymer 0.25g   Wetting agent hydroxypropyl cellulose               (Molecular weight 2500) 0.25g   Wetting agent polyethylene glycol               (Molecular weight 20000) 0.25g   pH adjuster diisopropanolamine 0.14g   Emollient triisooctyl glyceride 0.2g   Solvent Purified water Appropriate amount

Example 11 Prescription 11: In 100 ml of disinfectant               50 ml of isopropanol               Benzalkonium chloride 0.2g   Thickener carboxyvinyl polymer 0.25g   Wetting agent hydroxypropyl cellulose               (Molecular weight 2500) 0.25g   Wetting agent polyethylene glycol               (Molecular weight 20000) 0.25g   pH adjuster diisopropanolamine 0.14g   Emollient triisooctyl glyceride 0.2g   Solvent Purified water Appropriate amount

Example 12 Prescription 12: In 100 ml of disinfectant               83 ml of ethanol               Benzalkonium chloride 0.2g   Thickener Carboxyvinyl Polymer 0.35g   pH adjuster Diisopropanolamine 0.2g   Emollient triisooctyl glyceride 0.2g   Solvent Purified water Appropriate amount

Test example Test methods and results

1. Feeling and spillage of prescription liquid: 5 per group
Named Each tester grabbed 3 ml of the prescribed prescription liquid on his palm and rubbed it in his hands until it dried. At that time, the hardness and spillability of the prescription liquid were examined. The results are shown in Table 1.

2. Bactericidal power test: The following handprint method was used. 1) Preparation method of large-scale agar plate medium. About 200 ml of sterilized SCDLP agar medium (manufactured by Nippon Pharmaceutical Co., Ltd.) was dispensed into a sterilized plastic container having a diameter of 200 mm and a height of 30 mm and having a lid to prepare.

2) Test bacterial solution. Staphylococcus aureus 209P as a gram-positive bacterium
As a Gram-negative bacterium Escherichia coli K-12 OUT
The 8401 was used. Each of the bacteria was inoculated into the SCDLP medium and cultured at 37 ° C. for 20 hours, and the bacterial solution was used for 10 times with physiological saline.
It was diluted twice to obtain a test bacterial solution.

3) Evaluation of disinfection method and sterilizing power. There were 5 people in one group. Each tester took 1 ml of the test bacterial solution in his palm and spread it over both hands. Next, 3 ml of the prescribed prescription liquid was taken in the palm and rubbed into both hands until dried. Then, one palm was imprinted on a large agar plate medium for 10 seconds. The agar medium was cultured at 30 ° C. for 20 hours, and the number of grown colonies was counted. The bactericidal activity of each formulation was evaluated by the average number of colonies of 5 people. As a control, the test bacterial solution was applied to the palm,
An agar medium was impressed without rubbing the formulation solution and the same operation was performed.

Staphylococcus aureus 209 of each prescription liquid
The results for P and Escherichia coli K-12 OUT 8401 are shown in Table 2.

[0034]

[0035]

[Table 1]

[0036]

As is clear from the data of Tables 1 and 2, the viscous rubbing disinfectant according to the present invention is excellent as a hand and finger rubbing disinfectant.

─────────────────────────────────────────────────── ─── Continuation of the front page (56) References JP-A-62-106012 (JP, A) JP-A-3-271221 (JP, A) JP-A-61-165325 (JP, A) (58) Field (Int.Cl. ⁷ , DB name) A61K 31/045 A61K 47/32

Claims (5)

(57) [Claims] 1. A disinfectant containing 50 to 95% by volume of a lower alcohol, which contains carboxyvinyl polymer as a thickening agent in a ratio of 0.1 to 1 g per 100 ml of the disinfectant, and further an organic substance as a pH adjuster. A viscous-rubbing type germicidal disinfectant for hands, which contains an amine. 2. The viscous rub type finger sterilizing agent according to claim 1, wherein the lower alcohol is ethanol or isopropanol. 3. The viscous rub type disinfectant for fingers according to claim 1, further comprising benzalkonium chloride, chlorhexidine gluconate, alkyldiaminoglycine or povidone iodine. 4. The viscous rub type disinfectant for fingers according to claim 1, wherein the organic amine is diisopropanolamine. 5. The sterilizing type disinfectant for viscous rubbing according to any one of claims 1 to 4, which has a pH of 5 to 8.