JP3443798B2 - Blister bottom material - Google Patents

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a press-through pack packaging (hereinafter referred to as PTP packaging) for medicines such as tablets and capsules and various foods, and a blister bottom material for ampoules of medicines and various foods. The present invention relates to a blister bottom material having a function of blocking light of a wavelength.

[0002]

2. Description of the Related Art For example, a PTP package is made up of a plastic sheet 1 having a large number of recesses 3 (hereinafter sometimes referred to as pockets) as shown in FIG. 1, and one drug 4 such as a capsule tablet is provided in each recess 3. And the entire surface is covered with a lid material 2 made of aluminum foil or an easily openable plastic sheet or paper. The plastic sheet 1 forming the large number of recesses 3 is called a blister bottom material, and a vinyl chloride resin sheet has been conventionally used. However, as the vinyl chloride resin sheet, polypropylene-based sheets and amorphous polyester-based sheets have been recently used from the viewpoint of environmental protection due to problems such as generation of chlorine gas during incineration and problems such as dioxins. By the way, PTP packaging and blister packaging generally require visibility of stored items. From this point, polypropylene-based sheets and amorphous polyester-based sheets are transparent and are often used because they are excellent in visibility. However, some medicines and foods stored in PTP packaging or blister packaging are unstable with respect to light of a specific wavelength, and the blister bottom material is required to have a function of blocking light of a specific wavelength (light blocking property). May be done.

In order to impart the above-mentioned light-shielding property, a method is conceivable in which a polypropylene resin or polyester resin is mixed with a pigment, a dye and an ultraviolet absorber and the mixture is molded into a sheet by a melt extrusion method. However, when the blister bottom material is manufactured by such a method, the polypropylene resin and the polyester resin have the following problems because the dyes and pigments are difficult to disperse. (1) Since polypropylene-based sheets and polyester-based sheets are mainly produced by the T-die extrusion method, when an attempt is made to produce a colorless transparent sheet after producing a colored sheet in which pigments and dyes are mixed, an extruder or T-die is used. When a colorless and transparent sheet is manufactured, residual pigments and dyes are likely to cause contamination problems. Further, it takes time and effort to change lots when manufacturing colored sheets of other types, and is not suitable for manufacturing small lots. (2) In a method of mixing a dye or a pigment in a polypropylene resin or a polyester resin, heating and melting at 150 to 300 ° C., and extruding by T die or inflation to form a sheet, the pigment and the dye are evenly distributed in the resin. Since it is difficult to disperse in, the color unevenness is likely to occur during melt extrusion. In addition, the color selection range is small for colors that are easily dispersed uniformly. (3) When the above-mentioned sheet is manufactured by the above-mentioned method, since the ultraviolet absorbent, pigment, dye, etc. are present on the surface that comes into direct contact with the drug or food, it contacts the drug or food, and the interaction of the drug or food May affect safety. (4) Since the above-mentioned manufacturing method only mixes pigments and dyes into the resin sheet, detailed display of characters, symbols and the like cannot be performed.

[0004]

Therefore, the present inventor has completed the present invention as a result of various studies to solve the above problems, and the present invention avoids the above-mentioned contamination, and at the same time, the pharmaceutical or food product. An object of the present invention is to provide a blister bottom material that does not have the possibility of interaction with the blister bottom material. Another object of the present invention is to provide a blister bottom material capable of displaying detailed characters, symbols and the like without double-sided printing on a lid material such as paper or aluminum foil.

[0005]

The gist of the present invention is a blister bottom material obtained by laminating a plurality of resin layers, which is an ultraviolet light obtained by applying a paint containing a dye by printing between the resin layers. A blister bottom material having a line blocking layer. That is, the present invention uses printing between a plurality of resin layers .
Ri can prevent the occurrence of contamination due to a pigment or dye remaining on the extruder and T in the die because contain any ultraviolet blocking layer formed by coating a coating composition containing a dye, by this, the pharmaceutical and food it was to ensure the avoid of medicines and food safety interactions.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION The present invention will be described in more detail. The blister bottom material according to the present invention is made of polypropylene (P
P), a plurality of resin layers of polyolefins such as polystyrene and cyclic polyolefin and polyesters such as polyethylene terephthalate (PET). These resin layers may be different from each other, for example PP and A
A combination of different resins such as -PET (amorphous polyester) may be used, but it is preferable to use a resin containing a common resin as a main component from the viewpoint of easy disposal such as recycling, disposal and incineration. A polypropylene resin or a polyester resin is preferable for the common resin layer. That is, vinyl chloride was the mainstream of conventional blister bottom materials, but chlorine gas generation during incineration has become a problem, while polypropylene-based resins and polyester-based resins can generate chlorine gas during incineration. Since it is not present, it is preferable from the viewpoint of environmental problems, and polypropylene resin is preferable because it has excellent moisture resistance. Additives may be added to this resin for the purpose of improving moldability.

In the blister bottom material of the present invention, as described above, the ultraviolet blocking layer having the coating material containing the pigment such as the pigment or the dye and / or the ultraviolet absorbing agent applied by printing is present between the resin layers. With such a laminated structure, the blister bottom material of the present invention is less likely to be rubbed off than the case where an ultraviolet blocking layer is provided on one surface of the blister bottom material, and the blister bottom material is wound up. Even when stored in, there is no migration of pigments, dyes and UV absorbers to the opposite side, and the separation from the stored items is certain, and the like. The pigment used in the present invention is not particularly limited, and known pigments and dyes can be appropriately used. Pigments do not elute, and are highly safe in terms of hygiene, and since many dyes have excellent compatibility with resins, they are dispersed uniformly and do not hinder visibility. As a means for forming the ultraviolet blocking layer, an ink containing a dye and / or a dye and an ultraviolet absorber is applied using a printing machine . When applied using printing machine, when applied with a gravure roll, it is uniformly applied,
Further, it is preferable because the amount of coating can be easily adjusted and detailed partial coating can be performed. By enabling such detailed partial coating, it becomes possible to display various information on the bottom material itself in PTP packaging, for example.
In other words, it is possible to perform solid printing on the pocket portion and mainly to protect the contents, and to print the symbols of the chemicals and the usage method in detail on the portion other than the pocket .

The color of the pigment or dye used in the ultraviolet blocking layer in the present invention is preferably red to yellow or white. Red to yellow blocks light in the short wavelength range which is likely to adversely affect the packaged contents. Specifically, it is preferable to block the light of 380 to 560 nm. When the wavelength of the blocking light becomes longer, the red color shifts toward yellow. Therefore, red to yellow here is crimson,
Including red, golden red, orange, yellow, etc. The white pigment or dye in the present invention blocks light having a short wavelength of 380 nm or less which cannot be blocked by the red pigment. By using an ultraviolet absorber in combination or alone, the degree to which the contents can be seen through can be adjusted arbitrarily. The specific coating amount is about 0.5 to 8 g / m ² , and the thickness of the ultraviolet blocking layer is about 0.5 to 30 μm including the adhesive and the extrusion resin.

In the present invention, the dyes usable in the ultraviolet blocking layer include inorganic pigments such as zinc white, titanium oxide pigments, lithophone pigments, zinc sulfide and the like, or azo type, anthraquinone type, heterocyclic type, methine type and perinone type pigments. And the like, and specific examples thereof include dyes such as azo pigments such as lake red C and lake red D. Further, as the ultraviolet absorber, which is generally used in plastic molding, for example, benzophenone-based Seethorp 101 (manufactured by Cypro Kasei), benzotriazole-based Tinuvin P (manufactured by Ciba Geigy), salicylate-based Examples of the bio-soap 90 (manufactured by Kyodo Chemical Co., Ltd.) and cyanoacrylate-based bio-soap 910 (manufactured by Kyodo Chemical Co., Ltd.) The amount of the ultraviolet blocking layer <br/> in key 1 00 0 parts to 8 parts per part by weight, more preferably 5 parts 0.01 parts. In the present invention, in addition to the above-mentioned dye or ultraviolet absorber, a compounding agent such as a filler or a lubricant which is usually compounded in plastic inks or adhesives may be added to the ultraviolet blocking layer.

In the case of a two-layer PTP bottom material composed of a polypropylene resin layer as an example in the present invention,
For example, a polypropylene sheet having a thickness of 10 to 200 μ
An ultraviolet blocking layer containing a dye or a dye and an ultraviolet absorber is present on the surface of (A), and 50 to 50
400 μm polypropylene-based sheets (B) are laminated to give a total thickness of 150 to 500 μm. The thickness of the polypropylene sheet (A) is about 10 to 200 μm, and 1
When the thickness is less than 0 μm, the interaction with the drug cannot be sufficiently prevented, and even when the thickness is 200 μm or more, the action is not different. The polypropylene-based sheet (B) may be a coextruded sheet having a multilayer structure of two or more layers depending on the case.

FIG. 1 is a perspective view of a conventional PTP package, and FIG. 2 is a sectional view of a PTP package using a blister potom material according to the present invention. Then, FIG. 3 shows an example of a laminated structure of a blister potom material according to the present invention. In FIG. 1, a large number of recesses (pockets) 3 are provided in a transparent polypropylene sheet 1, capsule-shaped tablets 4 are housed in the pockets 3, and a lid material 2 is attached thereon. In the PTP packaging of the blister potom material according to the present invention, as shown in FIG. 2, the polypropylene sheet 1 has the ultraviolet ray blocking layer 5 interposed between the polypropylene sheet A and the polypropylene sheet B. FIG. 3 shows an example of a laminated structure of a blister potom material according to the present invention, in which a printing layer 6 and an adhesive layer 7 are provided on a polypropylene sheet A, and a polypropylene sheet B is laminated via an adhesive layer. To do. Next, the present invention will be specifically described with reference to examples.

[0012]

Examples and Comparative Examples Example 1 (1) Melting point 162 ° C., yield point strength 3.0 kgf / mm ²
A non-stretched polypropylene sheet of 50 μm was subjected to corona discharge treatment on one side, and then about 1.1 g / m ² of an ink containing a polyurethane-vinyl chloride / vinyl acetate orange pigment was gravure-printed, and then a white pigment of the same type. Ink containing 0.8 ~
Gravure printing was performed by superimposing 5.0 g / m ² . (2) A polyester-based polyurethane adhesive of about 3.0 g / m ² was applied to the printed surface of this white ink, and a 250 μm polypropylene sheet (25 μm melting point 162 ° C. polypropylene and 200 μm melting point 162 ° C. polypropylene was aromatic. 25 μm with a mixture of petroleum hydrocarbon resins
And a corona discharge treated surface of a 2 layer 3 layer coextrusion sheet with polypropylene having a melting point of 162 ° C.). (3) respectively, for sample B coating amount of the white ink is about 4.9 g / m ² of coating amount of the white ink is about 3.3 g / m ² Sample A (1) of the sample (1) The light transmittance of each wavelength in FIGS. 4 and 5 was obtained. Also, instead of the orange ink of (1), about 1.5 g of red ink
/ M ² for sample C printed with white ink 1.5 / m ² after printing the light transmittance of Figure 6 were obtained. (4) Also, with respect to A, B, and C, it was possible to see the sample through the naked eye. (5) Also, this sample is, for example, FBM manufactured by CKD Co., Ltd.
-It was possible to mold into a PTP pocket with a -2PTP blister packaging machine or the like. (6) The 50 μm polypropylene film and 250 μm polypropylene sheet of this sample had an interlaminar peel strength of 40 at a speed of 300 mm / min and a peel angle of 180 °.
It had a strength of 0 gf / 25 mm or more, and peeling did not occur even when molded by a PTP packaging machine.

[0013]

As described above, the blister bottom material having the ultraviolet ray blocking layer formed by applying the coating material containing the dye by printing between the two resin layers of the present invention, In the PTP packaging using, the medicines and foods stored do not come into direct contact with the UV absorbers, so there is no concern about the safety of the medicines due to the interaction, there is no color unevenness, and the existence of the UV-blocking layer allows for long-term use of the medicines. Can be saved. In addition, it is possible to print detailed information about stored items without double-sided printing on a lid material such as paper or aluminum foil.

[Brief description of drawings]

FIG. 1 is a perspective view of a PTP.

FIG. 2 PT using the blister bottom material of the present invention
Cross section of P package

FIG. 3 shows a laminated structure of an example of a blister bottom material according to the present invention.

FIG. 4 is a light absorption curve of Sample A in Example 1.

5 is a light absorption curve of Sample B in Example 1. FIG.

FIG. 6 is a light absorption curve of Sample C in Example 1.

[Explanation of symbols]

DESCRIPTION OF SYMBOLS 1 Polypropylene sheet 2 Lid material 3 Recesses 4 Capsule tablet 5 UV blocking layer 6 Printing layer 7 Adhesive layer

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Claims (5)

(57) [Claims] 1. A blister bottom material formed by laminating a plurality of resin layers, wherein the resin layers are coated with a dye by printing.
A blister bottom material having an ultraviolet blocking layer formed by applying a material. 2. The blister bottom material according to claim 1, wherein the plurality of resin layers are made of a resin containing a common resin as a main component. 3. The blister bottom material according to claim 2, wherein the common resin is polypropylene. 4. Any of the claims 1 to 3, wherein the ultraviolet blocking layer is formed by further applying a coating material containing the ultraviolet absorbent in the resin layer
The blister bottom material described in that section . 5. A blister bottom material according to any one of claims 1-4, wherein said dye is a red to yellow and / or white.