JP3453227B2 - Ultraviolet absorber and external preparation for skin containing the same - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an ultraviolet absorbent and a skin external preparation containing the same, and more particularly to an ultraviolet absorbent containing a plant extract-containing component as a main component and a skin external preparation.

[0002]

2. Description of the Related Art Ultraviolet rays contained in sunlight are dermatologically long wavelength ultraviolet rays (UV-) of 400 nm to 320 nm.
A), 320 nm to 290 nm medium wavelength ultraviolet light (UV-
B) Classified as short wavelength ultraviolet rays (UV-C) of 290 nm or less. Of these, ultraviolet rays having a wavelength of 290 nm or less are absorbed by the ozone layer and do not reach the surface of the earth.

Ultraviolet rays reaching the surface of the earth have various effects on human skin. Of the ultraviolet rays that reach the ground, UV-
B forms erythema and blisters on the skin and promotes melanin formation. On the other hand, UV-A causes browning of the skin, lowers the elasticity of the skin and promotes the generation of wrinkles, resulting in rapid aging. It can also accelerate the onset of the erythema reaction, or enhance this reaction for some patients, and even cause phototoxicity or even a photoallergic reaction. Various ultraviolet absorbers have been developed to protect the skin from such harmful effects of ultraviolet rays.

As a wide variety of UV absorbers obtained by chemical synthesis, for example, dibenzoylmethane derivatives, benzophenone derivatives, urocanic acid, p-aminobenzoic acid, 2
-Ethylhexyl p-dimethylaminobenzoate and the like are used, and these are used for prevention of ultraviolet rays.

[0005]

However, the conventional sunscreen cosmetics containing a UV absorber by chemical synthesis have a problem in safety to the skin in terms of photosensitization property, and the amount thereof is limited. It is the most problematic drug among cosmetic ingredients. On the other hand, those derived from natural products generally have a mild action and are highly safe, and it is possible to add a large amount thereof, but as an ultraviolet absorber, the absorption wavelength is 270 nm.
UV-A and / or UV-B, which mostly absorbs the following short-wavelength UV rays, and whose effect on the skin is most problematic
Very few have been known to absorb ultraviolet rays having a wavelength in the region, and none have exhibited sufficient ultraviolet ray absorption effect.

[0006] Furthermore, most of the UV absorbers derived from nature have a markedly lacking photostability, and in reality, most of the substances are extremely difficult to use as UV absorbers. That is, since the product containing the ultraviolet absorber is less stored in the dark, and moreover, it is used in a scene where it is irradiated with light during use, it is not possible to simply have an ultraviolet absorbing ability. UV absorber is not enough,
Excellent light stability is required. The present invention has been made in view of the problems of the prior art as described above, and the object thereof is excellent safety, a high ultraviolet absorption effect in the UV-A and / or UV-B region, and stable to light. Another object of the present invention is to provide a novel ultraviolet absorber and a skin external preparation containing the same.

[0007]

Means for Solving the Problems The present inventors have conducted extensive studies to achieve the above-mentioned object, and as a result, pepper plants,
In particular, it was found that there is a substance having an excellent ultraviolet absorbing ability in the extract fraction from the rhizome of the pepper genus plant, and the present invention has been completed. That is, the ultraviolet absorbent according to claim 1 of the present invention is characterized by containing yangonin as an active ingredient. The ultraviolet absorbent according to claim 2 of the present invention is characterized in that, in the ultraviolet absorbent according to claim 1, a yangonin-containing fraction of a pepperaceae plant (Piperaceae) is blended.

The ultraviolet absorber according to claim 3 of the present invention comprises:
The ultraviolet absorber according to claim 2, wherein a pepper plant
(Piperaceae) is a plant of the genus Pepper (Piper L.). The ultraviolet absorbent according to claim 4 of the present invention is
In the ultraviolet absorber according to claim 2 or 3, the pepper family plant (Piperaceae) is a hippo ( P. methysticum G. Forest) belonging to the genus Pepper (Piper L.). The ultraviolet absorber according to claim 5 of the present invention is the ultraviolet absorber according to claim 2.
The ultraviolet absorber according to any one of 1 to 4, wherein the Yangonin-containing fraction of a pepperaceae plant (Piperaceae) is an extract fraction from the rhizome of the plant . The external preparation for skin according to claim 6 of the present invention is characterized in that it contains the ultraviolet absorber according to any one of claims 1 to 5.

The structure of the present invention will be described in detail below. The present inventors extensively studied natural substances, particularly extracts thereof mainly from plants from the viewpoint of safety of ultraviolet absorbers, and searched for substances having ultraviolet ray absorbing ability. As a result, UV light was detected at a maximum absorption wavelength of 360 nm in a specific fraction of pepper plants.
-A and UV-B regions were found to have an excellent ultraviolet absorbing ability, the active ingredient was specified, and the ultraviolet absorbing agent and the skin having excellent stability and ultraviolet absorbing ability and excellent light stability were also identified. The external preparation was completed. Here, as a pepperaceous plant (Piperaceae) used in the present invention, a hippopotamus ( P. methysticum ) belonging to the genus Pepper (Piper L.) is used.
G. Forest) and the like, and the rhizome is particularly suitable as the site to be used.

As a method for producing the plant extract used in the present invention, the plant is used as a solvent, for example, lower alcohols such as methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isobutanol or lower alcohols containing water, propylene glycol, 1 It can be obtained by extracting with a polyhydric alcohol such as 3,3-butylene glycol or a water-containing polyhydric alcohol, various organic solvents such as acetone and ethyl acetate, and distilling off the solvent. Then, yangonin represented by the structural formula of the following chemical formula 1 was confirmed as an active ingredient exhibiting the ultraviolet absorbing ability in these plant extracts.

[Chemical 1]

Yangonin is a known substance, but its suitability as an ultraviolet absorber has not been known at all until now, and of course, it has been blended as an ultraviolet absorber in a skin external preparation for the purpose of ultraviolet shielding effect. It has never been used. The present inventors have found that the substance having a high ultraviolet absorption ability that was present in the extract fraction from pepper plants was yangonin, and also found that its photostability was extremely excellent. It has been clarified for the first time that has excellent suitability as an ultraviolet absorber. When this yangonin or a plant extract fraction containing yangonin is blended as an ultraviolet absorber, a skin external preparation having high ultraviolet absorbing ability and excellent safety and photostability can be obtained.

As the yangonin used in the present invention, a pepper plant extract obtained by the above extraction method can be used. In addition, the extract may be purified by using activated carbon, column chromatography or the like so as not to impair the effects of the present invention in order to remove the color and odor and make it easier to use. Such an extracted and purified product can also be used in the ultraviolet absorbent and the external skin preparation of the present invention. Of course, yangonin isolated by further purification may be used. It is also possible to produce Yangonin by synthesis and use it.

The content of the plant extract in the total amount of the external preparation for skin of the present invention is preferably 0.005 to 30% by weight as a dried product. If the blending amount is less than 0.005% by weight, the ultraviolet ray absorbing effect is not sufficiently exerted, and if it is blended in an amount of 30% by weight or more, the cost becomes high, which is not realistic.

In addition to the above-mentioned essential components, the UV-absorptive external preparation for skin of the present invention is generally used in cosmetics, quasi drugs, pharmaceuticals, etc., if necessary, within the range not impairing the effects of the present invention. Various components used, an aqueous component, a moisturizer, a thickener, an antiseptic, an antioxidant, a fragrance, a coloring agent, a drug and the like can be added. For example, solid or liquid paraffin, crystal oil, ceresin, ozokerite, hydrocarbons such as montan wax, silicone oils, olive oil, ground wax,
Vegetable or animal fats and oils such as carnauba wax and lanolin, and fatty acids such as stearic acid, palmitic acid, oleic acid, glycerin monostearate, glycerin monooleate, isopropyl isopropyl myristate, and isopropyl stearate. Or esters thereof, esters of monohydric alcohols or polyhydric alcohols of branched fatty acids, alcohols such as ethyl alcohol, isopropyl alcohol, cetyl alcohol, palmityl alcohol, etc., polyhydric alcohols such as glycol, glycerin, sorbitol or esters thereof. And surfactants such as nonionic surfactants, anionic surfactants, and cationic surfactants.

In addition, the following plant extracts and medicines can be appropriately added to the present invention. For example, capsicum, youtei, aloe, wolfberry, mugwort, mustard, rice, mankeishi, mannen wax, kossai ho, nishida, gentian,
Tanjin, loofah, kyoto, pine, kujin, safflower, barberry, areca, eucalyptus, Kagosou, mokuro, goshitsu, psycho, cha, shinui, wasabi, joteishi, netherlands senchi, gardenia, usabasaicin, garlic, mint, Yokuinin, giraffe, palm, burdock, licorice, hop, chrysanthemum, rakkyo, leek, leek, onion, senega, armchadul, mannoke mushroom, dio, monoammonium glycyrrhetinic acid, glycyrrhetinic acid, glycyrrhizinate, sesame, senkyu, kashi and the like.

Further, the dosage form of the ultraviolet absorbent external preparation for skin of the present invention is arbitrary, and for example, liquid, emulsion, cream,
It is possible to take a dosage form such as a stick.

[0017]

The preferred embodiments of the present invention will be described below.
The present invention is not limited to these. Also,
Unless otherwise specified, the compounding amount is shown in% by weight. Extraction Example 1 Raw rhizome of birch ( P. methysticum G. Forest) 100
g Extraction 400 ml of toluene was added to 100 g of the crushed root product of the hippo, and the temperature was 50 ° C., the time was 1 hour, and the rotational stirring was 100 rpm.
The extraction operation was performed. Pressure filtration The extract obtained as described above was filtered under a pressure of nitrogen of 0.1 kg / cm 2 or less, with filter paper No. Filtered by 2.

Concentration The filtrate obtained above was concentrated under reduced pressure at a temperature of 45 to 60 ° C. and a reduced pressure of 35 to 500 torr. Purification 7.7 g of the concentrate was treated with 10 g of activated carbon to remove impurities. Then, using a chromatographic tube having an inner diameter of 5 cm and a length of 50 cm, separation and purification was performed by silica gel column chromatography. As the developing solvent, ethyl acetate-hexane or chloroform-methanol was used. Pressurized filtration As described above, filter paper No. 1 was used at a pressure of 0.1 kg / cm 2 or less of nitrogen. 2 was used and pressure filtration was performed.

As a result, 3.00 g of an extracted and refined product containing yangonin as a main component was obtained. The main component of the extract having an ultraviolet absorbing effect is ¹ H-NMR, GC-M.
It was found to be yangonin by S, organic trace analysis, ultraviolet absorption spectrum (shown in FIG. 1), and infrared absorption spectrum analysis.

Extraction Example 2 Rhizome 100 of raw birch ( P. methysticum G. Forest)
g Extraction To 100 g of the crushed root product of birch, 400 ml of methanol was added, and the temperature was 50 ° C., the time was 1 hour, and the rotational stirring was 100 rp.
The extraction operation was performed at m. Pressure filtration The extract obtained as described above was filtered under a pressure of nitrogen of 0.1 kg / cm 2 or less, with filter paper No. Filtered by 2.

Concentration The filtrate obtained above was concentrated under reduced pressure at a temperature of 45 to 60 ° C. and a reduced pressure of 35 to 500 torr. Purification 7.7 g of the concentrate was treated with 10 g of activated carbon to remove impurities. Then, using a chromatographic tube having an inner diameter of 5 cm and a length of 50 cm, separation and purification was performed by silica gel column chromatography. As the developing solvent, ethyl acetate-hexane or chloroform-methanol was used. Pressurized filtration As described above, filter paper No. 1 was used at a pressure of 0.1 kg / cm 2 or less of nitrogen. 2 was used and pressure filtration was performed.

As a result, 3.85 g of an extracted and refined product containing yangonin as a main component was obtained. The main component of the extract having an ultraviolet absorbing effect is ¹ H-NMR, GC-M.
S, organic trace analysis, analysis of ultraviolet absorption spectrum, infrared absorption spectrum and the like revealed that it was yangonin as in the case of Extraction Example 1.

Next, the present inventors examined the photostability of yangonin. That is, the concentration of Yangonin is 10p
The solution was dissolved in ethanol so as to have pm, the ethanol solution was filled in a glass sample bottle, and irradiation with xenon lamp light was performed at 50 ° C. for 30 hours (corresponding to about 10 days in summer). Then, the ultraviolet absorption spectrum was measured as described above. As a result, in the ultraviolet absorption spectrum, almost no decrease in absorbance due to irradiation with xenon lamp light was observed, and the basic waveform did not change. From the above, it was suggested that yangonin has excellent photostability and is highly suitable as an ultraviolet absorber.

The following is an example of blending the external preparation for skin according to the present invention. Formulation Example 1 Cream A. Oil phase Stearic acid 10.0% Stearyl alcohol 4.0 Glycerin monostearate 8.0 Vitamin E acetate 0.5 Perfume 0.4 Ethylparaben 0.1 Butylparaben 0.1 Propylparaben 0.1 B. Water phase Birch rhizome extract 0.03 1,3-Butylene glycol 10.0 Propylene glycol 8.0 Glycerin 2.0 Potassium hydroxide 0.4 Purified water Residue

<Manufacturing Method> An aqueous phase B was manufactured by further dissolving each component by using a birch rhizome extract previously dissolved in 1,3-butylene glycol. And oil phase A and water phase B
Were heated to 70 ° C., completely dissolved, phase A was added to phase B, and emulsified with an emulsifier. The emulsion was cooled using a heat exchanger to obtain a cream.

Further, the cream according to the present formulation example was diluted with ethanol so that the concentration of the birch rhizome extract was 0.001%, put into a quartz cell, and measured with a spectrophotometer.
As a result of measuring the absorbance at a wavelength of 00 to 600 nm, 300 to 300 is obtained as in the ultraviolet absorption spectrum of Extraction Example 1 (FIG. 1).
It has a high absorption capacity in the wavelength region near 380 nm,
It was suggested that it is effective in preventing sunburn. Moreover, the cream of this formulation example was also excellent in moisture retention.

All of the following external preparations for skin were highly safe and had excellent ultraviolet absorbing effect, as in Formulation Example 1. It was also an external preparation for skin, which was excellent in moisturizing property. Formulation 2 Cream A. Oil phase Cetanol 4.0% Vaseline 7.0 Isopropyl myristate 8.0 Squalane 12.0 Dimethylpolysiloxane 3.0 Glycerin monostearate 2.2 POE (20) sorbitan monostearate 2.8 Glycyrrhetinic acid stearate 0.02 Ethylparaben 0.1 Butylparaben 0.1 Yangonin 0.1 B.I. Aqueous phase 1,3-butylene glycol 7.0 Phenoxyethanol 0.2 L-Ascorbic acid phosphoric acid ester magnesium salt 3.0 Ascorbic acid phosphoric acid ester magnesium salt 1.0 Purified water Residue

<Manufacturing Method> A cream was obtained according to Formulation Example 1 after it was dissolved in yangonin in the oil phase in advance.

Formulation Example 3 Emulsion A. Oil phase Squalane 5.0% Oleyl oleate 3.0 Vaseline 2.0 Sorbitan sesquioleate 0.8 Polyoxyethylene (20) oleyl ether 1.2 2-Ethylhexyl-p-methoxycinnamate 3.0 Perfume 0.1. 12 B. Water phase Hippo rhizome extract 0.2 Dipropyne glycol 5.0 Ethanol 3.0 Carboxy vinyl polymer 0.17 Sodium hyaluronate 0.1 Potassium hydroxide 0.08 Methylparaben 0.15 Sodium hexamethanephosphate 0.05 Purification Water residue

<Manufacturing Method> The birch rhizome extract was previously dissolved in dipropylene glycol, and then a milky lotion was obtained according to Formulation Example 1.

Formulation Example 4 Cream A. Oil phase Behenyl alcohol 0.5% 12-Human doxystearic acid cholestanol ester 2.0 Squalane 7.0 Jojoba oil 5.0 Self-emulsifying glyceryl monostearate 2.5 Polyoxyethalene (20) sorbitan monostearate 1 .5 2-hydroxy-4-methoxybenzophenone 3.0 ethylparaben 0.2 butylparaben 0.1 perfume 0.1 B.I. Aqueous phase 1,3-butylene glycol 6.0 Hippo rhizome extract 0.05 Glycerin 3.5 Zinc oxide 1.5 Kaolin 0.5 Bentonite 0.3 Sodium hexametaphosphate 0.03 Purified water Residue

<Manufacturing Method> After dissolving the birch rhizome extract in 1,3-butylene glycol, a cream containing powder was obtained by a manufacturing method according to Formulation Example 1.

Formulation Example 5 Essence A. Oil phase Stearic acid 3.0% Cetanol 1.0 Lanolin derivative 3.0 Liquid paraffin 5.0 2-Ethylhexyl stearate 3.0 POE Cetyl alcohol ether 2.0 Glycerin monostearate 2.0 Hippo rhizome extract 10. 0 Preservative Suitable amount Perfume Suitable amount B. Water phase 1,3-butylene glycol 6.0 Triethanolamine 10.0 Purified water Residual

<Manufacturing Method> A birch rhizome extract was dissolved in 1,3-butylene glycol, and this was dissolved in purified water together with triethanolamine to prepare an aqueous phase B. Stearic acid, cetanol, lanolin derivative, liquid paraffin, 2
-Ethylhexyl stearate and glyceryl monostearate were dissolved by heating at 70 to 80 ° C, and then POE cetyl alcohol ether, preservative, and fragrance were sequentially dissolved, and the temperature was adjusted to 70 ° C to produce oil phase A. The oil phase A was added to the above-mentioned aqueous phase B while stirring, emulsification was carried out, the emulsified particles were uniformly prepared with a homomixer, and then deaeration and cooling were carried out to obtain an essence.

Formulation Example 6 Essence A. Ethanol phase Sorbitan monooleate 1.0% Oleyl alcohol 0.5 Vitamin E acetate 0.2 Perfume proper amount Ethanol 10.0 POE sorbitan dilaurate monostearate ester 1.0 Preservative proper amount anti-fading agent proper amount B. Water phase Birch rhizome extract 0.05 Dipropylene glycol 5.0 Polyethylene glycol 400 5.0 Carboxyvinyl polymer 0.3 Sodium alginate 0.3 Potassium hydroxide 0.15 POE sorbitan dilaurate monostearate 1.0 Placenta extract 0.2 Purified water Residual

<Manufacturing Method> After dissolving the carboxyvinyl polymer in purified water, dipropylene glycol, polyethylene glycol 400 and birch rhizome extract were sequentially dissolved to obtain an aqueous phase B. POE sorbitan dilaurate monostearate ester, sorbitan monooleate ester, oleyl alcohol, vitamin E acetate, perfume, preservative and anti-fading agent are sequentially dissolved in ethanol to obtain ethanol phase A, and ethanol phase A is converted to aqueous phase B. And emulsified. Potassium hydroxide was dissolved in a portion of purified water, and this was added, stirred, degassed, and filtered to obtain an essence.

Formulation Example 7 Oil-in-water foundation A. Powder talc 3.0% Titanium dioxide 5.0 Red iron oxide 0.5 Yellow iron oxide 1.4 Black iron oxide 0.1 B. Water phase Bentonite 0.5 Polyoxyethylene sorbitan monostearate 0.9 Triethanolamine 1.0 Propylene glycol 10.0 Hippo rhizome extract 0.1 Purified water 56.4 C.I. Oil phase Stearic acid 2.2 Isohexadecyl alcohol 7.0 Glycerin monostearate 2.0 Liquid lanolin 2.0 Liquid paraffin 8.0 Preservative proper amount Perfume proper amount

<Production Method> Part of the birch rhizome extract was previously dissolved in propylene glycol, and bentonite, which is a thickener for the aqueous phase, was dispersed in the rest of propylene glycol. After adding these to purified water and treating with a homomixer at 70 ° C,
The remaining aqueous phase ingredients were added and stirred thoroughly. The powder portion that had been thoroughly mixed and pulverized was added to this while stirring and subjected to homomixer treatment at 70 ° C. Next, the oil phase heated and dissolved at 70 ° C. to 80 ° C. was gradually added and subjected to a homomixer treatment at 70 ° C. Cool this with stirring, add perfume at 45 ° C,
After cooling to room temperature, finally degassing and filling into a container, an oil-in-water foundation was obtained.

Formulation Example 8 W / O type foundation (cream type) A. Powder sericite 5.36% Kaolin 4.0 Titanium dioxide 9.32 Red iron oxide 0.36 Yellow iron oxide 0.8 Black iron oxide 0.16 B. Oil phase Liquid paraffin 5.0 Decamethylcyclopentasiloxane 12.0 Polyoxyethylene-modified dimethylpolysiloxane 4.0 Purified water 51.9 C.I. Aqueous phase dispersant 0.1 1,3-Butylene glycol 5.0 Hippo rhizome extract 0.08 Purified water 51.9 Preservative proper amount D.I. Other stabilizers 2.0 Fragrance suitable amount

<Manufacturing Method> The birch rhizome extract was previously dissolved in 1,3-butylene glycol, and the aqueous phase was further heated and stirred at 70 ° C., and then the powder portion thoroughly mixed and pulverized was added and treated with a homomixer at 70 ° C. did. A stabilizer dissolved in a part of purified water was added to this and stirred. Further, the oil phase heated to 70 ° C. was added, and the mixture was treated with a homomixer at 70 ° C. This was cooled with stirring, a fragrance was added at 45 ° C., cooled to room temperature, finally deaerated and filled in a container to obtain a W / O emulsion type foundation.

Formulation Example 9 W / O type cream type sunscreen cosmetic A. Aqueous phase Purified water 54.95% 1,3-Butylene glycol 7.0 Titanium dioxide 5.0 Disodium edetate 0.05 Ethanol 2.0 Gecchi root extract 0.5 B.I. Oil phase Oxybenzone 2.0 Octyl paramethoxycinnamate 5.0 Vaseline 5.0 Stearyl alcohol 3.0 Birch rhizome extract 10.0 Stearic acid 3.0 Glyceryl monostearate 3.0 Polyethyl acrylate 1.0 Antioxidant Appropriate amount Preservative Appropriate amount Perfume Appropriate amount

<Production method> The oil phase part and the water phase part are each 70 ° C.
It was heated to and dissolved. Titanium dioxide was sufficiently dispersed in the water phase portion, the oil phase portion was added, and the mixture was emulsified using a homogenizer. The emulsion was cooled using a heat exchanger to obtain a W / O cream type sunscreen cosmetic.

Formulation Example 10 O / W type emulsion type sunscreen cosmetic A. Water phase Purified water 68.3% Dipropylene glycol 6.0 Ethanol 3.0 Hydroxyethyl cellulose 0.3 Hippo rhizome extract 0.005 B.I. Oil phase Octyl paramethoxycinnamate 6.0 Glyceryloctyl diparamethoxycinnamate 2.0 4-tert-Butyl 4′-methoxybenzoylmethane 2.0 Oxybenzone 3.0 Oleyloleate 5.0 Dimethylpolysiloxane 3. 0 Vaseline 0.5 Cetyl alcohol 1.0 Sorbitan sesquioleate ester 0.8 POE (29) oleyl alcohol ether 1.2 Antioxidant proper amount Preservative proper amount Perfume proper amount

<Manufacturing Method> The birch rhizome extract was dissolved in ethanol in advance, and the extract was combined with other aqueous phase components and heated to 70 ° C. to prepare an aqueous phase. Then, the oil phase portion was heated and dissolved at 70 ° C. The oil phase part was added to the water phase part and emulsified using a homogenizer. The emulsion was cooled using a heat exchanger.

Formulation Example 11 W / O type cream type sunscreen cosmetic A. Water phase Purified water 36.5% 1,3-butylene glycol 6.0 Hippo rhizome extract 1.0 B.I. Oil phase Octyl paramethoxycinnamate 5.0 Oxybenzone 3.0 4-tert-butyl 4'-methokidibenzoylmethane 1.0 Hydrophobized titanium dioxide 3.0 Squalane 40.0 Glycerin diisostearate 3.0 Organically modified Montmorillonite 1.5 Preservative Suitable amount Perfume Suitable amount

<Manufacturing Method> The birch rhizome extract was previously dissolved in ethanol, and the oil phase part and the aqueous phase part were each dissolved by heating at 70 ° C. Titanium dioxide was sufficiently dispersed in the oil phase portion, and the water phase portion was added while performing the homogenizer treatment. The emulsion was cooled using a heat exchanger.

Formulation 12 Lotion Purified water 40.0% Dipropylene glycol 5.0 1,3-Butylene glycol 10.0 Polyethylene glycol 400 10.0 Ethyl alcohol 20.0 Polyoxyethylene (60) hydrogenated castor oil 3. 0 Octyl paramethoxycinnamate 1.0 Hippo rhizome extract 5.0 Triethanolamine 5.0 Perfume Suitable amount

<Production Method> Polyoxyethylene (60) hydrogenated castor oil, octyl paramethoxycinnamate and a fragrance were dissolved in ethyl alcohol (alcohol phase). on the other hand,
The Geckitz root extract was dissolved in 1,3-butylene glycol in advance, and purified water and other polyhydric alcohols were further added and sufficiently dissolved (aqueous phase). The alcohol phase was added to the aqueous phase, and the mixture was thoroughly stirred.

Formulation Example 13 O / W type emulsion type sunscreen cosmetic A. Oil phase Liquid paraffin 3.0% Isopropyl myristate 2.0 Oleyl oleate 4.0 Vaseline 2.0 Stearyl alcohol 1.0 Stearic acid 2.0 Glyceryl monostearate 2.0 Vitamin E acetate Suitable amount Preservative Suitable amount Perfume proper amount B. Aqueous phase Purified water 77.8 1,3-Butylene glycol 6.0 Carboxyvinyl polymer 0.2 Triethanolamine Appropriate amount Birch rhizome extract 0.1

<Manufacturing Method> The birch rhizome extract was previously dissolved in 1,3-butylene glycol, and the oil phase part and the aqueous phase part were each dissolved by heating at 70 ° C. The oil phase was added to the aqueous phase, and the mixture was emulsified using a homogenizer. The emulsion was cooled using a heat exchanger.

[0051]

As described above, according to the ultraviolet absorbent and the external skin preparation containing the same according to the present invention, safety and light stability can be improved by adding yangonin or a plant extract containing the same as a main component. It has high properties and can obtain an excellent ultraviolet absorbing effect.

[Brief description of drawings]

FIG. 1 is a birch ( P. methysticum) according to an embodiment of the present invention.
FIG. 3 is an ultraviolet absorption spectrum diagram of a toluene extract of G. Forest) rhizome (Extraction Example 1).

─────────────────────────────────────────────────── ─── Continuation of the front page (72) Kenji Tsujimoto, 1-6-88, Tsurumi, Tsurumi-ku, Osaka-shi, Osaka Prefecture Tsujimoto Chemical Co., Ltd. (56) Reference JP-A-6-336417 (JP, A) (58) ) Fields surveyed (Int.Cl. ⁷ , DB name) A61K ^7/ 00-7/50

Claims (6)

(57) [Claims] 1. An ultraviolet absorber containing yangonin as an active ingredient. 2. The ultraviolet absorber according to claim 1, wherein a yangonin-containing fraction of a pepperaceae plant (Piperaceae) is blended. 3. The ultraviolet absorbent according to claim 2, wherein the pepperaceae plant (Piperaceae) is a genus of pepper (Piper L.).
An ultraviolet absorber characterized by being a plant. 4. The ultraviolet absorber according to claim 2 or 3, wherein the pepperaceae plant (Piperaceae) is a genus (Pepe).
An ultraviolet absorbent characterized by being a hippo (P. methysticum G. Forest) belonging to r. 5. The ultraviolet absorbent according to claim 2, wherein the Yangonin-containing fraction of a pepperaceae plant (Piperaceae) is an extracted fraction from the rhizome of the plant. Absorbent. 6. An external preparation for skin comprising the ultraviolet absorbent according to claim 1 incorporated therein.