JP3480953B2 - External preparation for skin - Google Patents

Description

Description: BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a novel external preparation for skin and, more particularly, to a method in which peroxides are not produced by oxidation in a product, and after sunburn. The present invention relates to an external preparation for skin which prevents hot flashes, spots, freckles, etc., and has excellent anti-aging and whitening effects. 2. Description of the Related Art Peroxides are harmful to the skin. For example, if peroxides are contained in external skin products such as cosmetics, the use of the peroxides will cause rash and itching of the skin and black skin It has been reported that it may cause diseases such as inflammation and melasma. In recent years, as one of the causes of skin aging, the adverse effect of active oxygen on living organisms, so-called oxygen stress, has been cited. For this reason, the role of antioxidants in skin external preparations is important not only to prevent the formation of peroxides due to oxidation in products, but also to prevent skin aging due to oxygen stress. ing. Conventionally, typical examples of such antioxidants include vitamin E, 2,4-di-tert-butyl-p-cresol, tert-butylhydroxyanisole, and gallic acid ester. It had been. [0004] However, the effect of external preparations for skin is not yet sufficient depending on the combination of conventionally used antioxidants, and even if these substances are used in large amounts. However, there was a problem that it was difficult to obtain a sufficient effect due to restrictions on the composition, and that it was not preferable in terms of stability, and it was not always satisfactory.
Accordingly, there has been a demand for a safe external preparation for the skin which does not generate peroxide due to oxidation and is stable over time. [0005] Under such circumstances, the present inventors have conducted intensive studies and as a result, the following compounds (A) have been added to specific compounds of component (A) described below: , A plant extract) can be used to effectively suppress peroxide formation, prevent hot flashes after sunburn, spots and freckles, and have excellent anti-aging and whitening effects. The present inventors have found that a skin external preparation can be obtained, and have completed the present invention. Namely, the present invention comprises the following components (A) and (B) (A) keratin hydrolysates, vitamins B _2, vitamin D compounds, isopropyl methyl phenol, quercetin, quercitrin, rutin, liquiritin, Whitening characterized by containing one or more kinds selected from gallic acid, gallic acid derivatives and catechin; and (B) one or more kinds of plant extracts selected from Maikaika, Mokka and Ichinin. And a skin external preparation for preventing aging. In the component (A) of the present invention, as the keratin hydrolyzate, for example, one obtained by hydrolyzing wool, feather, hair, skin, etc. with an acid, alkali, enzyme or the like to make it soluble in water is used. be able to. In addition, derivatives such as these reduced products and oxidized products may be used. [0008] Examples of the vitamin B ₂ compounds, riboflavin,
Flavin mononucleotide, flavin adenine dinucleotide and the like can be mentioned, and their derivatives and salts may be used. Examples of the vitamin D include ergocalciferol, cholecalciferol, dihydroxysterol and the like, and derivatives and salts thereof may be used. These vitamin B ₂ , vitamin D, isopropylmethylphenol, quercetin, quercitrin, rutin, liquiritin, gallic acid, gallic acid derivatives, catechin and catechin derivatives are usually commercially available products or plants. Extracted and purified products may be used. Among these (A) components, keratin hydrolysates, rutin and riboflavin butyrate are particularly preferred. These components (A) can be used singly or in combination of two or more. In order to obtain a sufficient effect, these components should be contained in a total content of 0.0001-5.
0% by weight (hereinafter simply indicated as "%"), particularly 0.001%
It is preferable to mix it to 3.0%. The method for preparing the plant extract of the component (B) is not particularly limited. For example, the plant extract is extracted using various suitable solvents at room temperature to under heating. Examples of the extraction solvent include water; lower monohydric alcohols such as methyl alcohol and ethyl alcohol; glycerin, propylene glycol,
Liquid polyhydric alcohols such as 3-butylene glycol; lower alkyl esters such as ethyl acetate; hydrocarbons such as benzene and hexene; and one or more kinds of ethers such as diethyl ether can be used. In particular, one or a mixture of two or more of water, ethyl alcohol, glycerin, and 1,3-butylene glycol is preferable. As the extraction conditions, a solvent is used at a volume ratio of 1 to 1000 times, particularly 5 to 100 times, 4 ° C or more, particularly 15 to
It is preferably carried out at a temperature of 30 ° C. for 1 hour or more, particularly 1 to 3 days. The plant extract obtained under the above-mentioned conditions may be used as it is as an extracted solution, but may be further subjected to a treatment such as concentration and filtration if necessary. These can be used alone or in combination of two or more. The amount of the component (B) is preferably 0.0001 to 10.0% in terms of dry solid content, and more preferably 0.01 to 10.0%.
A range of 1 to 5% is preferred. If the content is less than 0.0001%, the effect is not sufficiently exhibited, and if it exceeds 10.0%, no further increase in the effect is observed. Further, the external preparation for skin of the present invention includes, in addition to the essential components described above, an aqueous component, a powder, a surfactant, an oil agent, and a moisturizing agent, which are commonly used in external preparations for skin, as long as the effects of the present invention are not impaired. Agents, alcohols, pH adjusters, preservatives, pigments,
Other antioxidants, ultraviolet absorbers, thickeners, fragrances, cosmetic ingredients, and the like can be appropriately added as necessary. The external preparation for skin of the present invention can be produced according to a conventional method, and includes a milky lotion, a cream, a lotion, a serum, a cleansing, a pack, a cleansing agent, a foundation, and the like.
In addition, it can be applied as a pharmaceutical, quasi-drug, or cosmetic external preparation for skin in the form of dispersion, granules, ointments and the like. EXAMPLES Next, the present invention will be further described with reference to examples, but the present invention is not limited to these examples. Test Examples In order to confirm the effects of the present invention, a stability test against autoxidation was conducted using Samples 1 to 8 shown in Table 1. That is, the temperature of the oil bath was set to 97.8 ° C., and the air flow was set to 2.
It was set to 3 ml / sec, and the peroxide value (POV) of each sample was measured after 5.5 hours. Table 1 shows the results. In addition, the data in the table was represented by the average value of the measurement results obtained by performing the test three times. [Table 1] As is evident from the results in Table 1, in the case where the extract of squid and the keratin hydrolyzate, riboflavin butyrate or rutin were used in combination, the generation of peroxide was more effective than in the case where each was used alone. And a remarkable antioxidant effect was observed. Example 1 An emulsion having the composition shown in Table 2 was prepared and evaluated for its whitening effect and antiaging effect. Table 3 shows the results. (Preparation method) A Heat mixing (6) to (10) and (14)
Keep at ° C. B. Heat-mix (1)-(5), (11) and (12) and maintain at 70 ° C. CB was added to A and mixed, and (13) was added to emulsify uniformly, and cooled to 30 ° C. to obtain an emulsion. (Usage effect test) Female 15 between 23 and 44 years old
Using the name as a panel, daily, morning and night twice, after washing the face, apply an appropriate amount of the emulsion of each of the present invention products 1 and 2 and comparative products 1 to 4 to the face over a period of 12 weeks. The evaluation was based on the following criteria. Whitening effect Effective: Spots and freckles became less noticeable. Somewhat effective: spots, freckles are less noticeable. Ineffective: No change. Anti-aging effect: Effective: Skin abrasion and gloss are improved. Slightly effective: Skin abrasion, gloss slightly improved. Ineffective: No change. [Table 2] [Table 3] As is clear from the results shown in Table 3, the products 1 and 2 of the present invention in which the extract of Maikai and rutin or isopropyl gallate are combined are comparative products 1 to 3 which are each independently blended, and do not contain these. Compared to Comparative Example 4, it had a remarkable whitening effect and an anti-aging effect. Example 2 Lotion: (Formulation) (%) (1) Glycerin 5.0 (2) 1,3-butylene glycol 6.5 (3) Polyoxyethylene sorbitan monolaurate (20E) ..O.) 1.2 (4) Ethyl alcohol 8.0 (5) Assembly extract ^{* 3} (as dry solids) 0.01 (6) Mocca extract ^{* 4} 2.0 (7) Ergocalciferol 01 (8) Appropriate amount of preservative (9) Appropriate amount of perfume (10) Residual amount of purified water * 3: Ichimaru Falcos * 4: After reflux extraction with 50 V / V% ethyl alcohol,
Filtered and concentrated under reduced pressure and left in a cool place. About 2% dry solids. (Production method) A. (3), (4), and (7) to (9) are mixed and dissolved. B. (1), (2), (5) to (6) and (10) are mixed and dissolved. C. A and B were mixed and made uniform to obtain a lotion. Example 3 Cream: (Formulation) (%) (1) Beeswax 6.0 (2) Cetanol 5.0 (3) Reduced lanolin 5.0 (4) Squalane 30.0 (5) Glycerin monostearate 4.0 (6) Lipophilic glyceryl monostearate 2.0 (7) Polyoxyethylene sorbitan monolaurate (20EO) 2.0 (8) Iclinin extract ^{* 5} 1.0 (9) Keratin hydrolyzate ^{* 6} 0.2 (10) Preservative 0.3 (11) Fragrance 0.05 (12) Remaining purified water * 5: Add 50V / V% ethyl alcohol and shake occasionally After extraction at room temperature for 3 days, the mixture was filtered and concentrated under reduced pressure. About 6% dry solids. * 6: Seiwa Kasei Co., Ltd. (production method) (1) to (7), (10) and (11) are mixed,
Heat and maintain at 70 ° C. B. (8), (9) and (12) are mixed and heated to 7
Keep at 0 ° C. C. B was added to A, mixed, and cooled to obtain a cream. Example 4 Pack: (Formulation) (%) (1) Polyvinyl alcohol 20.0 (2) Ethanol 20.0 (3) Glycerin 5.0 (4) Kaolin 6.0 (5) Bombyx mori extract 0.1 (6) Isopropyl methyl phenol 0.05 (7) Preservative 0.3 (8) Fragrance 0.1 (9) Residual amount of purified water (Production method) (1), (3) to (6) and (9) are mixed,
Heat to 0 ° C and stir. B. (2), (7) and (8) are mixed. C. B was added to A, mixed, and cooled to obtain a pack. Example 5 Detergent: (Formulation) (%) (1) Stearic acid 10.0 (2) Palmitic acid 8.0 (3) Myristic acid 12.0 (4) Lauric acid 4. 0 (5) Oleyl alcohol 1.5 (6) Purified lanolin 1.0 (7) Fragrance 0.1 (8) Preservative 0.2 (9) Glycerin 18.0 (10) Potassium hydroxide 6.0 (11) ) Mocca extract 0.2 (12) Catechin 0.05 (13) Residual purified water (production method) (9), (10) and (13) are mixed and heated to 70 ° C. B. (1) to (6) and (8) are mixed and heated to 70 ° C. C. B was added to A, and the mixture was kept at 70 ° C. for a while. After the saponification reaction was completed, the mixture was cooled to 50 ° C., and (7), (11) and (12) were added. EFFECT OF THE INVENTION The external preparation for skin of the present invention can be safely used because the generation of peroxide by oxidation is effectively suppressed, and it is stable and safe. In addition, it has the effect of preventing and improving aging phenomena such as loss of “gloss” and “stick” on the skin, and also has an excellent whitening effect, and skin due to hot flashes after sunburn, spots, freckles, sunburn, etc. It is effective in preventing and improving the blackening of.

────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁷ Identification code FI A61K 7/00 A61K 7/00 K W X 35/78 35/78 C (56) References JP 50-135236 (JP, A) JP-A-2-180807 (JP, A) JP-A-62-56411 (JP, A) JP-A-62-122209 (JP, A) JP-A-3-275613 (JP, A) -127714 (JP, A) (58) Field surveyed (Int. Cl. ⁷ , DB name) A61K 7/00 A61K 7/48

Claims (1)

(57) Patent Claims 1. A following components (A) and (B) (A) keratin hydrolysates, vitamins B _2, vitamin D compounds, isopropyl methyl phenol, quercetin, quercitrin Or one or more selected from rutin, liquiritin, gallic acid, gallic acid derivatives and catechin; and (B) one or more plant extracts selected from Maika, mocca and iclinin. An external preparation for skin whitening and anti-aging characterized by the following.