JPH01160922A - Germicide composition - Google Patents

Abstract

PURPOSE:To obtain a composition containing polyacrylic acid long-chain alkyl or alkenylamine salt, germicide and alcohols and having prolonged germicidal effect for preventing dandruff, itch, scalp odor, sweat odor, pimple, etc., and maintaining health of skin. CONSTITUTION:A germicide composition for hair, scalp and skin containing (A) 0.5-3wt.% polyacrylic acid long-chain alkyl or alkenyl amine salt (long- chain alkyl group or alkenyl group is 8-22C), (B) 0.05-0.3wt.% germicide and (C) 90-98wt.% alcohols (e.g., >=60wt.% aqueous solution of ethanol). The compound expressed by formula III includes e.g., a pyrithione based compound expressed by formula I (M is Na, Mg or Zn) or formula II or compound expressed by formula III (R1 is alkyl, aryl, etc.; R2 is H, alkyl, halogen, phenyl, etc.). The above-mentioned composition has reduced outflow loss of germicide by sweat, etc., and excellent prolongation and free from being sticky.

Description

DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to a disinfectant composition that is particularly suitable for use on hair, scalp, and skin. The present invention relates to a sterilizing composition which has a low sterilizing effect, has an excellent long-lasting sterilizing effect, is not sticky when applied to the skin, and has a good feel.

[Conventional technology]

Disinfectants are widely used for the purpose of preventing dandruff, itching, scalp odor, sweat odor, and acne caused by microorganisms, and for maintaining hygiene by sterilizing and disinfecting the skin surface.
Contained in skin cosmetics.

Conventionally, in order to enhance the effectiveness of such useful bactericidal agents, methods have been proposed, such as methods for increasing the bactericidal effect by solubilizing water-insoluble bactericidal agents in water (Japanese Patent Application Laid-Open No. 57-209211, Japanese Patent Publication No. 46-1).
No. 9072) A method of increasing the bactericidal effect by atomizing a granular bactericide (Japanese Patent Publication No. 61-36725), A method of increasing the bactericidal effect by modifying the crystal form of the bactericide (Japanese Patent Publication No. 58-208206) ) and other various proposals have been made.

However, when applied to the hair, scalp, or skin, conventional disinfectants include not only normal disinfectants but also disinfectants with modified properties such as those mentioned above.

Since the amount of effective disinfectant remaining on the skin surface decreases due to sweating, the amount of effective disinfectant remaining on the skin surface is not satisfactory in terms of sustainability.The present invention was developed in view of the above circumstances. The object of the present invention is to provide a bactericidal m-acid which suppresses the reduction in the amount of bactericide remaining on the skin due to sweating, etc., and improves the sustainability of the bactericidal effect.

[Means and effects for solving the problems] In order to achieve the above object, the disinfectant composition of the present invention is a composition containing a long-chain alkyl or alkenylamine salt of polyacrylic acid, a disinfectant, and an alcohol in combination. be.

In the present invention, a water-insoluble polyacrylic acid long-chain alkylamine salt or a polyacrylic acid long-chain alkenylamine salt is used as a base material component, and the parentheses are a polyacrylic acid long-chain alkylamine salt or a polyacrylic acid long-chain alkenylamine salt. By blending alcohol as a solvent to swell or dissolve the salt and adding a disinfectant to this water-insoluble base material, the disinfectant is prevented from flowing out from the skin together with the base material due to perspiration, and therefore, the disinfectant is effectively sterilized. The effect of the agent lasts for a long time, and it is difficult to become sticky due to moisture absorption, so it feels good when used.

The present invention will be explained in more detail below.

As described above, the disinfectant composition of the present invention contains a long-chain alkyl or alkenylamine salt of polyacrylic acid, a disinfectant, and an alcohol.

Here, polyacrylic acid long chain alkylamine salts or polyacrylic acid long chain alkenylamine salts include crosslinked ones, and specifically include acrylic acid, methacrylic acid, chloroacrylic acid, cyanoacrylic acid, maleic anhydride. Polyacrylic acids such as copolymerized monomers of one or more carboxylic acids such as, or those made by reacting the above monomers with an alkenyl ether of a polyhydric alcohol containing at least 4 carbon atoms and 3 hydroxyl groups. A polyacrylic acid long-chain alkyl or alkenylamine salt or a cross-linked polyacrylic acid long-chain alkyl or alkenylamine salt obtained by completely or partially neutralizing cross-linked polyacrylic acid with a long-chain alkylamine or long-chain alkenylamine is preferably used. It is possible. In this case, the long-chain alkylamine or long-chain alkenylamine used to neutralize polyacrylic acid or crosslinked polyacrylic acid has 8 to 2 carbon atoms.
It is particularly preferred to use branched alkylamines such as di(2-ethylhexyl)amine.

In addition, one type of polyacrylic acid long-chain alkyl or alkenylamine salt may be used alone, or two or more types may be used in combination. In addition, the blending amount is 0.05 to 1 of the total composition.
It is preferably 0% by weight, especially 0.5 to 3% by weight; if it is less than 0.05%, the effect of the present invention may not be sufficiently obtained, and if it exceeds 10%, the skin becomes sticky after application. Sometimes.

Furthermore, in the present invention, polyacrylic acid or cross-linked polyacrylic acid which has been neutralized with a long-chain alkyl or alkenylamine may be blended into the composition, but polyacrylic acid or cross-linked polyacrylic acid The polyacrylic acid and the long-chain alkyl or alkenylamine may be separately blended into a composition and neutralized in the composition to produce the polyacrylic acid long-chain alkyl or alkenylamine salt.

In addition, the type of fungicide is not particularly limited, but pyrithione compounds represented by the following - Shipin (1) or (II), 1-hydroxy-2-pyridone represented by the following - Shipin (III), 3,4.4'-trichlorocarbanilide, 2,
4.4'-Trichloro-2'-hydroxydiphenyl ether and salts thereof, odd-numbered fatty acid glycerides represented by Shipman (IV) below, or derivatives thereof can be particularly preferably used.

(In the formula, 1M represents N a HM g or Zn, and n is M
is the number corresponding to the valence of . ) [wherein R1 is an alkyl group having 1 to 17 carbon atoms, an alkenyl group having 2 to 17 carbon atoms, 5 to
cycloalkyl group having 8 carbon atoms, bicycloalkyl group having 7 to 9 carbon atoms, alkyl group having 1 to 9 carbon atoms;
cycloalkyl-alkyl group having 4 carbon atoms (
However, cycloalkyl residues may be substituted with alkyl groups having 1 to 4 carbon atoms), aryl groups, aralkyl groups in which alkyl has 1 to 4 carbon atoms, and alkenyl groups having 2 to 4 carbon atoms. arylalkenyl radicals having 1 to 4 carbon atoms, aryloxyalkyl or arylmercaptoalkyl radicals in which alkyl each has 1 to 4 carbon atoms, benzhydryl radicals, alkyl radicals having 1 to 4 carbon atoms
a phenylsulfonylalkyl group having 4 carbon atoms;
Furyl or alkenyl represents a furylalkenyl group having 2 to 4 carbon atoms, and the above-mentioned aryl residues are alkyl groups having 1 to 4 carbon atoms, alkoxy groups having 1 to 4 carbon atoms, Each may be substituted with a nitro group, a cyano group, or a halogen. R2
represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, an alkenyl or alkynyl group each having 2 to 4 carbon atoms, a halogen, a phenyl group, or a benzyl group. ] [In the formula, Xl, X2. One or more of X is a saturated or unsaturated odd-numbered fatty acid residue having 11 to 21 carbon atoms constituting a carbon chain, and the rest are hydroxyl groups or RCo・0 groups (R is a group having 1 to 21 carbon atoms) 21 alkyl or alkenyl group). ] Note that one type of fungicide may be used alone, or two or more types may be used in combination. Furthermore, the blending amount is 0.0% of the total composition.
It is preferably 0.01 to 0.5% by weight, particularly 0.05 to 0.3% by weight.

Furthermore, alcohols are added to the disinfectant composition of the present invention for the purpose of swelling or dissolving the polyacrylic long-chain alkyl or alkenylamine. In this case, the alcohols include monohydric alcohols such as methanol and ethanol,
One or more polyhydric alcohols such as glycerin, diethylene glycol, and propylene glycol can be used, but it is particularly preferred to use ethanol. The amount of alcohol to be blended is variously selected depending on the type of alcohol, but it is usually 80 to 99% by weight of the entire composition, especially 9% by weight of the entire composition.
The content is preferably 0 to 98% by weight. Note that alcohols can be blended as an aqueous solution, but for example, when using ethanol, the concentration of the ethanol aqueous solution is 6.
It is desirable that the content be 0% by weight or more; if it is less than 60% by weight, it may become impossible to sufficiently swell and dissolve the long-chain alkyl or alkenylamine salt of polyacrylic acid.

The disinfectant composition of the present invention can be prepared as a cosmetic for hair, scalp, skin, etc. In this case, in addition to the above ingredients, the composition may contain oil, a surfactant, a humectant, and an ultraviolet absorber. , antioxidants, amino acids, preservatives, fragrances, anti-inflammatory agents,
Purpose of use of other ingredients such as crude drugs, vitamins, etc.
They can be blended as appropriate depending on the dosage form, etc., and thereby any product can be prepared.

〔Effect of the invention〕

As explained above, the disinfectant composition of the present invention suppresses the outflow of the disinfectant from the skin due to perspiration, etc., and has excellent sustainability of the disinfectant effect.

When applied to the skin, it does not become sticky and has a good feeling of use.

EXAMPLES Next, the present invention will be specifically explained with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples.

[Example, comparative example]

Examples 1 to 6 and Comparative Example 1 with the compositions shown in Tables 1 and 2 above
~5 disinfectant compositions were prepared, and the anti-dandruff effect and feel when applied for Examples 1 to 3, Comparative Examples 1 and 2, and the feel when applied for Examples 4 to 6 and Comparative Examples 3 to 5 were prepared by the following method. evaluated the scalp odor prevention effect and the feel when applied. The results are also listed in Tables 1 and 2.

A panel of 100 men who exercise every day and sweat a lot were asked to wash their hair for two weeks using a shampoo that did not contain any anti-dandruff agents or bactericides, and dandruff stopped on the fourth day after they stopped washing their hair. The degree of dandruff was evaluated according to the following criteria, and 20 panelists (evaluation standard 4 or higher) who had a lot of dandruff washed their hair with the same shampoo as above for one week, and then applied the composition of Example 2 or Comparative Example to their hair. .

5g of the product was applied to the scalp and the degree of dandruff was evaluated 4 days later without washing the hair according to the following criteria. In addition, the evaluation results of the dandruff prevention effect in each table are the average values of the evaluation values of 20 panelists. The lower this value is, the higher the dandruff prevention effect is.

Evaluation criteria 5...There is a lot of dandruff.

4...I have a lot of dandruff.

3...I have some dandruff. 2...There is some dandruff.

1... There is almost no dandruff.

O... No dandruff at all.

A panel of 20 men who exercise every day and have many opportunities to sweat.
After washing the hair with a shampoo containing no bactericide, 5g of the composition of the example or comparative example was applied to the hair and scalp, and after 4 days without washing the hair, the scalp odor was evaluated according to the following criteria. In addition, the evaluation results of the scalp odor prevention effect in each table are the average values of the evaluation values of 20 panelists.

The lower this value is, the higher the scalp odor prevention effect is.

Details JlE exclusive 3...Very strong scalp odor is observed.

2...Strong scalp odor is observed.

1... Slight scalp odor is observed.

0: Not much scalp odor is observed.

1. 2 grams of the compositions of Examples and Comparative Examples were applied to the skin on the inside of the left forearm after washing with soap, and after 1 hour, the feel was evaluated according to the following criteria.

1 plate Gokei O...Almost not sticky.

O...It's not very sticky.

Δ...Slightly sticky.

×...It's sticky.

XX...It's quite sticky.

From the results in Tables 1 and 2, it was confirmed that the disinfectant composition of the present invention has excellent long-lasting disinfectant effects such as preventing dandruff and scalp odor, and also has a good feel when applied. It will be done. On the other hand, the bactericidal composition of the comparative example had a low persistence of bactericidal effect and was very sticky and undesirable to the touch.

In addition, a panel of 20 people (15 men and 5 women) with a lot of acne washed their faces with soap that did not contain disinfectants in the morning and at night. 1 g of the composition of Comparative Example 3 was applied to the face of 4 people.
When the test was carried out for 0 days, the side of the face to which the composition of Example 4 was applied had clearly less acne than the face to which the composition of Comparative Example 3 was applied, indicating that the disinfectant of the present invention is effective in preventing acne. was also found to be effective.

Applicant: Laion Co., Ltd. Agent: Patent Attorney Takashi Kojima

Claims (1)

[Scope of Claims] 1. A disinfectant composition comprising a long-chain alkyl or alkenylamine salt of polyacrylic acid, a disinfectant, and an alcohol. 2. The disinfectant composition according to claim 1, wherein the long-chain alkyl or alkenylamine salt of polyacrylic acid is of a crosslinked type. 3. The long chain alkyl group or alkenyl group of the polyacrylic acid long chain alkyl or alkenylamine salt has 8 to 22 carbon atoms.
The disinfectant composition according to claim 1 or 2, which is a disinfectant composition according to claim 1 or 2. 4. The fungicide composition according to claim 3, wherein the long-chain alkyl group is of a branched type. 5. The fungicide is a pyrithione compound represented by the following general formula [I] and [II], 1 represented by the following general formula [III]
-Hydroxy-2-pyridone, 3,4,4'-trichlorocarbanilide, 2,4,4'-trichloro-2'-hydroxydiphenyl ether and salts thereof, and odd fatty acids represented by the following general formula [IV] The disinfectant composition according to any one of claims 1 to 4, which is selected from glycerides and derivatives thereof. ▲There are mathematical formulas, chemical formulas, tables, etc.▼...[I] (In the formula, M represents Na, Mg, or Zn, and n is a number corresponding to the valence of M.) ▲There are mathematical formulas, chemical formulas, tables, etc. Yes▼... [II] ▲There are mathematical formulas, chemical formulas, tables, etc.▼...[III] [In the formula, R_1 is an alkyl group having 1 to 17 carbon atoms, an alkenyl group having 2 to 17 carbon atoms, 5
cycloalkyl group with ~8 carbon atoms, bicycloalkyl group with 7 to 9 carbon atoms, alkyl is 1
Cycloalkyl-alkyl group having ~4 carbon atoms (however, the cycloalkyl residue may be substituted by an alkyl group having 1 to 4 carbon atoms), aryl group, alkyl group having 1 to 4 carbon atoms an aralkyl group in which the alkenyl has 2 to 4 carbon atoms, an aryloxyalkyl or arylmercaptoalkyl group in which the alkyl each has 1 to 4 carbon atoms, a benzhydryl group, an arylalkenyl group in which the alkyl each has 1 to 4 carbon atoms, ~
a phenylsulfonylalkyl radical with 4 carbon atoms, furyl or alkenyl represents a furylalkenyl radical with 2 to 4 carbon atoms, and the above-mentioned aryl radicals are alkyl radicals with 1 to 4 carbon atoms; Each may be substituted by an alkoxy group having 1 to 4 carbon atoms, a nitro group, a cyano group or a halogen. R
_2 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an alkenyl or alkynyl group each having 2 to 4 carbon atoms, a halogen, a phenyl group, or a benzyl group. 〕▲There are mathematical formulas, chemical formulas, tables, etc.▼…〔
IV] [In the formula, one or more of X_1, X_2, and
It is an O.O group (R is an alkyl or alkenyl group having 1 to 21 carbon atoms). ] 6. Claim 1 in which the alcohol is ethanol
The fungicidal composition according to any one of items 5 to 5. 7. The disinfectant composition according to claim 6, which contains ethanol as an aqueous ethanol solution. 8. The disinfectant composition according to claim 7, wherein the ethanol concentration of the ethanol aqueous solution is 60% by weight or more.