JP4080638B2 - Blister bottom material having a colored layer - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to press-through pack packaging (hereinafter referred to as PTP packaging) for pharmaceuticals such as tablets and capsules and various foods (hereinafter referred to as PTP packaging) and blister bottom materials for pharmaceutical ampoules and various foods, etc. The present invention relates to a blister bottom material capable of giving a detailed description.
[0002]
[Prior art]
For example, the PTP packaging is made of a plastic sheet 1 having a large number of recesses 3 (hereinafter sometimes referred to as pockets) as shown in FIG. 1, and stores a drug 4 such as a capsule tablet in each recess 3, The entire surface is covered with a lid 2 made of aluminum foil, an easily openable plastic sheet or paper. And the plastic sheet 1 which forms this many recessed part 3 is called a blister bottom material, and the vinyl chloride resin sheet was used conventionally. However, as a vinyl chloride resin sheet, a polypropylene sheet or an amorphous polyester sheet has recently been used from the viewpoint of environmental protection due to problems such as generation of chlorine gas during incineration and dioxin.
By the way, PTP packaging and blister packaging (hereinafter collectively referred to as blister packaging) generally require visibility of stored items. From this point, polypropylene-based sheets and amorphous polyester-based sheets are frequently used because of their high transparency and excellent visibility. However, in medicines and foods stored in blister packs, depending on their medicinal properties and usage, coloring, symbols and explanations that make them stand out from those of similar packaging forms can be read from the surface (bottom material side). May require printing. Therefore, it may be required that the blister package is colored or printed.
[0003]
For example, when coloring a blister bottom material, the method of mixing a pigment and dye with resin and shape | molding this to a sheet | seat by the melt extrusion method can be considered. However, when the blister bottom material is produced by such a method, the following problems arise because the polypropylene resin and the polyester resin are difficult to disperse dyes and pigments.
(1) Since polypropylene-based sheets and polyester-based sheets are mainly manufactured by the T-die extrusion method, when an attempt is made to manufacture a colorless transparent sheet after manufacturing a colored sheet mixed with pigments and dyes, an extruder or T-die is used. The pigments and dyes remaining inside are prone to contamination problems when producing colorless and transparent sheets. Furthermore, when manufacturing colored sheets of other varieties, it takes time and labor to change the lot, and it is not suitable for manufacturing a small lot.
(2) In a method in which a dye or pigment is mixed in a polypropylene resin or polyester resin, heated and melted to 150 to 300 ° C., extruded by T-die or inflation, and the sheet is formed into a film, the pigment and dye are uniform in the resin. Therefore, color unevenness is likely to occur during melt extrusion. Moreover, the color selection range is narrow for colors that are easily dispersed uniformly.
(3) When the above sheet is manufactured by the above method, since there are pigments and dyes on the surface that comes into direct contact with the drug and food, the sheet contacts with the drug and food, and the interaction affects the safety of the drug and food. There is a risk of giving.
(4) Since the above production method only mixes pigments and dyes into the resin sheet, detailed display of characters, symbols, etc. could not be made.
[0004]
In addition, when printing so that symbols and the like can be read from the surface, printing is performed on the surface bonded to the bottom side of the lid member.
By the way, the bottom material and the lid material are welded to form a blister package, but it is difficult to align and weld the recesses formed on the bottom material and the symbols printed on the lid material without shifting. It was. Therefore, when printing is performed in the valleys of the pockets in PTP, so-called endless printing with no positional restriction is frequently used, and it is difficult to print symbols or the like corresponding to individual or several pockets. In the case of endless printing, there is very little information that can be displayed, and for example, it has not been possible to display a lot of information such as specifying the date and time of taking each individual drug.
[0005]
[Problems to be solved by the invention]
Therefore, the present inventor has completed the present invention as a result of various studies to solve the above-mentioned problems, and the present invention avoids the above-mentioned contamination and does not cause the interaction with the medicine or food. An object is to provide such a blister bottom material. It is another object of the present invention to provide a printed blister bottom material which can display characters, symbols, etc. in detail without performing double-sided printing on a cover material such as paper or aluminum foil, and which can be applied to individual pockets.
[0006]
The gist of the present invention is a blister bottom material formed by laminating a plurality of resin layers and having visibility of stored items, the positional relationship between the pockets between the resin layers is controlled, and can be read from the bottom material side , It is a blister bottom material which has a colored layer characterized by having a colored layer containing detailed indications, such as a symbol . That is, in the present invention, since a colored layer is contained between a plurality of resin layers, it is possible to prevent the occurrence of contamination due to the pigment or dye remaining in the extruder or the T-die. Incorporated into ink or adhesive and laminated between resin layers prevents pharmaceuticals and foods from coming into direct contact with pigments and dyes, thereby avoiding the interaction of pharmaceuticals and foods and improving the safety of pharmaceuticals and foods It is a secured blister bottom material.
[0007]
DETAILED DESCRIPTION OF THE INVENTION
The present invention will be described in more detail.
The blister bottom material according to the present invention comprises a plurality of resin layers of polyolefins such as polypropylene (PP), polystyrene and cyclic polyolefin, and polyesters such as polyethylene terephthalate (PET). These resin layers may be different from each other. For example, a combination of different resins such as PP and A-PET (amorphous polyester) may be used, but from the viewpoint of easy disposal such as recycling, disposal, and incineration. It is preferable that it consists of resin which has a common resin as a main component. The common resin layer is preferably a polypropylene resin or a polyester resin. In other words, vinyl chloride is the mainstream of conventional blister bottom materials, but the generation of chlorine gas at the time of incineration has become a problem. On the other hand, polypropylene resins and polyester resins can generate chlorine gas at the time of incineration. It is preferable from the viewpoint of environmental problems, and a polypropylene resin is preferable because it is excellent in moisture resistance.
An additive or the like may be added to the resin for the purpose of improving moldability.
[0008]
As described above, in the blister bottom material in the present invention, a colored layer obtained by applying a paint containing a pigment such as a pigment or a dye between the resin layers is present. By adopting such a laminated structure, the blister bottom material of the present invention has no fear of rubbing and falling, for example, as compared with the case where a printing layer is provided on the side where the contents of the blister bottom material are not stored. Even if the blister bottom material is wound and stored, there is no transfer of pigments or dyes to the opposite surface, and separation from stored items is certain. Moreover, there is no restriction | limiting in particular about the pigment | dye used by this invention, A well-known pigment and dye can be used suitably. The pigment does not elute and has high hygiene safety, and since many dyes are excellent in compatibility with the resin, the pigment is uniformly dispersed and hardly disturbs visibility.
[0009]
As a means for forming the colored layer, an ink containing a dye and / or a pigment is applied using a printing machine, or an adhesive containing a dye and / or a pigment is used for dry lamination, Or the resin layer for adhesion | attachment containing a pigment | dye and / or a pigment is performed by extrusion lamination. When applying using a printing machine, it is preferable to apply using a gravure roll because uniform application can be achieved, the amount of application can be easily adjusted, and detailed partial coating is possible. Since detailed partial coating can be performed in this manner, for example, various information can be displayed on the bottom material itself in blister packaging. For example, the pocket part is a thin solid print that does not interfere with the visibility of stored items, and the printing is mainly based on the distinctiveness of the contents. It becomes possible to print in detail.
[0010]
And it is preferable that such a printing layer is formed in a 200 micrometers-10 micrometers resin film. Further, it is more preferable to form a resin film of 50 μm to 10 μm. A resin film of 50 μm to 10 μm is easy to handle because it is rich in flexibility, and is usually handled by roll-shaped winding, but it can be wound up in a long length and has excellent workability. Furthermore, when forming the printed layer, it is preferable to insert a so-called photoelectric tube mark (eye mark) having a linear portion that allows the photoelectric tube to be detected in a part of the design. In this way, when the pocket portion of the blister package is formed, the photoelectric tube mark can be traced by the photoelectric tube of the molding machine, and the positional relationship between the pocket and the printing pattern can be accurately controlled. Specifically, this is possible by applying the method described in JP-B-6-62129 to the bottom material of the present invention. At this time, the pitch is controlled by printing photoelectric tube marks on the bottom material sheet at a pitch shorter than the bottom pitch, softening the bottom material with a preheating heater, and applying a controlled tension to the bottom material sheet at that time. Therefore, the deviation can be corrected.
By controlling in this way, it is possible to display symbols and the like that have been conventionally displayed on the cover material by endless printing in correspondence with each pocket, so that the amount of information that can be displayed dramatically increases.
[0011]
When performing dry lamination, it is preferable for the same reason that a gravure roll is set on a dry laminator for coating. In addition, a known coating method such as Mayer bar coating or reverse roll coating can be applied.
When dry laminating using an adhesive, an isocyanate, urethane, acrylic, or other adhesive can be used as the adhesive.
[0012]
The color of the pigment or dye used in the present invention is not particularly limited, but when the pocket is colored, a light having a short wavelength region that is likely to adversely affect the contents packaged using red or white is used. You may make it cut off. At that time, it is effective to use an ultraviolet absorber in combination.
Examples of dyes having such a function that can be used in the colored layer include inorganic pigments such as zinc white, titanium oxide pigments, lithophone pigments, zinc sulfide, and azo, anthraquinone, heterocyclic, methine, and perinone pigments. Specific examples of organic pigments include dyes such as azo pigments such as Lake Red C and Lake Red D. In addition, as the ultraviolet absorber, those generally used in plastic molding, for example, benzophenone-based sea soap 101 (manufactured by Sipro Kasei Co., Ltd.), benzotriazole-based tinuvin P (manufactured by Ciba Geigy), salicylate Bio soap 90 (manufactured by Kyodo Yakuhin Co., Ltd.), cyanoacrylate bio soap 910 (manufactured by Kyodo Yakuhin Co., Ltd.), and the like. The amount of these used in the ultraviolet blocking layer is 0 to 8 parts, more preferably 0.01 to 5 parts, per 100 parts by weight of ink or adhesive. In the present invention, in addition to the above-mentioned pigments, additives such as fillers and lubricants that are usually blended in plastic inks or adhesives may be added to the printing layer.
[0013]
In the case of a two-layer PTP bottom material composed of a polypropylene resin layer as an example in the present invention, for example, a printing layer containing a dye is present on the surface of a polypropylene sheet (A) having a thickness of 10 to 200 μm, A polypropylene sheet (B) having a thickness of 50 to 400 μm is laminated on the printed layer so that the total thickness is 150 to 500 μm. The thickness of the polypropylene sheet (A) is about 10 to 200 μm, and if it is thinner than 10 μm, the interaction with the pharmaceutical cannot be sufficiently prevented. However, it is not preferable because it becomes hard and the workability is lowered, and when it is wound into a roll, it is difficult to make the length longer. The polypropylene sheet (B) may be a sheet having a multilayer structure of two or more layers such as coextrusion depending on circumstances.
[0014]
FIG. 1 is a perspective view of a conventional PTP package, and FIG. 2 is a cross-sectional view of a PTP package using a blister potom material according to the present invention. FIG. 3 shows an example of a laminated structure of blister potom materials according to the present invention.
In FIG. 1, a large number of recesses (pockets) 3 are provided in a transparent polypropylene sheet 1, a capsule-like tablet 4 is accommodated in the pocket 3, and a lid material 2 is bonded thereon. Therefore, in the PTP packaging of the blister pottom material according to the present invention, as shown in FIG. 2, the polypropylene sheet 1 has the printing layer 5 interposed between the polypropylene sheet A and the polypropylene sheet B. FIG. 3 shows an example of a laminated structure of blister pottom materials according to the present invention, in which a printing layer 6 and an adhesive layer 7 are provided on a polypropylene sheet A, and a polypropylene sheet B is laminated via the adhesive layer. To do.
Next, the present invention will be specifically described with reference to examples.
[0015]
【Example】
Example 1
(1) Black and orange inks containing polyurethane-vinyl chloride / vinyl acetate pigments after corona discharge treatment on one side of a 50 μm unstretched polypropylene sheet having a melting point of 162 ° C. and a yield strength of 3.0 kgf / mm ² About 1.1 g / m ² was subjected to gravure printing. The letters and the photoelectric tube mark in the lower left corner were black, and then the whole was orange solid print. Gravure printing was performed by overlaying 0.8 to 5.0 g / m ^{2 of} an ink containing a similar white pigment to form a printed layer as shown in FIG.
(2) About 3.0 g / m ² of polyester polyurethane adhesive was applied to the white ink printing surface, and 250 μm polypropylene sheet (25 μm melting point 162 ° C. polypropylene and 200 μm melting point 162 ° C. polypropylene aromatic This was bonded to the corona discharge treated surface of a two-kind three-layer coextruded sheet of a mixture of petroleum hydrocarbon resin and 25 μm polypropylene having a melting point of 162 ° C.
(3) This sample was molded into PTP pockets with a PTP blister packaging machine equipped with a preheater heater with a phototube as a test. Numbers on the top of each pocket and katakana on the side were accurate for each pocket. The roman letters were printed at appropriate positions for the six pockets.
(4) In addition, the delamination strength of the 50 μ polypropylene film and the 250 μ polypropylene sheet of this sample has a strength of 400 gf / 25 mm or more at a speed of 300 mm / min and a peeling angle of 180 degrees, and can be peeled off even when molding a PTP packaging machine. Did not occur.
[0016]
【The invention's effect】
As described above, in the present invention, by providing a colored layer between a plurality of resin layers, it has been possible to avoid contamination that has conventionally occurred when coloring a blister bottom material. Traditionally, printing has been performed on both sides of cover materials such as paper and aluminum foil, but detailed display of characters, symbols, etc. is possible without such double-sided printing, and it is also possible to handle individual pockets. A blister bottom material with a print can be provided.
[Brief description of the drawings]
FIG. 1 is a perspective view of a PTP. FIG. 2 is a cross-sectional view of PTP packaging using the blister bottom material of the present invention. FIG. 3 shows a laminated structure of an example of a blister bottom material according to the present invention.
4 is a plan view of a blister bottom material provided with a printing layer in Example 1. FIG.
[Explanation of symbols]
DESCRIPTION OF SYMBOLS 1 Polypropylene sheet 2 Cover material 3 Concave part 4 Capsule-shaped tablet 5 Colored layer 6 Printing layer 7 Adhesive layer

Claims (5)

This is a blister bottom material that has multiple resin layers and has visibility of stored items. The positional relationship with the pocket is controlled between the resin layers, and detailed display of characters and symbols that can be read from the bottom material side. blister bottom material having a colored layer characterized by having a colored layer containing. The blister bottom material having a colored layer according to claim 1, wherein the plurality of resin layers are made of a resin whose main component is a common resin. The blister bottom material having a colored layer according to claim 1 or 2, wherein the common resin is polypropylene. The blister bottom material having a colored layer according to any one of claims 1 to 3 , wherein the colored layer is a printed layer formed on a resin film having a thickness of 200 µm or less. 5. The blister bottom material having a colored layer according to claim 4, wherein a photoelectric tube mark is printed on the printed layer.

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