JP3436821B2 - Hair cosmetics - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair cosmetic composition capable of imparting a good feel to hair and suppressing or repairing hair damage.

[0002]

2. Description of the Related Art In recent years, along with the individualization of fashion, the tendency toward longer hair has been steadily established, and in addition to this, a variety of long styles are being developed by beauty treatment such as partial perm. But on the other hand,
Damage to hair such as split ends and cut hair is also steadily increasing. It is considered that such damage to the hair is caused by denaturation of the keratin protein by chemical treatment such as perm, which weakens the hair structure and makes it easier to be physically affected by drier, brushing and the like.

As a means for preventing such damage to hair, collagen and keratin protein are used for the purpose of coping with deterioration of protein structure due to chemical treatment, forming a protective film on the hair surface, imparting moisturizing properties, and improving elasticity. It is known that the above ingredients are blended with a hair care agent (for example, JP-A-61-28).
0413 publication). Further, for the purpose of reducing the frictional force on the hair surface, hair rinses, hair treatments, brushing agents, setting agents and the like, which contain oil components such as higher alcohols, ester oils, liquid paraffin and silicone oils, are known. However, it cannot be said that a hair care agent containing collagen, keratin protein or the like has a sufficient hair damage preventing effect. In addition, even with products containing various oil components, it cannot be said that there is a sufficient friction reducing effect on already damaged hair, and when the amount of oil components is increased to improve the effect, a sticky feeling or It becomes more oily and impairs the feeling of use.

As a solution to such a problem, a hair care agent containing a polymer emulsion as a hair conditioning agent is known (Japanese Patent Laid-Open No. 62-63).
No. 508). Since this polymer emulsion is adsorbed on the hair in the form of fine particles, the adsorption amount is larger and the effect is larger than that of a low molecular weight hair conditioning agent which is adsorbed at the molecular level. However, this polymer emulsion has no selectivity when adsorbed on hair, and may be adsorbed not only on damaged hair (hair from which the scalp is peeled) but also on healthy hair. As described above, the sound hair to which the polymer emulsion is adsorbed has a problem that the original smooth feel and natural texture of the hair are impaired at that portion. This problem becomes more remarkable as compared with the case of a low molecular weight hair conditioning agent, because the amount of adsorption of the polymer emulsion increases.

[0005]

As described above, conventional hair cosmetics do not always have a sufficient hair care effect, and in particular, many have insufficient hair damage control or repair effects. Therefore, in the present invention, by selectively adsorbing the particles in the polymer emulsion only to the damaged part of the hair, the damage of the hair can be suppressed or repaired while maintaining the original good properties of the undamaged hair. It can give flexibility, moistness, smoothness, etc. to the whole,
It is an object of the present invention to provide a hair cosmetic that can reduce the oily feel.

[0006]

Means for Solving the Problems As a result of intensive studies by the present inventors in order to achieve the above-mentioned object, as a result of mixing an antibody against hair obtained from egg yolk of poultry with a certain polymer emulsion, these components Each of them does not bind or adsorb to the hair alone, but the antibody adsorbs to the surface of the polymer emulsion, and surprisingly the polymer emulsion selectively adheres to a specific part of the hair due to the specificity of the antibody. The present invention has been completed by finding that the original feeling of the hair or the like is not impaired despite suppressing or repairing the damage.

The present invention relates to (a) an antibody to a hair or a hair extract obtained from egg yolk of a poultry immunized with the hair or a hair extract , and (b) a polymer of a vinyl monomer or
Select from copolymer, polyester resin and polyurethane
The present invention provides a hair cosmetic composition containing an emulsion of one or more polymers described above .

The antibody (a) used in the present invention is obtained from the yolk of eggs laid by the poultry by immunizing poultry with hair or a hair extract (see, for example, JP-A- 5-139935 ).

The hair or hair extract that serves as an antigen includes
Powder of whole hair or hair constituent tissues (hair scalp, fur, hair pulp, etc.) of healthy or damaged hair by perm etc. crushed to a length of 100 μm or less, or keratin protein extracted from the hair or hydration of keratin protein A decomposition product can be mentioned. Further, in order to obtain an antibody specific to damaged hair, the above-mentioned hair powder or keratin protein obtained by chemical treatment such as perm can also be used.

The method for crushing the whole hair or the hair-constituting tissue is not particularly limited, but it is disclosed in JP-A-57-1633.
The method described in JP-A No. 92, page 2, lower left column, line 4 to page 4, upper left column, line 12 and swelling hair with water, and then freeze-pulverizing can be applied. In addition, a method in which hair is treated with a protein denaturing agent such as lithium bromide, urea, or guanidine hydrochloride to swell, then frozen, and then pulverized with a pulverizer such as a mortar and a sand mill under liquid nitrogen can be applied. . The furry powder is first of all Proceeding of the 7th InternationalWool Te
xtile Research Conference Vol.4 (1985) 322 to 331 by removing the hair scalp by the Bantian treatment, etc.,
Next, it can be obtained by treating according to the crushing method of whole hair. In addition, the hair scalp powder is mechanically peeled by shaking the hair cut to 1 cm or less with sterile Teflon balls in sterile water, centrifuging, filtering, and freeze-drying the free hair scalp. It can be obtained by

As a method for extracting keratin protein from hair, mercaptoethanol, dithiothreitol,
A method of extracting with a protein denaturing agent such as urea, guanidine hydrochloride or sodium dodecyl sulfate in the presence of a reducing agent such as tributylphosphine or thioglycolic acid; and further, a keratin protein obtained by this method, iodoacetic acid, iodoacetamide, N- Methods such as blocking the thiol group with ethylmaleimide or fractionating the keratin protein by chromatography can be applied [Biochemistry and Physiology of the skin Edited
by Lowell A. Goldsmith, Vol.1 (1983) p.476, Oxford
University Press, Japan Dermatological Association Magazine, Volume 98 (1988
(Year) 619-620]. As a method for obtaining a hydrolyzate of a keratin protein, a hydrolysis method using an acid, alkali, or enzyme described in JP-A-57-85308, page 3, upper left column 7 to page 4, upper left column, line 12 Etc. can be applied.

As an immunizing method, various poultry may be injected subcutaneously, intraperitoneally, intramuscularly, etc .; added to feed or water for feeding; and forcibly orally administered. You can As the poultry used for immunization, chickens can be mentioned. The amount of antigen to be administered during immunization can be appropriately selected so that a desired antibody titer can be obtained within a range that does not adversely affect immune poultry. In addition, complete Freund's adjuvant (FC
An adjuvant such as A) or incomplete Freund's adjuvant (FIA) can also be used in combination.

Next, a method for collecting the antibody fraction (immunoglobulin) from egg yolk will be described.

As a method for collecting immunoglobulin from egg yolk, Proceeding of the Society for Experimental
Biology and Medicine Vol.126 (1967) 312 pages, Immunolo
gy Communications Vol.9 (1980) page 495, JP-A-3-14
The method described on page 3, upper right column, line 2 to lower left column, line 12 of 5500 Publication can be applied. An example of these methods will be described below. To the yolk separated from the egg,
A physiological phosphate buffer solution (PBS) of the same volume as this is added, and a lipid-soluble solvent such as chloroform or isopropyl alcohol is further added in an amount of 2 times to remove the lipid fraction. Crude purified immunoglobulin is obtained from the obtained aqueous layer by the ammonium sulfate fractionation method (crude purified antibody). Further, if necessary, fractionation with an ion exchanger or affinity exchanger, followed by gel filtration fractionation (purified antibody). Since these methods are sometimes accompanied by denaturation of immunoglobulin, they are disclosed in JP-A-64-3809.
It is preferable to apply the method (Production Example 2 described later) described in the lower left column, lines 8 to 15 of JP No. 8, page 5. The antibody (a) obtained as described above can be blended in a hair cosmetic composition in a solution state, but it is preferable to blend one concentrated by vacuum distillation or dried by freeze-drying.

The mixing ratio of the antibody (a) to the hair cosmetic composition varies depending on whether it is a purified antibody or a crudely purified antibody, but generally 0.001 to 50% by weight as a freeze-dried product is preferable.
In the case of a purified antibody, its lyophilized product is 0.001-
It is preferably 5% by weight, more preferably 0.005 to 1% by weight. If the blending ratio is less than 0.001% by weight, the effect is insufficient, and if it exceeds 5% by weight,
The effect corresponding to the increased amount cannot be expected to be improved, which leads to an increase in manufacturing cost, which is not preferable. In the case of a crudely purified antibody, its lyophilized product is preferably 0.01 to 50% by weight, more preferably 0.01 to 20% by weight.

In the polymer emulsion (b) used in the present invention, fine particles of a polymer are dispersed in water or an aqueous solution of an organic solvent by a stabilizing action of a surfactant, a protective colloid or a hydrophilic group of the polymer itself. It is a thing.

[0017] as a port Rimmer emulsion (b), the emulsion polymers that do not contain a silicon atom is preferable
Ku, one or two or more kinds polymers or copolymers of vinyl monomers, selected from the port Caixaforum <br/> button and a polyester resin
An emulsion of the above polymer is used .

Examples of vinyl monomers include (meth)
Examples thereof include acrylic acid, (meth) acrylic acid ester, (meth) acrylamide, ethylene, propylene, isoprene, butadiene, styrene and vinyl acetate. Examples of the vinyl-based monomer copolymers include copolymers of one or more of these vinyl-based monomers in any combination.

The polymer emulsion (b) used in the present invention is a method of forcibly emulsifying the above-mentioned polymer in water in the presence of a surfactant, adding water to a solution of a water-miscible organic solvent of the polymer, A method of precipitating a polymer in the form of fine particles, a method of neutralizing a solution of a water-miscible organic solvent containing a salt-forming group-containing polymer and then exchanging the solvent with water, and a method of self-emulsifying a hydrophilic / hydrophobic amphiphilic polymer in an aqueous medium. It can be obtained by a method or the like.

Examples of commercially available products of such polymer emulsion (b) include RESIN 125-221, Iodozol A-4540, (above, Kanebo NSC: acrylic acid ester-vinyl acetate copolymer), Ricabond ES. -23 (Chuo Rika Kogyo KK: acrylic ester-styrene copolymer), JSR-2108 (Nippon Synthetic Rubber Co., Ltd .: styrene-butadiene copolymer), JSR
-0668 (manufactured by Japan Synthetic Rubber Co., Ltd .: carboxy-modified styrene-butadiene copolymer), AE331 (manufactured by Japan Synthetic Rubber Co., Ltd .: carboxy-modified acrylic resin, average particle size 0.2)
~ 0.3 μm), E-5003 (manufactured by Nippon Paint Co., Ltd .: polybutyl acrylate microemulsion, average particle size 6)
0 nm), E-2002 (manufactured by Nippon Paint Co., Ltd .: polymethyl acrylate microemulsion, average particle size 30 n)
m), ADEKA BON TITER HUX-290H (manufactured by Asahi Denka Co., Ltd .: polyurethane emulsion, average particle size 2.0)
μm), ADEKA BON TITER HUX-240 (manufactured by Asahi Denka Co., Ltd .: polyurethane emulsion, colloid area),
Arolone 580 (Nippon Shokubai Co., Ltd .: short oily alkyd resin emulsion) and the like can be mentioned. Further, an emulsion obtained from Sun Wax E-300 (manufactured by Sanyo Kasei Co., Ltd .: emulsion low molecular weight polyethylene) and Nonipol 100 (manufactured by Nippon Shokubai Co., Ltd .: polyoxylennonyl phenyl ether) can also be used.

The size of the fine polymer particles in the emulsion is not particularly limited, but the average particle size is 0.0
It is preferably from 01 to 50 μm, and from 0.01 to 10 μm
And more preferably 0.01 to 5 μm. When the average particle size is less than 0.001 μm, the usability is not sufficiently improved, and when it exceeds 50 μm, the usability is deteriorated, which is not preferable.

The content of such an emulsion in the hair cosmetic composition is preferably 0.001 to 50% by weight, more preferably 0.01 to 10% by weight, still more preferably 0.01 to 5% by weight, as a dried product. Particularly preferred. If the blending ratio of the emulsion is less than 0.001% by weight, the effect becomes insufficient, and if it exceeds 50% by weight, the effect corresponding to the increase cannot be expected and the manufacturing cost increases. Not preferable.

In addition to the above components, the hair cosmetic composition of the present invention may further contain a surfactant, a cationic polymer, various silicone derivatives, and other known hair cosmetic components, if desired.

Examples of the surfactant include alkylbenzene sulfonate, alkyl ether sulfate, olefin sulfonic acid, α-sulfo fatty acid ester, amino acid surfactant, phosphoric acid ester surfactant, sforsuccinate ester surfactant. Anionic surfactants such as; Sulfonic acid type surfactants, betaine type surfactants, alkylamine oxides, amphoteric surfactants such as imidazoline type surfactants; polyoxyethylene alkyl ethers, polyoxyethylene alkylphenyl ethers, Alkanolamides and their alkylene oxide adducts, esters of polyhydric alcohols and fatty acids, sorbitan fatty acid esters, nonionic surfactants such as alkyl saccharide-based surfactants; mono- or di-linear long-chain alkyl No. 4
Examples thereof include cationic surfactants such as primary ammonium salts, mono- or di-branched linear long-chain alkyl quaternary ammonium salts, and one or more of these can be appropriately selected and used. Among these, when the hair cosmetic is a shampoo, considering the irritancy to the skin and hair, an amino acid-based surfactant, a phosphoric acid ester-based surfactant, a succinic acid ester-based surfactant, an imidazoline-based surfactant It is preferable to use a combination of an activator and an alkyl saccharide-based surfactant. The mixing ratio of these surfactants in the hair cosmetic composition is 0.01.
~ 40.0 wt% is preferred, 0.5-20.0 wt%
Is particularly preferable.

Examples of the cationic polymer include cationized cellulose derivative, cationized starch, cationized guar gum derivative, diallyl quaternary ammonium salt / acrylamide non-mixture, quaternized polyvinylpyrrolidone derivative, polyglycol-polyamine condensate and the like. These can be used alone or in combination of two or more. More specific examples of these cationic polymers include molecular weights of about 100,000 to 3,000,
Cationized cellulose of 000, degree of cationization about 0.0
1-1 cationized starch, degree of cationization about 0.01-1
Cationized guar gum (manufactured by Mayhol Co., Ltd .: Jaguar etc.), diallyl quaternary ammonium salt / acrylamide copolymer having a molecular weight of 30,000 to 2,000,000,
Quaternization of polyvinylpyrrolidone-dimethylaminoethyl methacrylate copolymer quaternized product having a molecular weight of 10,000 to 2,000,000 and a cationic nitrogen content in the vinyl polymer of 1.8 to 2.4% In addition to polyvinylpyrrolidone derivatives, polyglycol-polyamine condensates having an alkyl group having 6 to 20 carbon atoms, adipic acid / dimethylaminohydroxypropyldiethylenetriamine copolymer (manufactured by Sandos Inc .: caltaletin, etc.), JP-A-53-139734. Gazette, page 14, upper left column, line 5 to 37
Top right column, line 12 and JP-A-60-36407, No. 8
The cationic polymers described in page 16, upper right column, line 16 to page 10, lower left column, line 20 can be mentioned. The mixing ratio of these cationic polymers in the hair cosmetic composition is 0.0
5 to 20.0 wt% is preferable, 0.1 to 10.0 wt% is particularly preferable, and 0.1 to 5.0 wt% is the most preferable.

As the silicone derivative, dimethylpolysiloxane, methylphenylpolysiloxane, amino-modified silicone, alcohol-modified silicone, aliphatic alcohol-modified silicone, polyether-modified silicone,
Examples thereof include silicone derivatives such as epoxy-modified silicone, fluorine-modified silicone, cyclic silicone, and alkyl-modified silicone, and one or more of these can be appropriately selected and used. Further, these silicone derivatives are disclosed in Japanese Patent Publication No. 56-38609, No. 3
It can also be used as a latex composition emulsion-polymerized by the method described on page 6, column 29 lines 43. Among these silicone derivatives, dimethylpolysiloxane having a polymerization degree of 500 or more, polyether-modified silicone, amino-modified silicone, and cyclic silicone are preferable because they can give a good feel to hair. The blending ratio of these silicone derivatives in the hair cosmetic composition is 0.01-.
20.0% by weight is preferred, 0.05-10.0% by weight
Is particularly preferable, and 0.1 to 5.0% by weight is the most preferable.

Other known hair cosmetic ingredients include:
Texture improvers such as higher fatty acid salts, alkylamine oxides, fatty acid alkanolamides, squalane, lanolin, α-monoisostearyl glyceryl ether, cholesteryl sulphate; propylene glycol, glycerin, sorbitol, JP-A-64-9913. General formula of;

[0028]

[Chemical 1]

[In the formula, R ¹ represents a linear or branched saturated or unsaturated hydrocarbon group having 10 to 26 carbon atoms, and R ² represents a linear or branched saturated or unsaturated hydrocarbon group having 9 to 25 carbon atoms. An amide derivative represented by an unsaturated hydrocarbon formula, wherein X represents (CH ₂ ) _m (where m represents an integer of 2 to 6), the following general formula (2);

[0030]

[Chemical 2]

(Wherein R ³ represents a hydrogen atom or a methyl group and R ⁴ represents an alkyl group having 1 to 5 carbon atoms), such as a moisturizing agent such as a dialkylene glycol monoalkyl ether; methyl cellulose, carboxy Viscosity modifiers such as vinyl polymer, hydroxyethyl cellulose, polyoxyethylene glycol distearate, and ethanol; pearling agents; fragrances; dyes; UV absorbers; antioxidants; bactericides such as triclosan and trichlorocarban;
Anti-inflammatory agents such as potassium glycyrrhizinate and tocopherol acetate; antidandruff agents such as zinc pyrithione and octopirox; preservatives such as methylparaben and butylparaben; aminopolycarboxylic acid derivatives such as ethylenediaminetetraacetic acid as chelating agents; benzyl alcohol, A permeation enhancer such as benzyloxyethanol may be mentioned.

The pH of the hair cosmetic composition of the present invention is 3 to 10.
Those having 4 to 8 are particularly preferable. The dosage form of the hair cosmetic composition of the present invention is not particularly limited, and is appropriately selected from dosage forms such as an aqueous solution, an ethanol solution, an emulsion solution, an emulsion, a suspension, a gel, a liquid crystal, a solid, and an aerosol according to the purpose of use. be able to. Further, the hair cosmetic composition of the present invention includes a pre-shampoo agent, shampoo, hair rinse, hair conditioning agent, hair treatment, set lotion, blow styling lotion, hair spray, foamy styling agent, gel styling agent, hair liquid, hair tonic. , Hair cream, first permanent wave agent, second permanent wave agent, permanent hair dye, temporary hair dye, and the like.

[0033]

The present invention will be described in more detail with reference to the following examples, but the present invention is not limited thereto.

Production Example 1 (Production of Hair Antigen) (1) Production of Coarse Hair Powder Healthy hair or perm-treated hair is dipped in an aqueous solution of 11M lithium bromide and treated with hot water at 90 ° C. for 90 minutes to swell and rubber. Denatured. Next, excess liquid was removed from the treated hair using a nylon net, transferred to a mortar pre-cooled, and frozen with liquid nitrogen. Then, while supplementing with liquid nitrogen as appropriate, the product was ground with a pestle in a frozen state for 3 hours. Next, the crushed hair was transferred to a centrifuge tube, washed with ion-exchanged water, and then centrifuged to collect the hair. This was repeated 3 times to completely wash away lithium bromide from the hair to obtain coarse hair powder (average particle size 100 μm or less).

(2) Production of fine hair powder The above coarse hair powder and ion-exchanged water were added to a centrifuge tube, shaken vigorously and dispersed, and then allowed to stand for 1 minute. Then, a supernatant containing fine powder was collected, and the same operation was repeated for the rest. The fine powder thus collected was dispersed in distilled water (1% by weight) and the mixture was mixed with a French press.
After pulverizing 3 times at a pressure of 00 psi, it was freeze-dried to obtain a fine hair powder (average particle diameter 10 μm or less).

(3) Preparation of hair dermis powder First, hair was shredded to 1 cm or less, excess sebum was removed using hexane, and sterilized with 70% ethanol. Next, 100 ml of ion-exchanged water was added to a Sakaguchi flask and sterilized by an autoclave, and 20 Teflon spheres having a diameter of about 12 mm sterilized with 70% ethanol and 2 g of the above-mentioned sterilized hair were added. After that, do this at 150 rpm.
The culture was shaken for a day. Next, the ion-exchanged water that became cloudy in the peeled hair dermis was collected and freeze-dried to obtain hair dermis powder.

(4) Production of fur (including hair pulp) powder Hair was immersed in 36 ppm nickel chloride aqueous solution at 25 ° C. for 10 seconds and then immediately rinsed with ion-exchanged water. After that, this hair was treated with an aqueous solution of hypochlorous acid (a solution of about 5% chlorine was adjusted to pH 6.5 with concentrated hydrochloric acid) at 20 ° C. for 2 minutes to crush the hair dermis by an oxygen explosion, Immediately rinse with deionized water. Next, it was treated with a 0.5% by weight sodium pyrosulfate solution (pH 9.5) at 20 ° C. for 2 minutes to remove residual chlorine, and the hair scalpel was scraped off in warm ion-exchanged water. Then, the hair was soaked in a 0.1N acetic acid solution for 1 minute, rinsed with cold ion-exchanged water, and dried to obtain hair from which the hair scalp was removed. This hair was freeze-pulverized in the same manner as in the above (1) to obtain fur powder.

(5) Production of Hair Extraction Keratin Protein Hair was shredded to a size of 3 mm or less, and 8 M urea and 200 mM 2
-A 200 mM Tris-hydrochloric acid buffer solution (pH 9.0) containing mercaptoethanol was added, and the mixture was cultured at 40 ° C for 2 hours in a nitrogen atmosphere. Next, after mashing with a Teflon homogenizer, it was further cultured at 40 ° C. for 2 hours. 1 of this culture
The supernatant was collected by centrifugation at 30,000 × G for 30 minutes. Thereafter, the supernatant was reacted with an iodoacetic acid solution under the condition of pH 8.0, and 2-mercaptoethanol was added to stop the reaction. The reaction solution was dialyzed against ion-exchanged water for 2 days and freeze-dried to obtain a hair keratin protein sample. This sample was again dissolved in urea, 2-mercaptoethanol and Tris-hydrochloric acid buffer solution, and dialyzed with Tris-hydrochloric acid buffer solution (pH 7.4) containing 0.1% sodium dodecyl sulfate to obtain hair keratin protein.

Production Example 2 (1) Production of hen egg antibody The hair obtained in (1) to (5) of Production Example 1, the powder of the hair constituting tissue and the extracted keratin protein were respectively dispersed in physiological saline and complete Freund's. Chickens were hyperimmunized using a mixture with an adjuvant (1 mg / ml intramuscular injection x
4 times). Antibodies were obtained from the eggs produced by this chicken by the following method. First, the egg yolk of the egg was set to 1 volume, and this was mixed with 5 volumes of a 1.5 mg / ml λ-carrageenan aqueous solution. Next, the produced lipoprotein aggregates were removed by centrifugation to obtain 5 types of supernatant liquids. These supernatants are about 8
It contained egg yolk antibody at a recovery rate of 0%.

(2) Production of purified egg yolk antibody Using the 5 kinds of supernatant obtained in (1) above, 5 kinds of purified egg yolk antibodies (17% (w / V) sodium sulfate salt out) was obtained.

Production Example 3 (1) Production of Self-Dispersion Acrylic Resin Emulsion In a reaction vessel equipped with a stirrer, a reflux condenser, a dropping funnel, a thermometer and a nitrogen introducing tube, isopropyl alcohol 500 was added.
By weight, 314 parts by weight of ethyl acrylate, 85 parts by weight of ethyl methacrylate, 65 parts by weight of dimethylaminoethyl methacrylate and 86 parts by weight of methacrylic acid were charged, and the inside of the container was replaced with nitrogen gas. 0.5 parts by weight of bisisobutyronitrile was added, and the mixture was polymerized at 80 ± 2 ° C. for 7 hours to obtain a copolymer. Next, 250 parts by weight of isopropyl alcohol was added to the copolymer for dilution, and then 150.7 parts by weight of 1N sodium hydroxide was added to neutralize the copolymer. Then, add 2500 parts by weight of deionized water,
Isopropyl alcohol was distilled off at 50 ° C. or lower under reduced pressure to obtain a self-dispersion emulsion. The average particle size of this emulsion was 0.03 μm.

(2) Production of emulsion by emulsion polymerization method In the same reaction vessel as in (1), 150 parts by weight of water, 2 parts by weight of sodium dodecylbenzenesulfonate, 0.5 parts by weight of ammonium persulfate, 55 parts by weight of methyl methacrylate. , N-butyl acrylate 33 parts by weight, styrene 10 parts by weight,
2 parts by weight of acrylic acid, 5 parts by weight of dibutyl phthalate and 2.5 parts by weight of dodecyl mercaptan were charged, and the inside of the container was replaced with nitrogen gas and dissolved oxygen was also removed. next,
While stirring, the temperature inside the container was raised to 70 ° C., and polymerization was performed for 3 hours. Furthermore, after aging at the same temperature for 3 hours, a small amount of aggregate was removed to obtain an emulsion having a solid content of 41%. The average particle size of this emulsion was 0.12 μm.

(3) Production of polyester emulsion In a reaction vessel equipped with a stirrer, a cooler, a receiver, a thermometer and a nitrogen inlet tube, 108 parts by weight of dimethyl terephthalate, 37 parts by weight of ethylene glycol, polyethylene glycol (# 4000). ) 450 parts by weight and antimony trioxide 0.
3 parts by weight was charged, and the inside of the container was replaced with nitrogen gas.
Then, blow nitrogen gas and stir 240 while stirring.
The temperature was raised to 0 ° C., and the esterification reaction was carried out at normal pressure for 5 hours. The hydroxyl group value of this reaction product was 28.0, and the weight average molecular weight determined by gel filtration analysis was 3,900. Next, 480 parts by weight of ion-exchanged water was added to 120 parts by weight of this reaction product, and the mixture was emulsified and dispersed at 60 ° C. for 2 hours to obtain an emulsion having a solid content of 20.5%. The average particle size of this emulsion was 8 μm.

Example 1 (Production of Hair Treatment) Hair cosmetics (hair treatment) of the present invention of 1 to 12 shown in Tables 1 and 2 below and 13 to 1 as comparative examples.
5 hair treatments were produced. These hair treatments were tested for softness, oiliness, moistness, smoothness and split hair generation. The results are shown in Table 1,
It shows in Table 2.

(Test method) 20 g (about 15 to 20 cm) of hair of a Japanese woman was bundled and washed with an ordinary shampoo.
2 g of each hair treatment of Examples and Comparative Examples was uniformly applied to this hair, and then rinsed with running water for 30 seconds. In the case of continuous treatment, 2 g of each hair treatment of Comparative Example was uniformly applied after running water, and then rinsed under running water for 30 seconds. Then, it was towel dried and further dried with a dryer. Each test item of the dried hair was evaluated according to the following criteria.

Flexibility A: Very soft. ○: Soft Δ: Neither can be said. X: Hard. Oily feeling ◎: Very little. ○: Little. Δ: Neither can be said. X: Many. Moist feeling ◎: Very moist. ○: Slightly moisturized. Δ: Neither can be said. ×: It is dry. Smoothness ◎: Very smooth. ○: Smooth. Δ: Neither can be said. X: Squeaky. Split hair occurrence ◎: Very low. ○: Little. Δ: Neither can be said. X: Many.

[0047]

[Table 1]

[0048]

[Table 2]

(Test Results) As is clear from Tables 1 and 2, the hair treatments of the products 1 to 12 of the present invention containing both the component (a) and the component (b) have excellent softness to hair, It imparted a moist feeling and smoothness, had less oiliness, and had less split ends. On the other hand, the comparative products 13 to 15 containing only one of the component (a) and the component (b) did not have sufficient effects. Further, even if the continuous treatment with Comparative Product 13 and Comparative Product 14 or the continuous treatment with Comparative Product 13 and Comparative Product 15 was not obtained, the effect of the present invention was obtained as Component (a). It can be seen that the composition is the first to be obtained as a composition containing both the component (b).

Example 2 (Production of shampoo) 16 to 21 of the hair cosmetic composition (shampoo) of the present invention shown in Table 3 below and 20, 21 of shampoo as comparative examples were produced. These shampoos were tested according to Example 1 for flexibility, oiliness, moistness, smoothness, and split ends generation. As a result, as shown in Table 3, even in the case of shampoo, good results were obtained only in the case of the composition of the present invention containing both the component (a) and the component (b).

[0051]

[Table 3]

Example 3 In order to prove that the egg yolk antibody to the hair specifically (selectively) adsorbs the particles in the polymer emulsion at the damaged site of the hair, a fluorescent dye-containing polystyrene latex was used as the polymer emulsion, and a fluorescence microscope was used. Observed by. As an egg yolk antibody, a fluorescent dye-containing polystyrene latex (manufactured by Polyscience, average particle diameter 3 μm) was mixed with an aqueous solution containing 0.01% by weight of the egg yolk antibody of Production Example 2 (1) so as to be 0.05% by weight, Incubated at room temperature for 30 minutes. The hair damaged by the perm was dipped in this culture solution and further cultured for 30 minutes. After washing well with water,
After drying, the polystyrene latex on the hair was observed with a fluorescence microscope. As a control, an egg collected from a chicken that was not immunized with hair powder was used, and purification was performed in the same manner as in Production Example 2. Damaged hair was treated with egg yolk antibody as described above.

As a result, as shown in FIGS. 1 and 2, when the yolk antibody immunized against the hair and the polystyrene latex were contained, the polystyrene latex was adsorbed much on the part where the hair was damaged and the fur was exposed. When the control yolk antibody was used, it was hardly adsorbed on the hair. Therefore, it was found that the egg yolk antibody of the hair specifically adsorbs the particles of polystyrene latex to the damaged site of the hair.

Example 4 A hair rinse having the following composition was produced by a conventional method.

[0055]

[Table 4] (Composition) (wt%) Di (2-hexadecyl) dimethylammonium chloride 2.0 Cetyltrimethylammonium chloride 2.0 Chloride (myristoylaminoethyl-N-hydroxyethyl)   Amino-2-hydroxypropyl trimethyl ammonium 1.0 Cetyl alcohol 5.0 Polyoxyethylene (EO 5) oleyl ether 0.4 Dimethyl polysiloxane (Polymerization degree 1000) 0.5 Pentaerythritol glyceryl / isostearyl glycidyl   1 mol addition product of ether 0.1 Antibody of Production Example 2 (1) (Antigen: Coarse hair powder of Production Example 1 (1)) 0.2 E-5003 (Butyl acrylate microemulsion,   Average particle diameter 60 nm) 0.5 Liquid paraffin 1.0 Hydroxyethyl cellulose (1% aqueous solution, viscosity 8000 cP) 0.3 Methylparaben 0.2 Fragrance 0.2 Purified water balance                                                           100 in total

This hair rinse was excellent in smoothness and flexibility, had little oily feel, and was able to impart a moist and good feel to the hair.

Example 5 A hair treatment having the following composition was produced by a conventional method.

[0058]

[Table 5] (Composition) (wt%) Di (2-hexadecyl) dimethylammonium chloride 2.0 Cetyltrimethylammonium chloride 2.0 Cetyl alcohol 5.0 Antibody of Production Example 2 (1) (Antigen: Coarse hair powder of Production Example 1 (1)) 0.7 ADEKA BON TITER HUX-290H   (Polyurethane emulsion, average particle size 2.0 μm) 0.5 Polyoxyethylene (EO 5) oleyl ether 0.4 Hydroxyethyl cellulose (1% aqueous solution, viscosity 8000 cP) 0.3 Methylparaben 0.2 Fragrance 0.2 Purified water balance                                                           100 in total

This hair treatment was excellent in smoothness and flexibility, had little oily feel, and was able to impart a moist and good feel to the hair.

Example 6 A hair shampoo having the following composition was produced by a conventional method.

[0061]

[Table 6] (Composition) (wt%) Polyoxyethylene (EO 2.5) lauryl ether   Sulfate sodium salt 15.0 Coconut oil fatty acid diethanolamide 3.0 Antibody of Production Example 2 (2)   (Antigen: keratin protein extracted from hair of Production Example 1 (5)) 0.7 Cationized cellulose (molecular weight about 200,000) 0.5 AE331 (carboxy modified acrylic emulsion;   Average particle diameter 0.2 to 0.3 μm) 0.1 SM8702C (amino-modified silicone, manufactured by Toray Silicone Co., Ltd.) 0.5 Propylene glycol 10.0 Fragrance 0.2 Dye Sodium hydroxide (pH adjusting agent) Purified water balance                                                           100 in total

This hair shampoo had excellent smoothness and flexibility, had little oiliness, and was able to impart a moist and good feel to the hair.

[0063]

EFFECTS OF THE INVENTION Since the hair cosmetic composition of the present invention contains the antibody (a) obtained by using hair or a hair extract as an antigen, the polymer emulsion (b) which is a conditioning component is excellent in the adsorptivity to hair. ing. Further, when the antibody (a) having damaged hair as an antigen is used, the polymer emulsion (b) is selectively adsorbed only on the damaged hair or the damaged portion. Therefore, when treated with the hair cosmetic composition of the present invention, excellent softness, moisturizing feel and smoothness can be imparted to dry hair, and oiliness can be reduced. At the same time, it also has an excellent effect of preventing and repairing split ends. These effects are not lost by routine hair washing.

[Brief description of drawings]

FIG. 1 is a micrograph showing the adsorption state of polystyrene latex when a control yolk antibody is used.

FIG. 2 is a micrograph showing the adsorption state of polystyrene latex when a composition containing a hair yolk antibody and polystyrene latex is used.

─────────────────────────────────────────────────── ─── Continuation of front page (72) Inventor Hiroshi Nojiri 4-chome, Yanase 11-3-104, Utsunomiya City, Tochigi Prefecture (72) Inventor Yukio Naito 1463-1, Hanamuro, Tsukuba City, Ibaraki Prefecture (72) Inventor Michitaka Sawada Wakayama 727-120 Zenmyoji, Wakayama City, Japan (72) Inventor Genji Imokawa 1027-89 Himurocho, Utsunomiya City, Tochigi Prefecture (72) Hidehisa Takahashi 9-5 Akahori Shinmachi, Yokkaichi City, Mie Prefecture Taiyo Kagaku Co., Ltd. (72) Inventor Toshinori Kobayashi 9-5 Akahori Shinmachi, Yokkaichi-shi, Mie, Taiyo Kagaku Co., Ltd. (56) Reference JP-A-6-80537 (JP, A) JP-A-6-56624 (JP, A) JP-A-62 -63508 (JP, A) JP-A-5-163123 (JP, A) JP-A-5-155741 (JP, A) JP-A-5-155740 (JP, A) JP-A-5-155739 (JP, A) ) JP-A-5-139935 (JP, A ) (58) Fields surveyed (Int.Cl. ⁷ , DB name) A61K ^7/ 00-7/50

Claims (9)

(57) [Claims] 1. (a) An antibody against a hair or a hair extract obtained from egg yolk of a poultry immunized with the hair or a hair extract , and (b) a polymer or copolymer of a vinyl monomer.
1 selected from body, polyester resin and polyurethane
Hair cosmetic containing an emulsion of one or more polymers . 2. The hair cosmetic composition according to claim 1, wherein the antigen used for immunization is selected from a crushed product of whole hair, a crushed product of scalp, a crushed product of fur, a keratin of hair and a hydrolyzed product of keratin for hair. 3. The vinyl-based monomer is (meth) acrylic acid, (meth) acrylic acid ester, (meth) acrylamide, vinyl acetate, ethylene, styrene, propylene,
The hair cosmetic composition according to claim 1, wherein those selected from butadiene and isoprene. 4. The polymer emulsion (b) comprises a polymer of a monomer selected from (meth) acrylic acid, (meth) acrylic acid ester and (meth) acrylamide, a copolymer thereof or a monomer thereof and another monomer. The hair cosmetic composition according to claim 1, which is an emulsion of one or more polymers selected from the group consisting of a copolymer of :, polyurethane; and polyester. 5. The hair cosmetic composition according to claim 1, which further comprises (c) a surfactant. 6. The hair cosmetic composition according to claim 1, further comprising (d) a silicone derivative. 7. The hair cosmetic composition according to claim 1, which further comprises (e) a cationic polymer. 8. The antibody (a) in an amount of 0.001 to 50% by weight,
The hair cosmetic composition according to claim 1, which contains 0.001 to 50% by weight of the polymer emulsion (b) as a dried polymer. 9. A hair cosmetic composition comprising a pre-shampoo agent, shampoo, hair rinse, hair conditioner, hair treatment, set lotion, blow styling lotion, hair spray, foamy styling agent, gel styling agent, hair liquid, hair tonic, The hair cosmetic composition according to claim 1, which is selected from a hair cream, a permanent wave first agent, a permanent wave second agent, a permanent hair dye and a temporary hair dye.