JP3268782B2 - ホスファターゼ阻害剤およびその使用方法 - Google Patents

ホスファターゼ阻害剤およびその使用方法

Info

Publication number
JP3268782B2
JP3268782B2 JP50912898A JP50912898A JP3268782B2 JP 3268782 B2 JP3268782 B2 JP 3268782B2 JP 50912898 A JP50912898 A JP 50912898A JP 50912898 A JP50912898 A JP 50912898A JP 3268782 B2 JP3268782 B2 JP 3268782B2
Authority
JP
Japan
Prior art keywords
group
compound
cells
divalent
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP50912898A
Other languages
English (en)
Japanese (ja)
Other versions
JP2000515165A (ja
Inventor
ラゾ，ジョン，エス．
ライス，ロバート，エル．
クニンガム，エイプリル
ワイプ，ピーター
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pittsburgh
Original Assignee
University of Pittsburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pittsburgh filed Critical University of Pittsburgh
Publication of JP2000515165A publication Critical patent/JP2000515165A/ja
Application granted granted Critical
Publication of JP3268782B2 publication Critical patent/JP3268782B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP50912898A 1996-07-30 1997-07-30 ホスファターゼ阻害剤およびその使用方法 Expired - Fee Related JP3268782B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/688,530 US5700821A (en) 1996-07-30 1996-07-30 Phosphatase inhibitors and methods of use thereof
US08/688,530 1996-07-30
US688,530 1996-07-30
PCT/US1997/013408 WO1998004257A1 (en) 1996-07-30 1997-07-30 Phosphatase inhibitors and methods of use thereof

Publications (2)

Publication Number Publication Date
JP2000515165A JP2000515165A (ja) 2000-11-14
JP3268782B2 true JP3268782B2 (ja) 2002-03-25

Family

ID=24764793

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50912898A Expired - Fee Related JP3268782B2 (ja) 1996-07-30 1997-07-30 ホスファターゼ阻害剤およびその使用方法

Country Status (8)

Country Link
US (4) US5700821A (en:Method)
EP (1) EP0959884A1 (en:Method)
JP (1) JP3268782B2 (en:Method)
AR (1) AR008120A1 (en:Method)
AU (1) AU715546B2 (en:Method)
CA (1) CA2261793A1 (en:Method)
IL (1) IL128217A0 (en:Method)
WO (1) WO1998004257A1 (en:Method)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6465250B1 (en) 2001-02-09 2002-10-15 Isis Pharmaceuticals, Inc. Antisense modulation of protein phosphatase 2 catalytic subunit alpha expression
US20040121973A1 (en) * 2002-02-05 2004-06-24 Monia Brett P Antisense modulation of protein phosphatase 2 Catalytic subunit alpha expression
US6602713B1 (en) * 2001-02-09 2003-08-05 Isis Pharmaceuticals, Inc. Antisense modulation of protein phosphatase 2 catalytic subunit beta expression
US7244622B2 (en) * 1996-04-03 2007-07-17 Applera Corporation Device and method for multiple analyte detection
US6989435B2 (en) 1997-09-11 2006-01-24 Cambridge University Technical Services Ltd. Compounds and methods to inhibit or augment an inflammatory response
US7067117B1 (en) 1997-09-11 2006-06-27 Cambridge University Technical Services, Ltd. Compounds and methods to inhibit or augment an inflammatory response
US6277566B1 (en) * 1998-02-13 2001-08-21 Phillip A. Beachy Method for identifying a hedgehog-mediated phosphorylation state dependent transcription factor
CA2325823A1 (en) * 1998-04-27 1999-11-04 University Health Network Gene screening methods and related assays
US7051360B1 (en) * 1998-11-30 2006-05-23 United Video Properties, Inc. Interactive television program guide with selectable languages
US7238711B1 (en) 1999-03-17 2007-07-03 Cambridge University Technical Services Ltd. Compounds and methods to inhibit or augment an inflammatory response
WO2000045852A1 (en) * 1999-02-03 2000-08-10 The Johns Hopkins University Method of treating cancer by restoration of pp32 function
WO2001010798A1 (en) * 1999-08-04 2001-02-15 Chemrx Advanced Technologies, Inc. Solid phase synthesis of oxa- and thiazoles
EP1226237A2 (en) * 1999-08-31 2002-07-31 Basf Aktiengesellschaft Method of identifying inhibitors of cdc25
WO2001027077A2 (en) * 1999-10-12 2001-04-19 Basf Aktiengesellschaft Hydroxysulfonylalkylene-, phosphonoalkylene- or difluoro(phosphononon)methyl- substituted benzene, or benzofuran derivatives as non-peptidic cdc25 inhibitors
WO2001083575A1 (en) * 2000-05-02 2001-11-08 Advanced Syntech, Llc A Kentucky Limited Liability Corporation A novel solid support template for preparation of highly functionalized heterocycle compounds
US20030027308A1 (en) * 2000-05-30 2003-02-06 Sugen Incorporated Novel human protein phosphatases identified from genomic sequencing
FR2812945B1 (fr) * 2000-08-10 2002-10-04 Aventis Pharma Sa Utilisation de la proteine grf1 et cellules exprimant la proteine grf1 pour le criblage de molecules
US20040157306A1 (en) * 2000-11-13 2004-08-12 Sugen Incorporated Mammalian protein phosphatases
WO2002070680A1 (en) * 2001-03-01 2002-09-12 Basf Aktiengesellschaft Method of identifying inhibitors of cdc25
US20030120073A1 (en) * 2001-04-25 2003-06-26 Seto Christopher T. Alpha-ketocarboxylic acid based inhibitors of phosphoryl tyrosine phosphatases
US20030124590A1 (en) * 2001-10-16 2003-07-03 Kosaku Uyeda Carbohydrate response element binding protein and uses thereof
JP2005509418A (ja) * 2001-11-13 2005-04-14 スージェン・インコーポレーテッド 哺乳動物蛋白質ホスファターゼ
AU2003220222A1 (en) * 2002-03-13 2003-09-29 Signum Biosciences, Inc. Modulation of protein methylation and phosphoprotein phosphate
US20050074831A1 (en) * 2002-03-19 2005-04-07 Jasna Jerecic Interaction of NMDA receptor with protein serine threonine phosphatases
US20040023382A1 (en) * 2002-07-31 2004-02-05 Isis Pharmaceuticals Inc. Antisense modulation of PPP3CB expression
US6828149B2 (en) 2002-06-20 2004-12-07 Isis Pharmaceuticals, Inc. Antisense modulation of PPP3R1 expression
JP2005530503A (ja) * 2002-06-25 2005-10-13 セローノ ジェネティクス インスティテュート ソシエテ アノニム 精神障害の治療におけるｐｐ２ａホスファターゼモジュレータの使用
EP1556333A1 (en) 2002-10-02 2005-07-27 Aventis Pharma Deutschland GmbH Hydroxyphenylundecane derivates, a process for their production and their use
US7923041B2 (en) 2005-02-03 2011-04-12 Signum Biosciences, Inc. Compositions and methods for enhancing cognitive function
CA2601777A1 (en) 2005-02-03 2006-08-10 Signum Biosciences, Inc. Compositions and methods for enhancing cognitive function
DE102006033321A1 (de) * 2006-07-17 2008-01-24 Westfälische Wilhelms-Universität Münster Medizinische Verwendung von N-Phenylpropenoyl-Aminosäurederivaten und verwandten Verbindungen
KR100980328B1 (ko) * 2007-12-14 2010-09-06 한국생명공학연구원 단백질 포스파타제의 활성을 억제하는트리아졸릴-티오-에타논 유도체 또는 이의 약학적으로 허용가능한 염을 유효성분으로 함유하는 암 예방 및 치료용조성물
US9486441B2 (en) 2008-04-21 2016-11-08 Signum Biosciences, Inc. Compounds, compositions and methods for making the same
PE20251179A1 (es) 2022-04-22 2025-04-23 Vertex Pharma Compuestos de heteroarilo para el tratamiento del dolor
CN119454697B (zh) * 2025-01-07 2025-04-08 首都医科大学附属北京地坛医院 一种小分子化合物在制备抗肝损伤或抗肝纤维化药物中的应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552558A (en) * 1989-05-23 1996-09-03 Abbott Laboratories Retroviral protease inhibiting compounds
US5280034A (en) * 1991-08-23 1994-01-18 E. R. Squibb & Sons, Inc. Bis-heterocyclic prostaglandin analogs
US5639725A (en) * 1994-04-26 1997-06-17 Children's Hospital Medical Center Corp. Angiostatin protein
US5770620A (en) * 1995-06-19 1998-06-23 Ontogen Corporation Aryl acrylic acid derivatives useful as protein tyrosine phosphatase inhibitors

Also Published As

Publication number Publication date
US5925660A (en) 1999-07-20
AU3820597A (en) 1998-02-20
EP0959884A4 (en:Method) 1999-12-15
JP2000515165A (ja) 2000-11-14
WO1998004257A1 (en) 1998-02-05
IL128217A0 (en) 1999-11-30
US5700821A (en) 1997-12-23
AR008120A1 (es) 1999-12-09
AU715546B2 (en) 2000-02-03
CA2261793A1 (en) 1998-02-05
EP0959884A1 (en) 1999-12-01
US5856506A (en) 1999-01-05
US6040323A (en) 2000-03-21

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Legal Events

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LAPS Cancellation because of no payment of annual fees