JPH04305504A - Viscous microbicide composition - Google Patents

Abstract

PURPOSE:To provide a neutral viscous microbicide composition having a viscosity suitable for use, exhibiting highly durable microbicidal activity after application and giving smooth skin. CONSTITUTION:The objective composition can be produced by compounding (A) 50-95vol.% of ethyl alcohol, (B) 0.1-3.0wt.% (preferably 0.5-1.0wt.%) of a carboxyvinyl polymer having a molecular weight of preferably 1,000,000-4,000,000, especially about 1,000,000, (C) 0.01-2.0wt.% (preferably 0.1-0.5wt.%) of an alkanolamine, e.g. an amine selected from mono, di and triethanolamines and (D) 5-50vol.% of water. The obtained mixture is optionally incorporated with one or more compounds selected from quaternary ammonium salt (e.g. benzalkonium chloride) and a fatty acid ester (e.g. glycerol fatty acid ester and sucrose fatty acid ester) to obtain a viscous microbicide composition useful for the disinfection of fingers and having a pH of preferably 5-8, especially 6-7.

Description

[Detailed description of the invention]

0001

[Industrial Application Field] This invention relates to a viscous (gel-like) alcohol-based disinfectant composition for hand disinfection, and more specifically to a composition that has an appropriate viscosity and maintains disinfectant efficacy after use. The present invention relates to a neutral viscous disinfectant composition that has excellent skin properties and smoothness.

0002

[Prior Art] Hand disinfectants are alcohol-based disinfectants containing 60 to 90% by volume of ethyl alcohol and sterilizers containing 10% by weight of benzalkonium chloride, which have strong bactericidal power and are less irritating to the skin. Sterilization methods using disinfectants or alcohol sprayers are known.

0003

[Problems to be Solved by the Invention] However, among these alcohol-based disinfectants, it is difficult to maintain their disinfecting efficacy due to the evaporation of the alcohol after use.

Furthermore, the above-mentioned sterilizing agents and sterilizing methods have the disadvantage that the skin on the hands does not feel smooth after sterilizing and drying.

The present invention overcomes the drawbacks of alcohol-based disinfectants among conventional hand disinfectants, provides an easy-to-use shape with appropriate viscosity, and makes it easy to apply. To provide a viscous disinfectant composition mainly composed of ethyl alcohol for use in neutral hand disinfection, which suppresses evaporation of alcohol in order to maintain the sustainability of subsequent disinfectant efficacy and also provides excellent skin smoothness. The purpose is to

[0006]

[Means for Solving the Problems] The inventors of the present application have developed a product that has an appropriate viscosity, suppresses evaporation of alcohol in order to maintain the sterilizing effect after use, and leaves the skin smooth. As a result of various studies on viscous disinfectant compositions mainly composed of ethyl alcohol for hand sterilization, which are excellent in neutrality, we have found that a specific polymer compound and an alkaline agent are contained in an ethyl alcohol-water system in a predetermined ratio. The present inventors have found that a composition suitable for the above-mentioned purpose has led to the completion of this invention.

That is, the present invention comprises 50 to 95% by volume of ethyl alcohol (Japanese Pharmacopoeia), 0.1 to 3.0% by weight of carboxyl vinyl polymer, 0.01 to 2.0% by weight of alkanolamine, and 5 to 5% by weight of purified water. 50 capacity%
We propose a neutral viscous disinfectant composition consisting of:

[0008] Here, ethyl alcohol (Japanese Pharmacopoeia)
acts as a disinfectant.

[0009] Carboxyvinyl polymer also functions as a thickener (gelling agent) for ethyl alcohol-water systems,
For example, it is an acidic synthetic polymer carboxylic acid in which a carboxyl group (content: 57.7-63.4%) is bonded to a multi-branched cross-linked polymer main chain, and its molecular weight is approximately 1 million to 63.4%.
Good viscosity was obtained for all molecular weights of about 4,000,000, and among them, the best adhesiveness was obtained for those with a molecular weight of about 1,000,000. In addition, regarding the sustainability of the bactericidal effect after use, the addition of carboxyvinyl polymers of any of the above molecular weights was found to be significantly more effective than simple 75% ethyl alcohol without the addition of a thickener. Furthermore, the feel on the skin after use was the same by adding carboxyvinyl polymer with the above molecular weight, but other thickeners such as xanthan gum, hydroxypropyl methylcellulose, and polyvinyl Although pyrrolidone and polyvinyl alcohol were added in the same manner, the viscosity, durability of bactericidal efficacy after use, and feel to the skin were not fully satisfactory.

[0010] The amount of carboxyvinyl polymer to be blended is 0.1 to 3.0% by weight, preferably 0.0% per 100ml of the core composition, from the viewpoint of system stability, usability, and smoothness of the skin after use. It is selected in the range of .5 to 1.0% by weight.

On the other hand, alkanolamine is used as a neutralizing agent for carboxyvinyl polymer, and when this neutralizing agent is used, it can be neutralized while maintaining an appropriate viscosity.

[0012] As the alkanolamine that can be used here, one selected from monoethanolamine, diethanolamine, triethanolamine, etc. can be used.

[0013] It should be noted that p of the viscous fungicide composition of the present invention
The H range is preferably 5 to 8 from the viewpoint of sterilizing power, skin irritation, feel, and viscosity, and particularly preferably pH 6 to 7.
Therefore, the amount of alkanolamine to be blended is 0.01 to 2.0% by weight, preferably 0.1 to 0.5% by weight, based on the amount of carboxyvinyl polymer and the set pH value in 100ml of the composition. selected within the range. In addition, sodium hydroxide, sodium carbonate,
When neutralizing with other alkaline agents such as sodium silicate and aqueous ammonia, appropriate viscosity cannot be obtained and the objective cannot be achieved.

[0014] In addition, other optional ingredients may be added to the viscous bactericidal composition of the present invention to the extent that the bactericidal power, skin irritation, viscosity, and separation stability of the composition are not impaired. For example, quaternary ammonium salts such as benzalkonium chloride, fatty acid esters such as glycerin fatty acid ester, sucrose fatty acid ester, etc. can be used as bactericidal power enhancers, and glycerin and propylene glycol can be used as agents to improve skin protection. It can be added as a feel enhancer. Other fragrances, pigments, etc. can be added.

Furthermore, if the viscous disinfectant composition of the present invention is used with a dedicated dispenser, its practicality can be further improved.

[0016]

[Function] According to the present invention, a carboxyvinyl polymer is used as a thickener (gelling agent) for an ethyl alcohol-water system, and an alkanolamine is used as a neutralizing agent for the carboxyvinyl polymer. A viscous fungicidal composition is obtained.

When this neutral viscous disinfectant composition is used, after a part of the ethyl alcohol has evaporated, the alkanolamine salt of carboxyvinyl polymer, which is a thickener (gelling agent) component, is It is presumed that since a film is formed on the skin, further evaporation of ethyl alcohol is suppressed, thereby sustaining the bactericidal effect and at the same time providing a smooth feel to the skin.

[0018]

EXAMPLES Next, the present invention will be explained in more detail with reference to Examples, but the present invention is not limited to these Examples. The properties of the composition were evaluated as follows. (1) Viscosity ◎: Determined to be a very good gel-like material ○: Determined to be a good gel-like material △: Determined to be viscous but not sufficient ×:
Absolutely no consistency

(2) Appearance Transparency was visually observed. (3) Sustainability of bactericidal efficacy ◎: Significantly observed ○: Observed △: Slightly observed ×: Not observed at all Here, the method for determining bactericidal efficacy is that after sterilization After a certain period of time had elapsed, evaluation was made using food stamps [manufactured by Nissui Pharmaceutical Co., Ltd.]. In addition, food stamps for general viable bacteria, coliform bacteria, and staphylococcus were used, and the method of use thereof was in accordance with the prescribed method.

(4) Smoothness of skin after use ◎: Very smooth feel ○: Smooth feel △: Slightly smooth skin ×: Smooth Something you can't feel at all

[
Examples 1 to 5 In order to investigate thickeners (gelling agents) for ethyl alcohol, disinfectant compositions shown in Table 1 were prepared, and their properties (viscosity, appearance) and disinfectant efficacy were evaluated. Persistence and skin smoothness after use were evaluated. As is clear from this table, the sterilizing composition of the present invention had very good viscosity and exhibited excellent performance in terms of sustainability of sterilizing effect and smoothness of the skin after use.

[0022]

[Table 1]

Example 6 Carboxyvinyl polymer (molecular weight approximately 1 million)
In order to investigate alkaline agents for neutralizing
was evaluated. As is clear from this table, the disinfectant composition of this invention had good viscosity.

[0024]

[Table 2]

[0025]

[Effects of the Invention] In summary, the viscous disinfectant composition for hands and fingers according to the present invention has an appropriate viscosity that is easy to use, has an excellent long-lasting disinfectant effect after use, and is effective against the skin of hands. It is a viscous disinfectant composition of high practical value that is easy to lick. Furthermore, by using a dedicated dispenser, its practical value is further improved.

Claims (3)

[Claims] Claim 1: 50 to 95% by volume of ethyl alcohol;
Carboxyvinyl polymer 0.1 to 3.0% by weight
, 0.01 to 2.0% by weight of alkanolamine, and 5 to 50% by volume of water. 2. The viscous disinfectant composition according to claim 1, wherein the carboxyvinyl polymer has a molecular weight of 1 million to 4 million. 3. The viscous fungicide contains at least one selected from quaternary ammonium salts and fatty acid esters.
The viscous fungicide composition according to claim 1, which contains seeds.